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Wirkstofftransport über biologische Barrieren

Prof Dr Claus-Michael Lehr

Die Forschung von Prof. Lehrs Arbeitsgruppe fokussiert sich auf neue Technologien zum sicheren und effizienten Transport von Anti-Infektiva über biologische Barrieren - wie Lunge, Intestinal-Trakt und Haut, aber auch Mucus, Biofilme und die bakterielle Zellwand.

Unsere Forschung

Durch große Fortschritte in der molekularen Biotechnologie und medizinischen Chemie werden immer mehr neue Wirkstoffkandidaten generiert. Bevor aus diesen erfolgreiche Therapeutika entstehen können, müssen jedoch die biopharmazeutischen Eigenschaften, im Besonderen in Bezug auf die Fähigkeit biologische Barrieren in Form von Gewebe, Zellen und zellulären Membranen zu überwinden, optimiert werden. Da eine weitere Optimierung der Wirkstoffe meist nicht möglich ist, werden neue Technologien benötigt, um einen sicheren und effektiven Wirkstofftransport an den Wirkungsort zu ermöglichen, bestenfalls durch eine nicht-invasive Applikation („nadel-frei“). In diesem Kontext arbeiten wir zum einen an innovativen Arzneistofftransportsystemen und auch an prädiktiven in vitro Modellen mit dem Ziel die präklinische Entwicklung zu beschleunigen und eine Translation zur klinischen Anwendung zu ermöglichen.

Team-Mitglieder

Forschungsprojekte

LUNG-ON-A-CHIP: Bioengineered microfluidic in vitro test system to study alveolar transport and clearance

Ziel dieses Projektes ist die Entwicklung und Integration eines innovativen Mikrofluidik Systems, welches die wesentlichen physiologischen Funktionen der Lunge sowie ihre einzigartige zelluläre Zusammensetzung nachahmt. Unsere organ-on-chip Systeme bilden, durch die Rekonstitution des humanen Alveolar Epithels in vitro, eine integrative Plattform die sowohl die Analyse des Stofftransports über die Luft-Blut-Schranke ermöglicht als auch die Untersuchung der Stoffaufnahme in und den anschließenden Abtransport durch alveolare Makrophagen erlaubt. Solche Modelle, in erkranktem sowie gesundem Zustand, werden voraussichtlich einen großen Einfluss auf die prädiktive präklinische Charakterisierung von neuartigen medizinischen Aerosolen haben.

 

ANTI-TB: Antibiotika-beladene Nanocarrier zur Therapeutischen Inhalation gegen Tuberkulose

Gegenstand und Ziel des ANTI-TB Projektes ist die Entwicklung einer neuartigen Therapieform für Tuberkulose, weil sie ist die weltweit wichtigste Bakterieninfektion des Menschen darstellt. Ihre Bekämpfung wird durch vermehrtes Auftreten therapieresistenter Erregerstämme behindert. Das Projekt nutzt einen nanomedizinischen Ansatz, um die unbefriedigende Therapiesituation besonders der Infektionen mit therapieresistenten Erregern zu verbessern und weitere Resistenzentwicklungen zu vermindern. Dazu sollen Nanocarrier mit spezifischen Oberflächenmodifikationen, die sie zielgerichtet zu Infektionsherden, zu infizierten Zellen und zu den Erregern lenken, mit neuen anti-TB Wirkstoffen kombiniert (Antibiotika-NC) und optimiert werden. Zur einfachen Anwendung sollen die wirksamsten Antibiotika-NC letztlich in eine Aerosol- bzw. Pulverinhalationstherapie überführt werden. Die Strategie zielt darauf ab, Wirkstoffkonzentrationen in der Lunge lokal zu erhöhen, um die Therapiedauer zu verkürzen, das Auftreten therapieresistenter Erreger zu minimieren, systemische Nebenwirkungen zu mindern und damit die Bereitschaft der Patienten zur Therapie zu verbessern. Das HIPS untersucht dabei die Auswirkungen und Interaktionen der Nanopartikel mit den physiologischen Flüssigkeiten Mucus und Lungensurfactant, sowie den Makrophagen und Epithelzellen. Aus den Nanopartikeln entwickeln wir eine lungengängige Pulverformulierung.

Projekthomepage: http://antitb.fz-borstel.de/index.php/de/

NEW DEAL: New nanotherapy research for inflammatory bowel diseases

Das NEW DEAL Projekt arbeitet daran eine hochselektive und lokale Therapie mit einem verbesserten Wirksamkeits- und Sicherheitsprofil für IBD-Patienten zu entwickeln. Dazu werden spezifische anti-Jak-1 bzw. Jak-3 siRNAs, Nanopartikelträger und eine Formulierung zur oralen Gabe entwickelt. Diese Behandlung könnte eine Alternative zu den bestehenden Therapien sein. In diesem Projekt bringt das HIPS sein Expertenwissen zu fortgeschrittenen Kokulturmodellen der entzündeten Darmbarriere und der Mucusbarriere ein. Wir untersuchen die Fähigkeit der Nanopartikel zur Überwindung der intestinalen Barrieren.

Projekthomepage: https://newdeal-project.eu/

 

Publikationen

2020

PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus

Anversa Dimer F, Souza Carvalho-Wodarz C, Goes A, Cirnski K, Herrmann J, Schmitt V, Pätzold L, Abed N, Rossi C, Bischoff M, …, Müller R, Lehr C (2020)

Nanomedicine : nanotechnology, biology, and medicine, 24DOI: 10.1016/j.nano.2019.102125

Advancing human in vitro pulmonary disease models in preclinical research: opportunities for lung-on-chips

Artzy-Schnirman A, Lehr C, Sznitman J (2020)

Expert Opinion on Drug Delivery, 17 (5): 621-625DOI: 10.1080/17425247.2020.1738380

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives

Montefusco-Pereira C, Horstmann J, Ebensen T, Beisswenger C, Bals R, Guzmán C, Schneider-Daum N, Carvalho-Wodarz C, Lehr C (2020)

Journal of visualized experiments : JoVE (160)DOI: 10.3791/61069

Safety assessment of excipients (SAFE) for orally inhaled drug products

Metz J, Scharnowske L, Hans F, Schnur S, Knoth K, Zimmer H, Limberger M, Groß H, Lehr C, Hittinger M (2020)

ALTEX, 37 (2): 275-286DOI: 10.14573/altex.1910231

Nanoparticle Targeting to Scalp Hair Follicles: New Perspectives for a Topical Therapy for Alopecia Areata

Christmann R, Thomas C, Jager N, Raber A, Loretz B, Schaefer U, Tschernig T, Vogt T, Lehr C (2020)

The Journal of investigative dermatology, 140 (1): 243-246DOI: 10.1016/j.jid.2019.05.028

pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers

Lee S, Kaya C, Jang H, Koch M, Loretz B, Buhler E, Lehr C, Hirsch A (2020)

Mater. Chem. Front., 4 (3): 905-909DOI: 10.1039/C9QM00651F

Itaconic Acid Increases the Efficacy of Tobramycin against Pseudomonas aeruginosa Biofilms

Ho D, Rossi C, Loretz B, Murgia X, Lehr C (2020)

Pharmaceutics, 12 (8)DOI: 10.3390/pharmaceutics12080691

Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections

Ho D, Murgia X, Rossi C, Christmann R, Hüfner de Mello Martins A, Koch M, Andreas A, Herrmann J, Müller R, Empting M, …, Couvreur P, Lehr C (2020)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202001407

Design and in vitro characterization of multistage silicon-PLGA budesonide particles for inflammatory bowel disease

Leonard F, Srinivasan S, Liu X, Collnot E, Ferrari M, Lehr C, Godin B (2020)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 151: 61-72DOI: 10.1016/j.ejpb.2020.03.020

3D air-liquid interface culture of Cystic Fibrosis bronchial epithelia, macrophages and P. aeruginosa to assess host-pathogen interaction and drug efficacy

Montefusco C, Montefusco-Pereira C (2020)

BookDOI: 10.22028/D291-31815

Inhalationstoxizität von Nanopartikeln // The role of alveolar macrophages in biokinetics and biological effects of inhaled nanoparticles

Koltermann-Jülly J (2020)

BookDOI: 10.22028/D291-31034

Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility

Montefusco-Pereira C, Formicola B, Goes A, Re F, Marrano C, Mantegazza F, Carvalho-Wodarz C, Fuhrmann G, Caneva E, Nicotra F, Lehr C, Russo L (2020)

European Journal of Pharmaceutics and Biopharmaceutics, 149: 12-20DOI: 10.1016/j.ejpb.2020.01.013

Streptococcal Extracellular Membrane Vesicles Are Rapidly Internalized by Immune Cells and Alter Their Cytokine Release

Mehanny M, Koch M, Lehr C, Fuhrmann G (2020)

Frontiers in immunology, 11DOI: 10.3389/fimmu.2020.00080

2019

Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier

Costa A, Souza Carvalho-Wodarz C, Seabra V, Sarmento B, Lehr C (2019)

Acta BiomaterialiaDOI: 10.1016/j.actbio.2019.04.037

Challenges and Strategies in Drug Delivery Systems for Treatment of Pulmonary Infections

Ho D, Nichols B, Edgar K, Murgia X, Loretz B, Lehr C (2019)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.VDOI: 10.1016/j.ejpb.2019.09.002

Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline

Artzy-Schnirman A, Hobi N, Schneider-Daum N, Guenat O, Lehr C, Sznitman J (2019)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 144: 11-17DOI: 10.1016/j.ejpb.2019.09.006

Preparation, characterization and in vitro antibacterial property of Ciprofloxacin-loaded nanostructured lipid carrier for treatment of Bacillus subtilis infection

Nnamani P, Ugwu A, Ibezim E, Onoja S, Odo A, Windbergs M, Rossi C, Lehr C, Attama A (2019)

Journal of Microencapsulation: 1-30DOI: 10.1080/02652048.2019.1582724

Capturing the Onset of Bacterial Pulmonary Infection in Acini‐On‐Chips

Artzy-Schnirman A, Zidan H, Elias-Kirma S, Ben-Porat L, Tenenbaum-Katan J, Carius P, Fishler R, Schneider-Daum N, Lehr C, Sznitman J (2019)

Adv. Biosys., 3 (9)DOI: 10.1002/adbi.201900026

The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

Formicola B, Dal Magro R, Montefusco-Pereira C, Lehr C, Koch M, Russo L, Grasso G, Deriu M, Danani A, Bourdoulous S, Re F (2019)

Journal of nanobiotechnology, 17 (1)DOI: 10.1186/s12951-019-0546-3

Macro- and Microrheological Properties of Mucus Surrogates in Comparison to Native Intestinal and Pulmonary Mucus

Huck B, Hartwig O, Biehl A, Schwarzkopf K, Wagner C, Loretz B, Murgia X, Lehr C (2019)

Biomacromolecules, 20 (9): 3504-3512DOI: 10.1021/acs.biomac.9b00780

Bioinspired Liposomes for Oral Delivery of Colistin to Combat Intracellular Infections by Salmonella enterica

Menina S, Eisenbeis J, Kamal M, Koch M, Bischoff M, Gordon S, Loretz B, Lehr C (2019)

Advanced healthcare materials, 8 (17)DOI: 10.1002/adhm.201900564

Preferential uptake of chitosan-coated PLGA nanoparticles by primary human antigen presenting cells

Durán V, Yasar H, Becker J, Thiyagarajan D, Loretz B, Kalinke U, Lehr C (2019)

Nanomedicine : nanotechnology, biology, and medicine, 21DOI: 10.1016/j.nano.2019.102073

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

Thanki K, van Eetvelde D, Geyer A, Fraire J, Hendrix R, van Eygen H, Putteman E, Sami H, Souza Carvalho-Wodarz C, Franzyk H, …, Ogris M, Foged C (2019)

Journal of controlled release : official journal of the Controlled Release Society, 310: 82-93DOI: 10.1016/j.jconrel.2019.08.004

OCTN2-Mediated Acetyl-l-Carnitine Transport in Human Pulmonary Epithelial Cells In Vitro

Salomon J, Gausterer J, Selo M, Hosoya K, Huwer H, Schneider-Daum N, Lehr C, Ehrhardt C (2019)

Pharmaceutics, 11 (8)DOI: 10.3390/pharmaceutics11080396

Interaction of nanoparticles with the pulmonary barrier; The role of mucus in health and disease // The Role of Airway Mucus as a Barrier to Nanoparticles: Implications for Pulmonary Drug Delivery

Murgia X, Murgia Esteve X (2019)

BookDOI: 10.22028/D291-31240

Pseudobacterial nanocarriers for intracellular delivery of anti-infectives

Castoldi A (2019)

UnpublishedWorkDOI: 10.22028/D291-27989

Non-invasive vaccination by nanoparticle-based messenger RNA (mRNA) delivery via the transfollicular route

Yasar H (2019)

UnpublishedWorkDOI: 10.22028/D291-27933

2018

Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles

Yasar H, Biehl A, Rossi C, Koch M, Murgia X, Loretz B, Lehr C (2018)

Journal of nanobiotechnology, 16 (1)DOI: 10.1186/s12951-018-0401-y

Oral delivery of macromolecular drugs

Savla R, Hartwig O, Lim Chin W, Loretz B, Lehr C (2018)

Pharm. Technol. Eur., 30 (7): 22-26

The role of mucus on drug transport and its potential to affect therapeutic outcomes

Murgia X, Loretz B, Hartwig O, Hittinger M, Lehr C (2018)

Advanced Drug Delivery Reviews, 124: 82-97DOI: 10.1016/j.addr.2017.10.009

Can lifecycle management safeguard innovation in the pharmaceutical industry?

Hering S, Loretz B, Friedli T, Lehr C, Stieneker F (2018)

Drug Discovery TodayDOI: 10.1016/j.drudis.2018.10.008

Farnesylated Glycol Chitosan as a Platform for Drug Delivery

Ho D, Frisch S, Biehl A, Terriac E, Rossi C, Schwarzkopf K, Lautenschläger F, Loretz B, Murgia X, Lehr C (2018)

Biomacromolecules, 19 (8): 3489-3501DOI: 10.1021/acs.biomac.8b00795

Chemically modified h CFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis

Haque, A. K. M. Ashiqul, Dewerth A, Antony J, Riethmüller J, Schweizer G, Weinmann P, Latifi N, Yasar H, Pedemonte N, …, Handgretinger R, Kormann M (2018)

Scientific Reports, 8 (1)DOI: 10.1038/s41598-018-34960-0

Postmenopausaler Lichen planopilaris alias fibrosierende frontotemporale Alopezie Kossard

Vogt T, Thomas C, Reichrath J, Schilling L, Mawlood D, Christmann R, Loretz B, Schäfer U, Lehr C, Müller C (2018)

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 69 (2): 134-142DOI: 10.1007/s00105-017-4118-x

Murine alveolar epithelial cells and their lentivirus-mediated immortalisation

Sapich S, Hittinger M, Hendrix-Jastrzebski R, Repnik U, Griffiths G, May T, Wirth D, Bals R, Schneider-Daum N, Lehr C (2018)

Alternatives to laboratory animals : ATLA, 46 (2): 73-89

Medium throughput breathing human primary cell alveolus-on-chip model

Stucki J, Hobi N, Galimov A, Stucki A, Schneider-Daum N, Lehr C, Huwer H, Frick M, Funke-Chambour M, Geiser T, Guenat O (2018)

Scientific Reports, 8 (1)DOI: 10.1038/s41598-018-32523-x

Towards Standardized Dissolution Techniques for In Vitro Performance Testing of Dry Powder Inhalers

Floroiu A, Klein M, Krämer J, Lehr C (2018)

Dissolution Technologies, 25 (3): 6-18DOI: 10.14227/DT250318P6

Starch-Chitosan Polyplexes

Yasar H, Ho D, Rossi C, Herrmann J, Gordon S, Loretz B, Lehr C (2018)

Polymers, 10 (3)DOI: 10.3390/polym10030252

Co-culture of human alveolar epithelial (hAELVi) and macrophage (THP-1) cell lines

Kletting S, Barthold S, Repnik U, Griffiths G, Loretz B, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2018)

ALTEX, 35 (2): 211-222DOI: 10.14573/altex.1607191

A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes

Serr I, Scherm M, Zahm A, Schug J, Flynn V, Hippich M, Kälin S, Becker M, Achenbach P, Nikolaev A, …, Ziegler A, Daniel C (2018)

Science translational medicine, 10 (422)DOI: 10.1126/scitranslmed.aag1782

Human airway mucus alters susceptibility of Pseudomonas aeruginosa biofilms to tobramycin, but not colistin

Müller L, Murgia X, Siebenbürger L, Börger C, Schwarzkopf K, Sewald K, Häussler S, Braun A, Lehr C, Hittinger M, Wronski S (2018)

The Journal of antimicrobial chemotherapy, 73 (10): 2762-2769DOI: 10.1093/jac/dky241

Combining MucilAir™ and Vitrocell® Powder Chamber for the In Vitro Evaluation of Nasal Ointments in the Context of Aerosolized Pollen

Metz J, Knoth K, Groß H, Lehr C, Stäbler C, Bock U, Hittinger M (2018)

Pharmaceutics, 10 (2)DOI: 10.3390/pharmaceutics10020056

Polysaccharide Submicrocarrier for Improved Pulmonary Delivery of Poorly Soluble Anti-infective Ciprofloxacin

Ho D, Costa A, Rossi C, Souza Carvalho-Wodarz C, Loretz B, Lehr C (2018)

Molecular pharmaceutics, 15 (3): 1081-1096DOI: 10.1021/acs.molpharmaceut.7b00967

In Vitro Model of the Gram-Negative Bacterial Cell Envelope for Investigation of Anti-Infective Permeation Kinetics

Graef F, Richter R, Fetz V, Murgia X, Rossi C, Schneider-Daum N, Allegretta G, Elgaher W, Haupenthal J, Empting M, …, Gordon S, Lehr C (2018)

ACS infectious diseases, 4 (8): 1188-1196DOI: 10.1021/acsinfecdis.7b00165

Vibrational spectroscopic imaging and live cell video microscopy for studying differentiation of primary human alveolar epithelial cells

Vukosavljevic B, Hittinger M, Hachmeister H, Pilger C, Murgia X, Gepp M, Gentile L, Huwer H, Schneider-Daum N, Huser T, Lehr C, Windbergs M (2018)

Journal of biophotonicsDOI: 10.1002/jbio.201800052

A novel co-culture model of human bronchial epithelial cells and Pseudomonas aeruginosa biofilms to mimic chronic lung infections in cystic fibrosis

Juntke J (2018)

UnpublishedWorkDOI: 10.22028/D291-27897

Novel anti-infective delivery systems for the treatment of pulmonary bacterial infections

Ho D (2018)

UnpublishedWorkDOI: 10.22028/D291-27854

Aspherical and Spherical InvA497-Functionalized Nanocarriers for Intracellular Delivery of Anti-Infective Agents

Castoldi A, Empting M, Rossi C, Mayr K, Dersch P, Hartmann R, Müller R, Gordon S, Lehr C (2018)

Pharm Res, 36 (1)DOI: 10.1007/s11095-018-2521-3

Extracellular vesicles protect glucuronidase model enzymes during freeze-drying

Frank J, Richter M, Rossi C, Lehr C, Fuhrmann K, Fuhrmann G (2018)

Scientific Reports, 8 (1)DOI: 10.1038/s41598-018-30786-y

2017

Permanent gene correction by means of nucleotide-modified messenger RNA

Kormann M, Lehr C, Loretz B, Malaeksefat E (2017)

Patent (DE/08.10.13/ DEA102013111099)

Cell and tissue-based in vitro models for improving the development of oral inhalation drug products

Hittinger M, Schneider-Daum N, Lehr C (2017)

European Journal of Pharmaceutics and Biopharmaceutics, 118: 73-78DOI: 10.1016/j.ejpb.2017.02.019

Nanoencapsulation of a glucocorticoid improves barrier function and anti-inflammatory effect on monolayers of pulmonary epithelial cell lines

Rigo L, Carvalho-Wodarz C, Pohlmann A, Guterres S, Schneider-Daum N, Lehr C, Beck R (2017)

European Journal of Pharmaceutics and BiopharmaceuticsDOI: 10.1016/j.ejpb.2017.05.006

Modelling the bronchial barrier in pulmonary drug delivery

Murgia X, Yasar H, Carvalho-Wodarz C, Loretz B, Gordon S, Schwarzkopf K, Schaefer U, Lehr C (2017)

European Journal of Pharmaceutics and Biopharmaceutics, 118: 79-88DOI: 10.1016/j.ejpb.2017.03.020

Lung alveoli array-on-chip with a bioartificial membrane

Zamprogno P, Achenbach S, Stucki J, Hobi N, Schneider-Daum N, Lehr C, Huwer H, Schmid R, Guenat O (2017)

Toxicology letters, 280DOI: 10.1016/j.toxlet.2017.07.974

A foam model highlights the differences of the macro- and microrheology of respiratory horse mucus

Gross A, Torge A, Schaefer U, Schneider M, Lehr C, Wagner C (2017)

Journal of the Mechanical Behavior of Biomedical Materials, 71: 216-222DOI: 10.1016/j.jmbbm.2017.03.009

Ciprofloxacin-loaded PLGA nanoparticles against cystic fibrosis P. aeruginosa lung infections

Günday Türeli N, Torge A, Juntke J, Schwarz B, Schneider-Daum N, Türeli A, Lehr C, Schneider M (2017)

European Journal of Pharmaceutics and Biopharmaceutics, 117: 363-371DOI: 10.1016/j.ejpb.2017.04.032

A Model for the Transient Subdiffusive Behavior of Particles in Mucus

Ernst M, John T, Guenther M, Wagner C, Schaefer U, Lehr C (2017)

Biophysical journal, 112 (1): 172-179DOI: 10.1016/j.bpj.2016.11.900

Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections

Castoldi A, Herr C, Niederstraßer J, Labouta H, Melero A, Gordon S, Schneider-Daum N, Bals R, Lehr C (2017)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 118: 62-67DOI: 10.1016/j.ejpb.2016.11.026

Biodegradable starch derivatives with tunable charge density-synthesis, characterization, and transfection efficiency

Thiele C, Loretz B, Lehr C (2017)

Drug delivery and translational research, 7 (2): 252-258DOI: 10.1007/s13346-016-0333-8

Tracing molecular and structural changes upon mucolysis with N-acetyl cysteine in human airway mucus

Vukosavljevic B, Murgia X, Schwarzkopf K, Schaefer U, Lehr C, Windbergs M (2017)

International journal of pharmaceutics, 533 (2): 373-376DOI: 10.1016/j.ijpharm.2017.07.022

Expression and Activity of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Distal Lung Epithelial Cells In Vitro

Nickel S, Selo M, Fallack J, Clerkin C, Huwer H, Schneider-Daum N, Lehr C, Ehrhardt C (2017)

Pharmaceutical researchDOI: 10.1007/s11095-017-2172-9

Targeted delivery of Cyclosporine A by polymeric nanocarriers improves the therapy of inflammatory bowel disease in a relevant mouse model

Melero A, Draheim C, Hansen S, Giner E, Carreras J, Talens-Visconti R, Garrigues T, Peris J, Recio M, Giner R, Lehr C (2017)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 119: 361-371DOI: 10.1016/j.ejpb.2017.07.004

Diverse Applications of Nanomedicine

Pelaz B, Alexiou C, Alvarez-Puebla R, Alves F, Andrews A, Ashraf S, Balogh L, Ballerini L, Bestetti A, Brendel C, …, Zhou X, Parak W (2017)

ACS Nano, 11 (3): 2313-2381DOI: 10.1021/acsnano.6b06040

Modeling the Gram-negative bacterial cell envelope

Gräf F (2017)

Book

Modeling and simulation of the interaction between particles and pulmonary mucus

Ernst M (2017)

Book

Interleukin-10-Loaded Nano- and Microparticles for the Local Treatment of the Intestinal Mucosa and the Deep Lung

Nico Alexander Mell (2017)

Autologous coculture of primary human alveolar epithelial cells and macrophages for evaluating the safety and efficacy of novel inhalation pharmaceuticals

Hittinger M (2017)

Book

Sustained drug delivery for local treatment of joint diseases

Sterner B (2017)

Book

2016

Anti-infectives in Drug Delivery-Overcoming the Gram-Negative Bacterial Cell Envelope

Graef F, Gordon S, Lehr C (2016)

Current topics in microbiology and immunology, 398: 475-496DOI: 10.1007/82_2016_491

New Horizons in the Development of Novel Needle-Free Immunization Strategies to Increase Vaccination Efficacy

Schulze K, Ebensen T, Riese P, Prochnow B, Lehr C, Guzman C (2016)

Current topics in microbiology and immunologyDOI: 10.1007/82_2016_495

The bacterial cell envelope as delimiter of anti-infective bioavailability – An in vitro permeation model of the Gram-negative bacterial inner membrane

Graef F, Vukosavljevic B, Michel J, Wirth M, Ries O, De Rossi C, Windbergs M, Rosilio V, Ducho C, Gordon S, Lehr C (2016)

Journal of Controlled Release, 243: 214-224DOI: 10.1016/j.jconrel.2016.10.018

Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities

Mostaghaci B, Loretz B, Lehr C (2016)

Current Pharmaceutical Design, 22 (11): 1529-33

In vitro models for evaluating safety and efficacy of novel technologies for skin drug delivery

Planz V, Lehr C, Windbergs M (2016)

Journal of Controlled Release, 242: 89-104DOI: 10.1016/j.jconrel.2016.09.002

miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity

Serr I, Furst R, Ott V, Scherm M, Nikolaev A, Gokmen F, Kalin S, Zillmer S, Bunk M, Weigmann B, …, Ziegler A, Daniel C (2016)

Proceedings of the National Academy of Sciences of the United States of America, 113 (43): 6659-DOI: 10.1073/pnas.1606646113

IL-17A-mediated expression of epithelial IL-17C promotes inflammation during acute Pseudomonas aeruginosa pneumonia

Wolf L, Sapich S, Honecker A, Jungnickel C, Seiler F, Bischoff M, Wonnenberg B, Herr C, Schneider-Daum N, Lehr C, Bals R, Beisswenger C (2016)

American Journal of Physiology - Lung Cellular and Molecular Physiology, 311 (5): 1015-DOI: 10.1152/ajplung.00158.2016

A 3D co-culture of three human cell lines to model the inflamed intestinal mucosa for safety testing of nanomaterials

Susewind J, Souza Carvalho-Wodarz C, Repnik U, Collnot E, Schneider-Daum N, Griffiths G, Lehr C (2016)

Nanotoxicology, 10 (1): 53-62DOI: 10.3109/17435390.2015.1008065

Invasin-functionalized liposome nanocarriers improve the intracellular delivery of anti-infective drugs

Menina S, Labouta H, Geyer R, Krause T, Gordon S, Dersch P, Lehr C (2016)

RSC Advances, 6 (47): 41622-41629DOI: 10.1039/c6ra02988d

Autologous co-culture of primary human alveolar macrophages and epithelial cells for investigating aerosol medicines. Part II: evaluation of IL-10-loaded microparticles for the treatment of lung inflammation

Hittinger M, Mell N, Huwer H, Loretz B, Schneider-Daum N, Lehr C (2016)

Alternatives to laboratory animals : ATLA, 44 (4): 349-360

Size-Limited Penetration of Nanoparticles into Porcine Respiratory Mucus after Aerosol Deposition

Murgia X, Pawelzyk P, Schaefer U, Wagner C, Willenbacher N, Lehr C (2016)

Biomacromolecules, 17 (4): 1536-1542DOI: 10.1021/acs.biomac.6b00164

Dual flow bioreactor with ultrathin microporous TEER sensing membrane for evaluation of nanoparticle toxicity

Sbrana T, Ucciferri N, Favrè M, Ahmed S, Collnot E, Lehr C, Ahluwalia A, Liley M (2016)

Sensors and Actuators, B: Chemical, 223: 440-446DOI: 10.1016/j.snb.2015.09.078

Impact of PEG and PEG-b-PAGE modified PLGA on nanoparticle formation, protein loading and release

Rietscher R, Czaplewska J, Majdanski T, Gottschaldt M, Schubert U, Schneider M, Lehr C (2016)

International journal of pharmaceutics, 500 (1-2): 187-195DOI: 10.1016/j.ijpharm.2016.01.021

Budesonide Loaded PLGA Nanoparticles for Targeting the Inflamed Intestinal Mucosa--Pharmaceutical Characterization and Fluorescence Imaging

Ali H, Weigmann B, Collnot E, Khan S, Windbergs M, Lehr C (2016)

Pharmaceutical research, 33 (5): 1085-92DOI: 10.1007/s11095-015-1852-6

Nanoparticle-Based Mucosal Vaccines Targeting Tumor-Associated Antigens to Human Dendritic Cells

Brito Baleeiro R, Schweinlin M, Rietscher R, Diedrich A, Czaplewska J, Metzger M, Michael Lehr C, Scherließ R, Hanefeld A, Gottschaldt M, Walden P (2016)

j biomed nanotechnol, 12 (7): 1527-1543DOI: 10.1166/jbn.2016.2267

Autologous co-culture of primary human alveolar macrophages and epithelial cells for investigating aerosol medicines. Part I: Model Characterisation

Hittinger M, Janke J, Huwer H, Scherließ R, Schneider-Daum N, Lehr C (2016)

ATLA Alternatives to Laboratory Animals, 44 (4): 337-347

Preparation of nanosized coacervates of positive and negative starch derivatives intended for pulmonary delivery of proteins

Barthold S, Kletting S, Taffner J, De Souza Carvalho-Wodarz C, Lepeltier E, Loretz B, Lehr C (2016)

Journal of Materials Chemistry B, 4 (13): 2377-2386DOI: 10.1039/c6tb00178e

Sustained-release liquisolid compact tablets containing artemether-lumefantrine as alternate-day regimen for malaria treatment to improve patient compliance

Nnamani P, Ugwu A, Ibezim E, Kenechukwu F, Akpa P, Ogbonna J, Obitte N, Odo A, Windbergs M, Lehr C, Attama A (2016)

International Journal of Nanomedicine, 11: 6365-6378DOI: 10.2147/IJN.S92755

Design of Polyamine-Grafted Starches for Nucleotide Analogue Delivery: In Vitro Evaluation of the Anticancer Activity

Kanber E, Yamada H, Loretz B, Lepeltier E, Lehr C (2016)

Bioconjugate chemistryDOI: 10.1021/acs.bioconjchem.6b00396

Different macro- and micro-rheological properties of native porcine respiratory and intestinal mucus

Bokkasam H, Ernst M, Guenther M, Wagner C, Schaefer U, Lehr C (2016)

International journal of pharmaceutics, 510 (1): 164-167DOI: 10.1016/j.ijpharm.2016.06.035

Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier

Kuehn A, Kletting S, Souza Carvalho-Wodarz C, Repnik U, Griffiths G, Fischer U, Meese E, Huwer H, Wirth D, May T, Schneider-Daum N, Lehr C (2016)

ALTEX, 33 (3): 251-60DOI: 10.14573/altex.1511131

Influence of agglomeration and specific lung lining lipid/protein interaction on short-term inhalation toxicity

Wohlleben W, Driessen M, Raesch S, Schaefer U, Schulze C, Vacano B, Vennemann A, Wiemann M, Ruge C, Platsch H, …, Lehr C, Haase A (2016)

Nanotoxicology, 10 (7): 970-980DOI: 10.3109/17435390.2016.1155671

Self-Assembly and Shape Control of Hybrid Nanocarriers Based on Calcium Carbonate and Carbon Nanodots

Lauth V, Loretz B, Lehr C, Maas M, Rezwan K (2016)

Chemistry of Materials, 28 (11): 3796-3803DOI: 10.1021/acs.chemmater.6b00769

Nanocarriers for optimizing the balance between interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverse effects

Mathes C, Melero A, Conrad P, Vogt T, Rigo L, Selzer D, Prado W, De Rossi C, Garrigues T, Hansen S, …, Lehr C, Schaefer U (2016)

Journal of Controlled Release, 223: 207-214DOI: 10.1016/j.jconrel.2015.12.010

Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity

Rietscher R, Schröder M, Janke J, Czaplewska J, Gottschaldt M, Scherließ R, Hanefeld A, Schubert U, Schneider M, Knolle P, Lehr C (2016)

European Journal of Pharmaceutics and Biopharmaceutics, 102: 20-31DOI: 10.1016/j.ejpb.2016.02.014

Tight junctions form a barrier in porcine hair follicles

Mathes C, Brandner J, Laue M, Raesch S, Hansen S, Failla A, Vidal S, Moll I, Schaefer U, Lehr C (2016)

European Journal of Cell Biology, 95 (2): 89-99DOI: 10.1016/j.ejcb.2015.12.001

The effect of polymer size and charge of molecules on permeation through synovial membrane and accumulation in hyaline articular cartilage

Sterner B, Harms M, Wöll S, Weigandt M, Windbergs M, Lehr C (2016)

European Journal of Pharmaceutics and Biopharmaceutics, 101: 126-136DOI: 10.1016/j.ejpb.2016.02.004

Label-free analysis of drug delivery systems and cellular interaction studies using confocal Raman microscopy

Kann B (2016)

Book

Tunable nanoparticles for the local delivery of protein drugs for improved vaccination

Rietscher R (2016)

Book

Immortalization of human alveolar epithelial cells

Kühn A (2016)

Book

Mathematical characterization of skin absorption

Selzer D (2016)

Book

Drug delivery to the hair follicle

Mathes C (2016)

Book

A new cell line-based coculture model of the human air-blood barrier to evaluate the interaction with aerosolized drug carriers

Kletting S (2016)

Book

The nanoparticle corona in the deep lung

Räsch S (2016)

Book

Confocal Raman microscopy in skin drug delivery research

Franzen L (2016)

Book

2015

Overview of Inhaled Nanopharmaceuticals

Barthold S, Kunschke N, Murgia X, Loretz B, Carvalho Wodarz C, Lehr C (2015)

Book

Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models

Hittinger M, Juntke J, Kletting S, Schneider-Daum N, de Souza Carvalho C, Lehr C (2015)

Advanced Drug Delivery Reviews, 85: 44-56DOI: 10.1016/j.addr.2014.10.011

Not just for tumor targeting: Unmet medical needs and opportunities for nanomedicine

Lepeltier E, Nuhn L, Lehr C, Zentel R (2015)

Nanomedicine, 10 (20): 3147-3166DOI: 10.2217/nnm.15.132

Efficient nanoparticle-mediated needle-free transcutaneous vaccination via hair follicles requires adjuvantation

Mittal A, Schulze K, Ebensen T, Weißmann S, Hansen S, Lehr C, Guzmán C (2015)

Nanomedicine: Nanotechnology, Biology, and Medicine, 11 (1): 147-154DOI: 10.1016/j.nano.2014.08.009

Semi-automated nanoprecipitation-system - An option for operator independent, scalable and size adjustable nanoparticle synthesis

Rietscher R, Thum C, Lehr C, Schneider M (2015)

Pharmaceutical research, 32 (6): 1859-1863DOI: 10.1007/s11095-014-1612-z

In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency

Mahiny A, Dewerth A, Mays L, Alkhaled M, Mothes B, Malaeksefat E, Loretz B, Rottenberger J, Brosch D, Reautschnig P, …, Lehr C, Kormann M (2015)

Nature biotechnology, 33 (6): 584-6DOI: 10.1038/nbt.3241

The buccal mucosa as a route for TiO2 nanoparticle uptake

Teubl B, Leitinger G, Schneider M, Lehr C, Fröhlich E, Zimmer A, Roblegg E (2015)

Nanotoxicology, 9 (2): 253-261DOI: 10.3109/17435390.2014.921343

Inverse micellar sugar glass (IMSG) nanoparticles for transfollicular vaccination

Mittal A, Schulze K, Ebensen T, Weissmann S, Hansen S, Guzmán C, Lehr C (2015)

Journal of Controlled Release, 206: 140-152DOI: 10.1016/j.jconrel.2015.03.017

Squalenoylation of Chitosan: A Platform for Drug Delivery?

Lepeltier E, Loretz B, Desmaele D, Zapp J, Herrmann J, Couvreur P, Lehr C (2015)

Biomacromolecules, 16 (9): 2930-9DOI: 10.1021/acs.biomac.5b00840

Miniature in vitro dissolution testing of powders for inhalation

May S, Kind S, Jensen B, Wolkenhauer M, Schneider M, Lehr C (2015)

Dissolution Technologies, 22 (3): 40-51DOI: 10.14227/DT220315P40

Solid Phase Extraction as an Innovative Separation Method for Measuring Free and Entrapped Drug in Lipid Nanoparticles

Guillot A, Couffin A, Sejean X, Navarro F, Limberger M, Lehr C (2015)

Pharmaceutical research, 32 (12): 3999-4009DOI: 10.1007/s11095-015-1761-8

Focused Ultrasound as a Scalable and Contact-Free Method to Manufacture Protein-Loaded PLGA Nanoparticles

Schiller S, Hanefeld A, Schneider M, Lehr C (2015)

Pharmaceutical research, 32 (9): 2995-3006DOI: 10.1007/s11095-015-1681-7

Dimethylaminoethyl methacrylate copolymer-siRNA nanoparticles for silencing a therapeutically relevant gene in macrophages

Jain R, Dandekar P, Loretz B, Koch M, Lehr C (2015)

MedChemComm, 6 (4): 691-701DOI: 10.1039/c4md00490f

A strategy for in-silico prediction of skin absorption in man

Selzer D, Neumann D, Neumann H, Kostka K, Lehr C, Schaefer U (2015)

European Journal of Pharmaceutics and Biopharmaceutics, 95: 68-76DOI: 10.1016/j.ejpb.2015.05.002

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology

Gordon S, Daneshian M, Bouwstra J, Caloni F, Constant S, Davies D, Dandekar G, Guzman C, Fabian E, Haltner E, …, Walles H, Lehr C (2015)

ALTEX, 32 (4): 327-378DOI: 10.14573/altex.1510051

Cyclodextrin-based star polymers as a versatile platform for nanochemotherapeutics: Enhanced entrapment and uptake of idarubicin

Nafee N, Hirosue M, Loretz B, Wenz G, Lehr C (2015)

Colloids and surfaces. B, Biointerfaces, 129: 30-8DOI: 10.1016/j.colsurfb.2015.03.014

Spatial separation of the processing and MHC class I loading compartments for cross-presentation of the tumor-associated antigen HER2/neu by human dendritic cells

Baleeiro R, Rietscher R, Diedrich A, Czaplewska J, Lehr C, Scherließ R, Hanefeld A, Gottschaldt M, Walden P (2015)

Oncoimmunology, 4 (11)DOI: 10.1080/2162402X.2015.1047585

Inhalable Clarithromycin Microparticles for Treatment of Respiratory Infections

Dimer F, De Souza Carvalho-Wodarz C, Haupenthal J, Hartmann R, Lehr C (2015)

Pharmaceutical research, 32 (12): 3850-3861DOI: 10.1007/s11095-015-1745-8

Proteomic and Lipidomic Analysis of Nanoparticle Corona upon Contact with Lung Surfactant Reveals Differences in Protein, but Not Lipid Composition

Raesch S, Tenzer S, Storck W, Rurainski A, Selzer D, Ruge C, Perez-Gil J, Schaefer U, Lehr C (2015)

ACS Nano, 9 (12): 11872-11885DOI: 10.1021/acsnano.5b04215

Mono- and Cocultures of Bronchial and Alveolar Epithelial Cells Respond Differently to Proinflammatory Stimuli and Their Modulation by Salbutamol and Budesonide

Haghi M, Hittinger M, Zeng Q, Oliver B, Traini D, Young P, Huwer H, Schneider-Daum N, Lehr C (2015)

Molecular pharmaceutics, 12 (8): 2625-32DOI: 10.1021/acs.molpharmaceut.5b00124

Bacteriomimetic invasin-functionalized nanocarriers for intracellular delivery

Labouta H, Menina S, Kochut A, Gordon S, Geyer R, Dersch P, Lehr C (2015)

Journal of Controlled Release, 220: 414-424DOI: 10.1016/j.jconrel.2015.10.052

Macrophage uptake of cylindrical microparticles investigated with correlative microscopy

Tscheka C, Hittinger M, Lehr C, Schneider-Daum N, Schneider M (2015)

European Journal of Pharmaceutics and Biopharmaceutics, 95: 151-155DOI: 10.1016/j.ejpb.2015.03.010

Transfection system of amino-functionalized calcium phosphate nanoparticles: in vitro efficacy, biodegradability, and immunogenicity study

Mostaghaci B, Susewind J, Kickelbick G, Lehr C, Loretz B (2015)

ACS applied materials & interfaces, 7 (9): 5124-33DOI: 10.1021/am507193a

In vitro–in vivo correlation

Barakat A, Krämer J, Souza Carvalho C, Lehr C (2015)

Dissolution Technologies, 22 (2): 19-22DOI: 10.14227/DT220215P19

A design of experiment study of nanoprecipitation and nano spray drying as processes to prepare plga nano-and microparticles with defined sizes and size distributions

Draheim C, De Crécy F, Hansen S, Collnot E, Lehr C (2015)

Pharmaceutical research, 32 (8): 2609-2624DOI: 10.1007/s11095-015-1647-9

Enhanced uptake and siRNA-mediated knockdown of a biologically relevant gene using cyclodextrin polyrotaxane

Dandekar P, Jain R, Keil M, Loretz B, Koch M, Wenz G, Lehr C (2015)

Journal of Materials Chemistry B, 3 (13): 2590-2598DOI: 10.1039/c4tb01821d

Expression and function of the epithelial sodium channel δ-subunit in human respiratory epithelial cells in vitro

Schwagerus E, Sladek S, Buckley S, Armas-Capote N, La Rosa D, Harvey B, Fischer H, Illek B, Huwer H, Schneider-Daum N, Lehr C, Ehrhardt C (2015)

Pflugers Archiv European Journal of Physiology, 467 (11): 2257-2273DOI: 10.1007/s00424-015-1693-5

P-glycoprotein interactions of novel psychoactive substances - stimulation of ATP consumption and transport across Caco-2 monolayers

Meyer M, Wagmann L, Schneider-Daum N, Loretz B, Souza Carvalho C, Lehr C, Maurer H (2015)

Biochemical pharmacology, 94 (3): 220-6DOI: 10.1016/j.bcp.2015.01.008

Organic cation transporter function in different in vitro models of human lung epithelium

Salomon J, Gausterer J, Yahara T, Hosoya K, Huwer H, Hittinger M, Schneider-Daum N, Lehr C, Ehrhardt C (2015)

European Journal of Pharmaceutical Sciences, 80: 82-88DOI: 10.1016/j.ejps.2015.08.007

Development and characterization of nanoparticular systems for an innovating therapeutic concept for targeting Inflammatory Bowel Diseases using the Quality-by-Design approach

Guillot A (2015)

Synthesis and Characterization of Novel Amino-modified Calcium Phosphate Nanoparticles Used for Gene Delivery Applications

Mostaghaci B (2015)

Advanced formulations of cyclosporine A and budesonide for the therapy of inflammatory bowel disease

Draheim C (2015)

Book

2014

Transfollicular delivery takes root

Hansen S, Lehr C (2014)

Expert Review of Vaccines, 13 (1): 5-7DOI: 10.1586/14760584.2014.862500

Carrier interactions with the biological barriers of the lung: Advanced in vitro models and challenges for pulmonary drug delivery

de Souza Carvalho C, Daum N, Lehr C (2014)

Advanced Drug Delivery Reviews, 75: 129-140DOI: 10.1016/j.addr.2014.05.014

Overcoming the pulmonary barrier: New insights to improve the efficiency of inhaled therapeutics

Murgia X, de Souza Carvalho C, Lehr C (2014)

European Journal of Nanomedicine, 6 (3): 157-169DOI: 10.1515/ejnm-2014-0019

Quantification of nanoparticle uptake into hair follicles in pig ear and human forearm

Raber A, Mittal A, Schäfer J, Bakowsky U, Reichrath J, Vogt T, Schaefer U, Hansen S, Lehr C (2014)

Journal of Controlled Release, 179 (1): 25-32DOI: 10.1016/j.jconrel.2014.01.018

Dissolution testing of powders for inhalation

May S, Jensen B, Weiler C, Wolkenhauer M, Schneider M, Lehr C (2014)

Pharmaceutical research, 31 (11): 3211-3224DOI: 10.1007/s11095-014-1413-4

Characterization and evaluation of a modified PVPA barrier in comparison to Caco-2 cell monolayers for combined dissolution and permeation testing

Gantzsch S, Kann B, Ofer-Glaessgen M, Loos P, Berchtold H, Balbach S, Eichinger T, Lehr C, Schaefer U, Windbergs M (2014)

Journal of Controlled Release, 175 (1): 79-86DOI: 10.1016/j.jconrel.2013.12.009

In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response

Ucciferri N, Collnot E, Gaiser B, Tirella A, Stone V, Domenici C, Lehr C, Ahluwalia A (2014)

Nanotoxicology, 8 (6): 697-708DOI: 10.3109/17435390.2013.831500

The cell line NCl-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier

Salomon J, Muchitsch V, Gausterer J, Schwagerus E, Huwer H, Daum N, Lehr C, Ehrhardt C (2014)

Molecular pharmaceutics, 11 (3): 995-1006DOI: 10.1021/mp4006535

Antibiotic-free nanotherapeutics: Ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors

Nafee N, Husari A, Maurer C, Lu C, De Rossi C, Steinbach A, Hartmann R, Lehr C, Schneider M (2014)

Journal of Controlled Release, 192: 131-140DOI: 10.1016/j.jconrel.2014.06.055

Statistical comparison of dissolution profiles to predict the bioequivalence of extended release formulations

Gomez-Mantilla J, Schaefer U, Casabo V, Lehr T, Lehr C (2014)

AAPS Journal, 16 (4): 791-801DOI: 10.1208/s12248-014-9615-6

Budesonide loaded nanoparticles with pH-sensitive coating for improved mucosal targeting in mouse models of inflammatory bowel diseases

Ali H, Weigmann B, Neurath M, Collnot E, Windbergs M, Lehr C (2014)

Journal of Controlled Release, 183 (1): 167-177DOI: 10.1016/j.jconrel.2014.03.039

Non-invasive determination of cellular oxygen consumption as novel cytotoxicity assay for nanomaterials

Neumeyer A, Bukowski M, Veith M, Lehr C, Daum N (2014)

Nanotoxicology, 8 (1): 50-60DOI: 10.3109/17435390.2012.747639

Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application

Nnamani P, Hansen S, Windbergs M, Lehr C (2014)

International journal of pharmaceutics, 477 (1-2): 208-217DOI: 10.1016/j.ijpharm.2014.10.004

Polyester-idarubicin nanoparticles and a polymer-photosensitizer complex as potential drug formulations for cell-mediated drug delivery

Blaudszun A, Lian Q, Schnabel M, Loretz B, Steinfeld U, Lee H, Wenz G, Lehr C, Schneider M, Philippi A (2014)

International journal of pharmaceutics, 474 (1-2): 70-9DOI: 10.1016/j.ijpharm.2014.07.048

Crystal suspensions of poorly soluble peptides for intra-articular application: A novel approach for biorelevant assessment of their in vitro release

Sterner B, Harms M, Weigandt M, Windbergs M, Lehr C (2014)

International journal of pharmaceutics, 461 (1-2): 46-53DOI: 10.1016/j.ijpharm.2013.11.031

Design of starch-graft-PEI polymers: an effective and biodegradable gene delivery platform

Yamada H, Loretz B, Lehr C (2014)

Biomacromolecules, 15 (5): 1753-61DOI: 10.1021/bm500128k

Nanoencapsulation in lipid-core nanocapsules controls mometasone furoate skin permeability rate and its penetration to the deeper skin layers

Melero A, Ferreira Ourique A, Stanisçuaski Guterres S, Raffin Pohlmann A, Lehr C, Ruver Beck R, Schaefer U (2014)

Skin Pharmacology and Physiology, 27 (4): 217-228DOI: 10.1159/000354921

Endothelial and epithelial differentiation potential of human adult stem cells PSC and MSC and the relation of ZO-1 isoform ratio to epithelial differentiation in Caco-2

Meier K (2014)

Book

Starch based cationic polymers for gene delivery

Yamada H (2014)

Book

Statistical approaches to perform dissolution profile comparisons

Gómez Mantilla J (2014)

Book

Exploring the follicular route for transcutaneous vaccination using nanoparticles

Mittal A (2014)

2013

Particle based vaccine formulations for transcutaneous immunization

Mittal A, Raber A, Lehr C, Hansen S (2013)

Human Vaccines and Immunotherapeutics, 9 (9): 1950-1955DOI: 10.4161/hv.25217

Improved input parameters for diffusion models of skin absorption

Hansen S, Lehr C, Schaefer U (2013)

Advanced Drug Delivery Reviews, 65 (2): 251-264DOI: 10.1016/j.addr.2012.04.011

Modeling the human skin barrier-Towards a better understanding of dermal absorption

Hansen S, Lehr C, Schaefer U (2013)

Advanced Drug Delivery Reviews, 65 (2): 149-151DOI: 10.1016/j.addr.2012.12.002

Pulmonary drug delivery: From generating aerosols to overcoming biological barriers-therapeutic possibilities and technological challenges

Ruge C, Kirch J, Lehr C (2013)

The Lancet Respiratory Medicine, 1 (5): 402-413DOI: 10.1016/S2213-2600(13)70072-9

Mucus as a barrier to lipophilic drugs

Sigurdsson H, Kirch J, Lehr C (2013)

International journal of pharmaceutics, 453 (1): 56-64DOI: 10.1016/j.ijpharm.2013.05.040

Crossing biological barriers for advanced drug delivery

Schneider M, Windbergs M, Daum N, Loretz B, Collnot E, Hansen S, Schaefer U, Lehr C (2013)

European Journal of Pharmaceutics and Biopharmaceutics, 84 (2): 239-241DOI: 10.1016/j.ejpb.2013.03.009

Nanomedicines for the treatment of inflammatory bowel diseases

Ali H, Collnot E, Windbergs M, Lehr C (2013)

European Journal of Nanomedicine, 5 (1)DOI: 10.1515/ejnm-2013-0004

From the structure of the skin barrier and dermal formulations to in vitro transport models for skin absorption

Windbergs M, Hansen S, Schroeter A, Schaefer U, Lehr C, Bouwstra J (2013)

Skin Pharmacology and Physiology, 26 (4-6): 317-330DOI: 10.1159/000351936

PEG-functionalized microparticles selectively target inflamed mucosa in inflammatory bowel disease

Lautenschläger C, Schmidt C, Lehr C, Fischer D, Stallmach A (2013)

European Journal of Pharmaceutics and Biopharmaceutics, 85 (3 PART A): 578-586DOI: 10.1016/j.ejpb.2013.09.016

Biopharmaceutical in vitro characterization of CPZEN-45, a drug candidate for inhalation therapy of tuberculosis

Salomon J, Galeron P, Schulte N, Morow P, Severynse-Stevens D, Huwer H, Daum N, Lehr C, Hickey A, Ehrhardt C (2013)

Therapeutic delivery, 4 (8): 915-923DOI: 10.4155/tde.13.62

In situ drug release monitoring with a fiber-optic system: Overcoming matrix interferences using derivative spectrophotometry

Guillot A, Limberge M, Krämer J, Lehr C (2013)

Dissolution Technologies, 20 (2): 15-19

One-step synthesis of nanosized and stable amino-functionalized calcium phosphate particles for DNA transfection

Mostaghaci B, Loretz B, Haberkorn R, Kickelbick G, Lehr C (2013)

Chemistry of Materials, 25 (18): 3667-3674DOI: 10.1021/cm401886u

Nanoparticle geometry and surface orientation influence mode of cellular uptake

Herd H, Daum N, Jones A, Huwer H, Ghandehari H, Lehr C (2013)

ACS Nano, 7 (3): 1961-1973DOI: 10.1021/nn304439f

Non-invasive delivery of nanoparticles to hair follicles: A perspective for transcutaneous immunization

Mittal A, Raber A, Schaefer U, Weissmann S, Ebensen T, Schulze K, Guzmán C, Lehr C, Hansen S (2013)

Vaccine, 31 (34): 3442-3451DOI: 10.1016/j.vaccine.2012.12.048

Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa - A first in vivo study in human patients

Schmidt C, Lautenschlaeger C, Collnot E, Schumann M, Bojarski C, Schulzke J, Lehr C, Stallmach A (2013)

Journal of Controlled Release, 165 (2): 139-145DOI: 10.1016/j.jconrel.2012.10.019

Finite dose skin mass balance including the lateral part: Comparison between experiment, pharmacokinetic modeling and diffusion models

Selzer D, Hahn T, Naegel A, Heisig M, Kostka K, Lehr C, Neumann D, Schaefer U, Wittum G (2013)

Journal of Controlled Release, 165 (2): 119-128DOI: 10.1016/j.jconrel.2012.10.009

Pulmonary surfactant is indispensable in order to simulate the in vivo situation

Schleh C, Kreyling W, Lehr C (2013)

Particle and Fibre Toxicology, 10 (1)DOI: 10.1186/1743-8977-10-6

Permutation Test (PT) and Tolerated Difference Test (TDT)

Gómez-Mantilla J, Casabó V, Schaefer U, Lehr C (2013)

International journal of pharmaceutics, 441 (1-2): 458-467DOI: 10.1016/j.ijpharm.2012.11.008

Budesonide Loaded pH-sensitive PLGA Nanoparticles for the Treatment of Inflammatory Bowel Disease

Ali H (2013)

Novel cell based in vitro models to study nanoparticle interaction with the inflamed intestinal mucosa

Leonard F (2013)

Book

Dissolution testing of powders for inhalation

May S (2013)

Book

Implementation of a lipid-coated membrane in a combined dissolution and permeation system and comparison to Caco-2 cell monolayers

Gantzsch S (2013)

Book

2012

Isolation, cultivation, and application of human alveolar epithelial cells

Daum N, Kuehn A, Hein S, Schaefer U, Huwer H, Lehr C (2012)

Methods in molecular biology (Clifton, N.J.), 806: 31-42DOI: 10.1007/978-1-61779-367-7_3

Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus

Kirch J, Schneider A, Abou B, Hopf A, Schaefer U, Schneider M, Schall C, Wagner C, Lehr C (2012)

Proceedings of the National Academy of Sciences of the United States of America, 109 (45): 18355-18360DOI: 10.1073/pnas.1214066109

Nanoparticles for transcutaneous vaccination

Hansen S, Lehr C (2012)

Microbial Biotechnology, 5 (2): 156-167DOI: 10.1111/j.1751-7915.2011.00284.x

Nano- and microparticulate drug carriers for targeting of the inflamed intestinal mucosa

Collnot E, Ali H, Lehr C (2012)

Journal of Controlled Release, 161 (2): 235-246DOI: 10.1016/j.jconrel.2012.01.028

Characterization and evaluation of β-glucan formulations as injectable implants for protein and peptide delivery

Jacobs S, Bunt C, Wu Z, Lehr C, Rupenthal I (2012)

Drug Development and Industrial Pharmacy, 38 (11): 1337-1343DOI: 10.3109/03639045.2011.650646

Process optimization and biocompatibility of cell carriers suitable for automated magnetic manipulation

Krejci I, Piana C, Howitz S, Wegener T, Fiedler S, Zwanzig M, Schmitt D, Daum N, Meier K, Lehr C, …, Wirth M, Gabor F (2012)

Acta Biomaterialia, 8 (3): 1239-1247DOI: 10.1016/j.actbio.2011.08.031

A hydrophobic starch polymer for nanoparticle-mediated delivery of docetaxel

Dandekar P, Jain R, Stauner T, Loretz B, Koch M, Wenz G, Lehr C (2012)

Macromolecular Bioscience, 12 (2): 184-94DOI: 10.1002/mabi.201100244

Cellular delivery of polynucleotides by cationic cyclodextrin polyrotaxanes

Dandekar P, Jain R, Keil M, Loretz B, Muijs L, Schneider M, Auerbach D, Jung G, Lehr C, Wenz G (2012)

Journal of controlled release : official journal of the Controlled Release Society, 164 (3): 387-93DOI: 10.1016/j.jconrel.2012.06.040

Treatment of lung cancer via telomerase inhibition

Nafee N, Schneider M, Friebel K, Dong M, Schaefer U, Mürdter T, Lehr C (2012)

European Journal of Pharmaceutics and Biopharmaceutics, 80 (3): 478-489DOI: 10.1016/j.ejpb.2011.11.019

Atomic force microscopy and analytical ultracentrifugation for probing nanomaterial protein interactions

Schaefer J, Schulze C, Marxer E, Schaefer U, Wohlleben W, Bakowsky U, Lehr C (2012)

ACS Nano, 6 (6): 4603-4614DOI: 10.1021/nn202657q

Influence of the application area on finite dose permeation in relation to drug type applied

Hahn T, Selzer D, Neumann D, Kostka K, Lehr C, Schaefer U (2012)

Experimental Dermatology, 21 (3): 233-235DOI: 10.1111/j.1600-0625.2011.01424.x

Mucociliary clearance of micro- and nanoparticles is independent of size, shape and charge-an ex vivo and in silico approach

Kirch J, Guenther M, Doshi N, Schaefer U, Schneider M, Mitragotri S, Lehr C (2012)

Journal of Controlled Release, 159 (1): 128-134DOI: 10.1016/j.jconrel.2011.12.015

Pulmonary delivery and tissue distribution of aerosolized antisense 2'-O-Methyl RNA containing nanoplexes in the isolated perfused and ventilated rat lung

Dong M, Murdter T, Philippi C, Loretz B, Schaefer U, Lehr C, Schwab M, Ammon-Treiber S (2012)

European Journal of Pharmaceutics and Biopharmaceutics, 81 (3): 478-85DOI: 10.1016/j.ejpb.2012.04.022

Screening of budesonide nanoformulations for treatment of inflammatory bowel disease in an inflamed 3D cell-culture model

Leonard F, Ali H, Collnot E, Crielaard B, Lammers T, Storm G, Lehr C (2012)

ALTEX, 29 (3): 275-285

Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo

Linn M, Collnot E, Djuric D, Hempel K, Fabian E, Kolter K, Lehr C (2012)

European Journal of Pharmaceutical Sciences, 45 (3): 336-343DOI: 10.1016/j.ejps.2011.11.025

The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles

Ruge C, Schaefer U, Herrmann J, Kirch J, Cañadas O, Echaide M, Pérez-Gil J, Casals C, Müller R, Lehr C (2012)

PLoS ONE, 7 (7)DOI: 10.1371/journal.pone.0040775

Dissolution techniques for in vitro testing of dry powders for inhalation

May S, Jensen B, Wolkenhauer M, Schneider M, Lehr C (2012)

Pharmaceutical research, 29 (8): 2157-2166DOI: 10.1007/s11095-012-0744-2

Bio-nano interactions in the peripheral lungs

Ruge C (2012)

Book

In vitro characterization of the novel solubility enhancing excipient Soluplus®

Linn M (2012)

Book

The role of fluid dynamics, microstructure and mucociliary clearance in the micro- and macroscopic barrier properties of pulmonary mucus

Kirch J (2012)

Book

Evaluation of finite dose skin absorption experiments with respect to experimental setup and mathematical modelling

Hahn T (2012)

Book

2011

Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A

Ruge C, Kirch J, Cañadas O, Schneider M, Perez-Gil J, Schaefer U, Casals C, Lehr C (2011)

Nanomedicine: Nanotechnology, Biology, and Medicine, 7 (6): 690-693DOI: 10.1016/j.nano.2011.07.009

A new Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) to evaluate pulmonary drug absorption for metered dose dry powder formulations

Hein S, Bur M, Schaefer U, Lehr C (2011)

European Journal of Pharmaceutics and Biopharmaceutics, 77 (1): 132-138DOI: 10.1016/j.ejpb.2010.10.003

Propidium iodide labeling of nanoparticles as a novel tool for the quantification of cellular binding and uptake

Neumeyer A, Bukowski M, Veith M, Lehr C, Daum N (2011)

Nanomedicine: Nanotechnology, Biology, and Medicine, 7 (4): 410-419DOI: 10.1016/j.nano.2010.12.007

Interaction of metal oxide nanoparticles with lung surfactant protein A

Schulze C, Schaefer U, Ruge C, Wohlleben W, Lehr C (2011)

European Journal of Pharmaceutics and Biopharmaceutics, 77 (3): 376-383DOI: 10.1016/j.ejpb.2010.10.013

Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2'-O-methyl-RNA

Dong M, Philippi C, Loretz B, Nafee N, Schaefer U, Friedel G, Ammon-Treiber S, Griese E, Lehr C, Klotz U, Murdter T (2011)

International journal of pharmaceutics, 419 (1-2): 33-42DOI: 10.1016/j.ijpharm.2011.07.009

Improved photostability and reduced skin permeation of tretinoin

Ourique A, Melero A, Silva C, Schaefer U, Pohlmann A, Guterres S, Lehr C, Kostka K, Beck R (2011)

European Journal of Pharmaceutics and Biopharmaceutics, 79 (1): 95-101DOI: 10.1016/j.ejpb.2011.03.008

Transport of Metal Oxide Nanoparticles Across Calu-3 Cell Monolayers Modelling the Air-Blood Barrier

Schulze C, Schaefer U, Voetz M, Wohlleben W, Venzago C, Lehr C (2011)

EURO-NanoTox-Letters, 3 (1): 1-10DOI: 10.1515/entl-2015-0003

Template-assisted polyelectrolyte encapsulation of nanoparticles into dispersible, hierarchically nanostructured microfibers

Kohler D, Schneider M, Krüger M, Lehr C, Möhwald H, Wang D (2011)

Advanced Materials, 23 (11): 1376-1379DOI: 10.1002/adma.201004048

Computational fluid dynamics of nanoparticle disposition in the airways

Kirch J, Guenther M, Schaefer U, Schneider M, Lehr C (2011)

Computing and Visualization in Science, 14 (7): 301-308DOI: 10.1007/s00791-012-0184-x

An in vitro triple cell co-culture model with primary cells mimicking the human alveolar epithelial barrier

Lehmann A, Daum N, Bur M, Lehr C, Gehr P, Rothen-Rutishauser B (2011)

European Journal of Pharmaceutics and Biopharmaceutics, 77 (3): 398-406DOI: 10.1016/j.ejpb.2010.10.014

Enhanced cellular delivery of idarubicin by surface modification of propyl starch nanoparticles employing pteroic acid conjugated polyvinyl alcohol

Jain R, Dandekar P, Loretz B, Melero A, Stauner T, Wenz G, Koch M, Lehr C (2011)

International journal of pharmaceutics, 420 (1): 147-55DOI: 10.1016/j.ijpharm.2011.08.030

Finite dose skin penetration

Naegel A, Hahn T, Schaefer U, Lehr C, Heisig M, Wittum G (2011)

Computing and Visualization in Science, 14 (7): 327-339DOI: 10.1007/s00791-012-0186-8

Selective follicular targeting by modification of the particle sizes

Patzelt A, Richter H, Knorr F, Schäfer U, Lehr C, Dähne L, Sterry W, Lademann J (2011)

Journal of Controlled Release, 150 (1): 45-48DOI: 10.1016/j.jconrel.2010.11.015

Asymmetric particles for pulmonary drug delivery

Kohler D (2011)

Book

Multilayer coating of gold nanoparticles (AuNP) with drug-polymer complex

Reum N (2011)

Book

New models for telomerase inhibition by antisense 2'-O-methyl-RNA in lung cancer therapy

Dong M (2011)

Book

2010

Pulmonary drug delivery

Henning A, Hein S, Schneider M, Bur M, Lehr C (2010)

Book, 197DOI: 10.1007/978-3-642-00477-3_6

Telomerase as an emerging target to fight cancer - Opportunities and challenges for nanomedicine

Philippi C, Loretz B, Schaefer U, Lehr C (2010)

Journal of Controlled Release, 146 (2): 228-240DOI: 10.1016/j.jconrel.2010.03.025

Preparation of elongated polyelectrolyte particles from particles

Kohler D, Schneider M, Lehr C, Krüger M, Möhwald H, Wang D (2010)

European Cells and Materials, 20 (SUPPL.3)

Plant genetic factors for iron homeostasis affect iron bioavailability in Caco-2 cells

Maurer F, Daum N, Schaefer U, Lehr C, Bauer P (2010)

Food Research International, 43 (6): 1661-1665DOI: 10.1016/j.foodres.2010.05.008

Infrared densitometry

Hahn T, Hansen S, Neumann D, Kostka K, Lehr C, Muys L, Schaefer U (2010)

Skin Pharmacology and Physiology, 23 (4): 183-192DOI: 10.1159/000288165

Cellular responses after exposure of lung cell cultures to secondary organic aerosol particles

Gaschen A, Lang D, Kalberer M, Savi M, Geiser T, Gazdhar A, Lehr C, Bur M, Dommen J, Baltensperger U, Geiser M (2010)

Environmental Science and Technology, 44 (4): 1424-1430DOI: 10.1021/es902261m

Drug transport across pulmonary epithelial cell monolayers: effects of particle size, apical liquid volume, and deposition technique

Bur M, Huwer H, Muys L, Lehr C (2010)

Journal of aerosol medicine and pulmonary drug delivery, 23 (3): 119-27DOI: 10.1089/jamp.2009.0757

Vitamin e TPGS P-glycoprotein inhibition mechanism

Collnot E, Baldes C, Schaefer U, Edgar K, Wempe M, Lehr C (2010)

Molecular pharmaceutics, 7 (3): 642-651DOI: 10.1021/mp900191s

Online monitoring of transepithelial electrical resistance (TEER) in an apparatus for combined dissolution and permeation testing

Muendoerfer M, Schaefer U, Koenig P, Walk J, Loos P, Balbach S, Eichinger T, Lehr C (2010)

International journal of pharmaceutics, 392 (1-2): 134-140DOI: 10.1016/j.ijpharm.2010.03.046

Wistar rat skin as surrogate for human skin in nortriptyline hydrochloride patch studies

Melero A, Lehr C, Schäfer U, Garrigues T (2010)

International journal of pharmaceutics, 384 (1-2): 137-139DOI: 10.1016/j.ijpharm.2009.09.028

Multilayer coating of gold nanoparticles with drug-polymer coadsorbates

Reum N, Fink-Straube C, Klein T, Hartmann R, Lehr C, Schneider M (2010)

Langmuir, 26 (22): 16901-16908DOI: 10.1021/la103109b

Nanoparticles made from novel starch derivatives for transdermal drug delivery

Santander-Ortega M, Stauner T, Loretz B, Ortega-Vinuesa J, Bastos-Gonzalez D, Wenz G, Schaefer U, Lehr C (2010)

Journal of controlled release : official journal of the Controlled Release Society, 141 (1): 85-92DOI: 10.1016/j.jconrel.2009.08.012

In vitro and in vivo performance of biocompatible negatively-charged salbutamol-loaded nanoparticles

Rytting E, Bur M, Cartier R, Bouyssou T, Wang X, Krüger M, Lehr C, Kissel T (2010)

Journal of Controlled Release, 141 (1): 101-107DOI: 10.1016/j.jconrel.2009.08.021

Differential cell reaction upon Toll-like receptor 4 and 9 activation in human alveolar and lung interstitial macrophages

Hoppstädter J, Diesel B, Zarbock R, Breinig T, Monz D, Koch M, Meyerhans A, Gortner L, Lehr C, Huwer H, Kiemer A (2010)

Respiratory Research, 11DOI: 10.1186/1465-9921-11-124

A three-dimensional coculture of enterocytes, monocytes and dendritic cells to model inflamed intestinal mucosa in vitro

Leonard F, Collnot E, Lehr C (2010)

Molecular pharmaceutics, 7 (6): 2103-2119DOI: 10.1021/mp1000795

A dynamic ratio of the α+ and α- isoforms of the tight junction protein ZO-1 is characteristic of Caco-2 cells and correlates with their degree of differentiation

Ciana A, Meier K, Daum N, Gerbes S, Veith M, Lehr C, Minetti G (2010)

Cell Biology International, 34 (6): 669-678DOI: 10.1042/CBI20090067

The Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) in vitro system

Hein S, Bur M, Kolb T, Muellinger B, Schaefer U, Lehr C (2010)

ATLA Alternatives to Laboratory Animals, 38 (4): 285-295

Nanoparticle mediated delivery of 2′-O-methyl-RNA leads to efficient telomerase inhibition and telomere shortening in human lung cancer cells

Beisner J, Dong M, Taetz S, Nafee N, Griese E, Schaefer U, Lehr C, Klotz U, Mürdter T (2010)

Lung Cancer, 68 (3): 346-354DOI: 10.1016/j.lungcan.2009.07.010

Influence of particle size and material properties on mucociliary clearance from the airways

Henning A, Schneider M, Nafee N, Muijs L, Rytting E, Wang X, Kissel T, Grafahrend D, Klee D, Lehr C (2010)

Journal of aerosol medicine and pulmonary drug delivery, 23 (4): 233-241DOI: 10.1089/jamp.2009.0806

Calorimetric and spectrophotometric investigation of PLGA nanoparticles and their complex with DNA

Khvedelidze M, Mdzinarashvili T, Partskhaladze T, Nafee N, Schaefer U, Lehr C, Schneider M (2010)

Journal of Thermal Analysis and Calorimetry, 99 (1): 337-348DOI: 10.1007/s10973-009-0137-x

Combined assessment of drug dissolution and epithelial permeability

Mündörfer M (2010)

Book

Pharmaceutical aerosol deposition device on cell cultures (PADDOCC)

Hein S (2010)

Book

The potential of silica nanoparticles as oral drug carriers

Neumeyer A (2010)

Book

Transport of metal oxide nanoparticles across the human air-blood barrier

Schulze C (2010)

Book

2007

Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS

Collnot E, Baldes C, Wempe M, Kappl R, Hüttermann J, Hyatt J, Edgar K, Schaefer U, Lehr C (2007)

Molecular pharmaceutics, 4 (3): 465-474DOI: 10.1021/mp060121r

2004

Preparation and characterization of cationic PLGA nanospheres as DNA carriers

Ravi Kumar M, Bakowsky U, Lehr C (2004)

Biomaterials, 25 (10): 1771-1777DOI: 10.1016/j.biomaterials.2003.08.069

2001

Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa

Lamprecht A, Schäfer U, Lehr C (2001)

Pharmaceutical research, 18 (6): 788-793DOI: 10.1023/A:1011032328064

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