Drug Delivery Across Biological Barriers

Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery

Liu Y, Hamm T, Eichinger T, Kamm W, Wieland H, Loretz B, Hirsch A, Lee S, Lehr C (2024)

Int. J. Nanomedicine 19: 4429-4449DOI: 10.2147/IJN.S448578

A stretchable human lung‐on‐chip model of alveolar inflammation for evaluating anti‐inflammatory drug response

Richter C, Latta L, Harig D, Carius P, Stucki J, Hobi N, Hugi A, Schumacher P, Krebs T, Gamrekeli A, …, Schneider-Daum N, Lehr C (2024)

Bioengineering & Transla MedDOI: 10.1002/btm2.10715

Design and evaluation of nanostructured lipid carrier of Bergenin isolated from Pentaclethra macrophylla for anti-inflammatory effect on lipopolysaccharide-induced inflammatory responses in macrophages

Nnamani P, Nwagwu C, Diovu E, Abonyi O, Nesterkina M, Neu T, Richter C, Loretz B, Lehr C (2024)

Eur J Pharm Biopharm 200DOI: 10.1016/j.ejpb.2024.114307

Biopolymeric and lipid-based nanotechnological strategies for the design and development of novel mosquito repellent systems: recent advances

Nwagwu C, Onugwu A, Echezona A, Uzondu S, Agbo C, Kenechukwu F, Ogbonna J, Ugorji L, Nwobi L, Nwobi O, …, Lehr C, Attama A (2024)

Nanoscale advances 6 (19): 4751-80DOI: 10.1039/d4na00474d

A New Class of Polyion Complex Vesicles (PIC-somes) to Improve Antimicrobial Activity of Tobramycin in Pseudomonas Aeruginosa Biofilms

Yildirim T, Bali A, Koch M, Paul P, Latta L, Schneider-Daum N, Gallei M, Lehr C (2024)

Small (Weinheim an der Bergstrasse, Germany) 20 (40)DOI: 10.1002/smll.202401926

Realizing time-staggered expression of nucleic acid-encoded proteins by co-delivery of messenger RNA and plasmid DNA on a single nanocarrier

Nasr S, Paul P, Loretz B, Lehr C (2024)

Drug delivery and translational research 14 (12): 3339-3353DOI: 10.1007/s13346-024-01668-w

Antimicrobial and antibiotic-potentiating effect of calcium peroxide nanoparticles on oral bacterial biofilms

Bankar N, Latta L, Loretz B, Reda B, Dudek J, Hähl H, Hannig M, Lehr C (2024)

npj Biofilms and Microbiomes 10 (1)DOI: 10.1038/s41522-024-00569-7

A Novel 3D Printed Model of Infected Human Hair Follicles to Demonstrate Targeted Delivery of Nanoantibiotics

Aliyazdi S, Frisch S, Neu T, Veldung B, Karande P, Schaefer U, Loretz B, Vogt T, Lehr C (2024)

ACS biomaterials science & engineering 10 (8): 4947-4957DOI: 10.1021/acsbiomaterials.4c00570

Arg-biodynamers as antibiotic potentiators through interacting with Gram-negative outer membrane lipopolysaccharides

Kamal M, Bassil J, Loretz B, Hirsch A, Lee S, Lehr C (2024)

Eur J Pharm Biopharm 200DOI: 10.1016/j.ejpb.2024.114336

Thermotropic liquid crystals in drug delivery: A versatile carrier for controlled release

Nesterkina M, Kravchenko* I, Hirsch A, Lehr C (2024)

Eur. J. Pharm. Biopharm. 200DOI: 10.1016/j.ejpb.2024.114343

Targeting Intracellular Bacteria with Dual Drug-loaded Lactoferrin Nanoparticles

Andima M, Boese A, Paul P, Koch M, Loretz B, Lehr C (2024)

ACS Infect. Dis.DOI: 10.1021/acsinfecdis.4c00045

Antibiotic resistance and tolerance: What can drug delivery do against this global threat?

Aparicio-Blanco J, Vishwakarma N, Lehr C, Prestidge C, Thomas N, Roberts R, Thorn C, Melero A (2024)

Drug delivery and translational researchDOI: 10.1007/s13346-023-01513-6

Minimum Information for Conducting and Reporting In Vitro Intracellular Infection Assays

Subramaniam S, Joyce P, Ogunniyi A, Dube A, Sampson S, Lehr C, Prestidge C (2024)

ACS Infect. Dis. 10 (2): 337-349DOI: 10.1021/acsinfecdis.3c00613

Drug solubility in biorelevant media in the context of an inhalation-based biopharmaceutics classification system (iBCS)

Floroiu A, Loretz B, Krämer J, Lehr C (2024)

Eur J Pharm Biopharm 197DOI: 10.1016/j.ejpb.2024.114206

Biorelevant subcutaneous in vitro test predicts the release of human and fast acting insulin formulations

Schöner T, Vogel V, Venczel M, Knoth K, Kamm W, Paehler T, Louit G, Terán I, Mundinger P, Marker A, …, Hittinger M, Lehr C (2024)

Int. J. Pharm. 655DOI: 10.1016/j.ijpharm.2024.123995

A Monoclonal Human Alveolar Epithelial Cell Line ("Arlo") with Pronounced Barrier Function for Studying Drug Permeability and Viral Infections

Carius P, Jungmann A, Bechtel M, Grißmer A, Boese A, Gasparoni G, Salhab A, Seipelt R, Urbschat K, Richter C, …, Schneider-Daum N, Lehr C (2023)

Adv. Sci. 10 (8)DOI: 10.1002/advs.202207301

Simulated Tempering-Enhanced Umbrella Sampling Improves Convergence of Free Energy Calculations of Drug Membrane Permeation

Sousa C, Becker R, Lehr C, Kalinina O, Hub J (2023)

Journal of chemical theory and computation 19 (6): 1898-1907DOI: 10.1021/acs.jctc.2c01162

Preparation of Co-Amorphous Levofloxacin Systems for Pulmonary Application

Gabelmann A, Lehr C, Grohganz H (2023)

Pharmaceutics 15 (6)DOI: 10.3390/pharmaceutics15061574

Overview of Inhaled Nanopharmaceuticals

Barthold S, Kunschke N, Murgia X, Loretz B, Carvalho-Wodarz C, Lehr C (2023)

Journal of aerosol medicine and pulmonary drug delivery 36 (3): 144-151DOI: 10.1089/jamp.2023.29089.sb

Cell-Derived Vesicles for Antibiotic Delivery-Understanding the Challenges of a Biogenic Carrier System

Heinrich E, Hartwig O, Walt C, Kardani A, Koch M, Jahromi L, Hoppstädter J, Kiemer A, Loretz B, Lehr C, Fuhrmann G (2023)

Small (Weinheim an der Bergstrasse, Germany) 19 (25)DOI: 10.1002/smll.202207479

Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and stability studies

Arrua E, Hartwig O, Loretz B, Murgia X, Ho D, Bastiat G, Lehr C, Salomon C (2023)

Int. J. Pharm. 642DOI: 10.1016/j.ijpharm.2023.123120

Establishment of an In Bacterio Assay for the Assessment of Carbon Storage Regulator A (CsrA) Inhibitors

Wu Y, Zoller B, Kamal M, Hotop S, Lehr C, Brönstrup M, Dersch P, Empting M (2023)

Chembiochem : a European journal of chemical biology 24 (16)DOI: 10.1002/cbic.202300369

Anti-Inflammatory and Antinociceptive Activity of Herbal Lipospheres of Pentaclethra macrophylla (Fabaceae) Stem Bark Extract

Nnamani P, Diovu E, Peter I, Onwuka A, Ogbuanwu C, Abonyi O, Loretz B, Lehr C (2023)

Processes 11 (9)DOI: 10.3390/pr11092557

Functional Materials to Overcome Bacterial Barriers and Models to Advance Their Development

Bali A, Kamal M, Mulla G, Loretz B, Lehr C (2023)

Advanced Functional Materials 33 (45)DOI: 10.1002/adfm.202304370

3D bioprinting ofE. coliMG1655 biofilms on human lung epithelial cells for building complexin vitroinfection models

Aliyazdi S, Frisch S, Hidalgo A, Frank N, Krug D, Müller R, Schaefer U, Vogt T, Loretz B, Lehr C (2023)

Biofabrication 15 (3)DOI: 10.1088/1758-5090/acd95e

Disrupting Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latent Replication with a Small Molecule Inhibitor

Berwanger A, Stein S, Kany A, Gartner M, Loretz B, Lehr C, Hirsch A, Schulz T, Empting M (2023)

Journal of medicinal chemistry 66 (15): 10782-10790DOI: 10.1021/acs.jmedchem.3c00990

pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA

Liu Y, Ashmawy S, Latta L, Weiss A, Kiefer A, Nasr S, Loretz B, Hirsch A, Lee S, Lehr C (2023)

Biomacromolecules 24 (8): 3742-3754DOI: 10.1021/acs.biomac.3c00424

Thermoresponsive cholesteric liquid-crystal systems doped with terpenoids as drug delivery systems for skin applications

Nesterkina M, Vashchenko O, Vashchenko P, Lisetski L, Kravchenko I, Hirsch A, Lehr C (2023)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.VDOI: 10.1016/j.ejpb.2023.09.002

Improving the oral delivery of benznidazole nanoparticles by optimizing the formulation parameters through a design of experiment and optimization strategy

Arrua E, Hartwig O, Loretz B, Goicoechea H, Murgia X, Lehr C, Salomon C (2022)

Colloids and surfaces. B, Biointerfaces 217DOI: 10.1016/j.colsurfb.2022.112678

Modeling the Effect of Hydrophobicity on the Passive Permeation of Solutes across a Bacterial Model Membrane

Sousa C, Kamal M, Richter R, Elamaldeniya K, Hartmann R, Empting M, Lehr C, Kalinina O (2022)

Journal of chemical information and modeling 62 (20): 5023-5033DOI: 10.1021/acs.jcim.2c00767

Lipid-Polymer Hybrid Nanoparticles for mRNA Delivery to Dendritic Cells: Impact of Lipid Composition on Performance in Different Media

Kliesch L, Delandre S, Gabelmann A, Koch M, Schulze K, Guzmán C, Loretz B, Lehr C (2022)

Pharmaceutics 14 (12)DOI: 10.3390/pharmaceutics14122675

Intracellular Dynamics of Extracellular Vesicles by Segmented Trajectory Analysis

Rautaniemi K, John T, Richter M, Huck B, Zini J, Loretz B, Lehr C, Vuorimaa-Laukkanen E, Lisitsyna E, Laaksonen T (2022)

Analytical chemistry 94 (51): 17770-17778DOI: 10.1021/acs.analchem.2c02928

Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape

Lee S, Nasr S, Rasheed S, Liu Y, Hartwig O, Kaya C, Boese A, Koch M, Herrmann J, Müller R, …, Hirsch A, Lehr C (2022)

Journal of controlled release : official journal of the Controlled Release Society 353: 915-929DOI: 10.1016/j.jconrel.2022.12.018

Leaky gut model of the human intestinal mucosa for testing siRNA-based nanomedicine targeting JAK1

Hartwig O, Loretz B, Nougarede A, Jary D, Sulpice E, Gidrol X, Navarro F, Lehr C (2022)

J Control Release 345: 646-660DOI: 10.1016/j.jconrel.2022.03.037

Themed issue: Extracellular vesicles in drug delivery and bioengineering

Fuhrmann G, Lehr C, Schiffelers R (2022)

Advanced Drug Delivery Reviews 181DOI: 10.1016/j.addr.2021.114073

An Outer Membrane Vesicle-Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability

Richter R, Kamal M, Koch M, Niebuur B, Huber A, Goes A, Volz C, Vergalli J, Kraus T, Müller R, …, Pagès J, Lehr C (2022)

Advanced healthcare materials 11 (5)DOI: 10.1002/adhm.202101180

Targeting extracellular lectins of Pseudomonas aeruginosa with glycomimetic liposomes

Metelkina O, Huck B, O'Connor J, Koch M, Manz A, Lehr C, Titz A (2022)

Journal of Materials Chemistry B 10 (4): 537-548DOI: 10.1039/d1tb02086b

Nano-in-Microparticles for Aerosol Delivery of Antibiotic-Loaded, Fucose-Derivatized, and Macrophage-Targeted Liposomes to Combat Mycobacterial Infections: In Vitro Deposition, Pulmonary Barrier Interactions, and Targeted Delivery

Huck B, Thiyagarajan D, Bali A, Boese A, Besecke K, Hozsa C, Gieseler R, Furch M, Carvalho-Wodarz C, Waldow F, …, Loretz B, Lehr C (2022)

Advanced healthcare materials 11 (11)DOI: 10.1002/adhm.202102117

Spray-dried pneumococcal membrane vesicles are promising candidates for pulmonary immunization

Mehanny M, Boese A, Bornamehr B, Hoppstädter J, Presser V, Kiemer A, Lehr C, Fuhrmann G (2022)

International journal of pharmaceutics 621DOI: 10.1016/j.ijpharm.2022.121794

Transferring Microclusters of P. aeruginosa Biofilms to the Air-Liquid Interface of Bronchial Epithelial Cells for Repeated Deposition of Aerosolized Tobramycin

Horstmann J, Laric A, Boese A, Yildiz D, Röhrig T, Empting M, Frank N, Krug D, Müller R, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2022)

ACS infectious diseases 8 (1): 137-149DOI: 10.1021/acsinfecdis.1c00444

Yields and Immunomodulatory Effects of Pneumococcal Membrane Vesicles Differ with the Bacterial Growth Phase

Mehanny M, Kroniger T, Koch M, Hoppstädter J, Becher D, Kiemer A, Lehr C, Fuhrmann G (2022)

Advanced healthcare materials 11 (5)DOI: 10.1002/adhm.202101151

Exploring the permeation of fluoroquinolone metalloantibiotics across outer membrane porins by combining molecular dynamics simulations and a porin-mimetic in vitro model

Sousa C, Coimbra J, Richter R, Morais-Cabral J, Ramos M, Lehr C, Fernandes P, Gameiro P (2022)

Biochimica et biophysica acta. Biomembranes 1864 (3)DOI: 10.1016/j.bbamem.2021.183838

Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: Composition, structure and barrier properties

Huck B, Murgia X, Frisch S, Hittinger M, Hidalgo A, Loretz B, Lehr C (2022)

Advanced Drug Delivery Reviews 183DOI: 10.1016/j.addr.2022.114141

Towards the sustainable discovery and development of new antibiotics

Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo P, Glaser P, Aigle B, Bode H, …, Moser H, Müller R (2021)

Nature reviews. Chemistry 5 (10): 726-749DOI: 10.1038/s41570-021-00313-1

Surfactant-Free Glibenclamide Nanoparticles: Formulation, Characterization and Evaluation of Interactions with Biological Barriers

Arrua E, Hartwig O, Ho D, Loretz B, Murgia X, Salomon C, Lehr C (2021)

Pharmaceutical research 38 (6): 1081-1092DOI: 10.1007/s11095-021-03056-2

PerfuPul-A Versatile Perfusable Platform to Assess Permeability and Barrier Function of Air Exposed Pulmonary Epithelia

Carius P, Dubois A, Ajdarirad M, Artzy-Schnirman A, Sznitman J, Schneider-Daum N, Lehr C (2021)

Frontiers in Bioengineering and Biotechnology 9DOI: 10.3389/fbioe.2021.743236

Pulmonary in vitro instruments for the replacement of animal experiments

Primavessy D, Metz J, Schnur S, Schneider M, Lehr C, Hittinger M (2021)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 168: 62-75DOI: 10.1016/j.ejpb.2021.08.005

Co-Delivery of mRNA and pDNA Using Thermally Stabilized Coacervate-Based Core-Shell Nanosystems

Nasr S, Lee S, Thiyagarajan D, Boese A, Loretz B, Lehr C (2021)

Pharmaceutics 13 (11)DOI: 10.3390/pharmaceutics13111924

A pulmonary mucus surrogate for investigating antibiotic permeation and activity against Pseudomonas aeruginosa biofilms

Frisch S, Boese A, Huck B, Horstmann J, Ho D, Schwarzkopf K, Murgia X, Loretz B, Souza Carvalho-Wodarz C, Lehr C (2021)

The Journal of antimicrobial chemotherapy 76 (6): 1472-1479DOI: 10.1093/jac/dkab068

Formulation and evaluation of transdermal nanogel for delivery of artemether

Nnamani P, Ugwu A, Nnadi O, Kenechukwu F, Ofokansi K, Attama A, Lehr C (2021)

Drug delivery and translational research 11 (4): 1655-1674DOI: 10.1007/s13346-021-00951-4

Analysis and Optimization of Two Film-Coated Tablet Production Processes by Computer Simulation: A Case Study

Hering S, Schäuble N, Buck T, Loretz B, Rillmann T, Stieneker F, Lehr C (2021)

Processes 9 (1)DOI: 10.3390/pr9010067

Tobramycin Liquid Crystal Nanoparticles Eradicate Cystic Fibrosis-Related Pseudomonas aeruginosa Biofilms

Thorn C, Carvalho-Wodarz C, Horstmann J, Lehr C, Prestidge C, Thomas N (2021)

Small (Weinheim an der Bergstrasse, Germany) 17 (24)DOI: 10.1002/smll.202100531

Drug delivery to the inflamed intestinal mucosa- targeting technologies and human cell culture models for better therapies of IBD

Olga H, Shetab Boushehri Maryam A, Shalaby Karim S, Brigitta L, Alf L, Claus-Michael L (2021)

Advanced Drug Delivery ReviewsDOI: 10.1016/j.addr.2021.113828

Human Skin Permeation Enhancement Using PLGA Nanoparticles Is Mediated by Local pH Changes

Luengo J, Schneider M, Schneider A, Lehr C, Schaefer U (2021)

Pharmaceutics 13 (10)DOI: 10.3390/pharmaceutics13101608

Drug delivery for fighting infectious diseases: a global perspective

Loretz B, Oh Y, Hudson S, Gu Z, Lehr C (2021)

Drug delivery and translational research 11 (4): 1316-1322DOI: 10.1007/s13346-021-01009-1

Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane

Zamprogno P, Wüthrich S, Achenbach S, Thoma G, Stucki J, Hobi N, Schneider-Daum N, Lehr C, Huwer H, Geiser T, Schmid R, Guenat O (2021)

Communications Biology 4 (1)DOI: 10.1038/s42003-021-01695-0

Development and evaluation of a quality control system based on transdermal electrical resistance for skin barrier function in vitro

Knoth K, Zäh R, Veldung B, Burgio D, Wiegand B, Smola H, Bock U, Lehr C, Hittinger M, Groß H (2021)

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)DOI: 10.1111/srt.12998

Fucosylated lipid nanocarriers loaded with antibiotics efficiently inhibit mycobacterial propagation in human myeloid cells

Durán V, Grabski E, Hozsa C, Becker J, Yasar H, Monteiro J, Costa B, Koller N, Lueder Y, Wiegmann B, …, Graalmann T, Kalinke U (2021)

Journal of controlled release : official journal of the Controlled Release Society 334: 201-212DOI: 10.1016/j.jconrel.2021.04.012

Microbiota and cancer: In vitro and in vivo models to evaluate nanomedicines

Ladaycia A, Loretz B, Passirani C, Lehr C, Lepeltier E (2021)

Advanced Drug Delivery Reviews 170: 44-70DOI: 10.1016/j.addr.2020.12.015

A Custom-Made Device for Reproducibly Depositing Pre-metered Doses of Nebulized Drugs on Pulmonary Cells in vitro

Horstmann J, Thorn C, Carius P, Graef F, Murgia X, Souza Carvalho-Wodarz C, Lehr C (2021)

Frontiers in Bioengineering and Biotechnology 9DOI: 10.3389/fbioe.2021.643491

Testing of aerosolized ciprofloxacin nanocarriers on cystic fibrosis airway cells infected with P. aeruginosa biofilms

Juntke J, Murgia X, Günday Türeli N, Türeli A, Thorn C, Schneider M, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2021)

Drug delivery and translational research 11 (4): 1752-1765DOI: 10.1007/s13346-021-01002-8

Decoding (patho-)physiology of the lung by advanced in vitro models for developing novel anti-infectives therapies

Montefusco-Pereira C, Carvalho-Wodarz C, Seeger J, Kloft C, Michelet R, Lehr C (2021)

Drug Discovery Today 26 (1): 148-163DOI: 10.1016/j.drudis.2020.10.016

A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms

Schütz C, Ho D, Hamed M, Abdelsamie A, Röhrig T, Herr C, Kany A, Rox K, Schmelz S, Siebenbürger L, …, Lehr C, Empting M (2021)

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8 (12)DOI: 10.1002/advs.202004369

Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals

Thiyagarajan D, Huck B, Nothdurft B, Koch M, Rudolph D, Rutschmann M, Feldmann C, Hozsa C, Furch M, Besecke K, …, Loretz B, Lehr C (2021)

Drug delivery and translational research 11 (4): 1766-1778DOI: 10.1007/s13346-021-01011-7

Extracellular vesicles as antigen carriers for novel vaccination avenues

Mehanny M, Lehr C, Fuhrmann G (2021)

Advanced Drug Delivery Reviews 173: 164-180DOI: 10.1016/j.addr.2021.03.016

Extracellular vesicles as novel assay tools to study cellular interactions of anti-infective compounds - A perspective

Richter R, Lehr C (2021)

Advanced Drug Delivery Reviews 173: 492-503DOI: 10.1016/j.addr.2021.04.010

Disease Models: Lung Models for Testing Drugs Against Inflammation and Infection

Carius P, Horstmann J, Souza Carvalho-Wodarz C, Lehr C (2021)

Handbook of experimental pharmacology 265: 157-186DOI: 10.1007/164_2020_366

Eap-functionalized liposomes as a bioinspired delivery system for oral delivery of colistin to treat intracellular Salmonella infection

Menina S (2021)

Book

Mastering the Gram-Negative Bacterial Barrier - Chemical Approaches to Increase Bacterial Bioavailability of Antibiotics

Ropponen H, Richter R, Hirsch A, Lehr C (2021)

Advanced Drug Delivery ReviewsDOI: 10.1016/j.addr.2021.02.014

Tobacco Smoke and Inhaled Drugs Alter Expression and Activity of Multidrug Resistance-Associated Protein-1 (MRP1) in Human Distal Lung Epithelial Cells in vitro

Selo M, Delmas A, Springer L, Zoufal V, Sake J, Clerkin C, Huwer H, Schneider-Daum N, Lehr C, Nickel S, Langer O, Ehrhardt C (2020)

Frontiers in Bioengineering and Biotechnology 8DOI: 10.3389/fbioe.2020.01030

Towards a Continuous Manufacturing Process of Protein-Loaded Polymeric Nanoparticle Powders

Schiller S, Hanefeld A, Schneider M, Lehr C (2020)

AAPS PharmSciTech 21 (7)DOI: 10.1208/s12249-020-01814-w

A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria

Richter R, Kamal M, García-Rivera M, Kaspar J, Junk M, Elgaher W, Srikakulam S, Gress A, Beckmann A, Grißmer A, …, Schneider-Daum N, Lehr C (2020)

Materials today. Bio 8DOI: 10.1016/j.mtbio.2020.100084

Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection

Murgia X, Kany A, Herr C, Ho D, Rossi C, Bals R, Lehr C, Hirsch A, Hartmann R, Empting M, Röhrig T (2020)

Scientific Reports 10 (1)DOI: 10.1038/s41598-020-73459-5

Modulating the Barrier Function of Human Alveolar Epithelial (hAELVi) Cell Monolayers as a Model of Inflammation

Metz J, Wiegand B, Schnur S, Knoth K, Schneider-Daum N, Groß H, Croston G, Reinheimer T, Lehr C, Hittinger M (2020)

Alternatives to laboratory animals : ATLA 48 (5-6): 252-267DOI: 10.1177/0261192920983015

Spray-dried multidrug particles for pulmonary co-delivery of antibiotics with N-acetylcysteine and curcumin-loaded PLGA-nanoparticles

Lababidi N, Montefusco-Pereira C, Souza Carvalho-Wodarz C, Lehr C, Schneider M (2020)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 157: 200-210DOI: 10.1016/j.ejpb.2020.10.010

Synthesis and Biopharmaceutical Characterization of Amphiphilic Squalenyl Derivative Based Versatile Drug Delivery Platform

Ho D, Christmann R, Murgia X, Rossi C, Frisch S, Koch M, Schaefer U, Loretz B, Desmaele D, Couvreur P, Lehr C (2020)

Frontiers in chemistry 8DOI: 10.3389/fchem.2020.584242

Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases

Christmann R, Ho D, Wilzopolski J, Lee S, Koch M, Loretz B, Vogt T, Bäumer W, Schaefer U, Lehr C (2020)

Pharmaceutics 12 (12)DOI: 10.3390/pharmaceutics12121131

Predicting Bacterial Accumulation of Anti-infectives by Measuring Permeability across Surrogates of the Gram-negative Bacterial Cell Envelope

Richter R (2020)

Book

Predicting Bacterial Accumulation of Anti-infectives by Measuring Permeability across Surrogates of the Gram-negative Bacterial Cell Envelope

Richter R (2020)

Book

PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus

Anversa Dimer F, Souza Carvalho-Wodarz C, Goes A, Cirnski K, Herrmann J, Schmitt V, Pätzold L, Abed N, Rossi C, Bischoff M, …, Müller R, Lehr C (2020)

Nanomedicine : nanotechnology, biology, and medicine 24DOI: 10.1016/j.nano.2019.102125

Advancing human in vitro pulmonary disease models in preclinical research: opportunities for lung-on-chips

Artzy-Schnirman A, Lehr C, Sznitman J (2020)

Expert Opinion on Drug Delivery 17 (5): 621-625DOI: 10.1080/17425247.2020.1738380

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives

Montefusco-Pereira C, Horstmann J, Ebensen T, Beisswenger C, Bals R, Guzmán C, Schneider-Daum N, Carvalho-Wodarz C, Lehr C (2020)

Journal of visualized experiments : JoVE (160)DOI: 10.3791/61069

Safety assessment of excipients (SAFE) for orally inhaled drug products

Metz J, Scharnowske L, Hans F, Schnur S, Knoth K, Zimmer H, Limberger M, Groß H, Lehr C, Hittinger M (2020)

ALTEX 37 (2): 275-286DOI: 10.14573/altex.1910231

Nanoparticle Targeting to Scalp Hair Follicles: New Perspectives for a Topical Therapy for Alopecia Areata

Christmann R, Thomas C, Jager N, Raber A, Loretz B, Schaefer U, Tschernig T, Vogt T, Lehr C (2020)

The Journal of investigative dermatology 140 (1): 243-246DOI: 10.1016/j.jid.2019.05.028

pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers

Lee S, Kaya C, Jang H, Koch M, Loretz B, Buhler E, Lehr C, Hirsch A (2020)

Mater. Chem. Front. 4 (3): 905-909DOI: 10.1039/C9QM00651F

Itaconic Acid Increases the Efficacy of Tobramycin against Pseudomonas aeruginosa Biofilms

Ho D, Rossi C, Loretz B, Murgia X, Lehr C (2020)

Pharmaceutics 12 (8)DOI: 10.3390/pharmaceutics12080691

Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections

Ho D, Murgia X, Rossi C, Christmann R, Hüfner de Mello Martins A, Koch M, Andreas A, Herrmann J, Müller R, Empting M, …, Couvreur P, Lehr C (2020)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202001407

Design and in vitro characterization of multistage silicon-PLGA budesonide particles for inflammatory bowel disease

Leonard F, Srinivasan S, Liu X, Collnot E, Ferrari M, Lehr C, Godin B (2020)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 151: 61-72DOI: 10.1016/j.ejpb.2020.03.020

3D air-liquid interface culture of Cystic Fibrosis bronchial epithelia, macrophages and P. aeruginosa to assess host-pathogen interaction and drug efficacy

Montefusco C, Montefusco-Pereira C (2020)

BookDOI: 10.22028/D291-31815

Inhalationstoxizität von Nanopartikeln // The role of alveolar macrophages in biokinetics and biological effects of inhaled nanoparticles

Koltermann-Jülly J (2020)

BookDOI: 10.22028/D291-31034

Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility

Montefusco-Pereira C, Formicola B, Goes A, Re F, Marrano C, Mantegazza F, Carvalho-Wodarz C, Fuhrmann G, Caneva E, Nicotra F, Lehr C, Russo L (2020)

European Journal of Pharmaceutics and Biopharmaceutics 149: 12-20DOI: 10.1016/j.ejpb.2020.01.013

Streptococcal Extracellular Membrane Vesicles Are Rapidly Internalized by Immune Cells and Alter Their Cytokine Release

Mehanny M, Koch M, Lehr C, Fuhrmann G (2020)

Frontiers in immunology 11DOI: 10.3389/fimmu.2020.00080

Macro- and Microrheological Properties of Mucus Surrogates in Comparison to Native Intestinal and Pulmonary Mucus

Huck B, Hartwig O, Biehl A, Schwarzkopf K, Wagner C, Loretz B, Murgia X, Lehr C (2019)

Biomacromolecules 20 (9): 3504-3512DOI: 10.1021/acs.biomac.9b00780

Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier

Costa A, Souza Carvalho-Wodarz C, Seabra V, Sarmento B, Lehr C (2019)

Acta BiomaterialiaDOI: 10.1016/j.actbio.2019.04.037

Challenges and Strategies in Drug Delivery Systems for Treatment of Pulmonary Infections

Ho D, Nichols B, Edgar K, Murgia X, Loretz B, Lehr C (2019)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.VDOI: 10.1016/j.ejpb.2019.09.002

Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline

Artzy-Schnirman A, Hobi N, Schneider-Daum N, Guenat O, Lehr C, Sznitman J (2019)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 144: 11-17DOI: 10.1016/j.ejpb.2019.09.006

OCTN2-Mediated Acetyl-l-Carnitine Transport in Human Pulmonary Epithelial Cells In Vitro

Salomon J, Gausterer J, Selo M, Hosoya K, Huwer H, Schneider-Daum N, Lehr C, Ehrhardt C (2019)

Pharmaceutics 11 (8)DOI: 10.3390/pharmaceutics11080396

Preparation, characterization and in vitro antibacterial property of Ciprofloxacin-loaded nanostructured lipid carrier for treatment of Bacillus subtilis infection

Nnamani P, Ugwu A, Ibezim E, Onoja S, Odo A, Windbergs M, Rossi C, Lehr C, Attama A (2019)

Journal of Microencapsulation: 1-30DOI: 10.1080/02652048.2019.1582724

Capturing the Onset of Bacterial Pulmonary Infection in Acini‐On‐Chips

Artzy-Schnirman A, Zidan H, Elias-Kirma S, Ben-Porat L, Tenenbaum-Katan J, Carius P, Fishler R, Schneider-Daum N, Lehr C, Sznitman J (2019)

Adv. Biosys. 3 (9)DOI: 10.1002/adbi.201900026

The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

Formicola B, Dal Magro R, Montefusco-Pereira C, Lehr C, Koch M, Russo L, Grasso G, Deriu M, Danani A, Bourdoulous S, Re F (2019)

Journal of nanobiotechnology 17 (1)DOI: 10.1186/s12951-019-0546-3

Bioinspired Liposomes for Oral Delivery of Colistin to Combat Intracellular Infections by Salmonella enterica

Menina S, Eisenbeis J, Kamal M, Koch M, Bischoff M, Gordon S, Loretz B, Lehr C (2019)

Advanced healthcare materials 8 (17)DOI: 10.1002/adhm.201900564

Preferential uptake of chitosan-coated PLGA nanoparticles by primary human antigen presenting cells

Durán V, Yasar H, Becker J, Thiyagarajan D, Loretz B, Kalinke U, Lehr C (2019)

Nanomedicine : nanotechnology, biology, and medicine 21DOI: 10.1016/j.nano.2019.102073

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

Thanki K, van Eetvelde D, Geyer A, Fraire J, Hendrix R, van Eygen H, Putteman E, Sami H, Souza Carvalho-Wodarz C, Franzyk H, …, Ogris M, Foged C (2019)

Journal of controlled release : official journal of the Controlled Release Society 310: 82-93DOI: 10.1016/j.jconrel.2019.08.004

Non-invasive vaccination by nanoparticle-based messenger RNA (mRNA) delivery via the transfollicular route

Yasar H (2019)

UnpublishedWorkDOI: 10.22028/D291-27933

Interaction of nanoparticles with the pulmonary barrier; The role of mucus in health and disease // The Role of Airway Mucus as a Barrier to Nanoparticles: Implications for Pulmonary Drug Delivery

Murgia X, Murgia Esteve X (2019)

BookDOI: 10.22028/D291-31240

Pseudobacterial nanocarriers for intracellular delivery of anti-infectives

Castoldi A (2019)

UnpublishedWorkDOI: 10.22028/D291-27989

Author Correction: Extracellular vesicles protect glucuronidase model enzymes during freeze-drying (Scientific Reports, (2018), 8, 1, (12377), 10.1038/s41598-018-30786-y)

Frank J, Richter M, Rossi C, Lehr C, Fuhrmann K, Fuhrmann G (2019)

Scientific Reports 9 (1)DOI: 10.1038/s41598-019-48221-1

Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles

Yasar H, Biehl A, Rossi C, Koch M, Murgia X, Loretz B, Lehr C (2018)

Journal of nanobiotechnology 16 (1)DOI: 10.1186/s12951-018-0401-y

Can lifecycle management safeguard innovation in the pharmaceutical industry?

Hering S, Loretz B, Friedli T, Lehr C, Stieneker F (2018)

Drug Discovery TodayDOI: 10.1016/j.drudis.2018.10.008

The role of mucus on drug transport and its potential to affect therapeutic outcomes

Murgia X, Loretz B, Hartwig O, Hittinger M, Lehr C (2018)

Advanced Drug Delivery Reviews 124: 82-97DOI: 10.1016/j.addr.2017.10.009

Oral delivery of macromolecular drugs

Savla R, Hartwig O, Lim Chin W, Loretz B, Lehr C (2018)

Pharm. Technol. Eur. 30 (7): 22-26

Vibrational spectroscopic imaging and live cell video microscopy for studying differentiation of primary human alveolar epithelial cells

Vukosavljevic B, Hittinger M, Hachmeister H, Pilger C, Murgia X, Gepp M, Gentile L, Huwer H, Schneider-Daum N, Huser T, Lehr C, Windbergs M (2018)

Journal of biophotonicsDOI: 10.1002/jbio.201800052

Human airway mucus alters susceptibility of Pseudomonas aeruginosa biofilms to tobramycin, but not colistin

Müller L, Murgia X, Siebenbürger L, Börger C, Schwarzkopf K, Sewald K, Häussler S, Braun A, Lehr C, Hittinger M, Wronski S (2018)

The Journal of antimicrobial chemotherapy 73 (10): 2762-2769DOI: 10.1093/jac/dky241

Farnesylated Glycol Chitosan as a Platform for Drug Delivery

Ho D, Frisch S, Biehl A, Terriac E, Rossi C, Schwarzkopf K, Lautenschläger F, Loretz B, Murgia X, Lehr C (2018)

Biomacromolecules 19 (8): 3489-3501DOI: 10.1021/acs.biomac.8b00795

Chemically modified h CFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis

Haque, A. K. M. Ashiqul, Dewerth A, Antony J, Riethmüller J, Schweizer G, Weinmann P, Latifi N, Yasar H, Pedemonte N, …, Handgretinger R, Kormann M (2018)

Scientific Reports 8 (1)DOI: 10.1038/s41598-018-34960-0

In Vitro Model of the Gram-Negative Bacterial Cell Envelope for Investigation of Anti-Infective Permeation Kinetics

Graef F, Richter R, Fetz V, Murgia X, Rossi C, Schneider-Daum N, Allegretta G, Elgaher W, Haupenthal J, Empting M, …, Gordon S, Lehr C (2018)

ACS infectious diseases 4 (8): 1188-1196DOI: 10.1021/acsinfecdis.7b00165

Polysaccharide Submicrocarrier for Improved Pulmonary Delivery of Poorly Soluble Anti-infective Ciprofloxacin

Ho D, Costa A, Rossi C, Souza Carvalho-Wodarz C, Loretz B, Lehr C (2018)

Molecular pharmaceutics 15 (3): 1081-1096DOI: 10.1021/acs.molpharmaceut.7b00967

Combining MucilAir™ and Vitrocell® Powder Chamber for the In Vitro Evaluation of Nasal Ointments in the Context of Aerosolized Pollen

Metz J, Knoth K, Groß H, Lehr C, Stäbler C, Bock U, Hittinger M (2018)

Pharmaceutics 10 (2)DOI: 10.3390/pharmaceutics10020056

A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes

Serr I, Scherm M, Zahm A, Schug J, Flynn V, Hippich M, Kälin S, Becker M, Achenbach P, Nikolaev A, …, Ziegler A, Daniel C (2018)

Science translational medicine 10 (422)DOI: 10.1126/scitranslmed.aag1782

Co-culture of human alveolar epithelial (hAELVi) and macrophage (THP-1) cell lines

Kletting S, Barthold S, Repnik U, Griffiths G, Loretz B, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2018)

ALTEX 35 (2): 211-222DOI: 10.14573/altex.1607191

Starch-Chitosan Polyplexes

Yasar H, Ho D, Rossi C, Herrmann J, Gordon S, Loretz B, Lehr C (2018)

Polymers 10 (3)DOI: 10.3390/polym10030252

Towards Standardized Dissolution Techniques for In Vitro Performance Testing of Dry Powder Inhalers

Floroiu A, Klein M, Krämer J, Lehr C (2018)

Dissolution Technologies 25 (3): 6-18DOI: 10.14227/DT250318P6

Medium throughput breathing human primary cell alveolus-on-chip model

Stucki J, Hobi N, Galimov A, Stucki A, Schneider-Daum N, Lehr C, Huwer H, Frick M, Funke-Chambour M, Geiser T, Guenat O (2018)

Scientific Reports 8 (1)DOI: 10.1038/s41598-018-32523-x

Murine alveolar epithelial cells and their lentivirus-mediated immortalisation

Sapich S, Hittinger M, Hendrix-Jastrzebski R, Repnik U, Griffiths G, May T, Wirth D, Bals R, Schneider-Daum N, Lehr C (2018)

Alternatives to laboratory animals : ATLA 46 (2): 73-89

Postmenopausaler Lichen planopilaris alias fibrosierende frontotemporale Alopezie Kossard

Vogt T, Thomas C, Reichrath J, Schilling L, Mawlood D, Christmann R, Loretz B, Schäfer U, Lehr C, Müller C (2018)

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 69 (2): 134-142DOI: 10.1007/s00105-017-4118-x

A novel co-culture model of human bronchial epithelial cells and Pseudomonas aeruginosa biofilms to mimic chronic lung infections in cystic fibrosis

Juntke J (2018)

UnpublishedWorkDOI: 10.22028/D291-27897

Novel anti-infective delivery systems for the treatment of pulmonary bacterial infections

Ho D (2018)

UnpublishedWorkDOI: 10.22028/D291-27854

Aspherical and Spherical InvA497-Functionalized Nanocarriers for Intracellular Delivery of Anti-Infective Agents

Castoldi A, Empting M, Rossi C, Mayr K, Dersch P, Hartmann R, Müller R, Gordon S, Lehr C (2018)

Pharm Res 36 (1)DOI: 10.1007/s11095-018-2521-3

Extracellular vesicles protect glucuronidase model enzymes during freeze-drying

Frank J, Richter M, Rossi C, Lehr C, Fuhrmann K, Fuhrmann G (2018)

Scientific Reports 8 (1)DOI: 10.1038/s41598-018-30786-y

Increased survival and proliferation of the epidemic strain Mycobacterium abscessus subsp. massiliense CRM0019 in alveolar epithelial cells

Ribeiro G, Matsumoto C, Real F, Teixeira D, Duarte R, Mortara R, Leão S, Souza Carvalho-Wodarz C (2017)

BMC microbiology 17 (1)DOI: 10.1186/s12866-017-1102-7

3D printed tablets loaded with polymeric nanocapsules: An innovative approach to produce customized drug delivery systems

Beck R, Chaves P, Goyanes A, Vukosavljevic B, Buanz A, Windbergs M, Basit A, Gaisford S (2017)

International journal of pharmaceutics 528 (1-2): 268-279DOI: 10.1016/j.ijpharm.2017.05.074

Functional electrospun fibers for the treatment of human skin wounds

Wang J, Windbergs M (2017)

European Journal of Pharmaceutics and BiopharmaceuticsDOI: 10.1016/j.ejpb.2017.07.001

Controlling the Release of Proteins from Therapeutic Nanofibers: The Effect of Fabrication Modalities on Biocompatibility and Antimicrobial Activity of Lysozyme

Seif S, Planz V, Windbergs M (2017)

Planta medica 83 (5): 445-452DOI: 10.1055/s-0042-109715

Redispersible spray-dried lipid-core nanocapsules intended for oral delivery

Andrade D, Vukosavljevic B, Benvenutti E, Pohlmann A, Guterres S, Windbergs M, Beck R (2017)

Pharmaceutical development and technology: 1-12DOI: 10.1080/10837450.2017.1400559

Delivery of Therapeutic Proteins Using Electrospun Fibers-Recent Developments and Current Challenges

Seif S, Planz V, Windbergs M (2017)

Archiv der Pharmazie 350 (10)DOI: 10.1002/ardp.201700077

Circulating Lipoproteins: A Trojan Horse Guiding Squalenoylated Drugs to LDL-Accumulating Cancer Cells

Sobot D, Mura S, Rouquette M, Vukosavljevic B, Cayre F, Buchy E, Pieters G, Garcia-Argote S, Windbergs M, Desmaële D, Couvreur P (2017)

Molecular therapy : the journal of the American Society of Gene Therapy 25 (7): 1596-1605DOI: 10.1016/j.ymthe.2017.05.016

Permanent gene correction by means of nucleotide-modified messenger RNA

Kormann M, Lehr C, Loretz B, Malaeksefat E (2017)

Patent (DE/08.10.13/ DEA102013111099)

Cell and tissue-based in vitro models for improving the development of oral inhalation drug products

Hittinger M, Schneider-Daum N, Lehr C (2017)

European Journal of Pharmaceutics and Biopharmaceutics 118: 73-78DOI: 10.1016/j.ejpb.2017.02.019

Nanoencapsulation of a glucocorticoid improves barrier function and anti-inflammatory effect on monolayers of pulmonary epithelial cell lines

Rigo L, Carvalho-Wodarz C, Pohlmann A, Guterres S, Schneider-Daum N, Lehr C, Beck R (2017)

European Journal of Pharmaceutics and BiopharmaceuticsDOI: 10.1016/j.ejpb.2017.05.006

Modelling the bronchial barrier in pulmonary drug delivery

Murgia X, Yasar H, Carvalho-Wodarz C, Loretz B, Gordon S, Schwarzkopf K, Schaefer U, Lehr C (2017)

European Journal of Pharmaceutics and Biopharmaceutics 118: 79-88DOI: 10.1016/j.ejpb.2017.03.020

Targeted delivery of Cyclosporine A by polymeric nanocarriers improves the therapy of inflammatory bowel disease in a relevant mouse model

Melero A, Draheim C, Hansen S, Giner E, Carreras J, Talens-Visconti R, Garrigues T, Peris J, Recio M, Giner R, Lehr C (2017)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 119: 361-371DOI: 10.1016/j.ejpb.2017.07.004

Expression and Activity of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Distal Lung Epithelial Cells In Vitro

Nickel S, Selo M, Fallack J, Clerkin C, Huwer H, Schneider-Daum N, Lehr C, Ehrhardt C (2017)

Pharmaceutical researchDOI: 10.1007/s11095-017-2172-9

Tracing molecular and structural changes upon mucolysis with N-acetyl cysteine in human airway mucus

Vukosavljevic B, Murgia X, Schwarzkopf K, Schaefer U, Lehr C, Windbergs M (2017)

International journal of pharmaceutics 533 (2): 373-376DOI: 10.1016/j.ijpharm.2017.07.022

Biodegradable starch derivatives with tunable charge density-synthesis, characterization, and transfection efficiency

Thiele C, Loretz B, Lehr C (2017)

Drug delivery and translational research 7 (2): 252-258DOI: 10.1007/s13346-016-0333-8

Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections

Castoldi A, Herr C, Niederstraßer J, Labouta H, Melero A, Gordon S, Schneider-Daum N, Bals R, Lehr C (2017)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 118: 62-67DOI: 10.1016/j.ejpb.2016.11.026

A Model for the Transient Subdiffusive Behavior of Particles in Mucus

Ernst M, John T, Guenther M, Wagner C, Schaefer U, Lehr C (2017)

Biophysical journal 112 (1): 172-179DOI: 10.1016/j.bpj.2016.11.900

Ciprofloxacin-loaded PLGA nanoparticles against cystic fibrosis P. aeruginosa lung infections

Günday Türeli N, Torge A, Juntke J, Schwarz B, Schneider-Daum N, Türeli A, Lehr C, Schneider M (2017)

European Journal of Pharmaceutics and Biopharmaceutics 117: 363-371DOI: 10.1016/j.ejpb.2017.04.032

A foam model highlights the differences of the macro- and microrheology of respiratory horse mucus

Gross A, Torge A, Schaefer U, Schneider M, Lehr C, Wagner C (2017)

Journal of the Mechanical Behavior of Biomedical Materials 71: 216-222DOI: 10.1016/j.jmbbm.2017.03.009

Lung alveoli array-on-chip with a bioartificial membrane

Zamprogno P, Achenbach S, Stucki J, Hobi N, Schneider-Daum N, Lehr C, Huwer H, Schmid R, Guenat O (2017)

Toxicology letters 280DOI: 10.1016/j.toxlet.2017.07.974

Diverse Applications of Nanomedicine

Pelaz B, Alexiou C, Alvarez-Puebla R, Alves F, Andrews A, Ashraf S, Balogh L, Ballerini L, Bestetti A, Brendel C, …, Zhou X, Parak W (2017)

ACS Nano 11 (3): 2313-2381DOI: 10.1021/acsnano.6b06040

Modeling the Gram-negative bacterial cell envelope

Gräf F (2017)

Book

Modeling and simulation of the interaction between particles and pulmonary mucus

Ernst M (2017)

Book

Interleukin-10-Loaded Nano- and Microparticles for the Local Treatment of the Intestinal Mucosa and the Deep Lung

Nico Alexander Mell (2017)

Autologous coculture of primary human alveolar epithelial cells and macrophages for evaluating the safety and efficacy of novel inhalation pharmaceuticals

Hittinger M (2017)

Book

Sustained drug delivery for local treatment of joint diseases

Sterner B (2017)

Book

New Horizons in the Development of Novel Needle-Free Immunization Strategies to Increase Vaccination Efficacy

Schulze K, Ebensen T, Riese P, Prochnow B, Lehr C, Guzman C (2016)

Current topics in microbiology and immunologyDOI: 10.1007/82_2016_495

Anti-infectives in Drug Delivery-Overcoming the Gram-Negative Bacterial Cell Envelope

Graef F, Gordon S, Lehr C (2016)

Current topics in microbiology and immunology 398: 475-496DOI: 10.1007/82_2016_491

The bacterial cell envelope as delimiter of anti-infective bioavailability – An in vitro permeation model of the Gram-negative bacterial inner membrane

Graef F, Vukosavljevic B, Michel J, Wirth M, Ries O, De Rossi C, Windbergs M, Rosilio V, Ducho C, Gordon S, Lehr C (2016)

Journal of Controlled Release 243: 214-224DOI: 10.1016/j.jconrel.2016.10.018

Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis

Lerner T, Souza Carvalho-Wodarz C, Repnik U, Russell M, Borel S, Diedrich C, Rohde M, Wainwright H, Collinson L, Wilkinson R, Griffiths G, Gutierrez M (2016)

The Journal of clinical investigation 126 (3): 1093-108DOI: 10.1172/JCI83379

Intracellular Delivery of Poorly Soluble Polyphenols: Elucidating the Interplay of Self-Assembling Nanocarriers and Human Chondrocytes

Kann B, Spengler C, Coradini K, Rigo L, Bennink M, Jacobs K, Offerhaus H, Beck R, Windbergs M (2016)

Analytical chemistry 88 (14): 7014-22DOI: 10.1021/acs.analchem.6b00199

Synthesis of a deuterated probe for the confocal Raman microscopy imaging of squalenoyl nanomedicines

Buchy E, Vukosavljevic B, Windbergs M, Sobot D, Dejean C, Mura S, Couvreur P, Desmaële D (2016)

Beilstein journal of organic chemistry 12: 1127-35DOI: 10.3762/bjoc.12.109

Monitoring Drug Release from Electrospun Fibers Using an In Situ Fiber-Optic System

Seif S, Graef F, Gordon S, Windbergs M (2016)

Dissolution Technologies 23 (2): 6-11DOI: 10.14227/DT230216P6

Three-dimensional hierarchical cultivation of human skin cells on bio-adaptive hybrid fibers

Planz V, Seif S, Atchison J, Vukosavljevic B, Sparenberg L, Kroner E, Windbergs M (2016)

Integrative biology : quantitative biosciences from nano to macro 8 (7): 775-84DOI: 10.1039/c6ib00080k

Novel insights into controlled drug release from coated pellets by confocal Raman microscopy

Vukosavljevic B, Kinder L, Siepmann J, Muschert S, Windbergs M (2016)

J. Raman Spectrosc. 47 (7): 757-762DOI: 10.1002/jrs.4896

Non-invasive insight into the release mechanisms of a poorly soluble drug from amorphous solid dispersions by confocal Raman microscopy

Puncochová K, Vukosavljevic B, Hanuš J, Beránek J, Windbergs M, Štepánek F (2016)

European Journal of Pharmaceutics and Biopharmaceutics 101: 119-25DOI: 10.1016/j.ejpb.2016.02.001

Surface-modified yeast cells: A novel eukaryotic carrier for oral application

Kenngott E, Kiefer R, Schneider-Daum N, Hamann A, Schneider M, Schmitt M, Breinig F (2016)

Journal of controlled release : official journal of the Controlled Release Society 224: 1-7DOI: 10.1016/j.jconrel.2015.12.054

In vitro models for evaluating safety and efficacy of novel technologies for skin drug delivery

Planz V, Lehr C, Windbergs M (2016)

Journal of Controlled Release 242: 89-104DOI: 10.1016/j.jconrel.2016.09.002

Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities

Mostaghaci B, Loretz B, Lehr C (2016)

Current Pharmaceutical Design 22 (11): 1529-33

Preparation of nanosized coacervates of positive and negative starch derivatives intended for pulmonary delivery of proteins

Barthold S, Kletting S, Taffner J, De Souza Carvalho-Wodarz C, Lepeltier E, Loretz B, Lehr C (2016)

Journal of Materials Chemistry B 4 (13): 2377-2386DOI: 10.1039/c6tb00178e

Different macro- and micro-rheological properties of native porcine respiratory and intestinal mucus

Bokkasam H, Ernst M, Guenther M, Wagner C, Schaefer U, Lehr C (2016)

International journal of pharmaceutics 510 (1): 164-167DOI: 10.1016/j.ijpharm.2016.06.035

Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier

Kuehn A, Kletting S, Souza Carvalho-Wodarz C, Repnik U, Griffiths G, Fischer U, Meese E, Huwer H, Wirth D, May T, Schneider-Daum N, Lehr C (2016)

ALTEX 33 (3): 251-60DOI: 10.14573/altex.1511131

Influence of agglomeration and specific lung lining lipid/protein interaction on short-term inhalation toxicity

Wohlleben W, Driessen M, Raesch S, Schaefer U, Schulze C, Vacano B, Vennemann A, Wiemann M, Ruge C, Platsch H, …, Lehr C, Haase A (2016)

Nanotoxicology 10 (7): 970-980DOI: 10.3109/17435390.2016.1155671

Nanocarriers for optimizing the balance between interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverse effects

Mathes C, Melero A, Conrad P, Vogt T, Rigo L, Selzer D, Prado W, De Rossi C, Garrigues T, Hansen S, …, Lehr C, Schaefer U (2016)

Journal of Controlled Release 223: 207-214DOI: 10.1016/j.jconrel.2015.12.010

Self-Assembly and Shape Control of Hybrid Nanocarriers Based on Calcium Carbonate and Carbon Nanodots

Lauth V, Loretz B, Lehr C, Maas M, Rezwan K (2016)

Chemistry of Materials 28 (11): 3796-3803DOI: 10.1021/acs.chemmater.6b00769

Design of Polyamine-Grafted Starches for Nucleotide Analogue Delivery: In Vitro Evaluation of the Anticancer Activity

Kanber E, Yamada H, Loretz B, Lepeltier E, Lehr C (2016)

Bioconjugate chemistryDOI: 10.1021/acs.bioconjchem.6b00396

Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity

Rietscher R, Schröder M, Janke J, Czaplewska J, Gottschaldt M, Scherließ R, Hanefeld A, Schubert U, Schneider M, Knolle P, Lehr C (2016)

European Journal of Pharmaceutics and Biopharmaceutics 102: 20-31DOI: 10.1016/j.ejpb.2016.02.014

Tight junctions form a barrier in porcine hair follicles

Mathes C, Brandner J, Laue M, Raesch S, Hansen S, Failla A, Vidal S, Moll I, Schaefer U, Lehr C (2016)

European Journal of Cell Biology 95 (2): 89-99DOI: 10.1016/j.ejcb.2015.12.001

The effect of polymer size and charge of molecules on permeation through synovial membrane and accumulation in hyaline articular cartilage

Sterner B, Harms M, Wöll S, Weigandt M, Windbergs M, Lehr C (2016)

European Journal of Pharmaceutics and Biopharmaceutics 101: 126-136DOI: 10.1016/j.ejpb.2016.02.004

Sustained-release liquisolid compact tablets containing artemether-lumefantrine as alternate-day regimen for malaria treatment to improve patient compliance

Nnamani P, Ugwu A, Ibezim E, Kenechukwu F, Akpa P, Ogbonna J, Obitte N, Odo A, Windbergs M, Lehr C, Attama A (2016)

International Journal of Nanomedicine 11: 6365-6378DOI: 10.2147/IJN.S92755

Autologous co-culture of primary human alveolar macrophages and epithelial cells for investigating aerosol medicines. Part I: Model Characterisation

Hittinger M, Janke J, Huwer H, Scherließ R, Schneider-Daum N, Lehr C (2016)

ATLA Alternatives to Laboratory Animals 44 (4): 337-347

Nanoparticle-Based Mucosal Vaccines Targeting Tumor-Associated Antigens to Human Dendritic Cells

Brito Baleeiro R, Schweinlin M, Rietscher R, Diedrich A, Czaplewska J, Metzger M, Michael Lehr C, Scherließ R, Hanefeld A, Gottschaldt M, Walden P (2016)

j biomed nanotechnol 12 (7): 1527-1543DOI: 10.1166/jbn.2016.2267

Budesonide Loaded PLGA Nanoparticles for Targeting the Inflamed Intestinal Mucosa--Pharmaceutical Characterization and Fluorescence Imaging

Ali H, Weigmann B, Collnot E, Khan S, Windbergs M, Lehr C (2016)

Pharmaceutical research 33 (5): 1085-92DOI: 10.1007/s11095-015-1852-6

Impact of PEG and PEG-b-PAGE modified PLGA on nanoparticle formation, protein loading and release

Rietscher R, Czaplewska J, Majdanski T, Gottschaldt M, Schubert U, Schneider M, Lehr C (2016)

International journal of pharmaceutics 500 (1-2): 187-195DOI: 10.1016/j.ijpharm.2016.01.021

Dual flow bioreactor with ultrathin microporous TEER sensing membrane for evaluation of nanoparticle toxicity

Sbrana T, Ucciferri N, Favrè M, Ahmed S, Collnot E, Lehr C, Ahluwalia A, Liley M (2016)

Sensors and Actuators, B: Chemical 223: 440-446DOI: 10.1016/j.snb.2015.09.078

Size-Limited Penetration of Nanoparticles into Porcine Respiratory Mucus after Aerosol Deposition

Murgia X, Pawelzyk P, Schaefer U, Wagner C, Willenbacher N, Lehr C (2016)

Biomacromolecules 17 (4): 1536-1542DOI: 10.1021/acs.biomac.6b00164

Autologous co-culture of primary human alveolar macrophages and epithelial cells for investigating aerosol medicines. Part II: evaluation of IL-10-loaded microparticles for the treatment of lung inflammation

Hittinger M, Mell N, Huwer H, Loretz B, Schneider-Daum N, Lehr C (2016)

Alternatives to laboratory animals : ATLA 44 (4): 349-360

Invasin-functionalized liposome nanocarriers improve the intracellular delivery of anti-infective drugs

Menina S, Labouta H, Geyer R, Krause T, Gordon S, Dersch P, Lehr C (2016)

RSC Advances 6 (47): 41622-41629DOI: 10.1039/c6ra02988d

A 3D co-culture of three human cell lines to model the inflamed intestinal mucosa for safety testing of nanomaterials

Susewind J, Souza Carvalho-Wodarz C, Repnik U, Collnot E, Schneider-Daum N, Griffiths G, Lehr C (2016)

Nanotoxicology 10 (1): 53-62DOI: 10.3109/17435390.2015.1008065

IL-17A-mediated expression of epithelial IL-17C promotes inflammation during acute Pseudomonas aeruginosa pneumonia

Wolf L, Sapich S, Honecker A, Jungnickel C, Seiler F, Bischoff M, Wonnenberg B, Herr C, Schneider-Daum N, Lehr C, Bals R, Beisswenger C (2016)

American Journal of Physiology - Lung Cellular and Molecular Physiology 311 (5): 1015-DOI: 10.1152/ajplung.00158.2016

miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity

Serr I, Furst R, Ott V, Scherm M, Nikolaev A, Gokmen F, Kalin S, Zillmer S, Bunk M, Weigmann B, …, Ziegler A, Daniel C (2016)

Proceedings of the National Academy of Sciences of the United States of America 113 (43): 6659-DOI: 10.1073/pnas.1606646113

A new cell line-based coculture model of the human air-blood barrier to evaluate the interaction with aerosolized drug carriers

Kletting S (2016)

Book

Mathematical characterization of skin absorption

Selzer D (2016)

Book

Drug delivery to the hair follicle

Mathes C (2016)

Book

Label-free analysis of drug delivery systems and cellular interaction studies using confocal Raman microscopy

Kann B (2016)

Book

The nanoparticle corona in the deep lung

Räsch S (2016)

Book

Tunable nanoparticles for the local delivery of protein drugs for improved vaccination

Rietscher R (2016)

Book

Immortalization of human alveolar epithelial cells

Kühn A (2016)

Book

Confocal Raman microscopy in skin drug delivery research

Franzen L (2016)

Book

Overview of Inhaled Nanopharmaceuticals

Barthold S, Kunschke N, Murgia X, Loretz B, Carvalho Wodarz C, Lehr C (2015)

Book

Applications of Raman spectroscopy in skin research--From skin physiology and diagnosis up to risk assessment and dermal drug delivery

Franzen L, Windbergs M (2015)

Advanced Drug Delivery Reviews 89: 91-104DOI: 10.1016/j.addr.2015.04.002

Quantitative detection of caffeine in human skin by confocal Raman spectroscopy--A systematic in vitro validation study

Franzen L, Anderski J, Windbergs M (2015)

European Journal of Pharmaceutics and Biopharmaceutics 95 (Pt A): 110-6DOI: 10.1016/j.ejpb.2015.03.026

Novel in vitro approaches for the simulation and analysis of human skin wounds

Planz V, Franzen L, Windbergs M (2015)

Skin Pharmacology and Physiology 28 (2): 91-6DOI: 10.1159/000364810

Raman microscopy for cellular investigations--From single cell imaging to drug carrier uptake visualization

Kann B, Offerhaus H, Windbergs M, Otto C (2015)

Advanced Drug Delivery Reviews 89: 71-90DOI: 10.1016/j.addr.2015.02.006

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

Lefebvre D, Venema K, Gombau L, Valerio L, Raju J, Bondy G, Bouwmeester H, Singh R, Clippinger A, Collnot E, Mehta R, Stone V (2015)

Nanotoxicology 9 (4): 523-42DOI: 10.3109/17435390.2014.948091

Skin penetration behavior of lipid-core nanocapsules for simultaneous delivery of resveratrol and curcumin

Friedrich R, Kann B, Coradini K, Offerhaus H, Beck R, Windbergs M (2015)

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 78: 204-13DOI: 10.1016/j.ejps.2015.07.018

Preface: Pharmaceutical applications of Raman spectroscopy--From diagnosis to therapeutics

Popp J, Windbergs M (2015)

Advanced Drug Delivery Reviews 89: 1-2DOI: 10.1016/j.addr.2015.07.008

pH-triggered drug release from biodegradable microwells for oral drug delivery

Nielsen L, Nagstrup J, Gordon S, Keller S, Østergaard J, Rades T, Müllertz A, Boisen A (2015)

Biomedical microdevices 17 (3)DOI: 10.1007/s10544-015-9958-5

Not just for tumor targeting: Unmet medical needs and opportunities for nanomedicine

Lepeltier E, Nuhn L, Lehr C, Zentel R (2015)

Nanomedicine 10 (20): 3147-3166DOI: 10.2217/nnm.15.132

Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models

Hittinger M, Juntke J, Kletting S, Schneider-Daum N, de Souza Carvalho C, Lehr C (2015)

Advanced Drug Delivery Reviews 85: 44-56DOI: 10.1016/j.addr.2014.10.011

Efficient nanoparticle-mediated needle-free transcutaneous vaccination via hair follicles requires adjuvantation

Mittal A, Schulze K, Ebensen T, Weißmann S, Hansen S, Lehr C, Guzmán C (2015)

Nanomedicine: Nanotechnology, Biology, and Medicine 11 (1): 147-154DOI: 10.1016/j.nano.2014.08.009

Spatial separation of the processing and MHC class I loading compartments for cross-presentation of the tumor-associated antigen HER2/neu by human dendritic cells

Baleeiro R, Rietscher R, Diedrich A, Czaplewska J, Lehr C, Scherließ R, Hanefeld A, Gottschaldt M, Walden P (2015)

Oncoimmunology 4 (11)DOI: 10.1080/2162402X.2015.1047585

P-glycoprotein interactions of novel psychoactive substances - stimulation of ATP consumption and transport across Caco-2 monolayers

Meyer M, Wagmann L, Schneider-Daum N, Loretz B, Souza Carvalho C, Lehr C, Maurer H (2015)

Biochemical pharmacology 94 (3): 220-6DOI: 10.1016/j.bcp.2015.01.008

Expression and function of the epithelial sodium channel δ-subunit in human respiratory epithelial cells in vitro

Schwagerus E, Sladek S, Buckley S, Armas-Capote N, La Rosa D, Harvey B, Fischer H, Illek B, Huwer H, Schneider-Daum N, Lehr C, Ehrhardt C (2015)

Pflugers Archiv European Journal of Physiology 467 (11): 2257-2273DOI: 10.1007/s00424-015-1693-5

Enhanced uptake and siRNA-mediated knockdown of a biologically relevant gene using cyclodextrin polyrotaxane

Dandekar P, Jain R, Keil M, Loretz B, Koch M, Wenz G, Lehr C (2015)

Journal of Materials Chemistry B 3 (13): 2590-2598DOI: 10.1039/c4tb01821d

A design of experiment study of nanoprecipitation and nano spray drying as processes to prepare plga nano-and microparticles with defined sizes and size distributions

Draheim C, De Crécy F, Hansen S, Collnot E, Lehr C (2015)

Pharmaceutical research 32 (8): 2609-2624DOI: 10.1007/s11095-015-1647-9

In vitro–in vivo correlation

Barakat A, Krämer J, Souza Carvalho C, Lehr C (2015)

Dissolution Technologies 22 (2): 19-22DOI: 10.14227/DT220215P19

Transfection system of amino-functionalized calcium phosphate nanoparticles: in vitro efficacy, biodegradability, and immunogenicity study

Mostaghaci B, Susewind J, Kickelbick G, Lehr C, Loretz B (2015)

ACS applied materials & interfaces 7 (9): 5124-33DOI: 10.1021/am507193a

Macrophage uptake of cylindrical microparticles investigated with correlative microscopy

Tscheka C, Hittinger M, Lehr C, Schneider-Daum N, Schneider M (2015)

European Journal of Pharmaceutics and Biopharmaceutics 95: 151-155DOI: 10.1016/j.ejpb.2015.03.010

Bacteriomimetic invasin-functionalized nanocarriers for intracellular delivery

Labouta H, Menina S, Kochut A, Gordon S, Geyer R, Dersch P, Lehr C (2015)

Journal of Controlled Release 220: 414-424DOI: 10.1016/j.jconrel.2015.10.052

Mono- and Cocultures of Bronchial and Alveolar Epithelial Cells Respond Differently to Proinflammatory Stimuli and Their Modulation by Salbutamol and Budesonide

Haghi M, Hittinger M, Zeng Q, Oliver B, Traini D, Young P, Huwer H, Schneider-Daum N, Lehr C (2015)

Molecular pharmaceutics 12 (8): 2625-32DOI: 10.1021/acs.molpharmaceut.5b00124

Proteomic and Lipidomic Analysis of Nanoparticle Corona upon Contact with Lung Surfactant Reveals Differences in Protein, but Not Lipid Composition

Raesch S, Tenzer S, Storck W, Rurainski A, Selzer D, Ruge C, Perez-Gil J, Schaefer U, Lehr C (2015)

ACS Nano 9 (12): 11872-11885DOI: 10.1021/acsnano.5b04215

Inhalable Clarithromycin Microparticles for Treatment of Respiratory Infections

Dimer F, De Souza Carvalho-Wodarz C, Haupenthal J, Hartmann R, Lehr C (2015)

Pharmaceutical research 32 (12): 3850-3861DOI: 10.1007/s11095-015-1745-8

Cyclodextrin-based star polymers as a versatile platform for nanochemotherapeutics: Enhanced entrapment and uptake of idarubicin

Nafee N, Hirosue M, Loretz B, Wenz G, Lehr C (2015)

Colloids and surfaces. B, Biointerfaces 129: 30-8DOI: 10.1016/j.colsurfb.2015.03.014

Semi-automated nanoprecipitation-system - An option for operator independent, scalable and size adjustable nanoparticle synthesis

Rietscher R, Thum C, Lehr C, Schneider M (2015)

Pharmaceutical research 32 (6): 1859-1863DOI: 10.1007/s11095-014-1612-z

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology

Gordon S, Daneshian M, Bouwstra J, Caloni F, Constant S, Davies D, Dandekar G, Guzman C, Fabian E, Haltner E, …, Walles H, Lehr C (2015)

ALTEX 32 (4): 327-378DOI: 10.14573/altex.1510051

A strategy for in-silico prediction of skin absorption in man

Selzer D, Neumann D, Neumann H, Kostka K, Lehr C, Schaefer U (2015)

European Journal of Pharmaceutics and Biopharmaceutics 95: 68-76DOI: 10.1016/j.ejpb.2015.05.002

Dimethylaminoethyl methacrylate copolymer-siRNA nanoparticles for silencing a therapeutically relevant gene in macrophages

Jain R, Dandekar P, Loretz B, Koch M, Lehr C (2015)

MedChemComm 6 (4): 691-701DOI: 10.1039/c4md00490f

Focused Ultrasound as a Scalable and Contact-Free Method to Manufacture Protein-Loaded PLGA Nanoparticles

Schiller S, Hanefeld A, Schneider M, Lehr C (2015)

Pharmaceutical research 32 (9): 2995-3006DOI: 10.1007/s11095-015-1681-7

Solid Phase Extraction as an Innovative Separation Method for Measuring Free and Entrapped Drug in Lipid Nanoparticles

Guillot A, Couffin A, Sejean X, Navarro F, Limberger M, Lehr C (2015)

Pharmaceutical research 32 (12): 3999-4009DOI: 10.1007/s11095-015-1761-8

Miniature in vitro dissolution testing of powders for inhalation

May S, Kind S, Jensen B, Wolkenhauer M, Schneider M, Lehr C (2015)

Dissolution Technologies 22 (3): 40-51DOI: 10.14227/DT220315P40

Squalenoylation of Chitosan: A Platform for Drug Delivery?

Lepeltier E, Loretz B, Desmaele D, Zapp J, Herrmann J, Couvreur P, Lehr C (2015)

Biomacromolecules 16 (9): 2930-9DOI: 10.1021/acs.biomac.5b00840

Inverse micellar sugar glass (IMSG) nanoparticles for transfollicular vaccination

Mittal A, Schulze K, Ebensen T, Weissmann S, Hansen S, Guzmán C, Lehr C (2015)

Journal of Controlled Release 206: 140-152DOI: 10.1016/j.jconrel.2015.03.017

The buccal mucosa as a route for TiO2 nanoparticle uptake

Teubl B, Leitinger G, Schneider M, Lehr C, Fröhlich E, Zimmer A, Roblegg E (2015)

Nanotoxicology 9 (2): 253-261DOI: 10.3109/17435390.2014.921343

In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency

Mahiny A, Dewerth A, Mays L, Alkhaled M, Mothes B, Malaeksefat E, Loretz B, Rottenberger J, Brosch D, Reautschnig P, …, Lehr C, Kormann M (2015)

Nature biotechnology 33 (6): 584-6DOI: 10.1038/nbt.3241

Organic cation transporter function in different in vitro models of human lung epithelium

Salomon J, Gausterer J, Yahara T, Hosoya K, Huwer H, Hittinger M, Schneider-Daum N, Lehr C, Ehrhardt C (2015)

European Journal of Pharmaceutical Sciences 80: 82-88DOI: 10.1016/j.ejps.2015.08.007

Advanced formulations of cyclosporine A and budesonide for the therapy of inflammatory bowel disease

Draheim C (2015)

Book

Synthesis and Characterization of Novel Amino-modified Calcium Phosphate Nanoparticles Used for Gene Delivery Applications

Mostaghaci B (2015)

Development and characterization of nanoparticular systems for an innovating therapeutic concept for targeting Inflammatory Bowel Diseases using the Quality-by-Design approach

Guillot A (2015)

Overcoming the pulmonary barrier: New insights to improve the efficiency of inhaled therapeutics

Murgia X, de Souza Carvalho C, Lehr C (2014)

European Journal of Nanomedicine 6 (3): 157-169DOI: 10.1515/ejnm-2014-0019

Carrier interactions with the biological barriers of the lung: Advanced in vitro models and challenges for pulmonary drug delivery

de Souza Carvalho C, Daum N, Lehr C (2014)

Advanced Drug Delivery Reviews 75: 129-140DOI: 10.1016/j.addr.2014.05.014

Transfollicular delivery takes root

Hansen S, Lehr C (2014)

Expert Review of Vaccines 13 (1): 5-7DOI: 10.1586/14760584.2014.862500

Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application

Nnamani P, Hansen S, Windbergs M, Lehr C (2014)

International journal of pharmaceutics 477 (1-2): 208-217DOI: 10.1016/j.ijpharm.2014.10.004

Budesonide loaded nanoparticles with pH-sensitive coating for improved mucosal targeting in mouse models of inflammatory bowel diseases

Ali H, Weigmann B, Neurath M, Collnot E, Windbergs M, Lehr C (2014)

Journal of Controlled Release 183 (1): 167-177DOI: 10.1016/j.jconrel.2014.03.039

Dissolution testing of powders for inhalation

May S, Jensen B, Weiler C, Wolkenhauer M, Schneider M, Lehr C (2014)

Pharmaceutical research 31 (11): 3211-3224DOI: 10.1007/s11095-014-1413-4

Statistical comparison of dissolution profiles to predict the bioequivalence of extended release formulations

Gomez-Mantilla J, Schaefer U, Casabo V, Lehr T, Lehr C (2014)

AAPS Journal 16 (4): 791-801DOI: 10.1208/s12248-014-9615-6

Antibiotic-free nanotherapeutics: Ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors

Nafee N, Husari A, Maurer C, Lu C, De Rossi C, Steinbach A, Hartmann R, Lehr C, Schneider M (2014)

Journal of Controlled Release 192: 131-140DOI: 10.1016/j.jconrel.2014.06.055

The cell line NCl-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier

Salomon J, Muchitsch V, Gausterer J, Schwagerus E, Huwer H, Daum N, Lehr C, Ehrhardt C (2014)

Molecular pharmaceutics 11 (3): 995-1006DOI: 10.1021/mp4006535

In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response

Ucciferri N, Collnot E, Gaiser B, Tirella A, Stone V, Domenici C, Lehr C, Ahluwalia A (2014)

Nanotoxicology 8 (6): 697-708DOI: 10.3109/17435390.2013.831500

Characterization and evaluation of a modified PVPA barrier in comparison to Caco-2 cell monolayers for combined dissolution and permeation testing

Gantzsch S, Kann B, Ofer-Glaessgen M, Loos P, Berchtold H, Balbach S, Eichinger T, Lehr C, Schaefer U, Windbergs M (2014)

Journal of Controlled Release 175 (1): 79-86DOI: 10.1016/j.jconrel.2013.12.009

Quantification of nanoparticle uptake into hair follicles in pig ear and human forearm

Raber A, Mittal A, Schäfer J, Bakowsky U, Reichrath J, Vogt T, Schaefer U, Hansen S, Lehr C (2014)

Journal of Controlled Release 179 (1): 25-32DOI: 10.1016/j.jconrel.2014.01.018

Non-invasive determination of cellular oxygen consumption as novel cytotoxicity assay for nanomaterials

Neumeyer A, Bukowski M, Veith M, Lehr C, Daum N (2014)

Nanotoxicology 8 (1): 50-60DOI: 10.3109/17435390.2012.747639

Nanoencapsulation in lipid-core nanocapsules controls mometasone furoate skin permeability rate and its penetration to the deeper skin layers

Melero A, Ferreira Ourique A, Stanisçuaski Guterres S, Raffin Pohlmann A, Lehr C, Ruver Beck R, Schaefer U (2014)

Skin Pharmacology and Physiology 27 (4): 217-228DOI: 10.1159/000354921

Design of starch-graft-PEI polymers: an effective and biodegradable gene delivery platform

Yamada H, Loretz B, Lehr C (2014)

Biomacromolecules 15 (5): 1753-61DOI: 10.1021/bm500128k

Crystal suspensions of poorly soluble peptides for intra-articular application: A novel approach for biorelevant assessment of their in vitro release

Sterner B, Harms M, Weigandt M, Windbergs M, Lehr C (2014)

International journal of pharmaceutics 461 (1-2): 46-53DOI: 10.1016/j.ijpharm.2013.11.031

Polyester-idarubicin nanoparticles and a polymer-photosensitizer complex as potential drug formulations for cell-mediated drug delivery

Blaudszun A, Lian Q, Schnabel M, Loretz B, Steinfeld U, Lee H, Wenz G, Lehr C, Schneider M, Philippi A (2014)

International journal of pharmaceutics 474 (1-2): 70-9DOI: 10.1016/j.ijpharm.2014.07.048

Exploring the follicular route for transcutaneous vaccination using nanoparticles

Mittal A (2014)

Statistical approaches to perform dissolution profile comparisons

Gómez Mantilla J (2014)

Book

Starch based cationic polymers for gene delivery

Yamada H (2014)

Book

Endothelial and epithelial differentiation potential of human adult stem cells PSC and MSC and the relation of ZO-1 isoform ratio to epithelial differentiation in Caco-2

Meier K (2014)

Book

Nanomedicines for the treatment of inflammatory bowel diseases

Ali H, Collnot E, Windbergs M, Lehr C (2013)

European Journal of Nanomedicine 5 (1)DOI: 10.1515/ejnm-2013-0004

From the structure of the skin barrier and dermal formulations to in vitro transport models for skin absorption

Windbergs M, Hansen S, Schroeter A, Schaefer U, Lehr C, Bouwstra J (2013)

Skin Pharmacology and Physiology 26 (4-6): 317-330DOI: 10.1159/000351936

Particle based vaccine formulations for transcutaneous immunization

Mittal A, Raber A, Lehr C, Hansen S (2013)

Human Vaccines and Immunotherapeutics 9 (9): 1950-1955DOI: 10.4161/hv.25217

Crossing biological barriers for advanced drug delivery

Schneider M, Windbergs M, Daum N, Loretz B, Collnot E, Hansen S, Schaefer U, Lehr C (2013)

European Journal of Pharmaceutics and Biopharmaceutics 84 (2): 239-241DOI: 10.1016/j.ejpb.2013.03.009

Mucus as a barrier to lipophilic drugs

Sigurdsson H, Kirch J, Lehr C (2013)

International journal of pharmaceutics 453 (1): 56-64DOI: 10.1016/j.ijpharm.2013.05.040

Pulmonary drug delivery: From generating aerosols to overcoming biological barriers-therapeutic possibilities and technological challenges

Ruge C, Kirch J, Lehr C (2013)

The Lancet Respiratory Medicine 1 (5): 402-413DOI: 10.1016/S2213-2600(13)70072-9

Modeling the human skin barrier-Towards a better understanding of dermal absorption

Hansen S, Lehr C, Schaefer U (2013)

Advanced Drug Delivery Reviews 65 (2): 149-151DOI: 10.1016/j.addr.2012.12.002

Improved input parameters for diffusion models of skin absorption

Hansen S, Lehr C, Schaefer U (2013)

Advanced Drug Delivery Reviews 65 (2): 251-264DOI: 10.1016/j.addr.2012.04.011

One-step synthesis of nanosized and stable amino-functionalized calcium phosphate particles for DNA transfection

Mostaghaci B, Loretz B, Haberkorn R, Kickelbick G, Lehr C (2013)

Chemistry of Materials 25 (18): 3667-3674DOI: 10.1021/cm401886u

Nanoparticle geometry and surface orientation influence mode of cellular uptake

Herd H, Daum N, Jones A, Huwer H, Ghandehari H, Lehr C (2013)

ACS Nano 7 (3): 1961-1973DOI: 10.1021/nn304439f

Pulmonary surfactant is indispensable in order to simulate the in vivo situation

Schleh C, Kreyling W, Lehr C (2013)

Particle and Fibre Toxicology 10 (1)DOI: 10.1186/1743-8977-10-6

Finite dose skin mass balance including the lateral part: Comparison between experiment, pharmacokinetic modeling and diffusion models

Selzer D, Hahn T, Naegel A, Heisig M, Kostka K, Lehr C, Neumann D, Schaefer U, Wittum G (2013)

Journal of Controlled Release 165 (2): 119-128DOI: 10.1016/j.jconrel.2012.10.009

Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa - A first in vivo study in human patients

Schmidt C, Lautenschlaeger C, Collnot E, Schumann M, Bojarski C, Schulzke J, Lehr C, Stallmach A (2013)

Journal of Controlled Release 165 (2): 139-145DOI: 10.1016/j.jconrel.2012.10.019

Non-invasive delivery of nanoparticles to hair follicles: A perspective for transcutaneous immunization

Mittal A, Raber A, Schaefer U, Weissmann S, Ebensen T, Schulze K, Guzmán C, Lehr C, Hansen S (2013)

Vaccine 31 (34): 3442-3451DOI: 10.1016/j.vaccine.2012.12.048

PEG-functionalized microparticles selectively target inflamed mucosa in inflammatory bowel disease

Lautenschläger C, Schmidt C, Lehr C, Fischer D, Stallmach A (2013)

European Journal of Pharmaceutics and Biopharmaceutics 85 (3 PART A): 578-586DOI: 10.1016/j.ejpb.2013.09.016

In situ drug release monitoring with a fiber-optic system: Overcoming matrix interferences using derivative spectrophotometry

Guillot A, Limberge M, Krämer J, Lehr C (2013)

Dissolution Technologies 20 (2): 15-19

Biopharmaceutical in vitro characterization of CPZEN-45, a drug candidate for inhalation therapy of tuberculosis

Salomon J, Galeron P, Schulte N, Morow P, Severynse-Stevens D, Huwer H, Daum N, Lehr C, Hickey A, Ehrhardt C (2013)

Therapeutic delivery 4 (8): 915-923DOI: 10.4155/tde.13.62

Permutation Test (PT) and Tolerated Difference Test (TDT)

Gómez-Mantilla J, Casabó V, Schaefer U, Lehr C (2013)

International journal of pharmaceutics 441 (1-2): 458-467DOI: 10.1016/j.ijpharm.2012.11.008

Implementation of a lipid-coated membrane in a combined dissolution and permeation system and comparison to Caco-2 cell monolayers

Gantzsch S (2013)

Book

Dissolution testing of powders for inhalation

May S (2013)

Book

Budesonide Loaded pH-sensitive PLGA Nanoparticles for the Treatment of Inflammatory Bowel Disease

Ali H (2013)

Novel cell based in vitro models to study nanoparticle interaction with the inflamed intestinal mucosa

Leonard F (2013)

Book

Isolation, cultivation, and application of human alveolar epithelial cells

Daum N, Kuehn A, Hein S, Schaefer U, Huwer H, Lehr C (2012)

Methods in molecular biology (Clifton, N.J.) 806: 31-42DOI: 10.1007/978-1-61779-367-7_3

Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus

Kirch J, Schneider A, Abou B, Hopf A, Schaefer U, Schneider M, Schall C, Wagner C, Lehr C (2012)

Proceedings of the National Academy of Sciences of the United States of America 109 (45): 18355-18360DOI: 10.1073/pnas.1214066109

Nano- and microparticulate drug carriers for targeting of the inflamed intestinal mucosa

Collnot E, Ali H, Lehr C (2012)

Journal of Controlled Release 161 (2): 235-246DOI: 10.1016/j.jconrel.2012.01.028

Nanoparticles for transcutaneous vaccination

Hansen S, Lehr C (2012)

Microbial Biotechnology 5 (2): 156-167DOI: 10.1111/j.1751-7915.2011.00284.x

Dissolution techniques for in vitro testing of dry powders for inhalation

May S, Jensen B, Wolkenhauer M, Schneider M, Lehr C (2012)

Pharmaceutical research 29 (8): 2157-2166DOI: 10.1007/s11095-012-0744-2

Characterization and evaluation of β-glucan formulations as injectable implants for protein and peptide delivery

Jacobs S, Bunt C, Wu Z, Lehr C, Rupenthal I (2012)

Drug Development and Industrial Pharmacy 38 (11): 1337-1343DOI: 10.3109/03639045.2011.650646

Atomic force microscopy and analytical ultracentrifugation for probing nanomaterial protein interactions

Schaefer J, Schulze C, Marxer E, Schaefer U, Wohlleben W, Bakowsky U, Lehr C (2012)

ACS Nano 6 (6): 4603-4614DOI: 10.1021/nn202657q

Treatment of lung cancer via telomerase inhibition

Nafee N, Schneider M, Friebel K, Dong M, Schaefer U, Mürdter T, Lehr C (2012)

European Journal of Pharmaceutics and Biopharmaceutics 80 (3): 478-489DOI: 10.1016/j.ejpb.2011.11.019

Cellular delivery of polynucleotides by cationic cyclodextrin polyrotaxanes

Dandekar P, Jain R, Keil M, Loretz B, Muijs L, Schneider M, Auerbach D, Jung G, Lehr C, Wenz G (2012)

Journal of controlled release : official journal of the Controlled Release Society 164 (3): 387-93DOI: 10.1016/j.jconrel.2012.06.040

A hydrophobic starch polymer for nanoparticle-mediated delivery of docetaxel

Dandekar P, Jain R, Stauner T, Loretz B, Koch M, Wenz G, Lehr C (2012)

Macromolecular Bioscience 12 (2): 184-94DOI: 10.1002/mabi.201100244

Process optimization and biocompatibility of cell carriers suitable for automated magnetic manipulation

Krejci I, Piana C, Howitz S, Wegener T, Fiedler S, Zwanzig M, Schmitt D, Daum N, Meier K, Lehr C, …, Wirth M, Gabor F (2012)

Acta Biomaterialia 8 (3): 1239-1247DOI: 10.1016/j.actbio.2011.08.031

Influence of the application area on finite dose permeation in relation to drug type applied

Hahn T, Selzer D, Neumann D, Kostka K, Lehr C, Schaefer U (2012)

Experimental Dermatology 21 (3): 233-235DOI: 10.1111/j.1600-0625.2011.01424.x

The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles

Ruge C, Schaefer U, Herrmann J, Kirch J, Cañadas O, Echaide M, Pérez-Gil J, Casals C, Müller R, Lehr C (2012)

PLoS ONE 7 (7)DOI: 10.1371/journal.pone.0040775

Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo

Linn M, Collnot E, Djuric D, Hempel K, Fabian E, Kolter K, Lehr C (2012)

European Journal of Pharmaceutical Sciences 45 (3): 336-343DOI: 10.1016/j.ejps.2011.11.025

Screening of budesonide nanoformulations for treatment of inflammatory bowel disease in an inflamed 3D cell-culture model

Leonard F, Ali H, Collnot E, Crielaard B, Lammers T, Storm G, Lehr C (2012)

ALTEX 29 (3): 275-285

Pulmonary delivery and tissue distribution of aerosolized antisense 2'-O-Methyl RNA containing nanoplexes in the isolated perfused and ventilated rat lung

Dong M, Murdter T, Philippi C, Loretz B, Schaefer U, Lehr C, Schwab M, Ammon-Treiber S (2012)

European Journal of Pharmaceutics and Biopharmaceutics 81 (3): 478-85DOI: 10.1016/j.ejpb.2012.04.022

Mucociliary clearance of micro- and nanoparticles is independent of size, shape and charge-an ex vivo and in silico approach

Kirch J, Guenther M, Doshi N, Schaefer U, Schneider M, Mitragotri S, Lehr C (2012)

Journal of Controlled Release 159 (1): 128-134DOI: 10.1016/j.jconrel.2011.12.015

Evaluation of finite dose skin absorption experiments with respect to experimental setup and mathematical modelling

Hahn T (2012)

Book

Bio-nano interactions in the peripheral lungs

Ruge C (2012)

Book

The role of fluid dynamics, microstructure and mucociliary clearance in the micro- and macroscopic barrier properties of pulmonary mucus

Kirch J (2012)

Book

In vitro characterization of the novel solubility enhancing excipient Soluplus®

Linn M (2012)

Book

New hope for inflammatory bowel disease

Collnot E, Mell N, Lehr C (2011)

Deutsche Apotheker Zeitung 151 (27): 60-63

Using nanoparticles in the skin? More than just cosmetics!

Hansen S, Lehr C (2011)

Deutsche Apotheker Zeitung 151 (27): 64-67

Towards nanotechnology regulation - Publish the unpublishable

Hankin S, Boraschi D, Duschl A, Lehr C, Lichtenbeld H (2011)

Nano Today 6 (3): 228-231DOI: 10.1016/j.nantod.2011.03.002

Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A

Ruge C, Kirch J, Cañadas O, Schneider M, Perez-Gil J, Schaefer U, Casals C, Lehr C (2011)

Nanomedicine: Nanotechnology, Biology, and Medicine 7 (6): 690-693DOI: 10.1016/j.nano.2011.07.009

A new Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) to evaluate pulmonary drug absorption for metered dose dry powder formulations

Hein S, Bur M, Schaefer U, Lehr C (2011)

European Journal of Pharmaceutics and Biopharmaceutics 77 (1): 132-138DOI: 10.1016/j.ejpb.2010.10.003

Propidium iodide labeling of nanoparticles as a novel tool for the quantification of cellular binding and uptake

Neumeyer A, Bukowski M, Veith M, Lehr C, Daum N (2011)

Nanomedicine: Nanotechnology, Biology, and Medicine 7 (4): 410-419DOI: 10.1016/j.nano.2010.12.007

Interaction of metal oxide nanoparticles with lung surfactant protein A

Schulze C, Schaefer U, Ruge C, Wohlleben W, Lehr C (2011)

European Journal of Pharmaceutics and Biopharmaceutics 77 (3): 376-383DOI: 10.1016/j.ejpb.2010.10.013

Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2'-O-methyl-RNA

Dong M, Philippi C, Loretz B, Nafee N, Schaefer U, Friedel G, Ammon-Treiber S, Griese E, Lehr C, Klotz U, Murdter T (2011)

International journal of pharmaceutics 419 (1-2): 33-42DOI: 10.1016/j.ijpharm.2011.07.009

Improved photostability and reduced skin permeation of tretinoin

Ourique A, Melero A, Silva C, Schaefer U, Pohlmann A, Guterres S, Lehr C, Kostka K, Beck R (2011)

European Journal of Pharmaceutics and Biopharmaceutics 79 (1): 95-101DOI: 10.1016/j.ejpb.2011.03.008

Transport of Metal Oxide Nanoparticles Across Calu-3 Cell Monolayers Modelling the Air-Blood Barrier

Schulze C, Schaefer U, Voetz M, Wohlleben W, Venzago C, Lehr C (2011)

EURO-NanoTox-Letters 3 (1): 1-10DOI: 10.1515/entl-2015-0003

Template-assisted polyelectrolyte encapsulation of nanoparticles into dispersible, hierarchically nanostructured microfibers

Kohler D, Schneider M, Krüger M, Lehr C, Möhwald H, Wang D (2011)

Advanced Materials 23 (11): 1376-1379DOI: 10.1002/adma.201004048

Computational fluid dynamics of nanoparticle disposition in the airways

Kirch J, Guenther M, Schaefer U, Schneider M, Lehr C (2011)

Computing and Visualization in Science 14 (7): 301-308DOI: 10.1007/s00791-012-0184-x

An in vitro triple cell co-culture model with primary cells mimicking the human alveolar epithelial barrier

Lehmann A, Daum N, Bur M, Lehr C, Gehr P, Rothen-Rutishauser B (2011)

European Journal of Pharmaceutics and Biopharmaceutics 77 (3): 398-406DOI: 10.1016/j.ejpb.2010.10.014

Enhanced cellular delivery of idarubicin by surface modification of propyl starch nanoparticles employing pteroic acid conjugated polyvinyl alcohol

Jain R, Dandekar P, Loretz B, Melero A, Stauner T, Wenz G, Koch M, Lehr C (2011)

International journal of pharmaceutics 420 (1): 147-55DOI: 10.1016/j.ijpharm.2011.08.030

Finite dose skin penetration

Naegel A, Hahn T, Schaefer U, Lehr C, Heisig M, Wittum G (2011)

Computing and Visualization in Science 14 (7): 327-339DOI: 10.1007/s00791-012-0186-8

Selective follicular targeting by modification of the particle sizes

Patzelt A, Richter H, Knorr F, Schäfer U, Lehr C, Dähne L, Sterry W, Lademann J (2011)

Journal of Controlled Release 150 (1): 45-48DOI: 10.1016/j.jconrel.2010.11.015

Asymmetric particles for pulmonary drug delivery

Kohler D (2011)

Book

Multilayer coating of gold nanoparticles (AuNP) with drug-polymer complex

Reum N (2011)

Book

New models for telomerase inhibition by antisense 2'-O-methyl-RNA in lung cancer therapy

Dong M (2011)

Book

Pulmonary drug delivery

Henning A, Hein S, Schneider M, Bur M, Lehr C (2010)

Book 197DOI: 10.1007/978-3-642-00477-3_6

Ointment bases and the rate of water loss of the skin

Hahn T, Winkler K, Lehr C, Schäfer U (2010)

Deutsche Apotheker Zeitung 150 (34): 59-62

Telomerase as an emerging target to fight cancer - Opportunities and challenges for nanomedicine

Philippi C, Loretz B, Schaefer U, Lehr C (2010)

Journal of Controlled Release 146 (2): 228-240DOI: 10.1016/j.jconrel.2010.03.025

Preparation of elongated polyelectrolyte particles from particles

Kohler D, Schneider M, Lehr C, Krüger M, Möhwald H, Wang D (2010)

European Cells and Materials 20 (SUPPL.3)

Plant genetic factors for iron homeostasis affect iron bioavailability in Caco-2 cells

Maurer F, Daum N, Schaefer U, Lehr C, Bauer P (2010)

Food Research International 43 (6): 1661-1665DOI: 10.1016/j.foodres.2010.05.008

Influence of particle size and material properties on mucociliary clearance from the airways

Henning A, Schneider M, Nafee N, Muijs L, Rytting E, Wang X, Kissel T, Grafahrend D, Klee D, Lehr C (2010)

Journal of aerosol medicine and pulmonary drug delivery 23 (4): 233-241DOI: 10.1089/jamp.2009.0806

Nanoparticle mediated delivery of 2′-O-methyl-RNA leads to efficient telomerase inhibition and telomere shortening in human lung cancer cells

Beisner J, Dong M, Taetz S, Nafee N, Griese E, Schaefer U, Lehr C, Klotz U, Mürdter T (2010)

Lung Cancer 68 (3): 346-354DOI: 10.1016/j.lungcan.2009.07.010

The Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) in vitro system

Hein S, Bur M, Kolb T, Muellinger B, Schaefer U, Lehr C (2010)

ATLA Alternatives to Laboratory Animals 38 (4): 285-295

A dynamic ratio of the α+ and α- isoforms of the tight junction protein ZO-1 is characteristic of Caco-2 cells and correlates with their degree of differentiation

Ciana A, Meier K, Daum N, Gerbes S, Veith M, Lehr C, Minetti G (2010)

Cell Biology International 34 (6): 669-678DOI: 10.1042/CBI20090067

A three-dimensional coculture of enterocytes, monocytes and dendritic cells to model inflamed intestinal mucosa in vitro

Leonard F, Collnot E, Lehr C (2010)

Molecular pharmaceutics 7 (6): 2103-2119DOI: 10.1021/mp1000795

Differential cell reaction upon Toll-like receptor 4 and 9 activation in human alveolar and lung interstitial macrophages

Hoppstädter J, Diesel B, Zarbock R, Breinig T, Monz D, Koch M, Meyerhans A, Gortner L, Lehr C, Huwer H, Kiemer A (2010)

Respiratory Research 11DOI: 10.1186/1465-9921-11-124

In vitro and in vivo performance of biocompatible negatively-charged salbutamol-loaded nanoparticles

Rytting E, Bur M, Cartier R, Bouyssou T, Wang X, Krüger M, Lehr C, Kissel T (2010)

Journal of Controlled Release 141 (1): 101-107DOI: 10.1016/j.jconrel.2009.08.021

Nanoparticles made from novel starch derivatives for transdermal drug delivery

Santander-Ortega M, Stauner T, Loretz B, Ortega-Vinuesa J, Bastos-Gonzalez D, Wenz G, Schaefer U, Lehr C (2010)

Journal of controlled release : official journal of the Controlled Release Society 141 (1): 85-92DOI: 10.1016/j.jconrel.2009.08.012

Multilayer coating of gold nanoparticles with drug-polymer coadsorbates

Reum N, Fink-Straube C, Klein T, Hartmann R, Lehr C, Schneider M (2010)

Langmuir 26 (22): 16901-16908DOI: 10.1021/la103109b

Wistar rat skin as surrogate for human skin in nortriptyline hydrochloride patch studies

Melero A, Lehr C, Schäfer U, Garrigues T (2010)

International journal of pharmaceutics 384 (1-2): 137-139DOI: 10.1016/j.ijpharm.2009.09.028

Online monitoring of transepithelial electrical resistance (TEER) in an apparatus for combined dissolution and permeation testing

Muendoerfer M, Schaefer U, Koenig P, Walk J, Loos P, Balbach S, Eichinger T, Lehr C (2010)

International journal of pharmaceutics 392 (1-2): 134-140DOI: 10.1016/j.ijpharm.2010.03.046

Vitamin e TPGS P-glycoprotein inhibition mechanism

Collnot E, Baldes C, Schaefer U, Edgar K, Wempe M, Lehr C (2010)

Molecular pharmaceutics 7 (3): 642-651DOI: 10.1021/mp900191s

Drug transport across pulmonary epithelial cell monolayers: effects of particle size, apical liquid volume, and deposition technique

Bur M, Huwer H, Muys L, Lehr C (2010)

Journal of aerosol medicine and pulmonary drug delivery 23 (3): 119-27DOI: 10.1089/jamp.2009.0757

Cellular responses after exposure of lung cell cultures to secondary organic aerosol particles

Gaschen A, Lang D, Kalberer M, Savi M, Geiser T, Gazdhar A, Lehr C, Bur M, Dommen J, Baltensperger U, Geiser M (2010)

Environmental Science and Technology 44 (4): 1424-1430DOI: 10.1021/es902261m

Infrared densitometry

Hahn T, Hansen S, Neumann D, Kostka K, Lehr C, Muys L, Schaefer U (2010)

Skin Pharmacology and Physiology 23 (4): 183-192DOI: 10.1159/000288165

Calorimetric and spectrophotometric investigation of PLGA nanoparticles and their complex with DNA

Khvedelidze M, Mdzinarashvili T, Partskhaladze T, Nafee N, Schaefer U, Lehr C, Schneider M (2010)

Journal of Thermal Analysis and Calorimetry 99 (1): 337-348DOI: 10.1007/s10973-009-0137-x

Combined assessment of drug dissolution and epithelial permeability

Mündörfer M (2010)

Book

Pharmaceutical aerosol deposition device on cell cultures (PADDOCC)

Hein S (2010)

Book

The potential of silica nanoparticles as oral drug carriers

Neumeyer A (2010)

Book

Transport of metal oxide nanoparticles across the human air-blood barrier

Schulze C (2010)

Book

Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS

Collnot E, Baldes C, Wempe M, Kappl R, Hüttermann J, Hyatt J, Edgar K, Schaefer U, Lehr C (2007)

Molecular pharmaceutics 4 (3): 465-474DOI: 10.1021/mp060121r

Preparation and characterization of cationic PLGA nanospheres as DNA carriers

Ravi Kumar M, Bakowsky U, Lehr C (2004)

Biomaterials 25 (10): 1771-1777DOI: 10.1016/j.biomaterials.2003.08.069

Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa

Lamprecht A, Schäfer U, Lehr C (2001)

Pharmaceutical research 18 (6): 788-793DOI: 10.1023/A:1011032328064