Dr. Nicole Schneider-Daum
Über
Nicole Schneider-Daum studierte Lebensmittelchemie an der Universität Kaiserslautern. Nach Forschungsaufenthalten an der Universität von Campinas (Unicamp, Brasilien) und der Universität Murcia (Spanien) she graduated in 2000. Im Anschluss an ihre Promotion am Deutschen Krebsforschungszentrum (DKFZ) in Heidelberg arbeitete sie ab 2004 als Postdoc im Institut für Biopharmazie und Pharmazeutische Technologie (Universität des Saarlandes) an der Interaktion von Nanopartikeln mit biologischen Barrieren.
Seit 2010 ist Nicole Schneider-Daum Wissenschaftlerin in der Abteilung “Drug Delivery” (DDEL) des HIPS und beschäftigt sich mit der Etablierung komplexer, krankheitsrelevanter in vitro Modelle des Respirationstraktes. Solche Modelle dienen nicht nur der Evaluierung neuartiger Antiinfektiva und entsprechender Drug Delivery Systeme, sondern auch der Entwicklung von Alternativen zu Tierversuchen.
Nicole Schneider-Daum ist Sicherheitsbeauftragte und Beauftragte für Biologische Sicherheit der Abteilung „Drug Delivery“ und Mitglied des HZI-Mediatorenteams.
2026
pH-Responsive Isoprenoid-Antitumoral Polymer Conjugates for Superior Drug Loading via Self-Assembly and Endosomal-Targeted Anticancer Activity
Passi C, Neu T, Schneider-Daum N, Lehr C, Schneider M, Lee S (2026)
ChemMedChem 21 (2)DOI: 10.1002/cmdc.202500810
Microphysiological ("organ-on-a-chip") models of pulmonary infections for developing novel anti-infectives
Rindchen A, Schneider-Daum N, Lehr C (2026)
Adv. Drug Deliv. Rev. 236DOI: 10.1016/j.addr.2026.115917
Exploring the Role of Pseudomonas aeruginosa Elastase in Lung Epithelial Barrier Dysfunction: Advancing toward Antivirulence Therapies
Shafiei R, Alhayek A, Hiller L, Latta L, Neu T, Aljohmani A, Abdollahibiroun S, Schönborn E, Yildiz D, Schneider-Daum N, …, Haupenthal J, Hirsch A (2026)
ACS Infect. Dis.DOI: 10.1021/acsinfecdis.5c00915
2025
Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections
Shekhar A, Di Lucrezia R, Jerye K, Korotkov V, Harmrolfs K, Rox K, Weich H, Ghai I, Delhommel F, Becher I, …, Dinkel K, Brönstrup M (2025)
Cell Host Microbe 33 (4): 560-572DOI: 10.1016/j.chom.2025.03.006
Mapping the ABC transporter landscape in the human lung: A comprehensive characterisation of P-gp, MRP1 and BCRP expression and functional activity in human lung epithelial cells
Simon S, Shanmugalingam T, Neu T, Schneider-Daum N, Cantrill C, Lehr C (2025)
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 215DOI: 10.1016/j.ejps.2025.107333
2024
A stretchable human lung‐on‐chip model of alveolar inflammation for evaluating anti‐inflammatory drug response
Richter C, Latta L, Harig D, Carius P, Stucki J, Hobi N, Hugi A, Schumacher P, Krebs T, Gamrekeli A, …, Schneider-Daum N, Lehr C (2024)
Bioengineering & Transla MedDOI: 10.1002/btm2.10715
A New Class of Polyion Complex Vesicles (PIC-somes) to Improve Antimicrobial Activity of Tobramycin in Pseudomonas Aeruginosa Biofilms
Yildirim T, Bali A, Koch M, Paul P, Latta L, Schneider-Daum N, Gallei M, Lehr C (2024)
Small (Weinheim an der Bergstrasse, Germany) 20 (40)DOI: 10.1002/smll.202401926
2023
A Monoclonal Human Alveolar Epithelial Cell Line ("Arlo") with Pronounced Barrier Function for Studying Drug Permeability and Viral Infections
Carius P, Jungmann A, Bechtel M, Grißmer A, Boese A, Gasparoni G, Salhab A, Seipelt R, Urbschat K, Richter C, …, Schneider-Daum N, Lehr C (2023)
Adv. Sci. 10 (8)DOI: 10.1002/advs.202207301
2022
An Outer Membrane Vesicle-Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability
Richter R, Kamal M, Koch M, Niebuur B, Huber A, Goes A, Volz C, Vergalli J, Kraus T, Müller R, …, Pagès J, Lehr C (2022)
Advanced healthcare materials 11 (5)DOI: 10.1002/adhm.202101180
Transferring Microclusters of P. aeruginosa Biofilms to the Air-Liquid Interface of Bronchial Epithelial Cells for Repeated Deposition of Aerosolized Tobramycin
Horstmann J, Laric A, Boese A, Yildiz D, Röhrig T, Empting M, Frank N, Krug D, Müller R, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2022)
ACS infectious diseases 8 (1): 137-149DOI: 10.1021/acsinfecdis.1c00444
2021
PerfuPul-A Versatile Perfusable Platform to Assess Permeability and Barrier Function of Air Exposed Pulmonary Epithelia
Carius P, Dubois A, Ajdarirad M, Artzy-Schnirman A, Sznitman J, Schneider-Daum N, Lehr C (2021)
Frontiers in Bioengineering and Biotechnology 9DOI: 10.3389/fbioe.2021.743236
Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane
Zamprogno P, Wüthrich S, Achenbach S, Thoma G, Stucki J, Hobi N, Schneider-Daum N, Lehr C, Huwer H, Geiser T, Schmid R, Guenat O (2021)
Communications Biology 4 (1)DOI: 10.1038/s42003-021-01695-0
Testing of aerosolized ciprofloxacin nanocarriers on cystic fibrosis airway cells infected with P. aeruginosa biofilms
Juntke J, Murgia X, Günday Türeli N, Türeli A, Thorn C, Schneider M, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2021)
Drug delivery and translational research 11 (4): 1752-1765DOI: 10.1007/s13346-021-01002-8
2020
Tobacco Smoke and Inhaled Drugs Alter Expression and Activity of Multidrug Resistance-Associated Protein-1 (MRP1) in Human Distal Lung Epithelial Cells in vitro
Selo M, Delmas A, Springer L, Zoufal V, Sake J, Clerkin C, Huwer H, Schneider-Daum N, Lehr C, Nickel S, Langer O, Ehrhardt C (2020)
Frontiers in Bioengineering and Biotechnology 8DOI: 10.3389/fbioe.2020.01030
A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria
Richter R, Kamal M, García-Rivera M, Kaspar J, Junk M, Elgaher W, Srikakulam S, Gress A, Beckmann A, Grißmer A, …, Schneider-Daum N, Lehr C (2020)
Materials today. Bio 8DOI: 10.1016/j.mtbio.2020.100084
Modulating the Barrier Function of Human Alveolar Epithelial (hAELVi) Cell Monolayers as a Model of Inflammation
Metz J, Wiegand B, Schnur S, Knoth K, Schneider-Daum N, Groß H, Croston G, Reinheimer T, Lehr C, Hittinger M (2020)
Alternatives to laboratory animals : ATLA 48 (5-6): 252-267DOI: 10.1177/0261192920983015
P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives
Montefusco-Pereira C, Horstmann J, Ebensen T, Beisswenger C, Bals R, Guzmán C, Schneider-Daum N, Carvalho-Wodarz C, Lehr C (2020)
Journal of visualized experiments : JoVE (160)DOI: 10.3791/61069
2019
Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline
Artzy-Schnirman A, Hobi N, Schneider-Daum N, Guenat O, Lehr C, Sznitman J (2019)
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 144: 11-17DOI: 10.1016/j.ejpb.2019.09.006
OCTN2-Mediated Acetyl-l-Carnitine Transport in Human Pulmonary Epithelial Cells In Vitro
Salomon J, Gausterer J, Selo M, Hosoya K, Huwer H, Schneider-Daum N, Lehr C, Ehrhardt C (2019)
Pharmaceutics 11 (8)DOI: 10.3390/pharmaceutics11080396
Capturing the Onset of Bacterial Pulmonary Infection in Acini‐On‐Chips
Artzy-Schnirman A, Zidan H, Elias-Kirma S, Ben-Porat L, Tenenbaum-Katan J, Carius P, Fishler R, Schneider-Daum N, Lehr C, Sznitman J (2019)
Adv. Biosys. 3 (9)DOI: 10.1002/adbi.201900026
2018
Co-culture of human alveolar epithelial (hAELVi) and macrophage (THP-1) cell lines
Kletting S, Barthold S, Repnik U, Griffiths G, Loretz B, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2018)
ALTEX 35 (2): 211-222DOI: 10.14573/altex.1607191
Medium throughput breathing human primary cell alveolus-on-chip model
Stucki J, Hobi N, Galimov A, Stucki A, Schneider-Daum N, Lehr C, Huwer H, Frick M, Funke-Chambour M, Geiser T, Guenat O (2018)
Scientific Reports 8 (1)DOI: 10.1038/s41598-018-32523-x
Murine alveolar epithelial cells and their lentivirus-mediated immortalisation
Sapich S, Hittinger M, Hendrix-Jastrzebski R, Repnik U, Griffiths G, May T, Wirth D, Bals R, Schneider-Daum N, Lehr C (2018)
Alternatives to laboratory animals : ATLA 46 (2): 73-89
Vibrational spectroscopic imaging and live cell video microscopy for studying differentiation of primary human alveolar epithelial cells
Vukosavljevic B, Hittinger M, Hachmeister H, Pilger C, Murgia X, Gepp M, Gentile L, Huwer H, Schneider-Daum N, Huser T, Lehr C, Windbergs M (2018)
Journal of biophotonicsDOI: 10.1002/jbio.201800052
In Vitro Model of the Gram-Negative Bacterial Cell Envelope for Investigation of Anti-Infective Permeation Kinetics
Graef F, Richter R, Fetz V, Murgia X, Rossi C, Schneider-Daum N, Allegretta G, Elgaher W, Haupenthal J, Empting M, …, Gordon S, Lehr C (2018)
ACS infectious diseases 4 (8): 1188-1196DOI: 10.1021/acsinfecdis.7b00165
2017
Cell and tissue-based in vitro models for improving the development of oral inhalation drug products
Hittinger M, Schneider-Daum N, Lehr C (2017)
European Journal of Pharmaceutics and Biopharmaceutics 118: 73-78DOI: 10.1016/j.ejpb.2017.02.019
Nanoencapsulation of a glucocorticoid improves barrier function and anti-inflammatory effect on monolayers of pulmonary epithelial cell lines
Rigo L, Carvalho-Wodarz C, Pohlmann A, Guterres S, Schneider-Daum N, Lehr C, Beck R (2017)
European Journal of Pharmaceutics and BiopharmaceuticsDOI: 10.1016/j.ejpb.2017.05.006
Expression and Activity of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Distal Lung Epithelial Cells In Vitro
Nickel S, Selo M, Fallack J, Clerkin C, Huwer H, Schneider-Daum N, Lehr C, Ehrhardt C (2017)
Pharmaceutical researchDOI: 10.1007/s11095-017-2172-9
Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections
Castoldi A, Herr C, Niederstraßer J, Labouta H, Melero A, Gordon S, Schneider-Daum N, Bals R, Lehr C (2017)
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 118: 62-67DOI: 10.1016/j.ejpb.2016.11.026
Ciprofloxacin-loaded PLGA nanoparticles against cystic fibrosis P. aeruginosa lung infections
Günday Türeli N, Torge A, Juntke J, Schwarz B, Schneider-Daum N, Türeli A, Lehr C, Schneider M (2017)
European Journal of Pharmaceutics and Biopharmaceutics 117: 363-371DOI: 10.1016/j.ejpb.2017.04.032
Lung alveoli array-on-chip with a bioartificial membrane
Zamprogno P, Achenbach S, Stucki J, Hobi N, Schneider-Daum N, Lehr C, Huwer H, Schmid R, Guenat O (2017)
Toxicology letters 280DOI: 10.1016/j.toxlet.2017.07.974
2016
Surface-modified yeast cells: A novel eukaryotic carrier for oral application
Kenngott E, Kiefer R, Schneider-Daum N, Hamann A, Schneider M, Schmitt M, Breinig F (2016)
Journal of controlled release : official journal of the Controlled Release Society 224: 1-7DOI: 10.1016/j.jconrel.2015.12.054
Autologous co-culture of primary human alveolar macrophages and epithelial cells for investigating aerosol medicines. Part I: Model Characterisation
Hittinger M, Janke J, Huwer H, Scherließ R, Schneider-Daum N, Lehr C (2016)
ATLA Alternatives to Laboratory Animals 44 (4): 337-347
Autologous co-culture of primary human alveolar macrophages and epithelial cells for investigating aerosol medicines. Part II: evaluation of IL-10-loaded microparticles for the treatment of lung inflammation
Hittinger M, Mell N, Huwer H, Loretz B, Schneider-Daum N, Lehr C (2016)
Alternatives to laboratory animals : ATLA 44 (4): 349-360
A 3D co-culture of three human cell lines to model the inflamed intestinal mucosa for safety testing of nanomaterials
Susewind J, Souza Carvalho-Wodarz C, Repnik U, Collnot E, Schneider-Daum N, Griffiths G, Lehr C (2016)
Nanotoxicology 10 (1): 53-62DOI: 10.3109/17435390.2015.1008065
IL-17A-mediated expression of epithelial IL-17C promotes inflammation during acute Pseudomonas aeruginosa pneumonia
Wolf L, Sapich S, Honecker A, Jungnickel C, Seiler F, Bischoff M, Wonnenberg B, Herr C, Schneider-Daum N, Lehr C, Bals R, Beisswenger C (2016)
American Journal of Physiology - Lung Cellular and Molecular Physiology 311 (5): 1015-DOI: 10.1152/ajplung.00158.2016
Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier
Kuehn A, Kletting S, Souza Carvalho-Wodarz C, Repnik U, Griffiths G, Fischer U, Meese E, Huwer H, Wirth D, May T, Schneider-Daum N, Lehr C (2016)
ALTEX 33 (3): 251-60DOI: 10.14573/altex.1511131
2015
Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models
Hittinger M, Juntke J, Kletting S, Schneider-Daum N, de Souza Carvalho C, Lehr C (2015)
Advanced Drug Delivery Reviews 85: 44-56DOI: 10.1016/j.addr.2014.10.011
P-glycoprotein interactions of novel psychoactive substances - stimulation of ATP consumption and transport across Caco-2 monolayers
Meyer M, Wagmann L, Schneider-Daum N, Loretz B, Souza Carvalho C, Lehr C, Maurer H (2015)
Biochemical pharmacology 94 (3): 220-6DOI: 10.1016/j.bcp.2015.01.008
Expression and function of the epithelial sodium channel δ-subunit in human respiratory epithelial cells in vitro
Schwagerus E, Sladek S, Buckley S, Armas-Capote N, La Rosa D, Harvey B, Fischer H, Illek B, Huwer H, Schneider-Daum N, Lehr C, Ehrhardt C (2015)
Pflugers Archiv European Journal of Physiology 467 (11): 2257-2273DOI: 10.1007/s00424-015-1693-5
Macrophage uptake of cylindrical microparticles investigated with correlative microscopy
Tscheka C, Hittinger M, Lehr C, Schneider-Daum N, Schneider M (2015)
European Journal of Pharmaceutics and Biopharmaceutics 95: 151-155DOI: 10.1016/j.ejpb.2015.03.010
Mono- and Cocultures of Bronchial and Alveolar Epithelial Cells Respond Differently to Proinflammatory Stimuli and Their Modulation by Salbutamol and Budesonide
Haghi M, Hittinger M, Zeng Q, Oliver B, Traini D, Young P, Huwer H, Schneider-Daum N, Lehr C (2015)
Molecular pharmaceutics 12 (8): 2625-32DOI: 10.1021/acs.molpharmaceut.5b00124
Organic cation transporter function in different in vitro models of human lung epithelium
Salomon J, Gausterer J, Yahara T, Hosoya K, Huwer H, Hittinger M, Schneider-Daum N, Lehr C, Ehrhardt C (2015)
European Journal of Pharmaceutical Sciences 80: 82-88DOI: 10.1016/j.ejps.2015.08.007