Publikationen

Publikations-Highlights

Werfen Sie einen Blick auf unsere neuesten Entdeckungen.

Functional Materials to Overcome Bacterial Barriers and Models to Advance Their Development

HypoRiPPAtlas as an Atlas of hypothetical natural products for mass spectrometry database search

Discovery and Characterization of a Myxobacterial Lanthipeptide with Unique Biosynthetic Features and Anti-inflammatory Activity

Atlas of the aging mouse brain reveals white matter as vulnerable foci

Revision of the Absolute Configurations of Chelocardin and Amidochelocardin

3D bioprinting of E. coli MG1655 biofilms on human lung epithelial cells for building complex in vitro infection models

Isolation, (bio)synthetic studies and evaluation of antimicrobial properties of drimenol-type sesquiterpenes of Termitomyces fungi

Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues

A Monoclonal Human Alveolar Epithelial Cell Line (“Arlo”) with Pronounced Barrier Function for Studying Drug Permeability and Viral Infections

Persicamidines—Unprecedented Sesquarterpenoids with Potent Antiviral Bioactivity against Coronaviruses

Thiamyxins: Structure and Biosynthesis of Myxobacterial RNA-Virus Inhibitors

Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis

Natural Products Lysobactin and Sorangicin A Show In Vitro Activity against Mycobacterium abscessus Complex

Publikationsdatenbank

2025

Natural products chlorotonils exert a complex antibacterial mechanism and address multiple targets

Deschner F, Mostert D, Daniel J, Voltz A, Schneider D, Khangholi N, Bartel J, Pessanha de Carvalho L, Brauer M, Gorelik T, …, Müller R, Herrmann J (2025)

Cell Chem. Biol.DOI: 10.1016/j.chembiol.2025.03.005

Chemical Proteomics Reveals Human Off-Targets of Fluoroquinolone Induced Mitochondrial Toxicity

Reinhardt T, El Harraoui Y, Rothemann A, Jauch A, Müller-Deubert S, Köllen M, Risch T, Jacobs L, Müller R, Traube F, …, Bach N, Sieber S (2025)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202421424

Postulations for the Migration Behavior of Amino Acids as Cations in Capillary Zone Electrophoresis

Gross P, Huber T, Lunow I, Burkhard D, Seelert H, Müller R (2025)

ElectrophoresisDOI: 10.1002/elps.202400205

ClpP2 proteasomes and SpxA1 determine Listeria monocytogenes tartrolon B hyper-resistance

Engelgeh T, Wamp S, Rothe P, Herrmann J, Fischer M, Müller R, Halbedel S (2025)

PLOS Genetics 21 (4)DOI: 10.1371/journal.pgen.1011621

The fungal natural product class of the sorbicillinoids: structures, bioactivities, biosynthesis, and synthesis

Milzarek T, Gulder T (2025)

Nat. Prod. Rep. 42: 482-500DOI: 10.1039/D4NP00059E

Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance

Rasheed S, Umstätter F, Mühlberg E, Beijer B, Hertlein T, Klika K, Kleist C, Werner J, Domhan C, Bingel M, …, Mier W, Uhl P (2025)

Adv. Therap.DOI: 10.1002/adtp.202400473

Gromomycins: An Unprecedented Class of Triterpene Antibiotics Produced by a Novel Biosynthetic Pathway

Luzhetskyy A, Tistechok S, Bratiichuk D, Sucipto H, Gummerlich N, Stierhof M, Fries F, Müller R, Zapp J, Myronovskyi M, Gromyko O, Fedorenko V (2025)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202422270

MIBiG 4.0: Advancing biosynthetic gene cluster curation through global collaboration

Zdouc M, Blin K, Louwen N, Navarro J, Loureiro C, Bader C, Bailey C, Barra L, Booth T, Bozhüyük K, …, Weber T, Medema M (2025)

Nucleic Acids Research 53 (D1): 678-690DOI: 10.1093/nar/gkae1115

Discovery of a novel, selective CK2 inhibitor class with an unusual basic scaffold

Khalifa H, ElHady A, Liu T, Elgaher W, Filhol-Cochet O, Cochet C, Abadi A, Hamed M, Abdel-Halim M, Engel M (2025)

European journal of medicinal chemistry 282DOI: 10.1016/j.ejmech.2024.117048

Heterologous Expression and Optimization of Fermentation Conditions for Recombinant Ikarugamycin Production

Evers J, Glöckle A, Wiegand M, Schuler S, Einsiedler M, Gulder T (2025)

Biotechnol. Bioeng. 122 (4): 974-982DOI: 10.1002/bit.28919

Homophenylalanine-derived benzo1,4diazepine-2,5-diones are strong bacterial quorum sensing inhibitors

Einsiedler M, Bogojevic S, Milivojevic D, Vojnovic S, Milcic M, Maslak V, Matura A, Gulder T, Nikodinovic-Runic J (2025)

Org. Biomol. Chem. 23 (4): 835-843DOI: 10.1039/d4ob01734j

Heterologous Expression of a Cryptic BGC from Bilophila sp. Provides Access to a Novel Family of Antibacterial Thiazoles

Hohmann M, Iliasov D, Larralde M, Johannes W, Janßen K, Zeller G, Mascher T, Gulder T (2025)

ACS Synth. Biol. 14 (3): 967-978DOI: 10.1021/acssynbio.5c00042

Expanding Polycyclic Tetramate Macrolactam (PoTeM) Core Structure Diversity by Chemo-Enzymatic Synthesis and Bioengineering

Schuler S, Einsiedler M, Evers J, Malay M, Uka V, Schneider S, Gulder T (2025)

Angew. Chem. Int. Ed. 64 (13)DOI: 10.1002/anie.202420335

A plug-and-play system for polycyclic tetramate macrolactam production and functionalization

Glöckle A, Schuler S, Einsiedler M, Gulder T (2025)

Microb. Cell Fact. 24 (1)DOI: 10.1186/s12934-024-02630-8

The Maculalactone Biosynthetic Gene Cluster, a Cryptic Furanolide Pathway Revealed in Nodularia sp. NIES-3585

D’Agostino P, Castro R, Uka V, Saurav K, Milzarek T, Sester A, Schneider M, Gulder T (2025)

bioRxivDOI: 10.1101/2025.02.26.640319

BGC Atlas: a web resource for exploring the global chemical diversity encoded in bacterial genomes

Bagci C, Nuhamunada M, Goyat H, Ladanyi C, Sehnal L, Blin K, Kautsar S, Tagirdzhanov A, Gurevich A, Mantri S, …, Weber T, Ziemert N (2025)

Nucleic Acids Res 53 (D1): 618-DOI: 10.1093/nar/gkae953

From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds

Keddis P, My Tu T, Scherer H, Kany A, Hafez D, Darwish S, Abadi A, Hirsch A, Engel M, Hamed M, Horng J, Abdel-Halim M (2025)

Eur. J. Med. Chem. 287DOI: 10.1016/j.ejmech.2025.117348

Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model

Kiefer A, Schütz C, Englisch C, Kolling D, Speicher S, Kany A, Shafiei R, Wadood N, Aljohmani A, Wirschem N, …, Haupenthal J, Hirsch A (2025)

Adv. Sci.DOI: 10.1002/advs.202411807

Unlocking the Antiviral Arsenal: Structure-Guided Optimization of Small-Molecule Inhibitors against RSV and hCoV-229E

Karhan C, Sake S, Gunesch A, Grethe C, Hellwinkel B, Köhler N, Kiefer A, Hapko U, Kany A, Pietschmann T, Hirsch A (2025)

European journal of medicinal chemistryDOI: 10.1016/j.ejmech.2025.117282

PEARL: Protein Eluting Alginate with Recombinant Lactobacilli

Tadimarri V, Blanch-Asensio M, Deshpande K, Baumann J, Baumann C, Müller R, Trujillo S, Sankaran S (2025)

Small (Weinheim an der Bergstrasse, Germany)DOI: 10.1002/smll.202408316

Uncovering the genetic basis of antiviral polyketide limocrocin biosynthesis through heterologous expression

Melnyk S, Stierhof M, Bratiichuk D, Fries F, Müller R, Rebets Y, Luzhetskyy A, Ostash B (2025)

Microb. Cell Fact. 24 (1)DOI: 10.1186/s12934-024-02621-9

Targeting IspD for Anti-infective and Herbicide Development: Exploring Its Role, Mechanism, and Structural Insights

Willocx D, Diamanti E, Hirsch A (2025)

Journal of medicinal chemistryDOI: 10.1021/acs.jmedchem.4c01146

Apo structure of Mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate synthase DXPS: Dynamics and implications for inhibitor design

Gawriljuk V, Alhayek A, Hirsch A, Groves M (2025)

Biochemical and Biophysical Research Communications 747DOI: 10.1016/j.bbrc.2024.151246

The PLSDB 2025 update: enhanced annotations and improved functionality for comprehensive plasmid research

Molano L, Hirsch P, Hannig M, Müller R, Keller A (2025)

Nucleic Acids Res 53 (D1): 189-DOI: 10.1093/nar/gkae1095

2024

High-Affinity Lectin Ligands Enable the Detection of Pathogenic Pseudomonas aeruginosa Biofilms: Implications for Diagnostics and Therapy

Zahorska E, Denig L, Lienenklaus S, Kuhaudomlarp S, Tschernig T, Lipp P, Munder A, Gillon E, Minervini S, Verkhova V, …, Wagner S, Titz A (2024)

JACS Au 4 (12): 4715-4728DOI: 10.1021/jacsau.4c00670

A fucose-binding superlectin from Enterobacter cloacae with high Lewis and ABO blood group antigen specificity

Beshr G, Sikandar A, Gläser J, Fares M, Sommer R, Wagner S, Köhnke J, Titz A (2024)

J. Biol. Chem.DOI: 10.1016/j.jbc.2024.108151

In Vivo Activity Profiling of Biosynthetic Darobactin D22 against Critical Gram-Negative Pathogens

Kany A, Fries F, Seyfert C, Porten C, Deckarm S, Chacón Ortiz M, Dubarry N, Vaddi S, Große M, Bernecker S, …, Herrmann J, Müller R (2024)

ACS Infect. Dis. 10 (12): 4337-4346DOI: 10.1021/acsinfecdis.4c00687

Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD

Willocx D, D'Auria L, Walsh D, Scherer H, Alhayek A, Hamed M, Borel F, Diamanti E, Hirsch A (2024)

Angew. Chem., Int. Ed. Engl.DOI: 10.1002/anie.202414615

Targeting Plasmodium falciparum IspD in the Methyl-d-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity

Willocx D, Bizzarri L, Alhayek A, Kannan D, Bravo P, Illarionov B, Rox K, Lohse J, Fischer M, Kany A, …, Diamanti E, Hirsch A (2024)

Journal of medicinal chemistry 67 (19): 17070-17086DOI: 10.1021/acs.jmedchem.4c00212

Autologous DNA mobilization and multiplication expedite natural products discovery from bacteria

Xie F, Zhao H, Liu J, Yang X, Neuber M, Agrawal A, Kaur A, Herrmann J, Kalinina O, Wei X, Müller R, Fu C (2024)

Science 386 (6727)DOI: 10.1126/science.abq7333

A New Class of Polyion Complex Vesicles (PIC-somes) to Improve Antimicrobial Activity of Tobramycin in Pseudomonas Aeruginosa Biofilms

Yildirim T, Bali A, Koch M, Paul P, Latta L, Schneider-Daum N, Gallei M, Lehr C (2024)

Small (Weinheim an der Bergstrasse, Germany) 20 (40)DOI: 10.1002/smll.202401926

A Novel 3D Printed Model of Infected Human Hair Follicles to Demonstrate Targeted Delivery of Nanoantibiotics

Aliyazdi S, Frisch S, Neu T, Veldung B, Karande P, Schaefer U, Loretz B, Vogt T, Lehr C (2024)

ACS biomaterials science & engineering 10 (8): 4947-4957DOI: 10.1021/acsbiomaterials.4c00570

Discovery of the Pendulisporaceae: An extremotolerant myxobacterial family with distinct sporulation behavior and prolific specialized metabolism

Garcia R, Popoff A, Bader C, Löhr J, Walesch S, Walt C, Boldt J, Bunk B, Haeckl F, Gunesch A, …, Bach T, Müller R (2024)

Chem 10: 1-20DOI: 10.1016/j.chempr.2024.04.019

Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application

Hofer W, Deschner F, Jézéquel G, Pessanha de Carvalho L, Abdel-Wadood N, Pätzold L, Bernecker S, Morgenstern B, Kany A, Große M, …, Herrmann J, Müller R (2024)

Angewandte Chemie (International ed. in English) 63 (19)DOI: 10.1002/anie.202319765

Dual inhibitors of Pseudomonas aeruginosa virulence factors LecA and LasB

Metelkina O, Konstantinovic J, Klein A, Shafiei R, Fares M, Alhayek A, Yahiaoui S, Elgaher W, Haupenthal J, Titz* A, Hirsch* A (2024)

Chem. Sci. 15DOI: 10.1039/D4SC02703E

Identification by Synthesis: Imidacins, Urocanate-Derived Alkaloids from the Myxobacterium Stigmatella aurantiaca

Kostka M, Krug D, Herrmann J, Dickschat J, Meyer J, Müller R, Schulz S (2024)

Org. Lett.DOI: 10.1021/acs.orglett.4c02036

SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination

Iram T, Garcia M, Amand J, Kaur A, Atkins M, Iyer M, Lam M, Ambiel N, Jorgens D, Keller A, …, Kern F, Zuchero J (2024)

Proc. Natl. Acad. Sci. U.S.A. 121 (12)DOI: 10.1073/pnas.2307250121

The Peptide Antibiotic Corramycin Adopts a β-Hairpin-like Structure and Is Inactivated by the Kinase ComG

Adam S, Fries F, Tesmar A, Rasheed S, Deckarm S, Sousa C, Reberšek R, Risch T, Mancini S, Herrmann J, …, Kalinina O, Müller R (2024)

J. Am. Chem. Soc.DOI: 10.1021/jacs.3c13208

ZEBRA: a hierarchically integrated gene expression atlas of the murine and human brain at single-cell resolution

Flotho M, Amand J, Hirsch P, Grandke F, Wyss-Coray T, Keller A, Kern F (2024)

Nucleic Acids Res 52 (D1): 1089-DOI: 10.1093/nar/gkad990

Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins

Fu C, Liu Y, Walt C, Rasheed S, Bader C, Lukat P, Neuber M, Haeckl F, Blankenfeldt W, Kalinina O, Müller R (2024)

Nat Commun 15 (1)DOI: 10.1038/s41467-024-44953-5

S75 | CyanoMetDB | Comprehensive database of secondary metabolites from cyanobacteria - Version 03

Janssen E, Jones M, Pinto E, Dörr F, Torres M, Rios Jacinavicius F, Mazur-Marzec H, Szubert K, Konkel R, Tartaglione L, …, Reher R, Sieber S (2024)

BookDOI: 10.5281/zenodo.13854577

The underestimated fraction: diversity, challenges and novel insights into unicellular cyanobionts of lichens

Jung P, Briegel-Williams L, Büdel B, Schultz M, Nürnberg D, Grube M, D’Agostino P, Kaštovský J, Mareš J, Lorenz M, …, INCb, International Network for research on unicellular CyanoBionts from lichens (2024)

ISME Commun. 4 (1)DOI: 10.1093/ismeco/ycae069

Phylometagenomics of cycad coralloid roots reveals shared symbiotic signals

Bustos-Diaz E, Cruz-Perez A, Garfias-Gallegos D, D'Agostino P, Gehringer M, Cibrian-Jaramillo A, Barona-Gomez F (2024)

Microb. Genom. 10 (3)DOI: 10.1099/mgen.0.001207

Citraconic acid and derivatives thereof for use as a medicament

Frank Pessler, Fangfang Chen, Moritz Winterhoff, Konrad Büssow, Wulf Blankenfeldt, Anna Hirsch, Walid A. M. Elgaher (2024)

Patent A61K31/122; A61K31/194; A61P31/16; C07C57/42; C07C61/20; C07C69/593; (US20240368065A1)

Author Correction: Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

Kurmasheva N, Said A, Wong B, Kinderman P, Han X, Rahimic A, Kress A, Carter-Timofte M, Holm E, van der Horst D, …, Alain T, Olagnier D (2024)

Nat Commun 15 (1)DOI: 10.1038/s41467-024-55044-w

Novel and Extremely Sensitive NiAl2O4-NiO Nanostructures on an ITO Sensing Electrode for Enhanced Detection of Ascorbic Acid

Hammami A, Bardaoui A, Eissa S, Elgaher W, Chtourou R, Messaoud O (2024)

Molecules (Basel, Switzerland) 29 (12)DOI: 10.3390/molecules29122837

Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

Kurmasheva N, Said A, Wong B, Kinderman P, Han X, Rahimic A, Kress A, Carter-Timofte M, Holm E, van der Horst D, …, Alain T, Olagnier D (2024)

Nat Commun 15 (1)DOI: 10.1038/s41467-024-48422-x

Functionalization of silk with actinomycins from Streptomyces anulatus BV365 for biomedical applications

Ilic-Tomic T, Kramar A, Kostic M, Vojnovic S, Milovanovic J, Petkovic M, D'Agostino P, Gulder T, Nikodinovic-Runic J (2024)

Front. Bioeng. Biotechnol. 12DOI: 10.3389/fbioe.2024.1466757

Bacillamide D produced by Bacillus cereus from the mouse intestinal bacterial collection (miBC) is a potent cytotoxin in vitro

Hohmann M, Brunner V, Johannes W, Schum D, Carroll L, Liu T, Sasaki D, Bosch J, Clavel T, Sieber S, …, Janßen K, Gulder T (2024)

Commun. Biol. 7 (1)DOI: 10.1038/s42003-024-06208-3

Chemoenzymatic total synthesis of sorbicillactone A

Müller J, Gulder T (2024)

Commun. Chem. 7 (1)DOI: 10.1038/s42004-024-01126-1

Biosynthesis of brevinic acid from lawsone

Hohmann M, Ohlrogge J, Gulder T (2024)

Org. Biomol. Chem. 22 (34): 7035-7038DOI: 10.1039/D4OB01184H

Product Selectivity in Baeyer-Villiger Monooxygenase-Catalyzed Bacterial Alkaloid Core Structure Maturation

Einsiedler M, Lamm K, Ohlrogge J, Schuler S, Richter I, Lübken T, Gulder T (2024)

J. Am. Chem. Soc. 146 (23): 16203-16212DOI: 10.1021/jacs.4c04115

Synthesis and antibiotic potential of myxocoumarin-inspired chromene dione analogs

Behnsen A, Hertrampf G, Vojnovic S, Nikodinovic-Runic J, Gulder T (2024)

RSC Adv. 14 (47): 35215-35219DOI: 10.1039/D4RA05941G

Decoding the diagnostic and therapeutic potential of microbiota using pan-body pan-disease microbiomics

Schmartz G, Rehner J, Gund M, Keller V, Molano L, Rupf S, Hannig M, Berger T, Flockerzi E, Seitz B, …, Bals R, Keller A (2024)

Nat. Commun. 15 (1)DOI: 10.1038/s41467-024-52598-7

Discovery and biosynthesis of non-canonical C16-terpenoids from Pseudomonas

Mo X, Pu Q, Lübken T, Yu G, Malay M, D'Agostino P, Gulder T (2024)

Cell Chem. Biol. 31 (12): 2128-2137DOI: 10.1016/j.chembiol.2024.09.002

Exploring microbial diversity and biosynthetic potential in zoo and wildlife animal microbiomes

Schmartz G, Rehner J, Schuff M, Molano L, Becker S, Krawczyk M, Tagirdzhanov A, Gurevich A, Francke R, Müller R, Keller V, Keller A (2024)

Nat Commun 15 (1)DOI: 10.1038/s41467-024-52669-9

The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity

Kalkreuter E, Kautsar S, Yang D, Bader C, Teijaro C, Fluegel L, Davis C, Simpson J, Lauterbach L, Steele A, …, Carvalho L, Shen B (2024)

bioRxivDOI: 10.1101/2023.12.14.571759

Evolution-inspired engineering of nonribosomal peptide synthetases

Bozhüyük K, Präve L, Kegler C, Schenk L, Kaiser S, Schelhas C, Shi Y, Kuttenlochner W, Schreiber M, Kandler J, …, Hochberg G, Bode H (2024)

Science 383 (6689)DOI: 10.1126/science.adg4320

Behavioral and electrophysiological responses of the male medfly, Ceratitis capitata, to thymol and carvacrol ethers

Tabanca N, Cloonan K, Nesterkina M, Gill M, Montgomery W, Kravchenko I, Kendra P (2024)

Pest management scienceDOI: 10.1002/ps.8324

Synthesis and Structure of a Coordination Polymer of Ni(II) with 2-(4-Bromophenoxy)acetohydrazide

Martsynko ?, Nesterkina M, Finik ?, Tsymbaliuk K, Dyakonenko V, Shishkina S, Kravchenko I (2024)

Molbank 2024 (2)DOI: 10.3390/M1819

Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes

Geißler A, Junca H, Kany A, Daumann L, Hirsch A, Pieper D, Sieber S (2024)

Chem. Sci. 15 (30): 11946-11955DOI: 10.1039/D4SC01940G

Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery**

Afanasenko A, Wu X, Santi A, Elgaher W, Kany A, Shafiei R, Schulze M, Schulz T, Haupenthal J, Hirsch A, Barta K (2024)

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 136 (4)DOI: 10.1002/ange.202308131

Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity

Mielniczuk S, Hoff K, Baselious F, Li Y, Haupenthal J, Kany A, Riedner M, Rohde H, Rox K, Hirsch A, …, Sippl W, Holl R (2024)

Journal of medicinal chemistry 67 (19): 17363-17391DOI: 10.1021/acs.jmedchem.4c01262

Spray drying of a zinc complexing agent for inhalation therapy of pulmonary fibrosis

Stella J, Abdelaal M, Kamal M, Shehu K, Alhayek A, Haupenthal J, Hirsch A, Schneider M (2024)

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 202DOI: 10.1016/j.ejps.2024.106891

Journal of Medicinal Chemistry Collection: Drug Discovery in Germany

Laufer S, Gehringer M, Titz A (2024)

Journal of medicinal chemistry 67 (4)DOI: 10.1021/acs.jmedchem.4c00122

Glycomimetics as Candidates for Treatment and Prevention of Catheter-associated Biofilms Formed by Pseudomonas aeruginosa

Vogel C, Rox K, Wagenlehner F, Titz A (2024)

European urology focus 10 (5): 720-721DOI: 10.1016/j.euf.2024.08.011

Synthetic studies on the tetrasubstituted D-ring of cystobactamids lead to potent terephthalic acid antibiotics

Stappert M, Kohnhäuser D, Seedorf T, Coetzee J, Rox K, Fuchs H, Cirnski K, Leitner C, Herrmann J, Kirschning A, Müller R, Brönstrup M (2024)

Commun Chem 7 (1)DOI: 10.1038/s42004-024-01337-6

Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens

Fenwick M, Pierce P, Abendroth J, Barrett K, Barrett L, Bowatte K, Choi R, Chun I, Conrady D, Craig J, …, Edwards T, Myler P (2024)

Communications Biology 7 (1)DOI: 10.1038/s42003-024-07175-5

IspE kinase as an anti-infective target: Role of a hydrophobic pocket in inhibitor binding

Hamid R, Walsh D, Diamanti E, Aguilar D, Lacour A, Hamed M, Hirsch A (2024)

Structure (London, England : 1993) 32 (12): 2390-2398DOI: 10.1016/j.str.2024.10.009

Targeting the Plasmodium falciparum IspE Enzyme

Diamanti E, Steinbach A, Carvalho L, Ropponen H, Lacour A, Hamid R, Eisa S, Bravo P, Bousis S, Illarionov B, …, Sieber S, Hirsch A (2024)

ACS omega 9 (44): 44465-44473DOI: 10.1021/acsomega.4c06038

Expression and characterization of pantothenate energy-coupling factor transporters as an anti-infective drug target

Shams A, Bousis S, Diamanti E, Elgaher W, Zeimetz L, Haupenthal J, slotboom d, Hirsch A (2024)

Protein Sci. 33 (11)DOI: 10.1002/pro.5195

Studying Target-Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry

Bizzarri L, Steinbrunn D, Quennesson T, Lacour A, Bianchino G, Bravo P, Chaignon P, Lohse J, Mäser P, Seemann M, …, Hirsch A, Hahne H (2024)

ACS Infect. Dis. 10 (12): 4087-4102DOI: 10.1021/acsinfecdis.4c00417

Integral Solvent-Induced Protein Precipitation for Target-Engagement Studies in Plasmodium falciparum

Bravo P, Bizzarri L, Steinbrunn D, Lohse J, Hirsch A, Mäser P, Rottmann M, Hahne H (2024)

ACS Infect. Dis. 10 (12): 4073-4086DOI: 10.1021/acsinfecdis.4c00418

Dynamic Combinatorial Chemistry Unveils Nsp10 Inhibitors with Antiviral Potential Against SARS-CoV-2

Jumde R, Jézéquel G, Saramago M, Frank N, Adam S, Cunha M, Bader C, Gunesch A, Köhler N, Johannsen S, …, Arraiano C, Hirsch A (2024)

Chem. - Eur. J.DOI: 10.1002/chem.202403390

Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery

Liu Y, Hamm T, Eichinger T, Kamm W, Wieland H, Loretz B, Hirsch A, Lee S, Lehr C (2024)

Int. J. Nanomedicine 19: 4429-4449DOI: 10.2147/IJN.S448578

A stretchable human lung‐on‐chip model of alveolar inflammation for evaluating anti‐inflammatory drug response

Richter C, Latta L, Harig D, Carius P, Stucki J, Hobi N, Hugi A, Schumacher P, Krebs T, Gamrekeli A, …, Schneider-Daum N, Lehr C (2024)

Bioengineering & Transla MedDOI: 10.1002/btm2.10715

Design and evaluation of nanostructured lipid carrier of Bergenin isolated from Pentaclethra macrophylla for anti-inflammatory effect on lipopolysaccharide-induced inflammatory responses in macrophages

Nnamani P, Nwagwu C, Diovu E, Abonyi O, Nesterkina M, Neu T, Richter C, Loretz B, Lehr C (2024)

Eur J Pharm Biopharm 200DOI: 10.1016/j.ejpb.2024.114307

Biopolymeric and lipid-based nanotechnological strategies for the design and development of novel mosquito repellent systems: recent advances

Nwagwu C, Onugwu A, Echezona A, Uzondu S, Agbo C, Kenechukwu F, Ogbonna J, Ugorji L, Nwobi L, Nwobi O, …, Lehr C, Attama A (2024)

Nanoscale advances 6 (19): 4751-80DOI: 10.1039/d4na00474d

Identification of inhibitors targeting the energy-coupling factor (ECF) transporters

Diamanti E, Souza P, Setyawati I, Bousis S, Monjas L, Swier L, Shams A, Tsarenko A, Stanek W, Jäger M, …, slotboom d, Hirsch A (2024)

Communications Biology 7 (1)DOI: 10.1038/s42003-024-05770-0

Thermo-amplifier circuit in probiotic E. coli for stringently temperature-controlled release of a novel antibiotic

Dey S, Seyfert C, Fink-Straube C, Kany A, Müller R, Sankaran S (2024)

Journal of biological engineering 18 (1)DOI: 10.1186/s13036-024-00463-y

Olikomycin A-A Novel Calcium-Dependent Lipopeptide with Antibiotic Activity Against Multidrug-Resistant Bacteria

Makitrynskyy R, Keller L, Kaur A, Tsypik O, Munz L, Bechthold A, Müller R (2024)

Chem. Eur. J.DOI: 10.1002/chem.202403985

Structure Revision of Halisphingosine A via Total Synthesis and Bioactivity Studies

Sauer M, Kany A, Götze S, Müller R, Beemelmanns C (2024)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202416036

Realizing time-staggered expression of nucleic acid-encoded proteins by co-delivery of messenger RNA and plasmid DNA on a single nanocarrier

Nasr S, Paul P, Loretz B, Lehr C (2024)

Drug delivery and translational research 14 (12): 3339-3353DOI: 10.1007/s13346-024-01668-w

Harnessing Gram-negative bacteria for novel anti-Gram-negative antibiotics

Birkelbach J, Seyfert C, Walesch S, Müller R (2024)

Microbial Biotechnology 17 (11)DOI: 10.1111/1751-7915.70032

Comparative genomics unravels a rich set of biosynthetic gene clusters with distinct evolutionary trajectories across fungal species (Termitomyces) farmed by termites

Schmidt S, Murphy R, Vizueta J, Schierbech S, Conlon B, Kreuzenbeck N, Vreeburg S, van de Peppel L, Aanen D, Silué K, …, Weber T, Poulsen M (2024)

Commun Biol 7 (1)DOI: 10.1038/s42003-024-06887-y

Antimicrobial and antibiotic-potentiating effect of calcium peroxide nanoparticles on oral bacterial biofilms

Bankar N, Latta L, Loretz B, Reda B, Dudek J, Hähl H, Hannig M, Lehr C (2024)

npj Biofilms and Microbiomes 10 (1)DOI: 10.1038/s41522-024-00569-7

Interaction of the Atypical Tetracyclines Chelocardin and Amidochelocardin with Renal Drug Transporters

Rox K, Kühne A, Herrmann J, Jansen R, Hüttel S, Bernecker S, Hagos Y, Brönstrup M, Stadler M, Hesterkamp T, Müller R (2024)

ACS Pharmacol. Transl. Sci. 7 (7): 2093-2109DOI: 10.1021/acsptsci.4c00183

Bacteria from the Amycolatopsis genus associated with a toxic bird secrete protective secondary metabolites

Seibel E, Um S, Bodawatta K, Komor A, Decker T, Fricke J, Murphy R, Maiah G, Iova B, Maus H, …, Poulsen M, Beemelmanns C (2024)

Nat Commun 15 (1)DOI: 10.1038/s41467-024-52316-3

Statistical analysis of feature-based molecular networking results from non-targeted metabolomics data

Pakkir Shah A, Walter A, Ottosson F, Russo F, Navarro-Diaz M, Boldt J, Kalinski J, Kontou E, Elofson J, Polyzois A, …, Ernst M, Petras D (2024)

Nature protocolsDOI: 10.1038/s41596-024-01046-3

Optimization of the Central α-Amino Acid in Cystobactamids to the Broad-Spectrum, Resistance-Breaking Antibiotic CN-CC-861

Kohnhäuser D, Seedorf T, Cirnski K, Heimann D, Coetzee J, Sordello S, Richter J, Stappert M, Sabuco J, Corbett D, …, Kirschning A, Brönstrup M (2024)

J. Med. Chem.DOI: 10.1021/acs.jmedchem.4c00927&ref=pdf

Isofunctional but Structurally Different Methyltransferases for Dithiolopyrrolone Diversification

Su L, Huber E, Westphalen M, Gellner J, Bode E, Köbel T, Grün P, Alanjary M, Glatter T, Cirnski K, …, Groll M, Bode H (2024)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202410799

The HIPS 2024 symposium: highlighting advances in pharmaceutical sciences in infection research

Mayoka G, Krug D, Loretz B, Bozhüyük K, Empting M, Hirsch A, Müller R (2024)

Trends in MicrobiologyDOI: 10.1016/j.tim.2024.07.007

Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE

Braun-Cornejo M, Ornago C, Sonawane V, Haupenthal J, Kany A, Diamanti E, Jézéquel G, Reiling N, Blankenfeldt W, Maas P, Hirsch A (2024)

ACS omegaDOI: 10.1021/acsomega.4c05537

Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes

Chan A, Ho T, Fathoni I, Hamid R, Hirsch A, Saliba K, Leeper F (2024)

RSC Med. Chem. 15 (5): 1773-1781DOI: 10.1039/D4MD00083H

Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes

Chen X, Zhao H, Wang C, Hamed M, Shang Q, Yang Y, Diao X, Sun X, Hu W, Jiang X, …, Wu D, Zhuang J (2024)

Int. J. Antimicrob. Agents 63 (5)DOI: 10.1016/j.ijantimicag.2024.107160

Arg-biodynamers as antibiotic potentiators through interacting with Gram-negative outer membrane lipopolysaccharides

Kamal M, Bassil J, Loretz B, Hirsch A, Lee S, Lehr C (2024)

Eur J Pharm Biopharm 200DOI: 10.1016/j.ejpb.2024.114336

AI is a viable alternative to high throughput screening: a 318-target study

Wallach I, Hirsch, Anna K. H. et al. (2024)

Sci Rep 14 (1)DOI: 10.1038/s41598-024-54655-z

Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain

Gawriljuk V, Godoy A, Oerlemans R, Welker L, Hirsch A, Groves M (2024)

Nat. Commun. 15 (1)DOI: 10.1038/s41467-024-50671-9

Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity

Abdelsamie A, Hamed M, Schütz C, Röhrig T, Kany A, Schmelz S, Blankenfeldt W, Hirsch A, Hartmann R, Empting M (2024)

Eur. J. Med. Chem. 276DOI: 10.1016/j.ejmech.2024.116685

Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms

Osbelt L, Almási É, Wende M, Kienesberger S, Voltz A, Lesker T, Muthukumarasamy U, Knischewski N, Nordmann E, Bielecka A, …, Zechner E, Strowig T (2024)

Nat. Microbiol. 9 (7): 1792-1811DOI: 10.1038/s41564-024-01710-0

Investigation of the Odilorhabdin Biosynthetic Gene Cluster Using NRPS Engineering

Präve L, Seyfert C, Bozhüyük K, Racine E, Müller R, Bode H (2024)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202406389

The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages

Mashayekhi V, Schomisch A, Rasheed S, Aparicio-Puerta E, Risch T, Yildiz D, Koch M, Both S, Ludwig N, Legroux T, …, Hoppstädter J, Kiemer A (2024)

Cell communication and signaling : CCS 22 (1)DOI: 10.1186/s12964-024-01701-y

Mibianto: ultra-efficient online microbiome analysis through k-mer based metagenomics

Hirsch P, Molano L, Engel A, Zentgraf J, Rahmann S, Hannig M, Müller R, Kern F, Keller A, Schmartz G (2024)

Nucleic Acids ResDOI: 10.1093/nar/gkae364

Thermotropic liquid crystals in drug delivery: A versatile carrier for controlled release

Nesterkina M, Kravchenko* I, Hirsch A, Lehr C (2024)

Eur. J. Pharm. Biopharm. 200DOI: 10.1016/j.ejpb.2024.114343

Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy-coupling factor transporters (ECFTs)

Haupenthal J, Rafehi M, Kany A, Lespine A, Stefan K, Hirsch* A, Stefan* S (2024)

Arch. Pharm.DOI: 10.1002/ardp.202400267

Molecular networking and computational NMR analyses uncover six polyketide-terpene hybrids from termite-associated Xylaria isolates

Lee S, Dayras M, Fricke J, Guo H, Balluff S, Schalk F, Yu J, Jeong S, Morgenstern B, Slippers B, Beemelmanns C, Kim K (2024)

Commun Chem 7 (1)DOI: 10.1038/s42004-024-01210-6

Genetic regulation of L-tryptophan metabolism in Psilocybe mexicana supports psilocybin biosynthesis

Seibold P, Dörner S, Fricke J, Schäfer T, Beemelmanns C, Hoffmeister D (2024)

Fungal biology and biotechnology 11 (1)DOI: 10.1186/s40694-024-00173-6

Metabolism and cytotoxicity studies of the two hallucinogens 1cP-LSD and 4-AcO-DET in human liver and zebrafish larvae models using LC-HRMS/MS and a high-content screening assay

Gampfer T, Schütz V, Schippers P, Rasheed S, Baumann J, Wagmann L, Pulver B, Westphal F, Flockerzi V, Müller R, Meyer M (2024)

Journal of pharmaceutical and biomedical analysis 245DOI: 10.1016/j.jpba.2024.116187

Point mutations in the ygiV promoter region lead to cystobactamid resistance and reduced virulence in E. coli

Müller R, Risch T, Kolling D, Mostert D, Seedorf T, Heimann D, Kohnhäuser D, Deschner F, Fries F, Solga D, …, Herrmann J, Sieber S (2024)

BookDOI: 10.21203/rs.3.rs-3751821/v1

Time series of chicken stool metagenomics and egg metabolomics in changing production systems: preliminary insights from a proof-of-concept

Rosch M, Rehner J, Schmartz G, Manier S, Becker U, Müller R, Meyer M, Keller A, Becker S, Keller V (2024)

One health outlook 6 (1)DOI: 10.1186/s42522-024-00100-0

Targeting Intracellular Bacteria with Dual Drug-loaded Lactoferrin Nanoparticles

Andima M, Boese A, Paul P, Koch M, Loretz B, Lehr C (2024)

ACS Infect. Dis.DOI: 10.1021/acsinfecdis.4c00045

Structure Revision of a Widespread Marine Sulfonolipid Class Based on Isolation and Total Synthesis

Roman D, Meisinger P, Guillonneau R, Peng C, Peltner L, Jordan P, Haensch V, Götze S, Werz O, Hertweck C, Chen Y, Beemelmanns C (2024)

Angew. Chem. Int. Ed.: 1433-7851DOI: 10.1002/anie.202401195

Antibiotic resistance and tolerance: What can drug delivery do against this global threat?

Aparicio-Blanco J, Vishwakarma N, Lehr C, Prestidge C, Thomas N, Roberts R, Thorn C, Melero A (2024)

Drug delivery and translational researchDOI: 10.1007/s13346-023-01513-6

Minimum Information for Conducting and Reporting In Vitro Intracellular Infection Assays

Subramaniam S, Joyce P, Ogunniyi A, Dube A, Sampson S, Lehr C, Prestidge C (2024)

ACS Infect. Dis. 10 (2): 337-349DOI: 10.1021/acsinfecdis.3c00613

Drug solubility in biorelevant media in the context of an inhalation-based biopharmaceutics classification system (iBCS)

Floroiu A, Loretz B, Krämer J, Lehr C (2024)

Eur J Pharm Biopharm 197DOI: 10.1016/j.ejpb.2024.114206

Biorelevant subcutaneous in vitro test predicts the release of human and fast acting insulin formulations

Schöner T, Vogel V, Venczel M, Knoth K, Kamm W, Paehler T, Louit G, Terán I, Mundinger P, Marker A, …, Hittinger M, Lehr C (2024)

Int. J. Pharm. 655DOI: 10.1016/j.ijpharm.2024.123995

Isolation of Fidaxomicin and Shunt Metabolites from Actinoplanes deccanensis

Jung E, Hunter M, Dorst A, Major A, Teofilovic T, Müller R, Gademann K (2024)

HCADOI: 10.1002/hlca.202400013

Inhibitory effect of sorangicin A against mutant DNA-dependent RNA polymerase in the obligate intracellular bacterium Chlamydia trachomatis

Li Q, Jansen H, Hansen G, Nurjadi D, Herrmann J, Stadler M, Brönstrup M, Müller R, He C, Graspeuntner S, Rupp J, Shima K (2024)

Int. J. Antimicrob. AgentsDOI: 10.1016/j.ijantimicag.2024.107132

Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity

Al-Saad O, Gabr M, Darwish S, Rullo M, Pisani L, Miniero D, Liuzzi G, Kany A, Hirsch A, Abadi A, …, Catto M, Abdel-Halim M (2024)

European journal of medicinal chemistryDOI: 10.1016/j.ejmech.2024.116266

Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence

Brand M, Ritzmann F, Kattler K, Milasius D, Yao Y, Herr C, Kirsch S, Müller R, Yildiz D, Bals R, Beisswenger C (2024)

Respir. Res. 25 (1)DOI: 10.1186/s12931-023-02636-7

A type III polyketide synthase cluster in the phylum Planctomycetota is involved in alkylresorcinol biosynthesis

Milke L, Kabuu M, Zschoche R, Gätgens J, Krumbach K, Carlstedt K, Wurzbacher C, Balluff S, Beemelmanns C, Jogler C, Marienhagen J, Kallscheuer N (2024)

Appl Microbiol Biotechnol 108 (1)DOI: 10.1007/s00253-024-13065-x

Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor

Sake S, Zhang X, Rajak M, Urbanek-Quaing M, Carpentier A, Gunesch A, Grethe C, Matthaei A, Rückert J, Galloux M, …, Haid* S, Pietschmann* T (2024)

Nat. Commun. 15 (1)DOI: 10.1038/s41467-024-45241-y

High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum

Johannsen S, Gierse R, Krüger A, Edwards R, Nanna V, Fontana A, Di Zhu, Masini T, Carvalho L, Poizat M, …, Wrenger C, Hirsch* A (2024)

ACS Infect. Dis.DOI: 10.1021/acsinfecdis.3c00670

Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT

Exapicheidou I, Shams A, Ibrahim H, Tsarenko A, Backenköhler M, Hamed M, Diamanti E, Volkamer A, slotboom d, Hirsch A (2024)

Chem. Commun. 60 (7): 870-873DOI: 10.1039/D3CC04738E

Nitroxoline resistance is associated with significant fitness loss and diminishes in vivo virulence of Escherichia coli

Deschner F, Risch T, Baier C, Schlüter D, Herrmann J, Müller R (2024)

Microbiology Spectrum 12 (1)DOI: 10.1128/spectrum.03079-23

Is Simultaneous Binding to DNA and Gyrase Important for the Antibacterial Activity of Cystobactamids?

Solga D, Wieske L, Wilcox S, Zeilinger C, Jansen-Olliges L, Cirnski K, Herrmann J, Müller R, Erdelyi M, Kirschning A (2024)

Chem. Eur. J.DOI: 10.1002/chem.202303796

New myxobacteria of the Myxococcaceae clade produce angiolams with antiparasitic activities

Walesch S, Garcia R, Mahmoud A, Panter F, Bollenbach S, Mäser P, Kaiser M, Krug D, Müller R (2024)

Microbiology SpectrumDOI: 10.1128/spectrum.03689-23

Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents

Khalifa H, Rasheed S, Haupenthal J, Herrmann J, Mandour Y, Abadi A, Engel M, Müller R, Hirsch A, Abdel-Halim* M, Hamed* M (2024)

Archiv der PharmazieDOI: 10.1002/ardp.202300656

Mining the microbiota for antibiotics

Beemelmanns C, Keller A, Müller R (2024)

Nat. Microbiol. 9 (1): 13-14DOI: 10.1038/s41564-023-01568-8