Publikationsdatenbank
2021
In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
Groß S, Schnell B, Haack P, Auerbach D, Müller R (2021)
Nat Commun 12 (1)DOI: 10.1038/s41467-021-21848-3
The sandarazols are cryptic and structurally unique plasmid encoded toxins from a rare myxobacterium
Panter F, Bader C, Müller R (2021)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202014671
Front Cover: Phosphonate as a Stable Zinc‐Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH) (ChemMedChem 8/2021)
Voos K, Schönauer E, Alhayek A, Haupenthal J, Andreas A, Müller R, Hartmann R, Brandstetter H, Hirsch A, Ducho C (2021)
ChemMedChem 16 (8): 1198-1198DOI: 10.1002/cmdc.202100229
Hit-optimization using target-directed dynamic combinatorial chemistry: Development of inhibitors of the anti-infective target 1-deoxy-D-xylulose-5-phosphate synthase
Jumde R, Guadigni M, Gierse R, Alhayek A, Di Zhu, Hamid Z, Johannsen S, Elgaher W, Neusens P, Nehls C, …, Reiling N, Hirsch A (2021)
Chemical ScienceDOI: 10.1039/D1SC00330E
miRMaster 2.0: multi-species non-coding RNA sequencing analyses at scale
Fehlmann T, Kern F, Laham O, Backes C, Solomon J, Hirsch P, Volz C, Müller R, Keller A (2021)
Nucleic Acids ResDOI: 10.1093/nar/gkab268
Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity
Ropponen H, Bader C, Diamanti E, Illarionov B, Rottmann M, Fischer M, Witschel M, Müller R, Hirsch A (2021)
ChemMedChemDOI: 10.1002/cmdc.202100067
Synergizing the potential of bacterial genomics and metabolomics to find novel antibiotics
Panter F, Bader C, Müller R (2021)
Chemical ScienceDOI: 10.1039/d0sc06919a
Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection
Mamareli P, Kruse F, Lu C, Guderian M, Floess S, Rox K, Allan D, Carlyle J, Brönstrup M, Müller R, …, Sparwasser T, Lochner M (2021)
Mucosal Immunol. 14 (1): 164-176DOI: 10.1038/s41385-020-0285-7
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis
Almeida L, Dhillon-LaBrooy A, Castro C, Adossa N, Carriche G, Guderian M, Lippens S, Dennerlein S, Hesse C, Lambrecht B, …, Moita L, Sparwasser T (2021)
Immunity 54 (1): 68-83DOI: 10.1016/j.immuni.2020.11.001
A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms
Schütz C, Ho D, Hamed M, Abdelsamie A, Röhrig T, Herr C, Kany A, Rox K, Schmelz S, Siebenbürger L, …, Lehr C, Empting M (2021)
Adv. Sci.DOI: 10.1002/advs.202004369
Stimulation of Probiotic Bacteria Induces Release of Membrane Vesicles with Augmented Anti-inflammatory Activity
Müller L, Kuhn T, Koch M, Fuhrmann G (2021)
ACS Appl. Bio Mater.DOI: 10.1021/acsabm.0c01136
Mastering the Gram-Negative Bacterial Barrier - Chemical Approaches to Increase Bacterial Bioavailability of Antibiotics
Ropponen H, Richter R, Hirsch A, Lehr C (2021)
Advanced Drug Delivery ReviewsDOI: 10.1016/j.addr.2021.02.014
Assessment of the rules related to gaining activity against Gram-negative bacteria
Ropponen H, Diamanti E, Siemens A, Illarionov B, Haupenthal J, Fischer M, Rottmann M, Witschel M, Hirsch A (2021)
RSC Med. Chem.DOI: 10.1039/D0MD00409J
Natural products in drug discovery: advances and opportunities
Atanasov A, Zotchev S, Dirsch V, Supuran C (2021)
Nature reviews. Drug discoveryDOI: 10.1038/s41573-020-00114-z
Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design
Axer A, Jumde R, Adam S, Faust A, Schäfers M, Fobker M, Koehnke J, Hirsch A, Gilmour R (2021)
Chem. Sci. 12 (4): 1286-1294DOI: 10.1039/D0SC04297H
Phosphonate as Stable Zinc-binding Group for Inhibitors of Clostridial Collagenase H (ColH) as Pathoblocker Agents
Voos K, Schönauer E, Alhayek A, Haupenthal J, Andreas A, Müller R, Hartmann R, Brandstetter H, Hirsch A, Ducho C (2021)
ChemMedChemDOI: 10.1002/cmdc.202000994
Expanding the Scope of Detectable Microbial Natural Products by Complementary Analytical Methods and Cultivation Systems
Bader C, Haack P, Panter F, Krug D, Müller R (2021)
Journal of natural productsDOI: 10.1021/acs.jnatprod.0c00942
Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties
Gierse R, Reddem E, Alhayek A, Baitinger D, Hamid Z, Jakobi H, Laber B, Lange G, Hirsch A, Groves (2021)
Biochemical and Biophysical Research Communications 539DOI: 10.1016/j.bbrc.2020.12.069
Kibdelosporangium persicum sp. nov., a new member of the Actinomycetes from a hot desert in Iran
Safaei N, Nouioui I, Mast Y, Zaburannyi N, Rohde M, Schumann P, Müller R, Wink J (2021)
Int J Syst Evol MicrobiolDOI: 10.1099/ijsem.0.004625
2020
Supercritical Fluid Extraction Enhances Discovery of Secondary Metabolites from Myxobacteria
Bader C, Neuber M, Panter F, Krug D, Müller R (2020)
Analytical chemistryDOI: 10.1021/acs.analchem.0c02995
An ambruticin-sensing complex modulates Myxococcus xanthus development and mediates myxobacterial interspecies communication
Marcos-Torres F, Volz C, Müller R (2020)
Nat Commun 11 (1)DOI: 10.1038/s41467-020-19384-7
PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus
Anversa Dimer F, Souza Carvalho-Wodarz C, Goes A, Cirnski K, Herrmann J, Schmitt V, Pätzold L, Abed N, Rossi C, Bischoff M, …, Müller R, Lehr C (2020)
Nanomedicine : nanotechnology, biology, and medicine 24DOI: 10.1016/j.nano.2019.102125
Protein‐Templated Hit Identification via an Ugi Four‐Component Reaction
Mancini F, Unver M, Elgaher W, Jumde V, Alhayek A, Lukat P, Herrmann J, Witte M, Köck M, Blankenfeldt W, Müller R, Hirsch A (2020)
Chem. Eur. J.DOI: 10.1002/chem.202002250
N -Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases
Konstantinovic J, Yahiaoui S, Alhayek A, Haupenthal J, Schönauer E, Andreas A, Kany A, Müller R, Koehnke J, Berger F, …, Brandstetter H, Hirsch A (2020)
J. Med. Chem. 63 (15): 8359-8368DOI: 10.1021/acs.jmedchem.0c00584
SphereCon-a method for precise estimation of residue relative solvent accessible area from limited structural information
Gress A, Kalinina O (2020)
Bioinformatics (Oxford, England) 36 (11): 3372-3378DOI: 10.1093/bioinformatics/btaa159
Probiomimetics-Novel Lactobacillus-Mimicking Microparticles Show Anti-Inflammatory and Barrier-Protecting Effects in Gastrointestinal Models
Kuhn T, Koch M, Fuhrmann G (2020)
Small (Weinheim an der Bergstrasse, Germany) 16 (40)DOI: 10.1002/smll.202003158
Novel PqsR Inverse Agonists
Hamed, M., Ahmed, S. A., Empting. M., Schütz, C., Hartmann, R. W., Röhrig, …, Hirsch, Anna K. H. (2020)
Patent (EP20150119)
Novel PqsR Inverse Agonists
Hamed, M., Ahmed, S. A., Empting. M., Schütz, C., Hartmann, R. W., Röhrig, …, Hirsch, A. K. H. (2020)
Patent (EP20150119)
Streptococcal Extracellular Membrane Vesicles Are Rapidly Internalized by Immune Cells and Alter Their Cytokine Release
Mehanny M, Koch M, Lehr C, Fuhrmann G (2020)
Frontiers in immunology 11DOI: 10.3389/fimmu.2020.00080
Dual-function chromogenic screening-based CRISPR/Cas9 genome editing system for actinomycetes
Wang Q, Xie F, Tong Y, Habisch R, Yang B, Zhang L, Müller R, Fu C (2020)
Applied Microbiology and Biotechnology 104 (1): 225-239DOI: 10.1007/s00253-019-10223-4
Sesbanimide R, a novel cytotoxic polyketide produced by magnetotactic bacteria
Awal R, Haack P, Bader C, Riese C, Schüler D, Müller R (2020)
BookDOI: 10.1101/2020.12.22.424014
Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics
Grandclaudon C, Birudukota N, Elgaher W, Jumde R, Yahiaoui S, Arisetti N, Hennessen F, Hüttel S, Stadler M, Herrmann J, …, Hirsch A, Brönstrup M (2020)
European journal of medicinal chemistry 188DOI: 10.1016/j.ejmech.2019.112005
Discovery of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions via Dynamic Combinatorial Chemistry
Hartman A, Elgaher W, Hertrich N, Andrei S, Ottmann C, Hirsch A (2020)
ACS medicinal chemistry letters 11 (5): 1041-1046DOI: 10.1021/acsmedchemlett.9b00541
Characterization of bromelain indicates a molar excess of inhibitor vs. enzyme molecules, a Jacalin-like lectin and Maillard reaction products
Gross P, Seelert H, Meiser P, Müller R (2020)
Journal of pharmaceutical and biomedical analysis 181DOI: 10.1016/j.jpba.2019.113075
Synthetic and Biological Studies on New Urea and Triazole Containing Cystobactamid Derivatives
Planke T, Cirnski K, Herrmann J, Müller R, Kirschning A (2020)
Chem. Eur. J. 26 (19): 4289-4296DOI: 10.1002/chem.201904073
The glucocorticoid-induced leucine zipper mediates statin-induced muscle damage
Hoppstädter J, Valbuena Perez J, Linnenberger R, Dahlem C, Legroux T, Hecksteden A, Tse W, Flamini S, Andreas A, Herrmann J, …, Bruscoli S, Kiemer A (2020)
FASEB j. 34 (3): 4684-4701DOI: 10.1096/fj.201902557RRR
Myxobacteria-Derived Outer Membrane Vesicles: Potential Applicability Against Intracellular Infections
Goes A, Lapuhs P, Kuhn T, Schulz E, Richter R, Panter F, Dahlem C, Koch M, Garcia R, Kiemer A, Müller R, Fuhrmann G (2020)
Cells 9 (1)DOI: 10.3390/cells9010194
Toxicokinetics and toxicodynamics of the fentanyl homologs cyclopropanoyl-1-benzyl-4´-fluoro-4-anilinopiperidine and furanoyl-1-benzyl-4-anilinopiperidine
Gampfer T, Wagmann L, Park Y, Cannaert A, Herrmann J, Fischmann S, Westphal F, Müller R, Stove C, Meyer M (2020)
Arch. Toxicol. 94 (6): 2009-2025DOI: 10.1007/s00204-020-02726-1
The ROK like protein of Myxococcus xanthus DK1622 acts as a pleiotropic transcriptional regulator for secondary metabolism
Izzat S, Rachid S, Ajdidi A, El-Nakady Y, Liu X, Ye B, Müller R (2020)
J. Biotechnol. 311: 25-34DOI: 10.1016/j.jbiotec.2020.02.005
Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics
Elgaher W, Hamed M, Baumann S, Herrmann J, Siebenbürger L, Krull J, Cirnski K, Kirschning A, Brönstrup M, Müller R, Hartmann R (2020)
Chem. Eur. J. 26 (32): 7219-7225DOI: 10.1002/chem.202000117
Dual-Seq reveals genome and transcriptome of Caedibacter taeniospiralis, obligate endosymbiont of Paramecium
Pirritano M, Zaburannyi N, Grosser K, Gasparoni G, Müller R, Simon M, Schrallhammer M (2020)
Sci. Rep. 10 (1)DOI: 10.1038/s41598-020-65894-1
Thioholgamide A, a New Anti-Proliferative Anti-Tumor Agent, Modulates Macrophage Polarization and Metabolism
Dahlem C, Siow W, Lopatniuk M, Tse W, Kessler S, Kirsch S, Hoppstädter J, Vollmar A, Müller R, Luzhetskyy A, Bartel K, Kiemer A (2020)
Cancers 12 (5)DOI: 10.3390/cancers12051288
Human microbial metabolite mimicry as a strategy to expand the chemical space of potential drugs
Li H, Ranhotra H, Mani S, Dvorák Z, Sokol H, Müller R (2020)
Drug Discov. Today 25 (9): 1575-1579DOI: 10.1016/j.drudis.2020.06.007
ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli
Wallenstein A, Rehm N, Brinkmann M, Selle M, Bossuet-Greif N, Sauer D, Bunk B, Spröer C, Wami H, Homburg S, …, Müller R, Dobrindt U (2020)
mSphere 5 (4)DOI: 10.1128/mSphere.00591-20
Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin
Hennessen F, Miethke M, Zaburannyi N, Loose M, Lukežic T, Bernecker S, Hüttel S, Jansen R, Schmiedel J, Fritzenwanker M, …, Herrmann J, Müller R (2020)
Antibiotics 9 (9)DOI: 10.3390/antibiotics9090619
How to Study the Metabolism of New Psychoactive Substances for the Purpose of Toxicological Screenings-A Follow-Up Study Comparing Pooled Human Liver S9, HepaRG Cells, and Zebrafish Larvae
Wagmann L, Frankenfeld F, Park Y, Herrmann J, Fischmann S, Westphal F, Müller R, Flockerzi V, Meyer M (2020)
Frontiers in chemistry 8DOI: 10.3389/fchem.2020.00539
Natural Products Impacting DNA Methyltransferases and Histone Deacetylases
Akone S, Ntie-Kang F, Stuhldreier F, Ewonkem M, Noah A, Mouelle S, Müller R (2020)
Frontiers in pharmacology 11DOI: 10.3389/fphar.2020.00992
Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus-Based Wound Infection Model in SKH1 Mice
Haupenthal J, Kautz Y, Elgaher W, Pätzold L, Röhrig T, Laschke M, Tschernig T, Hirsch A, Molodtsov V, Murakami K, Hartmann R, Bischoff M (2020)
ACS infectious diseases 6 (10): 2573-2581DOI: 10.1021/acsinfecdis.0c00034
Editorial: Mechanisms of Prokaryotic Predation
Whitworth D, Jurkevitch E, Pérez J, Fuhrmann G, Koval S (2020)
Frontiers in microbiology 11DOI: 10.3389/fmicb.2020.02071
Inhibitors of Pseudomonas aeruginosa virulence factor
Kaya, C., Konstantinovic, J., Voos, K., Walter, I., Kany, A.M., …, Hirsch, Anna K. H. (2020)
Patent (EP20192608.6)
Heterologous expression of the atypical tetracycline chelocardin reveals the full set of genes required for its biosynthesis
Lukežic T, Pikl Š, Zaburannyi N, Remškar M, Petkovic H, Müller R (2020)
Microb. Cell Fact. 19 (1)DOI: 10.1186/s12934-020-01495-x
Frontispiece: Protein‐Templated Hit Identification through an Ugi Four‐Component Reaction
Federica Mancini, M. Yagiz Unver, Walid A. M. Elgaher, Varsha R. Jumde, Alaa Alhayek, Peer Lukat, Jennifer Herrmann, Martin D. Witte, Matthias Köck, Wulf Blankenfeldt, Rolf Müller, Hirsch A (2020)
Chemistry – A European Journal 26 (64)DOI: 10.1002/chem.202086462
Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections
Schiefer A, Hübner M, Krome A, Lämmer C, Ehrens A, Aden T, Koschel M, Neufeld H, Chaverra-Muñoz L, Jansen R, …, Pfarr K, Hoerauf A (2020)
PLoS Negl. Trop. Dis. 14 (12)DOI: 10.1371/journal.pntd.0008930
Leben und Überleben im Boden: Myxococcus xanthus ist Mikrobe des Jahres 2020
Volz C, Krug D, Müller R (2020)
Biol. Unserer Zeit 50 (6): 424-432DOI: 10.1002/biuz.202010721
The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase
Lilic M, Chen J, Boyaci H, Braffman N, Hubin E, Herrmann J, Müller R, Mooney R, Landick R, Darst S, Campbell E (2020)
Proc. Natl. Acad. Sci. U.S.A.DOI: 10.1073/pnas.2013706117
Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry
Cirnski K, Coetzee J, Herrmann J, Müller R (2020)
J. Vis. Exp. (164)DOI: 10.3791/61703
A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria
Richter R, Kamal M, García-Rivera M, Kaspar J, Junk M, Elgaher W, Srikakulam S, Gress A, Beckmann A, Grißmer A, …, Schneider-Daum N, Lehr C (2020)
Materials Today BioDOI: 10.1016/j.mtbio.2020.100084
Protein-observed 19F NMR of LecA from Pseudomonas aeruginosa
Shanina E, Siebs E, Zhang H, Silva D, Joachim I, Titz A, Rademacher C (2020)
GlycobiologyDOI: 10.1093/glycob/cwaa057
Directing Drugs to Bugs: Antibiotic-Carbohydrate Conjugates Targeting Biofilm-Associated Lectins of Pseudomonas aeruginosa
Meiers J, Zahorska E, Röhrig T, Hauck D, Wagner S, Titz A (2020)
Journal of medicinal chemistry 63 (20): 11707-11724DOI: 10.1021/acs.jmedchem.0c00856
Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection
Xabier Murgia, Andreas M. Kany, Christian Herr, Duy-Khiet Ho, Chiara De Rossi, Robert Bals, Claus-Michael Lehr, Hirsch A, Rolf W. Hartmann, Martin Empting, Teresa Röhrig (2020)
Sci Rep 10 (1): 1-8DOI: 10.1038/s41598-020-73459-5
An extended catalogue of tandem alternative splice sites in human tissue transcriptomes
Mironov A, Denisov S, Gress A, Kalinina O, Pervouchine D (2020)
BookDOI: 10.1101/2020.09.11.292722
The bottromycin epimerase BotH defines a group of atypical α/β-hydrolase-fold enzymes
Sikandar A, Franz L, Adam S, Santos-Aberturas J, Horbal L, Luzhetskyy A, Truman A, Kalinina O, Koehnke J (2020)
Nat Chem Biol 16 (9): 1013-1018DOI: 10.1038/s41589-020-0569-y
DIGGER: exploring the functional role of alternative splicing in protein interactions
Louadi Z, Yuan K, Gress A, Tsoy O, Kalinina O, Baumbach J, Kacprowski T, List M (2020)
Nucleic Acids ResDOI: 10.1093/nar/gkaa768
Frequent subgraph mining for biologically meaningful structural motifs
Keller S, Miettinen P, Kalinina O (2020)
BookDOI: 10.1101/2020.05.14.095695
Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model
Park Y, Meyer M, Müller R, Herrmann J (2020)
Molecules 25 (19)DOI: 10.3390/molecules25194474
2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene-Nucleoside
Okoth D, Hug J, Garcia R, Spröer C, Overmann J, Müller R (2020)
Molecules (Basel, Switzerland) 25 (11)DOI: 10.3390/molecules25112676
Biosynthesis of Cittilins, Unusual Ribosomally Synthesized and Post-translationally Modified Peptides from Myxococcus xanthus
Hug J, Dastbaz J, Adam S, Revermann O, Koehnke J, Krug D, Müller R (2020)
ACS chemical biology 15 (8): 2221-2231DOI: 10.1021/acschembio.0c00430
7-Hydroxycoumarins are Affinity-based Fluorescent Probes for Competitive Binding Studies of Macrophage Migration Inhibitory Factor
Xiao Z, Chen D, Song S, van der Vlag R, van der Wouden P, van Merkerk R, Cool R, Hirsch A, Melgert B, Quax W, Poelarends G, Dekker F (2020)
Journal of medicinal chemistryDOI: 10.1021/acs.jmedchem.0c01160
Polymer-Cargo-Complexes compremising cross-linked copolymers and cargo molecules
Lee S, Loretz B, Lehr C, Hirsch A (2020)
Patent
N-Aryl Mercaptopropionamides as inhibitors of Metallo-ß-Lactamases
Yahiaoui, S., Kaya, C., Kany, A. M., Haupenthal, J., Wichelhaus, T., …, Hirsch, Anna K. H. (2020)
Patent (EP20164855.7)
Advancing human in vitro pulmonary disease models in preclinical research: opportunities for lung-on-chips
Artzy-Schnirman A, Lehr C, Sznitman J (2020)
Expert Opinion on Drug Delivery 17 (5): 621-625DOI: 10.1080/17425247.2020.1738380
Design and in vitro characterization of multistage silicon-PLGA budesonide particles for inflammatory bowel disease
Leonard F, Srinivasan S, Liu X, Collnot E, Ferrari M, Lehr C, Godin B (2020)
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 151: 61-72DOI: 10.1016/j.ejpb.2020.03.020
P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives
Montefusco-Pereira C, Horstmann J, Ebensen T, Beisswenger C, Bals R, Guzmán C, Schneider-Daum N, Carvalho-Wodarz C, Lehr C (2020)
Journal of visualized experiments : JoVE (160)DOI: 10.3791/61069
Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections
Ho D, Murgia X, Rossi C, Christmann R, Hüfner de Mello Martins A, Koch M, Andreas A, Herrmann J, Müller R, Empting M, …, Couvreur P, Lehr C (2020)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202001407
Itaconic Acid Increases the Efficacy of Tobramycin against Pseudomonas aeruginosa Biofilms
Ho D, Rossi C, Loretz B, Murgia X, Lehr C (2020)
Pharmaceutics 12 (8)DOI: 10.3390/pharmaceutics12080691
Nanoparticle Targeting to Scalp Hair Follicles: New Perspectives for a Topical Therapy for Alopecia Areata
Christmann R, Thomas C, Jager N, Raber A, Loretz B, Schaefer U, Tschernig T, Vogt T, Lehr C (2020)
The Journal of investigative dermatology 140 (1): 243-246DOI: 10.1016/j.jid.2019.05.028
pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers
Lee S, Kaya C, Jang H, Koch M, Loretz B, Buhler E, Lehr C, Hirsch A (2020)
Mater. Chem. Front. 4 (3): 905-909DOI: 10.1039/C9QM00651F
Safety assessment of excipients (SAFE) for orally inhaled drug products
Metz J, Scharnowske L, Hans F, Schnur S, Knoth K, Zimmer H, Limberger M, Groß H, Lehr C, Hittinger M (2020)
ALTEX 37 (2): 275-286DOI: 10.14573/altex.1910231
3D air-liquid interface culture of Cystic Fibrosis bronchial epithelia, macrophages and P. aeruginosa to assess host-pathogen interaction and drug efficacy
Montefusco C, Montefusco-Pereira C (2020)
BookDOI: 10.22028/D291-31815
Inhalationstoxizität von Nanopartikeln // The role of alveolar macrophages in biokinetics and biological effects of inhaled nanoparticles
Koltermann-Jülly J (2020)
BookDOI: 10.22028/D291-31034
Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach
Markella Konstantinidou, Francesca Magari, Fandi Sutanto, Jörg Haupenthal, Varsha R. Jumde, M. Yagiz Ünver, Andreas Heine, Carlos Jamie Camacho, Hirsch A, Gerhard Klebe, Alexander Dömling (2020)
ChemMedChem 15 (8): 680-684DOI: 10.1002/cmdc.202000024
Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling
Hollenhorst M, Jurastow I, Nandigama R, Appenzeller S, Li L, Vogel J, Wiederhold S, Althaus M, Empting M, Altmüller J, …, Saliba A, Krasteva-Christ G (2020)
FASEB j. 34 (1): 316-332DOI: 10.1096/fj.201901314RR
Optimized Inhibitors of MDM2 via an Attempted Protein‐Templated Reductive Amination
Vlag R, Yagiz Unver M, Felicetti T, Twarda-Clapa A, Kassim F, Ermis C, Neochoritis C, Musielak B, Labuzek B, Dömling A, Holak T, Hirsch A (2020)
ChemMedChem 15 (4): 370-375DOI: 10.1002/cmdc.201900574
BOPC1 Enantiomers Preparation and HuR Interaction Study. From Molecular Modeling to a Curious DEEP-STD NMR Application
Della Volpe S, Listro R, Parafioriti M, Di Giacomo M, Rossi D, Ambrosio F, Costa G, Alcaro S, Ortuso F, Hirsch A, Vasile F, Collina S (2020)
ACS medicinal chemistry letters 11 (5): 883-888DOI: 10.1021/acsmedchemlett.9b00659
Validating the 1,2-Difluoro Motif As a Hybrid Bioisostere of CF3 and Et Using Matrix Metalloproteinases As Structural Probes
Erdeljac N, Thiehoff C, Jumde R, Daniliuc C, Höppner S, Faust A, Hirsch A, Gilmour R (2020)
Journal of medicinal chemistry 63 (11): 6225-6237DOI: 10.1021/acs.jmedchem.0c00648
Synthesis and Biological Evaluation of Novel 2-Substituted Analogues of (–)-Pentenomycin I
Zisopoulou S, Bousis S, Haupenthal J, Herrmann J, Müller R, Hirsch A, Komiotis D, Gallos J, Stathakis C (2020)
Synlett 31 (05): 475-481DOI: 10.1055/s-0039-1690772
Discovery of Antibacterial Agents Inhibiting the Energy-Coupling Factor (ECF) Transporters by Structure-Based Virtual Screening
Diamanti E, Setyawati I, Bousis S, mojas l, Swier l, Haupenthal J, Gibson P, Volz C, stanek w, Jaeger m, …, slotboom d, Hirsch A (2020)
BookDOI: 10.26434/chemrxiv.11728710.v1
Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement
Zielinska A, Savietto A, Sousa Borges A, Martinez D, Berbon M, Roelofsen J, Hartman A, Boer R, van der Klei I, Hirsch A, …, Bramkamp M, Scheffers D (2020)
eLife 9DOI: 10.7554/eLife.57179
Potential Dental Biofilm Inhibitors: Dynamic Combinatorial Chemistry Affords Sugar-Based Molecules that Target Bacterial Glucosyltransferase
Hartman A, Jumde V, Elgaher W, Te Poele E, Dijkhuizen L, Hirsch A (2020)
ChemMedChemDOI: 10.1002/cmdc.202000222
A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d -galactose pentaacetate
Zahorska E, Kuhaudomlarp S, Minervini S, Yousaf S, Lepsik M, Kinsinger T, Hirsch A, Imberty A, Titz A (2020)
Chem. Commun. 56 (62): 8822-8825DOI: 10.1039/d0cc03490h
Hit-Optimization Using Target-Directed Dynamic Combinatorial Chemistry: Development of Inhibitors of the Anti-Infective Target 1-Deoxy-D-Xylulose-5-Phosphate Synthase
Jumde R, Guardigni M, Gierse R, Alhayek A, Zhu D, Hamed Z, Johannsen S, Elgaher W, Haupenthal J, Hirsch A (2020)
BookDOI: 10.26434/chemrxiv.12681761.v1
Resistance-associated substitutions in patients with chronic hepatitis C virus genotype 4 infection
Dietz J, Kalinina O, Vermehren J, Peiffer K, Matschenz K, Buggisch P, Niederau C, Schattenberg J, Müllhaupt B, Yerly S, …, Welsch C, Sarrazin C (2020)
J. Viral Hepat.DOI: 10.1111/jvh.13322.
Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors
Bastys T, Gapsys V, Walter H, Heger E, Doncheva N, Kaiser R, Groot B, Kalinina O (2020)
Retrovirology 17 (1)DOI: 10.1186/s12977-020-00520-6
A shift of dynamic equilibrium between the KIT active and inactive states causes drug resistance
Srikakulam S, Bastys T, Kalinina O (2020)
ProteinsDOI: 10.1002/prot.25963
Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy
Testolin G, Cirnski K, Rox K, Prochnow H, Fetz V, Grandclaudon C, Mollner T, Baiyoumy A, Ritter A, Leitner C, …, Müller R, Brönstrup M (2020)
Chemical Science 11 (5): 1316-1334DOI: 10.1039/C9SC04769G
Restriction-Free Construction of a Phage-Presented Very Short Macrocyclic Peptide Library
Jakob V, Helmsing S, Hust M, Empting M (2020)
Methods in molecular biology (Clifton, N.J.) 2070: 95-113DOI: 10.1007/978-1-4939-9853-1_6
Discovery of Novel Latency-Associated Nuclear Antigen Inhibitors as Antiviral Agents Against Kaposi's Sarcoma-Associated Herpesvirus
Kirsch P, Jakob V, Elgaher W, Walt C, Oberhausen K, Schulz T, Empting M (2020)
ACS chemical biology 15 (2): 388-395DOI: 10.1021/acschembio.9b00845
New PqsR Inverse Agonists
Schütz, C., Emmpting, M., Ahmed, A., Hamed, M., Hartmann, R. W., …, Hirsch, Anna K. H. (2020)
Patent (EP 20150104.6-1110)
Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility
Montefusco-Pereira C, Formicola B, Goes A, Re F, Marrano C, Mantegazza F, Carvalho-Wodarz C, Fuhrmann G, Caneva E, Nicotra F, Lehr C, Russo L (2020)
European Journal of Pharmaceutics and Biopharmaceutics 149: 12-20DOI: 10.1016/j.ejpb.2020.01.013
Diffusion and transport of extracellular vesicles
Fuhrmann G (2020)
Nature Nanotechnology 15 (3): 168-169DOI: 10.1038/s41565-020-0651-3
Liver-derived extracellular vesicles: A cell by cell overview to isolation and characterization practices
Zivko C, Fuhrmann G, Luciani P (2020)
Biochimica et Biophysica Acta - General Subjects 1865 (4)DOI: 10.1016/j.bbagen.2020.129559
Expression, Purification, and Functional Characterization of Tectonin 2 from Laccaria bicolor: A Six-Bladed Beta-Propeller Lectin Specific for O-Methylated Glycans
Wohlschlager T, Titz A, Künzler M, Varrot A (2020)
Methods Mol Biol 2132: 669-682DOI: 10.1007/978-1-0716-0430-4_58
Bacteria as genetically programmable producers of bioactive natural products
Hug J, Krug D, Müller R (2020)
Nat. rev. chem. 4 (4): 172-193DOI: 10.1038/s41570-020-0176-1
Host Development for Heterologous Expression and Biosynthetic Studies of Myxobacterial Natural Products
Hug J, Müller R (2020)
In pressDOI: 10.1016/B978-0-12-409547-2.14818-8
Myxobakterielle Naturstofffabriken
Krug D, Garcia R, Müller R (2020)
Biospektrum 26 (1): 32-36DOI: 10.1007/s12268-020-1334-1
Hot EVs – how temperature affects extracellular vesicles
Schulz E, Karagianni A, Koch M, Fuhrmann G (2020)
European Journal of Pharmaceutics and Biopharmaceutics 146: 55-63DOI: 10.1016/j.ejpb.2019.11.010
In depth natural product discovery - Myxobacterial strains that provided multiple secondary metabolites
Bader C, Panter F, Müller R (2020)
Biotechnol Adv. 39DOI: 10.1016/j.biotechadv.2019.107480