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Researchers in HIPS Laboratory

Publications

Publication Highlights

Have a look at our latest discoveries.


Publication database

2025

Unlocking the Antiviral Arsenal: Structure-Guided Optimization of Small-Molecule Inhibitors against RSV and hCoV-229E

Karhan C, Sake S, Gunesch A, Grethe C, Hellwinkel B, Köhler N, Kiefer A, Hapko U, Kany A, Pietschmann T, Hirsch A (2025)

European journal of medicinal chemistryDOI: 10.1016/j.ejmech.2025.117282

The fungal natural product class of the sorbicillinoids: structures, bioactivities, biosynthesis, and synthesis

Milzarek T, Gulder T (2025)

Nat. Prod. Rep.DOI: 10.1039/d4np00059e

PEARL: Protein Eluting Alginate with Recombinant Lactobacilli

Tadimarri V, Blanch-Asensio M, Deshpande K, Baumann J, Baumann C, Müller R, Trujillo S, Sankaran S (2025)

Small (Weinheim an der Bergstrasse, Germany)DOI: 10.1002/smll.202408316

Uncovering the genetic basis of antiviral polyketide limocrocin biosynthesis through heterologous expression

Melnyk S, Stierhof M, Bratiichuk D, Fries F, Müller R, Rebets Y, Luzhetskyy A, Ostash B (2025)

Microb. Cell Fact. 24 (1)DOI: 10.1186/s12934-024-02621-9

Targeting IspD for Anti-infective and Herbicide Development: Exploring Its Role, Mechanism, and Structural Insights

Willocx D, Diamanti E, Hirsch A (2025)

Journal of medicinal chemistryDOI: 10.1021/acs.jmedchem.4c01146

Apo structure of Mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate synthase DXPS: Dynamics and implications for inhibitor design

Gawriljuk V, Alhayek A, Hirsch A, Groves M (2025)

Biochemical and Biophysical Research Communications 747DOI: 10.1016/j.bbrc.2024.151246

The PLSDB 2025 update: enhanced annotations and improved functionality for comprehensive plasmid research

Molano L, Hirsch P, Hannig M, Müller R, Keller A (2025)

Nucleic Acids Res 53 (D1): 189-DOI: 10.1093/nar/gkae1095

2024

High-Affinity Lectin Ligands Enable the Detection of Pathogenic Pseudomonas aeruginosa Biofilms: Implications for Diagnostics and Therapy

Zahorska E, Denig L, Lienenklaus S, Kuhaudomlarp S, Tschernig T, Lipp P, Munder A, Gillon E, Minervini S, Verkhova V, …, Wagner S, Titz A (2024)

JACS Au 4 (12): 4715-4728DOI: 10.1021/jacsau.4c00670

A fucose-binding superlectin from Enterobacter cloacae with high Lewis and ABO blood group antigen specificity

Beshr G, Sikandar A, Gläser J, Fares M, Sommer R, Wagner S, Köhnke J, Titz A (2024)

J. Biol. Chem.DOI: 10.1016/j.jbc.2024.108151

Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD

Willocx D, D'Auria L, Walsh D, Scherer H, Alhayek A, Hamed M, Borel F, Diamanti E, Hirsch A (2024)

Angew. Chem., Int. Ed. Engl.DOI: 10.1002/anie.202414615

Targeting Plasmodium falciparum IspD in the Methyl-d-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity

Willocx D, Bizzarri L, Alhayek A, Kannan D, Bravo P, Illarionov B, Rox K, Lohse J, Fischer M, Kany A, …, Diamanti E, Hirsch A (2024)

Journal of medicinal chemistry 67 (19): 17070-17086DOI: 10.1021/acs.jmedchem.4c00212

Autologous DNA mobilization and multiplication expedite natural products discovery from bacteria

Xie F, Zhao H, Liu J, Yang X, Neuber M, Agrawal A, Kaur A, Herrmann J, Kalinina O, Wei X, Müller R, Fu C (2024)

Science 386 (6727)DOI: 10.1126/science.abq7333

A New Class of Polyion Complex Vesicles (PIC-somes) to Improve Antimicrobial Activity of Tobramycin in Pseudomonas Aeruginosa Biofilms

Yildirim T, Bali A, Koch M, Paul P, Latta L, Schneider-Daum N, Gallei M, Lehr C (2024)

Small (Weinheim an der Bergstrasse, Germany) 20 (40)DOI: 10.1002/smll.202401926

Decoding the diagnostic and therapeutic potential of microbiota using pan-body pan-disease microbiomics

Schmartz G, Rehner J, Gund M, Keller V, Molano L, Rupf S, Hannig M, Berger T, Flockerzi E, Seitz B, …, Bals R, Keller A (2024)

Nat Commun 15 (1)DOI: 10.1038/s41467-024-52598-7

A Novel 3D Printed Model of Infected Human Hair Follicles to Demonstrate Targeted Delivery of Nanoantibiotics

Aliyazdi S, Frisch S, Neu T, Veldung B, Karande P, Schaefer U, Loretz B, Vogt T, Lehr C (2024)

ACS biomaterials science & engineering 10 (8): 4947-4957DOI: 10.1021/acsbiomaterials.4c00570

Discovery of the Pendulisporaceae: An extremotolerant myxobacterial family with distinct sporulation behavior and prolific specialized metabolism

Garcia R, Popoff A, Bader C, Löhr J, Walesch S, Walt C, Boldt J, Bunk B, Haeckl F, Gunesch A, …, Bach T, Müller R (2024)

Chem 10: 1-20DOI: 10.1016/j.chempr.2024.04.019

Dual inhibitors of Pseudomonas aeruginosa virulence factors LecA and LasB

Metelkina O, Konstantinovic J, Klein A, Shafiei R, Fares M, Alhayek A, Yahiaoui S, Elgaher W, Haupenthal J, Titz* A, Hirsch* A (2024)

Chem. Sci. 15DOI: 10.1039/D4SC02703E

Identification by Synthesis: Imidacins, Urocanate-Derived Alkaloids from the Myxobacterium Stigmatella aurantiaca

Kostka M, Krug D, Herrmann J, Dickschat J, Meyer J, Müller R, Schulz S (2024)

Org. Lett.DOI: 10.1021/acs.orglett.4c02036

SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination

Iram T, Garcia M, Amand J, Kaur A, Atkins M, Iyer M, Lam M, Ambiel N, Jorgens D, Keller A, …, Kern F, Zuchero J (2024)

Proc. Natl. Acad. Sci. U.S.A. 121 (12)DOI: 10.1073/pnas.2307250121

The Peptide Antibiotic Corramycin Adopts a β-Hairpin-like Structure and Is Inactivated by the Kinase ComG

Adam S, Fries F, Tesmar A, Rasheed S, Deckarm S, Sousa C, Reberšek R, Risch T, Mancini S, Herrmann J, …, Kalinina O, Müller R (2024)

J. Am. Chem. Soc.DOI: 10.1021/jacs.3c13208

ZEBRA: a hierarchically integrated gene expression atlas of the murine and human brain at single-cell resolution

Flotho M, Amand J, Hirsch P, Grandke F, Wyss-Coray T, Keller A, Kern F (2024)

Nucleic Acids Res 52 (D1): 1089-DOI: 10.1093/nar/gkad990

Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins

Fu C, Liu Y, Walt C, Rasheed S, Bader C, Lukat P, Neuber M, Haeckl F, Blankenfeldt W, Kalinina O, Müller R (2024)

Nat Commun 15 (1)DOI: 10.1038/s41467-024-44953-5

The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity

Kalkreuter E, Kautsar S, Yang D, Bader C, Teijaro C, Fluegel L, Davis C, Simpson J, Lauterbach L, Steele A, …, Carvalho L, Shen B (2024)

bioRxivDOI: 10.1101/2023.12.14.571759

Evolution-inspired engineering of nonribosomal peptide synthetases

Bozhüyük K, Präve L, Kegler C, Schenk L, Kaiser S, Schelhas C, Shi Y, Kuttenlochner W, Schreiber M, Kandler J, …, Hochberg G, Bode H (2024)

Science 383 (6689)DOI: 10.1126/science.adg4320

Behavioral and electrophysiological responses of the male medfly, Ceratitis capitata, to thymol and carvacrol ethers

Tabanca N, Cloonan K, Nesterkina M, Gill M, Montgomery W, Kravchenko I, Kendra P (2024)

Pest management scienceDOI: 10.1002/ps.8324

Synthesis and Structure of a Coordination Polymer of Ni(II) with 2-(4-Bromophenoxy)acetohydrazide

Martsynko ?, Nesterkina M, Finik ?, Tsymbaliuk K, Dyakonenko V, Shishkina S, Kravchenko I (2024)

Molbank 2024 (2)DOI: 10.3390/M1819

Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes

Geißler A, Junca H, Kany A, Daumann L, Hirsch A, Pieper D, Sieber S (2024)

Chem. Sci. 15 (30): 11946-11955DOI: 10.1039/D4SC01940G

Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery**

Afanasenko A, Wu X, Santi A, Elgaher W, Kany A, Shafiei R, Schulze M, Schulz T, Haupenthal J, Hirsch A, Barta K (2024)

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 136 (4)DOI: 10.1002/ange.202308131

Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity

Mielniczuk S, Hoff K, Baselious F, Li Y, Haupenthal J, Kany A, Riedner M, Rohde H, Rox K, Hirsch A, …, Sippl W, Holl R (2024)

Journal of medicinal chemistry 67 (19): 17363-17391DOI: 10.1021/acs.jmedchem.4c01262

Spray drying of a zinc complexing agent for inhalation therapy of pulmonary fibrosis

Stella J, Abdelaal M, Kamal M, Shehu K, Alhayek A, Haupenthal J, Hirsch A, Schneider M (2024)

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 202DOI: 10.1016/j.ejps.2024.106891

Journal of Medicinal Chemistry Collection: Drug Discovery in Germany

Laufer S, Gehringer M, Titz A (2024)

Journal of medicinal chemistry 67 (4)DOI: 10.1021/acs.jmedchem.4c00122

Glycomimetics as Candidates for Treatment and Prevention of Catheter-associated Biofilms Formed by Pseudomonas aeruginosa

Vogel C, Rox K, Wagenlehner F, Titz A (2024)

European urology focus 10 (5): 720-721DOI: 10.1016/j.euf.2024.08.011

Synthetic studies on the tetrasubstituted D-ring of cystobactamids lead to potent terephthalic acid antibiotics

Stappert M, Kohnhäuser D, Seedorf T, Coetzee J, Rox K, Fuchs H, Cirnski K, Leitner C, Herrmann J, Kirschning A, Müller R, Brönstrup M (2024)

Commun Chem 7 (1)DOI: 10.1038/s42004-024-01337-6

Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens

Fenwick M, Pierce P, Abendroth J, Barrett K, Barrett L, Bowatte K, Choi R, Chun I, Conrady D, Craig J, …, Edwards T, Myler P (2024)

Communications Biology 7 (1)DOI: 10.1038/s42003-024-07175-5

Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model

Kiefer A, Schütz C, Englisch C, Kolling D, Speicher S, Kany A, Shafiei R, Wadood N, Aljohmani A, Wirschem N, …, Haupenthal J, Hirsch A (2024)

DOI: 10.26434/chemrxiv-2024-3mtxb

In Vivo Activity Profiling of Biosynthetic Darobactin D22 against Critical Gram-Negative Pathogens

Kany A, Fries F, Seyfert C, Porten C, Deckarm S, Chacón Ortiz M, Dubarry N, Vaddi S, Große M, Bernecker S, …, Herrmann J, Müller R (2024)

ACS Infect. Dis. 10 (12): 4337-4346DOI: 10.1021/acsinfecdis.4c00687

IspE kinase as an anti-infective target: Role of a hydrophobic pocket in inhibitor binding

Hamid R, Walsh D, Diamanti E, Aguilar D, Lacour A, Hamed M, Hirsch A (2024)

Structure (London, England : 1993) 32 (12): 2390-2398DOI: 10.1016/j.str.2024.10.009

Targeting the Plasmodium falciparum IspE Enzyme

Diamanti E, Steinbach A, Carvalho L, Ropponen H, Lacour A, Hamid R, Eisa S, Bravo P, Bousis S, Illarionov B, …, Sieber S, Hirsch A (2024)

ACS omega 9 (44): 44465-44473DOI: 10.1021/acsomega.4c06038

Expression and characterization of pantothenate energy-coupling factor transporters as an anti-infective drug target

Shams A, Bousis S, Diamanti E, Elgaher W, Zeimetz L, Haupenthal J, slotboom d, Hirsch A (2024)

Protein Sci. 33 (11)DOI: 10.1002/pro.5195

Studying Target-Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry

Bizzarri L, Steinbrunn D, Quennesson T, Lacour A, Bianchino G, Bravo P, Chaignon P, Lohse J, Mäser P, Seemann M, …, Hirsch A, Hahne H (2024)

ACS Infect. Dis. 10 (12): 4087-4102DOI: 10.1021/acsinfecdis.4c00417

Integral Solvent-Induced Protein Precipitation for Target-Engagement Studies in Plasmodium falciparum

Bravo P, Bizzarri L, Steinbrunn D, Lohse J, Hirsch A, Mäser P, Rottmann M, Hahne H (2024)

ACS Infect. Dis. 10 (12): 4073-4086DOI: 10.1021/acsinfecdis.4c00418

Dynamic Combinatorial Chemistry Unveils Nsp10 Inhibitors with Antiviral Potential Against SARS-CoV-2

Jumde R, Jézéquel G, Saramago M, Frank N, Adam S, Cunha M, Bader C, Gunesch A, Köhler N, Johannsen S, …, Arraiano C, Hirsch A (2024)

Chem. - Eur. J.DOI: 10.1002/chem.202403390

Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery

Liu Y, Hamm T, Eichinger T, Kamm W, Wieland H, Loretz B, Hirsch A, Lee S, Lehr C (2024)

Int. J. Nanomedicine 19: 4429-4449DOI: 10.2147/IJN.S448578

A stretchable human lung‐on‐chip model of alveolar inflammation for evaluating anti‐inflammatory drug response

Richter C, Latta L, Harig D, Carius P, Stucki J, Hobi N, Hugi A, Schumacher P, Krebs T, Gamrekeli A, …, Schneider-Daum N, Lehr C (2024)

Bioengineering & Transla MedDOI: 10.1002/btm2.10715

Design and evaluation of nanostructured lipid carrier of Bergenin isolated from Pentaclethra macrophylla for anti-inflammatory effect on lipopolysaccharide-induced inflammatory responses in macrophages

Nnamani P, Nwagwu C, Diovu E, Abonyi O, Nesterkina M, Neu T, Richter C, Loretz B, Lehr C (2024)

Eur J Pharm Biopharm 200DOI: 10.1016/j.ejpb.2024.114307

Biopolymeric and lipid-based nanotechnological strategies for the design and development of novel mosquito repellent systems: recent advances

Nwagwu C, Onugwu A, Echezona A, Uzondu S, Agbo C, Kenechukwu F, Ogbonna J, Ugorji L, Nwobi L, Nwobi O, …, Lehr C, Attama A (2024)

Nanoscale advances 6 (19): 4751-80DOI: 10.1039/d4na00474d

Identification of inhibitors targeting the energy-coupling factor (ECF) transporters

Diamanti E, Souza P, Setyawati I, Bousis S, Monjas L, Swier L, Shams A, Tsarenko A, Stanek W, Jäger M, …, slotboom d, Hirsch A (2024)

Communications Biology 7 (1)DOI: 10.1038/s42003-024-05770-0

Thermo-amplifier circuit in probiotic E. coli for stringently temperature-controlled release of a novel antibiotic

Dey S, Seyfert C, Fink-Straube C, Kany A, Müller R, Sankaran S (2024)

Journal of biological engineering 18 (1)DOI: 10.1186/s13036-024-00463-y

Olikomycin A-A Novel Calcium-Dependent Lipopeptide with Antibiotic Activity Against Multidrug-Resistant Bacteria

Makitrynskyy R, Keller L, Kaur A, Tsypik O, Munz L, Bechthold A, Müller R (2024)

Chem. Eur. J.DOI: 10.1002/chem.202403985

Structure Revision of Halisphingosine A via Total Synthesis and Bioactivity Studies

Sauer M, Kany A, Götze S, Müller R, Beemelmanns C (2024)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202416036

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

Zdouc M, Blin K, Louwen N, Navarro J, Loureiro C, Bader C, Bailey C, Barra L, Booth T, Bozhüyük K, …, Weber T, Medema M (2024)

Nucleic Acids Res. Spec. Publ.DOI: 10.1093/nar/gkae1115

Realizing time-staggered expression of nucleic acid-encoded proteins by co-delivery of messenger RNA and plasmid DNA on a single nanocarrier

Nasr S, Paul P, Loretz B, Lehr C (2024)

Drug delivery and translational research 14 (12): 3339-3353DOI: 10.1007/s13346-024-01668-w

Harnessing Gram-negative bacteria for novel anti-Gram-negative antibiotics

Birkelbach J, Seyfert C, Walesch S, Müller R (2024)

Microbial Biotechnology 17 (11)DOI: 10.1111/1751-7915.70032

Comparative genomics unravels a rich set of biosynthetic gene clusters with distinct evolutionary trajectories across fungal species (Termitomyces) farmed by termites

Schmidt S, Murphy R, Vizueta J, Schierbech S, Conlon B, Kreuzenbeck N, Vreeburg S, van de Peppel L, Aanen D, Silué K, …, Weber T, Poulsen M (2024)

Commun Biol 7 (1)DOI: 10.1038/s42003-024-06887-y

Antimicrobial and antibiotic-potentiating effect of calcium peroxide nanoparticles on oral bacterial biofilms

Bankar N, Latta L, Loretz B, Reda B, Dudek J, Hähl H, Hannig M, Lehr C (2024)

npj Biofilms and Microbiomes 10 (1)DOI: 10.1038/s41522-024-00569-7

Interaction of the Atypical Tetracyclines Chelocardin and Amidochelocardin with Renal Drug Transporters

Rox K, Kühne A, Herrmann J, Jansen R, Hüttel S, Bernecker S, Hagos Y, Brönstrup M, Stadler M, Hesterkamp T, Müller R (2024)

ACS Pharmacol. Transl. Sci. 7 (7): 2093-2109DOI: 10.1021/acsptsci.4c00183

Bacteria from the Amycolatopsis genus associated with a toxic bird secrete protective secondary metabolites

Seibel E, Um S, Bodawatta K, Komor A, Decker T, Fricke J, Murphy R, Maiah G, Iova B, Maus H, …, Poulsen M, Beemelmanns C (2024)

Nat Commun 15 (1)DOI: 10.1038/s41467-024-52316-3

Statistical analysis of feature-based molecular networking results from non-targeted metabolomics data

Pakkir Shah A, Walter A, Ottosson F, Russo F, Navarro-Diaz M, Boldt J, Kalinski J, Kontou E, Elofson J, Polyzois A, …, Ernst M, Petras D (2024)

Nature protocolsDOI: 10.1038/s41596-024-01046-3

Optimization of the Central α-Amino Acid in Cystobactamids to the Broad-Spectrum, Resistance-Breaking Antibiotic CN-CC-861

Kohnhäuser D, Seedorf T, Cirnski K, Heimann D, Coetzee J, Sordello S, Richter J, Stappert M, Sabuco J, Corbett D, …, Kirschning A, Brönstrup M (2024)

J. Med. Chem.DOI: 10.1021/acs.jmedchem.4c00927&ref=pdf

Isofunctional but Structurally Different Methyltransferases for Dithiolopyrrolone Diversification

Su L, Huber E, Westphalen M, Gellner J, Bode E, Köbel T, Grün P, Alanjary M, Glatter T, Cirnski K, …, Groll M, Bode H (2024)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202410799

The HIPS 2024 symposium: highlighting advances in pharmaceutical sciences in infection research

Mayoka G, Krug D, Loretz B, Bozhüyük K, Empting M, Hirsch A, Müller R (2024)

Trends in MicrobiologyDOI: 10.1016/j.tim.2024.07.007

Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE

Braun-Cornejo M, Ornago C, Sonawane V, Haupenthal J, Kany A, Diamanti E, Jézéquel G, Reiling N, Blankenfeldt W, Maas P, Hirsch A (2024)

ACS omegaDOI: 10.1021/acsomega.4c05537

Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes

Chan A, Ho T, Fathoni I, Hamid R, Hirsch A, Saliba K, Leeper F (2024)

RSC Med. Chem. 15 (5): 1773-1781DOI: 10.1039/D4MD00083H

Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes

Chen X, Zhao H, Wang C, Hamed M, Shang Q, Yang Y, Diao X, Sun X, Hu W, Jiang X, …, Wu D, Zhuang J (2024)

Int. J. Antimicrob. Agents 63 (5)DOI: 10.1016/j.ijantimicag.2024.107160

Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application

Hofer W, Deschner F, Jézéquel G, Pessanha de Carvalho L, Abdel-Wadood N, Pätzold L, Bernecker S, Morgenstern B, Kany A, Große M, …, Herrmann J, Müller R (2024)

Angewandte Chemie (International ed. in English) 63 (19)DOI: 10.1002/anie.202319765

Arg-biodynamers as antibiotic potentiators through interacting with Gram-negative outer membrane lipopolysaccharides

Kamal M, Bassil J, Loretz B, Hirsch A, Lee S, Lehr C (2024)

Eur J Pharm Biopharm 200DOI: 10.1016/j.ejpb.2024.114336

AI is a viable alternative to high throughput screening: a 318-target study

Wallach I, Hirsch, Anna K. H. et al. (2024)

Sci Rep 14 (1)DOI: 10.1038/s41598-024-54655-z

Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain

Gawriljuk V, Godoy A, Oerlemans R, Welker L, Hirsch A, Groves M (2024)

Nat. Commun. 15 (1)DOI: 10.1038/s41467-024-50671-9

Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity

Abdelsamie A, Hamed M, Schütz C, Röhrig T, Kany A, Schmelz S, Blankenfeldt W, Hirsch A, Hartmann R, Empting M (2024)

Eur. J. Med. Chem. 276DOI: 10.1016/j.ejmech.2024.116685

Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms

Osbelt L, Almási É, Wende M, Kienesberger S, Voltz A, Lesker T, Muthukumarasamy U, Knischewski N, Nordmann E, Bielecka A, …, Zechner E, Strowig T (2024)

Nat. Microbiol. 9 (7): 1792-1811DOI: 10.1038/s41564-024-01710-0

Investigation of the Odilorhabdin Biosynthetic Gene Cluster Using NRPS Engineering

Präve L, Seyfert C, Bozhüyük K, Racine E, Müller R, Bode H (2024)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202406389

The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages

Mashayekhi V, Schomisch A, Rasheed S, Aparicio-Puerta E, Risch T, Yildiz D, Koch M, Both S, Ludwig N, Legroux T, …, Hoppstädter J, Kiemer A (2024)

Cell communication and signaling : CCS 22 (1)DOI: 10.1186/s12964-024-01701-y

Mibianto: ultra-efficient online microbiome analysis through k-mer based metagenomics

Hirsch P, Molano L, Engel A, Zentgraf J, Rahmann S, Hannig M, Müller R, Kern F, Keller A, Schmartz G (2024)

Nucleic Acids ResDOI: 10.1093/nar/gkae364

Thermotropic liquid crystals in drug delivery: A versatile carrier for controlled release

Nesterkina M, Kravchenko* I, Hirsch A, Lehr C (2024)

Eur. J. Pharm. Biopharm. 200DOI: 10.1016/j.ejpb.2024.114343

Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy-coupling factor transporters (ECFTs)

Haupenthal J, Rafehi M, Kany A, Lespine A, Stefan K, Hirsch* A, Stefan* S (2024)

Arch. Pharm.DOI: 10.1002/ardp.202400267

Molecular networking and computational NMR analyses uncover six polyketide-terpene hybrids from termite-associated Xylaria isolates

Lee S, Dayras M, Fricke J, Guo H, Balluff S, Schalk F, Yu J, Jeong S, Morgenstern B, Slippers B, Beemelmanns C, Kim K (2024)

Commun Chem 7 (1)DOI: 10.1038/s42004-024-01210-6

Genetic regulation of L-tryptophan metabolism in Psilocybe mexicana supports psilocybin biosynthesis

Seibold P, Dörner S, Fricke J, Schäfer T, Beemelmanns C, Hoffmeister D (2024)

Fungal biology and biotechnology 11 (1)DOI: 10.1186/s40694-024-00173-6

Metabolism and cytotoxicity studies of the two hallucinogens 1cP-LSD and 4-AcO-DET in human liver and zebrafish larvae models using LC-HRMS/MS and a high-content screening assay

Gampfer T, Schütz V, Schippers P, Rasheed S, Baumann J, Wagmann L, Pulver B, Westphal F, Flockerzi V, Müller R, Meyer M (2024)

Journal of pharmaceutical and biomedical analysis 245DOI: 10.1016/j.jpba.2024.116187

Point mutations in the ygiV promoter region lead to cystobactamid resistance and reduced virulence in E. coli

Müller R, Risch T, Kolling D, Mostert D, Seedorf T, Heimann D, Kohnhäuser D, Deschner F, Fries F, Solga D, …, Herrmann J, Sieber S (2024)

BookDOI: 10.21203/rs.3.rs-3751821/v1

Time series of chicken stool metagenomics and egg metabolomics in changing production systems: preliminary insights from a proof-of-concept

Rosch M, Rehner J, Schmartz G, Manier S, Becker U, Müller R, Meyer M, Keller A, Becker S, Keller V (2024)

One health outlook 6 (1)DOI: 10.1186/s42522-024-00100-0

Targeting Intracellular Bacteria with Dual Drug-loaded Lactoferrin Nanoparticles

Andima M, Boese A, Paul P, Koch M, Loretz B, Lehr C (2024)

ACS Infect. Dis.DOI: 10.1021/acsinfecdis.4c00045

Structure Revision of a Widespread Marine Sulfonolipid Class Based on Isolation and Total Synthesis

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Is Simultaneous Binding to DNA and Gyrase Important for the Antibacterial Activity of Cystobactamids?

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Mining the microbiota for antibiotics

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