Publications
Publication Highlights
Have a look at our latest discoveries.
Publication database
2023
Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis
Adam S, Zheng D, Klein A, Volz C, Mullen W, Shirran S, Smith B, Kalinina O, Müller R, Koehnke J (2023)
Nature chemistry 15 (4): 560-568DOI: 10.1038/s41557-023-01153-w
Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues
Wagner V, Kern F, Hahn O, Schaum N, Ludwig N, Fehlmann T, Engel A, Henn D, Rishik S, Isakova A, …, Wyss-Coray T, Keller A (2023)
Nat BiotechnolDOI: 10.1038/s41587-023-01751-6
The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition
Koller T, Scheid U, Kösel T, Herrmann J, Krug D, Boshoff H, Beckert B, Evans J, Schlemmer J, Sloan B, …, Wilson D, Müller R (2023)
J. Am. Chem. Soc. 145 (2): 851-863DOI: 10.1021/jacs.2c08816
Insights into the biosynthesis of icumazole, unveiling a distinctive family of crotonyl-CoA carboxylase/reductase
Xie F, Kiefer A, Hirsch A, Kalinina O, Fu C, Müller R (2023)
Cell Reports Physical Science 4 (5)DOI: 10.1016/j.xcrp.2023.101394
Engineered Biosynthesis of Complex Disorazol Polyketides in a Streamlined Burkholderia thailandensis
Wang Z, Liu X, Zhou H, Liu Y, Tu Q, Huo L, Yan F, Müller R, Zhang Y, Xu X (2023)
ACS synthetic biology 12 (4): 971-977DOI: 10.1021/acssynbio.2c00610
Genome-Guided Discovery of the Myxobacterial Thiolactone-Containing Sorangibactins
Gao Y, Walt C, Bader C, Müller R (2023)
ACS chemical biology 18 (4): 924-932DOI: 10.1021/acschembio.3c00063
Evaluation of extraction methods for untargeted metabolomic studies for future applications in zebrafish larvae infection models
Schippers P, Rasheed S, Park Y, Risch T, Wagmann L, Hemmer S, Manier S, Müller R, Herrmann J, Meyer M (2023)
Sci. Rep. 13 (1)DOI: 10.1038/s41598-023-34593-y
Facile Production of the Pseudomonas aeruginosa Virulence Factor LasB in E. coli for Structure-Based Drug Design
Kolling D, Haupenthal J, Hirsch A, Köhnke J (2023)
ChemBioChemDOI: 10.1002/cbic.202300185
Structure Elucidation and Biosynthesis of Nannosterols A and B, Myxobacterial Sterols from Nannocystis sp. MNa10993
Akone S, Hug J, Kaur A, Garcia R, Müller R (2023)
Journal of natural products 86 (4): 915-923DOI: 10.1021/acs.jnatprod.2c01143
Sorangicin A Is Active against Chlamydia in Cell Culture, Explanted Fallopian Tubes, and Topical In Vivo Treatment
Graspeuntner S, Koethke K, Scholz C, Semmler L, Lupatsii M, Kirchhoff L, Herrmann J, Rox K, Wittstein K, Käding N, …, Shima K, Rupp J (2023)
Antibiotics 12 (5)DOI: 10.3390/antibiotics12050795
miEAA 2023: updates, new functional microRNA sets and improved enrichment visualizations
Aparicio-Puerta E, Hirsch P, Schmartz G, Kern F, Fehlmann T, Keller A (2023)
Nucleic Acids ResDOI: 10.1093/nar/gkad392
Isolation, (bio)synthetic studies and evaluation of antimicrobial properties of drimenol-type sesquiterpenes of Termitomyces fungi
Kreuzenbeck N, Dhiman S, Roman D, Burkhardt I, Conlon B, Fricke J, Guo H, Blume J, Görls H, Poulsen M, …, Arndt H, Beemelmanns C (2023)
Commun Chem 6 (1)DOI: 10.1038/s42004-023-00871-z
Synthesis of Aryl‐ and Alkyl‐Containing 3‐Methylene‐5‐hydroxy Esters via a Barbier Allylation Reaction
Bartholomäus A, Roman D, Al-Jammal W, Vilotijevic I, Beemelmanns C (2023)
Eur. J. Org. Chem.DOI: 10.1002/ejoc.202300177
The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection
Bublitz A, Brauer M, Wagner S, Hofer W, Müsken M, Deschner F, Lesker T, Neumann-Schaal M, Paul L, Nübel U, …, Fuchs T, Strowig T (2023)
Cell Host MicrobeDOI: 10.1016/j.chom.2023.04.003
Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate
Gawriljuk V, Oerlemans R, Gierse R, Jotwani R, Hirsch A, Groves M (2023)
Crystals 13 (5)DOI: 10.3390/cryst13050737
Adaptations of Pseudoxylaria towards a comb-associated lifestyle in fungus-farming termite colonies
Fricke J, Schalk F, Kreuzenbeck N, Seibel E, Hoffmann J, Dittmann G, Conlon B, Guo H, Wilhelm de Beer Z, Vassão D, …, Poulsen M, Beemelmanns C (2023)
ISME J.: 1-15DOI: 10.1038/s41396-023-01374-4
Multiple mutations in the Nav1.4 sodium channel of New Guinean toxic birds provide autoresistance to deadly batrachotoxin
Bodawatta K, Hu H, Schalk F, Daniel J, Maiah G, Koane B, Iova B, Beemelmanns C, Poulsen M, Jønsson K (2023)
Mol. Ecol.DOI: 10.1111/mec.16878
Identification of Compounds Preventing A. fumigatus Biofilm Formation by Inhibition of the Galactosaminogalactan Deacetylase Agd3
Seegers C, Lee D, Zarnovican P, Kirsch S, Müller R, Haselhorst T, Routier F (2023)
International journal of molecular sciences 24 (3)DOI: 10.3390/ijms24031851
Not Every Hit-Identification Technique Works on 1-Deoxy-d-Xylulose 5-Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign
Johannsen S, Gierse R, Olshanova A, Smerznak E, Laggner C, Eschweiler L, Adeli Z, Hamid R, Alhayek A, Reiling N, Haupenthal J, Hirsch A (2023)
ChemMedChemDOI: 10.1002/cmdc.202200590
Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster
Nesterkina M, Bilokon S, Alieksieieva T, Kravchenko I, Hirsch A (2023)
Toxicol. Rep. 10DOI: 10.1016/j.toxrep.2023.02.009
Fighting antibiotic resistance-strategies and (pre)clinical developments to find new antibacterials
Walesch S, Birkelbach J, Jézéquel G, Haeckl F, Hegemann J, Hesterkamp T, Hirsch A, Hammann P, Müller R (2023)
EMBO reports 24 (1)DOI: 10.15252/embr.202256033
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle
Hamed M, Abdelsamie A, Rox K, Schütz C, Kany A, Röhrig T, Schmelz S, Blankenfeldt W, Arce-Rodriguez A, Borrero-de Acuña J, …, Hartmann R, Empting M (2023)
Adv. Sci. (Online)DOI: 10.1002/advs.202204443
Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization
Girardini M, Ferlenghi F, Annunziato G, Degiacomi G, Papotti B, Marchi C, Sammartino J, Rasheed S, Contini A, Pasca M, …, Costantino G, Pieroni M (2023)
European journal of medicinal chemistry 245DOI: 10.1016/j.ejmech.2022.114916
2022
Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17
Iram T, Kern F, Kaur A, Myneni S, Morningstar A, Shin H, Garcia M, Yerra L, Palovics R, Yang A, …, Zuchero J, Wyss-Coray T (2022)
Nature 605 (7910): 509-515DOI: 10.1038/s41586-022-04722-0
Persicamidines-Unprecedented Sesquarterpenoids with Potent Antiviral Bioactivity against Coronaviruses
Keller L, Oueis E, Kaur A, Safaei N, Kirsch S, Gunesch A, Haid S, Rand U, Cicin-Šain L, Fu C, …, Pietschmann T, Müller R (2022)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202214595
Darobactins Exhibiting Superior Antibiotic Activity by Cryo-EM Structure Guided Biosynthetic Engineering
Seyfert C, Porten C, Yuan B, Deckarm S, Panter F, Bader C, Coetzee J, Deschner F, Tehrani K, Higgins P, …, Herrmann J, Müller R (2022)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202214094
Current Developments in Antibiotic Discovery – Global Microbial Diversity as Source for Evolutionary Optimized Anti-infectives
Hegemann J, Birkelbach J, Walesch S, Müller R (2022)
EMBO Rep. published concurrently
Large-Scale Interlaboratory DI-FT-ICR MS Comparability Study Employing Various Systems
Forcisi S, Moritz F, Thompson C, Kanawati B, Uhl J, Afonso C, Bader C, Barsch A, Boughton B, Chu R, …, Laukien F, Schmitt-Kopplin P (2022)
Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.2c00082
Total synthesis of Myxoprincomide, a secondary metabolite from Myxococcus xanthus
Kohr M, Walt C, Dastbaz J, Müller R, Kazmaier U (2022)
Org. Biomol. Chem.DOI: 10.1039/d2ob02021a
Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening
Di Zhu, Johannsen S, Masini T, Simonin C, Haupenthal J, Illarionov B, Andreas A, Awale M, Gierse R, van der Laan T, …, Reymond J, Hirsch A (2022)
Chem. Sci. 13 (36): 10686-10698DOI: 10.1039/D2SC02371G
Thiamyxins: Structure and Biosynthesis of Myxobacterial RNA-Virus Inhibitors
Haack P, Harmrolfs K, Bader C, Garcia R, Gunesch A, Haid S, Popoff A, Voltz A, Kim H, Bartenschlager R, Pietschmann T, Müller R (2022)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202212946
Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin
Couturier C, Groß S, Tesmar A, Hoffmann J, Deckarm S, Fievet A, Dubarry N, Taillier T, Pöverlein C, Stump H, …, Müller R, Renard S (2022)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202210747
The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB
Camberlein V, Jézéquel G, Haupenthal J, Hirsch A (2022)
Antibiotics 11 (8)DOI: 10.3390/antibiotics11081060
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism
Chen F, Elgaher W, Winterhoff M, Büssow K, Waqas F, Graner E, Pires-Afonso Y, Casares Perez L, La Vega L, Sahini N, …, Hirsch A, Pessler F (2022)
Nature metabolism 4 (5): 534-546DOI: 10.1038/s42255-022-00577-x
Regio- and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives
Müller R, Hofer W, Oueis E, Abou Fayad A, Deschner F, Andreas A, Carvalho L, Hüttel S, Bernecker S, Pätzold L, …, Held J, Herrmann J (2022)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202202816
Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis
Camberlein V, Fléau C, Sierocki P, Li L, Gealageas R, Bosc D, Guillaume V, Warenghem S, Leroux F, Rosell M, …, Bouvier M, Deprez-Poulain R (2022)
Angew. Chemie 134 (39)DOI: 10.1002/ange.202203560
Crystal structure of natural product argyrin-D determined by 3D electron diffraction
Gorelik T, Tehrani K, Gruene T, Monecke T, Niessing D, Kaiser U, Blankenfeldt W, Müller R (2022)
CrystEngComm 24 (33): 5885-5889DOI: 10.1039/D2CE00707J
Bursts in biosynthetic gene cluster transcription are accompanied by surges of natural compound production in the myxobacterium Sorangium sp
Boldt J, Lukoševiciute L, Fu C, Steglich M, Bunk B, Junker V, Gollasch A, Trunkwalter B, Mohr K, Beckstette M, …, Müller R, Nübel U (2022)
BookDOI: 10.1101/2022.11.24.517636
Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors
Wimmer S, Hoff K, Martin B, Grewer M, Denni L, Lascorz Massanet R, Raimondi M, Bülbül E, Melesina J, Hotop S, …, Sippl W, Holl R (2022)
Bioorganic chemistry 131DOI: 10.1016/j.bioorg.2022.106331
Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape
Lee S, Nasr S, Rasheed S, Liu Y, Hartwig O, Kaya C, Boese A, Koch M, Herrmann J, Müller R, …, Hirsch A, Lehr C (2022)
Journal of controlled release : official journal of the Controlled Release Society 353: 915-929DOI: 10.1016/j.jconrel.2022.12.018
Current Developments in Antibiotic Discovery – Global Microbial Diversity as Source for Evolutionary Optimized Anti-infectives
Hegemann J, Birkelbach J, Walesch S, Müller R (2022)
EMBO Rep. published concurrently
Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation
Ibrahim A, Abdel Gaber S, Fawzi Kabil M, Ahmed-Farid O, Hirsch A, El-Sherbiny I, Nasr M (2022)
Expert Opin. Drug Deliv. 19 (11): 1549-1560DOI: 10.1080/17425247.2022.2139370
Introduction to themed collection on fragment-based drug discovery
Rees D, Hirsch A, Erlanson D (2022)
RSC Med. Chem. 13DOI: 10.1039/D2MD90037H
The chemical ecology of the fungus-farming termite symbiosis
Schmidt S, Kildgaard S, Guo H, Beemelmanns C, Poulsen M (2022)
Nat. Prod. Rep. 39 (2): 231-248DOI: 10.1039/d1np00022e
A Modular Approach to the Antifungal Sphingofungin Family: Concise Total Synthesis of Sphingofungin A and C
Raguž L, Peng C, Kaiser M, Görls H, Beemelmanns C (2022)
Angewandte Chemie (International ed. in English) 61 (5)DOI: 10.1002/anie.202112616
Structural and Functional Analysis of Bacterial Sulfonosphingolipids and Rosette-Inducing Factor 2 (RIF-2) by Mass Spectrometry-Guided Isolation and Total Synthesis
Leichnitz D, Peng C, Raguž L, Rutaganira F, Jautzus T, Regestein L, King N, Beemelmanns C (2022)
Chem. Eur. J. 28 (8)DOI: 10.1002/chem.202103883
Signalling molecules inducing metamorphosis in marine organisms
Rischer M, Guo H, Beemelmanns C (2022)
Nat. Prod. Rep. 39 (9): 1833-1855DOI: 10.1039/d1np00073j
Application of pyrrolo-protected amino aldehydes in the stereoselective synthesis of anti-1,2-amino alcohols
Sauer M, Beemelmanns C (2022)
Chemical communications (Cambridge, England) 58 (64): 8990-8993DOI: 10.1039/d2cc02317b
Identification of the new prenyltransferase Ubi-297 from marine bacteria and elucidation of its substrate specificity
Amiri Moghaddam J, Guo H, Willing K, Wichard T, Beemelmanns C (2022)
Beilstein journal of organic chemistry 18: 722-731DOI: 10.3762/bjoc.18.72
GNPS-Guided Discovery of Madurastatin Siderophores from the Termite-Associated Actinomadura sp. RB99
Lee S, Schalk F, Schwitalla J, Guo H, Yu J, Song M, Jung W, Beer Z, Beemelmanns C, Kim K (2022)
Chem. Eur. J. 28 (36)DOI: 10.1002/chem.202200612
Comparative Genomic and Metabolomic Analysis of Termitomyces Species Provides Insights into the Terpenome of the Fungal Cultivar and the Characteristic Odor of the Fungus Garden of Macrotermes natalensis Termites
Kreuzenbeck N, Seibel E, Schwitalla J, Fricke J, Conlon B, Schmidt S, Hammerbacher A, Köllner T, Poulsen M, Hoffmeister D, Beemelmanns C (2022)
mSystems 7 (1)DOI: 10.1128/msystems.01214-21
Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition
Hoefgen S, Bissell A, Huang Y, Gherlone F, Raguž L, Beemelmanns C, Valiante V (2022)
Microbiology Spectrum 10 (5)DOI: 10.1128/spectrum.01331-22
Insights into the Metabolomic Capacity of Podaxis and Isolation of Podaxisterols A-D, Ergosterol Derivatives Carrying Nitrosyl Cyanide-Derived Modifications
Guo H, Daniel J, Seibel E, Burkhardt I, Conlon B, Görls H, Vassão D, Dickschat J, Poulsen M, Beemelmanns C (2022)
Journal of natural products 85 (9): 2159-2167DOI: 10.1021/acs.jnatprod.2c00380
Synthesis of Functionalized δ-Hydroxy-β-keto Esters and Evaluation of Their Anti-inflammatory Properties
Grosse M, Günther K, Jordan P, Roman D, Werz O, Beemelmanns C (2022)
Chembiochem : a European journal of chemical biology 23 (9)DOI: 10.1002/cbic.202200073
Biosynthesis of the Sphingolipid Inhibitors Sphingofungins in Filamentous Fungi Requires Aminomalonate as a Metabolic Precursor
Bissell A, Rautschek J, Hoefgen S, Raguž L, Mattern D, Saeed N, Janevska S, Jojic K, Huang Y, Kufs J, …, Beemelmanns C, Valiante V (2022)
ACS chemical biology 17 (2): 386-394DOI: 10.1021/acschembio.1c00839
The inherent antibiotic activity of myxobacteria-derived autofluorescent outer membrane vesicles is switched on and off by light stimulation
Lapuhs P, Heinrich E, Garcia R, Goes A, Frank N, Bollenbach L, Stibane V, Kuhn T, Koch M, Kiemer A, …, Fuhrmann K, Fuhrmann G (2022)
NanoscaleDOI: 10.1039/d2nr02743g
Targeting undruggable carbohydrate recognition sites through focused fragment library design
Shanina E, Kuhaudomlarp S, Siebs E, Fuchsberger F, Denis M, da Silva Figueiredo Celestino Gomes P, Clausen M, Seeberger P, Rognan D, Titz A, Imberty A, Rademacher C (2022)
Commun Chem 5 (1): 1-11DOI: 10.1038/s42004-022-00679-3
NamZ1 and NamZ2 from the Oral Pathogen Tannerella forsythia Are Peptidoglycan Processing Exo-β-N-Acetylmuramidases with Distinct Substrate Specificities
Borisova M, Balbuchta K, Lovering A, Titz A, Mayer C (2022)
J. Bacteriol. 204 (3)DOI: 10.1128/jb.00597-21
Targeting the Central Pocket of the Pseudomonas aeruginosa Lectin LecA
Siebs E, Shanina E, Kuhaudomlarp S, da Silva Figueiredo Celestino Gomes P, Fortin C, Seeberger P, Rognan D, Rademacher C, Imberty A, Titz A (2022)
Chembiochem : a European journal of chemical biology 23 (3)DOI: 10.1002/cbic.202100563
β-Boronic Acid-Substituted Bodipy Dyes for Fluorescence Anisotropy Analysis of Carbohydrate Binding
Hoffmann C, Jourdain M, Grandjean A, Titz A, Jung G (2022)
Analytical chemistry 94 (16): 6112-6119DOI: 10.1021/acs.analchem.1c04654
Pineapple Lectin AcmJRL binds SARS-CoV-2 Spike Protein in a carbohydrate-dependent fashion
Meiers J, Dastbaz J, Adam S, Rasheed S, Kirsch S, Meiser P, Gross P, Müller R, Titz A (2022)
Chembiochem : a European journal of chemical biologyDOI: 10.1002/cbic.202200463
The Glycan-Specificity of the Pineapple Lectin AcmJRL and its Carbohydrate-Dependent Binding of the SARS-CoV-2 Spike Protein
Meiers J, Dastbaz J, Adam S, Rasheed S, Kirsch S, Meiser P, Gross P, Müller R, Titz A (2022)
BookDOI: 10.1101/2022.05.27.493400
Lectin-Targeted Prodrugs Activated by Pseudomonas aeruginosa for Self-Destructive Antibiotic Release
Meiers J, Rox K, Titz A (2022)
Journal of medicinal chemistry 65 (20): 13988-14014DOI: 10.1021/acs.jmedchem.2c01214
Neutralizing the Impact of the Virulence Factor LecA from Pseudomonas aeruginosa on Human Cells with New Glycomimetic Inhibitors
Zahorska E, Rosato F, Stober K, Kuhaudomlarp S, Meiers J, Hauck D, Reith D, Gillon E, Rox K, Imberty A, Römer W, Titz A (2022)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202215535
Discovery of N-β-l-Fucosyl Amides as High-Affinity Ligands for the Pseudomonas aeruginosa Lectin LecB
Mala P, Siebs E, Meiers J, Rox K, Varrot A, Imberty A, Titz A (2022)
Journal of medicinal chemistry 65 (20): 14180-14200DOI: 10.1021/acs.jmedchem.2c01373
An Efficient Way to Screen Inhibitors of Energy-Coupling Factor (ECF) Transporters in a Bacterial Uptake Assay
Bousis S, Winkler S, Haupenthal J, Fulco F, Diamanti E, Hirsch A (2022)
International journal of molecular sciences 23 (5)DOI: 10.3390/ijms23052637
Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages
Sake S, Kosch C, Blockus S, Haid S, Gunesch A, Zhang X, Friesland M, Trummer S, Grethe C, Kühnel A, …, Schulz T, Pietschmann T (2022)
Antimicrobial agents and chemotherapyDOI: 10.1128/aac.01032-22
Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases
Alhayek A, Abdelsamie A, Schönauer E, Camberlein V, Hutterer E, Posselt G, Serwanja J, Blöchl C, Huber C, Haupenthal J, …, Wessler S, Hirsch A (2022)
Journal of medicinal chemistry 65 (19): 12933-12955DOI: 10.1021/acs.jmedchem.2c00785
Expanding the Ajudazol Cytotoxin Scaffold: Insights from Genome Mining, Biosynthetic Investigations, and Novel Derivatives
Zeng H, Birkelbach J, Hoffmann J, Popoff A, Volz C, Müller R (2022)
Journal of natural productsDOI: 10.1021/acs.jnatprod.2c00637
Interference with lipoprotein maturation sensitizes methicillin-resistant Staphylococcus aureus to human group IIA secreted phospholipase A 2 and daptomycin
Kuijk M, Wu Y, van Hensbergen V, Shanlitourk G, Payré C, Lambeau G, Herrmann J, Müller R, van Strijp J, Pannekoek Y, Touqui L, van Sorge N (2022)
BookDOI: 10.1101/2022.02.06.476181
Natural products lysobactin and sorangicin A show in vitro activity against Mycobacterium abscessus complex
Sullivan J, Yao J, Courtine C, Lupien A, Herrmann J, Müller R, Behr M (2022)
BookDOI: 10.1101/2022.06.27.497873
Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA
Fathalla R, Fröhner W, Bader C, Fischer P, Dahlem C, Chatterjee D, Mathea S, Kiemer A, Arthanari H, Müller R, …, Ducho C, Engel M (2022)
Journal of medicinal chemistryDOI: 10.1021/acs.jmedchem.2c01275
Pharmacology and early ADMET data of corallopyronin A, a natural product with macrofilaricidal anti-wolbachial activity in filarial nematodes
Ehrens A, Schiefer A, Krome A, Becker T, Rox K, Neufeld H, Aden T, Wagner K, Müller R, Grosse M, …, Pfarr K, Hoerauf A (2022)
Front. Trop. Dis 3DOI: 10.3389/fitd.2022.983107
A novel tumor-targeting strain of Xenorhabdus stockiae exhibits potent biological activities
Zhang C, Chen H, Hüttel S, Hu S, Zhang W, Ding X, Yin J, Yin Y, Müller R, Xia L, Zhang Y, Tu Q (2022)
Frontiers in Bioengineering and Biotechnology 10DOI: 10.3389/fbioe.2022.984197
Discovery, Biosynthesis and Biological Activity of a Succinylated Myxochelin from the Myxobacterial strain MSr12020
Okoth D, Hug J, Garcia R, Müller R (2022)
BookDOI: 10.20944/preprints202209.0147.v1
Leaky gut model of the human intestinal mucosa for testing siRNA-based nanomedicine targeting JAK1
Hartwig O, Loretz B, Nougarede A, Jary D, Sulpice E, Gidrol X, Navarro F, Lehr C (2022)
J Control Release 345: 646-660DOI: 10.1016/j.jconrel.2022.03.037
NPvis: An Interactive Visualizer of Peptidic Natural Product-MS/MS Matches
Kunyavskaya O, Mikheenko A, Gurevich A (2022)
Metabolites 12 (8)DOI: 10.3390/metabo12080706
Total Synthesis and Functional Evaluation of IORs, Sulfonolipid-based Inhibitors of Cell Differentiation in Salpingoeca rosetta
Raguž L, Peng C, Rutaganira F, Krüger T, Stanišic A, Jautzus T, Kries H, Kniemeyer O, Brakhage A, King N, Beemelmanns C (2022)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202209105
Discovery of a Unique Structural Motif in Lanthipeptide Synthetases for Substrate Binding and Interdomain Interactions
Huang S, Wang Y, Cai C, Xiao X, Liu S, Ma Y, Xie X, Liang Y, Chen H, Zhu J, …, Wei W, Wang H (2022)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202211382
BusyBee Web: towards comprehensive and differential composition-based metagenomic binning
Schmartz G, Hirsch P, Amand J, Dastbaz J, Fehlmann T, Kern F, Müller R, Keller A (2022)
Nucleic Acids ResDOI: 10.1093/nar/gkac298
Screening of Natural Products and Small Molecules Uncovers Novel Coronavirus 1a/1b Frameshifting Inhibitors with Antiviral Properties
Kibe A, Elgaher W, Rand U, Zimmer M, Kany A, Hermann J, Müller R, Cicin-Sain L, Hirsch A, Caliskan N (2022)
SSRN JournalDOI: 10.2139/ssrn.4157446
Design, Synthesis, Antimicrobial Activity, and Molecular Docking of Some New Diclofenac Derivatives
Tolba M, Hamed M, Sayed M, Kamal El-Dean A, Abdel-Mohsen S, Ibrahim O, Elgaher W, Hirsch A, Saddik A (2022)
Polycyclic Aromatic Compounds: 1-16DOI: 10.1080/10406638.2022.2102661
Structural analysis of 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding
Hamid R, Adam S, Lacour A, Gomez L, Hirsch A (2022)
bioRxivDOI: 10.1101/2022.07.04.498669
Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry
Bagnolini G, Balboni B, Schipani F, Gioia D, Veronesi M, Franco F, Kaya C, Jumde R, Ortega J, Girotto S, …, Roberti M, Cavalli A (2022)
ACS Med. Chem. Lett. 13 (8): 1262-1269DOI: 10.1021/acsmedchemlett.2c00063
Systematic cross-biospecimen evaluation of DNA extraction kits for long- and short-read multi-metagenomic sequencing studies
Rehner J, Schmartz G, Groeger L, Dastbaz J, Ludwig N, Hannig M, Rupf S, Seitz B, Flockerzi E, Berger T, …, Keller A, Müller R (2022)
Genomics Proteomics BioinformaticsDOI: 10.1016/j.gpb.2022.05.006
Three New Stigmatellin Derivatives Reveal Biosynthetic Insights of Its Side Chain Decoration
Okoth D, Hug J, Garcia R, Müller R (2022)
Molecules (Basel, Switzerland) 27 (14)DOI: 10.3390/molecules27144656
Corallopyronin A: antimicrobial discovery to preclinical development
Krome A, Becker T, Kehraus S, Schiefer A, Gütschow M, Chaverra-Muñoz L, Hüttel S, Jansen R, Stadler M, Ehrens A, …, Wagner K, König G (2022)
Nat. Prod. Rep.DOI: 10.1039/d2np00012a
Corallococcus soli sp. Nov., a Soil Myxobacterium Isolated from Subtropical Climate, Chalus County, Iran, and Its Potential to Produce Secondary Metabolites
Babadi Z, Garcia R, Ebrahimipour G, Risdian C, Kämpfer P, Jarek M, Müller R, Wink J (2022)
Microorganisms 10 (7)DOI: 10.3390/microorganisms10071262
Themed issue: Extracellular vesicles in drug delivery and bioengineering
Fuhrmann G, Lehr C, Schiffelers R (2022)
Advanced Drug Delivery Reviews 181DOI: 10.1016/j.addr.2021.114073
Nano-in-Microparticles for Aerosol Delivery of Antibiotic-Loaded, Fucose-Derivatized, and Macrophage-Targeted Liposomes to Combat Mycobacterial Infections: In Vitro Deposition, Pulmonary Barrier Interactions, and Targeted Delivery
Huck B, Thiyagarajan D, Bali A, Boese A, Besecke K, Hozsa C, Gieseler R, Furch M, Carvalho-Wodarz C, Waldow F, …, Loretz B, Lehr C (2022)
Advanced healthcare materials 11 (11)DOI: 10.1002/adhm.202102117
Spray-dried pneumococcal membrane vesicles are promising candidates for pulmonary immunization
Mehanny M, Boese A, Bornamehr B, Hoppstädter J, Presser V, Kiemer A, Lehr C, Fuhrmann G (2022)
International journal of pharmaceutics 621DOI: 10.1016/j.ijpharm.2022.121794
An Outer Membrane Vesicle-Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability
Richter R, Kamal M, Koch M, Niebuur B, Huber A, Goes A, Volz C, Vergalli J, Kraus T, Müller R, …, Pagès J, Lehr C (2022)
Advanced healthcare materials 11 (5)DOI: 10.1002/adhm.202101180
Targeting extracellular lectins of Pseudomonas aeruginosa with glycomimetic liposomes
Metelkina O, Huck B, O'Connor J, Koch M, Manz A, Lehr C, Titz A (2022)
Journal of Materials Chemistry B 10 (4): 537-548DOI: 10.1039/d1tb02086b
Transferring Microclusters of P. aeruginosa Biofilms to the Air-Liquid Interface of Bronchial Epithelial Cells for Repeated Deposition of Aerosolized Tobramycin
Horstmann J, Laric A, Boese A, Yildiz D, Röhrig T, Empting M, Frank N, Krug D, Müller R, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2022)
ACS infectious diseases 8 (1): 137-149DOI: 10.1021/acsinfecdis.1c00444
Exploring the permeation of fluoroquinolone metalloantibiotics across outer membrane porins by combining molecular dynamics simulations and a porin-mimetic in vitro model
Sousa C, Coimbra J, Richter R, Morais-Cabral J, Ramos M, Lehr C, Fernandes P, Gameiro P (2022)
Biochimica et biophysica acta. Biomembranes 1864 (3)DOI: 10.1016/j.bbamem.2021.183838
Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: Composition, structure and barrier properties
Huck B, Murgia X, Frisch S, Hittinger M, Hidalgo A, Loretz B, Lehr C (2022)
Advanced Drug Delivery Reviews 183DOI: 10.1016/j.addr.2022.114141
Yields and Immunomodulatory Effects of Pneumococcal Membrane Vesicles Differ with the Bacterial Growth Phase
Mehanny M, Kroniger T, Koch M, Hoppstädter J, Becher D, Kiemer A, Lehr C, Fuhrmann G (2022)
Advanced healthcare materials 11 (5)DOI: 10.1002/adhm.202101151
Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters
Kiefer A, Bousis S, Hamed M, Diamanti E, Haupenthal J, Hirsch A (2022)
J. Med. Chem.DOI: 10.1021/acs.jmedchem.1c02114
Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents
Kaya C, Hirsch A (2022)
Chimia 76 (5)DOI: 10.2533/chimia.2022.402
Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors
Hamdy J, Emadeldin N, Hamed M, Frakolaki E, Katsamakas S, Vassilaki N, Zoidis G, Hirsch A, Abdel-Halim M, Abadi A (2022)
Pharmaceuticals 15 (5)DOI: 10.3390/ph15050632
First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization
Gierse R, Oerlemans R, Reddem E, Gawriljuk V, Alhayek A, Baitinger D, Jakobi H, Laber B, Lange G, Hirsch A, Groves M (2022)
Sci. Rep. 12 (1)DOI: 10.1038/s41598-022-11205-9
Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi
Kirsch S, Haeckl F, Müller R (2022)
Nat. Prod. Rep.DOI: 10.1039/d1np00067e
N-Aryl-2-iso-butylmercaptoacetamides: the discovery of highly potent and selective inhibitors of Pseudomonas aeruginosa virulence factor LasB and Clostridium histolyticum virulence factor ColH
Voos K, Yahiaoui S, Konstantinovic J, Schönauer E, Alhayek A, Sikandar A, Si Chaib K, Ramspoth T, Rox K, Haupenthal J, …, Ducho C, Hirsch A (2022)
ChemRxivDOI: 10.26434/chemrxiv-2022-fjrqr
Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa
Kaya C, Walter I, Alhayek A, Shafiei R, Jézéquel G, Andreas A, Konstantinovic J, Schönauer E, Sikandar A, Haupenthal J, …, Hartmann R, Hirsch A (2022)
ACS Infect. Dis.DOI: 10.1021/acsinfecdis.1c00628
Induction of Liver Size Reduction in Zebrafish Larvae by the Emerging Synthetic Cannabinoid 4F-MDMB-BINACA and Its Impact on Drug Metabolism
Park Y, Dahlem C, Meyer M, Kiemer A, Müller R, Herrmann J (2022)
Molecules (Basel, Switzerland) 27 (4)DOI: 10.3390/molecules27041290
N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases
Kaya C, Konstantinovic J, Kany A, Andreas A, Kramer J, Brunst S, Weizel L, Rotter M, Frank D, Yahiaoui S, …, Wichelhaus T, Hirsch A (2022)
Journal of medicinal chemistry 65 (5): 3913-3922DOI: 10.1021/acs.jmedchem.1c01755
Myxobacteria of the Cystobacterineae Suborder Are Producers of New Vitamin K2 Derived Myxoquinones
Panter F, Popoff A, Garcia R, Krug D, Müller R (2022)
Microorganisms 10 (3)DOI: 10.3390/microorganisms10030534
PLSDB: advancing a comprehensive database of bacterial plasmids
Schmartz G, Hartung A, Hirsch P, Kern F, Fehlmann T, Müller R, Keller A (2022)
Nucleic Acids Res 50 (D1): 273-DOI: 10.1093/nar/gkab1111
Metabolic profiling of S-praziquantel: Structure elucidation using the crystalline sponge method in combination with mass spectrometry and nuclear magnetic resonance
Rosenberger L, Jenniches J, Essen C, Khutia A, Kühn C, Marx A, Georgi K, Hirsch A, Hartmann R, Badolo L (2022)
Drug metabolism and disposition: the biological fate of chemicalsDOI: 10.1124/dmd.121.000663
Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part
Megahed S, Rasheed S, Herrmann J, El-Hossary E, El-Shabrawy Y, Abadi A, Engel M, Müller R, Abdel-Halim M, Hamed M (2022)
Bioorg Med Chem Lett 59DOI: 10.1016/j.bmcl.2022.128531
New Deoxyenhygrolides from Plesiocystis pacifica Provide Insights into Butenolide Core Biosynthesis
Hug J, Kjaerulff L, Garcia R, Müller R (2022)
Marine drugs 20 (1)DOI: 10.3390/md20010072
Sandacrabins - Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium
Bader C, Panter F, Garcia R, Tchesnokov E, Haid S, Walt C, Spröer C, Kiefer A, Götte M, Overmann J, Pietschmann T, Müller R (2022)
Chem. Eur. J. 28 (10)DOI: 10.1002/chem.202104484
Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin‐Wound Infections
Alhayek A, Khan E, Schönauer E, Däinghaus T, Shafiei R, Voos K, Han M, Ducho C, Posselt G, Wessler S, …, del Campo A, Hirsch A (2022)
Adv. Therap.DOI: 10.1002/adtp.202100222
Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor
Drost M, Diamanti E, Fuhrmann K, Goes A, Shams A, Haupenthal J, Koch M, Hirsch A, Fuhrmann G (2022)
Pharmaceutics 14 (1)DOI: 10.3390/pharmaceutics14010004
Biotechnological production optimization of argyrins - a potent immunomodulatory natural product class
Pogorevc D, Müller R (2022)
Microbial Biotechnology 15 (1): 353-369DOI: 10.1111/1751-7915.13959
Inhibitors of Pseudomonas aeruginosa virulence factor LasB
Ducho C, Hartmann R, Haupenthal J, Hirsch A, Kany A, Kaya C, Konstantinovic J, Voos K, Walter I, Yahiaoui S, …, Jumde R, Kiefer A (2022)
Patent A61K31/095; A61K31/10; A61K31/167; A61K31/4184; A61K31/426; A61K31/428; A61K31/4406; A61P31/04; C07C323/60; C07D213/74; C07D235/30; C07D277/46; C07D277/82; C07D333/36; C07F9/38; C07F9/40; (WO2022043322A1)