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Researchers in HIPS Laboratory

Publications

Publication Highlights

Have a look at our latest discoveries.


Publication database

2023

The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition

Koller T, Scheid U, Kösel T, Herrmann J, Krug D, Boshoff H, Beckert B, Evans J, Schlemmer J, Sloan B, …, Wilson D, Müller R (2023)

J. Am. Chem. Soc. 145 (2): 851-863DOI: 10.1021/jacs.2c08816

Fighting antibiotic resistance-strategies and (pre)clinical developments to find new antibacterials

Walesch S, Birkelbach J, Jézéquel G, Haeckl F, Hegemann J, Hesterkamp T, Hirsch A, Hammann P, Müller R (2023)

EMBO reports 24 (1)DOI: 10.15252/embr.202256033

Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle

Hamed M, Abdelsamie A, Rox K, Schütz C, Kany A, Röhrig T, Schmelz S, Blankenfeldt W, Arce-Rodriguez A, Borrero-de Acuña J, …, Hartmann R, Empting M (2023)

Adv. Sci.DOI: 10.1002/advs.202204443

Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization

Girardini M, Ferlenghi F, Annunziato G, Degiacomi G, Papotti B, Marchi C, Sammartino J, Rasheed S, Contini A, Pasca M, …, Costantino G, Pieroni M (2023)

European journal of medicinal chemistry 245DOI: 10.1016/j.ejmech.2022.114916

2022

Persicamidines-Unprecedented Sesquarterpenoids with Potent Antiviral Bioactivity against Coronaviruses

Keller L, Oueis E, Kaur A, Safaei N, Kirsch S, Gunesch A, Haid S, Rand U, Cicin-Šain L, Fu C, …, Pietschmann T, Müller R (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202214595

Darobactins Exhibiting Superior Antibiotic Activity by Cryo-EM Structure Guided Biosynthetic Engineering

Seyfert C, Porten C, Yuan B, Deckarm S, Panter F, Bader C, Coetzee J, Deschner F, Tehrani K, Higgins P, …, Herrmann J, Müller R (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202214094

Current Developments in Antibiotic Discovery – Global Microbial Diversity as Source for Evolutionary Optimized Anti-infectives

Hegemann J, Birkelbach J, Walesch S, Müller R (2022)

EMBO Rep. published concurrently

Large-Scale Interlaboratory DI-FT-ICR MS Comparability Study Employing Various Systems

Forcisi S, Moritz F, Thompson C, Kanawati B, Uhl J, Afonso C, Bader C, Barsch A, Boughton B, Chu R, …, Laukien F, Schmitt-Kopplin P (2022)

Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.2c00082

Total synthesis of Myxoprincomide, a secondary metabolite from Myxococcus xanthus

Kohr M, Walt C, Dastbaz J, Müller R, Kazmaier U (2022)

Org. Biomol. Chem.DOI: 10.1039/d2ob02021a

Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening

Di Zhu, Johannsen S, Masini T, Simonin C, Haupenthal J, Illarionov B, Andreas A, Awale M, Gierse R, van der Laan T, …, Reymond J, Hirsch A (2022)

Chem. Sci. 13 (36): 10686-10698DOI: 10.1039/D2SC02371G

Thiamyxins: Structure and Biosynthesis of Myxobacterial RNA-Virus Inhibitors

Haack P, Harmrolfs K, Bader C, Garcia R, Gunesch A, Haid S, Popoff A, Voltz A, Kim H, Bartenschlager R, Pietschmann T, Müller R (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202212946

Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin

Couturier C, Groß S, Tesmar A, Hoffmann J, Deckarm S, Fievet A, Dubarry N, Taillier T, Pöverlein C, Stump H, …, Müller R, Renard S (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202210747

BusyBee Web: towards comprehensive and differential composition-based metagenomic binning

Schmartz G, Hirsch P, Amand J, Dastbaz J, Fehlmann T, Kern F, Müller R, Keller A (2022)

Nucleic Acids ResDOI: 10.1093/nar/gkac298

The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB

Camberlein V, Jézéquel G, Haupenthal J, Hirsch A (2022)

Antibiotics 11 (8)DOI: 10.3390/antibiotics11081060

Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism

Chen F, Elgaher W, Winterhoff M, Büssow K, Waqas F, Graner E, Pires-Afonso Y, Casares Perez L, La Vega L, Sahini N, …, Hirsch A, Pessler F (2022)

Nature metabolism 4 (5): 534-546DOI: 10.1038/s42255-022-00577-x

Regio- and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives

Müller R, Hofer W, Oueis E, Abou Fayad A, Deschner F, Andreas A, Carvalho L, Hüttel S, Bernecker S, Pätzold L, …, Held J, Herrmann J (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202202816

Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors

Wimmer S, Hoff K, Martin B, Grewer M, Denni L, Lascorz Massanet R, Raimondi M, Bülbül E, Melesina J, Hotop S, …, Sippl W, Holl R (2022)

Bioorganic chemistry 131DOI: 10.1016/j.bioorg.2022.106331

Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape

Lee S, Nasr S, Rasheed S, Liu Y, Hartwig O, Kaya C, Boese A, Koch M, Herrmann J, Müller R, …, Hirsch A, Lehr C (2022)

Journal of controlled release : official journal of the Controlled Release Society 353: 915-929DOI: 10.1016/j.jconrel.2022.12.018

Current Developments in Antibiotic Discovery – Global Microbial Diversity as Source for Evolutionary Optimized Anti-infectives

Hegemann J, Birkelbach J, Walesch S, Müller R (2022)

EMBO Rep. published concurrently

Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation

Ibrahim A, Abdel Gaber S, Fawzi Kabil M, Ahmed-Farid O, Hirsch A, El-Sherbiny I, Nasr M (2022)

Expert Opin. Drug Deliv. 19 (11): 1549-1560DOI: 10.1080/17425247.2022.2139370

Introduction to themed collection on fragment-based drug discovery

Rees D, Hirsch A, Erlanson D (2022)

RSC Med. Chem. 13DOI: 10.1039/D2MD90037H

The chemical ecology of the fungus-farming termite symbiosis

Schmidt S, Kildgaard S, Guo H, Beemelmanns C, Poulsen M (2022)

Nat. Prod. Rep. 39 (2): 231-248DOI: 10.1039/d1np00022e

A Modular Approach to the Antifungal Sphingofungin Family: Concise Total Synthesis of Sphingofungin A and C

Raguž L, Peng C, Kaiser M, Görls H, Beemelmanns C (2022)

Angewandte Chemie (International ed. in English) 61 (5)DOI: 10.1002/anie.202112616

Structural and Functional Analysis of Bacterial Sulfonosphingolipids and Rosette-Inducing Factor 2 (RIF-2) by Mass Spectrometry-Guided Isolation and Total Synthesis

Leichnitz D, Peng C, Raguž L, Rutaganira F, Jautzus T, Regestein L, King N, Beemelmanns C (2022)

Chem. Eur. J. 28 (8)DOI: 10.1002/chem.202103883

Signalling molecules inducing metamorphosis in marine organisms

Rischer M, Guo H, Beemelmanns C (2022)

Nat. Prod. Rep. 39 (9): 1833-1855DOI: 10.1039/d1np00073j

Application of pyrrolo-protected amino aldehydes in the stereoselective synthesis of anti-1,2-amino alcohols

Sauer M, Beemelmanns C (2022)

Chemical communications (Cambridge, England) 58 (64): 8990-8993DOI: 10.1039/d2cc02317b

Identification of the new prenyltransferase Ubi-297 from marine bacteria and elucidation of its substrate specificity

Amiri Moghaddam J, Guo H, Willing K, Wichard T, Beemelmanns C (2022)

Beilstein journal of organic chemistry 18: 722-731DOI: 10.3762/bjoc.18.72

GNPS-Guided Discovery of Madurastatin Siderophores from the Termite-Associated Actinomadura sp. RB99

Lee S, Schalk F, Schwitalla J, Guo H, Yu J, Song M, Jung W, Beer Z, Beemelmanns C, Kim K (2022)

Chem. Eur. J. 28 (36)DOI: 10.1002/chem.202200612

Comparative Genomic and Metabolomic Analysis of Termitomyces Species Provides Insights into the Terpenome of the Fungal Cultivar and the Characteristic Odor of the Fungus Garden of Macrotermes natalensis Termites

Kreuzenbeck N, Seibel E, Schwitalla J, Fricke J, Conlon B, Schmidt S, Hammerbacher A, Köllner T, Poulsen M, Hoffmeister D, Beemelmanns C (2022)

mSystems 7 (1)DOI: 10.1128/msystems.01214-21

Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition

Hoefgen S, Bissell A, Huang Y, Gherlone F, Raguž L, Beemelmanns C, Valiante V (2022)

Microbiology Spectrum 10 (5)DOI: 10.1128/spectrum.01331-22

Insights into the Metabolomic Capacity of Podaxis and Isolation of Podaxisterols A-D, Ergosterol Derivatives Carrying Nitrosyl Cyanide-Derived Modifications

Guo H, Daniel J, Seibel E, Burkhardt I, Conlon B, Görls H, Vassão D, Dickschat J, Poulsen M, Beemelmanns C (2022)

Journal of natural products 85 (9): 2159-2167DOI: 10.1021/acs.jnatprod.2c00380

Synthesis of Functionalized δ-Hydroxy-β-keto Esters and Evaluation of Their Anti-inflammatory Properties

Grosse M, Günther K, Jordan P, Roman D, Werz O, Beemelmanns C (2022)

Chembiochem : a European journal of chemical biology 23 (9)DOI: 10.1002/cbic.202200073

Biosynthesis of the Sphingolipid Inhibitors Sphingofungins in Filamentous Fungi Requires Aminomalonate as a Metabolic Precursor

Bissell A, Rautschek J, Hoefgen S, Raguž L, Mattern D, Saeed N, Janevska S, Jojic K, Huang Y, Kufs J, …, Beemelmanns C, Valiante V (2022)

ACS chemical biology 17 (2): 386-394DOI: 10.1021/acschembio.1c00839

The inherent antibiotic activity of myxobacteria-derived autofluorescent outer membrane vesicles is switched on and off by light stimulation

Lapuhs P, Heinrich E, Garcia R, Goes A, Frank N, Bollenbach L, Stibane V, Kuhn T, Koch M, Kiemer A, …, Fuhrmann K, Fuhrmann G (2022)

NanoscaleDOI: 10.1039/d2nr02743g

Targeting undruggable carbohydrate recognition sites through focused fragment library design

Shanina E, Kuhaudomlarp S, Siebs E, Fuchsberger F, Denis M, da Silva Figueiredo Celestino Gomes P, Clausen M, Seeberger P, Rognan D, Titz A, Imberty A, Rademacher C (2022)

Commun Chem 5 (1): 1-11DOI: 10.1038/s42004-022-00679-3

NamZ1 and NamZ2 from the Oral Pathogen Tannerella forsythia Are Peptidoglycan Processing Exo-β-N-Acetylmuramidases with Distinct Substrate Specificities

Borisova M, Balbuchta K, Lovering A, Titz A, Mayer C (2022)

J. Bacteriol. 204 (3)DOI: 10.1128/jb.00597-21

Targeting the Central Pocket of the Pseudomonas aeruginosa Lectin LecA

Siebs E, Shanina E, Kuhaudomlarp S, da Silva Figueiredo Celestino Gomes P, Fortin C, Seeberger P, Rognan D, Rademacher C, Imberty A, Titz A (2022)

Chembiochem : a European journal of chemical biology 23 (3)DOI: 10.1002/cbic.202100563

β-Boronic Acid-Substituted Bodipy Dyes for Fluorescence Anisotropy Analysis of Carbohydrate Binding

Hoffmann C, Jourdain M, Grandjean A, Titz A, Jung G (2022)

Analytical chemistry 94 (16): 6112-6119DOI: 10.1021/acs.analchem.1c04654

Pineapple Lectin AcmJRL binds SARS-CoV-2 Spike Protein in a carbohydrate-dependent fashion

Meiers J, Dastbaz J, Adam S, Rasheed S, Kirsch S, Meiser P, Gross P, Müller R, Titz A (2022)

Chembiochem : a European journal of chemical biologyDOI: 10.1002/cbic.202200463

The Glycan-Specificity of the Pineapple Lectin AcmJRL and its Carbohydrate-Dependent Binding of the SARS-CoV-2 Spike Protein

Meiers J, Dastbaz J, Adam S, Rasheed S, Kirsch S, Meiser P, Gross P, Müller R, Titz A (2022)

BookDOI: 10.1101/2022.05.27.493400

Lectin-Targeted Prodrugs Activated by Pseudomonas aeruginosa for Self-Destructive Antibiotic Release

Meiers J, Rox K, Titz A (2022)

Journal of medicinal chemistry 65 (20): 13988-14014DOI: 10.1021/acs.jmedchem.2c01214

Neutralizing the Impact of the Virulence Factor LecA from Pseudomonas aeruginosa on Human Cells with New Glycomimetic Inhibitors

Zahorska E, Rosato F, Stober K, Kuhaudomlarp S, Meiers J, Hauck D, Reith D, Gillon E, Rox K, Imberty A, Römer W, Titz A (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202215535

Discovery of N-β-l-Fucosyl Amides as High-Affinity Ligands for the Pseudomonas aeruginosa Lectin LecB

Mala P, Siebs E, Meiers J, Rox K, Varrot A, Imberty A, Titz A (2022)

Journal of medicinal chemistry 65 (20): 14180-14200DOI: 10.1021/acs.jmedchem.2c01373

An Efficient Way to Screen Inhibitors of Energy-Coupling Factor (ECF) Transporters in a Bacterial Uptake Assay

Bousis S, Winkler S, Haupenthal J, Fulco F, Diamanti E, Hirsch A (2022)

International journal of molecular sciences 23 (5)DOI: 10.3390/ijms23052637

Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages

Sake S, Kosch C, Blockus S, Haid S, Gunesch A, Zhang X, Friesland M, Trummer S, Grethe C, Kühnel A, …, Schulz T, Pietschmann T (2022)

Antimicrobial agents and chemotherapyDOI: 10.1128/aac.01032-22

Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases

Alhayek A, Abdelsamie A, Schönauer E, Camberlein V, Hutterer E, Posselt G, Serwanja J, Blöchl C, Huber C, Haupenthal J, …, Wessler S, Hirsch A (2022)

Journal of medicinal chemistry 65 (19): 12933-12955DOI: 10.1021/acs.jmedchem.2c00785

Expanding the Ajudazol Cytotoxin Scaffold: Insights from Genome Mining, Biosynthetic Investigations, and Novel Derivatives

Zeng H, Birkelbach J, Hoffmann J, Popoff A, Volz C, Müller R (2022)

Journal of natural productsDOI: 10.1021/acs.jnatprod.2c00637

Interference with lipoprotein maturation sensitizes methicillin-resistant Staphylococcus aureus to human group IIA secreted phospholipase A 2 and daptomycin

Kuijk M, Wu Y, van Hensbergen V, Shanlitourk G, Payré C, Lambeau G, Herrmann J, Müller R, van Strijp J, Pannekoek Y, Touqui L, van Sorge N (2022)

BookDOI: 10.1101/2022.02.06.476181

Natural products lysobactin and sorangicin A show in vitro activity against Mycobacterium abscessus complex

Sullivan J, Yao J, Courtine C, Lupien A, Herrmann J, Müller R, Behr M (2022)

BookDOI: 10.1101/2022.06.27.497873

Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA

Fathalla R, Fröhner W, Bader C, Fischer P, Dahlem C, Chatterjee D, Mathea S, Kiemer A, Arthanari H, Müller R, …, Ducho C, Engel M (2022)

Journal of medicinal chemistryDOI: 10.1021/acs.jmedchem.2c01275

Pharmacology and early ADMET data of corallopyronin A, a natural product with macrofilaricidal anti-wolbachial activity in filarial nematodes

Ehrens A, Schiefer A, Krome A, Becker T, Rox K, Neufeld H, Aden T, Wagner K, Müller R, Grosse M, …, Pfarr K, Hoerauf A (2022)

Front. Trop. Dis 3DOI: 10.3389/fitd.2022.983107

A novel tumor-targeting strain of Xenorhabdus stockiae exhibits potent biological activities

Zhang C, Chen H, Hüttel S, Hu S, Zhang W, Ding X, Yin J, Yin Y, Müller R, Xia L, Zhang Y, Tu Q (2022)

Frontiers in Bioengineering and Biotechnology 10DOI: 10.3389/fbioe.2022.984197

Discovery, Biosynthesis and Biological Activity of a Succinylated Myxochelin from the Myxobacterial strain MSr12020

Okoth D, Hug J, Garcia R, Müller R (2022)

BookDOI: 10.20944/preprints202209.0147.v1

Leaky gut model of the human intestinal mucosa for testing siRNA-based nanomedicine targeting JAK1

Hartwig O, Loretz B, Nougarede A, Jary D, Sulpice E, Gidrol X, Navarro F, Lehr C (2022)

J Control Release 345: 646-660DOI: 10.1016/j.jconrel.2022.03.037

NPvis: An Interactive Visualizer of Peptidic Natural Product-MS/MS Matches

Kunyavskaya O, Mikheenko A, Gurevich A (2022)

Metabolites 12 (8)DOI: 10.3390/metabo12080706

Total Synthesis and Functional Evaluation of IORs, Sulfonolipid-based Inhibitors of Cell Differentiation in Salpingoeca rosetta

Raguž L, Peng C, Rutaganira F, Krüger T, Stanišic A, Jautzus T, Kries H, Kniemeyer O, Brakhage A, King N, Beemelmanns C (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202209105

Discovery of a Unique Structural Motif in Lanthipeptide Synthetases for Substrate Binding and Interdomain Interactions

Huang S, Wang Y, Cai C, Xiao X, Liu S, Ma Y, Xie X, Liang Y, Chen H, Zhu J, …, Wei W, Wang H (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202211382

Screening of Natural Products and Small Molecules Uncovers Novel Coronavirus 1a/1b Frameshifting Inhibitors with Antiviral Properties

Kibe A, Elgaher W, Rand U, Zimmer M, Kany A, Hermann J, Müller R, Cicin-Sain L, Hirsch A, Caliskan N (2022)

SSRN JournalDOI: 10.2139/ssrn.4157446

Design, Synthesis, Antimicrobial Activity, and Molecular Docking of Some New Diclofenac Derivatives

Tolba M, Hamed M, Sayed M, Kamal El-Dean A, Abdel-Mohsen S, Ibrahim O, Elgaher W, Hirsch A, Saddik A (2022)

Polycyclic Aromatic Compounds: 1-16DOI: 10.1080/10406638.2022.2102661

Structural analysis of 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding

Hamid R, Adam S, Lacour A, Gomez L, Hirsch A (2022)

bioRxivDOI: 10.1101/2022.07.04.498669

Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry

Bagnolini G, Balboni B, Schipani F, Gioia D, Veronesi M, Franco F, Kaya C, Jumde R, Ortega J, Girotto S, …, Roberti M, Cavalli A (2022)

ACS Med. Chem. Lett. 13 (8): 1262-1269DOI: 10.1021/acsmedchemlett.2c00063

Systematic cross-biospecimen evaluation of DNA extraction kits for long- and short-read multi-metagenomic sequencing studies

Rehner J, Schmartz G, Groeger L, Dastbaz J, Ludwig N, Hannig M, Rupf S, Seitz B, Flockerzi E, Berger T, …, Keller A, Müller R (2022)

Genomics Proteomics BioinformaticsDOI: 10.1016/j.gpb.2022.05.006

Three New Stigmatellin Derivatives Reveal Biosynthetic Insights of Its Side Chain Decoration

Okoth D, Hug J, Garcia R, Müller R (2022)

Molecules (Basel, Switzerland) 27 (14)DOI: 10.3390/molecules27144656

Corallopyronin A: antimicrobial discovery to preclinical development

Krome A, Becker T, Kehraus S, Schiefer A, Gütschow M, Chaverra-Muñoz L, Hüttel S, Jansen R, Stadler M, Ehrens A, …, Wagner K, König G (2022)

Nat. Prod. Rep.DOI: 10.1039/d2np00012a

Corallococcus soli sp. Nov., a Soil Myxobacterium Isolated from Subtropical Climate, Chalus County, Iran, and Its Potential to Produce Secondary Metabolites

Babadi Z, Garcia R, Ebrahimipour G, Risdian C, Kämpfer P, Jarek M, Müller R, Wink J (2022)

Microorganisms 10 (7)DOI: 10.3390/microorganisms10071262

Themed issue: Extracellular vesicles in drug delivery and bioengineering

Fuhrmann G, Lehr C, Schiffelers R (2022)

Advanced Drug Delivery Reviews 181DOI: 10.1016/j.addr.2021.114073

Nano-in-Microparticles for Aerosol Delivery of Antibiotic-Loaded, Fucose-Derivatized, and Macrophage-Targeted Liposomes to Combat Mycobacterial Infections: In Vitro Deposition, Pulmonary Barrier Interactions, and Targeted Delivery

Huck B, Thiyagarajan D, Bali A, Boese A, Besecke K, Hozsa C, Gieseler R, Furch M, Carvalho-Wodarz C, Waldow F, …, Loretz B, Lehr C (2022)

Advanced healthcare materials 11 (11)DOI: 10.1002/adhm.202102117

Transferring Microclusters of P. aeruginosa Biofilms to the Air-Liquid Interface of Bronchial Epithelial Cells for Repeated Deposition of Aerosolized Tobramycin

Horstmann J, Laric A, Boese A, Yildiz D, Röhrig T, Empting M, Frank N, Krug D, Müller R, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2022)

ACS infectious diseases 8 (1): 137-149DOI: 10.1021/acsinfecdis.1c00444

Spray-dried pneumococcal membrane vesicles are promising candidates for pulmonary immunization

Mehanny M, Boese A, Bornamehr B, Hoppstädter J, Presser V, Kiemer A, Lehr C, Fuhrmann G (2022)

International journal of pharmaceutics 621DOI: 10.1016/j.ijpharm.2022.121794

Targeting extracellular lectins of Pseudomonas aeruginosa with glycomimetic liposomes

Metelkina O, Huck B, O'Connor J, Koch M, Manz A, Lehr C, Titz A (2022)

Journal of Materials Chemistry B 10 (4): 537-548DOI: 10.1039/d1tb02086b

An Outer Membrane Vesicle-Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability

Richter R, Kamal M, Koch M, Niebuur B, Huber A, Goes A, Volz C, Vergalli J, Kraus T, Müller R, …, Pagès J, Lehr C (2022)

Advanced healthcare materials 11 (5)DOI: 10.1002/adhm.202101180

Exploring the permeation of fluoroquinolone metalloantibiotics across outer membrane porins by combining molecular dynamics simulations and a porin-mimetic in vitro model

Sousa C, Coimbra J, Richter R, Morais-Cabral J, Ramos M, Lehr C, Fernandes P, Gameiro P (2022)

Biochimica et biophysica acta. Biomembranes 1864 (3)DOI: 10.1016/j.bbamem.2021.183838

Yields and Immunomodulatory Effects of Pneumococcal Membrane Vesicles Differ with the Bacterial Growth Phase

Mehanny M, Kroniger T, Koch M, Hoppstädter J, Becher D, Kiemer A, Lehr C, Fuhrmann G (2022)

Advanced healthcare materials 11 (5)DOI: 10.1002/adhm.202101151

Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: Composition, structure and barrier properties

Huck B, Murgia X, Frisch S, Hittinger M, Hidalgo A, Loretz B, Lehr C (2022)

Advanced Drug Delivery Reviews 183DOI: 10.1016/j.addr.2022.114141

Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters

Kiefer A, Bousis S, Hamed M, Diamanti E, Haupenthal J, Hirsch A (2022)

J. Med. Chem.DOI: 10.1021/acs.jmedchem.1c02114

Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents

Kaya C, Hirsch A (2022)

Chimia 76 (5)DOI: 10.2533/chimia.2022.402

Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors

Hamdy J, Emadeldin N, Hamed M, Frakolaki E, Katsamakas S, Vassilaki N, Zoidis G, Hirsch A, Abdel-Halim M, Abadi A (2022)

Pharmaceuticals 15 (5)DOI: 10.3390/ph15050632

First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

Gierse R, Oerlemans R, Reddem E, Gawriljuk V, Alhayek A, Baitinger D, Jakobi H, Laber B, Lange G, Hirsch A, Groves M (2022)

Sci. Rep. 12 (1)DOI: 10.1038/s41598-022-11205-9

Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi

Kirsch S, Haeckl F, Müller R (2022)

Nat. Prod. Rep.DOI: 10.1039/d1np00067e

N-Aryl-2-iso-butylmercaptoacetamides: the discovery of highly potent and selective inhibitors of Pseudomonas aeruginosa virulence factor LasB and Clostridium histolyticum virulence factor ColH

Voos K, Yahiaoui S, Konstantinovic J, Schönauer E, Alhayek A, Sikandar A, Si Chaib K, Ramspoth T, Rox K, Haupenthal J, …, Ducho C, Hirsch A (2022)

ChemRxivDOI: 10.26434/chemrxiv-2022-fjrqr

Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa

Kaya C, Walter I, Alhayek A, Shafiei R, Jézéquel G, Andreas A, Konstantinovic J, Schönauer E, Sikandar A, Haupenthal J, …, Hartmann R, Hirsch A (2022)

ACS Infect. Dis.DOI: 10.1021/acsinfecdis.1c00628

Induction of Liver Size Reduction in Zebrafish Larvae by the Emerging Synthetic Cannabinoid 4F-MDMB-BINACA and Its Impact on Drug Metabolism

Park Y, Dahlem C, Meyer M, Kiemer A, Müller R, Herrmann J (2022)

Molecules (Basel, Switzerland) 27 (4)DOI: 10.3390/molecules27041290

N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases

Kaya C, Konstantinovic J, Kany A, Andreas A, Kramer J, Brunst S, Weizel L, Rotter M, Frank D, Yahiaoui S, …, Wichelhaus T, Hirsch A (2022)

Journal of medicinal chemistry 65 (5): 3913-3922DOI: 10.1021/acs.jmedchem.1c01755

Myxobacteria of the Cystobacterineae Suborder Are Producers of New Vitamin K2 Derived Myxoquinones

Panter F, Popoff A, Garcia R, Krug D, Müller R (2022)

Microorganisms 10 (3)DOI: 10.3390/microorganisms10030534

PLSDB: advancing a comprehensive database of bacterial plasmids

Schmartz G, Hartung A, Hirsch P, Kern F, Fehlmann T, Müller R, Keller A (2022)

Nucleic Acids Res 50 (D1): 273-DOI: 10.1093/nar/gkab1111

Metabolic profiling of S-praziquantel: Structure elucidation using the crystalline sponge method in combination with mass spectrometry and nuclear magnetic resonance

Rosenberger L, Jenniches J, Essen C, Khutia A, Kühn C, Marx A, Georgi K, Hirsch A, Hartmann R, Badolo L (2022)

Drug metabolism and disposition: the biological fate of chemicalsDOI: 10.1124/dmd.121.000663

Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part

Megahed S, Rasheed S, Herrmann J, El-Hossary E, El-Shabrawy Y, Abadi A, Engel M, Müller R, Abdel-Halim M, Hamed M (2022)

Bioorg Med Chem Lett 59DOI: 10.1016/j.bmcl.2022.128531

New Deoxyenhygrolides from Plesiocystis pacifica Provide Insights into Butenolide Core Biosynthesis

Hug J, Kjaerulff L, Garcia R, Müller R (2022)

Marine drugs 20 (1)DOI: 10.3390/md20010072

Sandacrabins - Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium

Bader C, Panter F, Garcia R, Tchesnokov E, Haid S, Walt C, Spröer C, Kiefer A, Götte M, Overmann J, Pietschmann T, Müller R (2022)

Chem. Eur. J. 28 (10)DOI: 10.1002/chem.202104484

Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin‐Wound Infections

Alhayek A, Khan E, Schönauer E, Däinghaus T, Shafiei R, Voos K, Han M, Ducho C, Posselt G, Wessler S, …, del Campo A, Hirsch A (2022)

Adv. Therap.DOI: 10.1002/adtp.202100222

Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor

Drost M, Diamanti E, Fuhrmann K, Goes A, Shams A, Haupenthal J, Koch M, Hirsch A, Fuhrmann G (2022)

Pharmaceutics 14 (1)DOI: 10.3390/pharmaceutics14010004

Biotechnological production optimization of argyrins - a potent immunomodulatory natural product class

Pogorevc D, Müller R (2022)

Microbial Biotechnology 15 (1): 353-369DOI: 10.1111/1751-7915.13959