Publications
Publication Highlights
Have a look at our latest discoveries.
Publication database
2022
Regio- and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives
Müller R, Hofer W, Oueis E, Abou Fayad A, Deschner F, Andreas A, Carvalho L, Hüttel S, Bernecker S, Pätzold L, …, Held J, Herrmann J (2022)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202202816
Systematic cross-biospecimen evaluation of DNA extraction kits for long- and short-read multi-metagenomic sequencing studies
Rehner J, Schmartz G, Groeger L, Dastbaz J, Ludwig N, Hannig M, Rupf S, Seitz B, Flockerzi E, Berger T, …, Keller A, Müller R (2022)
Genomics Proteomics BioinformaticsDOI: 10.1016/j.gpb.2022.05.006
Three New Stigmatellin Derivatives Reveal Biosynthetic Insights of Its Side Chain Decoration
Okoth D, Hug J, Garcia R, Müller R (2022)
Molecules (Basel, Switzerland) 27 (14)DOI: 10.3390/molecules27144656
Corallopyronin A: antimicrobial discovery to preclinical development
Krome A, Becker T, Kehraus S, Schiefer A, Gütschow M, Chaverra-Muñoz L, Hüttel S, Jansen R, Stadler M, Ehrens A, …, Wagner K, König G (2022)
Nat. Prod. Rep.DOI: 10.1039/d2np00012a
Corallococcus soli sp. Nov., a Soil Myxobacterium Isolated from Subtropical Climate, Chalus County, Iran, and Its Potential to Produce Secondary Metabolites
Babadi Z, Garcia R, Ebrahimipour G, Risdian C, Kämpfer P, Jarek M, Müller R, Wink J (2022)
Microorganisms 10 (7)DOI: 10.3390/microorganisms10071262
Themed issue: Extracellular vesicles in drug delivery and bioengineering
Fuhrmann G, Lehr C, Schiffelers R (2022)
Advanced Drug Delivery Reviews 181DOI: 10.1016/j.addr.2021.114073
Spray-dried pneumococcal membrane vesicles are promising candidates for pulmonary immunization
Mehanny M, Boese A, Bornamehr B, Hoppstädter J, Presser V, Kiemer A, Lehr C, Fuhrmann G (2022)
International journal of pharmaceutics 621DOI: 10.1016/j.ijpharm.2022.121794
Targeting extracellular lectins of Pseudomonas aeruginosa with glycomimetic liposomes
Metelkina O, Huck B, O'Connor J, Koch M, Manz A, Lehr C, Titz A (2022)
Journal of Materials Chemistry B 10 (4): 537-548DOI: 10.1039/d1tb02086b
Nano-in-Microparticles for Aerosol Delivery of Antibiotic-Loaded, Fucose-Derivatized, and Macrophage-Targeted Liposomes to Combat Mycobacterial Infections: In Vitro Deposition, Pulmonary Barrier Interactions, and Targeted Delivery
Huck B, Thiyagarajan D, Bali A, Boese A, Besecke K, Hozsa C, Gieseler R, Furch M, Carvalho-Wodarz C, Waldow F, …, Loretz B, Lehr C (2022)
Advanced healthcare materials 11 (11)DOI: 10.1002/adhm.202102117
An Outer Membrane Vesicle-Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability
Richter R, Kamal M, Koch M, Niebuur B, Huber A, Goes A, Volz C, Vergalli J, Kraus T, Müller R, …, Pagès J, Lehr C (2022)
Advanced healthcare materials 11 (5)DOI: 10.1002/adhm.202101180
Yields and Immunomodulatory Effects of Pneumococcal Membrane Vesicles Differ with the Bacterial Growth Phase
Mehanny M, Kroniger T, Koch M, Hoppstädter J, Becher D, Kiemer A, Lehr C, Fuhrmann G (2022)
Advanced healthcare materials 11 (5)DOI: 10.1002/adhm.202101151
Exploring the permeation of fluoroquinolone metalloantibiotics across outer membrane porins by combining molecular dynamics simulations and a porin-mimetic in vitro model
Sousa C, Coimbra J, Richter R, Morais-Cabral J, Ramos M, Lehr C, Fernandes P, Gameiro P (2022)
Biochimica et biophysica acta. Biomembranes 1864 (3)DOI: 10.1016/j.bbamem.2021.183838
Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: Composition, structure and barrier properties
Huck B, Murgia X, Frisch S, Hittinger M, Hidalgo A, Loretz B, Lehr C (2022)
Advanced Drug Delivery Reviews 183DOI: 10.1016/j.addr.2022.114141
Leaky gut model of the human intestinal mucosa for testing siRNA-based nanomedicine targeting JAK1
Hartwig O, Loretz B, Nougarede A, Jary D, Sulpice E, Gidrol X, Navarro F, Lehr C (2022)
Journal of controlled release : official journal of the Controlled Release Society 345: 646-660DOI: 10.1016/j.jconrel.2022.03.037
Transferring Microclusters of P. aeruginosa Biofilms to the Air-Liquid Interface of Bronchial Epithelial Cells for Repeated Deposition of Aerosolized Tobramycin
Horstmann J, Laric A, Boese A, Yildiz D, Röhrig T, Empting M, Frank N, Krug D, Müller R, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2022)
ACS infectious diseases 8 (1): 137-149DOI: 10.1021/acsinfecdis.1c00444
Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters
Kiefer A, Bousis S, Hamed M, Diamanti E, Haupenthal J, Hirsch A (2022)
J. Med. Chem.DOI: 10.1021/acs.jmedchem.1c02114
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism
Chen F, Elgaher W, Winterhoff M, Büssow K, Waqas F, Graner E, Pires-Afonso Y, Casares Perez L, La Vega L, Sahini N, …, Hirsch A, Pessler F (2022)
Nature metabolism 4 (5): 534-546DOI: 10.1038/s42255-022-00577-x
Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents
Kaya C, Hirsch A (2022)
Chimia 76 (5)DOI: 10.2533/chimia.2022.402
Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening
Zhu D, Johannsen S, Masini T, Simonin C, Haupenthal J, Illarionov B, Andreas A, Awale M, Gierse R, van der Laan T, …, Reymond J, Hirsch A (2022)
ChemRxivDOI: 10.26434/chemrxiv-2022-73fb5-v2
Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors
Hamdy J, Emadeldin N, Hamed M, Frakolaki E, Katsamakas S, Vassilaki N, Zoidis G, Hirsch A, Abdel-Halim M, Abadi A (2022)
Pharmaceuticals 15 (5)DOI: 10.3390/ph15050632
First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization
Gierse R, Oerlemans R, Reddem E, Gawriljuk V, Alhayek A, Baitinger D, Jakobi H, Laber B, Lange G, Hirsch A, Groves M (2022)
Sci. Rep. 12 (1)DOI: 10.1038/s41598-022-11205-9
Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi
Kirsch S, Haeckl F, Müller R (2022)
Nat. Prod. Rep.DOI: 10.1039/d1np00067e
N-Aryl-2-iso-butylmercaptoacetamides: the discovery of highly potent and selective inhibitors of Pseudomonas aeruginosa virulence factor LasB and Clostridium histolyticum virulence factor ColH
Voos K, Yahiaoui S, Konstantinovic J, Schönauer E, Alhayek A, Sikandar A, Si Chaib K, Ramspoth T, Rox K, Haupenthal J, …, Ducho C, Hirsch A (2022)
ChemRxivDOI: 10.26434/chemrxiv-2022-fjrqr
Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa
Kaya C, Walter I, Alhayek A, Shafiei R, Jézéquel G, Andreas A, Konstantinovic J, Schönauer E, Sikandar A, Haupenthal J, …, Hartmann R, Hirsch A (2022)
ACS Infect. Dis.DOI: 10.1021/acsinfecdis.1c00628
Induction of Liver Size Reduction in Zebrafish Larvae by the Emerging Synthetic Cannabinoid 4F-MDMB-BINACA and Its Impact on Drug Metabolism
Park Y, Dahlem C, Meyer M, Kiemer A, Müller R, Herrmann J (2022)
Molecules (Basel, Switzerland) 27 (4)DOI: 10.3390/molecules27041290
N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases
Kaya C, Konstantinovic J, Kany A, Andreas A, Kramer J, Brunst S, Weizel L, Rotter M, Frank D, Yahiaoui S, …, Wichelhaus T, Hirsch A (2022)
Journal of medicinal chemistry 65 (5): 3913-3922DOI: 10.1021/acs.jmedchem.1c01755
Myxobacteria of the Cystobacterineae Suborder Are Producers of New Vitamin K2 Derived Myxoquinones
Panter F, Popoff A, Garcia R, Krug D, Müller R (2022)
Microorganisms 10 (3)DOI: 10.3390/microorganisms10030534
PLSDB: advancing a comprehensive database of bacterial plasmids
Schmartz G, Hartung A, Hirsch P, Kern F, Fehlmann T, Müller R, Keller A (2022)
Nucleic Acids Res 50 (D1): 273-DOI: 10.1093/nar/gkab1111
Metabolic profiling of S-praziquantel: Structure elucidation using the crystalline sponge method in combination with mass spectrometry and nuclear magnetic resonance
Rosenberger L, Jenniches J, Essen C, Khutia A, Kühn C, Marx A, Georgi K, Hirsch A, Hartmann R, Badolo L (2022)
Drug metabolism and disposition: the biological fate of chemicalsDOI: 10.1124/dmd.121.000663
Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part
Megahed S, Rasheed S, Herrmann J, El-Hossary E, El-Shabrawy Y, Abadi A, Engel M, Müller R, Abdel-Halim M, Hamed M (2022)
Bioorg Med Chem Lett 59DOI: 10.1016/j.bmcl.2022.128531
New Deoxyenhygrolides from Plesiocystis pacifica Provide Insights into Butenolide Core Biosynthesis
Hug J, Kjaerulff L, Garcia R, Müller R (2022)
Marine drugs 20 (1)DOI: 10.3390/md20010072
Sandacrabins - Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium
Bader C, Panter F, Garcia R, Tchesnokov E, Haid S, Walt C, Spröer C, Kiefer A, Götte M, Overmann J, Pietschmann T, Müller R (2022)
Chem. Eur. J. 28 (10)DOI: 10.1002/chem.202104484
Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin‐Wound Infections
Alhayek A, Khan E, Schönauer E, Däinghaus T, Shafiei R, Voos K, Han M, Ducho C, Posselt G, Wessler S, …, del Campo A, Hirsch A (2022)
Adv. Therap.DOI: 10.1002/adtp.202100222
Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor
Drost M, Diamanti E, Fuhrmann K, Goes A, Shams A, Haupenthal J, Koch M, Hirsch A, Fuhrmann G (2022)
Pharmaceutics 14 (1)DOI: 10.3390/pharmaceutics14010004
Biotechnological production optimization of argyrins - a potent immunomodulatory natural product class
Pogorevc D, Müller R (2022)
Microbial Biotechnology 15 (1): 353-369DOI: 10.1111/1751-7915.13959
2021
Improved broad-spectrum antibiotics against Gram-negative pathogens via darobactin biosynthetic pathway engineering
Groß S, Panter F, Pogorevc D, Seyfert C, Deckarm S, Bader C, Herrmann J, Müller R (2021)
Chem. Sci. 12 (35): 11882-11893DOI: 10.1039/d1sc02725e
In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
Groß S, Schnell B, Haack P, Auerbach D, Müller R (2021)
Nat Commun 12 (1)DOI: 10.1038/s41467-021-21848-3
The Sandarazols are Cryptic and Structurally Unique Plasmid-Encoded Toxins from a Rare Myxobacterium*
Panter F, Bader C, Müller R (2021)
Angewandte Chemie (International ed. in English) 60 (15): 8081-8088DOI: 10.1002/anie.202014671
Towards the sustainable discovery and development of new antibiotics
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo P, Glaser P, Aigle B, Bode H, …, Moser H, Müller R (2021)
Nature reviews. Chemistry 5 (10): 726-749DOI: 10.1038/s41570-021-00313-1
Co-Delivery of mRNA and pDNA Using Thermally Stabilized Coacervate-Based Core-Shell Nanosystems
Nasr S, Lee S, Thiyagarajan D, Boese A, Loretz B, Lehr C (2021)
Pharmaceutics 13 (11)DOI: 10.3390/pharmaceutics13111924
Pulmonary in vitro instruments for the replacement of animal experiments
Primavessy D, Metz J, Schnur S, Schneider M, Lehr C, Hittinger M (2021)
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 168: 62-75DOI: 10.1016/j.ejpb.2021.08.005
A pulmonary mucus surrogate for investigating antibiotic permeation and activity against Pseudomonas aeruginosa biofilms
Frisch S, Boese A, Huck B, Horstmann J, Ho D, Schwarzkopf K, Murgia X, Loretz B, Souza Carvalho-Wodarz C, Lehr C (2021)
The Journal of antimicrobial chemotherapy 76 (6): 1472-1479DOI: 10.1093/jac/dkab068
Surfactant-Free Glibenclamide Nanoparticles: Formulation, Characterization and Evaluation of Interactions with Biological Barriers
Arrua E, Hartwig O, Ho D, Loretz B, Murgia X, Salomon C, Lehr C (2021)
Pharmaceutical research 38 (6): 1081-1092DOI: 10.1007/s11095-021-03056-2
PerfuPul-A Versatile Perfusable Platform to Assess Permeability and Barrier Function of Air Exposed Pulmonary Epithelia
Carius P, Dubois A, Ajdarirad M, Artzy-Schnirman A, Sznitman J, Schneider-Daum N, Lehr C (2021)
Frontiers in Bioengineering and Biotechnology 9DOI: 10.3389/fbioe.2021.743236
Fucosylated lipid nanocarriers loaded with antibiotics efficiently inhibit mycobacterial propagation in human myeloid cells
Durán V, Grabski E, Hozsa C, Becker J, Yasar H, Monteiro J, Costa B, Koller N, Lueder Y, Wiegmann B, …, Graalmann T, Kalinke U (2021)
Journal of controlled release : official journal of the Controlled Release Society 334: 201-212DOI: 10.1016/j.jconrel.2021.04.012
Formulation and evaluation of transdermal nanogel for delivery of artemether
Nnamani P, Ugwu A, Nnadi O, Kenechukwu F, Ofokansi K, Attama A, Lehr C (2021)
Drug delivery and translational research 11 (4): 1655-1674DOI: 10.1007/s13346-021-00951-4
Development and evaluation of a quality control system based on transdermal electrical resistance for skin barrier function in vitro
Knoth K, Zäh R, Veldung B, Burgio D, Wiegand B, Smola H, Bock U, Lehr C, Hittinger M, Groß H (2021)
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)DOI: 10.1111/srt.12998
Analysis and Optimization of Two Film-Coated Tablet Production Processes by Computer Simulation: A Case Study
Hering S, Schäuble N, Buck T, Loretz B, Rillmann T, Stieneker F, Lehr C (2021)
Processes 9 (1)DOI: 10.3390/pr9010067
Tobramycin Liquid Crystal Nanoparticles Eradicate Cystic Fibrosis-Related Pseudomonas aeruginosa Biofilms
Thorn C, Carvalho-Wodarz C, Horstmann J, Lehr C, Prestidge C, Thomas N (2021)
Small (Weinheim an der Bergstrasse, Germany) 17 (24)DOI: 10.1002/smll.202100531
Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane
Zamprogno P, Wüthrich S, Achenbach S, Thoma G, Stucki J, Hobi N, Schneider-Daum N, Lehr C, Huwer H, Geiser T, Schmid R, Guenat O (2021)
Communications Biology 4 (1)DOI: 10.1038/s42003-021-01695-0
Human Skin Permeation Enhancement Using PLGA Nanoparticles Is Mediated by Local pH Changes
Luengo J, Schneider M, Schneider A, Lehr C, Schaefer U (2021)
Pharmaceutics 13 (10)DOI: 10.3390/pharmaceutics13101608
Drug delivery for fighting infectious diseases: a global perspective
Loretz B, Oh Y, Hudson S, Gu Z, Lehr C (2021)
Drug delivery and translational research 11 (4): 1316-1322DOI: 10.1007/s13346-021-01009-1
Drug delivery to the inflamed intestinal mucosa- targeting technologies and human cell culture models for better therapies of IBD
Olga H, Shetab Boushehri Maryam A, Shalaby Karim S, Brigitta L, Alf L, Claus-Michael L (2021)
Advanced Drug Delivery ReviewsDOI: 10.1016/j.addr.2021.113828
Novel (‒)-carvone derivatives as potential anticonvulsant and analgesic agents
Nesterkina M, Barbalat D, Konovalova I, Shishkina S, Atakay M, Salih B, Kravchenko I (2021)
Natural product research 35 (23): 4978-4987DOI: 10.1080/14786419.2020.1756804
Simultaneous Complexation and Microextraction Using Verbenone Hydrazone as the Ligand with Slotted Quartz Tube-Flame Atomic Absorption Spectrometry (FAAS) for the Sensitive Determination of Copper
Özzeybek G, Borahan T, Nesterkina M, Kravchenko I, Bakirdere S (2021)
Analytical letters 54 (14): 2376-2386DOI: 10.1080/00032719.2020.1866594
Quantitative structure–activity relationship study on prolonged anticonvulsant activity of terpene derivatives in pentylenetetrazole test
Nesterkina M, Muratov V, Ognichenko L, Kravchenko I, Kuz’min V (2021)
Open Chemistry 19 (1): 1184-1192DOI: 10.1515/chem-2021-0108
Rheological Properties of Hyaluronic Acid Diluted Solutions as Components of Cosmetics
Svetlana Saitarly, Yuriy Pushkarev, Mariia Nesterkina, Serhat Öztürk, Iryna Kravchenko (2021)
Biointerface Res Appl Chem 12 (2): 1907-1915DOI: 10.33263/BRIAC122.19071915
Terpenoid Hydrazones as Biomembrane Penetration Enhancers: FT-IR Spectroscopy and Fluorescence Probe Studies
Nesterkina M, Smola S, Rusakova N, Kravchenko I (2021)
Molecules (Basel, Switzerland) 27 (1)DOI: 10.3390/molecules27010206
Targeting the IspD Enzyme in the MEP Pathway: Identification of a Novel Fragment Class
Diamanti E, Hamed M, Lacour A, Bravo P, Illarionov B, Fischer M, Rottmann M, Witschel M, Hirsch A (2021)
ChemMedChemDOI: 10.1002/cmdc.202100679
Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors
Kaya C, Walter I, Yahiaoui S, Sikandar A, Alhayek A, Konstantinovic J, Kany A, Haupenthal J, Köhnke J, Hartmann R, Hirsch A (2021)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202112295
Targeting the energy-coupling factor (ECF) transporters: identification of new tool compounds
Diamanti E, Setyawati I, Bousis S, Souza P, mojas l, Swier l, Haupenthal J, Gibson P, Volz C, stanek w, …, slotboom d, Hirsch A (2021)
ChemRxivDOI: 10.26434/chemrxiv-2021-xq08b-v2
Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier
Abdallah M, Hamed M, Frakolaki E, Katsamakas S, Vassilaki N, Bartenschlager R, Zoidis G, Hirsch A, Abdel-Halim M, Abadi A (2021)
European journal of medicinal chemistryDOI: 10.1016/j.ejmech.2021.114034
Unveiling Adatoms in On-Surface Reactions: Combining Scanning Probe Microscopy with van't Hoff Plots
Moreno-López J, Pérez Paz A, Gottardi S, Solianyk L, Li J, Monjas L, Hirsch A, Mowbray D, Stöhr M (2021)
The journal of physical chemistry. C, Nanomaterials and interfaces 125 (18): 9847-9854DOI: 10.1021/acs.jpcc.1c03134
An efficient way to screen inhibitors of energy-coupling factor (ECF) transporters in bacteria uptake assay
Bousis S, Winkler S, Haupenthal J, Fulco F, Diamanti E, Hirsch A (2021)
ChemRxivDOI: 10.26434/chemrxiv-2021-b50gj
Genome-Guided Discovery of the First Myxobacterial Biarylitide Myxarylin Reveals Distinct C-N Biaryl Crosslinking in RiPP Biosynthesis
Hug J, Frank N, Walt C, Šenica P, Panter F, Müller R (2021)
Molecules 26 (24)DOI: 10.3390/molecules26247483
Structure of Escherichia coli cytochrome bd-II type oxidase with bound aurachin D
Grauel A, Kägi J, Rasmussen T, Makarchuk I, Oppermann S, Moumbock A, Wohlwend D, Müller R, Melin F, Günther S, …, Böttcher B, Friedrich T (2021)
Nat Commun 12 (1)DOI: 10.1038/s41467-021-26835-2
1st Spring Virtual Meeting on Medicinal Chemistry
Sousa M, Marques M, Faustino M (2021)
Chemistry Proceedings 4 (1)DOI: 10.3390/chemproc2021004001
Structure and Biosynthesis of Myxofacyclines: Unique Myxobacterial Polyketides Featuring Varing and Rare Heterocycles *
Popoff A, Hug J, Walesch S, Garcia R, Keller L, Müller R (2021)
Chem. Eur. J. 27 (67): 16654-16661DOI: 10.1002/chem.202103095
The natural product vioprolide A exerts anti-inflammatory actions through inhibition of its cellular target NOP14 and downregulation of importin-dependent NF-ĸB p65 nuclear translocation
Burgers L, Luong B, Li Y, Fabritius M, Michalakis S, Reichel C, Müller R, Fürst R (2021)
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 144DOI: 10.1016/j.biopha.2021.112255
Distinct Patterns of Blood Cytokines Beyond a Cytokine Storm Predict Mortality in COVID-19
Herr C, Mang S, Mozafari B, Guenther K, Speer T, Seibert M, Srikakulam S, Beisswenger C, Ritzmann F, Keller A, …, Lepper P, Bals R (2021)
Journal of inflammation research 14: 4651-4667DOI: 10.2147/JIR.S320685
Design, synthesis, and biological evaluation of novel benzimidazole derivatives as sphingosine kinase 1 inhibitor
Khairat S, Omar M, Ragab F, Roy S, Turab Naqvi A, Abdelsamie A, Hirsch A, Galal S, Hassan M, El Diwani H (2021)
Archiv der Pharmazie 354 (9)DOI: 10.1002/ardp.202100080
Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Treatment of Dengue Infections Applied to the Broad Spectrum Antiviral Soraphen A
Rox K, Heyner M, Krull J, Harmrolfs K, Rinne V, Hokkanen J, Perez Vilaro G, Díez J, Müller R, Kröger A, Sugiyama Y, Brönstrup M (2021)
ACS Pharmacol. Transl. Sci.DOI: 10.1021/acsptsci.1c00078
Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization
Della Volpe S, Linciano P, Listro R, Tumminelli E, Amadio M, Bonomo I, Elgaher W, Adam S, Hirsch A, Boeckler F, …, Rossi D, Collina S (2021)
Bioorganic chemistry 116DOI: 10.1016/j.bioorg.2021.105305
Expanding the Myxochelin Natural Product Family by Nicotinic Acid Containing Congeners
Frank N, Széles M, Akone S, Rasheed S, Hüttel S, Frewert S, Hamed M, Herrmann J, Schuler S, Hirsch A, Müller R (2021)
Molecules 26 (16)DOI: 10.3390/molecules26164929
N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa
Yahiaoui S, Voos K, Haupenthal J, Wichelhaus T, Frank D, Weizel L, Rotter M, Brunst S, Kramer J, Proschak E, Ducho C, Hirsch A (2021)
RSC Med. Chem.DOI: 10.1039/D1MD00187F
Crystalline sponge affinity screening: A fast tool for soaking condition optimization without the need of X-ray diffraction analysis
Rosenberger L, Essen C, Khutia A, Kühn C, Georgi K, Hirsch A, Hartmann R, Badolo L (2021)
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 164DOI: 10.1016/j.ejps.2021.105884
Non-Carbohydrate Glycomimetics as Inhibitors of Calcium(II)-Binding Lectins
Kuhaudomlarp S, Siebs E, Shanina E, Topin J, Joachim I, da Silva Figueiredo Celestino Gomes P, Varrot A, Rognan D, Rademacher C, Imberty A, Titz A (2021)
Angew. Chem. Int. Ed. 60 (15): 8104-8114DOI: 10.1002/anie.202013217
The exo-β-N-acetylmuramidase NamZ from Bacillus subtilis is the founding member of a family of exo-lytic peptidoglycan hexosaminidases
Müller M, Calvert M, Hottmann I, Kluj R, Teufel T, Balbuchta K, Engelbrecht A, Selim K, Xu Q, Borisova M, Titz A, Mayer C (2021)
The Journal of biological chemistry 296DOI: 10.1016/j.jbc.2021.100519
Sesbanimide R, a Novel Cytotoxic Polyketide Produced by Magnetotactic Bacteria
Awal R, Haack P, Bader C, Riese C, Schüler D, Müller R (2021)
mBio 12 (3)DOI: 10.1128/mBio.00591-21
A Custom-Made Device for Reproducibly Depositing Pre-metered Doses of Nebulized Drugs on Pulmonary Cells in vitro
Horstmann J, Thorn C, Carius P, Graef F, Murgia X, Souza Carvalho-Wodarz C, Lehr C (2021)
Frontiers in Bioengineering and Biotechnology 9DOI: 10.3389/fbioe.2021.643491
Decoding (patho-)physiology of the lung by advanced in vitro models for developing novel anti-infectives therapies
Montefusco-Pereira C, Carvalho-Wodarz C, Seeger J, Kloft C, Michelet R, Lehr C (2021)
Drug Discovery Today 26 (1): 148-163DOI: 10.1016/j.drudis.2020.10.016
Testing of aerosolized ciprofloxacin nanocarriers on cystic fibrosis airway cells infected with P. aeruginosa biofilms
Juntke J, Murgia X, Günday Türeli N, Türeli A, Thorn C, Schneider M, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2021)
Drug delivery and translational research 11 (4): 1752-1765DOI: 10.1007/s13346-021-01002-8
Microbiota and cancer: In vitro and in vivo models to evaluate nanomedicines
Ladaycia A, Loretz B, Passirani C, Lehr C, Lepeltier E (2021)
Advanced Drug Delivery Reviews 170: 44-70DOI: 10.1016/j.addr.2020.12.015
A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms
Schütz C, Ho D, Hamed M, Abdelsamie A, Röhrig T, Herr C, Kany A, Rox K, Schmelz S, Siebenbürger L, …, Lehr C, Empting M (2021)
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8 (12)DOI: 10.1002/advs.202004369
Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals
Thiyagarajan D, Huck B, Nothdurft B, Koch M, Rudolph D, Rutschmann M, Feldmann C, Hozsa C, Furch M, Besecke K, …, Loretz B, Lehr C (2021)
Drug delivery and translational research 11 (4): 1766-1778DOI: 10.1007/s13346-021-01011-7
Extracellular vesicles as antigen carriers for novel vaccination avenues
Mehanny M, Lehr C, Fuhrmann G (2021)
Advanced Drug Delivery Reviews 173: 164-180DOI: 10.1016/j.addr.2021.03.016
Extracellular vesicles as novel assay tools to study cellular interactions of anti-infective compounds - A perspective
Richter R, Lehr C (2021)
Advanced Drug Delivery Reviews 173: 492-503DOI: 10.1016/j.addr.2021.04.010
Disease Models: Lung Models for Testing Drugs Against Inflammation and Infection
Carius P, Horstmann J, Souza Carvalho-Wodarz C, Lehr C (2021)
Handbook of experimental pharmacology 265: 157-186DOI: 10.1007/164_2020_366
Eap-functionalized liposomes as a bioinspired delivery system for oral delivery of colistin to treat intracellular Salmonella infection
Menina S (2021)
Book
Zebrafish: An Attractive Model to Study Staphylococcus aureus Infection and Its Use as a Drug Discovery Tool
Rasheed S, Fries F, Müller R, Herrmann J (2021)
Pharmaceuticals 14 (6)DOI: 10.3390/ph14060594
“Clicking“ fragment leads to novel dual-binding cholinesterase inhibitors
Moleda Z, Zawadzka A, Czarnocki Z, Monjas L, Hirsch A, Budzianowski A, Maurin J (2021)
Bioorg Med ChemDOI: 10.1016/j.bmc.2021.116269
Structure and biosynthesis of sorangipyranone - a new γ-dihydropyrone from the myxobacterial strain MSr12020
Okoth D, Hug J, Mándi A, Kurtán T, Garcia R, Müller R (2021)
Journal of Industrial Microbiology & Biotechnology 48 (3-4)DOI: 10.1093/jimb/kuab029
Phosphonate as a Stable Zinc‐Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH) (ChemMedChem 8/2021)
Voos K, Schönauer E, Alhayek A, Haupenthal J, Andreas A, Müller R, Hartmann R, Brandstetter H, Hirsch A, Ducho C (2021)
ChemMedChem 16 (8): 1198-1198DOI: 10.1002/cmdc.202100229
Hit-optimization using target-directed dynamic combinatorial chemistry: Development of inhibitors of the anti-infective target 1-deoxy-D-xylulose-5-phosphate synthase
Jumde R, Guadigni M, Gierse R, Alhayek A, Di Zhu, Hamid Z, Johannsen S, Elgaher W, Neusens P, Nehls C, …, Reiling N, Hirsch A (2021)
Chemical ScienceDOI: 10.1039/D1SC00330E
miRMaster 2.0: multi-species non-coding RNA sequencing analyses at scale
Fehlmann T, Kern F, Laham O, Backes C, Solomon J, Hirsch P, Volz C, Müller R, Keller A (2021)
Nucleic Acids ResDOI: 10.1093/nar/gkab268
Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity
Ropponen H, Bader C, Diamanti E, Illarionov B, Rottmann M, Fischer M, Witschel M, Müller R, Hirsch A (2021)
ChemMedChem 16 (13): 2089-2093DOI: 10.1002/cmdc.202100067
Synergizing the potential of bacterial genomics and metabolomics to find novel antibiotics
Panter F, Bader C, Müller R (2021)
Chem. Sci. 12 (17): 5994-6010DOI: 10.1039/d0sc06919a
Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection
Mamareli P, Kruse F, Lu C, Guderian M, Floess S, Rox K, Allan D, Carlyle J, Brönstrup M, Müller R, …, Sparwasser T, Lochner M (2021)
Mucosal Immunol. 14 (1): 164-176DOI: 10.1038/s41385-020-0285-7
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis
Almeida L, Dhillon-LaBrooy A, Castro C, Adossa N, Carriche G, Guderian M, Lippens S, Dennerlein S, Hesse C, Lambrecht B, …, Moita L, Sparwasser T (2021)
Immunity 54 (1): 68-83DOI: 10.1016/j.immuni.2020.11.001
Stimulation of Probiotic Bacteria Induces Release of Membrane Vesicles with Augmented Anti-inflammatory Activity
Müller L, Kuhn T, Koch M, Fuhrmann G (2021)
ACS Appl. Bio Mater.DOI: 10.1021/acsabm.0c01136
Mastering the Gram-Negative Bacterial Barrier - Chemical Approaches to Increase Bacterial Bioavailability of Antibiotics
Ropponen H, Richter R, Hirsch A, Lehr C (2021)
Advanced Drug Delivery ReviewsDOI: 10.1016/j.addr.2021.02.014
Assessment of the rules related to gaining activity against Gram-negative bacteria
Ropponen H, Diamanti E, Siemens A, Illarionov B, Haupenthal J, Fischer M, Rottmann M, Witschel M, Hirsch A (2021)
RSC Med. Chem.DOI: 10.1039/D0MD00409J
Natural products in drug discovery: advances and opportunities
Atanasov A, Zotchev S, Dirsch V, Supuran C (2021)
Nature reviews. Drug discovery 20 (3): 200-216DOI: 10.1038/s41573-020-00114-z
Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design
Axer A, Jumde R, Adam S, Faust A, Schäfers M, Fobker M, Koehnke J, Hirsch A, Gilmour R (2021)
Chem. Sci. 12 (4): 1286-1294DOI: 10.1039/D0SC04297H
Phosphonate as Stable Zinc-binding Group for Inhibitors of Clostridial Collagenase H (ColH) as Pathoblocker Agents
Voos K, Schönauer E, Alhayek A, Haupenthal J, Andreas A, Müller R, Hartmann R, Brandstetter H, Hirsch A, Ducho C (2021)
ChemMedChemDOI: 10.1002/cmdc.202000994
Inhibitors of Pseudomonas aeruginosa virulence factor LasB
Kaya C, Konstantinovic J, Voos K, Walter I, Kany A, Yahiaoui S, Ducho C, Haupenthal J, Hartmann R, Hirsch A (2021)
Patent (EP20192608.6)
Expanding the Scope of Detectable Microbial Natural Products by Complementary Analytical Methods and Cultivation Systems
Bader C, Haack P, Panter F, Krug D, Müller R (2021)
Journal of natural products 84 (2): 268-277DOI: 10.1021/acs.jnatprod.0c00942
Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties
Gierse R, Reddem E, Alhayek A, Baitinger D, Hamid Z, Jakobi H, Laber B, Lange G, Hirsch A, Groves (2021)
Biochemical and Biophysical Research Communications 539DOI: 10.1016/j.bbrc.2020.12.069
Kibdelosporangium persicum sp. nov., a new member of the Actinomycetes from a hot desert in Iran
Safaei N, Nouioui I, Mast Y, Zaburannyi N, Rohde M, Schumann P, Müller R, Wink J (2021)
Int. J. Syst. Evol. Microbiol. 71 (2)DOI: 10.1099/ijsem.0.004625