Publications
Publication Highlights
Have a look at our latest discoveries.
Publication database
2021
Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties
Gierse R, Reddem E, Alhayek A, Baitinger D, Hamid Z, Jakobi H, Laber B, Lange G, Hirsch A, Groves (2021)
Biochemical and Biophysical Research Communications, 539DOI: 10.1016/j.bbrc.2020.12.069
Kibdelosporangium persicum sp. nov., a new member of the Actinomycetes from a hot desert in Iran
Safaei N, Nouioui I, Mast Y, Zaburannyi N, Rohde M, Schumann P, Müller R, Wink J (2021)
Int J Syst Evol MicrobiolDOI: 10.1099/ijsem.0.004625
2020
Supercritical Fluid Extraction Enhances Discovery of Secondary Metabolites from Myxobacteria
Bader C, Neuber M, Panter F, Krug D, Müller R (2020)
Analytical chemistryDOI: 10.1021/acs.analchem.0c02995
An ambruticin-sensing complex modulates Myxococcus xanthus development and mediates myxobacterial interspecies communication
Marcos-Torres F, Volz C, Müller R (2020)
Nat Commun, 11 (1)DOI: 10.1038/s41467-020-19384-7
PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus
Anversa Dimer F, Souza Carvalho-Wodarz C, Goes A, Cirnski K, Herrmann J, Schmitt V, Pätzold L, Abed N, Rossi C, Bischoff M, …, Müller R, Lehr C (2020)
Nanomedicine : nanotechnology, biology, and medicine, 24DOI: 10.1016/j.nano.2019.102125
Potential Dental Biofilm Inhibitors: Dynamic Combinatorial Chemistry Affords Sugar-Based Molecules that Target Bacterial Glucosyltransferase
Hartman A, Jumde V, Elgaher W, Te Poele E, Dijkhuizen L, Hirsch A (2020)
ChemMedChemDOI: 10.1002/cmdc.202000222
SphereCon-a method for precise estimation of residue relative solvent accessible area from limited structural information
Gress A, Kalinina O (2020)
Bioinformatics (Oxford, England), 36 (11): 3372-3378DOI: 10.1093/bioinformatics/btaa159
Probiomimetics-Novel Lactobacillus-Mimicking Microparticles Show Anti-Inflammatory and Barrier-Protecting Effects in Gastrointestinal Models
Kuhn T, Koch M, Fuhrmann G (2020)
Small (Weinheim an der Bergstrasse, Germany)DOI: 10.1002/smll.202003158
Discovery of Antibacterial Agents Inhibiting the Energy-Coupling Factor (ECF) Transporters by Structure-Based Virtual Screening
Diamanti E, Setyawati I, Bousis S, mojas l, Swier l, Haupenthal J, Gibson P, Volz C, stanek w, Jaeger m, …, slotboom d, Hirsch A (2020)
BookDOI: 10.26434/chemrxiv.11728710.v1
Streptococcal Extracellular Membrane Vesicles Are Rapidly Internalized by Immune Cells and Alter Their Cytokine Release
Mehanny M, Koch M, Lehr C, Fuhrmann G (2020)
Frontiers in immunology, 11DOI: 10.3389/fimmu.2020.00080
Dual-function chromogenic screening-based CRISPR/Cas9 genome editing system for actinomycetes
Wang Q, Xie F, Tong Y, Habisch R, Yang B, Zhang L, Müller R, Fu C (2020)
Applied Microbiology and Biotechnology, 104 (1): 225-239DOI: 10.1007/s00253-019-10223-4
Heterologous expression of the atypical tetracycline chelocardin reveals the full set of genes required for its biosynthesis
Lukežic T, Pikl Š, Zaburannyi N, Remškar M, Petkovic H, Müller R (2020)
Microb. Cell Fact., 19 (1)DOI: 10.1186/s12934-020-01495-x
François Diederich – In Memoriam**
Fraser Hof, Anna K. H. Hirsch (2020)
ChemMedChemDOI: 10.1002/cmdc.202000920
Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design
Alexander Axer, Ravindra P. Jumde, Sebastian Adam, Andreas Faust, Michael Schäfers, Manfred Fobker, Jesko Koehnke, Anna K. H. Hirsch, Ryan Gilmour (2020)
Chem. Sci.DOI: 10.1039/D0SC04297H
Frontispiece: Protein‐Templated Hit Identification through an Ugi Four‐Component Reaction
Federica Mancini, M. Yagiz Unver, Walid A. M. Elgaher, Varsha R. Jumde, Alaa Alhayek, Peer Lukat, Jennifer Herrmann, Martin D. Witte, Matthias Köck, Wulf Blankenfeldt, Rolf Müller, Anna K. H. Hirsch (2020)
Chemistry – A European Journal, 26 (64)DOI: 10.1002/chem.202086462
Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections
Schiefer A, Hübner M, Krome A, Lämmer C, Ehrens A, Aden T, Koschel M, Neufeld H, Chaverra-Muñoz L, Jansen R, …, Pfarr K, Hoerauf A (2020)
PLoS Negl. Trop. Dis., 14 (12)DOI: 10.1371/journal.pntd.0008930
Leben und Überleben im Boden: Myxococcus xanthus ist Mikrobe des Jahres 2020
Volz C, Krug D, Müller R (2020)
Biol. Unserer Zeit, 50 (6): 424-432DOI: 10.1002/biuz.202010721
The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase
Lilic M, Chen J, Boyaci H, Braffman N, Hubin E, Herrmann J, Müller R, Mooney R, Landick R, Darst S, Campbell E (2020)
Proc. Natl. Acad. Sci. U.S.A.DOI: 10.1073/pnas.2013706117
Protein-Templated Hit Identification through an Ugi Four-Component Reaction*
Mancini F, Unver M, Elgaher W, Jumde V, Alhayek A, Lukat P, Herrmann J, Witte M, Köck M, Blankenfeldt W, Müller R, Hirsch A (2020)
Chemistry (Weinheim an der Bergstrasse, Germany), 26 (64): 14585-14593DOI: 10.1002/chem.202002250
Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry
Cirnski K, Coetzee J, Herrmann J, Müller R (2020)
J. Vis. Exp. (164)DOI: 10.3791/61703
A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria
Richter R, Kamal M, García-Rivera M, Kaspar J, Junk M, Elgaher W, Srikakulam S, Gress A, Beckmann A, Grißmer A, …, Schneider-Daum N, Lehr C (2020)
Materials Today BioDOI: 10.1016/j.mtbio.2020.100084
Protein-observed 19F NMR of LecA from Pseudomonas aeruginosa
Shanina E, Siebs E, Zhang H, Silva D, Joachim I, Titz A, Rademacher C (2020)
GlycobiologyDOI: 10.1093/glycob/cwaa057
Directing Drugs to Bugs: Antibiotic-Carbohydrate Conjugates Targeting Biofilm-Associated Lectins of Pseudomonas aeruginosa
Meiers J, Zahorska E, Röhrig T, Hauck D, Wagner S, Titz A (2020)
Journal of medicinal chemistry, 63 (20): 11707-11724DOI: 10.1021/acs.jmedchem.0c00856
An extended catalogue of tandem alternative splice sites in human tissue transcriptomes
Mironov A, Denisov S, Gress A, Kalinina O, Pervouchine D (2020)
BookDOI: 10.1101/2020.09.11.292722
The bottromycin epimerase BotH defines a group of atypical α/β-hydrolase-fold enzymes
Sikandar A, Franz L, Adam S, Santos-Aberturas J, Horbal L, Luzhetskyy A, Truman A, Kalinina O, Koehnke J (2020)
Nat Chem Biol, 16 (9): 1013-1018DOI: 10.1038/s41589-020-0569-y
DIGGER: exploring the functional role of alternative splicing in protein interactions
Louadi Z, Yuan K, Gress A, Tsoy O, Kalinina O, Baumbach J, Kacprowski T, List M (2020)
Nucleic Acids ResDOI: 10.1093/nar/gkaa768
Frequent subgraph mining for biologically meaningful structural motifs
Keller S, Miettinen P, Kalinina O (2020)
BookDOI: 10.1101/2020.05.14.095695
Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model
Park Y, Meyer M, Müller R, Herrmann J (2020)
Molecules, 25 (19)DOI: 10.3390/molecules25194474
2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene-Nucleoside
Okoth D, Hug J, Garcia R, Spröer C, Overmann J, Müller R (2020)
Molecules (Basel, Switzerland), 25 (11)DOI: 10.3390/molecules25112676
Biosynthesis of Cittilins, Unusual Ribosomally Synthesized and Post-translationally Modified Peptides from Myxococcus xanthus
Hug J, Dastbaz J, Adam S, Revermann O, Koehnke J, Krug D, Müller R (2020)
ACS chemical biology, 15 (8): 2221-2231DOI: 10.1021/acschembio.0c00430
7-Hydroxycoumarins are Affinity-based Fluorescent Probes for Competitive Binding Studies of Macrophage Migration Inhibitory Factor
Xiao Z, Chen D, Song S, van der Vlag R, van der Wouden P, van Merkerk R, Cool R, Hirsch A, Melgert B, Quax W, Poelarends G, Dekker F (2020)
Journal of medicinal chemistryDOI: 10.1021/acs.jmedchem.0c01160
Advancing human in vitro pulmonary disease models in preclinical research: opportunities for lung-on-chips
Artzy-Schnirman A, Lehr C, Sznitman J (2020)
Expert Opinion on Drug Delivery, 17 (5): 621-625DOI: 10.1080/17425247.2020.1738380
Design and in vitro characterization of multistage silicon-PLGA budesonide particles for inflammatory bowel disease
Leonard F, Srinivasan S, Liu X, Collnot E, Ferrari M, Lehr C, Godin B (2020)
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 151: 61-72DOI: 10.1016/j.ejpb.2020.03.020
Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections
Ho D, Murgia X, Rossi C, Christmann R, Hüfner de Mello Martins A, Koch M, Andreas A, Herrmann J, Müller R, Empting M, …, Couvreur P, Lehr C (2020)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202001407
Safety assessment of excipients (SAFE) for orally inhaled drug products
Metz J, Scharnowske L, Hans F, Schnur S, Knoth K, Zimmer H, Limberger M, Groß H, Lehr C, Hittinger M (2020)
ALTEX, 37 (2): 275-286DOI: 10.14573/altex.1910231
Itaconic Acid Increases the Efficacy of Tobramycin against Pseudomonas aeruginosa Biofilms
Ho D, Rossi C, Loretz B, Murgia X, Lehr C (2020)
Pharmaceutics, 12 (8)DOI: 10.3390/pharmaceutics12080691
P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives
Montefusco-Pereira C, Horstmann J, Ebensen T, Beisswenger C, Bals R, Guzmán C, Schneider-Daum N, Carvalho-Wodarz C, Lehr C (2020)
Journal of visualized experiments : JoVE (160)DOI: 10.3791/61069
Nanoparticle Targeting to Scalp Hair Follicles: New Perspectives for a Topical Therapy for Alopecia Areata
Christmann R, Thomas C, Jager N, Raber A, Loretz B, Schaefer U, Tschernig T, Vogt T, Lehr C (2020)
The Journal of investigative dermatology, 140 (1): 243-246DOI: 10.1016/j.jid.2019.05.028
pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers
Lee S, Kaya C, Jang H, Koch M, Loretz B, Buhler E, Lehr C, Hirsch A (2020)
Mater. Chem. Front., 4 (3): 905-909DOI: 10.1039/C9QM00651F
3D air-liquid interface culture of Cystic Fibrosis bronchial epithelia, macrophages and P. aeruginosa to assess host-pathogen interaction and drug efficacy
Montefusco C, Montefusco-Pereira C (2020)
BookDOI: 10.22028/D291-31815
Inhalationstoxizität von Nanopartikeln // The role of alveolar macrophages in biokinetics and biological effects of inhaled nanoparticles
Koltermann-Jülly J (2020)
BookDOI: 10.22028/D291-31034
Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach
Markella Konstantinidou, Francesca Magari, Fandi Sutanto, Jörg Haupenthal, Varsha R. Jumde, M. Yagiz Ünver, Andreas Heine, Carlos Jamie Camacho, Anna K. H. Hirsch, Gerhard Klebe, Alexander Dömling (2020)
ChemMedChem, 15 (8): 680-684DOI: 10.1002/cmdc.202000024
Optimized Inhibitors of MDM2 via an Attempted Protein‐Templated Reductive Amination
Vlag R, Yagiz Unver M, Felicetti T, Twarda-Clapa A, Kassim F, Ermis C, Neochoritis C, Musielak B, Labuzek B, Dömling A, Holak T, Hirsch A (2020)
ChemMedChem, 15 (4): 370-375DOI: 10.1002/cmdc.201900574
Validating the 1,2-Difluoro Motif As a Hybrid Bioisostere of CF3 and Et Using Matrix Metalloproteinases As Structural Probes
Erdeljac N, Thiehoff C, Jumde R, Daniliuc C, Höppner S, Faust A, Hirsch A, Gilmour R (2020)
Journal of medicinal chemistry, 63 (11): 6225-6237DOI: 10.1021/acs.jmedchem.0c00648
N -Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases
Konstantinovic J, Yahiaoui S, Alhayek A, Haupenthal J, Schönauer E, Andreas A, Kany A, Müller R, Koehnke J, Berger F, …, Brandstetter H, Hirsch A (2020)
J. Med. Chem., 63 (15): 8359-8368DOI: 10.1021/acs.jmedchem.0c00584
Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement
Zielinska A, Savietto A, Sousa Borges A, Martinez D, Berbon M, Roelofsen J, Hartman A, Boer R, van der Klei I, Hirsch A, …, Bramkamp M, Scheffers D (2020)
eLife, 9DOI: 10.7554/eLife.57179
A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d -galactose pentaacetate
Zahorska E, Kuhaudomlarp S, Minervini S, Yousaf S, Lepsik M, Kinsinger T, Hirsch A, Imberty A, Titz A (2020)
Chem. Commun., 56 (62): 8822-8825DOI: 10.1039/d0cc03490h
Enhancing Glycan Stability via Site-Selective Fluorination: Modulating Substrate Orientation by Molecular Design
Axer A, Jumde R, Adam S, Faust A, Schäfers M, Fobker M, Koehnke J, Hirsch A, Gilmour R (2020)
BookDOI: 10.26434/chemrxiv.12656210
Hit-Optimization Using Target-Directed Dynamic Combinatorial Chemistry: Development of Inhibitors of the Anti-Infective Target 1-Deoxy-D-Xylulose-5-Phosphate Synthase
Jumde R, Guardigni M, Gierse R, Alhayek A, Zhu D, Hamed Z, Johannsen S, Elgaher W, Haupenthal J, Hirsch A (2020)
BookDOI: 10.26434/chemrxiv.12681761.v1
Resistance-associated substitutions in patients with chronic hepatitis C virus genotype 4 infection
Dietz J, Kalinina O, Vermehren J, Peiffer K, Matschenz K, Buggisch P, Niederau C, Schattenberg J, Müllhaupt B, Yerly S, …, Welsch C, Sarrazin C (2020)
J. Viral Hepat.DOI: 10.1111/jvh.13322.
Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors
Bastys T, Gapsys V, Walter H, Heger E, Doncheva N, Kaiser R, Groot B, Kalinina O (2020)
Retrovirology, 17 (1)DOI: 10.1186/s12977-020-00520-6
A shift of dynamic equilibrium between the KIT active and inactive states causes drug resistance
Srikakulam S, Bastys T, Kalinina O (2020)
ProteinsDOI: 10.1002/prot.25963
Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy
Testolin G, Cirnski K, Rox K, Prochnow H, Fetz V, Grandclaudon C, Mollner T, Baiyoumy A, Ritter A, Leitner C, …, Müller R, Brönstrup M (2020)
Chemical Science, 11 (5): 1316-1334DOI: 10.1039/C9SC04769G
Restriction-Free Construction of a Phage-Presented Very Short Macrocyclic Peptide Library
Jakob V, Helmsing S, Hust M, Empting M (2020)
Methods in molecular biology (Clifton, N.J.), 2070: 95-113DOI: 10.1007/978-1-4939-9853-1_6
Discovery of Novel Latency-Associated Nuclear Antigen Inhibitors as Antiviral Agents Against Kaposi's Sarcoma-Associated Herpesvirus
Kirsch P, Jakob V, Elgaher W, Walt C, Oberhausen K, Schulz T, Empting M (2020)
ACS chemical biology, 15 (2): 388-395DOI: 10.1021/acschembio.9b00845
Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling
Hollenhorst M, Jurastow I, Nandigama R, Appenzeller S, Li L, Vogel J, Wiederhold S, Althaus M, Empting M, Altmüller J, …, Saliba A, Krasteva-Christ G (2020)
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34 (1): 316-332DOI: 10.1096/fj.201901314RR
BOPC1 Enantiomers Preparation and HuR Interaction Study. From Molecular Modeling to a Curious DEEP-STD NMR Application
Della Volpe S, Listro R, Parafioriti M, Di Giacomo M, Rossi D, Ambrosio F, Costa G, Alcaro S, Ortuso F, Hirsch A, Vasile F, Collina S (2020)
ACS Med. Chem. Lett., 11 (5): 883-888DOI: 10.1021/acsmedchemlett.9b00659
Synthesis and Biological Evaluation of Novel 2-Substituted Analogues of (–)-Pentenomycin I
Zisopoulou S, Bousis S, Haupenthal J, Herrmann J, Müller R, Hirsch A, Komiotis D, Gallos J, Stathakis C (2020)
Synlett, 31 (05): 475-481DOI: 10.1055/s-0039-1690772
Liver-derived extracellular vesicles: A cell by cell overview to isolation and characterization practices
Zivko C, Fuhrmann G, Luciani P (2020)
Biochimica et Biophysica Acta - General SubjectsDOI: 10.1016/j.bbagen.2020.129559
Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility
Montefusco-Pereira C, Formicola B, Goes A, Re F, Marrano C, Mantegazza F, Carvalho-Wodarz C, Fuhrmann G, Caneva E, Nicotra F, Lehr C, Russo L (2020)
European Journal of Pharmaceutics and Biopharmaceutics, 149: 12-20DOI: 10.1016/j.ejpb.2020.01.013
Diffusion and transport of extracellular vesicles
Fuhrmann G (2020)
Nature Nanotechnology, 15 (3): 168-169DOI: 10.1038/s41565-020-0651-3
Expression, Purification, and Functional Characterization of Tectonin 2 from Laccaria bicolor: A Six-Bladed Beta-Propeller Lectin Specific for O-Methylated Glycans
Wohlschlager T, Titz A, Künzler M, Varrot A (2020)
Methods Mol Biol, 2132: 669-682DOI: 10.1007/978-1-0716-0430-4_58
Bacteria as genetically programmable producers of bioactive natural products
Hug J, Krug D, Müller R (2020)
Nat. rev. chem., 4 (4): 172-193DOI: 10.1038/s41570-020-0176-1
Host Development for Heterologous Expression and Biosynthetic Studies of Myxobacterial Natural Products
Hug J, Müller R (2020)
, In pressDOI: 10.1016/B978-0-12-409547-2.14818-8
Myxobakterielle Naturstofffabriken
Krug D, Garcia R, Müller R (2020)
Biospektrum, 26 (1): 32-36DOI: 10.1007/s12268-020-1334-1
In depth natural product discovery - Myxobacterial strains that provided multiple secondary metabolites
Bader C, Panter F, Müller R (2020)
Biotechnol Adv., 39DOI: 10.1016/j.biotechadv.2019.107480