Publications
Publication Highlights
Have a look at our latest discoveries.
Publication database
2024
Decoding the diagnostic and therapeutic potential of microbiota using pan-body pan-disease microbiomics
Schmartz G, Rehner J, Gund M, Keller V, Molano L, Rupf S, Hannig M, Berger T, Flockerzi E, Seitz B, …, Bals R, Keller A (2024)
Nat Commun 15 (1)DOI: 10.1038/s41467-024-52598-7
Discovery of the Pendulisporaceae: An extremotolerant myxobacterial family with distinct sporulation behavior and prolific specialized metabolism
Garcia R, Popoff A, Bader C, Löhr J, Walesch S, Walt C, Boldt J, Bunk B, Haeckl F, Gunesch A, …, Bach T, Müller R (2024)
Chem 10: 1-20DOI: 10.1016/j.chempr.2024.04.019
Identification by Synthesis: Imidacins, Urocanate-Derived Alkaloids from the Myxobacterium Stigmatella aurantiaca
Kostka M, Krug D, Herrmann J, Dickschat J, Meyer J, Müller R, Schulz S (2024)
Org. Lett.DOI: 10.1021/acs.orglett.4c02036
SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination
Iram T, Garcia M, Amand J, Kaur A, Atkins M, Iyer M, Lam M, Ambiel N, Jorgens D, Keller A, …, Kern F, Zuchero J (2024)
Proc. Natl. Acad. Sci. U.S.A. 121 (12)DOI: 10.1073/pnas.2307250121
The Peptide Antibiotic Corramycin Adopts a β-Hairpin-like Structure and Is Inactivated by the Kinase ComG
Adam S, Fries F, Tesmar A, Rasheed S, Deckarm S, Sousa C, Reberšek R, Risch T, Mancini S, Herrmann J, …, Kalinina O, Müller R (2024)
J. Am. Chem. Soc.DOI: 10.1021/jacs.3c13208
ZEBRA: a hierarchically integrated gene expression atlas of the murine and human brain at single-cell resolution
Flotho M, Amand J, Hirsch P, Grandke F, Wyss-Coray T, Keller A, Kern F (2024)
Nucleic Acids Res 52 (D1): 1089-DOI: 10.1093/nar/gkad990
Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins
Fu C, Liu Y, Walt C, Rasheed S, Bader C, Lukat P, Neuber M, Haeckl F, Blankenfeldt W, Kalinina O, Müller R (2024)
Nat Commun 15 (1)DOI: 10.1038/s41467-024-44953-5
A Novel 3D Printed Model of Infected Human Hair Follicles to Demonstrate Targeted Delivery of Nanoantibiotics
Aliyazdi S, Frisch S, Neu T, Veldung B, Karande P, Schaefer U, Loretz B, Vogt T, Lehr C (2024)
ACS biomaterials science & engineering 10 (8): 4947-4957DOI: 10.1021/acsbiomaterials.4c00570
Statistical analysis of feature-based molecular networking results from non-targeted metabolomics data
Pakkir Shah A, Walter A, Ottosson F, Russo F, Navarro-Diaz M, Boldt J, Kalinski J, Kontou E, Elofson J, Polyzois A, …, Ernst M, Petras D (2024)
Nature protocolsDOI: 10.1038/s41596-024-01046-3
Optimization of the Central α-Amino Acid in Cystobactamids to the Broad-Spectrum, Resistance-Breaking Antibiotic CN-CC-861
Kohnhäuser D, Seedorf T, Cirnski K, Heimann D, Coetzee J, Sordello S, Richter J, Stappert M, Sabuco J, Corbett D, …, Kirschning A, Brönstrup M (2024)
J. Med. Chem.DOI: 10.1021/acs.jmedchem.4c00927&ref=pdf
Isofunctional but Structurally Different Methyltransferases for Dithiolopyrrolone Diversification
Su L, Huber E, Westphalen M, Gellner J, Bode E, Köbel T, Grün P, Alanjary M, Glatter T, Cirnski K, …, Groll M, Bode H (2024)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202410799
The HIPS 2024 symposium: highlighting advances in pharmaceutical sciences in infection research
Mayoka G, Krug D, Loretz B, Bozhüyük K, Empting M, Hirsch A, Müller R (2024)
Trends in MicrobiologyDOI: 10.1016/j.tim.2024.07.007
Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE
Braun-Cornejo M, Ornago C, Sonawane V, Haupenthal J, Kany A, Diamanti E, Jézéquel G, Reiling N, Blankenfeldt W, Maas P, Hirsch A (2024)
ACS omegaDOI: 10.1021/acsomega.4c05537
Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes
Chan A, Ho T, Fathoni I, Hamid R, Hirsch A, Saliba K, Leeper F (2024)
RSC Med. Chem. 15 (5): 1773-1781DOI: 10.1039/D4MD00083H
Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes
Chen X, Zhao H, Wang C, Hamed M, Shang Q, Yang Y, Diao X, Sun X, Hu W, Jiang X, …, Wu D, Zhuang J (2024)
Int. J. Antimicrob. Agents 63 (5)DOI: 10.1016/j.ijantimicag.2024.107160
Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application
Hofer W, Deschner F, Jézéquel G, Pessanha de Carvalho L, Abdel-Wadood N, Pätzold L, Bernecker S, Morgenstern B, Kany A, Große M, …, Herrmann J, Müller R (2024)
Angewandte Chemie (International ed. in English) 63 (19)DOI: 10.1002/anie.202319765
Arg-biodynamers as antibiotic potentiators through interacting with Gram-negative outer membrane lipopolysaccharides
Kamal M, Bassil J, Loretz B, Hirsch A, Lee S, Lehr C (2024)
Eur J Pharm Biopharm 200DOI: 10.1016/j.ejpb.2024.114336
AI is a viable alternative to high throughput screening: a 318-target study
Wallach I, Hirsch, Anna K. H. et al. (2024)
Sci Rep 14 (1)DOI: 10.1038/s41598-024-54655-z
Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain
Gawriljuk V, Godoy A, Oerlemans R, Welker L, Hirsch A, Groves M (2024)
Nat. Commun. 15 (1)DOI: 10.1038/s41467-024-50671-9
Dual inhibitors of Pseudomonas aeruginosa virulence factors LecA and LasB
Metelkina O, Konstantinovic J, Klein A, Shafiei R, Fares M, Alhayek A, Yahiaoui S, Elgaher W, Haupenthal J, Titz* A, Hirsch* A (2024)
Chem. Sci. 15DOI: 10.1039/D4SC02703E
Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity
Abdelsamie A, Hamed M, Schütz C, Röhrig T, Kany A, Schmelz S, Blankenfeldt W, Hirsch A, Hartmann R, Empting M (2024)
Eur. J. Med. Chem. 276DOI: 10.1016/j.ejmech.2024.116685
Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms
Osbelt L, Almási É, Wende M, Kienesberger S, Voltz A, Lesker T, Muthukumarasamy U, Knischewski N, Nordmann E, Bielecka A, …, Zechner E, Strowig T (2024)
Nat. Microbiol. 9 (7): 1792-1811DOI: 10.1038/s41564-024-01710-0
Investigation of the Odilorhabdin Biosynthetic Gene Cluster Using NRPS Engineering
Präve L, Seyfert C, Bozhüyük K, Racine E, Müller R, Bode H (2024)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202406389
The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages
Mashayekhi V, Schomisch A, Rasheed S, Aparicio-Puerta E, Risch T, Yildiz D, Koch M, Both S, Ludwig N, Legroux T, …, Hoppstädter J, Kiemer A (2024)
Cell communication and signaling : CCS 22 (1)DOI: 10.1186/s12964-024-01701-y
Mibianto: ultra-efficient online microbiome analysis through k-mer based metagenomics
Hirsch P, Molano L, Engel A, Zentgraf J, Rahmann S, Hannig M, Müller R, Kern F, Keller A, Schmartz G (2024)
Nucleic Acids ResDOI: 10.1093/nar/gkae364
Thermotropic liquid crystals in drug delivery: A versatile carrier for controlled release
Nesterkina M, Kravchenko* I, Hirsch A, Lehr C (2024)
Eur. J. Pharm. Biopharm. 200DOI: 10.1016/j.ejpb.2024.114343
Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy-coupling factor transporters (ECFTs)
Haupenthal J, Rafehi M, Kany A, Lespine A, Stefan K, Hirsch* A, Stefan* S (2024)
Arch. Pharm.DOI: 10.1002/ardp.202400267
Molecular networking and computational NMR analyses uncover six polyketide-terpene hybrids from termite-associated Xylaria isolates
Lee S, Dayras M, Fricke J, Guo H, Balluff S, Schalk F, Yu J, Jeong S, Morgenstern B, Slippers B, Beemelmanns C, Kim K (2024)
Commun Chem 7 (1)DOI: 10.1038/s42004-024-01210-6
Genetic regulation of L-tryptophan metabolism in Psilocybe mexicana supports psilocybin biosynthesis
Seibold P, Dörner S, Fricke J, Schäfer T, Beemelmanns C, Hoffmeister D (2024)
Fungal biology and biotechnology 11 (1)DOI: 10.1186/s40694-024-00173-6
Metabolism and cytotoxicity studies of the two hallucinogens 1cP-LSD and 4-AcO-DET in human liver and zebrafish larvae models using LC-HRMS/MS and a high-content screening assay
Gampfer T, Schütz V, Schippers P, Rasheed S, Baumann J, Wagmann L, Pulver B, Westphal F, Flockerzi V, Müller R, Meyer M (2024)
Journal of pharmaceutical and biomedical analysis 245DOI: 10.1016/j.jpba.2024.116187
Point mutations in the ygiV promoter region lead to cystobactamid resistance and reduced virulence in E. coli
Müller R, Risch T, Kolling D, Mostert D, Seedorf T, Heimann D, Kohnhäuser D, Deschner F, Fries F, Solga D, …, Herrmann J, Sieber S (2024)
BookDOI: 10.21203/rs.3.rs-3751821/v1
Time series of chicken stool metagenomics and egg metabolomics in changing production systems: preliminary insights from a proof-of-concept
Rosch M, Rehner J, Schmartz G, Manier S, Becker U, Müller R, Meyer M, Keller A, Becker S, Keller V (2024)
One health outlook 6 (1)DOI: 10.1186/s42522-024-00100-0
Targeting Intracellular Bacteria with Dual Drug-loaded Lactoferrin Nanoparticles
Andima M, Boese A, Paul P, Koch M, Loretz B, Lehr C (2024)
ACS Infect. Dis.DOI: 10.1021/acsinfecdis.4c00045
Structure Revision of a Widespread Marine Sulfonolipid Class Based on Isolation and Total Synthesis
Roman D, Meisinger P, Guillonneau R, Peng C, Peltner L, Jordan P, Haensch V, Götze S, Werz O, Hertweck C, Chen Y, Beemelmanns C (2024)
Angew. Chem. Int. Ed.: 1433-7851DOI: 10.1002/anie.202401195
Antibiotic resistance and tolerance: What can drug delivery do against this global threat?
Aparicio-Blanco J, Vishwakarma N, Lehr C, Prestidge C, Thomas N, Roberts R, Thorn C, Melero A (2024)
Drug delivery and translational researchDOI: 10.1007/s13346-023-01513-6
Minimum Information for Conducting and Reporting In Vitro Intracellular Infection Assays
Subramaniam S, Joyce P, Ogunniyi A, Dube A, Sampson S, Lehr C, Prestidge C (2024)
ACS Infect. Dis. 10 (2): 337-349DOI: 10.1021/acsinfecdis.3c00613
Drug solubility in biorelevant media in the context of an inhalation-based biopharmaceutics classification system (iBCS)
Floroiu A, Loretz B, Krämer J, Lehr C (2024)
Eur J Pharm Biopharm 197DOI: 10.1016/j.ejpb.2024.114206
Biorelevant subcutaneous in vitro test predicts the release of human and fast acting insulin formulations
Schöner T, Vogel V, Venczel M, Knoth K, Kamm W, Paehler T, Louit G, Terán I, Mundinger P, Marker A, …, Hittinger M, Lehr C (2024)
Int. J. Pharm. 655DOI: 10.1016/j.ijpharm.2024.123995
Isolation of Fidaxomicin and Shunt Metabolites from Actinoplanes deccanensis
Jung E, Hunter M, Dorst A, Major A, Teofilovic T, Müller R, Gademann K (2024)
HCADOI: 10.1002/hlca.202400013
Inhibitory effect of sorangicin A against mutant DNA-dependent RNA polymerase in the obligate intracellular bacterium Chlamydia trachomatis
Li Q, Jansen H, Hansen G, Nurjadi D, Herrmann J, Stadler M, Brönstrup M, Müller R, He C, Graspeuntner S, Rupp J, Shima K (2024)
Int. J. Antimicrob. AgentsDOI: 10.1016/j.ijantimicag.2024.107132
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity
Al-Saad O, Gabr M, Darwish S, Rullo M, Pisani L, Miniero D, Liuzzi G, Kany A, Hirsch A, Abadi A, …, Catto M, Abdel-Halim M (2024)
European journal of medicinal chemistryDOI: 10.1016/j.ejmech.2024.116266
Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence
Brand M, Ritzmann F, Kattler K, Milasius D, Yao Y, Herr C, Kirsch S, Müller R, Yildiz D, Bals R, Beisswenger C (2024)
Respir. Res. 25 (1)DOI: 10.1186/s12931-023-02636-7
A type III polyketide synthase cluster in the phylum Planctomycetota is involved in alkylresorcinol biosynthesis
Milke L, Kabuu M, Zschoche R, Gätgens J, Krumbach K, Carlstedt K, Wurzbacher C, Balluff S, Beemelmanns C, Jogler C, Marienhagen J, Kallscheuer N (2024)
Appl Microbiol Biotechnol 108 (1)DOI: 10.1007/s00253-024-13065-x
Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor
Sake S, Zhang X, Rajak M, Urbanek-Quaing M, Carpentier A, Gunesch A, Grethe C, Matthaei A, Rückert J, Galloux M, …, Haid* S, Pietschmann* T (2024)
Nat. Commun. 15 (1)DOI: 10.1038/s41467-024-45241-y
High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum
Johannsen S, Gierse R, Krüger A, Edwards R, Nanna V, Fontana A, Di Zhu, Masini T, Carvalho L, Poizat M, …, Wrenger C, Hirsch* A (2024)
ACS Infect. Dis.DOI: 10.1021/acsinfecdis.3c00670
Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT
Exapicheidou I, Shams A, Ibrahim H, Tsarenko A, Backenköhler M, Hamed M, Diamanti E, Volkamer A, slotboom d, Hirsch A (2024)
Chem. Commun. 60 (7): 870-873DOI: 10.1039/D3CC04738E
Nitroxoline resistance is associated with significant fitness loss and diminishes in vivo virulence of Escherichia coli
Deschner F, Risch T, Baier C, Schlüter D, Herrmann J, Müller R (2024)
Microbiology Spectrum 12 (1)DOI: 10.1128/spectrum.03079-23
Is Simultaneous Binding to DNA and Gyrase Important for the Antibacterial Activity of Cystobactamids?
Solga D, Wieske L, Wilcox S, Zeilinger C, Jansen-Olliges L, Cirnski K, Herrmann J, Müller R, Erdelyi M, Kirschning A (2024)
Chem. Eur. J.DOI: 10.1002/chem.202303796
New myxobacteria of the Myxococcaceae clade produce angiolams with antiparasitic activities
Walesch S, Garcia R, Mahmoud A, Panter F, Bollenbach S, Mäser P, Kaiser M, Krug D, Müller R (2024)
Microbiology SpectrumDOI: 10.1128/spectrum.03689-23
Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents
Khalifa H, Rasheed S, Haupenthal J, Herrmann J, Mandour Y, Abadi A, Engel M, Müller R, Hirsch A, Abdel-Halim* M, Hamed* M (2024)
Archiv der PharmazieDOI: 10.1002/ardp.202300656
Mining the microbiota for antibiotics
Beemelmanns C, Keller A, Müller R (2024)
Nat. Microbiol. 9 (1): 13-14DOI: 10.1038/s41564-023-01568-8
2023
Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections
Konstantinovic J, Kany A, Alhayek A, Abdelsamie A, Sikandar A, Voos K, Yao Y, Andreas A, Shafiei R, Loretz B, …, Haupenthal J, Hirsch A (2023)
ACS Cent. Sci. 9 (12): 2205-2215DOI: 10.1021/acscentsci.3c01102
Heterologous expression of the cryptic mdk gene cluster and structural revision of maduralactomycin A
Schwitalla J, Le N, Um S, Schalk F, Brönstrup M, Baunach M, Beemelmanns C (2023)
RSC Adv 13 (48): 34136-34144DOI: 10.1039/D3RA05931F
Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery
Afanasenko A, Wu X, Santi A, Elgaher W, Kany A, Shafiei R, Schulze M, Schulz T, Haupenthal J, Hirsch A, Barta K (2023)
Angew. Chem. Int. Ed.DOI: 10.1002/anie.202308131
Identification of HuR–RNA Interfering Compounds by Dynamic Combinatorial Chemistry and Fluorescence Polarization
Della Volpe S, Listro R, Ambrosio F, Garbagnoli M, Linciano P, Rossi D, Costa G, Alcaro S, Vasile F, Hirsch A, Collina S (2023)
ACS Med. Chem. Lett.DOI: 10.1021/acsmedchemlett.3c00303
Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors
Ropponen H, Diamanti E, Johannsen S, Illarionov B, Hamid R, Jaki M, Sass P, Fischer M, Haupenthal J, Hirsch A (2023)
ChemMedChemDOI: 10.1002/cmdc.202300346
Atlas of the aging mouse brain reveals white matter as vulnerable foci
Hahn O, Foltz A, Atkins M, Kedir B, Moran-Losada P, Guldner I, Munson C, Kern F, Pálovics R, Lu N, …, Keller A, Wyss-Coray T (2023)
CellDOI: 10.1016/j.cell.2023.07.027
Revision of the Absolute Configurations of Chelocardin and Amidochelocardin
Sikandar A, Popoff A, Jumde R, Mándi A, Kaur A, Elgaher W, Rosenberger L, Hüttel S, Jansen R, Hunter M, …, Kurtán T, Müller R (2023)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202306437
Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis
Adam S, Zheng D, Klein A, Volz C, Mullen W, Shirran S, Smith B, Kalinina O, Müller R, Koehnke J (2023)
Nature chemistry 15 (4): 560-568DOI: 10.1038/s41557-023-01153-w
Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues
Wagner V, Kern F, Hahn O, Schaum N, Ludwig N, Fehlmann T, Engel A, Henn D, Rishik S, Isakova A, …, Wyss-Coray T, Keller A (2023)
Nat BiotechnolDOI: 10.1038/s41587-023-01751-6
Synthesis of Aryl‐ and Alkyl‐Containing 3‐Methylene‐5‐hydroxy Esters via a Barbier Allylation Reaction
Bartholomäus A, Roman D, Al-Jammal W, Vilotijevic I, Beemelmanns C (2023)
Eur. J. Org. Chem.DOI: 10.1002/ejoc.202300177
The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition
Koller T, Scheid U, Kösel T, Herrmann J, Krug D, Boshoff H, Beckert B, Evans J, Schlemmer J, Sloan B, …, Wilson D, Müller R (2023)
J. Am. Chem. Soc. 145 (2): 851-863DOI: 10.1021/jacs.2c08816
A Monoclonal Human Alveolar Epithelial Cell Line ("Arlo") with Pronounced Barrier Function for Studying Drug Permeability and Viral Infections
Carius P, Jungmann A, Bechtel M, Grißmer A, Boese A, Gasparoni G, Salhab A, Seipelt R, Urbschat K, Richter C, …, Schneider-Daum N, Lehr C (2023)
Adv. Sci. 10 (8)DOI: 10.1002/advs.202207301
Simulated Tempering-Enhanced Umbrella Sampling Improves Convergence of Free Energy Calculations of Drug Membrane Permeation
Sousa C, Becker R, Lehr C, Kalinina O, Hub J (2023)
Journal of chemical theory and computation 19 (6): 1898-1907DOI: 10.1021/acs.jctc.2c01162
Preparation of Co-Amorphous Levofloxacin Systems for Pulmonary Application
Gabelmann A, Lehr C, Grohganz H (2023)
Pharmaceutics 15 (6)DOI: 10.3390/pharmaceutics15061574
Overview of Inhaled Nanopharmaceuticals
Barthold S, Kunschke N, Murgia X, Loretz B, Carvalho-Wodarz C, Lehr C (2023)
Journal of aerosol medicine and pulmonary drug delivery 36 (3): 144-151DOI: 10.1089/jamp.2023.29089.sb
Cell-Derived Vesicles for Antibiotic Delivery-Understanding the Challenges of a Biogenic Carrier System
Heinrich E, Hartwig O, Walt C, Kardani A, Koch M, Jahromi L, Hoppstädter J, Kiemer A, Loretz B, Lehr C, Fuhrmann G (2023)
Small (Weinheim an der Bergstrasse, Germany) 19 (25)DOI: 10.1002/smll.202207479
Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and stability studies
Arrua E, Hartwig O, Loretz B, Murgia X, Ho D, Bastiat G, Lehr C, Salomon C (2023)
Int. J. Pharm. 642DOI: 10.1016/j.ijpharm.2023.123120
Establishment of an In Bacterio Assay for the Assessment of Carbon Storage Regulator A (CsrA) Inhibitors
Wu Y, Zoller B, Kamal M, Hotop S, Lehr C, Brönstrup M, Dersch P, Empting M (2023)
Chembiochem : a European journal of chemical biology 24 (16)DOI: 10.1002/cbic.202300369
Anti-Inflammatory and Antinociceptive Activity of Herbal Lipospheres of Pentaclethra macrophylla (Fabaceae) Stem Bark Extract
Nnamani P, Diovu E, Peter I, Onwuka A, Ogbuanwu C, Abonyi O, Loretz B, Lehr C (2023)
Processes 11 (9)DOI: 10.3390/pr11092557
Functional Materials to Overcome Bacterial Barriers and Models to Advance Their Development
Bali A, Kamal M, Mulla G, Loretz B, Lehr C (2023)
Advanced Functional Materials 33 (45)DOI: 10.1002/adfm.202304370
3D bioprinting ofE. coliMG1655 biofilms on human lung epithelial cells for building complexin vitroinfection models
Aliyazdi S, Frisch S, Hidalgo A, Frank N, Krug D, Müller R, Schaefer U, Vogt T, Loretz B, Lehr C (2023)
Biofabrication 15 (3)DOI: 10.1088/1758-5090/acd95e
Discovery and Characterization of a Myxobacterial Lanthipeptide with Unique Biosynthetic Features and Anti-inflammatory Activity
Wang X, Chen X, Wang Z, Zhuang M, Zhong L, Fu C, Garcia R, Müller R, Zhang Y, Yan J, Wu D, Huo L (2023)
J. Am. Chem. Soc. 145 (30): 16924-16937DOI: 10.1021/jacs.3c06014
The resuscitation-promoting factor (Rpf) from Micrococcus luteus and its putative reaction product 1,6-anhydro-MurNAc increase culturability of environmental bacteria
Guzman J, Raval D, Hauck D, Titz A, Poehlein A, Degenkolb T, Daniel R, Vilcinskas A (2023)
Access microbiology 5 (9)DOI: 10.1099/acmi.0.000647.v4
Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(III) glycoconjugate systems
Wojtczak K, Zahorska E, Murphy I, Koppel F, Cooke G, Titz A, Byrne J (2023)
Chem. Commun. (Cambridge, U. K.) 59 (54): 8384-8387DOI: 10.1039/D3CC02300A
Pseudomonas aeruginosa LecB suppresses immune responses by inhibiting transendothelial migration
Sponsel J, Guo Y, Hamzam L, Lavanant A, Pérez-Riverón A, Partiot E, Muller Q, Rottura J, Gaudin R, Hauck D, …, Römer W, Mueller C (2023)
EMBO reports 24 (4)DOI: 10.15252/embr.202255971
Tackling the outer membrane: facilitating compound entry into Gram-negative bacterial pathogens
Saxena D, Maitra R, Bormon R, Czekanska M, Meiers J, Titz A, Verma S, Chopra S (2023)
npj Antimicrob Resist 1 (1)DOI: 10.1038/s44259-023-00016-1
Glycomimetics for the inhibition and modulation of lectins
Leusmann S, Ménová P, Shanin E, Titz A, Rademacher C (2023)
Chem. Soc. Rev. 52 (11): 3663-3740DOI: 10.1039/d2cs00954d
Molecular replacement for small-molecule crystal structure determination from X-ray and electron diffraction data with reduced resolution
Gorelik T, Lukat P, Kleeberg C, Blankenfeldt W, Mueller R (2023)
Acta crystallographica. Section A, Foundations and advances 79 (Pt 6): 504-514DOI: 10.1107/S2053273323008458
ABC-HuMi: the Atlas of Biosynthetic Gene Clusters in the Human Microbiome
Hirsch P, Tagirdzhanov A, Kushnareva A, Olkhovskii I, Graf S, Schmartz G, Hegemann J, Bozhüyük K, Rolf M, Keller A, Gurevich A (2023)
BookDOI: 10.1101/2023.09.18.558305
Darobactine: eine neue Antibiotikaklasse in Entwicklung
Seyfert C, Porten C, Müller R (2023)
Biospektrum 29 (5): 539-541DOI: 10.1007/s12268-023-1988-6
Resolution of eleven reported and five novel Podaxis species based on ITS phylogeny, phylogenomics, morphology, ecology, and geographic distribution
Li G, Leal-Dutra C, Cuesta-Maté A, Conlon B, Peereboom N, Beemelmanns C, Aanen D, Rosendahl S, Debeer Z, Poulsen M (2023)
Persoonia (Molecular Phylogeny and Evolution of Fungi) 51: 257-279DOI: 10.3767/persoonia.2023.51.07
HypoRiPPAtlas as an Atlas of hypothetical natural products for mass spectrometry database search
Lee Y, Guler M, Chigumba D, Wang S, Mittal N, Miller C, Krummenacher B, Liu H, Cao L, Kannan A, …, Kersten R, Mohimani H (2023)
Nat Commun 14 (1)DOI: 10.1038/s41467-023-39905-4
ABC-HuMi: the Atlas of Biosynthetic Gene Clusters in the Human Microbiome
Hirsch P, Tagirdzhanov A, Kushnareva A, Olkhovskii I, Graf S, Schmartz G, Hegemann J, Bozhüyük K, Müller R, Keller A, Gurevich A (2023)
Nucleic Acids ResDOI: 10.1093/nar/gkad1086
On the Transformation of LL(k)-linear to LL(1)-linear Grammars
Olkhovsky I, Okhotin A (2023)
Theory Comput Syst 67 (2): 234-262DOI: 10.1007/s00224-022-10108-6
WebQUAST: online evaluation of genome assemblies
Mikheenko A, Saveliev V, Hirsch P, Gurevich A (2023)
Nucleic Acids Res 51 (W1): 601-DOI: 10.1093/nar/gkad406
New Genetically Engineered Derivatives of Antibacterial Darobactins Underpin Their Potential for Antibiotic Development
Seyfert C, Müller A, Walsh D, Birkelbach J, Kany A, Porten C, Yuan B, Krug D, Herrmann J, Marlovits T, Hirsch A, Müller R (2023)
J. Med. Chem.DOI: 10.1021/acs.jmedchem.3c01660
Genome mining for macrolactam-encoding gene clusters allowed for the network-guided isolation of β-amino acid-containing cyclic derivatives and heterologous production of ciromicin A
Seibel E, Um S, Dayras M, Bodawatta K, Kruijff M, Jønsson K, Poulsen M, Kim K, Beemelmanns C (2023)
Commun Chem 6 (1): 1-15DOI: 10.1038/s42004-023-01034-w
Discovery and overproduction of novel highly bioactive pamamycins through transcriptional engineering of the biosynthetic gene cluster
Eckert N, Rebets Y, Horbal L, Zapp J, Herrmann J, Busche T, Müller R, Kalinowski J, Luzhetskyy A (2023)
Microb. Cell Fact. 22 (1)DOI: 10.1186/s12934-023-02231-x
1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding
Hamid R, Adam S, Lacour A, Monjas L, Köhnke J, Hirsch A (2023)
The Journal of biological chemistryDOI: 10.1016/j.jbc.2023.105152
NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner
Waqas F, Shehata M, Elgaher W, Lacour A, Kurmasheva N, Begnini F, Kiib A, Dahlmann J, Chen C, Pavlou A, …, Pleschka S, Pessler F (2023)
PLOS Pathogens 19 (7)DOI: 10.1371/journal.ppat.1011506
Disrupting Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latent Replication with a Small Molecule Inhibitor
Berwanger A, Stein S, Kany A, Gartner M, Loretz B, Lehr C, Hirsch A, Schulz T, Empting M (2023)
Journal of medicinal chemistry 66 (15): 10782-10790DOI: 10.1021/acs.jmedchem.3c00990
Tartrolon sensing and detoxification by the Listeria monocytogenes timABR resistance operon
Engelgeh T, Herrmann J, Jansen R, Müller R, Halbedel S (2023)
BookDOI: 10.1101/2023.07.27.550809
New Genetically Engineered Derivatives of Antibacterial Darobac-tins Underpin their Potential for Antibiotic Development
Seyfert C, Müller A, Walsh D, Birkelbach J, Kany A, Porten C, Yuan B, Krug D, Herrmann J, Marlovits T, Hirsch A, Müller R (2023)
BookDOI: 10.26434/chemrxiv-2023-24tmj
pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA
Liu Y, Ashmawy S, Latta L, Weiss A, Kiefer A, Nasr S, Loretz B, Hirsch A, Lee S, Lehr C (2023)
Biomacromolecules 24 (8): 3742-3754DOI: 10.1021/acs.biomac.3c00424
Isolation of sulfonosphingolipids from the rosette-inducing bacterium Zobellia uliginosa and evaluation of their rosette-inducing activity
Peng C, Dormanns N, Regestein L, Beemelmanns C (2023)
RSC Adv 13 (39): 27520-27524DOI: 10.1039/d3ra04314b
Artificial intelligence for natural product drug discovery
Mullowney M, Duncan K, Elsayed S, Garg N, van der Hooft J, Martin N, Meijer D, Terlouw B, Biermann F, Blin K, …, Robinson S, Medema M (2023)
Nat Rev Drug DiscovDOI: 10.1038/s41573-023-00774-7
Thermoresponsive cholesteric liquid-crystal systems doped with terpenoids as drug delivery systems for skin applications
Nesterkina M, Vashchenko O, Vashchenko P, Lisetski L, Kravchenko I, Hirsch A, Lehr C (2023)
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.VDOI: 10.1016/j.ejpb.2023.09.002
Impact of Drug Administration Routes on the In Vivo Efficacy of the Natural Product Sorangicin a Using a Staphylococcus aureus Infection Model in Zebrafish Embryos
Fries F, Kany A, Rasheed S, Hirsch A, Müller R, Herrmann J (2023)
International journal of molecular sciences 24 (16)DOI: 10.3390/ijms241612791
Zfp362 potentiates murine colonic inflammation by constraining Treg cell function rather than promoting Th17 cell differentiation
Herppich S, Hoenicke L, Kern F, Kruse F, Smout J, Greweling-Pils M, Geffers R, Burton O, Liston A, Keller A, Floess S, Huehn J (2023)
European journal of immunologyDOI: 10.1002/eji.202250270
Ageing-associated small RNA cargo of extracellular vesicles
Kern F, Kuhn T, Ludwig N, Simon M, Gröger L, Fabis N, Aparicio-Puerta E, Salhab A, Fehlmann T, Hahn O, …, Laschke M, Keller A (2023)
RNA biology 20 (1): 482-494DOI: 10.1080/15476286.2023.2234713
Optimization of Mass Spectrometry Imaging for Drug Metabolism and Distribution Studies in the Zebrafish Larvae Model: A Case Study with the Opioid Antagonist Naloxone
Park Y, Meyer M, Müller R, Herrmann J (2023)
International journal of molecular sciences 24 (12)DOI: 10.3390/ijms241210076
In Vitro Activity of Two Novel Antimicrobial Compounds on MDR-Resistant Clinical Isolates
Rima M, Pfennigwerth N, Cremanns M, Cirnski K, Oueslati S, Gatermann S, d’Amélio N, Herrmann J, Müller R, Naas T (2023)
Antibiotics 12 (8)DOI: 10.3390/antibiotics12081265
The mycobacterial ImuA'-ImuB-DnaE2 mutasome: composition and recruitment in live cells
Gessner S, Martin Z, Reiche M, Santos J, Dinkele R, Ramudzuli A, Dhar N, Wet T, Anoosheh S, Lang D, …, Lamers M, Warner D (2023)
eLife 12DOI: 10.7554/eLife.75628
Selective Activation of TRPC6 Ion Channel by Metallated Type-B Polyprenylated Polycyclic Acylphloroglucinols
Peslalz P, Kraus F, Izzo F, Bleisch A, El Hamdaoui Y, Schulz I, Kany A, Hirsch A, Friedland K, Plietker B (2023)
ManuscriptDOI: 10.26434/chemrxiv-2023-6w94r
Quantification of Plasmodium falciparum HRP-2 as an alternative method to 3Hhypoxanthine incorporation to measure the parasite reduction ratio in vitro
Carvalho L, Niepoth E, Mavraj-Husejni A, Kreidenweiss A, Herrmann J, Müller R, Knaab T, Burckhardt B, Kurz T, Held J (2023)
Int. J. Antimicrob. Agents 62 (3)DOI: 10.1016/j.ijantimicag.2023.106894
Schatztruhe Menschliches Mikrobiom: Wie Naturstoffe Uns Beeinflus...: Ingenta Connect
Schumm C, Donate P, Hegemann J, Keller A, Beemelmanns C, Müller R (2023)
Pharmakon 11 (4): 290-297DOI: 10.1691/pn.20230032
The Disorazole Z Family of Highly Potent Anticancer Natural Products from Sorangium cellulosum: Structure, Bioactivity, Biosynthesis, and Heterologous Expression
Gao Y, Birkelbach J, Fu C, Herrmann J, Irschik H, Morgenstern B, Hirschfelder K, Li R, Zhang Y, Jansen R, Müller R (2023)
Microbiology SpectrumDOI: 10.1128/spectrum.00730-23
Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation
Chan A, Ho T, Irfan R, Hamid R, Rudge E, Iqbal A, Turner A, Hirsch A., Leeper F (2023)
Bioorganic chemistry 138DOI: 10.1016/j.bioorg.2023.106602
Insights into the biosynthesis of icumazole, unveiling a distinctive family of crotonyl-CoA carboxylase/reductase
Xie F, Kiefer A, Hirsch A, Kalinina O, Fu C, Müller R (2023)
Cell Reports Physical Science 4 (5)DOI: 10.1016/j.xcrp.2023.101394
Engineered Biosynthesis of Complex Disorazol Polyketides in a Streamlined Burkholderia thailandensis
Wang Z, Liu X, Zhou H, Liu Y, Tu Q, Huo L, Yan F, Müller R, Zhang Y, Xu X (2023)
ACS synthetic biology 12 (4): 971-977DOI: 10.1021/acssynbio.2c00610
Genome-Guided Discovery of the Myxobacterial Thiolactone-Containing Sorangibactins
Gao Y, Walt C, Bader C, Müller R (2023)
ACS chemical biology 18 (4): 924-932DOI: 10.1021/acschembio.3c00063
Evaluation of extraction methods for untargeted metabolomic studies for future applications in zebrafish larvae infection models
Schippers P, Rasheed S, Park Y, Risch T, Wagmann L, Hemmer S, Manier S, Müller R, Herrmann J, Meyer M (2023)
Sci. Rep. 13 (1)DOI: 10.1038/s41598-023-34593-y
Facile Production of the Pseudomonas aeruginosa Virulence Factor LasB in E. coli for Structure-Based Drug Design
Kolling D, Haupenthal J, Hirsch A, Köhnke J (2023)
ChemBioChemDOI: 10.1002/cbic.202300185
Structure Elucidation and Biosynthesis of Nannosterols A and B, Myxobacterial Sterols from Nannocystis sp. MNa10993
Akone S, Hug J, Kaur A, Garcia R, Müller R (2023)
Journal of natural products 86 (4): 915-923DOI: 10.1021/acs.jnatprod.2c01143
Sorangicin A Is Active against Chlamydia in Cell Culture, Explanted Fallopian Tubes, and Topical In Vivo Treatment
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Antibiotics 12 (5)DOI: 10.3390/antibiotics12050795
miEAA 2023: updates, new functional microRNA sets and improved enrichment visualizations
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Nucleic Acids ResDOI: 10.1093/nar/gkad392
Isolation, (bio)synthetic studies and evaluation of antimicrobial properties of drimenol-type sesquiterpenes of Termitomyces fungi
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The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection
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Cell Host MicrobeDOI: 10.1016/j.chom.2023.04.003
Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate
Gawriljuk V, Oerlemans R, Gierse R, Jotwani R, Hirsch A, Groves M (2023)
Crystals 13 (5)DOI: 10.3390/cryst13050737
Adaptations of Pseudoxylaria towards a comb-associated lifestyle in fungus-farming termite colonies
Fricke J, Schalk F, Kreuzenbeck N, Seibel E, Hoffmann J, Dittmann G, Conlon B, Guo H, Wilhelm de Beer Z, Vassão D, …, Poulsen M, Beemelmanns C (2023)
ISME J.: 1-15DOI: 10.1038/s41396-023-01374-4
Multiple mutations in the Nav1.4 sodium channel of New Guinean toxic birds provide autoresistance to deadly batrachotoxin
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Mol. Ecol.DOI: 10.1111/mec.16878
Identification of Compounds Preventing A. fumigatus Biofilm Formation by Inhibition of the Galactosaminogalactan Deacetylase Agd3
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International journal of molecular sciences 24 (3)DOI: 10.3390/ijms24031851
Not Every Hit-Identification Technique Works on 1-Deoxy-d-Xylulose 5-Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign
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ChemMedChemDOI: 10.1002/cmdc.202200590
Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster
Nesterkina M, Bilokon S, Alieksieieva T, Kravchenko I, Hirsch A (2023)
Toxicol. Rep. 10DOI: 10.1016/j.toxrep.2023.02.009
Fighting antibiotic resistance-strategies and (pre)clinical developments to find new antibacterials
Walesch S, Birkelbach J, Jézéquel G, Haeckl F, Hegemann J, Hesterkamp T, Hirsch A, Hammann P, Müller R (2023)
EMBO reports 24 (1)DOI: 10.15252/embr.202256033
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle
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Neutralizing the Impact of the Virulence Factor LecA from Pseudomonas aeruginosa on Human Cells with New Glycomimetic Inhibitors
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Angewandte Chemie (International ed. in English) 62 (7)DOI: 10.1002/anie.202215535
Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization
Girardini M, Ferlenghi F, Annunziato G, Degiacomi G, Papotti B, Marchi C, Sammartino J, Rasheed S, Contini A, Pasca M, …, Costantino G, Pieroni M (2023)
European journal of medicinal chemistry 245DOI: 10.1016/j.ejmech.2022.114916