Publications
Publication Highlights
Have a look at our latest discoveries.
Publication database
2025
Saarvienin A - A Novel Glycopeptide with Potent Activity against Drug-resistant Bacteria
Kaur A, Guerrero-Garzón J, Rasheed S, Zehl M, Fries F, Morgenstern B, Zotchev S, Müller R (2025)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202425588
Natural products chlorotonils exert a complex antibacterial mechanism and address multiple targets
Deschner F, Mostert D, Daniel J, Voltz A, Schneider D, Khangholi N, Bartel J, Pessanha de Carvalho L, Brauer M, Gorelik T, …, Müller R, Herrmann J (2025)
Cell Chem. Biol.DOI: 10.1016/j.chembiol.2025.03.005
Innovative zinc-binding inhibitors of Legionella pneumophila ProA reduce collagen and flagellin degradation, TLR5 evasion, and human lung tissue inflammation
Scheithauer L, Ornago C, Selmar J, Schütz C, Bianchi G, Kiefer A, Haupenthal J, Dellmann A, Huynh D, Zhang R, …, Hirsch A, Steinert M (2025)
European journal of medicinal chemistry 296DOI: 10.1016/j.ejmech.2025.117832
Engineering an Artificial Myxopyronin Derivative with Enhanced Metabolic Stability via Mutasynthesis
Kiefer A, Voltz A, Scherzer D, Reberšek R, Kany A, Prosser G, Neuber M, Reiling N, Hirsch A, Müller R (2025)
40 Years of Natural Product Reports
Gulder T, Lim K (2025)
Nat. Prod. Rep. 42 (4): 647-648DOI: 10.1039/D5NP90012C
Chemical Proteomics Reveals Human Off-Targets of Fluoroquinolone Induced Mitochondrial Toxicity
Reinhardt T, El Harraoui Y, Rothemann A, Jauch A, Müller-Deubert S, Köllen M, Risch T, Jacobs L, Müller R, Traube F, …, Bach N, Sieber S (2025)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202421424
Postulations for the Migration Behavior of Amino Acids as Cations in Capillary Zone Electrophoresis
Gross P, Huber T, Lunow I, Burkhard D, Seelert H, Müller R (2025)
ElectrophoresisDOI: 10.1002/elps.202400205
ClpP2 proteasomes and SpxA1 determine Listeria monocytogenes tartrolon B hyper-resistance
Engelgeh T, Wamp S, Rothe P, Herrmann J, Fischer M, Müller R, Halbedel S (2025)
PLOS Genetics 21 (4)DOI: 10.1371/journal.pgen.1011621
The fungal natural product class of the sorbicillinoids: structures, bioactivities, biosynthesis, and synthesis
Milzarek T, Gulder T (2025)
Nat. Prod. Rep. 42: 482-500DOI: 10.1039/D4NP00059E
Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance
Rasheed S, Umstätter F, Mühlberg E, Beijer B, Hertlein T, Klika K, Kleist C, Werner J, Domhan C, Bingel M, …, Mier W, Uhl P (2025)
Adv. Therap.DOI: 10.1002/adtp.202400473
Gromomycins: An Unprecedented Class of Triterpene Antibiotics Produced by a Novel Biosynthetic Pathway
Luzhetskyy A, Tistechok S, Bratiichuk D, Sucipto H, Gummerlich N, Stierhof M, Fries F, Müller R, Zapp J, Myronovskyi M, Gromyko O, Fedorenko V (2025)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202422270
MIBiG 4.0: Advancing biosynthetic gene cluster curation through global collaboration
Zdouc M, Blin K, Louwen N, Navarro J, Loureiro C, Bader C, Bailey C, Barra L, Booth T, Bozhüyük K, …, Weber T, Medema M (2025)
Nucleic Acids Research 53 (D1): 678-690DOI: 10.1093/nar/gkae1115
Discovery of a novel, selective CK2 inhibitor class with an unusual basic scaffold
Khalifa H, ElHady A, Liu T, Elgaher W, Filhol-Cochet O, Cochet C, Abadi A, Hamed M, Abdel-Halim M, Engel M (2025)
European journal of medicinal chemistry 282DOI: 10.1016/j.ejmech.2024.117048
Heterologous Expression and Optimization of Fermentation Conditions for Recombinant Ikarugamycin Production
Evers J, Glöckle A, Wiegand M, Schuler S, Einsiedler M, Gulder T (2025)
Biotechnol. Bioeng. 122 (4): 974-982DOI: 10.1002/bit.28919
Homophenylalanine-derived benzo1,4diazepine-2,5-diones are strong bacterial quorum sensing inhibitors
Einsiedler M, Bogojevic S, Milivojevic D, Vojnovic S, Milcic M, Maslak V, Matura A, Gulder T, Nikodinovic-Runic J (2025)
Org. Biomol. Chem. 23 (4): 835-843DOI: 10.1039/d4ob01734j
Heterologous Expression of a Cryptic BGC from Bilophila sp. Provides Access to a Novel Family of Antibacterial Thiazoles
Hohmann M, Iliasov D, Larralde M, Johannes W, Janßen K, Zeller G, Mascher T, Gulder T (2025)
ACS Synth. Biol. 14 (3): 967-978DOI: 10.1021/acssynbio.5c00042
Expanding Polycyclic Tetramate Macrolactam (PoTeM) Core Structure Diversity by Chemo-Enzymatic Synthesis and Bioengineering
Schuler S, Einsiedler M, Evers J, Malay M, Uka V, Schneider S, Gulder T (2025)
Angew. Chem. Int. Ed. 64 (13)DOI: 10.1002/anie.202420335
A plug-and-play system for polycyclic tetramate macrolactam production and functionalization
Glöckle A, Schuler S, Einsiedler M, Gulder T (2025)
Microb. Cell Fact. 24 (1)DOI: 10.1186/s12934-024-02630-8
The Maculalactone Biosynthetic Gene Cluster, a Cryptic Furanolide Pathway Revealed in Nodularia sp. NIES-3585
D’Agostino P, Castro R, Uka V, Saurav K, Milzarek T, Sester A, Schneider M, Gulder T (2025)
bioRxivDOI: 10.1101/2025.02.26.640319
BGC Atlas: a web resource for exploring the global chemical diversity encoded in bacterial genomes
Bagci C, Nuhamunada M, Goyat H, Ladanyi C, Sehnal L, Blin K, Kautsar S, Tagirdzhanov A, Gurevich A, Mantri S, …, Weber T, Ziemert N (2025)
Nucleic Acids Res 53 (D1): 618-DOI: 10.1093/nar/gkae953
From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds
Keddis P, My Tu T, Scherer H, Kany A, Hafez D, Darwish S, Abadi A, Hirsch A, Engel M, Hamed M, Horng J, Abdel-Halim M (2025)
Eur. J. Med. Chem. 287DOI: 10.1016/j.ejmech.2025.117348
Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model
Kiefer A, Schütz C, Englisch C, Kolling D, Speicher S, Kany A, Shafiei R, Wadood N, Aljohmani A, Wirschem N, …, Haupenthal J, Hirsch A (2025)
Adv. Sci.DOI: 10.1002/advs.202411807
Unlocking the Antiviral Arsenal: Structure-Guided Optimization of Small-Molecule Inhibitors against RSV and hCoV-229E
Karhan C, Sake S, Gunesch A, Grethe C, Hellwinkel B, Köhler N, Kiefer A, Hapko U, Kany A, Pietschmann T, Hirsch A (2025)
European journal of medicinal chemistryDOI: 10.1016/j.ejmech.2025.117282
PEARL: Protein Eluting Alginate with Recombinant Lactobacilli
Tadimarri V, Blanch-Asensio M, Deshpande K, Baumann J, Baumann C, Müller R, Trujillo S, Sankaran S (2025)
Small (Weinheim an der Bergstrasse, Germany)DOI: 10.1002/smll.202408316
Uncovering the genetic basis of antiviral polyketide limocrocin biosynthesis through heterologous expression
Melnyk S, Stierhof M, Bratiichuk D, Fries F, Müller R, Rebets Y, Luzhetskyy A, Ostash B (2025)
Microb. Cell Fact. 24 (1)DOI: 10.1186/s12934-024-02621-9
Targeting IspD for Anti-infective and Herbicide Development: Exploring Its Role, Mechanism, and Structural Insights
Willocx D, Diamanti E, Hirsch A (2025)
Journal of medicinal chemistryDOI: 10.1021/acs.jmedchem.4c01146
Apo structure of Mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate synthase DXPS: Dynamics and implications for inhibitor design
Gawriljuk V, Alhayek A, Hirsch A, Groves M (2025)
Biochemical and Biophysical Research Communications 747DOI: 10.1016/j.bbrc.2024.151246
The PLSDB 2025 update: enhanced annotations and improved functionality for comprehensive plasmid research
Molano L, Hirsch P, Hannig M, Müller R, Keller A (2025)
Nucleic Acids Res 53 (D1): 189-DOI: 10.1093/nar/gkae1095
2024
High-Affinity Lectin Ligands Enable the Detection of Pathogenic Pseudomonas aeruginosa Biofilms: Implications for Diagnostics and Therapy
Zahorska E, Denig L, Lienenklaus S, Kuhaudomlarp S, Tschernig T, Lipp P, Munder A, Gillon E, Minervini S, Verkhova V, …, Wagner S, Titz A (2024)
JACS Au 4 (12): 4715-4728DOI: 10.1021/jacsau.4c00670
A fucose-binding superlectin from Enterobacter cloacae with high Lewis and ABO blood group antigen specificity
Beshr G, Sikandar A, Gläser J, Fares M, Sommer R, Wagner S, Köhnke J, Titz A (2024)
J. Biol. Chem.DOI: 10.1016/j.jbc.2024.108151
In Vivo Activity Profiling of Biosynthetic Darobactin D22 against Critical Gram-Negative Pathogens
Kany A, Fries F, Seyfert C, Porten C, Deckarm S, Chacón Ortiz M, Dubarry N, Vaddi S, Große M, Bernecker S, …, Herrmann J, Müller R (2024)
ACS Infect. Dis. 10 (12): 4337-4346DOI: 10.1021/acsinfecdis.4c00687
Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD
Willocx D, D'Auria L, Walsh D, Scherer H, Alhayek A, Hamed M, Borel F, Diamanti E, Hirsch A (2024)
Angew. Chem., Int. Ed. Engl.DOI: 10.1002/anie.202414615
Targeting Plasmodium falciparum IspD in the Methyl-d-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity
Willocx D, Bizzarri L, Alhayek A, Kannan D, Bravo P, Illarionov B, Rox K, Lohse J, Fischer M, Kany A, …, Diamanti E, Hirsch A (2024)
Journal of medicinal chemistry 67 (19): 17070-17086DOI: 10.1021/acs.jmedchem.4c00212
Autologous DNA mobilization and multiplication expedite natural products discovery from bacteria
Xie F, Zhao H, Liu J, Yang X, Neuber M, Agrawal A, Kaur A, Herrmann J, Kalinina O, Wei X, Müller R, Fu C (2024)
Science 386 (6727)DOI: 10.1126/science.abq7333
A New Class of Polyion Complex Vesicles (PIC-somes) to Improve Antimicrobial Activity of Tobramycin in Pseudomonas Aeruginosa Biofilms
Yildirim T, Bali A, Koch M, Paul P, Latta L, Schneider-Daum N, Gallei M, Lehr C (2024)
Small (Weinheim an der Bergstrasse, Germany) 20 (40)DOI: 10.1002/smll.202401926
A Novel 3D Printed Model of Infected Human Hair Follicles to Demonstrate Targeted Delivery of Nanoantibiotics
Aliyazdi S, Frisch S, Neu T, Veldung B, Karande P, Schaefer U, Loretz B, Vogt T, Lehr C (2024)
ACS biomaterials science & engineering 10 (8): 4947-4957DOI: 10.1021/acsbiomaterials.4c00570
Discovery of the Pendulisporaceae: An extremotolerant myxobacterial family with distinct sporulation behavior and prolific specialized metabolism
Garcia R, Popoff A, Bader C, Löhr J, Walesch S, Walt C, Boldt J, Bunk B, Haeckl F, Gunesch A, …, Bach T, Müller R (2024)
Chem 10: 1-20DOI: 10.1016/j.chempr.2024.04.019
Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application
Hofer W, Deschner F, Jézéquel G, Pessanha de Carvalho L, Abdel-Wadood N, Pätzold L, Bernecker S, Morgenstern B, Kany A, Große M, …, Herrmann J, Müller R (2024)
Angewandte Chemie (International ed. in English) 63 (19)DOI: 10.1002/anie.202319765
Dual inhibitors of Pseudomonas aeruginosa virulence factors LecA and LasB
Metelkina O, Konstantinovic J, Klein A, Shafiei R, Fares M, Alhayek A, Yahiaoui S, Elgaher W, Haupenthal J, Titz* A, Hirsch* A (2024)
Chem. Sci. 15DOI: 10.1039/D4SC02703E
Identification by Synthesis: Imidacins, Urocanate-Derived Alkaloids from the Myxobacterium Stigmatella aurantiaca
Kostka M, Krug D, Herrmann J, Dickschat J, Meyer J, Müller R, Schulz S (2024)
Org. Lett.DOI: 10.1021/acs.orglett.4c02036
SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination
Iram T, Garcia M, Amand J, Kaur A, Atkins M, Iyer M, Lam M, Ambiel N, Jorgens D, Keller A, …, Kern F, Zuchero J (2024)
Proc. Natl. Acad. Sci. U.S.A. 121 (12)DOI: 10.1073/pnas.2307250121
The Peptide Antibiotic Corramycin Adopts a β-Hairpin-like Structure and Is Inactivated by the Kinase ComG
Adam S, Fries F, Tesmar A, Rasheed S, Deckarm S, Sousa C, Reberšek R, Risch T, Mancini S, Herrmann J, …, Kalinina O, Müller R (2024)
J. Am. Chem. Soc.DOI: 10.1021/jacs.3c13208
ZEBRA: a hierarchically integrated gene expression atlas of the murine and human brain at single-cell resolution
Flotho M, Amand J, Hirsch P, Grandke F, Wyss-Coray T, Keller A, Kern F (2024)
Nucleic Acids Res 52 (D1): 1089-DOI: 10.1093/nar/gkad990
Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins
Fu C, Liu Y, Walt C, Rasheed S, Bader C, Lukat P, Neuber M, Haeckl F, Blankenfeldt W, Kalinina O, Müller R (2024)
Nat Commun 15 (1)DOI: 10.1038/s41467-024-44953-5
The underestimated fraction: diversity, challenges and novel insights into unicellular cyanobionts of lichens
Jung P, Briegel-Williams L, Büdel B, Schultz M, Nürnberg D, Grube M, D’Agostino P, Kaštovský J, Mareš J, Lorenz M, …, INCb, International Network for research on unicellular CyanoBionts from lichens (2024)
ISME Commun. 4 (1)DOI: 10.1093/ismeco/ycae069
Phylometagenomics of cycad coralloid roots reveals shared symbiotic signals
Bustos-Diaz E, Cruz-Perez A, Garfias-Gallegos D, D'Agostino P, Gehringer M, Cibrian-Jaramillo A, Barona-Gomez F (2024)
Microb. Genom. 10 (3)DOI: 10.1099/mgen.0.001207
S75 | CyanoMetDB | Comprehensive database of secondary metabolites from cyanobacteria - Version 03
Janssen E, Jones M, Pinto E, Dörr F, Torres M, Rios Jacinavicius F, Mazur-Marzec H, Szubert K, Konkel R, Tartaglione L, …, Reher R, Sieber S (2024)
BookDOI: 10.5281/zenodo.13854577
Citraconic acid and derivatives thereof for use as a medicament
Frank Pessler, Fangfang Chen, Moritz Winterhoff, Konrad Büssow, Wulf Blankenfeldt, Anna Hirsch, Walid A. M. Elgaher (2024)
Patent A61K31/122; A61K31/194; A61P31/16; C07C57/42; C07C61/20; C07C69/593; (US20240368065A1)
Author Correction: Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways
Kurmasheva N, Said A, Wong B, Kinderman P, Han X, Rahimic A, Kress A, Carter-Timofte M, Holm E, van der Horst D, …, Alain T, Olagnier D (2024)
Nat Commun 15 (1)DOI: 10.1038/s41467-024-55044-w
Novel and Extremely Sensitive NiAl2O4-NiO Nanostructures on an ITO Sensing Electrode for Enhanced Detection of Ascorbic Acid
Hammami A, Bardaoui A, Eissa S, Elgaher W, Chtourou R, Messaoud O (2024)
Molecules (Basel, Switzerland) 29 (12)DOI: 10.3390/molecules29122837
Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways
Kurmasheva N, Said A, Wong B, Kinderman P, Han X, Rahimic A, Kress A, Carter-Timofte M, Holm E, van der Horst D, …, Alain T, Olagnier D (2024)
Nat Commun 15 (1)DOI: 10.1038/s41467-024-48422-x
Chemoenzymatic total synthesis of sorbicillactone A
Müller J, Gulder T (2024)
Commun. Chem. 7 (1)DOI: 10.1038/s42004-024-01126-1
Biosynthesis of brevinic acid from lawsone
Hohmann M, Ohlrogge J, Gulder T (2024)
Org. Biomol. Chem. 22 (34): 7035-7038DOI: 10.1039/D4OB01184H
Product Selectivity in Baeyer-Villiger Monooxygenase-Catalyzed Bacterial Alkaloid Core Structure Maturation
Einsiedler M, Lamm K, Ohlrogge J, Schuler S, Richter I, Lübken T, Gulder T (2024)
J. Am. Chem. Soc. 146 (23): 16203-16212DOI: 10.1021/jacs.4c04115
Synthesis and antibiotic potential of myxocoumarin-inspired chromene dione analogs
Behnsen A, Hertrampf G, Vojnovic S, Nikodinovic-Runic J, Gulder T (2024)
RSC Adv. 14 (47): 35215-35219DOI: 10.1039/D4RA05941G
Decoding the diagnostic and therapeutic potential of microbiota using pan-body pan-disease microbiomics
Schmartz G, Rehner J, Gund M, Keller V, Molano L, Rupf S, Hannig M, Berger T, Flockerzi E, Seitz B, …, Bals R, Keller A (2024)
Nat. Commun. 15 (1)DOI: 10.1038/s41467-024-52598-7
Discovery and biosynthesis of non-canonical C16-terpenoids from Pseudomonas
Mo X, Pu Q, Lübken T, Yu G, Malay M, D'Agostino P, Gulder T (2024)
Cell Chem. Biol. 31 (12): 2128-2137DOI: 10.1016/j.chembiol.2024.09.002
Functionalization of silk with actinomycins from Streptomyces anulatus BV365 for biomedical applications
Ilic-Tomic T, Kramar A, Kostic M, Vojnovic S, Milovanovic J, Petkovic M, D'Agostino P, Gulder T, Nikodinovic-Runic J (2024)
Front. Bioeng. Biotechnol. 12DOI: 10.3389/fbioe.2024.1466757
Bacillamide D produced by Bacillus cereus from the mouse intestinal bacterial collection (miBC) is a potent cytotoxin in vitro
Hohmann M, Brunner V, Johannes W, Schum D, Carroll L, Liu T, Sasaki D, Bosch J, Clavel T, Sieber S, …, Janßen K, Gulder T (2024)
Commun. Biol. 7 (1)DOI: 10.1038/s42003-024-06208-3
Exploring microbial diversity and biosynthetic potential in zoo and wildlife animal microbiomes
Schmartz G, Rehner J, Schuff M, Molano L, Becker S, Krawczyk M, Tagirdzhanov A, Gurevich A, Francke R, Müller R, Keller V, Keller A (2024)
Nat Commun 15 (1)DOI: 10.1038/s41467-024-52669-9
The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity
Kalkreuter E, Kautsar S, Yang D, Bader C, Teijaro C, Fluegel L, Davis C, Simpson J, Lauterbach L, Steele A, …, Carvalho L, Shen B (2024)
bioRxivDOI: 10.1101/2023.12.14.571759
Evolution-inspired engineering of nonribosomal peptide synthetases
Bozhüyük K, Präve L, Kegler C, Schenk L, Kaiser S, Schelhas C, Shi Y, Kuttenlochner W, Schreiber M, Kandler J, …, Hochberg G, Bode H (2024)
Science 383 (6689)DOI: 10.1126/science.adg4320
Behavioral and electrophysiological responses of the male medfly, Ceratitis capitata, to thymol and carvacrol ethers
Tabanca N, Cloonan K, Nesterkina M, Gill M, Montgomery W, Kravchenko I, Kendra P (2024)
Pest management scienceDOI: 10.1002/ps.8324
Synthesis and Structure of a Coordination Polymer of Ni(II) with 2-(4-Bromophenoxy)acetohydrazide
Martsynko ?, Nesterkina M, Finik ?, Tsymbaliuk K, Dyakonenko V, Shishkina S, Kravchenko I (2024)
Molbank 2024 (2)DOI: 10.3390/M1819
Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes
Geißler A, Junca H, Kany A, Daumann L, Hirsch A, Pieper D, Sieber S (2024)
Chem. Sci. 15 (30): 11946-11955DOI: 10.1039/D4SC01940G
Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery**
Afanasenko A, Wu X, Santi A, Elgaher W, Kany A, Shafiei R, Schulze M, Schulz T, Haupenthal J, Hirsch A, Barta K (2024)
Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 136 (4)DOI: 10.1002/ange.202308131
Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity
Mielniczuk S, Hoff K, Baselious F, Li Y, Haupenthal J, Kany A, Riedner M, Rohde H, Rox K, Hirsch A, …, Sippl W, Holl R (2024)
Journal of medicinal chemistry 67 (19): 17363-17391DOI: 10.1021/acs.jmedchem.4c01262
Spray drying of a zinc complexing agent for inhalation therapy of pulmonary fibrosis
Stella J, Abdelaal M, Kamal M, Shehu K, Alhayek A, Haupenthal J, Hirsch A, Schneider M (2024)
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 202DOI: 10.1016/j.ejps.2024.106891
Journal of Medicinal Chemistry Collection: Drug Discovery in Germany
Laufer S, Gehringer M, Titz A (2024)
Journal of medicinal chemistry 67 (4)DOI: 10.1021/acs.jmedchem.4c00122
Glycomimetics as Candidates for Treatment and Prevention of Catheter-associated Biofilms Formed by Pseudomonas aeruginosa
Vogel C, Rox K, Wagenlehner F, Titz A (2024)
European urology focus 10 (5): 720-721DOI: 10.1016/j.euf.2024.08.011
Synthetic studies on the tetrasubstituted D-ring of cystobactamids lead to potent terephthalic acid antibiotics
Stappert M, Kohnhäuser D, Seedorf T, Coetzee J, Rox K, Fuchs H, Cirnski K, Leitner C, Herrmann J, Kirschning A, Müller R, Brönstrup M (2024)
Commun Chem 7 (1)DOI: 10.1038/s42004-024-01337-6
Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens
Fenwick M, Pierce P, Abendroth J, Barrett K, Barrett L, Bowatte K, Choi R, Chun I, Conrady D, Craig J, …, Edwards T, Myler P (2024)
Communications Biology 7 (1)DOI: 10.1038/s42003-024-07175-5
IspE kinase as an anti-infective target: Role of a hydrophobic pocket in inhibitor binding
Hamid R, Walsh D, Diamanti E, Aguilar D, Lacour A, Hamed M, Hirsch A (2024)
Structure (London, England : 1993) 32 (12): 2390-2398DOI: 10.1016/j.str.2024.10.009
Targeting the Plasmodium falciparum IspE Enzyme
Diamanti E, Steinbach A, Carvalho L, Ropponen H, Lacour A, Hamid R, Eisa S, Bravo P, Bousis S, Illarionov B, …, Sieber S, Hirsch A (2024)
ACS omega 9 (44): 44465-44473DOI: 10.1021/acsomega.4c06038
Expression and characterization of pantothenate energy-coupling factor transporters as an anti-infective drug target
Shams A, Bousis S, Diamanti E, Elgaher W, Zeimetz L, Haupenthal J, slotboom d, Hirsch A (2024)
Protein Sci. 33 (11)DOI: 10.1002/pro.5195
Studying Target-Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry
Bizzarri L, Steinbrunn D, Quennesson T, Lacour A, Bianchino G, Bravo P, Chaignon P, Lohse J, Mäser P, Seemann M, …, Hirsch A, Hahne H (2024)
ACS Infect. Dis. 10 (12): 4087-4102DOI: 10.1021/acsinfecdis.4c00417
Integral Solvent-Induced Protein Precipitation for Target-Engagement Studies in Plasmodium falciparum
Bravo P, Bizzarri L, Steinbrunn D, Lohse J, Hirsch A, Mäser P, Rottmann M, Hahne H (2024)
ACS Infect. Dis. 10 (12): 4073-4086DOI: 10.1021/acsinfecdis.4c00418
Dynamic Combinatorial Chemistry Unveils Nsp10 Inhibitors with Antiviral Potential Against SARS-CoV-2
Jumde R, Jézéquel G, Saramago M, Frank N, Adam S, Cunha M, Bader C, Gunesch A, Köhler N, Johannsen S, …, Arraiano C, Hirsch A (2024)
Chem. - Eur. J.DOI: 10.1002/chem.202403390
Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery
Liu Y, Hamm T, Eichinger T, Kamm W, Wieland H, Loretz B, Hirsch A, Lee S, Lehr C (2024)
Int. J. Nanomedicine 19: 4429-4449DOI: 10.2147/IJN.S448578
A stretchable human lung‐on‐chip model of alveolar inflammation for evaluating anti‐inflammatory drug response
Richter C, Latta L, Harig D, Carius P, Stucki J, Hobi N, Hugi A, Schumacher P, Krebs T, Gamrekeli A, …, Schneider-Daum N, Lehr C (2024)
Bioengineering & Transla MedDOI: 10.1002/btm2.10715
Design and evaluation of nanostructured lipid carrier of Bergenin isolated from Pentaclethra macrophylla for anti-inflammatory effect on lipopolysaccharide-induced inflammatory responses in macrophages
Nnamani P, Nwagwu C, Diovu E, Abonyi O, Nesterkina M, Neu T, Richter C, Loretz B, Lehr C (2024)
Eur J Pharm Biopharm 200DOI: 10.1016/j.ejpb.2024.114307
Biopolymeric and lipid-based nanotechnological strategies for the design and development of novel mosquito repellent systems: recent advances
Nwagwu C, Onugwu A, Echezona A, Uzondu S, Agbo C, Kenechukwu F, Ogbonna J, Ugorji L, Nwobi L, Nwobi O, …, Lehr C, Attama A (2024)
Nanoscale advances 6 (19): 4751-80DOI: 10.1039/d4na00474d
Identification of inhibitors targeting the energy-coupling factor (ECF) transporters
Diamanti E, Souza P, Setyawati I, Bousis S, Monjas L, Swier L, Shams A, Tsarenko A, Stanek W, Jäger M, …, slotboom d, Hirsch A (2024)
Communications Biology 7 (1)DOI: 10.1038/s42003-024-05770-0
Thermo-amplifier circuit in probiotic E. coli for stringently temperature-controlled release of a novel antibiotic
Dey S, Seyfert C, Fink-Straube C, Kany A, Müller R, Sankaran S (2024)
Journal of biological engineering 18 (1)DOI: 10.1186/s13036-024-00463-y
Olikomycin A-A Novel Calcium-Dependent Lipopeptide with Antibiotic Activity Against Multidrug-Resistant Bacteria
Makitrynskyy R, Keller L, Kaur A, Tsypik O, Munz L, Bechthold A, Müller R (2024)
Chem. Eur. J.DOI: 10.1002/chem.202403985
Structure Revision of Halisphingosine A via Total Synthesis and Bioactivity Studies
Sauer M, Kany A, Götze S, Müller R, Beemelmanns C (2024)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202416036
Realizing time-staggered expression of nucleic acid-encoded proteins by co-delivery of messenger RNA and plasmid DNA on a single nanocarrier
Nasr S, Paul P, Loretz B, Lehr C (2024)
Drug delivery and translational research 14 (12): 3339-3353DOI: 10.1007/s13346-024-01668-w
Harnessing Gram-negative bacteria for novel anti-Gram-negative antibiotics
Birkelbach J, Seyfert C, Walesch S, Müller R (2024)
Microbial Biotechnology 17 (11)DOI: 10.1111/1751-7915.70032
Comparative genomics unravels a rich set of biosynthetic gene clusters with distinct evolutionary trajectories across fungal species (Termitomyces) farmed by termites
Schmidt S, Murphy R, Vizueta J, Schierbech S, Conlon B, Kreuzenbeck N, Vreeburg S, van de Peppel L, Aanen D, Silué K, …, Weber T, Poulsen M (2024)
Commun Biol 7 (1)DOI: 10.1038/s42003-024-06887-y
Antimicrobial and antibiotic-potentiating effect of calcium peroxide nanoparticles on oral bacterial biofilms
Bankar N, Latta L, Loretz B, Reda B, Dudek J, Hähl H, Hannig M, Lehr C (2024)
npj Biofilms and Microbiomes 10 (1)DOI: 10.1038/s41522-024-00569-7
Interaction of the Atypical Tetracyclines Chelocardin and Amidochelocardin with Renal Drug Transporters
Rox K, Kühne A, Herrmann J, Jansen R, Hüttel S, Bernecker S, Hagos Y, Brönstrup M, Stadler M, Hesterkamp T, Müller R (2024)
ACS Pharmacol. Transl. Sci. 7 (7): 2093-2109DOI: 10.1021/acsptsci.4c00183
Bacteria from the Amycolatopsis genus associated with a toxic bird secrete protective secondary metabolites
Seibel E, Um S, Bodawatta K, Komor A, Decker T, Fricke J, Murphy R, Maiah G, Iova B, Maus H, …, Poulsen M, Beemelmanns C (2024)
Nat Commun 15 (1)DOI: 10.1038/s41467-024-52316-3
Statistical analysis of feature-based molecular networking results from non-targeted metabolomics data
Pakkir Shah A, Walter A, Ottosson F, Russo F, Navarro-Diaz M, Boldt J, Kalinski J, Kontou E, Elofson J, Polyzois A, …, Ernst M, Petras D (2024)
Nature protocolsDOI: 10.1038/s41596-024-01046-3
Optimization of the Central α-Amino Acid in Cystobactamids to the Broad-Spectrum, Resistance-Breaking Antibiotic CN-CC-861
Kohnhäuser D, Seedorf T, Cirnski K, Heimann D, Coetzee J, Sordello S, Richter J, Stappert M, Sabuco J, Corbett D, …, Kirschning A, Brönstrup M (2024)
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Isofunctional but Structurally Different Methyltransferases for Dithiolopyrrolone Diversification
Su L, Huber E, Westphalen M, Gellner J, Bode E, Köbel T, Grün P, Alanjary M, Glatter T, Cirnski K, …, Groll M, Bode H (2024)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202410799
The HIPS 2024 symposium: highlighting advances in pharmaceutical sciences in infection research
Mayoka G, Krug D, Loretz B, Bozhüyük K, Empting M, Hirsch A, Müller R (2024)
Trends in MicrobiologyDOI: 10.1016/j.tim.2024.07.007
Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE
Braun-Cornejo M, Ornago C, Sonawane V, Haupenthal J, Kany A, Diamanti E, Jézéquel G, Reiling N, Blankenfeldt W, Maas P, Hirsch A (2024)
ACS omegaDOI: 10.1021/acsomega.4c05537
Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes
Chan A, Ho T, Fathoni I, Hamid R, Hirsch A, Saliba K, Leeper F (2024)
RSC Med. Chem. 15 (5): 1773-1781DOI: 10.1039/D4MD00083H
Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes
Chen X, Zhao H, Wang C, Hamed M, Shang Q, Yang Y, Diao X, Sun X, Hu W, Jiang X, …, Wu D, Zhuang J (2024)
Int. J. Antimicrob. Agents 63 (5)DOI: 10.1016/j.ijantimicag.2024.107160
Arg-biodynamers as antibiotic potentiators through interacting with Gram-negative outer membrane lipopolysaccharides
Kamal M, Bassil J, Loretz B, Hirsch A, Lee S, Lehr C (2024)
Eur J Pharm Biopharm 200DOI: 10.1016/j.ejpb.2024.114336
AI is a viable alternative to high throughput screening: a 318-target study
Wallach I, Hirsch, Anna K. H. et al. (2024)
Sci Rep 14 (1)DOI: 10.1038/s41598-024-54655-z
Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain
Gawriljuk V, Godoy A, Oerlemans R, Welker L, Hirsch A, Groves M (2024)
Nat. Commun. 15 (1)DOI: 10.1038/s41467-024-50671-9
Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity
Abdelsamie A, Hamed M, Schütz C, Röhrig T, Kany A, Schmelz S, Blankenfeldt W, Hirsch A, Hartmann R, Empting M (2024)
Eur. J. Med. Chem. 276DOI: 10.1016/j.ejmech.2024.116685
Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms
Osbelt L, Almási É, Wende M, Kienesberger S, Voltz A, Lesker T, Muthukumarasamy U, Knischewski N, Nordmann E, Bielecka A, …, Zechner E, Strowig T (2024)
Nat. Microbiol. 9 (7): 1792-1811DOI: 10.1038/s41564-024-01710-0
Investigation of the Odilorhabdin Biosynthetic Gene Cluster Using NRPS Engineering
Präve L, Seyfert C, Bozhüyük K, Racine E, Müller R, Bode H (2024)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202406389
The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages
Mashayekhi V, Schomisch A, Rasheed S, Aparicio-Puerta E, Risch T, Yildiz D, Koch M, Both S, Ludwig N, Legroux T, …, Hoppstädter J, Kiemer A (2024)
Cell communication and signaling : CCS 22 (1)DOI: 10.1186/s12964-024-01701-y
Mibianto: ultra-efficient online microbiome analysis through k-mer based metagenomics
Hirsch P, Molano L, Engel A, Zentgraf J, Rahmann S, Hannig M, Müller R, Kern F, Keller A, Schmartz G (2024)
Nucleic Acids ResDOI: 10.1093/nar/gkae364
Thermotropic liquid crystals in drug delivery: A versatile carrier for controlled release
Nesterkina M, Kravchenko* I, Hirsch A, Lehr C (2024)
Eur. J. Pharm. Biopharm. 200DOI: 10.1016/j.ejpb.2024.114343
Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy-coupling factor transporters (ECFTs)
Haupenthal J, Rafehi M, Kany A, Lespine A, Stefan K, Hirsch* A, Stefan* S (2024)
Arch. Pharm.DOI: 10.1002/ardp.202400267
Molecular networking and computational NMR analyses uncover six polyketide-terpene hybrids from termite-associated Xylaria isolates
Lee S, Dayras M, Fricke J, Guo H, Balluff S, Schalk F, Yu J, Jeong S, Morgenstern B, Slippers B, Beemelmanns C, Kim K (2024)
Commun Chem 7 (1)DOI: 10.1038/s42004-024-01210-6
Genetic regulation of L-tryptophan metabolism in Psilocybe mexicana supports psilocybin biosynthesis
Seibold P, Dörner S, Fricke J, Schäfer T, Beemelmanns C, Hoffmeister D (2024)
Fungal biology and biotechnology 11 (1)DOI: 10.1186/s40694-024-00173-6
Metabolism and cytotoxicity studies of the two hallucinogens 1cP-LSD and 4-AcO-DET in human liver and zebrafish larvae models using LC-HRMS/MS and a high-content screening assay
Gampfer T, Schütz V, Schippers P, Rasheed S, Baumann J, Wagmann L, Pulver B, Westphal F, Flockerzi V, Müller R, Meyer M (2024)
Journal of pharmaceutical and biomedical analysis 245DOI: 10.1016/j.jpba.2024.116187
Point mutations in the ygiV promoter region lead to cystobactamid resistance and reduced virulence in E. coli
Müller R, Risch T, Kolling D, Mostert D, Seedorf T, Heimann D, Kohnhäuser D, Deschner F, Fries F, Solga D, …, Herrmann J, Sieber S (2024)
BookDOI: 10.21203/rs.3.rs-3751821/v1
Time series of chicken stool metagenomics and egg metabolomics in changing production systems: preliminary insights from a proof-of-concept
Rosch M, Rehner J, Schmartz G, Manier S, Becker U, Müller R, Meyer M, Keller A, Becker S, Keller V (2024)
One health outlook 6 (1)DOI: 10.1186/s42522-024-00100-0
Targeting Intracellular Bacteria with Dual Drug-loaded Lactoferrin Nanoparticles
Andima M, Boese A, Paul P, Koch M, Loretz B, Lehr C (2024)
ACS Infect. Dis.DOI: 10.1021/acsinfecdis.4c00045
Structure Revision of a Widespread Marine Sulfonolipid Class Based on Isolation and Total Synthesis
Roman D, Meisinger P, Guillonneau R, Peng C, Peltner L, Jordan P, Haensch V, Götze S, Werz O, Hertweck C, Chen Y, Beemelmanns C (2024)
Angew. Chem. Int. Ed.: 1433-7851DOI: 10.1002/anie.202401195
Antibiotic resistance and tolerance: What can drug delivery do against this global threat?
Aparicio-Blanco J, Vishwakarma N, Lehr C, Prestidge C, Thomas N, Roberts R, Thorn C, Melero A (2024)
Drug delivery and translational researchDOI: 10.1007/s13346-023-01513-6
Minimum Information for Conducting and Reporting In Vitro Intracellular Infection Assays
Subramaniam S, Joyce P, Ogunniyi A, Dube A, Sampson S, Lehr C, Prestidge C (2024)
ACS Infect. Dis. 10 (2): 337-349DOI: 10.1021/acsinfecdis.3c00613
Drug solubility in biorelevant media in the context of an inhalation-based biopharmaceutics classification system (iBCS)
Floroiu A, Loretz B, Krämer J, Lehr C (2024)
Eur J Pharm Biopharm 197DOI: 10.1016/j.ejpb.2024.114206
Biorelevant subcutaneous in vitro test predicts the release of human and fast acting insulin formulations
Schöner T, Vogel V, Venczel M, Knoth K, Kamm W, Paehler T, Louit G, Terán I, Mundinger P, Marker A, …, Hittinger M, Lehr C (2024)
Int. J. Pharm. 655DOI: 10.1016/j.ijpharm.2024.123995
Isolation of Fidaxomicin and Shunt Metabolites from Actinoplanes deccanensis
Jung E, Hunter M, Dorst A, Major A, Teofilovic T, Müller R, Gademann K (2024)
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Inhibitory effect of sorangicin A against mutant DNA-dependent RNA polymerase in the obligate intracellular bacterium Chlamydia trachomatis
Li Q, Jansen H, Hansen G, Nurjadi D, Herrmann J, Stadler M, Brönstrup M, Müller R, He C, Graspeuntner S, Rupp J, Shima K (2024)
Int. J. Antimicrob. AgentsDOI: 10.1016/j.ijantimicag.2024.107132
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity
Al-Saad O, Gabr M, Darwish S, Rullo M, Pisani L, Miniero D, Liuzzi G, Kany A, Hirsch A, Abadi A, …, Catto M, Abdel-Halim M (2024)
European journal of medicinal chemistryDOI: 10.1016/j.ejmech.2024.116266
Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence
Brand M, Ritzmann F, Kattler K, Milasius D, Yao Y, Herr C, Kirsch S, Müller R, Yildiz D, Bals R, Beisswenger C (2024)
Respir. Res. 25 (1)DOI: 10.1186/s12931-023-02636-7
A type III polyketide synthase cluster in the phylum Planctomycetota is involved in alkylresorcinol biosynthesis
Milke L, Kabuu M, Zschoche R, Gätgens J, Krumbach K, Carlstedt K, Wurzbacher C, Balluff S, Beemelmanns C, Jogler C, Marienhagen J, Kallscheuer N (2024)
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Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor
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High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum
Johannsen S, Gierse R, Krüger A, Edwards R, Nanna V, Fontana A, Di Zhu, Masini T, Carvalho L, Poizat M, …, Wrenger C, Hirsch* A (2024)
ACS Infect. Dis.DOI: 10.1021/acsinfecdis.3c00670
Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT
Exapicheidou I, Shams A, Ibrahim H, Tsarenko A, Backenköhler M, Hamed M, Diamanti E, Volkamer A, slotboom d, Hirsch A (2024)
Chem. Commun. 60 (7): 870-873DOI: 10.1039/D3CC04738E
Nitroxoline resistance is associated with significant fitness loss and diminishes in vivo virulence of Escherichia coli
Deschner F, Risch T, Baier C, Schlüter D, Herrmann J, Müller R (2024)
Microbiology Spectrum 12 (1)DOI: 10.1128/spectrum.03079-23
Is Simultaneous Binding to DNA and Gyrase Important for the Antibacterial Activity of Cystobactamids?
Solga D, Wieske L, Wilcox S, Zeilinger C, Jansen-Olliges L, Cirnski K, Herrmann J, Müller R, Erdelyi M, Kirschning A (2024)
Chem. Eur. J.DOI: 10.1002/chem.202303796
New myxobacteria of the Myxococcaceae clade produce angiolams with antiparasitic activities
Walesch S, Garcia R, Mahmoud A, Panter F, Bollenbach S, Mäser P, Kaiser M, Krug D, Müller R (2024)
Microbiology SpectrumDOI: 10.1128/spectrum.03689-23
Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents
Khalifa H, Rasheed S, Haupenthal J, Herrmann J, Mandour Y, Abadi A, Engel M, Müller R, Hirsch A, Abdel-Halim* M, Hamed* M (2024)
Archiv der PharmazieDOI: 10.1002/ardp.202300656
Mining the microbiota for antibiotics
Beemelmanns C, Keller A, Müller R (2024)
Nat. Microbiol. 9 (1): 13-14DOI: 10.1038/s41564-023-01568-8