Researchers in HIPS Laboratory


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Publication database


SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination

Iram T, Garcia M, Amand J, Kaur A, Atkins M, Iyer M, Lam M, Ambiel N, Jorgens D, Keller A, …, Kern F, Zuchero J (2024)

Proc. Natl. Acad. Sci. U.S.A. 121 (12)DOI: 10.1073/pnas.2307250121

The Peptide Antibiotic Corramycin Adopts a β-Hairpin-like Structure and Is Inactivated by the Kinase ComG

Adam S, Fries F, Tesmar A, Rasheed S, Deckarm S, Sousa C, Reberšek R, Risch T, Mancini S, Herrmann J, …, Kalinina O, Müller R (2024)

J. Am. Chem. Soc.DOI: 10.1021/jacs.3c13208

ZEBRA: a hierarchically integrated gene expression atlas of the murine and human brain at single-cell resolution

Flotho M, Amand J, Hirsch P, Grandke F, Wyss-Coray T, Keller A, Kern F (2024)

Nucleic Acids Res 52 (D1): 1089-DOI: 10.1093/nar/gkad990

Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins

Fu C, Liu Y, Walt C, Rasheed S, Bader C, Lukat P, Neuber M, Haeckl F, Blankenfeldt W, Kalinina O, Müller R (2024)

Nat Commun 15 (1)DOI: 10.1038/s41467-024-44953-5

Isolation of Fidaxomicin and Shunt Metabolites from Actinoplanes deccanensis

Jung E, Hunter M, Dorst A, Major A, Teofilovic T, Müller R, Gademann K (2024)

HCADOI: 10.1002/hlca.202400013

Inhibitory effect of sorangicin A against mutant DNA-dependent RNA polymerase in the obligate intracellular bacterium Chlamydia trachomatis

Li Q, Jansen H, Hansen G, Nurjadi D, Herrmann J, Stadler M, Brönstrup M, Müller R, He C, Graspeuntner S, Rupp J, Shima K (2024)

Int. J. Antimicrob. AgentsDOI: 10.1016/j.ijantimicag.2024.107132

Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity

Al-Saad O, Gabr M, Darwish S, Rullo M, Pisani L, Miniero D, Liuzzi G, Kany A, Hirsch A, Abadi A, …, Catto M, Abdel-Halim M (2024)

European journal of medicinal chemistryDOI: 10.1016/j.ejmech.2024.116266

Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence

Brand M, Ritzmann F, Kattler K, Milasius D, Yao Y, Herr C, Kirsch S, Müller R, Yildiz D, Bals R, Beisswenger C (2024)

Respir. Res. 25 (1)DOI: 10.1186/s12931-023-02636-7

A type III polyketide synthase cluster in the phylum Planctomycetota is involved in alkylresorcinol biosynthesis

Milke L, Kabuu M, Zschoche R, Gätgens J, Krumbach K, Carlstedt K, Wurzbacher C, Balluff S, Beemelmanns C, Jogler C, Marienhagen J, Kallscheuer N (2024)

Appl Microbiol Biotechnol 108 (1)DOI: 10.1007/s00253-024-13065-x

Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor

Sake S, Zhang X, Rajak M, Urbanek-Quaing M, Carpentier A, Gunesch A, Grethe C, Matthaei A, Rückert J, Galloux M, …, Haid S, Pietschmann T (2024)

Nat. Commun. 15 (1)DOI: 10.1038/s41467-024-45241-y

High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum

Johannsen S, Gierse R, Krüger A, Edwards R, Nanna V, Fontana A, Di Zhu, Masini T, Carvalho L, Poizat M, …, Wrenger C, Hirsch A (2024)

ACS Infect. Dis.DOI: 10.1021/acsinfecdis.3c00670

Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT

Exapicheidou I, Shams A, Ibrahim H, Tsarenko A, Backenköhler M, Hamed M, Diamanti E, Volkamer A, slotboom d, Hirsch A (2024)

Chem. Commun. 60 (7): 870-873DOI: 10.1039/D3CC04738E

Nitroxoline resistance is associated with significant fitness loss and diminishes in vivo virulence of Escherichia coli

Deschner F, Risch T, Baier C, Schlüter D, Herrmann J, Müller R (2024)

Microbiology Spectrum 12 (1)DOI: 10.1128/spectrum.03079-23

Is Simultaneous Binding to DNA and Gyrase Important for the Antibacterial Activity of Cystobactamids?

Solga D, Wieske L, Wilcox S, Zeilinger C, Jansen-Olliges L, Cirnski K, Herrmann J, Müller R, Erdelyi M, Kirschning A (2024)

Chem. Eur. J.DOI: 10.1002/chem.202303796

New myxobacteria of the Myxococcaceae clade produce angiolams with antiparasitic activities

Walesch S, Garcia R, Mahmoud A, Panter F, Bollenbach S, Mäser P, Kaiser M, Krug D, Müller R (2024)

Microbiology SpectrumDOI: 10.1128/spectrum.03689-23

Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents

Khalifa H, Rasheed S, Haupenthal J, Herrmann J, Mandour Y, Abadi A, Engel M, Müller R, Hirsch A, Abdel-Halim M, Hamed M (2024)

Archiv der PharmazieDOI: 10.1002/ardp.202300656

Mining the microbiota for antibiotics

Beemelmanns C, Keller A, Müller R (2024)

Nat. Microbiol. 9 (1): 13-14DOI: 10.1038/s41564-023-01568-8


Heterologous expression of the cryptic mdk gene cluster and structural revision of maduralactomycin A

Schwitalla J, Le N, Um S, Schalk F, Brönstrup M, Baunach M, Beemelmanns C (2023)

RSC Adv 13 (48): 34136-34144DOI: 10.1039/D3RA05931F

Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery

Afanasenko A, Wu X, Santi A, Elgaher W, Kany A, Shafiei R, Schulze M, Schulz T, Haupenthal J, Hirsch A, Barta K (2023)

Angew. Chem. Int. Ed.DOI: 10.1002/anie.202308131

Identification of HuR–RNA Interfering Compounds by Dynamic Combinatorial Chemistry and Fluorescence Polarization

Della Volpe S, Listro R, Ambrosio F, Garbagnoli M, Linciano P, Rossi D, Costa G, Alcaro S, Vasile F, Hirsch A, Collina S (2023)

ACS Med. Chem. Lett.DOI: 10.1021/acsmedchemlett.3c00303

Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors

Ropponen H, Diamanti E, Johannsen S, Illarionov B, Hamid R, Jaki M, Sass P, Fischer M, Haupenthal J, Hirsch A (2023)

ChemMedChemDOI: 10.1002/cmdc.202300346

Inhibitors of the Elastase LasB for the treatment of Pseudomonas aeruginosa lung infections

Konstantinovic J, Kany A, Alhayek A, Abdelsamie A, Sikandar A, Voos K, Yao Y, Andreas A, Shafiei R, Loretz B, …, Haupenthal J, Hirsch A (2023)

DOI: 10.26434/chemrxiv-2023-bszcb

Atlas of the aging mouse brain reveals white matter as vulnerable foci

Hahn O, Foltz A, Atkins M, Kedir B, Moran-Losada P, Guldner I, Munson C, Kern F, Pálovics R, Lu N, …, Keller A, Wyss-Coray T (2023)

CellDOI: 10.1016/j.cell.2023.07.027

Revision of the Absolute Configurations of Chelocardin and Amidochelocardin

Sikandar A, Popoff A, Jumde R, Mándi A, Kaur A, Elgaher W, Rosenberger L, Hüttel S, Jansen R, Hunter M, …, Kurtán T, Müller R (2023)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202306437

Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis

Adam S, Zheng D, Klein A, Volz C, Mullen W, Shirran S, Smith B, Kalinina O, Müller R, Koehnke J (2023)

Nature chemistry 15 (4): 560-568DOI: 10.1038/s41557-023-01153-w

Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues

Wagner V, Kern F, Hahn O, Schaum N, Ludwig N, Fehlmann T, Engel A, Henn D, Rishik S, Isakova A, …, Wyss-Coray T, Keller A (2023)

Nat BiotechnolDOI: 10.1038/s41587-023-01751-6

Synthesis of Aryl‐ and Alkyl‐Containing 3‐Methylene‐5‐hydroxy Esters via a Barbier Allylation Reaction

Bartholomäus A, Roman D, Al-Jammal W, Vilotijevic I, Beemelmanns C (2023)

Eur. J. Org. Chem.DOI: 10.1002/ejoc.202300177

The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition

Koller T, Scheid U, Kösel T, Herrmann J, Krug D, Boshoff H, Beckert B, Evans J, Schlemmer J, Sloan B, …, Wilson D, Müller R (2023)

J. Am. Chem. Soc. 145 (2): 851-863DOI: 10.1021/jacs.2c08816

3D bioprinting ofE. coliMG1655 biofilms on human lung epithelial cells for building complexin vitroinfection models

Aliyazdi S, Frisch S, Hidalgo A, Frank N, Krug D, Müller R, Schaefer U, Vogt T, Loretz B, Lehr C (2023)

Biofabrication 15 (3)DOI: 10.1088/1758-5090/acd95e

Discovery and Characterization of a Myxobacterial Lanthipeptide with Unique Biosynthetic Features and Anti-inflammatory Activity

Wang X, Chen X, Wang Z, Zhuang M, Zhong L, Fu C, Garcia R, Müller R, Zhang Y, Yan J, Wu D, Huo L (2023)

J. Am. Chem. Soc. 145 (30): 16924-16937DOI: 10.1021/jacs.3c06014

The resuscitation-promoting factor (Rpf) from Micrococcus luteus and its putative reaction product 1,6-anhydro-MurNAc increase culturability of environmental bacteria

Guzman J, Raval D, Hauck D, Titz A, Poehlein A, Degenkolb T, Daniel R, Vilcinskas A (2023)

Access microbiology 5 (9)DOI: 10.1099/acmi.0.000647.v4

Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(III) glycoconjugate systems

Wojtczak K, Zahorska E, Murphy I, Koppel F, Cooke G, Titz A, Byrne J (2023)

Chem. Commun. (Cambridge, U. K.) 59 (54): 8384-8387DOI: 10.1039/D3CC02300A

Pseudomonas aeruginosa LecB suppresses immune responses by inhibiting transendothelial migration

Sponsel J, Guo Y, Hamzam L, Lavanant A, Pérez-Riverón A, Partiot E, Muller Q, Rottura J, Gaudin R, Hauck D, …, Römer W, Mueller C (2023)

EMBO reports 24 (4)DOI: 10.15252/embr.202255971

Tackling the outer membrane: facilitating compound entry into Gram-negative bacterial pathogens

Saxena D, Maitra R, Bormon R, Czekanska M, Meiers J, Titz A, Verma S, Chopra S (2023)

npj Antimicrob Resist 1 (1)DOI: 10.1038/s44259-023-00016-1

Glycomimetics for the inhibition and modulation of lectins

Leusmann S, Ménová P, Shanin E, Titz A, Rademacher C (2023)

Chem. Soc. Rev. 52 (11): 3663-3740DOI: 10.1039/d2cs00954d

Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections

Konstantinovic J, Kany A, Alhayek A, Abdelsamie A, Sikandar A, Voos K, Yao Y, Andreas A, Shafiei R, Loretz B, …, Haupenthal J, Hirsch A (2023)

ACS Cent. Sci. 9 (12): 2205-2215DOI: 10.1021/acscentsci.3c01102

Molecular replacement for small-molecule crystal structure determination from X-ray and electron diffraction data with reduced resolution

Gorelik T, Lukat P, Kleeberg C, Blankenfeldt W, Mueller R (2023)

Acta crystallographica. Section A, Foundations and advances 79 (Pt 6): 504-514DOI: 10.1107/S2053273323008458

ABC-HuMi: the Atlas of Biosynthetic Gene Clusters in the Human Microbiome

Hirsch P, Tagirdzhanov A, Kushnareva A, Olkhovskii I, Graf S, Schmartz G, Hegemann J, Bozhüyük K, Rolf M, Keller A, Gurevich A (2023)

BookDOI: 10.1101/2023.09.18.558305

Darobactine: eine neue Antibiotikaklasse in Entwicklung

Seyfert C, Porten C, Müller R (2023)

Biospektrum 29 (5): 539-541DOI: 10.1007/s12268-023-1988-6

Resolution of eleven reported and five novel Podaxis species based on ITS phylogeny, phylogenomics, morphology, ecology, and geographic distribution

Li G, Leal-Dutra C, Cuesta-Maté A, Conlon B, Peereboom N, Beemelmanns C, Aanen D, Rosendahl S, Debeer Z, Poulsen M (2023)

Persoonia (Molecular Phylogeny and Evolution of Fungi) 51: 257-279DOI: 10.3767/persoonia.2023.51.07

On the Transformation of LL(k)-linear to LL(1)-linear Grammars

Olkhovsky I, Okhotin A (2023)

Theory Comput Syst 67 (2): 234-262DOI: 10.1007/s00224-022-10108-6

WebQUAST: online evaluation of genome assemblies

Mikheenko A, Saveliev V, Hirsch P, Gurevich A (2023)

Nucleic Acids Res 51 (W1): 601-DOI: 10.1093/nar/gkad406

HypoRiPPAtlas as an Atlas of hypothetical natural products for mass spectrometry database search

Lee Y, Guler M, Chigumba D, Wang S, Mittal N, Miller C, Krummenacher B, Liu H, Cao L, Kannan A, …, Kersten R, Mohimani H (2023)

Nat Commun 14 (1)DOI: 10.1038/s41467-023-39905-4

ABC-HuMi: the Atlas of Biosynthetic Gene Clusters in the Human Microbiome

Hirsch P, Tagirdzhanov A, Kushnareva A, Olkhovskii I, Graf S, Schmartz G, Hegemann J, Bozhüyük K, Müller R, Keller A, Gurevich A (2023)

Nucleic Acids ResDOI: 10.1093/nar/gkad1086

New Genetically Engineered Derivatives of Antibacterial Darobactins Underpin Their Potential for Antibiotic Development

Seyfert C, Müller A, Walsh D, Birkelbach J, Kany A, Porten C, Yuan B, Krug D, Herrmann J, Marlovits T, Hirsch A, Müller R (2023)

J. Med. Chem.DOI: 10.1021/acs.jmedchem.3c01660

Genome mining for macrolactam-encoding gene clusters allowed for the network-guided isolation of β-amino acid-containing cyclic derivatives and heterologous production of ciromicin A

Seibel E, Um S, Dayras M, Bodawatta K, Kruijff M, Jønsson K, Poulsen M, Kim K, Beemelmanns C (2023)

Commun Chem 6 (1): 1-15DOI: 10.1038/s42004-023-01034-w

Discovery and overproduction of novel highly bioactive pamamycins through transcriptional engineering of the biosynthetic gene cluster

Eckert N, Rebets Y, Horbal L, Zapp J, Herrmann J, Busche T, Müller R, Kalinowski J, Luzhetskyy A (2023)

Microb. Cell Fact. 22 (1)DOI: 10.1186/s12934-023-02231-x

1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding

Hamid R, Adam S, Lacour A, Monjas L, Köhnke J, Hirsch A (2023)

The Journal of biological chemistryDOI: 10.1016/j.jbc.2023.105152

NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner

Waqas F, Shehata M, Elgaher W, Lacour A, Kurmasheva N, Begnini F, Kiib A, Dahlmann J, Chen C, Pavlou A, …, Pleschka S, Pessler F (2023)

PLOS Pathogens 19 (7)DOI: 10.1371/journal.ppat.1011506

Disrupting Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latent Replication with a Small Molecule Inhibitor

Berwanger A, Stein S, Kany A, Gartner M, Loretz B, Lehr C, Hirsch A, Schulz T, Empting M (2023)

Journal of medicinal chemistry 66 (15): 10782-10790DOI: 10.1021/acs.jmedchem.3c00990

Tartrolon sensing and detoxification by the Listeria monocytogenes timABR resistance operon

Engelgeh T, Herrmann J, Jansen R, Müller R, Halbedel S (2023)

BookDOI: 10.1101/2023.07.27.550809

New Genetically Engineered Derivatives of Antibacterial Darobac-tins Underpin their Potential for Antibiotic Development

Seyfert C, Müller A, Walsh D, Birkelbach J, Kany A, Porten C, Yuan B, Krug D, Herrmann J, Marlovits T, Hirsch A, Müller R (2023)

BookDOI: 10.26434/chemrxiv-2023-24tmj

pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA

Liu Y, Ashmawy S, Latta L, Weiss A, Kiefer A, Nasr S, Loretz B, Hirsch A, Lee S, Lehr C (2023)

Biomacromolecules 24 (8): 3742-3754DOI: 10.1021/acs.biomac.3c00424

Isolation of sulfonosphingolipids from the rosette-inducing bacterium Zobellia uliginosa and evaluation of their rosette-inducing activity

Peng C, Dormanns N, Regestein L, Beemelmanns C (2023)

RSC Adv 13 (39): 27520-27524DOI: 10.1039/d3ra04314b

Artificial intelligence for natural product drug discovery

Mullowney M, Duncan K, Elsayed S, Garg N, van der Hooft J, Martin N, Meijer D, Terlouw B, Biermann F, Blin K, …, Robinson S, Medema M (2023)

Nat Rev Drug DiscovDOI: 10.1038/s41573-023-00774-7

Thermoresponsive cholesteric liquid-crystal systems doped with terpenoids as drug delivery systems for skin applications

Nesterkina M, Vashchenko O, Vashchenko P, Lisetski L, Kravchenko I, Hirsch A, Lehr C (2023)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.VDOI: 10.1016/j.ejpb.2023.09.002

Impact of Drug Administration Routes on the In Vivo Efficacy of the Natural Product Sorangicin a Using a Staphylococcus aureus Infection Model in Zebrafish Embryos

Fries F, Kany A, Rasheed S, Hirsch A, Müller R, Herrmann J (2023)

International journal of molecular sciences 24 (16)DOI: 10.3390/ijms241612791

Zfp362 potentiates murine colonic inflammation by constraining Treg cell function rather than promoting Th17 cell differentiation

Herppich S, Hoenicke L, Kern F, Kruse F, Smout J, Greweling-Pils M, Geffers R, Burton O, Liston A, Keller A, Floess S, Huehn J (2023)

European journal of immunologyDOI: 10.1002/eji.202250270

Ageing-associated small RNA cargo of extracellular vesicles

Kern F, Kuhn T, Ludwig N, Simon M, Gröger L, Fabis N, Aparicio-Puerta E, Salhab A, Fehlmann T, Hahn O, …, Laschke M, Keller A (2023)

RNA biology 20 (1): 482-494DOI: 10.1080/15476286.2023.2234713

Optimization of Mass Spectrometry Imaging for Drug Metabolism and Distribution Studies in the Zebrafish Larvae Model: A Case Study with the Opioid Antagonist Naloxone

Park Y, Meyer M, Müller R, Herrmann J (2023)

International journal of molecular sciences 24 (12)DOI: 10.3390/ijms241210076

In Vitro Activity of Two Novel Antimicrobial Compounds on MDR-Resistant Clinical Isolates

Rima M, Pfennigwerth N, Cremanns M, Cirnski K, Oueslati S, Gatermann S, d’Amélio N, Herrmann J, Müller R, Naas T (2023)

Antibiotics 12 (8)DOI: 10.3390/antibiotics12081265

The mycobacterial ImuA'-ImuB-DnaE2 mutasome: composition and recruitment in live cells

Gessner S, Martin Z, Reiche M, Santos J, Dinkele R, Ramudzuli A, Dhar N, Wet T, Anoosheh S, Lang D, …, Lamers M, Warner D (2023)

eLife 12DOI: 10.7554/eLife.75628

Selective Activation of TRPC6 Ion Channel by Metallated Type-B Polyprenylated Polycyclic Acylphloroglucinols

Peslalz P, Kraus F, Izzo F, Bleisch A, El Hamdaoui Y, Schulz I, Kany A, Hirsch A, Friedland K, Plietker B (2023)

ManuscriptDOI: 10.26434/chemrxiv-2023-6w94r

Quantification of Plasmodium falciparum HRP-2 as an alternative method to 3Hhypoxanthine incorporation to measure the parasite reduction ratio in vitro

Carvalho L, Niepoth E, Mavraj-Husejni A, Kreidenweiss A, Herrmann J, Müller R, Knaab T, Burckhardt B, Kurz T, Held J (2023)

Int. J. Antimicrob. Agents 62 (3)DOI: 10.1016/j.ijantimicag.2023.106894

Schatztruhe Menschliches Mikrobiom: Wie Naturstoffe Uns Beeinflus...: Ingenta Connect

Schumm C, Donate P, Hegemann J, Keller A, Beemelmanns C, Müller R (2023)

Pharmakon 11 (4): 290-297DOI: 10.1691/pn.20230032

The Disorazole Z Family of Highly Potent Anticancer Natural Products from Sorangium cellulosum: Structure, Bioactivity, Biosynthesis, and Heterologous Expression

Gao Y, Birkelbach J, Fu C, Herrmann J, Irschik H, Morgenstern B, Hirschfelder K, Li R, Zhang Y, Jansen R, Müller R (2023)

Microbiology SpectrumDOI: 10.1128/spectrum.00730-23

Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation

Chan A, Ho T, Irfan R, Hamid R, Rudge E, Iqbal A, Turner A, Hirsch A., Leeper F (2023)

Bioorganic chemistry 138DOI: 10.1016/j.bioorg.2023.106602

Insights into the biosynthesis of icumazole, unveiling a distinctive family of crotonyl-CoA carboxylase/reductase

Xie F, Kiefer A, Hirsch A, Kalinina O, Fu C, Müller R (2023)

Cell Reports Physical Science 4 (5)DOI: 10.1016/j.xcrp.2023.101394

Engineered Biosynthesis of Complex Disorazol Polyketides in a Streamlined Burkholderia thailandensis

Wang Z, Liu X, Zhou H, Liu Y, Tu Q, Huo L, Yan F, Müller R, Zhang Y, Xu X (2023)

ACS synthetic biology 12 (4): 971-977DOI: 10.1021/acssynbio.2c00610

Genome-Guided Discovery of the Myxobacterial Thiolactone-Containing Sorangibactins

Gao Y, Walt C, Bader C, Müller R (2023)

ACS chemical biology 18 (4): 924-932DOI: 10.1021/acschembio.3c00063

Evaluation of extraction methods for untargeted metabolomic studies for future applications in zebrafish larvae infection models

Schippers P, Rasheed S, Park Y, Risch T, Wagmann L, Hemmer S, Manier S, Müller R, Herrmann J, Meyer M (2023)

Sci. Rep. 13 (1)DOI: 10.1038/s41598-023-34593-y

Facile Production of the Pseudomonas aeruginosa Virulence Factor LasB in E. coli for Structure-Based Drug Design

Kolling D, Haupenthal J, Hirsch A, Köhnke J (2023)

ChemBioChemDOI: 10.1002/cbic.202300185

Structure Elucidation and Biosynthesis of Nannosterols A and B, Myxobacterial Sterols from Nannocystis sp. MNa10993

Akone S, Hug J, Kaur A, Garcia R, Müller R (2023)

Journal of natural products 86 (4): 915-923DOI: 10.1021/acs.jnatprod.2c01143

Sorangicin A Is Active against Chlamydia in Cell Culture, Explanted Fallopian Tubes, and Topical In Vivo Treatment

Graspeuntner S, Koethke K, Scholz C, Semmler L, Lupatsii M, Kirchhoff L, Herrmann J, Rox K, Wittstein K, Käding N, …, Shima K, Rupp J (2023)

Antibiotics 12 (5)DOI: 10.3390/antibiotics12050795

miEAA 2023: updates, new functional microRNA sets and improved enrichment visualizations

Aparicio-Puerta E, Hirsch P, Schmartz G, Kern F, Fehlmann T, Keller A (2023)

Nucleic Acids ResDOI: 10.1093/nar/gkad392

Isolation, (bio)synthetic studies and evaluation of antimicrobial properties of drimenol-type sesquiterpenes of Termitomyces fungi

Kreuzenbeck N, Dhiman S, Roman D, Burkhardt I, Conlon B, Fricke J, Guo H, Blume J, Görls H, Poulsen M, …, Arndt H, Beemelmanns C (2023)

Commun Chem 6 (1)DOI: 10.1038/s42004-023-00871-z

The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection

Bublitz A, Brauer M, Wagner S, Hofer W, Müsken M, Deschner F, Lesker T, Neumann-Schaal M, Paul L, Nübel U, …, Fuchs T, Strowig T (2023)

Cell Host MicrobeDOI: 10.1016/j.chom.2023.04.003

Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate

Gawriljuk V, Oerlemans R, Gierse R, Jotwani R, Hirsch A, Groves M (2023)

Crystals 13 (5)DOI: 10.3390/cryst13050737

Adaptations of Pseudoxylaria towards a comb-associated lifestyle in fungus-farming termite colonies

Fricke J, Schalk F, Kreuzenbeck N, Seibel E, Hoffmann J, Dittmann G, Conlon B, Guo H, Wilhelm de Beer Z, Vassão D, …, Poulsen M, Beemelmanns C (2023)

ISME J.: 1-15DOI: 10.1038/s41396-023-01374-4

Multiple mutations in the Nav1.4 sodium channel of New Guinean toxic birds provide autoresistance to deadly batrachotoxin

Bodawatta K, Hu H, Schalk F, Daniel J, Maiah G, Koane B, Iova B, Beemelmanns C, Poulsen M, Jønsson K (2023)

Mol. Ecol.DOI: 10.1111/mec.16878

Identification of Compounds Preventing A. fumigatus Biofilm Formation by Inhibition of the Galactosaminogalactan Deacetylase Agd3

Seegers C, Lee D, Zarnovican P, Kirsch S, Müller R, Haselhorst T, Routier F (2023)

International journal of molecular sciences 24 (3)DOI: 10.3390/ijms24031851

Not Every Hit-Identification Technique Works on 1-Deoxy-d-Xylulose 5-Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign

Johannsen S, Gierse R, Olshanova A, Smerznak E, Laggner C, Eschweiler L, Adeli Z, Hamid R, Alhayek A, Reiling N, Haupenthal J, Hirsch A (2023)

ChemMedChemDOI: 10.1002/cmdc.202200590

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