Publications
Publication Highlights
Have a look at our latest discoveries.
Publication database
2020
PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus
Anversa Dimer F, Souza Carvalho-Wodarz C, Goes A, Cirnski K, Herrmann J, Schmitt V, Pätzold L, Abed N, Rossi C, Bischoff M, …, Müller R, Lehr C (2020)
Nanomedicine : nanotechnology, biology, and medicine, 24DOI: 10.1016/j.nano.2019.102125
Probiomimetics-Novel Lactobacillus-Mimicking Microparticles Show Anti-Inflammatory and Barrier-Protecting Effects in Gastrointestinal Models
Kuhn T, Koch M, Fuhrmann G (2020)
Small (Weinheim an der Bergstrasse, Germany)DOI: 10.1002/smll.202003158
Discovery of Antibacterial Agents Inhibiting the Energy-Coupling Factor (ECF) Transporters by Structure-Based Virtual Screening
Diamanti E, Setyawati I, Bousis S, mojas l, Swier l, Haupenthal J, Gibson P, Volz C, stanek w, Jaeger m, …, slotboom d, Hirsch A (2020)
BookDOI: 10.26434/chemrxiv.11728710.v1
Streptococcal Extracellular Membrane Vesicles Are Rapidly Internalized by Immune Cells and Alter Their Cytokine Release
Mehanny M, Koch M, Lehr C, Fuhrmann G (2020)
Frontiers in immunology, 11DOI: 10.3389/fimmu.2020.00080
Dual-function chromogenic screening-based CRISPR/Cas9 genome editing system for actinomycetes
Wang Q, Xie F, Tong Y, Habisch R, Yang B, Zhang L, Müller R, Fu C (2020)
Applied Microbiology and Biotechnology, 104 (1): 225-239DOI: 10.1007/s00253-019-10223-4
Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model
Park Y, Meyer M, Müller R, Herrmann J (2020)
Molecules, 25 (19)DOI: 10.3390/molecules25194474
2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene-Nucleoside
Okoth D, Hug J, Garcia R, Spröer C, Overmann J, Müller R (2020)
Molecules (Basel, Switzerland), 25 (11)DOI: 10.3390/molecules25112676
Biosynthesis of Cittilins, Unusual Ribosomally Synthesized and Post-translationally Modified Peptides from Myxococcus xanthus
Hug J, Dastbaz J, Adam S, Revermann O, Koehnke J, Krug D, Müller R (2020)
ACS chemical biology, 15 (8): 2221-2231DOI: 10.1021/acschembio.0c00430
7-Hydroxycoumarins are Affinity-based Fluorescent Probes for Competitive Binding Studies of Macrophage Migration Inhibitory Factor
Xiao Z, Chen D, Song S, van der Vlag R, van der Wouden P, van Merkerk R, Cool R, Hirsch A, Melgert B, Quax W, Poelarends G, Dekker F (2020)
Journal of medicinal chemistryDOI: 10.1021/acs.jmedchem.0c01160
Advancing human in vitro pulmonary disease models in preclinical research: opportunities for lung-on-chips
Artzy-Schnirman A, Lehr C, Sznitman J (2020)
Expert Opinion on Drug Delivery, 17 (5): 621-625DOI: 10.1080/17425247.2020.1738380
Design and in vitro characterization of multistage silicon-PLGA budesonide particles for inflammatory bowel disease
Leonard F, Srinivasan S, Liu X, Collnot E, Ferrari M, Lehr C, Godin B (2020)
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 151: 61-72DOI: 10.1016/j.ejpb.2020.03.020
pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers
Lee S, Kaya C, Jang H, Koch M, Loretz B, Buhler E, Lehr C, Hirsch A (2020)
Mater. Chem. Front., 4 (3): 905-909DOI: 10.1039/C9QM00651F
Nanoparticle Targeting to Scalp Hair Follicles: New Perspectives for a Topical Therapy for Alopecia Areata
Christmann R, Thomas C, Jager N, Raber A, Loretz B, Schaefer U, Tschernig T, Vogt T, Lehr C (2020)
The Journal of investigative dermatology, 140 (1): 243-246DOI: 10.1016/j.jid.2019.05.028
P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives
Montefusco-Pereira C, Horstmann J, Ebensen T, Beisswenger C, Bals R, Guzmán C, Schneider-Daum N, Carvalho-Wodarz C, Lehr C (2020)
Journal of visualized experiments : JoVE (160)DOI: 10.3791/61069
Safety assessment of excipients (SAFE) for orally inhaled drug products
Metz J, Scharnowske L, Hans F, Schnur S, Knoth K, Zimmer H, Limberger M, Groß H, Lehr C, Hittinger M (2020)
ALTEX, 37 (2): 275-286DOI: 10.14573/altex.1910231
Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections
Ho D, Murgia X, Rossi C, Christmann R, Hüfner de Mello Martins A, Koch M, Andreas A, Herrmann J, Müller R, Empting M, …, Couvreur P, Lehr C (2020)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202001407
Itaconic Acid Increases the Efficacy of Tobramycin against Pseudomonas aeruginosa Biofilms
Ho D, Rossi C, Loretz B, Murgia X, Lehr C (2020)
Pharmaceutics, 12 (8)DOI: 10.3390/pharmaceutics12080691
3D air-liquid interface culture of Cystic Fibrosis bronchial epithelia, macrophages and P. aeruginosa to assess host-pathogen interaction and drug efficacy
Montefusco C, Montefusco-Pereira C (2020)
BookDOI: 10.22028/D291-31815
Inhalationstoxizität von Nanopartikeln // The role of alveolar macrophages in biokinetics and biological effects of inhaled nanoparticles
Koltermann-Jülly J (2020)
BookDOI: 10.22028/D291-31034
Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach
Markella Konstantinidou, Francesca Magari, Fandi Sutanto, Jörg Haupenthal, Varsha R. Jumde, M. Yagiz Ünver, Andreas Heine, Carlos Jamie Camacho, Anna K. H. Hirsch, Gerhard Klebe, Alexander Dömling (2020)
ChemMedChem, 15 (8): 680-684DOI: 10.1002/cmdc.202000024
Optimized Inhibitors of MDM2 via an Attempted Protein‐Templated Reductive Amination
Vlag R, Yagiz Unver M, Felicetti T, Twarda-Clapa A, Kassim F, Ermis C, Neochoritis C, Musielak B, Labuzek B, Dömling A, Holak T, Hirsch A (2020)
ChemMedChem, 15 (4): 370-375DOI: 10.1002/cmdc.201900574
Validating the 1,2-Difluoro Motif As a Hybrid Bioisostere of CF3 and Et Using Matrix Metalloproteinases As Structural Probes
Erdeljac N, Thiehoff C, Jumde R, Daniliuc C, Höppner S, Faust A, Hirsch A, Gilmour R (2020)
Journal of medicinal chemistry, 63 (11): 6225-6237DOI: 10.1021/acs.jmedchem.0c00648
Protein‐Templated Hit Identification via an Ugi Four‐Component Reaction
Mancini F, Unver M, Elgaher W, Jumde V, Alhayek A, Lukat P, Herrmann J, Witte M, Köck M, Blankenfeldt W, Müller R, Hirsch A (2020)
Chem. Eur. J.DOI: 10.1002/chem.202002250
N -Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases
Konstantinovic J, Yahiaoui S, Alhayek A, Haupenthal J, Schönauer E, Andreas A, Kany A, Müller R, Koehnke J, Berger F, …, Brandstetter H, Hirsch A (2020)
J. Med. Chem., 63 (15): 8359-8368DOI: 10.1021/acs.jmedchem.0c00584
Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement
Zielinska A, Savietto A, Sousa Borges A, Martinez D, Berbon M, Roelofsen J, Hartman A, Boer R, van der Klei I, Hirsch A, …, Bramkamp M, Scheffers D (2020)
eLife, 9DOI: 10.7554/eLife.57179
Potential Dental Biofilm Inhibitors: Dynamic Combinatorial Chemistry Affords Sugar-Based Molecules that Target Bacterial Glucosyltransferase
Hartman A, Jumde V, Elgaher W, Te Poele E, Dijkhuizen L, Hirsch A (2020)
ChemMedChemDOI: 10.1002/cmdc.202000222
A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d -galactose pentaacetate
Zahorska E, Kuhaudomlarp S, Minervini S, Yousaf S, Lepsik M, Kinsinger T, Hirsch A, Imberty A, Titz A (2020)
Chem. Commun., 56 (62): 8822-8825DOI: 10.1039/d0cc03490h
Enhancing Glycan Stability via Site-Selective Fluorination: Modulating Substrate Orientation by Molecular Design
Axer A, Jumde R, Adam S, Faust A, Schäfers M, Fobker M, Koehnke J, Hirsch A, Gilmour R (2020)
BookDOI: 10.26434/chemrxiv.12656210
Hit-Optimization Using Target-Directed Dynamic Combinatorial Chemistry: Development of Inhibitors of the Anti-Infective Target 1-Deoxy-D-Xylulose-5-Phosphate Synthase
Jumde R, Guardigni M, Gierse R, Alhayek A, Zhu D, Hamed Z, Johannsen S, Elgaher W, Haupenthal J, Hirsch A (2020)
BookDOI: 10.26434/chemrxiv.12681761.v1
SphereCon-a method for precise estimation of residue relative solvent accessible area from limited structural information
Gress A, Kalinina O (2020)
Bioinformatics (Oxford, England), 36 (11): 3372-3378DOI: 10.1093/bioinformatics/btaa159
Resistance-associated substitutions in patients with chronic hepatitis C virus genotype 4 infection
Dietz J, Kalinina O, Vermehren J, Peiffer K, Matschenz K, Buggisch P, Niederau C, Schattenberg J, Müllhaupt B, Yerly S, …, Welsch C, Sarrazin C (2020)
J. Viral Hepat.DOI: 10.1111/jvh.13322.
Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors
Bastys T, Gapsys V, Walter H, Heger E, Doncheva N, Kaiser R, Groot B, Kalinina O (2020)
Retrovirology, 17 (1)DOI: 10.1186/s12977-020-00520-6
A shift of dynamic equilibrium between the KIT active and inactive states causes drug resistance
Srikakulam S, Bastys T, Kalinina O (2020)
ProteinsDOI: 10.1002/prot.25963
Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy
Testolin G, Cirnski K, Rox K, Prochnow H, Fetz V, Grandclaudon C, Mollner T, Baiyoumy A, Ritter A, Leitner C, …, Müller R, Brönstrup M (2020)
Chemical Science, 11 (5): 1316-1334DOI: 10.1039/C9SC04769G
Restriction-Free Construction of a Phage-Presented Very Short Macrocyclic Peptide Library
Jakob V, Helmsing S, Hust M, Empting M (2020)
Methods in molecular biology (Clifton, N.J.), 2070: 95-113DOI: 10.1007/978-1-4939-9853-1_6
Discovery of Novel Latency-Associated Nuclear Antigen Inhibitors as Antiviral Agents Against Kaposi's Sarcoma-Associated Herpesvirus
Kirsch P, Jakob V, Elgaher W, Walt C, Oberhausen K, Schulz T, Empting M (2020)
ACS chemical biology, 15 (2): 388-395DOI: 10.1021/acschembio.9b00845
Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling
Hollenhorst M, Jurastow I, Nandigama R, Appenzeller S, Li L, Vogel J, Wiederhold S, Althaus M, Empting M, Altmüller J, …, Saliba A, Krasteva-Christ G (2020)
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34 (1): 316-332DOI: 10.1096/fj.201901314RR
BOPC1 Enantiomers Preparation and HuR Interaction Study. From Molecular Modeling to a Curious DEEP-STD NMR Application
Della Volpe S, Listro R, Parafioriti M, Di Giacomo M, Rossi D, Ambrosio F, Costa G, Alcaro S, Ortuso F, Hirsch A, Vasile F, Collina S (2020)
ACS Med. Chem. Lett., 11 (5): 883-888DOI: 10.1021/acsmedchemlett.9b00659
Synthesis and Biological Evaluation of Novel 2-Substituted Analogues of (–)-Pentenomycin I
Zisopoulou S, Bousis S, Haupenthal J, Herrmann J, Müller R, Hirsch A, Komiotis D, Gallos J, Stathakis C (2020)
Synlett, 31 (05): 475-481DOI: 10.1055/s-0039-1690772
Liver-derived extracellular vesicles: A cell by cell overview to isolation and characterization practices
Zivko C, Fuhrmann G, Luciani P (2020)
Biochimica et Biophysica Acta - General SubjectsDOI: 10.1016/j.bbagen.2020.129559
Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility
Montefusco-Pereira C, Formicola B, Goes A, Re F, Marrano C, Mantegazza F, Carvalho-Wodarz C, Fuhrmann G, Caneva E, Nicotra F, Lehr C, Russo L (2020)
European Journal of Pharmaceutics and Biopharmaceutics, 149: 12-20DOI: 10.1016/j.ejpb.2020.01.013
Diffusion and transport of extracellular vesicles
Fuhrmann G (2020)
Nature Nanotechnology, 15 (3): 168-169DOI: 10.1038/s41565-020-0651-3
Expression, Purification, and Functional Characterization of Tectonin 2 from Laccaria bicolor: A Six-Bladed Beta-Propeller Lectin Specific for O-Methylated Glycans
Wohlschlager T, Titz A, Künzler M, Varrot A (2020)
Methods Mol Biol, 2132: 669-682DOI: 10.1007/978-1-0716-0430-4_58
Bacteria as genetically programmable producers of bioactive natural products
Hug J, Krug D, Müller R (2020)
Nat. rev. chem., 4 (4): 172-193DOI: 10.1038/s41570-020-0176-1
Host Development for Heterologous Expression and Biosynthetic Studies of Myxobacterial Natural Products
Hug J, Müller R (2020)
, In pressDOI: 10.1016/B978-0-12-409547-2.14818-8
Myxobakterielle Naturstofffabriken
Krug D, Garcia R, Müller R (2020)
Biospektrum, 26 (1): 32-36DOI: 10.1007/s12268-020-1334-1
In depth natural product discovery - Myxobacterial strains that provided multiple secondary metabolites
Bader C, Panter F, Müller R (2020)
Biotechnol Adv., 39DOI: 10.1016/j.biotechadv.2019.107480
2019
Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier
Costa A, Souza Carvalho-Wodarz C, Seabra V, Sarmento B, Lehr C (2019)
Acta BiomaterialiaDOI: 10.1016/j.actbio.2019.04.037
Energy-Coupling Factor Transporters as Novel Antimicrobial Targets
Bousis S, Setyawati I, Diamanti E, slotboom d, Hirsch A (2019)
Adv. Therap., 2 (2)DOI: 10.1002/adtp.201800066
Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies
Della Volpe S, Nasti R, Queirolo M, Unver M, Jumde V, Dömling A, Vasile F, Potenza D, Ambrosio F, Costa G, …, Hirsch A, Collina S (2019)
ACS Med. Chem. Lett., 10 (4): 615-620DOI: 10.1021/acsmedchemlett.8b00600
From Wood to Tetrahydro-2-benzazepines in Three Waste-Free Steps: Modular Synthesis of Biologically Active Lignin-Derived Scaffolds
Elangovan S, Afanasenko A, Haupenthal J, Sun Z, Liu Y, Hirsch A, Barta K (2019)
ACS Cent. Sci., 5 (10): 1707-1716DOI: 10.1021/acscentsci.9b00781
Production optimization and biosynthesis revision of corallopyronin A, a potent anti-filarial antibiotic
Pogorevc D, Panter F, Schillinger C, Jansen R, Wenzel S, Müller R (2019)
Metab. Eng., 55: 201-211DOI: 10.1016/j.ymben.2019.07.010
Engineering Atypical Tetracycline Formation in Amycolatopsis sulphurea for the Production of Modified Chelocardin Antibiotics
Lukežic T, Fayad A, Bader C, Harmrolfs K, Bartuli J, Groß S, Lešnik U, Hennessen F, Herrmann J, Pikl Š, Petkovic H, Müller R (2019)
ACS Chem. Biol., 14 (3): 468-477DOI: 10.1021/acschembio.8b01125
Challenges and Strategies in Drug Delivery Systems for Treatment of Pulmonary Infections
Ho D, Nichols B, Edgar K, Murgia X, Loretz B, Lehr C (2019)
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.VDOI: 10.1016/j.ejpb.2019.09.002
Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline
Artzy-Schnirman A, Hobi N, Schneider-Daum N, Guenat O, Lehr C, Sznitman J (2019)
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 144: 11-17DOI: 10.1016/j.ejpb.2019.09.006
Macro- and Microrheological Properties of Mucus Surrogates in Comparison to Native Intestinal and Pulmonary Mucus
Huck B, Hartwig O, Biehl A, Schwarzkopf K, Wagner C, Loretz B, Murgia X, Lehr C (2019)
Biomacromolecules, 20 (9): 3504-3512DOI: 10.1021/acs.biomac.9b00780
Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration
Thanki K, van Eetvelde D, Geyer A, Fraire J, Hendrix R, van Eygen H, Putteman E, Sami H, Souza Carvalho-Wodarz C, Franzyk H, …, Ogris M, Foged C (2019)
Journal of controlled release : official journal of the Controlled Release Society, 310: 82-93DOI: 10.1016/j.jconrel.2019.08.004
Bioinspired Liposomes for Oral Delivery of Colistin to Combat Intracellular Infections by Salmonella enterica
Menina S, Eisenbeis J, Kamal M, Koch M, Bischoff M, Gordon S, Loretz B, Lehr C (2019)
Advanced healthcare materials, 8 (17)DOI: 10.1002/adhm.201900564
Preferential uptake of chitosan-coated PLGA nanoparticles by primary human antigen presenting cells
Durán V, Yasar H, Becker J, Thiyagarajan D, Loretz B, Kalinke U, Lehr C (2019)
Nanomedicine : nanotechnology, biology, and medicine, 21DOI: 10.1016/j.nano.2019.102073
The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
Formicola B, Dal Magro R, Montefusco-Pereira C, Lehr C, Koch M, Russo L, Grasso G, Deriu M, Danani A, Bourdoulous S, Re F (2019)
Journal of nanobiotechnology, 17 (1)DOI: 10.1186/s12951-019-0546-3
Capturing the Onset of Bacterial Pulmonary Infection in Acini‐On‐Chips
Artzy-Schnirman A, Zidan H, Elias-Kirma S, Ben-Porat L, Tenenbaum-Katan J, Carius P, Fishler R, Schneider-Daum N, Lehr C, Sznitman J (2019)
Adv. Biosys., 3 (9)DOI: 10.1002/adbi.201900026
OCTN2-Mediated Acetyl-l-Carnitine Transport in Human Pulmonary Epithelial Cells In Vitro
Salomon J, Gausterer J, Selo M, Hosoya K, Huwer H, Schneider-Daum N, Lehr C, Ehrhardt C (2019)
Pharmaceutics, 11 (8)DOI: 10.3390/pharmaceutics11080396
Preparation, characterization and in vitro antibacterial property of Ciprofloxacin-loaded nanostructured lipid carrier for treatment of Bacillus subtilis infection
Nnamani P, Ugwu A, Ibezim E, Onoja S, Odo A, Windbergs M, Rossi C, Lehr C, Attama A (2019)
Journal of Microencapsulation: 1-30DOI: 10.1080/02652048.2019.1582724
Pseudobacterial nanocarriers for intracellular delivery of anti-infectives
Castoldi A (2019)
UnpublishedWorkDOI: 10.22028/D291-27989
Interaction of nanoparticles with the pulmonary barrier; The role of mucus in health and disease // The Role of Airway Mucus as a Barrier to Nanoparticles: Implications for Pulmonary Drug Delivery
Murgia X, Murgia Esteve X (2019)
BookDOI: 10.22028/D291-31240
Non-invasive vaccination by nanoparticle-based messenger RNA (mRNA) delivery via the transfollicular route
Yasar H (2019)
UnpublishedWorkDOI: 10.22028/D291-27933
Comparing the Self-Assembly of Sexiphenyl-Dicarbonitrile on Graphite and Graphene on Cu(111)
Schmidt N, Li J, Gottardi S, Moreno-Lopez J, Enache M, Monjas L, van der Vlag R, Havenith R, Hirsch A, Stöhr M (2019)
Chem. Eur. J., 25 (19): 5065-5070DOI: 10.1002/chem.201806312
Inverting Small Molecule–Protein Recognition by the Fluorine Gauche Effect: Selectivity Regulated by Multiple H→F Bioisosterism
Bentler P, Bergander K, Daniliuc C, Mück-Lichtenfeld C, Jumde R, Hirsch A, Gilmour R (2019)
Angewandte Chemie (International ed. in English), 58 (32): 10990-10994DOI: 10.1002/anie.201905452
Spray-drying of inhalable, multifunctional formulations for the treatment of biofilms formed in cystic fibrosis
Lababidi N, Ofosu Kissi E, Elgaher W, Sigal V, Haupenthal J, Schwarz B, Hirsch A, Rades T, Schneider M (2019)
Journal of Controlled Release, 314: 62-71DOI: 10.1016/j.jconrel.2019.10.038
Adenosine-to-Inosine RNA Editing in Mouse and Human Brain Proteomes
Levitsky L, Kliuchnikova A, Kuznetsova K, Karpov D, Ivanov M, Pyatnitskiy M, Kalinina O, Gorshkov M, Moshkovskii S (2019)
Proteomics, 19 (23)DOI: 10.1002/pmic.201900195.
Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy
Pfitzer L, Moser C, Gegenfurtner F, Arner A, Foerster F, Atzberger C, Zisis T, Kubisch-Dohmen R, Busse J, Smith R, …, Vollmar A, Zahler S (2019)
Cell Death Dis., 10 (4)DOI: 10.1038/s41419-019-1546-9
Synthesis of New Cyclomarin Derivatives and Their Biological Evaluation towards Mycobacterium Tuberculosis and Plasmodium Falciparum
Kiefer A, Bader C, Held J, Esser A, Rybniker J, Empting M, Müller R, Kazmaier U (2019)
Chem. Eur. J., 25 (37): 8894-8902DOI: 10.1002/chem.201901640
Fragment-Based Discovery of a Qualified Hit Targeting the Latency-Associated Nuclear Antigen of the Oncogenic Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8
Kirsch P, Jakob V, Oberhausen K, Stein S, Cucarro I, Schulz T, Empting M (2019)
Journal of medicinal chemistry, 62 (8): 3924-3939DOI: 10.1021/acs.jmedchem.8b01827
Hit evaluation of an α-helical peptide: Ala-scan, truncation and sidechain-to-sidechain macrocyclization of an RNA polymerase Inhibitor
Kamal A, Habib M, Haupenthal J, Hartmann R, Empting M (2019)
Biol. Chem., 400 (3): 333-342DOI: 10.1515/hsz-2018-0333
Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol
Hartman A, Gierse R, Hirsch A (2019)
Eur. J. Org. Chem., 2019 (22): 3581-3590DOI: 10.1002/ejoc.201900327
Concepts and Core Principles of Fragment-Based Drug Design
Kirsch P, Hartman A, Hirsch A, Empting M (2019)
Molecules (Basel, Switzerland), 24 (23)DOI: 10.3390/molecules24234309
A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1
van der Vlag R, Guo H, Hapko U, Eleftheriadis N, Monjas L, Dekker F, Hirsch A (2019)
European journal of medicinal chemistry, 174: 45-55DOI: 10.1016/j.ejmech.2019.04.021
Rational Adaptation of L3MBTL1 Inhibitors to Create Small-Molecule Cbx7 Antagonists
Simhadri C, Daze K, Douglas S, Milosevich N, Monjas L, Dev A, Brown T, Hirsch A, Wulff J, Hof F (2019)
ChemMedChem, 14 (15): 1444-1456DOI: 10.1002/cmdc.201900021
Low-Dimensional Metal-Organic Coordination Structures on Graphene
Li J, Solianyk L, Schmidt N, Baker B, Gottardi S, Moreno Lopez J, Enache M, Monjas L, van der Vlag R, Havenith R, Hirsch A, Stöhr M (2019)
The journal of physical chemistry. C, Nanomaterials and interfaces, 123 (20): 12730-12735DOI: 10.1021/acs.jpcc.9b00326
Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity
Guo H, Verhoek I, Prins G, van der Vlag R, van der Wouden P, van Merkerk R, Quax W, Olinga P, Hirsch A, Dekker F (2019)
Journal of medicinal chemistry, 62 (9): 4624-4637DOI: 10.1021/acs.jmedchem.9b00212
Replacement of an Indole Scaffold Targeting Human 15-Lipoxygenase-1 Using Combinatorial Chemistry
Prismawan D, van der Vlag R, Guo H, Dekker F, Hirsch A (2019)
HCA, 102 (5)DOI: 10.1002/hlca.201900040
Reversible immobilization of a protein to a gold surface through multiple host-guest interactions
Schwarz D, Elgaher W, Hollemeyer K, Hirsch A, Wenz G (2019)
J. Mater. Chem. B, 7 (40): 6148-6155DOI: 10.1039/c9tb00560a
Surface state tunable energy and mass renormalization from homothetic quantum dot arrays
Piquero-Zulaica I, Li J, Abd El-Fattah Z, Solianyk L, Gallardo I, Monjas L, Hirsch A, Arnau A, Ortega J, Stöhr M, Lobo-Checa J (2019)
Nanoscale, 11 (48): 23132-23138DOI: 10.1039/C9NR07365E
Corrigendum to biocompatible bacteria-derived vesicles show inherent antimicrobial activity (Journal of Controlled Release (2018) 290 (46–55), (S0168365918305698) (10.1016/j.jconrel.2018.09.030))
Schulz E, Goes A, Garcia R, Panter F, Koch M, Müller R, Fuhrmann K, Fuhrmann G (2019)
Journal of Controlled Release, 293: 155-157DOI: 10.1016/j.jconrel.2018.11.027
Author Correction: Extracellular vesicles protect glucuronidase model enzymes during freeze-drying (Scientific Reports, (2018), 8, 1, (12377), 10.1038/s41598-018-30786-y)
Frank J, Richter M, Rossi C, Lehr C, Fuhrmann K, Fuhrmann G (2019)
Scientific Reports, 9 (1)DOI: 10.1038/s41598-019-48221-1
Engineering strategies for oral therapeutic enzymes to enhance their stability and activity
Lapuhs P, Fuhrmann G (2019)
Book, 1148DOI: 10.1007/978-981-13-7709-9_8
Toll-Like Receptor 2 Release by Macrophages: An Anti-inflammatory Program Induced by Glucocorticoids and Lipopolysaccharide
Hoppstädter J, Dembek A, Linnenberger R, Dahlem C, Barghash A, Fecher-Trost C, Fuhrmann G, Koch M, Kraegeloh A, Huwer H, Kiemer A (2019)
Front. Immunol., 10DOI: 10.3389/fimmu.2019.01634
Induction of rare conformation of oligosaccharide by binding to calcium-dependent bacterial lectin: X-ray crystallography and modelling study
Lepsik M, Sommer R, Kuhaudomlarp S, Lelimousin M, Paci E, Varrot A, Titz A, Imberty A (2019)
European journal of medicinal chemistry, 177: 212-220DOI: 10.1016/j.ejmech.2019.05.049
Chemical synthesis of tripeptide thioesters for the biotechnological incorporation into the myxobacterial secondary metabolite argyrin via mutasynthesis
Siebert D, Sommer R, Pogorevc D, Hoffmann M, Wenzel S, Müller R, Titz A (2019)
Beilstein journal of organic chemistry, 15: 2922-2929DOI: 10.3762/bjoc.15.286
Anti-biofilm Agents against Pseudomonas aeruginosa: A Structure-Activity Relationship Study of C-Glycosidic LecB Inhibitors
Sommer R, Rox K, Wagner S, Hauck D, Henrikus S, Newsad S, Arnold T, Ryckmans T, Brönstrup M, Imberty A, …, Hartmann R, Titz A (2019)
Journal of medicinal chemistry, 62 (20): 9201-9216DOI: 10.1021/acs.jmedchem.9b01120
Lectin antagonists in infection, immunity, and inflammation
Meiers J, Siebs E, Zahorska E, Titz A (2019)
Current opinion in chemical biology, 53: 51-67DOI: 10.1016/j.cbpa.2019.07.005
Hot EVs – how temperature affects extracellular vesicles
Schulz E, Karagianni A, Koch M, Fuhrmann G (2019)
European Journal of Pharmaceutics and BiopharmaceuticsDOI: 10.1016/j.ejpb.2019.11.010
Extracellular Vesicles—Connecting Kingdoms
Woith E, Fuhrmann G, Melzig M (2019)
International journal of molecular sciences, 20 (22)DOI: 10.3390/ijms20225695
Clinical Resistome Screening of 1,110 Escherichia coli Isolates Efficiently Recovers Diagnostically Relevant Antibiotic Resistance Biomarkers and Potential Novel Resistance Mechanisms
Volz C, Ramoni J, Beisken S, Galata V, Keller A, Plum A, Posch A, Müller R (2019)
Front. Microbiol., 10DOI: 10.3389/fmicb.2019.01671
Polyunsaturated fatty acid production by Yarrowia lipolytica employing designed myxobacterial PUFA synthases
Gemperlein K, Dietrich D, Kohlstedt M, Zipf G, Bernauer H, Wittmann C, Wenzel S, Müller R (2019)
Nat. Commun., 10 (1)DOI: 10.1038/s41467-019-12025-8
Production of a Dibrominated Aromatic Secondary Metabolite by a Planctomycete Implies Complex Interaction with a Macroalgal Host
Panter F, Garcia R, Thewes A, Zaburannyi N, Bunk B, Overmann J, Gutierrez M, Krug D, Müller R (2019)
ACS Chem. Biol., 14 (accepted // 12): 2713-2719DOI: 10.1021/acschembio.9b00641
Evaluation of the Storage Stability of Extracellular Vesicles
Richter M, Fuhrmann K, Fuhrmann G (2019)
Journal of visualized experiments : JoVE (147)DOI: 10.3791/59584
Two Biosynthetic Pathways in Jahnella thaxteri for Thaxteramides, Distinct Types of Lipopeptides
Oueis E, Klefisch T, Zaburannyi N, Garcia R, Plaza A, Müller R (2019)
Org. Lett., 21 (14): 5407-5412DOI: 10.1021/acs.orglett.9b01524
The role of protein–protein interactions in the biosynthesis of ribosomally synthesized and post-translationally modified peptides
Sikandar A, Koehnke J (2019)
Nat. Prod. Rep.DOI: 10.1039/C8NP00064F
Dedication: Heinz Floss and Christopher Walsh-pioneers in natural product chemical biology
Müller R, Wright G (2019)
Journal of Industrial Microbiology & BiotechnologyDOI: 10.1007/s10295-019-02139-9
Armeniaspirol Antibiotic Biosynthesis: Chlorination and Oxidative Dechlorination Steps Affording Spiro4.4non-8-ene
Fu C, Xie F, Hoffmann J, Wang Q, Bauer A, Brönstrup M, Mahmud T, Müller R (2019)
ChemBioChem, 20 (6): 764-769DOI: 10.1002/cbic.201800791
Heterologous expression of bacterial natural product biosynthetic pathways
Huo L, Hug J, Fu C, Bian X, Zhang Y, Müller R (2019)
Nat. Prod. Rep., 36: 1412-1436DOI: 10.1039/C8NP00091C
Genome mining reveals uncommon alkylpyrones as type III PKS products from myxobacteria
Hug J, Panter F, Krug D, Müller R (2019)
J. Ind. Microbiol. Biotechnol., 46 (3-4): 319-334DOI: 10.1007/s10295-018-2105-6
Class I Methyltransferase VioH Catalyzes Unusual S-Adenosyl-l-methionine Cyclization Leading to 4-Methylazetidinecarboxylic Acid Formation during Vioprolide Biosynthesis
Yan F, Müller R (2019)
ACS Chem. Biol., 14 (1): 99-105DOI: 10.1021/acschembio.8b00958
Novel Methoxymethacrylate Natural Products Uncovered by Statistics-Based Mining of the Myxococcus fulvus Secondary Metabolome
Panter F, Krug D, Müller R (2019)
ACS Chem. Biol., 14 (1): 88-98DOI: 10.1021/acschembio.8b00948