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PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus

Anversa Dimer F, Souza Carvalho-Wodarz C, Goes A, Cirnski K, Herrmann J, Schmitt V, Pätzold L, Abed N, Rossi C, Bischoff M, …, Müller R, Lehr C (2020)

Nanomedicine : nanotechnology, biology, and medicine, 24DOI: 10.1016/j.nano.2019.102125

Probiomimetics-Novel Lactobacillus-Mimicking Microparticles Show Anti-Inflammatory and Barrier-Protecting Effects in Gastrointestinal Models

Kuhn T, Koch M, Fuhrmann G (2020)

Small (Weinheim an der Bergstrasse, Germany)DOI: 10.1002/smll.202003158

Discovery of Antibacterial Agents Inhibiting the Energy-Coupling Factor (ECF) Transporters by Structure-Based Virtual Screening

Diamanti E, Setyawati I, Bousis S, mojas l, Swier l, Haupenthal J, Gibson P, Volz C, stanek w, Jaeger m, …, slotboom d, Hirsch A (2020)

BookDOI: 10.26434/chemrxiv.11728710.v1

Streptococcal Extracellular Membrane Vesicles Are Rapidly Internalized by Immune Cells and Alter Their Cytokine Release

Mehanny M, Koch M, Lehr C, Fuhrmann G (2020)

Frontiers in immunology, 11DOI: 10.3389/fimmu.2020.00080

Dual-function chromogenic screening-based CRISPR/Cas9 genome editing system for actinomycetes

Wang Q, Xie F, Tong Y, Habisch R, Yang B, Zhang L, Müller R, Fu C (2020)

Applied Microbiology and Biotechnology, 104 (1): 225-239DOI: 10.1007/s00253-019-10223-4

Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model

Park Y, Meyer M, Müller R, Herrmann J (2020)

Molecules, 25 (19)DOI: 10.3390/molecules25194474

2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene-Nucleoside

Okoth D, Hug J, Garcia R, Spröer C, Overmann J, Müller R (2020)

Molecules (Basel, Switzerland), 25 (11)DOI: 10.3390/molecules25112676

Biosynthesis of Cittilins, Unusual Ribosomally Synthesized and Post-translationally Modified Peptides from Myxococcus xanthus

Hug J, Dastbaz J, Adam S, Revermann O, Koehnke J, Krug D, Müller R (2020)

ACS chemical biology, 15 (8): 2221-2231DOI: 10.1021/acschembio.0c00430

7-Hydroxycoumarins are Affinity-based Fluorescent Probes for Competitive Binding Studies of Macrophage Migration Inhibitory Factor

Xiao Z, Chen D, Song S, van der Vlag R, van der Wouden P, van Merkerk R, Cool R, Hirsch A, Melgert B, Quax W, Poelarends G, Dekker F (2020)

Journal of medicinal chemistryDOI: 10.1021/acs.jmedchem.0c01160

Advancing human in vitro pulmonary disease models in preclinical research: opportunities for lung-on-chips

Artzy-Schnirman A, Lehr C, Sznitman J (2020)

Expert Opinion on Drug Delivery, 17 (5): 621-625DOI: 10.1080/17425247.2020.1738380

Design and in vitro characterization of multistage silicon-PLGA budesonide particles for inflammatory bowel disease

Leonard F, Srinivasan S, Liu X, Collnot E, Ferrari M, Lehr C, Godin B (2020)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 151: 61-72DOI: 10.1016/j.ejpb.2020.03.020

pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers

Lee S, Kaya C, Jang H, Koch M, Loretz B, Buhler E, Lehr C, Hirsch A (2020)

Mater. Chem. Front., 4 (3): 905-909DOI: 10.1039/C9QM00651F

Nanoparticle Targeting to Scalp Hair Follicles: New Perspectives for a Topical Therapy for Alopecia Areata

Christmann R, Thomas C, Jager N, Raber A, Loretz B, Schaefer U, Tschernig T, Vogt T, Lehr C (2020)

The Journal of investigative dermatology, 140 (1): 243-246DOI: 10.1016/j.jid.2019.05.028

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives

Montefusco-Pereira C, Horstmann J, Ebensen T, Beisswenger C, Bals R, Guzmán C, Schneider-Daum N, Carvalho-Wodarz C, Lehr C (2020)

Journal of visualized experiments : JoVE (160)DOI: 10.3791/61069

Safety assessment of excipients (SAFE) for orally inhaled drug products

Metz J, Scharnowske L, Hans F, Schnur S, Knoth K, Zimmer H, Limberger M, Groß H, Lehr C, Hittinger M (2020)

ALTEX, 37 (2): 275-286DOI: 10.14573/altex.1910231

Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections

Ho D, Murgia X, Rossi C, Christmann R, Hüfner de Mello Martins A, Koch M, Andreas A, Herrmann J, Müller R, Empting M, …, Couvreur P, Lehr C (2020)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202001407

Itaconic Acid Increases the Efficacy of Tobramycin against Pseudomonas aeruginosa Biofilms

Ho D, Rossi C, Loretz B, Murgia X, Lehr C (2020)

Pharmaceutics, 12 (8)DOI: 10.3390/pharmaceutics12080691

3D air-liquid interface culture of Cystic Fibrosis bronchial epithelia, macrophages and P. aeruginosa to assess host-pathogen interaction and drug efficacy

Montefusco C, Montefusco-Pereira C (2020)

BookDOI: 10.22028/D291-31815

Inhalationstoxizität von Nanopartikeln // The role of alveolar macrophages in biokinetics and biological effects of inhaled nanoparticles

Koltermann-Jülly J (2020)

BookDOI: 10.22028/D291-31034

Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach

Markella Konstantinidou, Francesca Magari, Fandi Sutanto, Jörg Haupenthal, Varsha R. Jumde, M. Yagiz Ünver, Andreas Heine, Carlos Jamie Camacho, Anna K. H. Hirsch, Gerhard Klebe, Alexander Dömling (2020)

ChemMedChem, 15 (8): 680-684DOI: 10.1002/cmdc.202000024

Optimized Inhibitors of MDM2 via an Attempted Protein‐Templated Reductive Amination

Vlag R, Yagiz Unver M, Felicetti T, Twarda-Clapa A, Kassim F, Ermis C, Neochoritis C, Musielak B, Labuzek B, Dömling A, Holak T, Hirsch A (2020)

ChemMedChem, 15 (4): 370-375DOI: 10.1002/cmdc.201900574

Validating the 1,2-Difluoro Motif As a Hybrid Bioisostere of CF3 and Et Using Matrix Metalloproteinases As Structural Probes

Erdeljac N, Thiehoff C, Jumde R, Daniliuc C, Höppner S, Faust A, Hirsch A, Gilmour R (2020)

Journal of medicinal chemistry, 63 (11): 6225-6237DOI: 10.1021/acs.jmedchem.0c00648

Protein‐Templated Hit Identification via an Ugi Four‐Component Reaction

Mancini F, Unver M, Elgaher W, Jumde V, Alhayek A, Lukat P, Herrmann J, Witte M, Köck M, Blankenfeldt W, Müller R, Hirsch A (2020)

Chem. Eur. J.DOI: 10.1002/chem.202002250

N -Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases

Konstantinovic J, Yahiaoui S, Alhayek A, Haupenthal J, Schönauer E, Andreas A, Kany A, Müller R, Koehnke J, Berger F, …, Brandstetter H, Hirsch A (2020)

J. Med. Chem., 63 (15): 8359-8368DOI: 10.1021/acs.jmedchem.0c00584

Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement

Zielinska A, Savietto A, Sousa Borges A, Martinez D, Berbon M, Roelofsen J, Hartman A, Boer R, van der Klei I, Hirsch A, …, Bramkamp M, Scheffers D (2020)

eLife, 9DOI: 10.7554/eLife.57179

Potential Dental Biofilm Inhibitors: Dynamic Combinatorial Chemistry Affords Sugar-Based Molecules that Target Bacterial Glucosyltransferase

Hartman A, Jumde V, Elgaher W, Te Poele E, Dijkhuizen L, Hirsch A (2020)

ChemMedChemDOI: 10.1002/cmdc.202000222

A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d -galactose pentaacetate

Zahorska E, Kuhaudomlarp S, Minervini S, Yousaf S, Lepsik M, Kinsinger T, Hirsch A, Imberty A, Titz A (2020)

Chem. Commun., 56 (62): 8822-8825DOI: 10.1039/d0cc03490h

Enhancing Glycan Stability via Site-Selective Fluorination: Modulating Substrate Orientation by Molecular Design

Axer A, Jumde R, Adam S, Faust A, Schäfers M, Fobker M, Koehnke J, Hirsch A, Gilmour R (2020)

BookDOI: 10.26434/chemrxiv.12656210

Hit-Optimization Using Target-Directed Dynamic Combinatorial Chemistry: Development of Inhibitors of the Anti-Infective Target 1-Deoxy-D-Xylulose-5-Phosphate Synthase

Jumde R, Guardigni M, Gierse R, Alhayek A, Zhu D, Hamed Z, Johannsen S, Elgaher W, Haupenthal J, Hirsch A (2020)

BookDOI: 10.26434/chemrxiv.12681761.v1

SphereCon-a method for precise estimation of residue relative solvent accessible area from limited structural information

Gress A, Kalinina O (2020)

Bioinformatics (Oxford, England), 36 (11): 3372-3378DOI: 10.1093/bioinformatics/btaa159

Resistance-associated substitutions in patients with chronic hepatitis C virus genotype 4 infection

Dietz J, Kalinina O, Vermehren J, Peiffer K, Matschenz K, Buggisch P, Niederau C, Schattenberg J, Müllhaupt B, Yerly S, …, Welsch C, Sarrazin C (2020)

J. Viral Hepat.DOI: 10.1111/jvh.13322.

Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors

Bastys T, Gapsys V, Walter H, Heger E, Doncheva N, Kaiser R, Groot B, Kalinina O (2020)

Retrovirology, 17 (1)DOI: 10.1186/s12977-020-00520-6

A shift of dynamic equilibrium between the KIT active and inactive states causes drug resistance

Srikakulam S, Bastys T, Kalinina O (2020)

ProteinsDOI: 10.1002/prot.25963

Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy

Testolin G, Cirnski K, Rox K, Prochnow H, Fetz V, Grandclaudon C, Mollner T, Baiyoumy A, Ritter A, Leitner C, …, Müller R, Brönstrup M (2020)

Chemical Science, 11 (5): 1316-1334DOI: 10.1039/C9SC04769G

Restriction-Free Construction of a Phage-Presented Very Short Macrocyclic Peptide Library

Jakob V, Helmsing S, Hust M, Empting M (2020)

Methods in molecular biology (Clifton, N.J.), 2070: 95-113DOI: 10.1007/978-1-4939-9853-1_6

Discovery of Novel Latency-Associated Nuclear Antigen Inhibitors as Antiviral Agents Against Kaposi's Sarcoma-Associated Herpesvirus

Kirsch P, Jakob V, Elgaher W, Walt C, Oberhausen K, Schulz T, Empting M (2020)

ACS chemical biology, 15 (2): 388-395DOI: 10.1021/acschembio.9b00845

Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling

Hollenhorst M, Jurastow I, Nandigama R, Appenzeller S, Li L, Vogel J, Wiederhold S, Althaus M, Empting M, Altmüller J, …, Saliba A, Krasteva-Christ G (2020)

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34 (1): 316-332DOI: 10.1096/fj.201901314RR

BOPC1 Enantiomers Preparation and HuR Interaction Study. From Molecular Modeling to a Curious DEEP-STD NMR Application

Della Volpe S, Listro R, Parafioriti M, Di Giacomo M, Rossi D, Ambrosio F, Costa G, Alcaro S, Ortuso F, Hirsch A, Vasile F, Collina S (2020)

ACS Med. Chem. Lett., 11 (5): 883-888DOI: 10.1021/acsmedchemlett.9b00659

Synthesis and Biological Evaluation of Novel 2-Substituted ­Analogues of (–)-Pentenomycin I

Zisopoulou S, Bousis S, Haupenthal J, Herrmann J, Müller R, Hirsch A, Komiotis D, Gallos J, Stathakis C (2020)

Synlett, 31 (05): 475-481DOI: 10.1055/s-0039-1690772

Liver-derived extracellular vesicles: A cell by cell overview to isolation and characterization practices

Zivko C, Fuhrmann G, Luciani P (2020)

Biochimica et Biophysica Acta - General SubjectsDOI: 10.1016/j.bbagen.2020.129559

Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility

Montefusco-Pereira C, Formicola B, Goes A, Re F, Marrano C, Mantegazza F, Carvalho-Wodarz C, Fuhrmann G, Caneva E, Nicotra F, Lehr C, Russo L (2020)

European Journal of Pharmaceutics and Biopharmaceutics, 149: 12-20DOI: 10.1016/j.ejpb.2020.01.013

Diffusion and transport of extracellular vesicles

Fuhrmann G (2020)

Nature Nanotechnology, 15 (3): 168-169DOI: 10.1038/s41565-020-0651-3

Expression, Purification, and Functional Characterization of Tectonin 2 from Laccaria bicolor: A Six-Bladed Beta-Propeller Lectin Specific for O-Methylated Glycans

Wohlschlager T, Titz A, Künzler M, Varrot A (2020)

Methods Mol Biol, 2132: 669-682DOI: 10.1007/978-1-0716-0430-4_58

Bacteria as genetically programmable producers of bioactive natural products

Hug J, Krug D, Müller R (2020)

Nat. rev. chem., 4 (4): 172-193DOI: 10.1038/s41570-020-0176-1

Host Development for Heterologous Expression and Biosynthetic Studies of Myxobacterial Natural Products

Hug J, Müller R (2020)

, In pressDOI: 10.1016/B978-0-12-409547-2.14818-8

Myxobakterielle Naturstofffabriken

Krug D, Garcia R, Müller R (2020)

Biospektrum, 26 (1): 32-36DOI: 10.1007/s12268-020-1334-1

In depth natural product discovery - Myxobacterial strains that provided multiple secondary metabolites

Bader C, Panter F, Müller R (2020)

Biotechnol Adv., 39DOI: 10.1016/j.biotechadv.2019.107480


Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier

Costa A, Souza Carvalho-Wodarz C, Seabra V, Sarmento B, Lehr C (2019)

Acta BiomaterialiaDOI: 10.1016/j.actbio.2019.04.037

Energy-Coupling Factor Transporters as Novel Antimicrobial Targets

Bousis S, Setyawati I, Diamanti E, slotboom d, Hirsch A (2019)

Adv. Therap., 2 (2)DOI: 10.1002/adtp.201800066

Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies

Della Volpe S, Nasti R, Queirolo M, Unver M, Jumde V, Dömling A, Vasile F, Potenza D, Ambrosio F, Costa G, …, Hirsch A, Collina S (2019)

ACS Med. Chem. Lett., 10 (4): 615-620DOI: 10.1021/acsmedchemlett.8b00600

From Wood to Tetrahydro-2-benzazepines in Three Waste-Free Steps: Modular Synthesis of Biologically Active Lignin-Derived Scaffolds

Elangovan S, Afanasenko A, Haupenthal J, Sun Z, Liu Y, Hirsch A, Barta K (2019)

ACS Cent. Sci., 5 (10): 1707-1716DOI: 10.1021/acscentsci.9b00781

Production optimization and biosynthesis revision of corallopyronin A, a potent anti-filarial antibiotic

Pogorevc D, Panter F, Schillinger C, Jansen R, Wenzel S, Müller R (2019)

Metab. Eng., 55: 201-211DOI: 10.1016/j.ymben.2019.07.010

Engineering Atypical Tetracycline Formation in Amycolatopsis sulphurea for the Production of Modified Chelocardin Antibiotics

Lukežic T, Fayad A, Bader C, Harmrolfs K, Bartuli J, Groß S, Lešnik U, Hennessen F, Herrmann J, Pikl Š, Petkovic H, Müller R (2019)

ACS Chem. Biol., 14 (3): 468-477DOI: 10.1021/acschembio.8b01125

Challenges and Strategies in Drug Delivery Systems for Treatment of Pulmonary Infections

Ho D, Nichols B, Edgar K, Murgia X, Loretz B, Lehr C (2019)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.VDOI: 10.1016/j.ejpb.2019.09.002

Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline

Artzy-Schnirman A, Hobi N, Schneider-Daum N, Guenat O, Lehr C, Sznitman J (2019)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 144: 11-17DOI: 10.1016/j.ejpb.2019.09.006

Macro- and Microrheological Properties of Mucus Surrogates in Comparison to Native Intestinal and Pulmonary Mucus

Huck B, Hartwig O, Biehl A, Schwarzkopf K, Wagner C, Loretz B, Murgia X, Lehr C (2019)

Biomacromolecules, 20 (9): 3504-3512DOI: 10.1021/acs.biomac.9b00780

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

Thanki K, van Eetvelde D, Geyer A, Fraire J, Hendrix R, van Eygen H, Putteman E, Sami H, Souza Carvalho-Wodarz C, Franzyk H, …, Ogris M, Foged C (2019)

Journal of controlled release : official journal of the Controlled Release Society, 310: 82-93DOI: 10.1016/j.jconrel.2019.08.004

Bioinspired Liposomes for Oral Delivery of Colistin to Combat Intracellular Infections by Salmonella enterica

Menina S, Eisenbeis J, Kamal M, Koch M, Bischoff M, Gordon S, Loretz B, Lehr C (2019)

Advanced healthcare materials, 8 (17)DOI: 10.1002/adhm.201900564

Preferential uptake of chitosan-coated PLGA nanoparticles by primary human antigen presenting cells

Durán V, Yasar H, Becker J, Thiyagarajan D, Loretz B, Kalinke U, Lehr C (2019)

Nanomedicine : nanotechnology, biology, and medicine, 21DOI: 10.1016/j.nano.2019.102073

The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

Formicola B, Dal Magro R, Montefusco-Pereira C, Lehr C, Koch M, Russo L, Grasso G, Deriu M, Danani A, Bourdoulous S, Re F (2019)

Journal of nanobiotechnology, 17 (1)DOI: 10.1186/s12951-019-0546-3

Capturing the Onset of Bacterial Pulmonary Infection in Acini‐On‐Chips

Artzy-Schnirman A, Zidan H, Elias-Kirma S, Ben-Porat L, Tenenbaum-Katan J, Carius P, Fishler R, Schneider-Daum N, Lehr C, Sznitman J (2019)

Adv. Biosys., 3 (9)DOI: 10.1002/adbi.201900026

OCTN2-Mediated Acetyl-l-Carnitine Transport in Human Pulmonary Epithelial Cells In Vitro

Salomon J, Gausterer J, Selo M, Hosoya K, Huwer H, Schneider-Daum N, Lehr C, Ehrhardt C (2019)

Pharmaceutics, 11 (8)DOI: 10.3390/pharmaceutics11080396

Preparation, characterization and in vitro antibacterial property of Ciprofloxacin-loaded nanostructured lipid carrier for treatment of Bacillus subtilis infection

Nnamani P, Ugwu A, Ibezim E, Onoja S, Odo A, Windbergs M, Rossi C, Lehr C, Attama A (2019)

Journal of Microencapsulation: 1-30DOI: 10.1080/02652048.2019.1582724

Pseudobacterial nanocarriers for intracellular delivery of anti-infectives

Castoldi A (2019)

UnpublishedWorkDOI: 10.22028/D291-27989

Interaction of nanoparticles with the pulmonary barrier; The role of mucus in health and disease // The Role of Airway Mucus as a Barrier to Nanoparticles: Implications for Pulmonary Drug Delivery

Murgia X, Murgia Esteve X (2019)

BookDOI: 10.22028/D291-31240

Non-invasive vaccination by nanoparticle-based messenger RNA (mRNA) delivery via the transfollicular route

Yasar H (2019)

UnpublishedWorkDOI: 10.22028/D291-27933

Comparing the Self-Assembly of Sexiphenyl-Dicarbonitrile on Graphite and Graphene on Cu(111)

Schmidt N, Li J, Gottardi S, Moreno-Lopez J, Enache M, Monjas L, van der Vlag R, Havenith R, Hirsch A, Stöhr M (2019)

Chem. Eur. J., 25 (19): 5065-5070DOI: 10.1002/chem.201806312

Inverting Small Molecule–Protein Recognition by the Fluorine Gauche Effect: Selectivity Regulated by Multiple H→F Bioisosterism

Bentler P, Bergander K, Daniliuc C, Mück-Lichtenfeld C, Jumde R, Hirsch A, Gilmour R (2019)

Angewandte Chemie (International ed. in English), 58 (32): 10990-10994DOI: 10.1002/anie.201905452

Spray-drying of inhalable, multifunctional formulations for the treatment of biofilms formed in cystic fibrosis

Lababidi N, Ofosu Kissi E, Elgaher W, Sigal V, Haupenthal J, Schwarz B, Hirsch A, Rades T, Schneider M (2019)

Journal of Controlled Release, 314: 62-71DOI: 10.1016/j.jconrel.2019.10.038

Adenosine-to-Inosine RNA Editing in Mouse and Human Brain Proteomes

Levitsky L, Kliuchnikova A, Kuznetsova K, Karpov D, Ivanov M, Pyatnitskiy M, Kalinina O, Gorshkov M, Moshkovskii S (2019)

Proteomics, 19 (23)DOI: 10.1002/pmic.201900195.

Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy

Pfitzer L, Moser C, Gegenfurtner F, Arner A, Foerster F, Atzberger C, Zisis T, Kubisch-Dohmen R, Busse J, Smith R, …, Vollmar A, Zahler S (2019)

Cell Death Dis., 10 (4)DOI: 10.1038/s41419-019-1546-9

Synthesis of New Cyclomarin Derivatives and Their Biological Evaluation towards Mycobacterium Tuberculosis and Plasmodium Falciparum

Kiefer A, Bader C, Held J, Esser A, Rybniker J, Empting M, Müller R, Kazmaier U (2019)

Chem. Eur. J., 25 (37): 8894-8902DOI: 10.1002/chem.201901640

Fragment-Based Discovery of a Qualified Hit Targeting the Latency-Associated Nuclear Antigen of the Oncogenic Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8

Kirsch P, Jakob V, Oberhausen K, Stein S, Cucarro I, Schulz T, Empting M (2019)

Journal of medicinal chemistry, 62 (8): 3924-3939DOI: 10.1021/acs.jmedchem.8b01827

Hit evaluation of an α-helical peptide: Ala-scan, truncation and sidechain-to-sidechain macrocyclization of an RNA polymerase Inhibitor

Kamal A, Habib M, Haupenthal J, Hartmann R, Empting M (2019)

Biol. Chem., 400 (3): 333-342DOI: 10.1515/hsz-2018-0333

Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol

Hartman A, Gierse R, Hirsch A (2019)

Eur. J. Org. Chem., 2019 (22): 3581-3590DOI: 10.1002/ejoc.201900327

Concepts and Core Principles of Fragment-Based Drug Design

Kirsch P, Hartman A, Hirsch A, Empting M (2019)

Molecules (Basel, Switzerland), 24 (23)DOI: 10.3390/molecules24234309

A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1

van der Vlag R, Guo H, Hapko U, Eleftheriadis N, Monjas L, Dekker F, Hirsch A (2019)

European journal of medicinal chemistry, 174: 45-55DOI: 10.1016/j.ejmech.2019.04.021

Rational Adaptation of L3MBTL1 Inhibitors to Create Small-Molecule Cbx7 Antagonists

Simhadri C, Daze K, Douglas S, Milosevich N, Monjas L, Dev A, Brown T, Hirsch A, Wulff J, Hof F (2019)

ChemMedChem, 14 (15): 1444-1456DOI: 10.1002/cmdc.201900021

Low-Dimensional Metal-Organic Coordination Structures on Graphene

Li J, Solianyk L, Schmidt N, Baker B, Gottardi S, Moreno Lopez J, Enache M, Monjas L, van der Vlag R, Havenith R, Hirsch A, Stöhr M (2019)

The journal of physical chemistry. C, Nanomaterials and interfaces, 123 (20): 12730-12735DOI: 10.1021/acs.jpcc.9b00326

Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity

Guo H, Verhoek I, Prins G, van der Vlag R, van der Wouden P, van Merkerk R, Quax W, Olinga P, Hirsch A, Dekker F (2019)

Journal of medicinal chemistry, 62 (9): 4624-4637DOI: 10.1021/acs.jmedchem.9b00212

Replacement of an Indole Scaffold Targeting Human 15-Lipoxygenase-1 Using Combinatorial Chemistry

Prismawan D, van der Vlag R, Guo H, Dekker F, Hirsch A (2019)

HCA, 102 (5)DOI: 10.1002/hlca.201900040

Reversible immobilization of a protein to a gold surface through multiple host-guest interactions

Schwarz D, Elgaher W, Hollemeyer K, Hirsch A, Wenz G (2019)

J. Mater. Chem. B, 7 (40): 6148-6155DOI: 10.1039/c9tb00560a

Surface state tunable energy and mass renormalization from homothetic quantum dot arrays

Piquero-Zulaica I, Li J, Abd El-Fattah Z, Solianyk L, Gallardo I, Monjas L, Hirsch A, Arnau A, Ortega J, Stöhr M, Lobo-Checa J (2019)

Nanoscale, 11 (48): 23132-23138DOI: 10.1039/C9NR07365E

Corrigendum to biocompatible bacteria-derived vesicles show inherent antimicrobial activity (Journal of Controlled Release (2018) 290 (46–55), (S0168365918305698) (10.1016/j.jconrel.2018.09.030))

Schulz E, Goes A, Garcia R, Panter F, Koch M, Müller R, Fuhrmann K, Fuhrmann G (2019)

Journal of Controlled Release, 293: 155-157DOI: 10.1016/j.jconrel.2018.11.027

Author Correction: Extracellular vesicles protect glucuronidase model enzymes during freeze-drying (Scientific Reports, (2018), 8, 1, (12377), 10.1038/s41598-018-30786-y)

Frank J, Richter M, Rossi C, Lehr C, Fuhrmann K, Fuhrmann G (2019)

Scientific Reports, 9 (1)DOI: 10.1038/s41598-019-48221-1

Engineering strategies for oral therapeutic enzymes to enhance their stability and activity

Lapuhs P, Fuhrmann G (2019)

Book, 1148DOI: 10.1007/978-981-13-7709-9_8

Toll-Like Receptor 2 Release by Macrophages: An Anti-inflammatory Program Induced by Glucocorticoids and Lipopolysaccharide

Hoppstädter J, Dembek A, Linnenberger R, Dahlem C, Barghash A, Fecher-Trost C, Fuhrmann G, Koch M, Kraegeloh A, Huwer H, Kiemer A (2019)

Front. Immunol., 10DOI: 10.3389/fimmu.2019.01634

Induction of rare conformation of oligosaccharide by binding to calcium-dependent bacterial lectin: X-ray crystallography and modelling study

Lepsik M, Sommer R, Kuhaudomlarp S, Lelimousin M, Paci E, Varrot A, Titz A, Imberty A (2019)

European journal of medicinal chemistry, 177: 212-220DOI: 10.1016/j.ejmech.2019.05.049

Chemical synthesis of tripeptide thioesters for the biotechnological incorporation into the myxobacterial secondary metabolite argyrin via mutasynthesis

Siebert D, Sommer R, Pogorevc D, Hoffmann M, Wenzel S, Müller R, Titz A (2019)

Beilstein journal of organic chemistry, 15: 2922-2929DOI: 10.3762/bjoc.15.286

Anti-biofilm Agents against Pseudomonas aeruginosa: A Structure-Activity Relationship Study of C-Glycosidic LecB Inhibitors

Sommer R, Rox K, Wagner S, Hauck D, Henrikus S, Newsad S, Arnold T, Ryckmans T, Brönstrup M, Imberty A, …, Hartmann R, Titz A (2019)

Journal of medicinal chemistry, 62 (20): 9201-9216DOI: 10.1021/acs.jmedchem.9b01120

Lectin antagonists in infection, immunity, and inflammation

Meiers J, Siebs E, Zahorska E, Titz A (2019)

Current opinion in chemical biology, 53: 51-67DOI: 10.1016/j.cbpa.2019.07.005

Hot EVs – how temperature affects extracellular vesicles

Schulz E, Karagianni A, Koch M, Fuhrmann G (2019)

European Journal of Pharmaceutics and BiopharmaceuticsDOI: 10.1016/j.ejpb.2019.11.010

Extracellular Vesicles—Connecting Kingdoms

Woith E, Fuhrmann G, Melzig M (2019)

International journal of molecular sciences, 20 (22)DOI: 10.3390/ijms20225695

Clinical Resistome Screening of 1,110 Escherichia coli Isolates Efficiently Recovers Diagnostically Relevant Antibiotic Resistance Biomarkers and Potential Novel Resistance Mechanisms

Volz C, Ramoni J, Beisken S, Galata V, Keller A, Plum A, Posch A, Müller R (2019)

Front. Microbiol., 10DOI: 10.3389/fmicb.2019.01671

Polyunsaturated fatty acid production by Yarrowia lipolytica employing designed myxobacterial PUFA synthases

Gemperlein K, Dietrich D, Kohlstedt M, Zipf G, Bernauer H, Wittmann C, Wenzel S, Müller R (2019)

Nat. Commun., 10 (1)DOI: 10.1038/s41467-019-12025-8

Production of a Dibrominated Aromatic Secondary Metabolite by a Planctomycete Implies Complex Interaction with a Macroalgal Host

Panter F, Garcia R, Thewes A, Zaburannyi N, Bunk B, Overmann J, Gutierrez M, Krug D, Müller R (2019)

ACS Chem. Biol., 14 (accepted // 12): 2713-2719DOI: 10.1021/acschembio.9b00641

Evaluation of the Storage Stability of Extracellular Vesicles

Richter M, Fuhrmann K, Fuhrmann G (2019)

Journal of visualized experiments : JoVE (147)DOI: 10.3791/59584

Two Biosynthetic Pathways in Jahnella thaxteri for Thaxteramides, Distinct Types of Lipopeptides

Oueis E, Klefisch T, Zaburannyi N, Garcia R, Plaza A, Müller R (2019)

Org. Lett., 21 (14): 5407-5412DOI: 10.1021/acs.orglett.9b01524

The role of protein–protein interactions in the biosynthesis of ribosomally synthesized and post-translationally modified peptides

Sikandar A, Koehnke J (2019)

Nat. Prod. Rep.DOI: 10.1039/C8NP00064F

Dedication: Heinz Floss and Christopher Walsh-pioneers in natural product chemical biology

Müller R, Wright G (2019)

Journal of Industrial Microbiology & BiotechnologyDOI: 10.1007/s10295-019-02139-9

Armeniaspirol Antibiotic Biosynthesis: Chlorination and Oxidative Dechlorination Steps Affording Spiro4.4non-8-ene

Fu C, Xie F, Hoffmann J, Wang Q, Bauer A, Brönstrup M, Mahmud T, Müller R (2019)

ChemBioChem, 20 (6): 764-769DOI: 10.1002/cbic.201800791

Heterologous expression of bacterial natural product biosynthetic pathways

Huo L, Hug J, Fu C, Bian X, Zhang Y, Müller R (2019)

Nat. Prod. Rep., 36: 1412-1436DOI: 10.1039/C8NP00091C

Genome mining reveals uncommon alkylpyrones as type III PKS products from myxobacteria

Hug J, Panter F, Krug D, Müller R (2019)

J. Ind. Microbiol. Biotechnol., 46 (3-4): 319-334DOI: 10.1007/s10295-018-2105-6

Class I Methyltransferase VioH Catalyzes Unusual S-Adenosyl-l-methionine Cyclization Leading to 4-Methylazetidinecarboxylic Acid Formation during Vioprolide Biosynthesis

Yan F, Müller R (2019)

ACS Chem. Biol., 14 (1): 99-105DOI: 10.1021/acschembio.8b00958

Novel Methoxymethacrylate Natural Products Uncovered by Statistics-Based Mining of the Myxococcus fulvus Secondary Metabolome

Panter F, Krug D, Müller R (2019)

ACS Chem. Biol., 14 (1): 88-98DOI: 10.1021/acschembio.8b00948

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