Publications
Publication Highlights
Have a look at our latest discoveries.
Publication database
2021
In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
Groß S, Schnell B, Haack P, Auerbach D, Müller R (2021)
Nat Commun 12 (1)DOI: 10.1038/s41467-021-21848-3
The sandarazols are cryptic and structurally unique plasmid encoded toxins from a rare myxobacterium
Panter F, Bader C, Müller R (2021)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202014671
N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa
Yahiaoui S, Voos K, Haupenthal J, Wichelhaus T, Frank D, Weizel L, Rotter M, Brunst S, Kramer J, Proschak E, Ducho C, Hirsch A (2021)
RSC Med. Chem.DOI: 10.1039/D1MD00187F
Crystalline sponge affinity screening: A fast tool for soaking condition optimization without the need of X-ray diffraction analysis
Rosenberger L, Essen C, Khutia A, Kühn C, Georgi K, Hirsch A, Hartmann R, Badolo L (2021)
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 164DOI: 10.1016/j.ejps.2021.105884
Non-Carbohydrate Glycomimetics as Inhibitors of Calcium(II)-Binding Lectins
Kuhaudomlarp S, Siebs E, Shanina E, Topin J, Joachim I, da Silva Figueiredo Celestino Gomes P, Varrot A, Rognan D, Rademacher C, Imberty A, Titz A (2021)
Angew. Chem. Int. Ed. 60 (15): 8104-8114DOI: 10.1002/anie.202013217
The exo-β-N-acetylmuramidase NamZ from Bacillus subtilis is the founding member of a family of exo-lytic peptidoglycan hexosaminidases
Müller M, Calvert M, Hottmann I, Kluj R, Teufel T, Balbuchta K, Engelbrecht A, Selim K, Xu Q, Borisova M, Titz A, Mayer C (2021)
The Journal of biological chemistry 296DOI: 10.1016/j.jbc.2021.100519
Sesbanimide R, a Novel Cytotoxic Polyketide Produced by Magnetotactic Bacteria
Awal R, Haack P, Bader C, Riese C, Schüler D, Müller R (2021)
mBio 12 (3)DOI: 10.1128/mBio.00591-21
Drug delivery to the inflamed intestinal mucosa- targeting technologies and human cell culture models for better therapies of IBD
Olga H, Shetab Boushehri Maryam A, Shalaby Karim S, Brigitta L, Alf L, Claus-Michael L (2021)
Advanced Drug Delivery ReviewsDOI: 10.1016/j.addr.2021.113828
Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane
Zamprogno P, Wüthrich S, Achenbach S, Thoma G, Stucki J, Hobi N, Schneider-Daum N, Lehr C, Huwer H, Geiser T, Schmid R, Guenat O (2021)
Communications Biology 4 (1)DOI: 10.1038/s42003-021-01695-0
A pulmonary mucus surrogate for investigating antibiotic permeation and activity against Pseudomonas aeruginosa biofilms
Frisch S, Boese A, Huck B, Horstmann J, Ho D, Schwarzkopf K, Murgia X, Loretz B, Souza Carvalho-Wodarz C, Lehr C (2021)
The Journal of antimicrobial chemotherapy 76 (6): 1472-1479DOI: 10.1093/jac/dkab068
A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms
Schütz C, Ho D, Hamed M, Abdelsamie A, Röhrig T, Herr C, Kany A, Rox K, Schmelz S, Siebenbürger L, …, Lehr C, Empting M (2021)
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8 (12)DOI: 10.1002/advs.202004369
Drug delivery for fighting infectious diseases: a global perspective
Loretz B, Oh Y, Hudson S, Gu Z, Lehr C (2021)
Drug delivery and translational research 11 (4): 1316-1322DOI: 10.1007/s13346-021-01009-1
Analysis and Optimization of Two Film-Coated Tablet Production Processes by Computer Simulation: A Case Study
Hering S, Schäuble N, Buck T, Loretz B, Rillmann T, Stieneker F, Lehr C (2021)
Processes 9 (1)DOI: 10.3390/pr9010067
Decoding (patho-)physiology of the lung by advanced in vitro models for developing novel anti-infectives therapies
Montefusco-Pereira C, Carvalho-Wodarz C, Seeger J, Kloft C, Michelet R, Lehr C (2021)
Drug Discovery Today 26 (1): 148-163DOI: 10.1016/j.drudis.2020.10.016
Testing of aerosolized ciprofloxacin nanocarriers on cystic fibrosis airway cells infected with P. aeruginosa biofilms
Juntke J, Murgia X, Günday Türeli N, Türeli A, Thorn C, Schneider M, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2021)
Drug delivery and translational research 11 (4): 1752-1765DOI: 10.1007/s13346-021-01002-8
Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals
Thiyagarajan D, Huck B, Nothdurft B, Koch M, Rudolph D, Rutschmann M, Feldmann C, Hozsa C, Furch M, Besecke K, …, Loretz B, Lehr C (2021)
Drug delivery and translational research 11 (4): 1766-1778DOI: 10.1007/s13346-021-01011-7
Formulation and evaluation of transdermal nanogel for delivery of artemether
Nnamani P, Ugwu A, Nnadi O, Kenechukwu F, Ofokansi K, Attama A, Lehr C (2021)
Drug delivery and translational research 11 (4): 1655-1674DOI: 10.1007/s13346-021-00951-4
Surfactant-Free Glibenclamide Nanoparticles: Formulation, Characterization and Evaluation of Interactions with Biological Barriers
Arrua E, Hartwig O, Ho D, Loretz B, Murgia X, Salomon C, Lehr C (2021)
Pharmaceutical research 38 (6): 1081-1092DOI: 10.1007/s11095-021-03056-2
A Custom-Made Device for Reproducibly Depositing Pre-metered Doses of Nebulized Drugs on Pulmonary Cells in vitro
Horstmann J, Thorn C, Carius P, Graef F, Murgia X, Souza Carvalho-Wodarz C, Lehr C (2021)
Frontiers in Bioengineering and Biotechnology 9DOI: 10.3389/fbioe.2021.643491
Fucosylated lipid nanocarriers loaded with antibiotics efficiently inhibit mycobacterial propagation in human myeloid cells
Durán V, Grabski E, Hozsa C, Becker J, Yasar H, Monteiro J, Costa B, Koller N, Lueder Y, Wiegmann B, …, Graalmann T, Kalinke U (2021)
Journal of controlled release : official journal of the Controlled Release Society 334: 201-212DOI: 10.1016/j.jconrel.2021.04.012
Microbiota and cancer: In vitro and in vivo models to evaluate nanomedicines
Ladaycia A, Loretz B, Passirani C, Lehr C, Lepeltier E (2021)
Advanced Drug Delivery Reviews 170: 44-70DOI: 10.1016/j.addr.2020.12.015
Development and evaluation of a quality control system based on transdermal electrical resistance for skin barrier function in vitro
Knoth K, Zäh R, Veldung B, Burgio D, Wiegand B, Smola H, Bock U, Lehr C, Hittinger M, Groß H (2021)
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)DOI: 10.1111/srt.12998
Tobramycin Liquid Crystal Nanoparticles Eradicate Cystic Fibrosis-Related Pseudomonas aeruginosa Biofilms
Thorn C, Carvalho-Wodarz C, Horstmann J, Lehr C, Prestidge C, Thomas N (2021)
Small (Weinheim an der Bergstrasse, Germany) 17 (24)DOI: 10.1002/smll.202100531
Extracellular vesicles as antigen carriers for novel vaccination avenues
Mehanny M, Lehr C, Fuhrmann G (2021)
Advanced Drug Delivery Reviews 173: 164-180DOI: 10.1016/j.addr.2021.03.016
Extracellular vesicles as novel assay tools to study cellular interactions of anti-infective compounds - A perspective
Richter R, Lehr C (2021)
Advanced Drug Delivery Reviews 173: 492-503DOI: 10.1016/j.addr.2021.04.010
Disease Models: Lung Models for Testing Drugs Against Inflammation and Infection
Carius P, Horstmann J, Souza Carvalho-Wodarz C, Lehr C (2021)
Handbook of experimental pharmacology 265: 157-186DOI: 10.1007/164_2020_366
Eap-functionalized liposomes as a bioinspired delivery system for oral delivery of colistin to treat intracellular Salmonella infection
Menina S (2021)
Book
Zebrafish: An Attractive Model to Study Staphylococcus aureus Infection and Its Use as a Drug Discovery Tool
Rasheed S, Fries F, Müller R, Herrmann J (2021)
Pharmaceuticals 14 (6)DOI: 10.3390/ph14060594
Design, synthesis, and biological evaluation of novel benzimidazole derivatives as sphingosine kinase 1 inhibitor
Khairat S, Omar M, Ragab F, Roy S, Turab Naqvi A, Abdelsamie A, Hirsch A, Galal S, Hassan M, El Diwani H (2021)
Archiv der PharmazieDOI: 10.1002/ardp.202100080
“Clicking“ fragment leads to novel dual-binding cholinesterase inhibitors
Moleda Z, Zawadzka A, Czarnocki Z, Monjas L, Hirsch A, Budzianowski A, Maurin J (2021)
Bioorg Med ChemDOI: 10.1016/j.bmc.2021.116269
Structure and biosynthesis of sorangipyranone - A new γ-dihydropyrone from the myxobacterial strain MSr12020
Okoth D, Hug J, Mándi A, Kurtán T, Garcia R, Müller R (2021)
Journal of Industrial Microbiology & BiotechnologyDOI: 10.1093/jimb/kuab029
Front Cover: Phosphonate as a Stable Zinc‐Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH) (ChemMedChem 8/2021)
Voos K, Schönauer E, Alhayek A, Haupenthal J, Andreas A, Müller R, Hartmann R, Brandstetter H, Hirsch A, Ducho C (2021)
ChemMedChem 16 (8): 1198-1198DOI: 10.1002/cmdc.202100229
Hit-optimization using target-directed dynamic combinatorial chemistry: Development of inhibitors of the anti-infective target 1-deoxy-D-xylulose-5-phosphate synthase
Jumde R, Guadigni M, Gierse R, Alhayek A, Di Zhu, Hamid Z, Johannsen S, Elgaher W, Neusens P, Nehls C, …, Reiling N, Hirsch A (2021)
Chemical ScienceDOI: 10.1039/D1SC00330E
miRMaster 2.0: multi-species non-coding RNA sequencing analyses at scale
Fehlmann T, Kern F, Laham O, Backes C, Solomon J, Hirsch P, Volz C, Müller R, Keller A (2021)
Nucleic Acids ResDOI: 10.1093/nar/gkab268
Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity
Ropponen H, Bader C, Diamanti E, Illarionov B, Rottmann M, Fischer M, Witschel M, Müller R, Hirsch A (2021)
ChemMedChemDOI: 10.1002/cmdc.202100067
Synergizing the potential of bacterial genomics and metabolomics to find novel antibiotics
Panter F, Bader C, Müller R (2021)
Chemical ScienceDOI: 10.1039/d0sc06919a
Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection
Mamareli P, Kruse F, Lu C, Guderian M, Floess S, Rox K, Allan D, Carlyle J, Brönstrup M, Müller R, …, Sparwasser T, Lochner M (2021)
Mucosal Immunol. 14 (1): 164-176DOI: 10.1038/s41385-020-0285-7
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis
Almeida L, Dhillon-LaBrooy A, Castro C, Adossa N, Carriche G, Guderian M, Lippens S, Dennerlein S, Hesse C, Lambrecht B, …, Moita L, Sparwasser T (2021)
Immunity 54 (1): 68-83DOI: 10.1016/j.immuni.2020.11.001
Stimulation of Probiotic Bacteria Induces Release of Membrane Vesicles with Augmented Anti-inflammatory Activity
Müller L, Kuhn T, Koch M, Fuhrmann G (2021)
ACS Appl. Bio Mater.DOI: 10.1021/acsabm.0c01136
Mastering the Gram-Negative Bacterial Barrier - Chemical Approaches to Increase Bacterial Bioavailability of Antibiotics
Ropponen H, Richter R, Hirsch A, Lehr C (2021)
Advanced Drug Delivery ReviewsDOI: 10.1016/j.addr.2021.02.014
Assessment of the rules related to gaining activity against Gram-negative bacteria
Ropponen H, Diamanti E, Siemens A, Illarionov B, Haupenthal J, Fischer M, Rottmann M, Witschel M, Hirsch A (2021)
RSC Med. Chem.DOI: 10.1039/D0MD00409J
Natural products in drug discovery: advances and opportunities
Atanasov A, Zotchev S, Dirsch V, Supuran C (2021)
Nature reviews. Drug discoveryDOI: 10.1038/s41573-020-00114-z
Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design
Axer A, Jumde R, Adam S, Faust A, Schäfers M, Fobker M, Koehnke J, Hirsch A, Gilmour R (2021)
Chem. Sci. 12 (4): 1286-1294DOI: 10.1039/D0SC04297H
Phosphonate as Stable Zinc-binding Group for Inhibitors of Clostridial Collagenase H (ColH) as Pathoblocker Agents
Voos K, Schönauer E, Alhayek A, Haupenthal J, Andreas A, Müller R, Hartmann R, Brandstetter H, Hirsch A, Ducho C (2021)
ChemMedChemDOI: 10.1002/cmdc.202000994
Expanding the Scope of Detectable Microbial Natural Products by Complementary Analytical Methods and Cultivation Systems
Bader C, Haack P, Panter F, Krug D, Müller R (2021)
Journal of natural productsDOI: 10.1021/acs.jnatprod.0c00942
Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties
Gierse R, Reddem E, Alhayek A, Baitinger D, Hamid Z, Jakobi H, Laber B, Lange G, Hirsch A, Groves (2021)
Biochemical and Biophysical Research Communications 539DOI: 10.1016/j.bbrc.2020.12.069
Kibdelosporangium persicum sp. nov., a new member of the Actinomycetes from a hot desert in Iran
Safaei N, Nouioui I, Mast Y, Zaburannyi N, Rohde M, Schumann P, Müller R, Wink J (2021)
Int J Syst Evol MicrobiolDOI: 10.1099/ijsem.0.004625
2020
Supercritical Fluid Extraction Enhances Discovery of Secondary Metabolites from Myxobacteria
Bader C, Neuber M, Panter F, Krug D, Müller R (2020)
Analytical chemistryDOI: 10.1021/acs.analchem.0c02995
An ambruticin-sensing complex modulates Myxococcus xanthus development and mediates myxobacterial interspecies communication
Marcos-Torres F, Volz C, Müller R (2020)
Nat Commun 11 (1)DOI: 10.1038/s41467-020-19384-7
PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus
Anversa Dimer F, Souza Carvalho-Wodarz C, Goes A, Cirnski K, Herrmann J, Schmitt V, Pätzold L, Abed N, Rossi C, Bischoff M, …, Müller R, Lehr C (2020)
Nanomedicine : nanotechnology, biology, and medicine 24DOI: 10.1016/j.nano.2019.102125
Protein‐Templated Hit Identification via an Ugi Four‐Component Reaction
Mancini F, Unver M, Elgaher W, Jumde V, Alhayek A, Lukat P, Herrmann J, Witte M, Köck M, Blankenfeldt W, Müller R, Hirsch A (2020)
Chem. Eur. J.DOI: 10.1002/chem.202002250
N -Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases
Konstantinovic J, Yahiaoui S, Alhayek A, Haupenthal J, Schönauer E, Andreas A, Kany A, Müller R, Koehnke J, Berger F, …, Brandstetter H, Hirsch A (2020)
J. Med. Chem. 63 (15): 8359-8368DOI: 10.1021/acs.jmedchem.0c00584
SphereCon-a method for precise estimation of residue relative solvent accessible area from limited structural information
Gress A, Kalinina O (2020)
Bioinformatics (Oxford, England) 36 (11): 3372-3378DOI: 10.1093/bioinformatics/btaa159
Probiomimetics-Novel Lactobacillus-Mimicking Microparticles Show Anti-Inflammatory and Barrier-Protecting Effects in Gastrointestinal Models
Kuhn T, Koch M, Fuhrmann G (2020)
Small (Weinheim an der Bergstrasse, Germany) 16 (40)DOI: 10.1002/smll.202003158
Novel PqsR Inverse Agonists
Hamed, M., Ahmed, S. A., Empting. M., Schütz, C., Hartmann, R. W., Röhrig, …, Hirsch, A. K. H. (2020)
Patent (EP20150119)
Novel PqsR Inverse Agonists
Hamed, M., Ahmed, S. A., Empting. M., Schütz, C., Hartmann, R. W., Röhrig, …, Hirsch, Anna K. H. (2020)
Patent (EP20150119)
Streptococcal Extracellular Membrane Vesicles Are Rapidly Internalized by Immune Cells and Alter Their Cytokine Release
Mehanny M, Koch M, Lehr C, Fuhrmann G (2020)
Frontiers in immunology 11DOI: 10.3389/fimmu.2020.00080
Dual-function chromogenic screening-based CRISPR/Cas9 genome editing system for actinomycetes
Wang Q, Xie F, Tong Y, Habisch R, Yang B, Zhang L, Müller R, Fu C (2020)
Applied Microbiology and Biotechnology 104 (1): 225-239DOI: 10.1007/s00253-019-10223-4
Tobacco Smoke and Inhaled Drugs Alter Expression and Activity of Multidrug Resistance-Associated Protein-1 (MRP1) in Human Distal Lung Epithelial Cells in vitro
Selo M, Delmas A, Springer L, Zoufal V, Sake J, Clerkin C, Huwer H, Schneider-Daum N, Lehr C, Nickel S, Langer O, Ehrhardt C (2020)
Frontiers in Bioengineering and Biotechnology 8DOI: 10.3389/fbioe.2020.01030
Towards a Continuous Manufacturing Process of Protein-Loaded Polymeric Nanoparticle Powders
Schiller S, Hanefeld A, Schneider M, Lehr C (2020)
AAPS PharmSciTech 21 (7)DOI: 10.1208/s12249-020-01814-w
A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria
Richter R, Kamal M, García-Rivera M, Kaspar J, Junk M, Elgaher W, Srikakulam S, Gress A, Beckmann A, Grißmer A, …, Schneider-Daum N, Lehr C (2020)
Materials today. Bio 8DOI: 10.1016/j.mtbio.2020.100084
Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection
Murgia X, Kany A, Herr C, Ho D, Rossi C, Bals R, Lehr C, Hirsch A, Hartmann R, Empting M, Röhrig T (2020)
Scientific Reports 10 (1)DOI: 10.1038/s41598-020-73459-5
Modulating the Barrier Function of Human Alveolar Epithelial (hAELVi) Cell Monolayers as a Model of Inflammation
Metz J, Wiegand B, Schnur S, Knoth K, Schneider-Daum N, Groß H, Croston G, Reinheimer T, Lehr C, Hittinger M (2020)
Alternatives to laboratory animals : ATLA 48 (5-6): 252-267DOI: 10.1177/0261192920983015
Spray-dried multidrug particles for pulmonary co-delivery of antibiotics with N-acetylcysteine and curcumin-loaded PLGA-nanoparticles
Lababidi N, Montefusco-Pereira C, Souza Carvalho-Wodarz C, Lehr C, Schneider M (2020)
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 157: 200-210DOI: 10.1016/j.ejpb.2020.10.010
Synthesis and Biopharmaceutical Characterization of Amphiphilic Squalenyl Derivative Based Versatile Drug Delivery Platform
Ho D, Christmann R, Murgia X, Rossi C, Frisch S, Koch M, Schaefer U, Loretz B, Desmaele D, Couvreur P, Lehr C (2020)
Frontiers in chemistry 8DOI: 10.3389/fchem.2020.584242
Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases
Christmann R, Ho D, Wilzopolski J, Lee S, Koch M, Loretz B, Vogt T, Bäumer W, Schaefer U, Lehr C (2020)
Pharmaceutics 12 (12)DOI: 10.3390/pharmaceutics12121131
Predicting Bacterial Accumulation of Anti-infectives by Measuring Permeability across Surrogates of the Gram-negative Bacterial Cell Envelope
Richter R (2020)
Book
Predicting Bacterial Accumulation of Anti-infectives by Measuring Permeability across Surrogates of the Gram-negative Bacterial Cell Envelope
Richter R (2020)
Book
Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics
Grandclaudon C, Birudukota N, Elgaher W, Jumde R, Yahiaoui S, Arisetti N, Hennessen F, Hüttel S, Stadler M, Herrmann J, …, Hirsch A, Brönstrup M (2020)
European journal of medicinal chemistry 188DOI: 10.1016/j.ejmech.2019.112005
Discovery of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions via Dynamic Combinatorial Chemistry
Hartman A, Elgaher W, Hertrich N, Andrei S, Ottmann C, Hirsch A (2020)
ACS medicinal chemistry letters 11 (5): 1041-1046DOI: 10.1021/acsmedchemlett.9b00541
Characterization of bromelain indicates a molar excess of inhibitor vs. enzyme molecules, a Jacalin-like lectin and Maillard reaction products
Gross P, Seelert H, Meiser P, Müller R (2020)
Journal of pharmaceutical and biomedical analysis 181DOI: 10.1016/j.jpba.2019.113075
Synthetic and Biological Studies on New Urea and Triazole Containing Cystobactamid Derivatives
Planke T, Cirnski K, Herrmann J, Müller R, Kirschning A (2020)
Chem. Eur. J. 26 (19): 4289-4296DOI: 10.1002/chem.201904073
The glucocorticoid-induced leucine zipper mediates statin-induced muscle damage
Hoppstädter J, Valbuena Perez J, Linnenberger R, Dahlem C, Legroux T, Hecksteden A, Tse W, Flamini S, Andreas A, Herrmann J, …, Bruscoli S, Kiemer A (2020)
FASEB j. 34 (3): 4684-4701DOI: 10.1096/fj.201902557RRR
Myxobacteria-Derived Outer Membrane Vesicles: Potential Applicability Against Intracellular Infections
Goes A, Lapuhs P, Kuhn T, Schulz E, Richter R, Panter F, Dahlem C, Koch M, Garcia R, Kiemer A, Müller R, Fuhrmann G (2020)
Cells 9 (1)DOI: 10.3390/cells9010194
Toxicokinetics and toxicodynamics of the fentanyl homologs cyclopropanoyl-1-benzyl-4´-fluoro-4-anilinopiperidine and furanoyl-1-benzyl-4-anilinopiperidine
Gampfer T, Wagmann L, Park Y, Cannaert A, Herrmann J, Fischmann S, Westphal F, Müller R, Stove C, Meyer M (2020)
Arch. Toxicol. 94 (6): 2009-2025DOI: 10.1007/s00204-020-02726-1
The ROK like protein of Myxococcus xanthus DK1622 acts as a pleiotropic transcriptional regulator for secondary metabolism
Izzat S, Rachid S, Ajdidi A, El-Nakady Y, Liu X, Ye B, Müller R (2020)
J. Biotechnol. 311: 25-34DOI: 10.1016/j.jbiotec.2020.02.005
Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics
Elgaher W, Hamed M, Baumann S, Herrmann J, Siebenbürger L, Krull J, Cirnski K, Kirschning A, Brönstrup M, Müller R, Hartmann R (2020)
Chem. Eur. J. 26 (32): 7219-7225DOI: 10.1002/chem.202000117
Dual-Seq reveals genome and transcriptome of Caedibacter taeniospiralis, obligate endosymbiont of Paramecium
Pirritano M, Zaburannyi N, Grosser K, Gasparoni G, Müller R, Simon M, Schrallhammer M (2020)
Sci. Rep. 10 (1)DOI: 10.1038/s41598-020-65894-1
Thioholgamide A, a New Anti-Proliferative Anti-Tumor Agent, Modulates Macrophage Polarization and Metabolism
Dahlem C, Siow W, Lopatniuk M, Tse W, Kessler S, Kirsch S, Hoppstädter J, Vollmar A, Müller R, Luzhetskyy A, Bartel K, Kiemer A (2020)
Cancers 12 (5)DOI: 10.3390/cancers12051288
Human microbial metabolite mimicry as a strategy to expand the chemical space of potential drugs
Li H, Ranhotra H, Mani S, Dvorák Z, Sokol H, Müller R (2020)
Drug Discov. Today 25 (9): 1575-1579DOI: 10.1016/j.drudis.2020.06.007
ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli
Wallenstein A, Rehm N, Brinkmann M, Selle M, Bossuet-Greif N, Sauer D, Bunk B, Spröer C, Wami H, Homburg S, …, Müller R, Dobrindt U (2020)
mSphere 5 (4)DOI: 10.1128/mSphere.00591-20
Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin
Hennessen F, Miethke M, Zaburannyi N, Loose M, Lukežic T, Bernecker S, Hüttel S, Jansen R, Schmiedel J, Fritzenwanker M, …, Herrmann J, Müller R (2020)
Antibiotics 9 (9)DOI: 10.3390/antibiotics9090619
How to Study the Metabolism of New Psychoactive Substances for the Purpose of Toxicological Screenings-A Follow-Up Study Comparing Pooled Human Liver S9, HepaRG Cells, and Zebrafish Larvae
Wagmann L, Frankenfeld F, Park Y, Herrmann J, Fischmann S, Westphal F, Müller R, Flockerzi V, Meyer M (2020)
Frontiers in chemistry 8DOI: 10.3389/fchem.2020.00539
Natural Products Impacting DNA Methyltransferases and Histone Deacetylases
Akone S, Ntie-Kang F, Stuhldreier F, Ewonkem M, Noah A, Mouelle S, Müller R (2020)
Frontiers in pharmacology 11DOI: 10.3389/fphar.2020.00992
Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus-Based Wound Infection Model in SKH1 Mice
Haupenthal J, Kautz Y, Elgaher W, Pätzold L, Röhrig T, Laschke M, Tschernig T, Hirsch A, Molodtsov V, Murakami K, Hartmann R, Bischoff M (2020)
ACS infectious diseases 6 (10): 2573-2581DOI: 10.1021/acsinfecdis.0c00034
Editorial: Mechanisms of Prokaryotic Predation
Whitworth D, Jurkevitch E, Pérez J, Fuhrmann G, Koval S (2020)
Frontiers in microbiology 11DOI: 10.3389/fmicb.2020.02071
Inhibitors of Pseudomonas aeruginosa virulence factor
Kaya, C., Konstantinovic, J., Voos, K., Walter, I., Kany, A.M., …, Hirsch, Anna K. H. (2020)
Patent (EP20192608.6)
Heterologous expression of the atypical tetracycline chelocardin reveals the full set of genes required for its biosynthesis
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Microb. Cell Fact. 19 (1)DOI: 10.1186/s12934-020-01495-x
François Diederich – In Memoriam**
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ChemMedChemDOI: 10.1002/cmdc.202000920
Frontispiece: Protein‐Templated Hit Identification through an Ugi Four‐Component Reaction
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Chemistry – A European Journal 26 (64)DOI: 10.1002/chem.202086462
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Leben und Überleben im Boden: Myxococcus xanthus ist Mikrobe des Jahres 2020
Volz C, Krug D, Müller R (2020)
Biol. Unserer Zeit 50 (6): 424-432DOI: 10.1002/biuz.202010721
The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase
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Proc. Natl. Acad. Sci. U.S.A.DOI: 10.1073/pnas.2013706117
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Journal of medicinal chemistry 63 (20): 11707-11724DOI: 10.1021/acs.jmedchem.0c00856
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BookDOI: 10.1101/2020.05.14.095695
Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model
Park Y, Meyer M, Müller R, Herrmann J (2020)
Molecules 25 (19)DOI: 10.3390/molecules25194474
2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene-Nucleoside
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Molecules (Basel, Switzerland) 25 (11)DOI: 10.3390/molecules25112676
Biosynthesis of Cittilins, Unusual Ribosomally Synthesized and Post-translationally Modified Peptides from Myxococcus xanthus
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ACS chemical biology 15 (8): 2221-2231DOI: 10.1021/acschembio.0c00430
7-Hydroxycoumarins are Affinity-based Fluorescent Probes for Competitive Binding Studies of Macrophage Migration Inhibitory Factor
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Polymer-Cargo-Complexes compremising cross-linked copolymers and cargo molecules
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N-Aryl Mercaptopropionamides as inhibitors of Metallo-ß-Lactamases
Yahiaoui, S., Kaya, C., Kany, A. M., Haupenthal, J., Wichelhaus, T., …, Hirsch, Anna K. H. (2020)
Patent (EP20164855.7)
Advancing human in vitro pulmonary disease models in preclinical research: opportunities for lung-on-chips
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Nanoparticle Targeting to Scalp Hair Follicles: New Perspectives for a Topical Therapy for Alopecia Areata
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Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections
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Safety assessment of excipients (SAFE) for orally inhaled drug products
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Itaconic Acid Increases the Efficacy of Tobramycin against Pseudomonas aeruginosa Biofilms
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pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers
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Design and in vitro characterization of multistage silicon-PLGA budesonide particles for inflammatory bowel disease
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 151: 61-72DOI: 10.1016/j.ejpb.2020.03.020
P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives
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Inhalationstoxizität von Nanopartikeln // The role of alveolar macrophages in biokinetics and biological effects of inhaled nanoparticles
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Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach
Markella Konstantinidou, Francesca Magari, Fandi Sutanto, Jörg Haupenthal, Varsha R. Jumde, M. Yagiz Ünver, Andreas Heine, Carlos Jamie Camacho, Hirsch A, Gerhard Klebe, Alexander Dömling (2020)
ChemMedChem 15 (8): 680-684DOI: 10.1002/cmdc.202000024
Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling
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Optimized Inhibitors of MDM2 via an Attempted Protein‐Templated Reductive Amination
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BOPC1 Enantiomers Preparation and HuR Interaction Study. From Molecular Modeling to a Curious DEEP-STD NMR Application
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Synthesis and Biological Evaluation of Novel 2-Substituted Analogues of (–)-Pentenomycin I
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Validating the 1,2-Difluoro Motif As a Hybrid Bioisostere of CF3 and Et Using Matrix Metalloproteinases As Structural Probes
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Discovery of Antibacterial Agents Inhibiting the Energy-Coupling Factor (ECF) Transporters by Structure-Based Virtual Screening
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Potential Dental Biofilm Inhibitors: Dynamic Combinatorial Chemistry Affords Sugar-Based Molecules that Target Bacterial Glucosyltransferase
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A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d -galactose pentaacetate
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Resistance-associated substitutions in patients with chronic hepatitis C virus genotype 4 infection
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A shift of dynamic equilibrium between the KIT active and inactive states causes drug resistance
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Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy
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Discovery of Novel Latency-Associated Nuclear Antigen Inhibitors as Antiviral Agents Against Kaposi's Sarcoma-Associated Herpesvirus
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Restriction-Free Construction of a Phage-Presented Very Short Macrocyclic Peptide Library
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New PqsR Inverse Agonists
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Zivko C, Fuhrmann G, Luciani P (2020)
Biochimica et Biophysica Acta - General Subjects 1865 (4)DOI: 10.1016/j.bbagen.2020.129559
Diffusion and transport of extracellular vesicles
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Expression, Purification, and Functional Characterization of Tectonin 2 from Laccaria bicolor: A Six-Bladed Beta-Propeller Lectin Specific for O-Methylated Glycans
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Bacteria as genetically programmable producers of bioactive natural products
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Host Development for Heterologous Expression and Biosynthetic Studies of Myxobacterial Natural Products
Hug J, Müller R (2020)
In pressDOI: 10.1016/B978-0-12-409547-2.14818-8
Myxobakterielle Naturstofffabriken
Krug D, Garcia R, Müller R (2020)
Biospektrum 26 (1): 32-36DOI: 10.1007/s12268-020-1334-1
Hot EVs – how temperature affects extracellular vesicles
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European Journal of Pharmaceutics and Biopharmaceutics 146: 55-63DOI: 10.1016/j.ejpb.2019.11.010
In depth natural product discovery - Myxobacterial strains that provided multiple secondary metabolites
Bader C, Panter F, Müller R (2020)
Biotechnol Adv. 39DOI: 10.1016/j.biotechadv.2019.107480