Personen | HIPS | HELMHOLTZ HIPS

2024

Isolation of Fidaxomicin and Shunt Metabolites from Actinoplanes deccanensis

Jung E, Hunter M, Dorst A, Major A, Teofilovic T, Müller R, Gademann K (2024)

HCADOI: 10.1002/hlca.202400013

The Peptide Antibiotic Corramycin Adopts a β-Hairpin-like Structure and Is Inactivated by the Kinase ComG

Adam S, Fries F, Tesmar A, Rasheed S, Deckarm S, Sousa C, Reberšek R, Risch T, Mancini S, Herrmann J, …, Kalinina O, Müller R (2024)

J. Am. Chem. Soc.DOI: 10.1021/jacs.3c13208

Inhibitory effect of sorangicin A against mutant DNA-dependent RNA polymerase in the obligate intracellular bacterium Chlamydia trachomatis

Li Q, Jansen H, Hansen G, Nurjadi D, Herrmann J, Stadler M, Brönstrup M, Müller R, He C, Graspeuntner S, Rupp J, Shima K (2024)

Int. J. Antimicrob. AgentsDOI: 10.1016/j.ijantimicag.2024.107132

Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence

Brand M, Ritzmann F, Kattler K, Milasius D, Yao Y, Herr C, Kirsch S, Müller R, Yildiz D, Bals R, Beisswenger C (2024)

Respir. Res. 25 (1)DOI: 10.1186/s12931-023-02636-7

Nitroxoline resistance is associated with significant fitness loss and diminishes in vivo virulence of Escherichia coli

Deschner F, Risch T, Baier C, Schlüter D, Herrmann J, Müller R (2024)

Microbiology Spectrum 12 (1)DOI: 10.1128/spectrum.03079-23

Is Simultaneous Binding to DNA and Gyrase Important for the Antibacterial Activity of Cystobactamids?

Solga D, Wieske L, Wilcox S, Zeilinger C, Jansen-Olliges L, Cirnski K, Herrmann J, Müller R, Erdelyi M, Kirschning A (2024)

Chem. Eur. J.DOI: 10.1002/chem.202303796

New myxobacteria of the Myxococcaceae clade produce angiolams with antiparasitic activities

Walesch S, Garcia R, Mahmoud A, Panter F, Bollenbach S, Mäser P, Kaiser M, Krug D, Müller R (2024)

Microbiology SpectrumDOI: 10.1128/spectrum.03689-23

Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents

Khalifa H, Rasheed S, Haupenthal J, Herrmann J, Mandour Y, Abadi A, Engel M, Müller R, Hirsch A, Abdel-Halim M, Hamed M (2024)

Archiv der PharmazieDOI: 10.1002/ardp.202300656

Mining the microbiota for antibiotics

Beemelmanns C, Keller A, Müller R (2024)

Nat. Microbiol. 9 (1): 13-14DOI: 10.1038/s41564-023-01568-8

Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins

Fu C, Liu Y, Walt C, Rasheed S, Bader C, Lukat P, Neuber M, Haeckl F, Blankenfeldt W, Kalinina O, Müller R (2024)

Nat Commun 15 (1)DOI: 10.1038/s41467-024-44953-5

2023

3D bioprinting ofE. coliMG1655 biofilms on human lung epithelial cells for building complexin vitroinfection models

Aliyazdi S, Frisch S, Hidalgo A, Frank N, Krug D, Müller R, Schaefer U, Vogt T, Loretz B, Lehr C (2023)

Biofabrication 15 (3)DOI: 10.1088/1758-5090/acd95e

Discovery and Characterization of a Myxobacterial Lanthipeptide with Unique Biosynthetic Features and Anti-inflammatory Activity

Wang X, Chen X, Wang Z, Zhuang M, Zhong L, Fu C, Garcia R, Müller R, Zhang Y, Yan J, Wu D, Huo L (2023)

J. Am. Chem. Soc. 145 (30): 16924-16937DOI: 10.1021/jacs.3c06014

Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections

Konstantinovic J, Kany A, Alhayek A, Abdelsamie A, Sikandar A, Voos K, Yao Y, Andreas A, Shafiei R, Loretz B, …, Haupenthal J, Hirsch A (2023)

ACS Cent. Sci. 9 (12): 2205-2215DOI: 10.1021/acscentsci.3c01102

Molecular replacement for small-molecule crystal structure determination from X-ray and electron diffraction data with reduced resolution

Gorelik T, Lukat P, Kleeberg C, Blankenfeldt W, Mueller R (2023)

Acta crystallographica. Section A, Foundations and advances 79 (Pt 6): 504-514DOI: 10.1107/S2053273323008458

Darobactine: eine neue Antibiotikaklasse in Entwicklung

Seyfert C, Porten C, Müller R (2023)

Biospektrum 29 (5): 539-541DOI: 10.1007/s12268-023-1988-6

ABC-HuMi: the Atlas of Biosynthetic Gene Clusters in the Human Microbiome

Hirsch P, Tagirdzhanov A, Kushnareva A, Olkhovskii I, Graf S, Schmartz G, Hegemann J, Bozhüyük K, Müller R, Keller A, Gurevich A (2023)

Nucleic Acids ResDOI: 10.1093/nar/gkad1086

New Genetically Engineered Derivatives of Antibacterial Darobactins Underpin Their Potential for Antibiotic Development

Seyfert C, Müller A, Walsh D, Birkelbach J, Kany A, Porten C, Yuan B, Krug D, Herrmann J, Marlovits T, Hirsch A, Müller R (2023)

J. Med. Chem.DOI: 10.1021/acs.jmedchem.3c01660

Discovery and overproduction of novel highly bioactive pamamycins through transcriptional engineering of the biosynthetic gene cluster

Eckert N, Rebets Y, Horbal L, Zapp J, Herrmann J, Busche T, Müller R, Kalinowski J, Luzhetskyy A (2023)

Microb. Cell Fact. 22 (1)DOI: 10.1186/s12934-023-02231-x

Tartrolon sensing and detoxification by the Listeria monocytogenes timABR resistance operon

Engelgeh T, Herrmann J, Jansen R, Müller R, Halbedel S (2023)

BookDOI: 10.1101/2023.07.27.550809

New Genetically Engineered Derivatives of Antibacterial Darobac-tins Underpin their Potential for Antibiotic Development

Seyfert C, Müller A, Walsh D, Birkelbach J, Kany A, Porten C, Yuan B, Krug D, Herrmann J, Marlovits T, Hirsch A, Müller R (2023)

BookDOI: 10.26434/chemrxiv-2023-24tmj

Inhibitors of the Elastase LasB for the treatment of Pseudomonas aeruginosa lung infections

Konstantinovic J, Kany A, Alhayek A, Abdelsamie A, Sikandar A, Voos K, Yao Y, Andreas A, Shafiei R, Loretz B, …, Haupenthal J, Hirsch A (2023)

DOI: 10.26434/chemrxiv-2023-bszcb

Artificial intelligence for natural product drug discovery

Mullowney M, Duncan K, Elsayed S, Garg N, van der Hooft J, Martin N, Meijer D, Terlouw B, Biermann F, Blin K, …, Robinson S, Medema M (2023)

Nat Rev Drug DiscovDOI: 10.1038/s41573-023-00774-7

Impact of Drug Administration Routes on the In Vivo Efficacy of the Natural Product Sorangicin a Using a Staphylococcus aureus Infection Model in Zebrafish Embryos

Fries F, Kany A, Rasheed S, Hirsch A, Müller R, Herrmann J (2023)

International journal of molecular sciences 24 (16)DOI: 10.3390/ijms241612791

Optimization of Mass Spectrometry Imaging for Drug Metabolism and Distribution Studies in the Zebrafish Larvae Model: A Case Study with the Opioid Antagonist Naloxone

Park Y, Meyer M, Müller R, Herrmann J (2023)

International journal of molecular sciences 24 (12)DOI: 10.3390/ijms241210076

Revision of the Absolute Configurations of Chelocardin and Amidochelocardin

Sikandar A, Popoff A, Jumde R, Mándi A, Kaur A, Elgaher W, Rosenberger L, Hüttel S, Jansen R, Hunter M, …, Kurtán T, Müller R (2023)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202306437

In Vitro Activity of Two Novel Antimicrobial Compounds on MDR-Resistant Clinical Isolates

Rima M, Pfennigwerth N, Cremanns M, Cirnski K, Oueslati S, Gatermann S, d’Amélio N, Herrmann J, Müller R, Naas T (2023)

Antibiotics 12 (8)DOI: 10.3390/antibiotics12081265

The mycobacterial ImuA'-ImuB-DnaE2 mutasome: composition and recruitment in live cells

Gessner S, Martin Z, Reiche M, Santos J, Dinkele R, Ramudzuli A, Dhar N, Wet T, Anoosheh S, Lang D, …, Lamers M, Warner D (2023)

eLife 12DOI: 10.7554/eLife.75628

Quantification of Plasmodium falciparum HRP-2 as an alternative method to 3Hhypoxanthine incorporation to measure the parasite reduction ratio in vitro

Carvalho L, Niepoth E, Mavraj-Husejni A, Kreidenweiss A, Herrmann J, Müller R, Knaab T, Burckhardt B, Kurz T, Held J (2023)

Int. J. Antimicrob. Agents 62 (3)DOI: 10.1016/j.ijantimicag.2023.106894

Schatztruhe Menschliches Mikrobiom: Wie Naturstoffe Uns Beeinflus...: Ingenta Connect

Schumm C, Donate P, Hegemann J, Keller A, Beemelmanns C, Müller R (2023)

Pharmakon 11 (4): 290-297DOI: 10.1691/pn.20230032

The Disorazole Z Family of Highly Potent Anticancer Natural Products from Sorangium cellulosum: Structure, Bioactivity, Biosynthesis, and Heterologous Expression

Gao Y, Birkelbach J, Fu C, Herrmann J, Irschik H, Morgenstern B, Hirschfelder K, Li R, Zhang Y, Jansen R, Müller R (2023)

Microbiology SpectrumDOI: 10.1128/spectrum.00730-23

Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis

Adam S, Zheng D, Klein A, Volz C, Mullen W, Shirran S, Smith B, Kalinina O, Müller R, Koehnke J (2023)

Nature chemistry 15 (4): 560-568DOI: 10.1038/s41557-023-01153-w

Insights into the biosynthesis of icumazole, unveiling a distinctive family of crotonyl-CoA carboxylase/reductase

Xie F, Kiefer A, Hirsch A, Kalinina O, Fu C, Müller R (2023)

Cell Reports Physical Science 4 (5)DOI: 10.1016/j.xcrp.2023.101394

Engineered Biosynthesis of Complex Disorazol Polyketides in a Streamlined Burkholderia thailandensis

Wang Z, Liu X, Zhou H, Liu Y, Tu Q, Huo L, Yan F, Müller R, Zhang Y, Xu X (2023)

ACS synthetic biology 12 (4): 971-977DOI: 10.1021/acssynbio.2c00610

Genome-Guided Discovery of the Myxobacterial Thiolactone-Containing Sorangibactins

Gao Y, Walt C, Bader C, Müller R (2023)

ACS chemical biology 18 (4): 924-932DOI: 10.1021/acschembio.3c00063

Evaluation of extraction methods for untargeted metabolomic studies for future applications in zebrafish larvae infection models

Schippers P, Rasheed S, Park Y, Risch T, Wagmann L, Hemmer S, Manier S, Müller R, Herrmann J, Meyer M (2023)

Sci. Rep. 13 (1)DOI: 10.1038/s41598-023-34593-y

Structure Elucidation and Biosynthesis of Nannosterols A and B, Myxobacterial Sterols from Nannocystis sp. MNa10993

Akone S, Hug J, Kaur A, Garcia R, Müller R (2023)

Journal of natural products 86 (4): 915-923DOI: 10.1021/acs.jnatprod.2c01143

Sorangicin A Is Active against Chlamydia in Cell Culture, Explanted Fallopian Tubes, and Topical In Vivo Treatment

Graspeuntner S, Koethke K, Scholz C, Semmler L, Lupatsii M, Kirchhoff L, Herrmann J, Rox K, Wittstein K, Käding N, …, Shima K, Rupp J (2023)

Antibiotics 12 (5)DOI: 10.3390/antibiotics12050795

The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection

Bublitz A, Brauer M, Wagner S, Hofer W, Müsken M, Deschner F, Lesker T, Neumann-Schaal M, Paul L, Nübel U, …, Fuchs T, Strowig T (2023)

Cell Host MicrobeDOI: 10.1016/j.chom.2023.04.003

Identification of Compounds Preventing A. fumigatus Biofilm Formation by Inhibition of the Galactosaminogalactan Deacetylase Agd3

Seegers C, Lee D, Zarnovican P, Kirsch S, Müller R, Haselhorst T, Routier F (2023)

International journal of molecular sciences 24 (3)DOI: 10.3390/ijms24031851

The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition

Koller T, Scheid U, Kösel T, Herrmann J, Krug D, Boshoff H, Beckert B, Evans J, Schlemmer J, Sloan B, …, Wilson D, Müller R (2023)

J. Am. Chem. Soc. 145 (2): 851-863DOI: 10.1021/jacs.2c08816

Fighting antibiotic resistance-strategies and (pre)clinical developments to find new antibacterials

Walesch S, Birkelbach J, Jézéquel G, Haeckl F, Hegemann J, Hesterkamp T, Hirsch A, Hammann P, Müller R (2023)

EMBO reports 24 (1)DOI: 10.15252/embr.202256033

Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization

Girardini M, Ferlenghi F, Annunziato G, Degiacomi G, Papotti B, Marchi C, Sammartino J, Rasheed S, Contini A, Pasca M, …, Costantino G, Pieroni M (2023)

European journal of medicinal chemistry 245DOI: 10.1016/j.ejmech.2022.114916

2022

Total In Vitro Biosynthesis of the Thioamitide Thioholgamide and Investigation of the Pathway

Sikandar A, Lopatniuk M, Luzhetskyy A, Müller R, Koehnke J (2022)

J. Am. Chem. Soc. 144 (11): 5136-5144DOI: 10.1021/jacs.2c00402

Stereoselective Syntheses of Deuterated Pipecolic Acids as Tools to Investigate the Stereoselectivity of the Hydroxylase GetF

Neis N, Xie F, Krug D, Zhao H, Siebert A, Binz T, Fu C, Müller R, Kazmaier U (2022)

Liebigs Ann. 2022 (13)DOI: 10.1002/ejoc.202200162

Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes

Gavriilidou A, Kautsar S, Zaburannyi N, Krug D, Müller R, Medema M, Ziemert N (2022)

Nat. Microbiol. 7 (5): 726-735DOI: 10.1038/s41564-022-01110-2

Crystal structure of natural product argyrin-D determined by 3D electron diffraction

Gorelik T, Tehrani K, Gruene T, Monecke T, Niessing D, Kaiser U, Blankenfeldt W, Müller R (2022)

CrystEngComm 24 (33): 5885-5889DOI: 10.1039/D2CE00707J

Bursts in biosynthetic gene cluster transcription are accompanied by surges of natural compound production in the myxobacterium Sorangium sp

Boldt J, Lukoševiciute L, Fu C, Steglich M, Bunk B, Junker V, Gollasch A, Trunkwalter B, Mohr K, Beckstette M, …, Müller R, Nübel U (2022)

BookDOI: 10.1101/2022.11.24.517636

Persicamidines-Unprecedented Sesquarterpenoids with Potent Antiviral Bioactivity against Coronaviruses

Keller L, Oueis E, Kaur A, Safaei N, Kirsch S, Gunesch A, Haid S, Rand U, Cicin-Šain L, Fu C, …, Pietschmann T, Müller R (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202214595

Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape

Lee S, Nasr S, Rasheed S, Liu Y, Hartwig O, Kaya C, Boese A, Koch M, Herrmann J, Müller R, …, Hirsch A, Lehr C (2022)

Journal of controlled release : official journal of the Controlled Release Society 353: 915-929DOI: 10.1016/j.jconrel.2022.12.018

Darobactins Exhibiting Superior Antibiotic Activity by Cryo-EM Structure Guided Biosynthetic Engineering

Seyfert C, Porten C, Yuan B, Deckarm S, Panter F, Bader C, Coetzee J, Deschner F, Tehrani K, Higgins P, …, Herrmann J, Müller R (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202214094

Current Developments in Antibiotic Discovery – Global Microbial Diversity as Source for Evolutionary Optimized Anti-infectives

Hegemann J, Birkelbach J, Walesch S, Müller R (2022)

EMBO Rep. published concurrently

Current Developments in Antibiotic Discovery – Global Microbial Diversity as Source for Evolutionary Optimized Anti-infectives

Hegemann J, Birkelbach J, Walesch S, Müller R (2022)

EMBO Rep. published concurrently

The inherent antibiotic activity of myxobacteria-derived autofluorescent outer membrane vesicles is switched on and off by light stimulation

Lapuhs P, Heinrich E, Garcia R, Goes A, Frank N, Bollenbach L, Stibane V, Kuhn T, Koch M, Kiemer A, …, Fuhrmann K, Fuhrmann G (2022)

NanoscaleDOI: 10.1039/d2nr02743g

Large-Scale Interlaboratory DI-FT-ICR MS Comparability Study Employing Various Systems

Forcisi S, Moritz F, Thompson C, Kanawati B, Uhl J, Afonso C, Bader C, Barsch A, Boughton B, Chu R, …, Laukien F, Schmitt-Kopplin P (2022)

Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.2c00082

Total synthesis of Myxoprincomide, a secondary metabolite from Myxococcus xanthus

Kohr M, Walt C, Dastbaz J, Müller R, Kazmaier U (2022)

Org. Biomol. Chem.DOI: 10.1039/d2ob02021a

Pineapple Lectin AcmJRL binds SARS-CoV-2 Spike Protein in a carbohydrate-dependent fashion

Meiers J, Dastbaz J, Adam S, Rasheed S, Kirsch S, Meiser P, Gross P, Müller R, Titz A (2022)

Chembiochem : a European journal of chemical biologyDOI: 10.1002/cbic.202200463

The Glycan-Specificity of the Pineapple Lectin AcmJRL and its Carbohydrate-Dependent Binding of the SARS-CoV-2 Spike Protein

Meiers J, Dastbaz J, Adam S, Rasheed S, Kirsch S, Meiser P, Gross P, Müller R, Titz A (2022)

BookDOI: 10.1101/2022.05.27.493400

Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening

Di Zhu, Johannsen S, Masini T, Simonin C, Haupenthal J, Illarionov B, Andreas A, Awale M, Gierse R, van der Laan T, …, Reymond J, Hirsch A (2022)

Chem. Sci. 13 (36): 10686-10698DOI: 10.1039/D2SC02371G

Expanding the Ajudazol Cytotoxin Scaffold: Insights from Genome Mining, Biosynthetic Investigations, and Novel Derivatives

Zeng H, Birkelbach J, Hoffmann J, Popoff A, Volz C, Müller R (2022)

Journal of natural productsDOI: 10.1021/acs.jnatprod.2c00637

Interference with lipoprotein maturation sensitizes methicillin-resistant Staphylococcus aureus to human group IIA secreted phospholipase A 2 and daptomycin

Kuijk M, Wu Y, van Hensbergen V, Shanlitourk G, Payré C, Lambeau G, Herrmann J, Müller R, van Strijp J, Pannekoek Y, Touqui L, van Sorge N (2022)

BookDOI: 10.1101/2022.02.06.476181

Natural products lysobactin and sorangicin A show in vitro activity against Mycobacterium abscessus complex

Sullivan J, Yao J, Courtine C, Lupien A, Herrmann J, Müller R, Behr M (2022)

BookDOI: 10.1101/2022.06.27.497873

Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA

Fathalla R, Fröhner W, Bader C, Fischer P, Dahlem C, Chatterjee D, Mathea S, Kiemer A, Arthanari H, Müller R, …, Ducho C, Engel M (2022)

Journal of medicinal chemistryDOI: 10.1021/acs.jmedchem.2c01275

Pharmacology and early ADMET data of corallopyronin A, a natural product with macrofilaricidal anti-wolbachial activity in filarial nematodes

Ehrens A, Schiefer A, Krome A, Becker T, Rox K, Neufeld H, Aden T, Wagner K, Müller R, Grosse M, …, Pfarr K, Hoerauf A (2022)

Front. Trop. Dis 3DOI: 10.3389/fitd.2022.983107

A novel tumor-targeting strain of Xenorhabdus stockiae exhibits potent biological activities

Zhang C, Chen H, Hüttel S, Hu S, Zhang W, Ding X, Yin J, Yin Y, Müller R, Xia L, Zhang Y, Tu Q (2022)

Frontiers in Bioengineering and Biotechnology 10DOI: 10.3389/fbioe.2022.984197

Discovery, Biosynthesis and Biological Activity of a Succinylated Myxochelin from the Myxobacterial strain MSr12020

Okoth D, Hug J, Garcia R, Müller R (2022)

BookDOI: 10.20944/preprints202209.0147.v1

Thiamyxins: Structure and Biosynthesis of Myxobacterial RNA-Virus Inhibitors

Haack P, Harmrolfs K, Bader C, Garcia R, Gunesch A, Haid S, Popoff A, Voltz A, Kim H, Bartenschlager R, Pietschmann T, Müller R (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202212946

Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin

Couturier C, Groß S, Tesmar A, Hoffmann J, Deckarm S, Fievet A, Dubarry N, Taillier T, Pöverlein C, Stump H, …, Müller R, Renard S (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202210747

BusyBee Web: towards comprehensive and differential composition-based metagenomic binning

Schmartz G, Hirsch P, Amand J, Dastbaz J, Fehlmann T, Kern F, Müller R, Keller A (2022)

Nucleic Acids ResDOI: 10.1093/nar/gkac298

Screening of Natural Products and Small Molecules Uncovers Novel Coronavirus 1a/1b Frameshifting Inhibitors with Antiviral Properties

Kibe A, Elgaher W, Rand U, Zimmer M, Kany A, Hermann J, Müller R, Cicin-Sain L, Hirsch A, Caliskan N (2022)

SSRN JournalDOI: 10.2139/ssrn.4157446

Systematic cross-biospecimen evaluation of DNA extraction kits for long- and short-read multi-metagenomic sequencing studies

Rehner J, Schmartz G, Groeger L, Dastbaz J, Ludwig N, Hannig M, Rupf S, Seitz B, Flockerzi E, Berger T, …, Keller A, Müller R (2022)

Genomics Proteomics BioinformaticsDOI: 10.1016/j.gpb.2022.05.006

Three New Stigmatellin Derivatives Reveal Biosynthetic Insights of Its Side Chain Decoration

Okoth D, Hug J, Garcia R, Müller R (2022)

Molecules (Basel, Switzerland) 27 (14)DOI: 10.3390/molecules27144656

Corallopyronin A: antimicrobial discovery to preclinical development

Krome A, Becker T, Kehraus S, Schiefer A, Gütschow M, Chaverra-Muñoz L, Hüttel S, Jansen R, Stadler M, Ehrens A, …, Wagner K, König G (2022)

Nat. Prod. Rep.DOI: 10.1039/d2np00012a

Corallococcus soli sp. Nov., a Soil Myxobacterium Isolated from Subtropical Climate, Chalus County, Iran, and Its Potential to Produce Secondary Metabolites

Babadi Z, Garcia R, Ebrahimipour G, Risdian C, Kämpfer P, Jarek M, Müller R, Wink J (2022)

Microorganisms 10 (7)DOI: 10.3390/microorganisms10071262

An Outer Membrane Vesicle-Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability

Richter R, Kamal M, Koch M, Niebuur B, Huber A, Goes A, Volz C, Vergalli J, Kraus T, Müller R, …, Pagès J, Lehr C (2022)

Advanced healthcare materials 11 (5)DOI: 10.1002/adhm.202101180

Transferring Microclusters of P. aeruginosa Biofilms to the Air-Liquid Interface of Bronchial Epithelial Cells for Repeated Deposition of Aerosolized Tobramycin

Horstmann J, Laric A, Boese A, Yildiz D, Röhrig T, Empting M, Frank N, Krug D, Müller R, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2022)

ACS infectious diseases 8 (1): 137-149DOI: 10.1021/acsinfecdis.1c00444

Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi

Kirsch S, Haeckl F, Müller R (2022)

Nat. Prod. Rep.DOI: 10.1039/d1np00067e

Regio- and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives

Müller R, Hofer W, Oueis E, Abou Fayad A, Deschner F, Andreas A, Carvalho L, Hüttel S, Bernecker S, Pätzold L, …, Held J, Herrmann J (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202202816

Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa

Kaya C, Walter I, Alhayek A, Shafiei R, Jézéquel G, Andreas A, Konstantinovic J, Schönauer E, Sikandar A, Haupenthal J, …, Hartmann R, Hirsch A (2022)

ACS Infect. Dis.DOI: 10.1021/acsinfecdis.1c00628

Induction of Liver Size Reduction in Zebrafish Larvae by the Emerging Synthetic Cannabinoid 4F-MDMB-BINACA and Its Impact on Drug Metabolism

Park Y, Dahlem C, Meyer M, Kiemer A, Müller R, Herrmann J (2022)

Molecules (Basel, Switzerland) 27 (4)DOI: 10.3390/molecules27041290

N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases

Kaya C, Konstantinovic J, Kany A, Andreas A, Kramer J, Brunst S, Weizel L, Rotter M, Frank D, Yahiaoui S, …, Wichelhaus T, Hirsch A (2022)

Journal of medicinal chemistry 65 (5): 3913-3922DOI: 10.1021/acs.jmedchem.1c01755

Myxobacteria of the Cystobacterineae Suborder Are Producers of New Vitamin K2 Derived Myxoquinones

Panter F, Popoff A, Garcia R, Krug D, Müller R (2022)

Microorganisms 10 (3)DOI: 10.3390/microorganisms10030534

PLSDB: advancing a comprehensive database of bacterial plasmids

Schmartz G, Hartung A, Hirsch P, Kern F, Fehlmann T, Müller R, Keller A (2022)

Nucleic Acids Res 50 (D1): 273-DOI: 10.1093/nar/gkab1111

Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part

Megahed S, Rasheed S, Herrmann J, El-Hossary E, El-Shabrawy Y, Abadi A, Engel M, Müller R, Abdel-Halim M, Hamed M (2022)

Bioorg Med Chem Lett 59DOI: 10.1016/j.bmcl.2022.128531

New Deoxyenhygrolides from Plesiocystis pacifica Provide Insights into Butenolide Core Biosynthesis

Hug J, Kjaerulff L, Garcia R, Müller R (2022)

Marine drugs 20 (1)DOI: 10.3390/md20010072

Sandacrabins - Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium

Bader C, Panter F, Garcia R, Tchesnokov E, Haid S, Walt C, Spröer C, Kiefer A, Götte M, Overmann J, Pietschmann T, Müller R (2022)

Chem. Eur. J. 28 (10)DOI: 10.1002/chem.202104484

Biotechnological production optimization of argyrins - a potent immunomodulatory natural product class

Pogorevc D, Müller R (2022)

Microbial Biotechnology 15 (1): 353-369DOI: 10.1111/1751-7915.13959

2021

Towards the sustainable discovery and development of new antibiotics

Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo P, Glaser P, Aigle B, Bode H, …, Moser H, Müller R (2021)

Nature reviews. Chemistry 5 (10): 726-749DOI: 10.1038/s41570-021-00313-1

Targeting the energy-coupling factor (ECF) transporters: identification of new tool compounds

Diamanti E, Setyawati I, Bousis S, Souza P, mojas l, Swier l, Haupenthal J, Gibson P, Volz C, stanek w, …, slotboom d, Hirsch A (2021)

ChemRxivDOI: 10.26434/chemrxiv-2021-xq08b-v2

Genome-Guided Discovery of the First Myxobacterial Biarylitide Myxarylin Reveals Distinct C-N Biaryl Crosslinking in RiPP Biosynthesis

Hug J, Frank N, Walt C, Šenica P, Panter F, Müller R (2021)

Molecules 26 (24)DOI: 10.3390/molecules26247483

Structure of Escherichia coli cytochrome bd-II type oxidase with bound aurachin D

Grauel A, Kägi J, Rasmussen T, Makarchuk I, Oppermann S, Moumbock A, Wohlwend D, Müller R, Melin F, Günther S, …, Böttcher B, Friedrich T (2021)

Nat Commun 12 (1)DOI: 10.1038/s41467-021-26835-2

Structure and Biosynthesis of Myxofacyclines: Unique Myxobacterial Polyketides Featuring Varing and Rare Heterocycles *

Popoff A, Hug J, Walesch S, Garcia R, Keller L, Müller R (2021)

Chem. Eur. J. 27 (67): 16654-16661DOI: 10.1002/chem.202103095

The natural product vioprolide A exerts anti-inflammatory actions through inhibition of its cellular target NOP14 and downregulation of importin-dependent NF-ĸB p65 nuclear translocation

Burgers L, Luong B, Li Y, Fabritius M, Michalakis S, Reichel C, Müller R, Fürst R (2021)

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 144DOI: 10.1016/j.biopha.2021.112255

Distinct Patterns of Blood Cytokines Beyond a Cytokine Storm Predict Mortality in COVID-19

Herr C, Mang S, Mozafari B, Guenther K, Speer T, Seibert M, Srikakulam S, Beisswenger C, Ritzmann F, Keller A, …, Lepper P, Bals R (2021)

Journal of inflammation research 14: 4651-4667DOI: 10.2147/JIR.S320685

Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Treatment of Dengue Infections Applied to the Broad Spectrum Antiviral Soraphen A

Rox K, Heyner M, Krull J, Harmrolfs K, Rinne V, Hokkanen J, Perez Vilaro G, Díez J, Müller R, Kröger A, Sugiyama Y, Brönstrup M (2021)

ACS Pharmacol. Transl. Sci.DOI: 10.1021/acsptsci.1c00078

Expanding the Myxochelin Natural Product Family by Nicotinic Acid Containing Congeners

Frank N, Széles M, Akone S, Rasheed S, Hüttel S, Frewert S, Hamed M, Herrmann J, Schuler S, Hirsch A, Müller R (2021)

Molecules 26 (16)DOI: 10.3390/molecules26164929

Improved broad-spectrum antibiotics against Gram-negative pathogens via darobactin biosynthetic pathway engineering

Groß S, Panter F, Pogorevc D, Seyfert C, Deckarm S, Bader C, Herrmann J, Müller R (2021)

Chem. Sci. 12 (35): 11882-11893DOI: 10.1039/d1sc02725e

Sesbanimide R, a Novel Cytotoxic Polyketide Produced by Magnetotactic Bacteria

Awal R, Haack P, Bader C, Riese C, Schüler D, Müller R (2021)

mBio 12 (3)DOI: 10.1128/mBio.00591-21

Zebrafish: An Attractive Model to Study Staphylococcus aureus Infection and Its Use as a Drug Discovery Tool

Rasheed S, Fries F, Müller R, Herrmann J (2021)

Pharmaceuticals 14 (6)DOI: 10.3390/ph14060594

Structure and biosynthesis of sorangipyranone - a new γ-dihydropyrone from the myxobacterial strain MSr12020

Okoth D, Hug J, Mándi A, Kurtán T, Garcia R, Müller R (2021)

Journal of Industrial Microbiology & Biotechnology 48 (3-4)DOI: 10.1093/jimb/kuab029

Phosphonate as a Stable Zinc‐Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH) (ChemMedChem 8/2021)

Voos K, Schönauer E, Alhayek A, Haupenthal J, Andreas A, Müller R, Hartmann R, Brandstetter H, Hirsch A, Ducho C (2021)

ChemMedChem 16 (8): 1198-1198DOI: 10.1002/cmdc.202100229

miRMaster 2.0: multi-species non-coding RNA sequencing analyses at scale

Fehlmann T, Kern F, Laham O, Backes C, Solomon J, Hirsch P, Volz C, Müller R, Keller A (2021)

Nucleic Acids ResDOI: 10.1093/nar/gkab268

Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity

Ropponen H, Bader C, Diamanti E, Illarionov B, Rottmann M, Fischer M, Witschel M, Müller R, Hirsch A (2021)

ChemMedChem 16 (13): 2089-2093DOI: 10.1002/cmdc.202100067

Synergizing the potential of bacterial genomics and metabolomics to find novel antibiotics

Panter F, Bader C, Müller R (2021)

Chem. Sci. 12 (17): 5994-6010DOI: 10.1039/d0sc06919a

Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection

Mamareli P, Kruse F, Lu C, Guderian M, Floess S, Rox K, Allan D, Carlyle J, Brönstrup M, Müller R, …, Sparwasser T, Lochner M (2021)

Mucosal Immunol. 14 (1): 164-176DOI: 10.1038/s41385-020-0285-7

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis

Almeida L, Dhillon-LaBrooy A, Castro C, Adossa N, Carriche G, Guderian M, Lippens S, Dennerlein S, Hesse C, Lambrecht B, …, Moita L, Sparwasser T (2021)

Immunity 54 (1): 68-83DOI: 10.1016/j.immuni.2020.11.001

In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis

Groß S, Schnell B, Haack P, Auerbach D, Müller R (2021)

Nat Commun 12 (1)DOI: 10.1038/s41467-021-21848-3

The Sandarazols are Cryptic and Structurally Unique Plasmid-Encoded Toxins from a Rare Myxobacterium*

Panter F, Bader C, Müller R (2021)

Angewandte Chemie (International ed. in English) 60 (15): 8081-8088DOI: 10.1002/anie.202014671

Phosphonate as Stable Zinc-binding Group for Inhibitors of Clostridial Collagenase H (ColH) as Pathoblocker Agents

Voos K, Schönauer E, Alhayek A, Haupenthal J, Andreas A, Müller R, Hartmann R, Brandstetter H, Hirsch A, Ducho C (2021)

ChemMedChemDOI: 10.1002/cmdc.202000994

Expanding the Scope of Detectable Microbial Natural Products by Complementary Analytical Methods and Cultivation Systems

Bader C, Haack P, Panter F, Krug D, Müller R (2021)

Journal of natural products 84 (2): 268-277DOI: 10.1021/acs.jnatprod.0c00942

Kibdelosporangium persicum sp. nov., a new member of the Actinomycetes from a hot desert in Iran

Safaei N, Nouioui I, Mast Y, Zaburannyi N, Rohde M, Schumann P, Müller R, Wink J (2021)

Int. J. Syst. Evol. Microbiol. 71 (2)DOI: 10.1099/ijsem.0.004625

2020

Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics

Grandclaudon C, Birudukota N, Elgaher W, Jumde R, Yahiaoui S, Arisetti N, Hennessen F, Hüttel S, Stadler M, Herrmann J, …, Hirsch A, Brönstrup M (2020)

European journal of medicinal chemistry 188DOI: 10.1016/j.ejmech.2019.112005

Characterization of bromelain indicates a molar excess of inhibitor vs. enzyme molecules, a Jacalin-like lectin and Maillard reaction products

Gross P, Seelert H, Meiser P, Müller R (2020)

Journal of pharmaceutical and biomedical analysis 181DOI: 10.1016/j.jpba.2019.113075

Synthetic and Biological Studies on New Urea and Triazole Containing Cystobactamid Derivatives

Planke T, Cirnski K, Herrmann J, Müller R, Kirschning A (2020)

Chem. Eur. J. 26 (19): 4289-4296DOI: 10.1002/chem.201904073

The glucocorticoid-induced leucine zipper mediates statin-induced muscle damage

Hoppstädter J, Valbuena Perez J, Linnenberger R, Dahlem C, Legroux T, Hecksteden A, Tse W, Flamini S, Andreas A, Herrmann J, …, Bruscoli S, Kiemer A (2020)

FASEB j. 34 (3): 4684-4701DOI: 10.1096/fj.201902557RRR

Myxobacteria-Derived Outer Membrane Vesicles: Potential Applicability Against Intracellular Infections

Goes A, Lapuhs P, Kuhn T, Schulz E, Richter R, Panter F, Dahlem C, Koch M, Garcia R, Kiemer A, Müller R, Fuhrmann G (2020)

Cells 9 (1)DOI: 10.3390/cells9010194

Toxicokinetics and toxicodynamics of the fentanyl homologs cyclopropanoyl-1-benzyl-4´-fluoro-4-anilinopiperidine and furanoyl-1-benzyl-4-anilinopiperidine

Gampfer T, Wagmann L, Park Y, Cannaert A, Herrmann J, Fischmann S, Westphal F, Müller R, Stove C, Meyer M (2020)

Arch. Toxicol. 94 (6): 2009-2025DOI: 10.1007/s00204-020-02726-1

The ROK like protein of Myxococcus xanthus DK1622 acts as a pleiotropic transcriptional regulator for secondary metabolism

Izzat S, Rachid S, Ajdidi A, El-Nakady Y, Liu X, Ye B, Müller R (2020)

J. Biotechnol. 311: 25-34DOI: 10.1016/j.jbiotec.2020.02.005

Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics

Elgaher W, Hamed M, Baumann S, Herrmann J, Siebenbürger L, Krull J, Cirnski K, Kirschning A, Brönstrup M, Müller R, Hartmann R (2020)

Chem. Eur. J. 26 (32): 7219-7225DOI: 10.1002/chem.202000117

Dual-Seq reveals genome and transcriptome of Caedibacter taeniospiralis, obligate endosymbiont of Paramecium

Pirritano M, Zaburannyi N, Grosser K, Gasparoni G, Müller R, Simon M, Schrallhammer M (2020)

Sci. Rep. 10 (1)DOI: 10.1038/s41598-020-65894-1

Thioholgamide A, a New Anti-Proliferative Anti-Tumor Agent, Modulates Macrophage Polarization and Metabolism

Dahlem C, Siow W, Lopatniuk M, Tse W, Kessler S, Kirsch S, Hoppstädter J, Vollmar A, Müller R, Luzhetskyy A, Bartel K, Kiemer A (2020)

Cancers 12 (5)DOI: 10.3390/cancers12051288

Human microbial metabolite mimicry as a strategy to expand the chemical space of potential drugs

Li H, Ranhotra H, Mani S, Dvorák Z, Sokol H, Müller R (2020)

Drug Discov. Today 25 (9): 1575-1579DOI: 10.1016/j.drudis.2020.06.007

ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli

Wallenstein A, Rehm N, Brinkmann M, Selle M, Bossuet-Greif N, Sauer D, Bunk B, Spröer C, Wami H, Homburg S, …, Müller R, Dobrindt U (2020)

mSphere 5 (4)DOI: 10.1128/mSphere.00591-20

Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin

Hennessen F, Miethke M, Zaburannyi N, Loose M, Lukežic T, Bernecker S, Hüttel S, Jansen R, Schmiedel J, Fritzenwanker M, …, Herrmann J, Müller R (2020)

Antibiotics 9 (9)DOI: 10.3390/antibiotics9090619

How to Study the Metabolism of New Psychoactive Substances for the Purpose of Toxicological Screenings-A Follow-Up Study Comparing Pooled Human Liver S9, HepaRG Cells, and Zebrafish Larvae

Wagmann L, Frankenfeld F, Park Y, Herrmann J, Fischmann S, Westphal F, Müller R, Flockerzi V, Meyer M (2020)

Frontiers in chemistry 8DOI: 10.3389/fchem.2020.00539

Natural Products Impacting DNA Methyltransferases and Histone Deacetylases

Akone S, Ntie-Kang F, Stuhldreier F, Ewonkem M, Noah A, Mouelle S, Müller R (2020)

Frontiers in pharmacology 11DOI: 10.3389/fphar.2020.00992

Heterologous expression of the atypical tetracycline chelocardin reveals the full set of genes required for its biosynthesis

Lukežic T, Pikl Š, Zaburannyi N, Remškar M, Petkovic H, Müller R (2020)

Microb. Cell Fact. 19 (1)DOI: 10.1186/s12934-020-01495-x

Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections

Schiefer A, Hübner M, Krome A, Lämmer C, Ehrens A, Aden T, Koschel M, Neufeld H, Chaverra-Muñoz L, Jansen R, …, Pfarr K, Hoerauf A (2020)

PLoS Negl. Trop. Dis. 14 (12)DOI: 10.1371/journal.pntd.0008930

Leben und Überleben im Boden: Myxococcus xanthus ist Mikrobe des Jahres 2020

Volz C, Krug D, Müller R (2020)

Biol. Unserer Zeit 50 (6): 424-432DOI: 10.1002/biuz.202010721

The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase

Lilic M, Chen J, Boyaci H, Braffman N, Hubin E, Herrmann J, Müller R, Mooney R, Landick R, Darst S, Campbell E (2020)

Proc. Natl. Acad. Sci. U.S.A.DOI: 10.1073/pnas.2013706117

Supercritical Fluid Extraction Enhances Discovery of Secondary Metabolites from Myxobacteria

Bader C, Neuber M, Panter F, Krug D, Müller R (2020)

Analytical chemistry 92 (23): 15403-15411DOI: 10.1021/acs.analchem.0c02995

An ambruticin-sensing complex modulates Myxococcus xanthus development and mediates myxobacterial interspecies communication

Marcos-Torres F, Volz C, Müller R (2020)

Nat Commun 11 (1)DOI: 10.1038/s41467-020-19384-7

Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry

Cirnski K, Coetzee J, Herrmann J, Müller R (2020)

Journal of visualized experiments : JoVE (164)DOI: 10.3791/61703

Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model

Park Y, Meyer M, Müller R, Herrmann J (2020)

Molecules 25 (19)DOI: 10.3390/molecules25194474

2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene-Nucleoside

Okoth D, Hug J, Garcia R, Spröer C, Overmann J, Müller R (2020)

Molecules (Basel, Switzerland) 25 (11)DOI: 10.3390/molecules25112676

Biosynthesis of Cittilins, Unusual Ribosomally Synthesized and Post-translationally Modified Peptides from Myxococcus xanthus

Hug J, Dastbaz J, Adam S, Revermann O, Koehnke J, Krug D, Müller R (2020)

ACS chemical biology 15 (8): 2221-2231DOI: 10.1021/acschembio.0c00430

PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus

Anversa Dimer F, Souza Carvalho-Wodarz C, Goes A, Cirnski K, Herrmann J, Schmitt V, Pätzold L, Abed N, Rossi C, Bischoff M, …, Müller R, Lehr C (2020)

Nanomedicine : nanotechnology, biology, and medicine 24DOI: 10.1016/j.nano.2019.102125

Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections

Ho D, Murgia X, Rossi C, Christmann R, Hüfner de Mello Martins A, Koch M, Andreas A, Herrmann J, Müller R, Empting M, …, Couvreur P, Lehr C (2020)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202001407

Protein‐Templated Hit Identification via an Ugi Four‐Component Reaction

Mancini F, Unver M, Elgaher W, Jumde V, Alhayek A, Lukat P, Herrmann J, Witte M, Köck M, Blankenfeldt W, Müller R, Hirsch A (2020)

Chem. Eur. J.DOI: 10.1002/chem.202002250

Synthesis and Biological Evaluation of Novel 2-Substituted Analogues of (–)-Pentenomycin I

Zisopoulou S, Bousis S, Haupenthal J, Herrmann J, Müller R, Hirsch A, Komiotis D, Gallos J, Stathakis C (2020)

Synlett 31 (05): 475-481DOI: 10.1055/s-0039-1690772

N -Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases

Konstantinovic J, Yahiaoui S, Alhayek A, Haupenthal J, Schönauer E, Andreas A, Kany A, Müller R, Koehnke J, Berger F, …, Brandstetter H, Hirsch A (2020)

J. Med. Chem. 63 (15): 8359-8368DOI: 10.1021/acs.jmedchem.0c00584

Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy

Testolin G, Cirnski K, Rox K, Prochnow H, Fetz V, Grandclaudon C, Mollner T, Baiyoumy A, Ritter A, Leitner C, …, Müller R, Brönstrup M (2020)

Chemical Science 11 (5): 1316-1334DOI: 10.1039/C9SC04769G

Bacteria as genetically programmable producers of bioactive natural products

Hug J, Krug D, Müller R (2020)

Nat. rev. chem. 4 (4): 172-193DOI: 10.1038/s41570-020-0176-1

Host Development for Heterologous Expression and Biosynthetic Studies of Myxobacterial Natural Products

Hug J, Müller R (2020)

In press: 149-216DOI: 10.1016/B978-0-12-409547-2.14818-8

Myxobakterielle Naturstofffabriken

Krug D, Garcia R, Müller R (2020)

Biospektrum 26 (1): 32-36DOI: 10.1007/s12268-020-1334-1

Dual-function chromogenic screening-based CRISPR/Cas9 genome editing system for actinomycetes

Wang Q, Xie F, Tong Y, Habisch R, Yang B, Zhang L, Müller R, Fu C (2020)

Applied Microbiology and Biotechnology 104 (1): 225-239DOI: 10.1007/s00253-019-10223-4

In depth natural product discovery - Myxobacterial strains that provided multiple secondary metabolites

Bader C, Panter F, Müller R (2020)

Biotechnol Adv 39DOI: 10.1016/j.biotechadv.2019.107480

2019

Ribosome-targeting antibiotics impair T cell effector function and ameliorate autoimmunity by blocking mitochondrial protein synthesis

Almeida L, Dhillon-LaBrooy A, Castro C, Ayele N, Bartel J, Carriche G, Guderian M, Lippens S, Dennerlein S, Hesse C, …, Moita L, Sparwasser T (2019)

Book 97DOI: 10.1101/832956

Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy

Pfitzer L, Moser C, Gegenfurtner F, Arner A, Foerster F, Atzberger C, Zisis T, Kubisch-Dohmen R, Busse J, Smith R, …, Vollmar A, Zahler S (2019)

Cell Death Dis. 10 (4)DOI: 10.1038/s41419-019-1546-9

Synthesis of New Cyclomarin Derivatives and Their Biological Evaluation towards Mycobacterium Tuberculosis and Plasmodium Falciparum

Kiefer A, Bader C, Held J, Esser A, Rybniker J, Empting M, Müller R, Kazmaier U (2019)

Chem. Eur. J. 25 (37): 8894-8902DOI: 10.1002/chem.201901640

Corrigendum to biocompatible bacteria-derived vesicles show inherent antimicrobial activity (Journal of Controlled Release (2018) 290 (46–55), (S0168365918305698) (10.1016/j.jconrel.2018.09.030))

Schulz E, Goes A, Garcia R, Panter F, Koch M, Müller R, Fuhrmann K, Fuhrmann G (2019)

Journal of Controlled Release 293: 155-157DOI: 10.1016/j.jconrel.2018.11.027

Chemical synthesis of tripeptide thioesters for the biotechnological incorporation into the myxobacterial secondary metabolite argyrin via mutasynthesis

Siebert D, Sommer R, Pogorevc D, Hoffmann M, Wenzel S, Müller R, Titz A (2019)

Beilstein journal of organic chemistry 15: 2922-2929DOI: 10.3762/bjoc.15.286

Clinical Resistome Screening of 1,110 Escherichia coli Isolates Efficiently Recovers Diagnostically Relevant Antibiotic Resistance Biomarkers and Potential Novel Resistance Mechanisms

Volz C, Ramoni J, Beisken S, Galata V, Keller A, Plum A, Posch A, Müller R (2019)

Front. Microbiol. 10DOI: 10.3389/fmicb.2019.01671

Polyunsaturated fatty acid production by Yarrowia lipolytica employing designed myxobacterial PUFA synthases

Gemperlein K, Dietrich D, Kohlstedt M, Zipf G, Bernauer H, Wittmann C, Wenzel S, Müller R (2019)

Nat. Commun. 10 (1)DOI: 10.1038/s41467-019-12025-8

Production of a Dibrominated Aromatic Secondary Metabolite by a Planctomycete Implies Complex Interaction with a Macroalgal Host

Panter F, Garcia R, Thewes A, Zaburannyi N, Bunk B, Overmann J, Gutierrez M, Krug D, Müller R (2019)

ACS Chem. Biol. 14 (accepted // 12): 2713-2719DOI: 10.1021/acschembio.9b00641

Production optimization and biosynthesis revision of corallopyronin A, a potent anti-filarial antibiotic

Pogorevc D, Panter F, Schillinger C, Jansen R, Wenzel S, Müller R (2019)

Metab. Eng. 55: 201-211DOI: 10.1016/j.ymben.2019.07.010

Two Biosynthetic Pathways in Jahnella thaxteri for Thaxteramides, Distinct Types of Lipopeptides

Oueis E, Klefisch T, Zaburannyi N, Garcia R, Plaza A, Müller R (2019)

Org. Lett. 21 (14): 5407-5412DOI: 10.1021/acs.orglett.9b01524

Dedication: Heinz Floss and Christopher Walsh-pioneers in natural product chemical biology

Müller R, Wright G (2019)

Journal of Industrial Microbiology & Biotechnology 46 (3-4): 251-255DOI: 10.1007/s10295-019-02139-9

Engineering Atypical Tetracycline Formation in Amycolatopsis sulphurea for the Production of Modified Chelocardin Antibiotics

Lukežic T, Fayad A, Bader C, Harmrolfs K, Bartuli J, Groß S, Lešnik U, Hennessen F, Herrmann J, Pikl Š, Petkovic H, Müller R (2019)

ACS Chem. Biol. 14 (3): 468-477DOI: 10.1021/acschembio.8b01125

Armeniaspirol Antibiotic Biosynthesis: Chlorination and Oxidative Dechlorination Steps Affording Spiro4.4non-8-ene

Fu C, Xie F, Hoffmann J, Wang Q, Bauer A, Brönstrup M, Mahmud T, Müller R (2019)

ChemBioChem 20 (6): 764-769DOI: 10.1002/cbic.201800791

Heterologous expression of bacterial natural product biosynthetic pathways

Huo L, Hug J, Fu C, Bian X, Zhang Y, Müller R (2019)

Nat. Prod. Rep. 36: 1412-1436DOI: 10.1039/C8NP00091C

Genome mining reveals uncommon alkylpyrones as type III PKS products from myxobacteria

Hug J, Panter F, Krug D, Müller R (2019)

J. Ind. Microbiol. Biotechnol. 46 (3-4): 319-334DOI: 10.1007/s10295-018-2105-6

Class I Methyltransferase VioH Catalyzes Unusual S-Adenosyl-l-methionine Cyclization Leading to 4-Methylazetidinecarboxylic Acid Formation during Vioprolide Biosynthesis

Yan F, Müller R (2019)

ACS Chem. Biol. 14 (1): 99-105DOI: 10.1021/acschembio.8b00958

Novel Methoxymethacrylate Natural Products Uncovered by Statistics-Based Mining of the Myxococcus fulvus Secondary Metabolome

Panter F, Krug D, Müller R (2019)

ACS Chem. Biol. 14 (1): 88-98DOI: 10.1021/acschembio.8b00948

2018

The Alkylquinolone Repertoire of Pseudomonas aeruginosa is Linked to Structural Flexibility of the FabH-like 2-Heptyl-3-hydroxy-4(1H)-quinolone (PQS) Biosynthesis Enzyme PqsBC

Witzgall F, Depke T, Hoffmann M, Empting M, Brönstrup M, Müller R, Blankenfeldt W (2018)

Chembiochem : a European journal of chemical biology 19 (14): 1531-1544DOI: 10.1002/cbic.201800153

Aspherical and Spherical InvA497-Functionalized Nanocarriers for Intracellular Delivery of Anti-Infective Agents

Castoldi A, Empting M, Rossi C, Mayr K, Dersch P, Hartmann R, Müller R, Gordon S, Lehr C (2018)

Pharm Res 36 (1)DOI: 10.1007/s11095-018-2521-3

Iterative Methylations Resulting in the Biosynthesis of the t-Butyl Group Catalyzed by a B12-Dependent Radical SAM Enzyme in Cystobactamid Biosynthesis

Wang Y, Schnell B, Müller R, Begley T (2018)

Methods in enzymology 606: 199-216DOI: 10.1016/bs.mie.2018.05.018

Adaptation of a Bacterial Multidrug Resistance System Revealed by the Structure and Function of AlbA

Sikandar A, Cirnski K, Testolin G, Volz C, Brönstrup M, Kalinina O, Müller R, Koehnke J (2018)

J. Am. Chem. Soc. 140 (48): 16641-16649DOI: 10.1021/jacs.8b08895

Characterization of an Unusual Glycerate Esterification Process in Vioprolide Biosynthesis

Auerbach D, Yan F, Zhang Y, Müller R (2018)

ACS Chem. Biol. 13 (11): 3123-3130DOI: 10.1021/acschembio.8b00826

Biocompatible bacteria-derived vesicles show inherent antimicrobial activity

Schulz E, Goes A, Garcia R, Panter F, Koch M, Müller R, Fuhrmann K, Fuhrmann G (2018)

Journal of Controlled Release 290: 46-55DOI: 10.1016/j.jconrel.2018.09.030

A polyphasic approach leads to seven new species of the cellulose-decomposing genus Sorangium, Sorangium ambruticinum sp. nov., Sorangium arenae sp. nov., Sorangium bulgaricum sp. nov., Sorangium dawidii sp. nov., Sorangium kenyense sp. nov., Sorangium orientale sp. nov. and Sorangium reichenbachii sp. nov

Mohr K, Wolf C, Nübel U, Szafranska A, Steglich M, Hennessen F, Gemperlein K, Kämpfer P, Martin K, Müller R, Wink J (2018)

Int. J. Syst. Evol. Microbiol. 68 (11)DOI: 10.1099/ijsem.0.003034

Activation of the NLRP3 inflammasome by hyaboron, a new asymmetric boron-containing macrodiolide from the Myxobacterium Hyalangium minutum

Surup F, Chauhan D, Niggemann J, Bartok E, Herrmann J, Koeck M, Zander W, Stadler M, Hornung V, Müller R (2018)

ACS Chem. Biol. 13 (10): 2981-2988DOI: 10.1021/acschembio.8b00659

Metabolic and Biosynthetic Diversity in Marine Myxobacteria

Gemperlein K, Zaburannyi N, Garcia R, La Clair J, Müller R (2018)

Mar. Drugs 16 (9)DOI: 10.3390/md16090314

Future Directions of Marine Myxobacterial Natural Product Discovery Inferred from Metagenomics

Garcia R, La Clair J, Müller R (2018)

Mar. Drugs 16 (9)DOI: 10.3390/md16090303

Simulacricoccus ruber gen. nov., sp. nov., a microaerotolerant, non-fruiting, myxospore-forming soil myxobacterium and emended description of the family Myxococcaceae

Garcia R, Müller R (2018)

Int. J. Syst. Evol. Microbiol. 68 (10): 3101-3110DOI: 10.1099/ijsem.0.002936

Structure, Total Synthesis, and Biosynthesis of Chloromyxamides: Myxobacterial Tetrapeptides Featuring an Uncommon 6-Chloromethyl-5-methoxypipecolic Acid Building Block

Gorges J, Panter F, Kjaerulff L, Hoffmann T, Kazmaier U, Müller R (2018)

Angew. Chem. Int. Ed. Engl. 57 (43): 14270-14275DOI: 10.1002/anie.201808028

Concepts and Methods to Access Novel Antibiotics from Actinomycetes

Hug J, Bader C, Remškar M, Cirnski K, Müller R (2018)

Antibiotics 7 (2)DOI: 10.3390/antibiotics7020044

Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria

Panter F, Krug D, Baumann S, Müller R (2018)

Chem. Sci. 9 (21): 4898-4908DOI: 10.1039/C8SC01325J

Biosynthesis and Heterologous Production of Vioprolides: Rational Biosynthetic Engineering and Unprecedented 4-Methylazetidinecarboxylic Acid Formation

Yan F, Auerbach D, Chai Y, Keller L, Tu Q, Hüttel S, Glemser A, Grab H, Bach T, Zhang Y, Müller R (2018)

Angew. Chem. Int. Ed. Engl. 57 (28): 8754-8759DOI: 10.1002/anie.201802479

Octapeptins: lipopeptide antibiotics against multidrug-resistant superbugs

Abou Fayad A, Herrmann J, Müller R (2018)

Cell Chem. Biol. 25 (4): 351-353DOI: 10.1016/j.chembiol.2018.04.003

Nannocystis konarekensis sp. nov., a novel myxobacterium from an Iranian desert

Mohr K, Moradi A, Glaeser S, Kämpfer P, Gemperlein K, Nübel U, Schumann P, Müller R, Wink J (2018)

Int. J. Syst. Evol. Microbiol. 68 (3): 721-729DOI: 10.1099/ijsem.0.002569

Biosynthesis of the Klebsiella oxytoca Pathogenicity Factor Tilivalline: Heterologous Expression, in Vitro Biosynthesis, and Inhibitor Development

Tesmar A, Hoffmann M, Abou Fayad A, Hüttel S, Schmitt V, Herrmann J, Müller R (2018)

ACS Chem. Biol. 13 (3): 812-819DOI: 10.1021/acschembio.7b00990

Crocadepsins-Depsipeptides from the Myxobacterium Chondromyces crocatus Found by a Genome Mining Approach

Surup F, Viehrig K, Rachid S, Plaza A, Maurer C, Hartmann R, Müller R (2018)

ACS Chem. Biol. 13 (1): 267-272DOI: 10.1021/acschembio.7b00900

Homospermidine Lipids: A compound class specifically formed during fruiting body formation of Myxococcus xanthus DK1622

Hoffmann M, Auerbach D, Panter F, Hoffmann T, Dorrestein P, Müller R (2018)

ACS Chem. Biol. 13 (1): 273-280DOI: 10.1021/acschembio.7b00816

Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria

Hoffmann T, Krug D, Bozkurt N, Duddela S, Jansen R, Garcia R, Gerth K, Steinmetz H, Müller R (2018)

Nat. Commun. 9 (1)DOI: 10.1038/s41467-018-03184-1

Production of myxopyronin and of its derivatives

Sucipto H, Sahner J, Wenzel S, Groh M, Hartmann R, Müller R (2018)

Patent (EP 2 994 535 B1)

2017

AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus

Bock T, Luxenburger E, Hoffmann J, Schütza V, Feiler C, Müller R, Blankenfeldt W (2017)

Angewandte Chemie (International ed. in English) 56 (33): 9986-9989DOI: 10.1002/anie.201701992

Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging

Wagner S, Hauck D, Hoffmann M, Sommer R, Joachim I, Müller R, Imberty A, Varrot A, Titz A (2017)

Angewandte Chemie (International ed. in English) 56 (52): 16559-16564DOI: 10.1002/anie.201709368

Novel and revisited approaches in antituberculosis drug discovery

Herrmann J, Rybniker J, Müller R (2017)

Current opinion in biotechnology 48: 94-101DOI: 10.1016/j.copbio.2017.03.023

Synthetic biology approaches to establish a heterologous production system for coronatines

Gemperlein K, Hoffmann M, Huo L, Pilak P, Petzke L, Müller R, Wenzel S (2017)

Metab. Eng. 44: 213-222DOI: 10.1016/j.ymben.2017.09.009

Heterologous production of myxobacterial α-pyrone antibiotics in Myxococcus xanthus

Sucipto H, Pogorevc D, Luxenburger E, Wenzel S, Müller R (2017)

Metab. Eng. 44: 160-170DOI: 10.1016/j.ymben.2017.10.004

Thioholgamides: Thioamide-Containing Cytotoxic RiPP Natural Products

Kjaerulff L, Sikandar A, Zaburannyi N, Adam S, Herrmann J, Koehnke J, Müller R (2017)

ACS Chem. Biol. 12 (11): 2837-2841DOI: 10.1021/acschembio.7b00676

Linoleic and palmitoleic acid block streptokinase-mediated plasminogen activation and reduce severity of invasive group A streptococcal infection

Rox K, Jansen R, Loof T, Gillen C, Bernecker S, Walker M, Chhatwal G, Müller R (2017)

Scientific Reports 7 (1)DOI: 10.1038/s41598-017-11276-z

Total Biosynthesis of the Pyrrolo4,2benzodiazepine Scaffold Tomaymycin on an In Vitro Reconstituted NRPS System

Tesmar A, Hoffmann M, Pippel J, Fayad A, Dausend-Werner S, Bauer A, Blankenfeldt W, Müller R (2017)

Cell Chem. Biol. 24 (10): 1216-1227DOI: 10.1016/j.chembiol.2017.08.001

Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity

Lukat P, Katsuyama Y, Wenzel S, Binz T, König C, Blankenfeldt W, Brönstrup M, Müller R (2017)

Chem. Sci. 8 (11)DOI: 10.1039/C7SC02622F

Total syntheses of cystobactamids and structural confirmation of cystobactamid 919-2

Trauner D, Cheng B, Müller R (2017)

Angew. Chem. Int. Ed. 56 (26): 7407-7410DOI: 10.1002/anie.201705387

Pyxipyrrolones: Structure elucidation and biosynthesis of cytotoxic myxobacterial metabolites

Kjaerulff L, Raju R, Panter F, Scheid U, Garcia R, Herrmann J, Müller R (2017)

Angew. Chem. Int. Ed. 56 (32): 9614-9618DOI: 10.1002/anie.201704790

The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

Fu C, Sikandar A, Donner J, Zaburannyi N, Herrmann J, Reck M, Wagner-Döbler I, Koehnke J, Müller R (2017)

Nat Commun 8 (1)DOI: 10.1038/s41467-017-01671-5

Vitiosangium cumulatum gen. nov., sp. nov. and Vitiosangium subalbum sp. nov., soil myxobacteria, and emended descriptions of the genera Archangium and Angiococcus, and of the family Cystobacteraceae

Awal R, Garcia R, Gemperlein K, Wink J, Kunwar B, Parajuli N, Müller R (2017)

Int. J. Syst. Evol. Microbiol. 67 (5): 1422-1430DOI: 10.1099/ijsem.0.001829

Disorazoles block group A streptococcal invasion into epithelial cells via interference with the host factor ezrin

Rox K, Rohde M, Chhatwal G, Müller R (2017)

Cell Chem. Biol. 24 (1): 159-170DOI: 10.1016/j.chembiol.2016.12.011

Structure and biosynthesis of crocagins: polycyclic postranslationally modified ribosomal peptides from Chondromyces crocatus

Viehrig K, Surup F, Volz C, Herrmann J, Abou Fayad A, Adam S, Kohnke J, Trauner D, Müller R (2017)

Angew. Chem. (56): 1-5DOI: 10.1002/anie.201612640

Solving the puzzle of the one-carbon loss in ripostatin biosynthesis

Fu C, Auerbach D, Li Y, Scheid U, Luxenburger E, Garcia R, Irschik H, Müller R (2017)

Angew. Chem. Int. Ed. Engl. 56 (8): 2192-2197DOI: 10.1002/anie.201609950

Natural products from myxobacteria: novel metabolites and bioactivities

Herrmann J, Fayad A, Müller R (2017)

Nat. Prod. Rep. 34 (2): 135-160DOI: 10.1039/C6NP00106H

2016

Isolation, Structure Elucidation, Biosynthesis, and Synthesis of Antalid, a Secondary Metabolite from Polyangium species

Tautz T, Hoffmann J, Hoffmann T, Steinmetz H, Washausen P, Kunze B, Huch V, Kitsche A, Reichenbach H, Höfle G, Müller R, Kalesse M (2016)

Org. Lett. 18 (11): 2560-3DOI: 10.1021/acs.orglett.6b00810

Racemicystis persica sp. nov., a novel myxobacterium from Iranian soil

Wink J, Moradi A, Ebrahimipour G, Mohr K, Kämpfer P, Glaeser S, Hennessen F, Gemperlein K, Awal R, Wolf C, Müller R (2016)

International Journal of Systematic and Evolutionary Microbiology epub ahead of printDOI: 10.1099/ijsem.0.001655

Heterologous expression of the plant cysteine protease bromelain and its inhibitor in Pichia pastoris

Luniak N, Meiser P, Burkart S, Müller R (2016)

Biotechnol Progress 33 (1): 54-65DOI: 10.1002/btpr.2405

Strategies for the discovery and development of new antibiotics from natural products: Three case studies

Herrmann J, Lukezic T, Kling A, Baumann S, Hüttel S, Petkovic H, Müller R (2016)

Contribution: 1-25DOI: 10.1007/82_2016_498

Structure and Substrate Recognition of the Bottromycin Maturation Enzyme BotP

Mann G, Huo L, Adam S, Nardone B, Vendome J, Westwood N, Muller R, Koehnke J (2016)

ChemBioChem 17 (23): 2286-2292DOI: 10.1002/cbic.201600406

Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies

Maurer C, Fruth M, Empting M, Avrutina O, Hossmann J, Nadmid S, Gorges J, Herrmann J, Kazmaier U, Dersch P, Muller R, Hartmann R (2016)

Future medicinal chemistry 8 (9): 931-47DOI: 10.4155/fmc-2016-0033

Isolation, structure elucidation, and (bio)synthesis of Haprolid, a cell-type-specific myxobacterial cytotoxin

Steinmetz H, Li J, Fu C, Zaburannyi N, Kunze B, Harmrolfs K, Schmitt V, Herrmann J, Reichenbach H, Hofle G, Kalesse M, Müller R (2016)

Angew. Chem. Int. Ed. Engl. 55 (34): 10113-7DOI: 10.1002/anie.201603288

Predicting the presence of uncommon elements in unknown biomolecules from isotope patterns

Meusel M, Hufsky F, Panter F, Krug D, Müller R, Böcker S (2016)

Anal. Chem. 88: 7556-7566DOI: 10.1021/acs.analchem.6b01015

Room temperature electrocompetent bacterial cells improve DNA transformation and recombineering efficiency

Tu Q, Yin J, Fu J, Herrmann J, Li Y, Yin Y, Stewart A, Müller R, Zhang Y (2016)

Sci. Rep. 6DOI: 10.1038/srep24648

Racemicystis crocea gen. nov., sp. nov., a novel soil myxobacterium in Polyangiaceae

Awal R, Garcia R, Müller R (2016)

Int. J. Syst. Evol. Microbiol. (66)DOI: 10.1099/ijsem.0.001045

RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression

Wang H, Li Z, Jia R, Hou Y, Yin J, Bian X, Li A, Muller R, Stewart A, Fu J, Zhang Y (2016)

Nat. Protoc. 11 (7): 1175-1190DOI: 10.1038/nprot.2016.054

Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering

Tu Q, Herrmann J, Hu S, Raju R, Bian X, Zhang Y, Müller R (2016)

Sci. Rep. 6DOI: 10.1038/srep21066

Genome analysis of the fruiting body forming myxobacterium Chondromyces crocatus reveals high potential for natural product Biosynthesis

Zaburannyi N, Bunk B, Maier J, Overmann J, Müller R (2016)

Appl. Environ. Microbiol. 82 (6): 1945-57DOI: 10.1128/AEM.03011-15

Investigations to the antibacterial mechanism of action of kendomycin

Elnakady Y, Chatterjee I, Bischoff M, Rohde M, Josten M, Sahl H, Herrmann M, Müller R (2016)

PLoS ONE 11 (1): 1-18DOI: 10.1371/journal.pone.0146165

Aetherobacter fasciculatus gen. nov., sp. nov. and Aetherobacter rufus gen. nov., sp. nov., two novel myxobacteria with promising biotechnological applications

Garcia R, Stadler M, Gemperlein K, Müller R (2016)

Int. J. Syst. Evol. Microbiol. 66: 928-938DOI: 10.1099/ijsem.0.000813

Metabolic engineering of Pseudomonas putida for production of docosahexaenoic acid based on a myxobacterial PUFA synthase

Gemperlein K, Zipf G, Bernauer H, Müller R, Wenzel S (2016)

Metab. Eng. 33: 98-108DOI: 10.1016/j.ymben.2015.11.001

2015

Synthetic pathway enzymes for the production of Argyrins

Müller R, Wenzel S, Garcia R (2015)

Patent (US9217169 B2)

Two of a kind-The biosynthetic pathways of chlorotonil and anthracimycin

Jungmann K, Jansen R, Gerth K, Huch V, Krug D, Fenical W, Müller R (2015)

ACS Chem. Biol. 10 (11): 2480-2490DOI: 10.1021/acschembio.5b00523

Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster from Streptomyces albus DSM41398 in Streptomyces coelicolor A3(2)

Yin J, Hoffmann M, Bian X, Tu Q, Yan F, Xia L, Ding X, Stewart A, Müller R, Fu J, Zhang Y (2015)

Sci. Rep. 5DOI: 10.1038/srep15081

Production of the bengamide class of marine natural products in myxobacteria: biosynthesis and structure-activity relationships

Wenzel S, Hoffmann H, Zhang J, Debussche L, Haag-Richter S, Kurz M, Nardi F, Lukat P, Kochems I, Tietgen H, …, Müller R, Brönstrup M (2015)

Angew. Chem. Int. Ed. Engl. 54 (51): 15560-4DOI: 10.1002/anie.201508277

Construction of a new class of tetracycline lead structures with potent antibacterial activity through biosynthetic engineering

Lešnik U, Lukežic T, Podgoršek A, Horvat J, Polak T, Šala M, Jenko B, Harmrolfs K, Ocampo-Sosa A, Martínez-Martínez L, …, Müller R, Petkovic H (2015)

Angew. Chem. Int. Ed. Engl. 54 (13): 3937-3940DOI: 10.1002/anie.201411028

Pinensins: the first antifungal lantibiotics

Mohr K, Volz C, Jansen R, Wray V, Hoffmann J, Bernecker S, Wink J, Gerth K, Stadler M, Müller R (2015)

Angew. Chem. Int. Ed. Engl. 127 (38): 11254-11258DOI: 10.1002/anie.201500927

Cystochromones, unusual chromone-containing polyketides from the myxobacterium Cystobacter sp. MCy9104

Nadmid S, Plaza A, Garcia R, Müller R (2015)

J. Nat. Prod. 78 (8): 2023-8DOI: 10.1021/acs.jnatprod.5b00343

Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome

Keller L, Plaza A, Dubiella C, Groll M, Kaiser M, Müller R (2015)

J. Am. Chem. Soc. 137 (25): 8121-30DOI: 10.1021/jacs.5b03833

Biosynthetic studies of telomycin reveal new lipopeptides with enhanced activity

Fu C, Keller L, Bauer A, Brönstrup M, Froidbise A, Hammann P, Herrmann J, Mondesert G, Kurz M, Schiell M, …, Wink J, Müller R (2015)

J. Am. Chem. Soc. 137 (24): 7692-7705DOI: 10.1021/jacs.5b01794

Targeting DnaN for tuberculosis therapy using novel griselimycins

Kling A, Lukat P, Almeida D, Bauer A, Fontaine E, Sordello S, Zaburannyi N, Herrmann J, Wenzel S, König C, …, Lagrange S, Müller R (2015)

Science 348 (6239): 1106-1112DOI: 10.1126/science.aaa4690

In Vitro reconstitution of α-Pyrone ring formation in myxopyronin biosynthesis

Sucipto H, Sahner J, Prusov E, Wenzel S, Hartmann R, Koehnke J, Müller R (2015)

Chem. Sci. 6: 5076-5085DOI: 10.1039/C5SC01013F

Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety

Bian X, Plaza A, Zhang Y, Müller R (2015)

Chem. Sci. 6 (5): 3154-3160DOI: 10.1039/c5sc00101c

Synthesis and biological evaluation of cystobactamid 507: a bacterial topoisomerase inhibitor from Cystobacter sp

Moreno M, Elgaher W, Herrmann J, Schläger N, Hamed M, Baumann S, Müller R, Hartmann R, Kirschning A (2015)

Synlett 26 (9): 1175-1178DOI: 10.1055/s-0034-1380509

Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo

Bian X, Plaza A, Yan F, Zhang Y, Müller R (2015)

Biotechnol. Bioeng. 112 (7): 1343-53DOI: 10.1002/bit.25560

Advanced mutasynthesis studies on the natural α-pyrone antibiotic myxopyronin from Myxococcus fulvus

Sahner J, Sucipto H, Wenzel S, Groh M, Hartmann R, Müller R (2015)

ChemBioChem 16: 946-953DOI: 10.1002/cbic.201402666

Cystodienoic acid: A new diterpene isolated from the myxobacterium Cystobacter sp.

Raju R, Mohr K, Bernecker S, Herrmann J, Müller R (2015)

J. Antibiot. 68: 473-475DOI: 10.1038/ja.2015.8

Heterologous expression of an orphan NRPS gene cluster from Paenibacillus larvae in Escherichia coli revealed production of sevadicin

Tang Y, Frewert S, Harmrolfs K, Herrmann J, Karmann L, Kazmaier U, Xia L, Zhang Y, Müller R (2015)

J. Biotechnol. 194: 112-114DOI: 10.1016/j.jbiotec.2014.12.008

Aggregicoccus edonensis gen. nov., sp. nov., an unusually aggregating myxobacterium isolated from a soil sample

Sood S, Awal R, Wink J, Mohr K, Rohde M, Stadler M, Kämpfer P, Glaeser S, Schumann P, Garcia R, Müller R (2015)

Int. J. Syst. Evol. Microbiol. 65 (Pt 3): 745-753DOI: 10.1099/ijs.0.061176-0

2014

Cystobactamids: myxobacterial topoisomerase inhibitors exhibiting potent antibacterial activity

Baumann S, Herrmann J, Raju R, Steinmetz H, Mohr K, Hüttel S, Harmrolfs K, Stadler M, Müller R (2014)

Angew. Chem. Int. Ed. 53 (52): 14605-14609DOI: 10.1002/anie.201409964

Nannozinones and Sorazinones, Unprecedented Pyrazinones from Myxobacteria

Jansen R, Sood S, Mohr K, Kunze B, Irschik H, Stadler M, Müller R (2014)

J. Nat. Prod. 77 (11): 2545-2552DOI: 10.1021/np500632c

Disciformycins A and B: 12-membered macrolide glycoside antibiotics from the myxobacterium Pyxidicoccus fallax active against multiresistant staphylococci

Surup F, Viehrig K, Mohr K, Herrmann J, Jansen R, Müller R (2014)

Angew. Chem. Int. Ed. Engl. 49 (53): 13588-13591DOI: 10.1002/anie.201406973

Albaflavenol B, a new sesquiterpene isolated from the terrestrial actinomycete, Streptomyces sp.

Raju R, Gromyko O, Fedorenko V, Luzhetskyy A, Müller R (2014)

J. Antibiot. 68 (6): 286-288DOI: 10.1038/ja.2014.138

Improving natural products identification through targeted LC-MS/MS in an untargeted secondary metabolomics workflow

Hoffmann T, Krug D, Hüttel S, Müller R (2014)

Anal. Chem. 86 (21): 10780-10788DOI: 10.1021/ac502805w

Minicystis rosea gen. nov., sp. nov., a polyunsaturated fatty acid-rich and steroid-producing soil myxobacterium

Garcia R, Gemperlein K, Müller R (2014)

Int. J. Syst. Evol. Microbiol. 64 (Pt 11): 3733-3742DOI: 10.1099/ijs.0.068270-0

Cystobactamid und Derivate als Antibiotika

Baumann S, Herrmann J, Mohr K, Steinmetz H, Gerth K, Raju R, Müller R (2014)

Patent (1451)

Antimalarial activity of the myxobacterial macrolide chlorotonil A

Held J, Gebru T, Kalesse M, Jansen R, Gerth K, Müller R, Mordmüller B (2014)

Antimicrob. Agents Chemother. 58 (11): 6378-6384DOI: 10.1128/AAC.03326-14

Paenilarvins: Iturin family lipopeptides from the honey bee pathogen Paenibacillus larvae

Sood S, Steinmetz H, Beims H, Mohr K, Stadler M, Djukic M, Ohe W, Steinert M, Daniel R, Müller R (2014)

ChemBioChem 15 (13): 1947-1955DOI: 10.1002/cbic.201402139

Heterologous production of glidobactins/luminmycins in Escherichia coli nissle containing the glidobactin biosynthetic gene cluster from Burkholderia DSM7029

Bian X, Huang F, Wang H, Klefisch T, Müller R, Zhang Y (2014)

ChemBioChem 15 (15): 2221-2224DOI: 10.1002/cbic.201402199

Targeting the actin cytoskeleton: selective anti-tumor action via trapping PKCå

Vollmar A, Förster F, Braig S, Moser C, Kubisch R, Busse J, Wagner E, Schmöckel E, Mayr D, Schmitt S, …, Zischka H, Müller R (2014)

Cell Death & Disease 5DOI: 10.1038/cddis.2014.363

A highly unusual polyketide synthase directs dawenol polyene biosynthesis in Stigmatella aurantiaca

Oßwald C, Zaburannyi N, Burgard C, Hoffmann T, Wenzel S, Müller R (2014)

J. Biotechnol. 191: 54-63DOI: 10.1016/j.jbiotec.2014.07.447

Hyalachelins A-C, unusual siderophores isolated from the terrestrial myxobacterium Hyalangium minutum

Nadmid S, Plaza A, Lauro G, Garcia R, Bifulco G, Müller R (2014)

Org. Lett. 16 (16): 4130-4133DOI: 10.1021/ol501826a

Hyafurones, hyapyrrolines, and hyapyrones: polyketides from Hyalangium minutum

Okanya P, Mohr K, Gerth K, Kessler W, Jansen R, Stadler M, Müller R (2014)

J. Nat. Prod. 77 (6): 1420-1429DOI: 10.1021/np500145f

Biosynthesis of crocacin involves an unusual hydrolytic release domain showing similarity to condensation domains

Müller S, Rachid S, Hoffmann T, Surup F, Volz C, Zaburannyi N, Müller R (2014)

Chem. Biol. 21 (7): 855-865DOI: 10.1016/j.chembiol.2014.05.012

Angiolactone, a new Butyrolactone isolated from the terrestrial myxobacterium, Angiococcus sp.

Raju R, Garcia R, Müller R (2014)

J. Antibiot. epub ahead of printDOI: 10.1038/ja.2014.55

Cystomanamides: structure and biosynthetic pathway of a family of glycosylated lipopeptides from myxobacteria

Etzbach L, Plaza A, Garcia R, Baumann S, Müller R (2014)

Org. Lett. 16 (9): 2414-2417DOI: 10.1021/ol500779s

Indothiazinone, an indolyl-thiazolyl-ketone from a novel myxobacterium belonging to the Sorangiineae

Jansen R, Mohr K, Bernecker S, Stadler M, Müller R (2014)

J. Nat. Prod. 77 (4): 1054-1060DOI: 10.1021/np500144t

Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products

Krug D, Müller R (2014)

Nat. Prod. Rep. 31 (6): 768-783DOI: 10.1039/c3np70127a

Pyrronazols, metabolites from the myxobacteria Nannocystis pusilla and N. exedens, are unusual chlorinated pyrone-oxazole-pyrroles

Jansen R, Sood S, Huch V, Kunze B, Stadler M, Müller R (2014)

J. Nat. Prod. 77 (2): 320-326DOI: 10.1021/np400877r

Biosynthesis of magnetic nanostructures in a foreign organism by transfer of bacterial magnetosome gene clusters

Kolinko I, Lohße A, Borg S, Raschdorf R, Jogler C, Tu Q, Pósfai M, Tompa E, Plitzko J, Brachmann A, …, Zhang Y, Schüler D (2014)

Nat. Nanotechnol. 9 (3): 193-197DOI: 10.1038/nnano.2014.13

Oleamycins A and B: new antibacterial cyclic hexadepsipeptides isolated from a terrestrial Streptomyces sp.

Raju R, Gromyko O, Andriy B, Fedorenko V, Luzhetskyy A, Müller R (2014)

Journal of Antibiotics (Tokyo) 67 (4): 339-343DOI: 10.1038/ja.2014.1

Polyunsaturated fatty acid biosynthesis in myxobacteria

Gemperlein K, Rachid S, Garcia R, Wenzel S, Müller R (2014)

Chem. Sci. 5 (5): 1733-1741DOI: 10.1039/C3SC53163E

Improved seamless mutagenesis by recombineering using ccdB for counterselection

Wang H, Bian X, Xia L, Ding X, Müller R, Zhang Y, Fu J, Stewart A (2014)

Nucleic Acids Res. 42 (5)DOI: 10.1093/nar/gkt1339

Modular Construction of a Functional Artificial Epothilone Polyketide Pathway

Oßwald C, Zipf G, Schmidt G, Maier J, Bernauer H, Müller R, Wenzel S (2014)

ACS Synth. Biol. 3 (10): 759-772DOI: 10.1021/sb300080t

Future potential for anti-infectives from bacteria - How to exploit biodiversity and genomic potential

Müller R, Wink J (2014)

Int. J. Med. Microbiol. 304 (1): 3-13DOI: 10.1016/j.ijmm.2013.09.004

2013

Novel macrolide antibiotics

Müller R, Nett M, Surup F, Steinmetz H, Mohr K, Viehrig K (2013)

Patent (EP14002319)

Jahnellamides, a-keto-ß-methionine-containing peptides from the terrestrial myxobacterium Jahnella sp.: structure and biosynthesis

Plaza A, Viehrig K, Garcia R, Müller R (2013)

Org. Lett. 15 (22): 5882-5885DOI: 10.1021/ol402967y

Microsclerodermins from terrestrial myxobacteria: An intriguing biosynthesis likely connected to a sponge symbiont

Hoffmann T, Müller S, Nadmid S, Garcia R, Müller R (2013)

J. Am. Chem. Soc. 45 (135): 16904-16911DOI: 10.1021/ja4054509

Analytics of the therapeutic peptide aviptadil by sheathless CE-MS and comparison with nanoRP-HPLC-MS

Groß P, Burkart S, Müller R (2013)

J. Pharm. Biomed. Anal. 88 (2014): 477-482DOI: 10.1016/j.jpba.2013.09.024

Concerted action of P450 plus helper protein to form the amino-hydroxy-piperidone moiety of the potent protease inhibitor crocapeptin

Viehrig K, Surup F, Harmrolfs K, Jansen R, Kunze B, Müller R (2013)

J. Am. Chem. Soc. 135 (45): 16885-16894DOI: 10.1021/ja4047153

Production of fatty acids by heterologous expression of gene clusters from myxobacteria

Wenzel S, Rachid S, Gemperlein K, Müller R (2013)

Patent AC12P764FI (WO 2011/151298 A1)

Discovery and biological activity of new chondramides from Chondromyces sp.

Herrmann J, Hüttel S, Müller R (2013)

ChemBioChem 14 (13): 1573-1580DOI: 10.1002/cbic.201300140

Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues

Li X, Herrmann J, Zang Y, Grellier P, Prado S, Müller R, Nay B (2013)

Beilstein J. Org. Chem. 9: 1551-1558DOI: 10.3762/bjoc.9.176

Oleaceran: A novel spiro[isobenzofuran-1,2'-naptho[1,8-bc]furan] isolated from a terrestrial Streptomyces sp

Raju R, Gromyko O, Fedorenko V, Luzhetskyy A, Müller R (2013)

Org. Lett. 15 (14): 3487-3489DOI: 10.1021/ol401490u

Recent advances in the heterologous expression of microbial natural product biosynthetic pathways

Ongley S, Bian X, Neilan B, Müller R (2013)

Nat. Prod. Rep. 30 (8): 1121-1138DOI: 10.1039/c3np70034h

In vivo evidence for a prodrug activation mechanism during colibactin maturation

Bian X, Fu J, Plaza A, Herrmann J, Pistorius D, Stewart A, Zhang Y, Müller R (2013)

ChemBioChem 14 (10): 1194-1197DOI: 10.1002/cbic.201300208

Lorneic acids C and D, new trialkyl-substituted aromatic acids isolated from a terrestrial Streptomyces sp.

Raju R, Gromyko O, Fedorenko V, Luzhetskyy A, Müller R (2013)

J. Antibiot. 66 (6): 347-349DOI: 10.1038/ja.2013.18

Isolation, structure elucidation, and biological activity of maltepolides: remarkable macrolides from myxobacteria

Irschik H, Washausen P, Sasse F, Fohrer J, Huch V, Müller R, Prusov E (2013)

Angew. Chem. Int. Ed. Engl. 52 (20): 5402-5405DOI: 10.1002/anie.201210113

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

Arnison P, Bibb M, Bierbaum G, Bowers A, Bugni T, Bulaj G, Camarero J, Campopiano D, Challis G, Clardy J, …, Willey J, van der Donk W (2013)

Nat. Prod. Rep. 30 (1): 108-160DOI: 10.1039/C2NP20085F

Activity-guided screening of bioactive natural compounds implementing a new glucocorticoid-receptor-translocation assay and detection of new anti-inflammatory steroids from bacteria

Kaufmann K, Simmons L, Herrmann J, Schwär G, Luniak N, Müller R (2013)

Biotechnol. Lett. 35 (1): 11-20DOI: 10.1007/s10529-012-1042-0

2012

The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles

Ruge C, Schaefer U, Herrmann J, Kirch J, Cañadas O, Echaide M, Pérez-Gil J, Casals C, Müller R, Lehr C (2012)

PLoS ONE 7 (7)DOI: 10.1371/journal.pone.0040775

Method for producing recombinant 11-de-O-methyltomaymycin

Lattemann C, Broenstrup M, Werner S, Müller R, Harmrolfs K (2012)

Patent 2012 (EP2849753)

Pellasoren: structure elucidation, biosynthesis, and total synthesis of a cytotoxic secondary metabolite from Sorangium cellulosum

Jahns C, Hoffmann T, Müller S, Gerth K, Washausen P, Höfle G, Reichenbach H, Kalesse M, Müller R (2012)

Angew. Chem. Int. Ed. Engl. 51 (21): 5239-5243DOI: 10.1002/anie.201200327

Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting

Fu J, Bian X, Hu S, Wang H, Huang F, Seibert P, Plaza A, Xia L, Müller R, Stewart A, Zhang Y (2012)

Nat. Biotechnol. 30 (5): 440-446DOI: 10.1038/nbt.2183

Industrielle Mikrobiologie

Decker H, Dilsen S, Dürre P, Eikmanns B, Eikmanns M, Eggeling L, Elleuche S, Gallert C, Hagen S, Hausmann R, …, Wenzel S, Winter J (2012)

CollectedWorks 1stDOI: 10.1007/978-3-8274-3040-3

Ein alternativer isovaleryl-CoA-biosyntheseweg: beteiligung einer bisher unbekannten 3-methylglutaconyl-CoA-decarboxylase

Li Y, Luxenburger E, Müller R (2012)

Angew. Chem.DOI: 10.1002/ange.201207984

Rubimycinone A, a new anthraquinone from a terrestrial Streptomyces sp.

Raju R, Gromyko O, Fedorenko V, Herrmann J, Luzhetskyy A, Müller R (2012)

Tetrahedron Lett. 54 (8): 900-902DOI: 10.1016/j.tetlet.2012.11.130

Juniperolide A: a new polyketide isolated from a terrestrial actinomycete, Streptomyces sp.

Raju R, Gromyko O, Fedorenko V, Luzhetskyy A, Plaza A, Müller R (2012)

Org. Lett. 14 (23): 5860-5863DOI: 10.1021/ol302766z

An alternative isovaleryl CoA biosynthetic pathway involving a previously unknown 3-methylglutaconyl CoA decarboxylase

Li Y, Luxenburger E, Müller R (2012)

Angew. Chem. Int. Ed. Engl. 52 (4): 1304-1308DOI: 10.1002/anie.201207984

Enhancer binding proteins act as hetero-oligomers and link secondary metabolite production to myxococcal development, motility and predation

Volz C, Kegler C, Müller R (2012)

Chem. Biol. 19: 1447-1459DOI: 10.1016/j.chembiol.2012.09.010

Synthetic biotechnology to study and engineer ribosomal bottromycin biosynthesis

Huo L, Rachid S, Stadler M, Wenzel S, Müller R (2012)

Chem. Biol. 19 (10): 1278-1287DOI: 10.1016/j.chembiol.2012.08.013

Indiacens A and B: prenyl indoles from the myxobacterium Sandaracinus amylolyticus

Steinmetz H, Mohr K, Zander W, Jansen R, Gerth K, Müller R (2012)

J. Nat. Prod. 75 (10): 1803-1805DOI: 10.1021/np300288b

Leopolic acid A, isolated from a terrestrial actinomycete, Streptomyces sp.

Raju R, Gromyko O, Fedorenko V, Luzhetskyy A, Müller R (2012)

Tetrahedron Lett. 53 (46): 6300-6301DOI: 10.1016/j.tetlet.2012.09.046

Aetheramides A and B, potent HIV-inhibitory depsipeptides from a myxobacterium of the new genus 'Aetherobacter'

Plaza A, Garcia R, Bifulco G, Martinez J, Hüttel S, Sasse F, Meyerhans A, Stadler M, Müller R (2012)

Org. Lett. 14 (11): 2854-2857DOI: 10.1021/ol3011002

Luminmycins A-C, cryptic natural products from Photorhabdus luminescens identified by heterologous expression in Escherichia coli

Bian X, Plaza A, Zhang Y, Müller R (2012)

J. Nat. Prod. 75 (9): 1652-1655DOI: 10.1021/np300444e

Pretubulysin: From hypothetical biosynthetic intermediate to potential lead in tumor therapy

Herrmann J, Elnakady Y, Wiedmann R, Ullrich A, Rohde M, Kazmaier U, Vollmar A, Müller R (2012)

PLoS ONE 7 (5)DOI: 10.1371/journal.pone.0037416

Precursor-directed syntheses and biological evaluation of new elansolid derivatives

Steinmetz H, Zander W, Shushni M, Jansen G, Dehn R, Dräger G, Kirschning A, Müller R (2012)

ChemBioChem 13 (12): 1813-1817DOI: 10.1002/cbic.201200228

Methods to optimize myxobacterial fermentations using off-gas analysis

Hüttel S, Müller R (2012)

Microb. Cell Fact. 11 (59)DOI: 10.1186/1475-2859-11-59

A semipinacol rearrangement directed by an enzymatic system featuring dual-function FAD-dependent monooxygenase

Katsuyama Y, Harmrolfs K, Pistorius D, Li Y, Müller R (2012)

Angew. Chem. Int. Ed. Engl. 51 (37): 9437-9440DOI: 10.1002/anie.201204138

Direct cloning, genetic engineering, and heterologous expression of the syringolin biosynthetic gene cluster in E. coli through Red/ET recombineering

Bian X, Huang F, Stewart F, Xia L, Zhang Y, Müller R (2012)

ChemBioChem 13 (13): 1946-1952DOI: 10.1002/cbic.201200310

Eine Semipinakol-Umlagerung - katalysiert durch ein Enzymsystem mit difunktioneller FAD-abhängiger Monooxygenase

Katsuyama Y, Harmrolfs K, Pistorius D, Li Y, Müller R (2012)

Angew. Chem. Int. Ed. Engl. 124 (37): 9573-9576DOI: 10.1002/ange.201204138

Myxobacterium-produced antibiotic TA (myxovirescin) inhibits type II signal peptidase

Xiao Y, Gerth K, Müller R, Wall D (2012)

Antimicrob. Agents Chemother. 56 (4): 2014-2021DOI: 10.1128/AAC.06148-11

Pimprinols A-C, from the terrestrial actinomycete, Streptomyces sp.

Raju R, Gromyko O, Fedorenko V, Luzhetskyy A, Müller R (2012)

Tetrahedron Lett. 53 (24): 3009-3011DOI: 10.1016/j.tetlet.2012.03.134

Hyaladione, an S-methyl cyclohexadiene-dione from Hyalangium minutum

Okanya P, Mohr K, Gerth K, Steinmetz H, Huch V, Jansen R, Müller R (2012)

J. Nat. Prod. 75 (4): 768-770DOI: 10.1021/np200776v

Heterologous expression and genetic engineering of the tubulysin biosynthetic gene cluster using Red/ET recombineering and inactivation mutagenesis

Chai Y, Shan S, Weissman K, Hu S, Zhang Y, Müller R (2012)

Chem. Biol. 19 (3): 361-371DOI: 10.1016/j.chembiol.2012.01.007

Myxoprincomide: a natural product from Myxococcus xanthus discovered by comprehensive analysis of the secondary metabolome

Cortina N, Krug D, Plaza A, Revermann O, Müller R (2012)

Angew. Chem. Int. Ed. Engl. 51 (3): 811-816DOI: 10.1002/anie.201106305

Isolation and total synthesis of icumazoles and noricumazoles—antifungal antibiotics and cation-channel blockers from Sorangium cellulosum

Barbier J, Jansen R, Irschik H, Benson S, Gerth K, Böhlendorf B, Höfle G, Reichenbach H, Wegner J, Zeilinger C, Kirschning A, Müller R (2012)

Angew. Chem. Int. Ed. Engl. 51 (5): 1256-1260DOI: 10.1002/anie.201106435

Unusual carbon fixation gives rise to diverse polyketide extender units

Quade N, Huo L, Rachid S, Heinz D, Müller R (2012)

Nat. Chem. Biol. 8 (1): 117-124DOI: 10.1038/nchembio.734

Sandaracinus amylolyticus gen. nov., sp. nov., a starch-degrading soil myxobacterium, and description of Sandaracinaceae fam. nov

Mohr K, Garcia R, Gerth K, Irschik H, Müller R (2012)

Int. J. Syst. Evol. Microbiol. 62 (Pt 5): 1191-1198DOI: 10.1099/ijs.0.033696-0

Discovery of the rhizopodin biosynthetic gene cluster in Stigmatella aurantiaca Sg a15 by genome mining

Pistorius D, Müller R (2012)

Chembiochem : a European journal of chemical biology 13 (3): 416-426DOI: 10.1002/cbic.201100575

2011

Completing the puzzle of aurachin biosynthesis in Stigmatella aurantiaca Sg a15

Pistorius D, Li Y, Sandmann A, Müller R (2011)

Mol. Biosyst. 7 (12): 3308-3315DOI: 10.1039/c1mb05328k

AuaA, a membrane-bound farnesyltransferase from Stigmatella aurantiaca, catalyzes the prenylation of 2-methyl-4-hydroxyquinoline in the biosynthesis of aurachins

Stec E, Pistorius D, Müller R, Li S (2011)

ChemBioChem 12 (11): 1724-1730DOI: 10.1002/cbic.201100188

Unprecedented anthranilate priming involving two enzymes of the acyl adenylating superfamily in aurachin biosynthesis

Pistorius D, Li Y, Mann S, Müller R (2011)

J. Am. Chem. Soc. 133 (32): 12362-12365DOI: 10.1021/ja203653w

A highly conjugated dihydroxylated C28 steroid from a myxobacterium

Gawas D, Garcia R, Huch V, Müller R (2011)

Journal of natural products 74 (5): 1281-1283DOI: 10.1021/np100682c

Bendigoles D-F, bioactive sterols from the marine sponge-derived Actinomadura sp. SBMs009

Simmons L, Kaufmann K, Garcia R, Schwär G, Huch V, Müller R (2011)

Bioorganic & Medicinal Chemistry 19 (22): 6570-6575DOI: 10.1016/j.bmc.2011.05.044

Elansolid A3, a unique p-quinone methide antibiotic from Chitinophaga sancti

Jansen R, Gerth K, Steinmetz H, Reinecke S, Kessler W, Kirschning A, Müller R (2011)

Chem. Eur. J. 17 (28): 7739-7744DOI: 10.1002/chem.201100457

Molecular basis of elansolid biosynthesis: evidence for an unprecedented quinone methide initiated intramolecular Diels-Alder cycloaddition/macrolactonization

Dehn R, Katsuyama Y, Weber A, Gerth K, Jansen R, Steinmetz H, Höfle G, Müller R, Kirschning A (2011)

Angew. Chem. Int. Ed. Engl. 50 (17): 3882-3887DOI: 10.1002/anie.201006880

Roimatacene: an antibiotic against gram-negative bacteria isolated from Cystobacter ferrugineus Cb G35 (myxobacteria)

Zander W, Gerth K, Mohr K, Kessler W, Jansen R, Müller R (2011)

Chem. Eur. J. 17 (28): 7875-7881DOI: 10.1002/chem.201003677

p-Hydroxyacetophenone amides from Cystobacter ferrugineus, strain Cb G35

Zander W, Mohr K, Gerth K, Jansen R, Müller R (2011)

J. Nat. Prod. 74 (6): 1358-1363DOI: 10.1021/np1006789

Identification and characterization of the althiomycin biosynthetic gene cluster in Myxococcus xanthus DK897

Cortina N, Revermann O, Krug D, Müller R (2011)

ChemBioChem 12 (9): 1411-1416DOI: 10.1002/cbic.201100154

Fatty acid-related phylogeny of myxobacteria as an approach to discover polyunsaturated omega-3/6 fatty acids

Garcia R, Pistorius D, Stadler M, Müller R (2011)

J. Bacteriol. 193 (8): 1930-1942DOI: 10.1128/JB.01091-10

Biosynthesis of 2-alkyl-4(1H)-quinolones in Pseudomonas aeruginosa: potential for therapeutic interference with pathogenicity

Pistorius D, Ullrich A, Lucas S, Hartmann R, Kazmaier U, Müller R (2011)

ChemBioChem 12 (6): 850-853DOI: 10.1002/cbic.201100014

Marinoquinolines A-F, Pyrroloquinolines from Ohtaekwangia kribbensis (Bacteroidetes)

Okanya P, Mohr K, Gerth K, Jansen R, Müller R (2011)

J. Nat. Prod. 74 (4): 603-608DOI: 10.1021/np100625a

Insights into the complex biosynthesis of the leupyrrins in Sorangium cellulosum So ce690

Kopp M, Irschik H, Gemperlein K, Buntin K, Meiser P, Weissman K, Bode H, Müller R (2011)

Mol. Biosyst. 7 (5): 1549-1563DOI: 10.1039/c0mb00240b

Mining the cinnabaramide biosynthetic pathway to generate novel proteasome inhibitors

Rachid S, Huo L, Herrmann J, Stadler M, Köpcke B, Bitzer J, Müller R (2011)

ChemBioChem 12 (6): 922-931DOI: 10.1002/cbic.201100024

Elansolid A, a unique macrolide antibiotic from Chitinophaga sancti isolated as two stable atropisomers

Steinmetz H, Gerth K, Jansen R, Schläger N, Dehn R, Reinecke S, Kirschning A, Müller R (2011)

Angew. Chem. Int. Ed. Engl. 50 (2): 532-536DOI: 10.1002/anie.201005226

2010

Heterologous hosts

Zhang Y, Fu J, Bian X, Stewart A, Müller R (2010)

Patent (US 9,580,717 B2)

The CYPome of Sorangium cellulosum So ce56 and identification of CYP109D1 as a new fatty acid hydroxylase

Khatri Y, Hannemann F, Ewen K, Pistorius D, Perlova O, Kagawa N, Brachmann A, Müller R, Bernhardt R (2010)

Chem. Biol. 17: 1295-1305DOI: 10.1016/j.chembiol.2010.10.010

Production of omega-3 fatty acids by myxobacteria International Patent

Stadler M, Roemer E, Müller R, Garcia R, Pistorius D, Brachmann A (2010)

Patent (International Patent WO 2010/063451 A2)

Volatile Methyl Esters of Medium Chain Length from the Bacterium Chitinophaga Fx7914

Nawrath T, Gerth K, Müller R, Schulz S (2010)

Chemistry & Biodiversity 7 (9): 2228-2253

The Biosynthesis of the Aroma Volatile 2-Methyltetrahydrothiophen-3-one in the Bacterium Chitinophaga Fx7914

Nawrath T, Gerth K, Müller R, Schulz S (2010)

ChemBioChem 11 (13): 1914-1919DOI: 10.1002/cbic.201000296

Expanded phylogeny of myxobacteria and evidence for cultivation of the 'unculturables'

Garcia R, Gerth K, Stadler M, Dogma Jr. I, Müller R (2010)

Mol. Phylogenet. Evol. 57 (2): 878-887DOI: 10.1016/j.ympev.2010.08.028

Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster

Binz T, Maffioli S, Sosio M, Donadio S, Müller R (2010)

J. Biol. Chem. 285 (43): 32710-32719DOI: 10.1074/jbc.M110.146803

Analysis of the sorangicin gene cluster reinforces the utility of a combined phylogenetic/retrobiosynthetic analysis for deciphering natural product assembly by trans-AT PKS

Irschik H, Kopp M, Weissman K, Buntin K, Piel J, Müller R (2010)

ChemBioChem 11 (13): 1840-1849DOI: 10.1002/cbic.201000313

Functions of genes and enzymes involved in phenalinolactone biosynthesis

Daum M, Schnell H, Herrmann S, Günther A, Murillo R, Müller R, Bisel P, Müller M, Bechtlold A (2010)

ChemBioChem 11 (10): 1383-1391DOI: 10.1002/cbic.201000117

Myxobacterial secondary metabolites: bioactivities and modes-of-action

Weissman K, Müller R (2010)

Nat. Prod. Rep. 27 (9): 1276-1295DOI: 10.1039/c001260m

Biosynthesis of thuggacins in myxobacteria: comparative cluster analysis reveals basis for natural product structural diversity

Buntin K, Irschik H, Weissman K, Luxenburger E, Blöcker H, Müller R (2010)

Chem. Biol. 17 (4): 342-356DOI: 10.1016/j.chembiol.2010.02.013

Biosynthesis of the myxobacterial antibiotic corallopyronin A

Erol Ö, Schäberle T, Schmitz A, Rachid S, Gurgui C, El Omari M, Lohr F, Kehraus S, Piel J, Müller R, König G (2010)

ChemBioChem 11 (9): 1235-1265DOI: 10.1002/cbic.201000085

Carolacton - a Macrolide Ketocarbonic Acid Reducing Biofilm Formation by the Caries- and Endocarditis-associated Bacterium Streptococcus mutans

Jansen R, Irschik H, Huch V, Schummer D, Steinmetz H, Bock M, Schmidt T, Kirschning A, Müller R (2010)

Eur. J. Org. Chem. 2010 (7): 1284-1289DOI: 10.1002/ejoc.200901126

An unusual thioesterase promotes isochromanone ring formation in ajudazol biosynthesis

Buntin K, Weissman K, Müller R (2010)

ChemBioChem 11 (8): 1137-1146DOI: 10.1002/cbic.200900712

Insights into multienzyme docking in hybrid PKS-NRPS megasynthetases revealed by heterologous expression and genetic engineering

Li Y, Weissman K, Müller R (2010)

ChemBioChem 11 (8): 1069-1075DOI: 10.1002/cbic.201000103

Discovery of 23 natural tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004

Chai Y, Pistorius D, Ullrich A, Weissman K, Kazmaier U, Müller R (2010)

Chem. Biol. 17 (3): 296-309DOI: 10.1016/j.chembiol.2010.01.016

Characterization of a novel type of oxidative decarboxylase involved in the biosynthesis of the styryl moiety of chondrochloren from an acylated tyrosine

Rachid S, Revermann O, Dauth C, Müller R (2010)

J. Biol. Chem. 285 (17): 12482-12489DOI: 10.1074/jbc.M109.079707

2009

Pretubulysin, a potent and chemically accessible tubulysin precursor from Angiococcus disciformis

Ullrich A, Chai Y, Pistorius D, Elnakady Y, Herrmann J, Weissman K, Kazmaier U, Müller R (2009)

Angew. Chem. Int. Ed. Engl. 48 (24): 4422-4425DOI: 10.1002/anie.200900406

Progress in the chemistry of organic natural products

Altmann K, Höfle G, Müller R, Mulzer J, Prantz K (2009)

CollectedWorks

Synthesis and Biological Evaluation of Pretubulysin and Derivatives

Ullrich A, Herrmann J, Müller R, Kazmaier U (2009)

Eur. J. Org. Chem. 2009 (36): 6367-6378

Genome mining in Sorangium cellulosum So ce56 - identification and characterization of the homologous electron transfer proteins of a myxobacterial cytochrome P450

Ewen K, Hannemann F, Khatri Y, Perlova O, Kappl R, Krug D, Hüttermann J, Müller R, Bernhardt R (2009)

J. Biol. Chem. 284 (42): 28590-28598DOI: 10.1074/jbc.M109.021717

The impact of genomics on the exploitation of the myxobacterial secondary metabolome

Wenzel S, Müller R (2009)

Nat. Prod. Rep. 26 (11): 1385-1407DOI: 10.1039/b817073h

Non-modular polyketide synthases in myxobacteria

Li Y, Müller R (2009)

Phytochemistry 70 (15-16): 1850-1857

Myxobacteria--'microbial factories' for the production of bioactive secondary metabolites

Wenzel S, Müller R (2009)

Mol. Biosyst. 5 (6): 567-574DOI: 10.1039/b901287g

The biosynthetic potential of myxobacteria and their impact on drug discovery

Wenzel S, Müller R (2009)

Curr. Opin. Drug Discov. Devel. 12 (2): 220-230

Structure and action of the myxobacterial chondrochloren halogenase CndH: a new variant of FAD-dependent halogenases

Buedenbender S, Rachid S, Müller R, Schulz G (2009)

J. Mol. Biol. 385 (2): 520-530DOI: 10.1016/j.jmb.2008.10.057

Novel expression hosts for complex secondary metabolite megasynthetases: Production of myxochromide in the thermopilic isolate Corallococcus macrosporus GT-2

Perlova O, Gerth K, Kuhlmann S, Zhang Y, Müller R (2009)

Microb. Cell Fact. 8 (1)DOI: 10.1186/1475-2859-8-1

Identification of additional players in the alternative biosynthesis pathway to isovaleryl-CoA in the myxobacterium Myxococcus xanthus

Bode H, Ring M, Schwär G, Altmeyer M, Kegler C, Jose I, Singer M, Müller R (2009)

ChemBioChem 10 (1): 128-140DOI: 10.1002/cbic.200800219

Unusual chemistry in the biosynthesis of the antibiotic chondrochlorens

Rachid S, Scharfe M, Blöcker H, Weissman K, Müller R (2009)

Chem. Biol. 16 (1): 70-81DOI: 10.1016/j.chembiol.2008.11.005

Discovery of additional members of the tyrosine aminomutase enzyme family and the mutational analysis of CmdF

Krug D, Müller R (2009)

ChemBioChem 10 (4): 741-750DOI: 10.1002/cbic.200800748

Phaselicystis flava gen. nov., sp. nov., an arachidonic acid-containing soil myxobacterium, and the description of Phaselicystidaceae fam. nov

Garcia R, Reichenbach H, Ring M, Müller R (2009)

Int. J. Syst. Evol. Microbiol. 59 (6): 1524-1530DOI: 10.1099/ijs.0.003814-0

A brief tour of myxobacterial secondary metabolism

Weissman K, Müller R (2009)

Bioorganic & Medicinal Chemistry 17 (6): 2121-2136DOI: 10.1016/j.bmc.2008.11.025

2008

Epothilones - a fascinating family of microtubule stabilizing antitumor agents

Mulzer J, Altmann K, Hofle G, Müller R, Prantz K (2008)

Comptes Rendus Chimie 11 (11-12): 1336-1368DOI: 10.1016/j.crci.2008.02.005

Isolation and structure revision of the actin-binding macrolide rhizopodin from Myxococcus stipitatus (Myxobacteria)

Jansen R, Steinmetz H, Sasse F, Schubert W, Hagelueken G, Albrecht S, Müller R (2008)

Tetrahedron Lett. 49 (40): 5796-5799DOI: 10.1016/j.tetlet.2008.07.132

NtcA-A negative regulator of secondary metabolite biosynthesis in Sorangium cellulosum

Rachid S, Gerth K, Müller R (2008)

J. Biotechnol. 140 (1-2): 135-142DOI: 10.1016/j.jbiotec.2008.10.010

Epothilones - A fascinating family of microtubule stabilizing antitumor agents

Mulzer J, Altmann K, Höfle G, Müller R, Prantz K (2008)

C. R. Chimie 11

A type I/type III polyketide synthase hybrid biosynthetic pathway for the structurally unique ansa compound kendomycin

Wenzel S, Bode H, Kochems I, Müller R (2008)

ChemBioChem 9 (16): 2711-2721DOI: 10.1002/cbic.200800456

Crystal structure of a molecular assembly line

Weissman K, Müller R (2008)

Angew. Chem. Int. Ed. Engl. 47 (44): 8344-8346DOI: 10.1002/anie.200803293

Stereochemical determination and complex biosynthetic assembly of etnangien, a highly potent RNA polymerase inhibitor from the myxobacterium Sorangium cellulosum

Menche D, Arikan F, Perlova O, Horstmann N, Ahlbrecht W, Wenzel S, Jansen R, Irschik H, Müller R (2008)

J. Am. Chem. Soc. 130 (43): 14234-14243DOI: 10.1021/ja804194c

DKxanthene biosynthesis - understanding the basis for diversity-oriented synthesis in myxobacterial secondary metabolism

Meiser P, Weissman K, Bode H, Krug D, Dickschat J, Sandmann A, Müller R (2008)

Chem. Biol. 15 (8): 771-781DOI: 10.1016/j.chembiol.2008.06.005

Two functionally redundant Sfp-type 4'-phosphopantetheinyl transferases differentially activate biosynthetic pathways in Myxococcus xanthus

Meiser P, Müller R (2008)

ChemBioChem 9 (10): 1549-1553DOI: 10.1002/cbic.200800077

Stereochemical determination of thuggacins A-C, highly active antibiotics from the myxobacterium Sorangium cellulosum

Bock M, Buntin K, Müller R, Kirschning A (2008)

Angew. Chem. Int. Ed. Engl. 47 (12): 2308-2311DOI: 10.1002/anie.200704897

Efficient transfer of two large secondary metabolite pathway gene clusters into heterologous hosts by transposition

Fu J, Wenzel S, Perlova O, Wang J, Gross F, Tang Z, Yin Y, Stewart A, Müller R, Zhang Y (2008)

Nucleic Acids Res. 36 (17)DOI: 10.1093/nar/gkn499

A transposon-based strategy to scale up myxothiazol production in myxobacterial cell factories

Sandmann A, Frank B, Müller R (2008)

J. Biotechnol. 135 (3): 255-261DOI: 10.1016/j.jbiotec.2008.05.001

Efficient mining of myxobacterial metabolite profiles enabled by liquid chromatography-electrospray ionization-time-of-flight mass spectrometry and compound-based principal component analysis

Krug D, Zurek G, Schneider B, Garcia R, Müller R (2008)

Anal. Chim. Acta 624 (1): 97-106DOI: 10.1016/j.aca.2008.06.036

Myxochelin biosynthesis: direct evidence for two- and four-electron reduction of a carrier protein-bound thioester

Li Y, Weissman K, Müller R (2008)

J. Am. Chem. Soc. 130 (24): 7554-7555DOI: 10.1021/ja8025278

Heterologous expression and genetic engineering of the phenalinolactone biosynthetic gene cluster by using Red/ET recombineering

Binz T, Wenzel S, Schnell H, Bechthold A, Müller R (2008)

ChemBioChem 9 (3): 447-454DOI: 10.1002/cbic.200700549

Protein-protein interactions in multienzyme megasynthetases

Weissman K, Müller R (2008)

ChemBioChem 9 (6): 826-848DOI: 10.1002/cbic.200700751

Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase

Petkovic H, Sandmann A, Challis I, Hecht H, Silakowski B, Low L, Beeston N, Kuscer E, Garcia-Bernardo J, Leadlay P, …, Wilkinson B, Müller R (2008)

Org. Biomol. Chem. 6 (3): 500-506DOI: 10.1039/b714804f

Production of the antifungal isochromanone ajudazols A and B in Chondromyces crocatus Cm c5: biosynthetic machinery and cytochrome P450 modifications

Buntin K, Rachid S, Scharfe M, Blöcker H, Weissman K, Müller R (2008)

Angew. Chem. Int. Ed. Engl. 47 (24): 4595-4599DOI: 10.1002/anie.200705569

Discovering the Hidden Secondary Metabolome of Myxococcus xanthus: a Study of Intraspecific Diversity

Krug D, Zurek G, Revermann O, Vos M, Velicer G, Müller R (2008)

Appl. Environ. Microbiol. 74 (10): 3058-3068DOI: 10.1128/AEM.02863-07

2007

Complete genome sequence of the myxobacterium Sorangium cellulosum

Schneiker S, Perlova O, Kaiser O, Gerth K, Alici A, Altmeyer M, Bartels D, Bekel T, Beyer S, Bode E, …, Pühler A, Müller R (2007)

Nat. Biotechnol. 25 (11): 1281-1289DOI: 10.1038/nbt1354

From genetic diversity to metabolic unity: studies on the biosynthesis of aurafurones and aurafuron-like structures in myxobacteria and streptomycetes

Frank B, Wenzel S, Bode H, Scharfe M, Blöcker H, Müller R (2007)

J. Mol. Biol. 374 (1): 24-38DOI: 10.1016/j.jmb.2007.09.015

Mutasynthesis-derived myxalamids and origin of the isobutyryl-CoA starter unit of myxalamid B

Bode H, Meiser P, Klefisch T, Cortina N, Krug D, Göhring A, Schwär G, Mahmud T, Elnakady Y, Müller R (2007)

ChemBioChem 8 (17): 2139-2144DOI: 10.1002/cbic.200700401

Mutational analysis of the myxovirescin biosynthetic gene cluster reveals novel insights into the functional elaboration of polyketide backbones

Simunovic V, Müller R (2007)

ChemBioChem 8 (11): 1273-1280DOI: 10.1002/cbic.200700153

Biosynthesis of (R)-beta-tyrosine and its incorporation into the highly cytotoxic chondramides produced by Chondromyces crocatus

Rachid S, Krug D, Weissman K, Müller R (2007)

J. Biol. Chem. 282 (30): 21810-21817DOI: 10.1074/jbc.M703439200

Myxobacterial natural product assembly lines: fascinating examples of curious biochemistry

Wenzel S, Müller R (2007)

Nat. Prod. Rep. 24 (6): 1211-1224DOI: 10.1039/b706416k

Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycin

Elnakady Y, Rohde M, Sasse F, Backes C, Keller A, Lenhof H, Weissman K, Müller R (2007)

ChemBioChem 8 (11): 1261-1272DOI: 10.1002/cbic.200700050

SorF, a glycosyltransferase with promiscuous donor substrate specificity in vitro

Kopp M, Rupprath C, Irschik H, Bechthold A, Elling L, Müller R (2007)

ChemBioChem 8 (7): 813-819DOI: 10.1002/cbic.200700024

Spiroketal polyketide formation in Sorangium: Identification and analysis of the biosynthetic gene cluster for the highly cytotoxic spirangienes

Frank B, Knauber J, Steinmetz H, Scharfe M, Blöcker H, Beyer S, Müller R (2007)

Chem. Biol. 14 (2): 221-233DOI: 10.1016/j.chembiol.2006.11.013

3-Hydroxy-3-methylglutaryl-CoA-like synthases direct the formation of methyl and ethyl side groups in the biosynthesis of the antibiotic myxovirescin A

Simunovic V, Müller R (2007)

ChemBioChem 8 (5): 497-500DOI: 10.1002/cbic.200700017

Deciphering regulatory mechanisms for secondary metabolite production in the myxobacterium Sorangium cellulosum So ce56

Rachid S, Gerth K, Kochems I, Müller R (2007)

Mol. Microbiol. 63 (6): 1783-1796DOI: 10.1111/j.1365-2958.2007.05627.x

Reversible sugar transfer by glycosyltransferases as atool for natural product (bio)synthesis

Bode H, Müller R (2007)

Angew. Chem. Int. Ed. Engl. 46 (13): 2147-2150DOI: 10.1002/anie.200604671

A type II polyketide synthase from the gram-negative bacterium Stigmatella aurantiaca is involved in aurachin alkaloid biosynthesis

Sandmann A, Dickschat J, Jenke-Kodama H, Kunze B, Dittmann E, Müller R (2007)

Angew. Chem. Int. Ed. Engl. 46 (15): 2712-2716DOI: 10.1002/anie.200603513

2006

Analysis of myxobacterial secondary metabolism goes molecular

Bode H, Müller R (2006)

J. Ind. Microbiol. Biotechnol. 33 (7): 577-588DOI: 10.1007/s10295-006-0082-7

The unique DKxanthene secondary metabolite family from the myxobacterium Myxococcus xanthus is required for developmental sporulation

Meiser P, Bode H, Müller R (2006)

Proc. Natl. Acad. Sci. U.S.A. 103 (50): 19128-19133DOI: 10.1073/pnas.0606039103

Exploiting microbial diversity and bacterial genomics to find novel antibiotics

Müller R (2006)

Int. J. Med. Microbiol. 296S3 (42): 138-139

Metabolic engineering of Pseudomonas putida for methylmalonyl-CoA biosynthesis to enable complex heterologous secondary metabolite formation

Gross F, Ring M, Perlova O, Fu J, Schneider S, Gerth K, Kuhlmann S, Stewart A, Zhang Y, Müller R (2006)

Chem. Biol. 13 (12): 1253-1264DOI: 10.1016/j.chembiol.2006.09.014

Metabolic physiology of Pseudomonas putida for heterologous production of myxochromide

Stephan S, Heinzle E, Wenzel S, Krug D, Müller R, Wittmann C (2006)

Process Biochem. 41 (2006): 2146-2152DOI: 10.1016/j.procbio.2006.06.022

On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of 'glycolate' units into ansamitocin and soraphen A

Wenzel S, Williamson R, Grünanger C, Xu J, Gerth K, Martinez R, Moss S, Carroll B, Grond S, Unkefer C, Müller R, Floss H (2006)

J. Am. Chem. Soc. 128 (44): 14325-14336DOI: 10.1021/ja064408t

Proteome analysis of Myxococcus xanthus by off-line two-dimensional chromatographic separation using monolithic poly-(styrene-divinylbenzene) columns combined with ion-trap tandem mass spectrometry

Schley C, Altmeyer M, Swart R, Müller R, Huber C (2006)

J. Proteome Res. 5 (10): 2760-2768DOI: 10.1021/pr0602489

Biochemical characterization of MelJ and MelK - myxobacterial enzymes that transform an amide into a methyl ester

Müller I, Müller R (2006)

FEBS J. 273 (16): 3768-3778DOI: 10.1111/j.1742-4658.2006.05385.x

3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in the biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation

Bode H, Ring M, Schwär G, Kroppenstedt R, Kaiser D, Müller R (2006)

J. Bacteriol. 188 (18): 6524-6528DOI: 10.1128/JB.00825-06

A unique mechanism for methyl ester formation via an amide intermediate found in myxobacteria

Müller I, Weinig S, Steinmetz H, Kunze B, Veluthoor S, Mahmud T, Müller R (2006)

ChemBioChem 7 (8): 1197-1205DOI: 10.1002/cbic.200600057

Reconstitution of myxothiazol biosynthetic gene cluster by Red/ET recombination and heterologous expression in Myxococcus xanthus

Perlova O, Fu J, Kuhlmann S, Krug D, Stewart F, Zhang Y, Müller R (2006)

Appl. Environ. Microbiol. 72 (12): 7485-7494DOI: 10.1128/AEM.01503-06

Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis

Berner M, Krug D, Bihlmaier C, Vente A, Müller R, Bechthold A (2006)

J. Bacteriol. 188 (7): 2666-2673DOI: 10.1128/JB.188.7.2666–2673.2006

Myxovirescin biosynthesis is directed by hybrid polyketide synthases/ nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl CoA synthases and trans-acting acyltransferases

Simunovic V, Zapp J, Rachid S, Krug D, Meiser P, Müller R (2006)

ChemBioChem 7 (8): 1206-1220DOI: 10.1002/cbic.200600075

Development of simple media which allow investigations into the global regulation of chivosazol biosynthesis with Sorangium cellulosum So ce56

Müller R, Gerth K (2006)

J. Biotechnol. 121 (2): 192-200DOI: 10.1016/j.jbiotec.2005.10.012

Molecular and biochemical studies of chondramide formation - highly cytotoxic natural products from Chondromyces crocatus Cm c5

Rachid S, Krug D, Kochems I, Kunze B, Scharfe M, Blöcker H, Zabriski M, Müller R (2006)

Chem. Biol. 14: 667-681DOI: 10.1016/j.chembiol.2006.06.002

Establishment of a real-time PCR protocol for expression studies of secondary metabolite biosynthetic gene clusters in the G/C-rich myxobacterium Sorangium cellulosum So ce56

Kegler C, Gerth K, Müller R (2006)

J. Biotechnol. 121 (2): 201-212DOI: 10.1016/j.jbiotec.2005.10.007

Nonribosomal Peptide Biosynthesis: Point Mutations and Module Skipping Lead to Chemical Diversity

Wenzel S, Meiser P, Binz T, Mahmud T, Müller R (2006)

Angew. Chem. Int. Ed. Engl. 45 (14): 2296-2301DOI: 10.1002/anie.200503737

Identification of StiR, the first regulator of secondary metabolite formation in the myxobacterium Cystobacter fuscus Cb f17.1

Rachid S, Sasse F, Beyer S, Müller R (2006)

J. Biotechnol. 121 (4): 429-441DOI: 10.1016/j.jbiotec.2005.08.014

Bacterial type III polyketide synthases: Phylogenetic analysis and potential for the production of novel secondary metabolites by heterologous expression in pseudomonads

Gross F, Luniak N, Perlova O, Gaitatzis N, Jenke-Kodama H, Gerth K, Gottschalk D, Dittmann E, Müller R (2006)

Arch. Microbiol. 185 (1): 28-38DOI: 10.1007/s00203-005-0059-3

Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56

Perlova O, Gerth K, Hans A, Kaiser O, Müller R (2006)

J. Biotechnol. 121 (2): 174-191DOI: 10.1016/j.jbiotec.2005.10.011

2005

Moderately thermophilic myxobacteria: novel potential for the production of natural products isolation and characterization

Gerth K, Müller R (2005)

Environ. Microbiol. 7 (6): 874-880DOI: 10.1111/j.1462-2920.2005.00761.x

Heterologe Expression von komplexen myxobakteriellen Naturstoff-Biosynthesewegen in Pseudomonaden

Wenzel S, Müller R (2005)

Biospektrum 11 (5): 628-631

Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways

Wenzel S, Müller R (2005)

Curr. Opin. Biotechnol. 16 (6): 594-606DOI: 10.1016/j.copbio.2005.10.001

Evolutionary implications of bacterial polyketide synthases

Jenke-Kodama H, Sandmann A, Müller R, Dittmann E (2005)

Mol. Biol. Evol. 22 (10): 2027-2039DOI: 10.1093/molbev/msi193

The impact of bacterial genomics on natural product research

Bode H, Müller R (2005)

Angew. Chem. Int. Ed. Engl. 44 (42): 6828-6846DOI: 10.1002/anie.200501080

Production of the tubulin destabilizer disorazol in Sorangium cellulosum: biosynthetic machinery and regulatory genes

Kopp M, Irschik H, Pradella S, Müller R (2005)

ChemBioChem 6 (7): 1277-1286DOI: 10.1002/cbic.200400459

Formation of novel secondary metabolites by bacterial multimodular assembly lines: deviations from text book biosynthetic logic

Wenzel S, Müller R (2005)

Curr. Opin. Chem. Biol. 9: 447-458DOI: 10.1016/j.cbpa.2005.08.001

Aurafuron A and B, new bioactive polyketides from Stigmatella aurantiaca and Archangium gephyra (myxobacteria)

Kunze B, Reichenbach H, Müller R, Höfle G (2005)

J. Antibiot. 58 (4): 244-251

A novel type of geosmin biosynthesis in myxobacteria

Dickschat J, Bode H, Mahmud T, Müller R, Schulz S (2005)

J. Org. Chem. 70 (13): 5174-5182DOI: 10.1021/jo050449g

Novel insights into siderophore formation in myxobacteria

Gaitatzis N, Kunze B, Müller R (2005)

ChemBioChem 6 (2): 365-374DOI: 10.1002/cbic.200400206

Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering

Wenzel S, Gross F, Zhang Y, Fu J, Stewart F, Müller R (2005)

Chem. Biol. 12 (3): 349-356DOI: 10.1016/j.chembiol.2004.12.012

Structure and Biosynthesis of Myxochromides S1-3 in Stigmatella aurantiaca: Evidence for An Iterative Bacterial Type I Polyketide Synthase and for Module Skipping in Nonribosomal Peptide Biosynthesis

Wenzel S, Kunze B, Höfle G, Silakowski B, Scharfe M, Blöcker H, Müller R (2005)

ChemBioChem 6 (2): 375-385DOI: 10.1002/cbic.200400282

Posttranslational modification of myxobacterial carrier protein domains in Pseudomonas sp. by an intrinsic phosphopantetheinyl transferase

Gross F, Gottschalk D, Müller R (2005)

Appl. Microbiol. Biotechnol. 68 (1): 66-74DOI: 10.1007/s00253-004-1836-7

Biosynthesis of iso-fatty acids in myxobacteria: iso-even fatty acids are derived by alpha-oxidation of iso-odd fatty acids

Bode H, Dickschat J, Kroppenstedt R, Schulz S, Müller R (2005)

J. Am. Chem. Soc. 127 (2): 532-533DOI: 10.1021/ja043570y

A novel biosynthetic pathway to isovaleryl-CoA in myxobacteria: The involvement of the mevalonate pathway

Mahmud T, Wenzel S, Wan E, Wen K, Bode H, Gaitatzis N, Müller R (2005)

ChemBioChem 6 (2): 322-330DOI: 10.1002/cbic.200400261

2004

Methods for heterologous expression of secondary metabolites

Wenzel S, Gross F, Zhang Y, Stewart F, Müller R (2004)

Patent

Identification and analysis of the core biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity

Sandmann A, Sasse F, Müller R (2004)

Chem. Biol. 11 (8): 1071-1079DOI: 10.1016/j.chembiol.2004.05.014

Unusual biosynthesis of leupyrrins in the myxobacterium Sorangium cellulosum

Bode H, Wenzel S, Irschik H, Höfle G, Müller R (2004)

Angew. Chem. Int. Ed. Engl. 43 (32): 4163-4167DOI: 10.1002/anie.200454240

Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus

Dickschat J, Wenzel S, Bode H, Müller R, Schulz S (2004)

ChemBioChem 5 (6): 778-787DOI: 10.1002/cbic.200300813

Don't classify polyketide synthases

Müller R (2004)

Chem. Biol. 11 (1): 4-6DOI: 10.1016/j.chembiol.2004.01.005

Critical variations of conjugational DNA transfer into secondary metabolite multiproducing Sorangium cellulosum strains So ce12 and So ce56: development of a mariner-based transposon mutagenesis system

Kopp M, Irschik H, Gross F, Perlova O, Sandmann A, Gerth K, Müller R (2004)

J. Biotechnol. 107 (1): 29-40DOI: 10.1016/j.jbiotec.2003.09.013

2003

Melithiazol biosynthesis: further insights into myxobacterial PKS/NRPS systems and evidence for a new subclass of methyl transferases

Weinig S, Hecht H, Mahmud T, Müller R (2003)

Chem. Biol. 10 (10): 939-952DOI: 10.1016/j.chembiol.2003.09.012

Markerless mutations in the myxothiazol biosynthetic gene cluster: A delicate megasynthetase with a superfluous nonribosomal peptide synthetase domain

Weinig S, Mahmud T, Müller R (2003)

Chem. Biol. 10 (10): 953-960DOI: 10.1016/j.chembiol.2003.09.013

Myxobacteria: proficient producers of novel natural products with various biological activities - past and future biotechnological aspects with the focus on the genus Sorangium

Gerth K, Pradella S, Perlova O, Beyer S, Müller R (2003)

J. Biotechnol. 106: 233-253DOI: 10.1016/j.jbiotec.2003.07.015

The leupyrrins: A structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum

Bode H, Irschik H, Wenzel S, Reichenbach H, Müller R, Höfle G (2003)

J. Nat. Prod. 66 (9): 1203-1206DOI: 10.1021/np030109v

Possibility of bacterial recruitment of plant genes associated with the biosynthesis of secondary metabolites

Bode H, Müller R (2003)

Plant Physiol. 132 (3): 1153-1161DOI: 10.1104/pp.102.019760.

Steroid biosynthesis in prokaryotes: identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)-oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca

Bode H, Zeggel B, Silakowski B, Wenzel S, Reichenbach H, Müller R (2003)

Mol. Microbiol. 47 (2): 471-481DOI: 10.1046/j.1365-2958.2003.03309.x

2002

A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteria

Mahmud T, Bode H, Silakowski B, Kroppenstedt R, Xu M, Nordhoff S, Höfle G, Müller R (2002)

J. Biol. Chem. 277 (36): 32768-74DOI: 10.1074/jbc.M205222200

The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase

Gaitatzis N, Silakowski B, Kunze B, Nordsiek G, Blöcker H, Höfle G, Müller R (2002)

J. Biol. Chem. 277 (15): 13082-13090DOI: 10.1074/jbc.M111738200

2001

In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases

Gaitatzis N, Kunze B, Müller R (2001)

Proc. Natl. Acad. Sci. USA 98 (20): 11136-11141DOI: 10.1073/pnas.201167098

The mtaA gene of the myxothiazol biosynthetic gene cluster from Stigmatella aurantiaca DW4/3-1 encodes a phosphopantetheinyl transferase that activates polyketide synthases and polypeptide synthetases

Gaitatzis N, Hans A, Müller R, Beyer S (2001)

J. Biochem. (Tokyo) 129 (1): 119-124

Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15

Silakowski B, Nordsiek G, Kunze B, Blöcker H, Müller R (2001)

Chem. Biol. 8 (1): 59-69DOI: 10.1016/S1074-5521(00)00056-9

Multiple hybrid polyketide synthase/non-ribosomal peptide synthetase gene clusters in the myxobacterium Stigmatella aurantiaca

Silakowski B, Kunze B, Müller R (2001)

Gene 275 (2): 233-240

Prof. Dr. Rolf Müller

Über

2024

Isolation of Fidaxomicin and Shunt Metabolites from Actinoplanes deccanensis

The Peptide Antibiotic Corramycin Adopts a β-Hairpin-like Structure and Is Inactivated by the Kinase ComG

Inhibitory effect of sorangicin A against mutant DNA-dependent RNA polymerase in the obligate intracellular bacterium Chlamydia trachomatis

Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence

Nitroxoline resistance is associated with significant fitness loss and diminishes in vivo virulence of Escherichia coli

Is Simultaneous Binding to DNA and Gyrase Important for the Antibacterial Activity of Cystobactamids?

New myxobacteria of the Myxococcaceae clade produce angiolams with antiparasitic activities

Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents

Mining the microbiota for antibiotics

Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins

2023

3D bioprinting ofE. coliMG1655 biofilms on human lung epithelial cells for building complexin vitroinfection models

Discovery and Characterization of a Myxobacterial Lanthipeptide with Unique Biosynthetic Features and Anti-inflammatory Activity

Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections

Molecular replacement for small-molecule crystal structure determination from X-ray and electron diffraction data with reduced resolution

Darobactine: eine neue Antibiotikaklasse in Entwicklung

ABC-HuMi: the Atlas of Biosynthetic Gene Clusters in the Human Microbiome

New Genetically Engineered Derivatives of Antibacterial Darobactins Underpin Their Potential for Antibiotic Development

Discovery and overproduction of novel highly bioactive pamamycins through transcriptional engineering of the biosynthetic gene cluster

Tartrolon sensing and detoxification by the Listeria monocytogenes timABR resistance operon

New Genetically Engineered Derivatives of Antibacterial Darobac-tins Underpin their Potential for Antibiotic Development

Inhibitors of the Elastase LasB for the treatment of Pseudomonas aeruginosa lung infections

Artificial intelligence for natural product drug discovery

Impact of Drug Administration Routes on the In Vivo Efficacy of the Natural Product Sorangicin a Using a Staphylococcus aureus Infection Model in Zebrafish Embryos

Optimization of Mass Spectrometry Imaging for Drug Metabolism and Distribution Studies in the Zebrafish Larvae Model: A Case Study with the Opioid Antagonist Naloxone

Revision of the Absolute Configurations of Chelocardin and Amidochelocardin

In Vitro Activity of Two Novel Antimicrobial Compounds on MDR-Resistant Clinical Isolates

The mycobacterial ImuA'-ImuB-DnaE2 mutasome: composition and recruitment in live cells

Quantification of Plasmodium falciparum HRP-2 as an alternative method to 3Hhypoxanthine incorporation to measure the parasite reduction ratio in vitro

Schatztruhe Menschliches Mikrobiom: Wie Naturstoffe Uns Beeinflus...: Ingenta Connect

The Disorazole Z Family of Highly Potent Anticancer Natural Products from Sorangium cellulosum: Structure, Bioactivity, Biosynthesis, and Heterologous Expression

Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis

Insights into the biosynthesis of icumazole, unveiling a distinctive family of crotonyl-CoA carboxylase/reductase

Engineered Biosynthesis of Complex Disorazol Polyketides in a Streamlined Burkholderia thailandensis

Genome-Guided Discovery of the Myxobacterial Thiolactone-Containing Sorangibactins

Evaluation of extraction methods for untargeted metabolomic studies for future applications in zebrafish larvae infection models

Structure Elucidation and Biosynthesis of Nannosterols A and B, Myxobacterial Sterols from Nannocystis sp. MNa10993

Sorangicin A Is Active against Chlamydia in Cell Culture, Explanted Fallopian Tubes, and Topical In Vivo Treatment

The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection

Identification of Compounds Preventing A. fumigatus Biofilm Formation by Inhibition of the Galactosaminogalactan Deacetylase Agd3

The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition

Fighting antibiotic resistance-strategies and (pre)clinical developments to find new antibacterials

Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization

2022

Total In Vitro Biosynthesis of the Thioamitide Thioholgamide and Investigation of the Pathway

Stereoselective Syntheses of Deuterated Pipecolic Acids as Tools to Investigate the Stereoselectivity of the Hydroxylase GetF

Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes

Crystal structure of natural product argyrin-D determined by 3D electron diffraction

Bursts in biosynthetic gene cluster transcription are accompanied by surges of natural compound production in the myxobacterium Sorangium sp

Persicamidines-Unprecedented Sesquarterpenoids with Potent Antiviral Bioactivity against Coronaviruses

Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape

Darobactins Exhibiting Superior Antibiotic Activity by Cryo-EM Structure Guided Biosynthetic Engineering

Current Developments in Antibiotic Discovery – Global Microbial Diversity as Source for Evolutionary Optimized Anti-infectives

Current Developments in Antibiotic Discovery – Global Microbial Diversity as Source for Evolutionary Optimized Anti-infectives

The inherent antibiotic activity of myxobacteria-derived autofluorescent outer membrane vesicles is switched on and off by light stimulation

Large-Scale Interlaboratory DI-FT-ICR MS Comparability Study Employing Various Systems

Total synthesis of Myxoprincomide, a secondary metabolite from Myxococcus xanthus

Pineapple Lectin AcmJRL binds SARS-CoV-2 Spike Protein in a carbohydrate-dependent fashion

The Glycan-Specificity of the Pineapple Lectin AcmJRL and its Carbohydrate-Dependent Binding of the SARS-CoV-2 Spike Protein

Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening

Expanding the Ajudazol Cytotoxin Scaffold: Insights from Genome Mining, Biosynthetic Investigations, and Novel Derivatives

Interference with lipoprotein maturation sensitizes methicillin-resistant Staphylococcus aureus to human group IIA secreted phospholipase A 2 and daptomycin

Natural products lysobactin and sorangicin A show in vitro activity against Mycobacterium abscessus complex

Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA

Pharmacology and early ADMET data of corallopyronin A, a natural product with macrofilaricidal anti-wolbachial activity in filarial nematodes

A novel tumor-targeting strain of Xenorhabdus stockiae exhibits potent biological activities

Discovery, Biosynthesis and Biological Activity of a Succinylated Myxochelin from the Myxobacterial strain MSr12020

Thiamyxins: Structure and Biosynthesis of Myxobacterial RNA-Virus Inhibitors

Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin

BusyBee Web: towards comprehensive and differential composition-based metagenomic binning

Screening of Natural Products and Small Molecules Uncovers Novel Coronavirus 1a/1b Frameshifting Inhibitors with Antiviral Properties

Systematic cross-biospecimen evaluation of DNA extraction kits for long- and short-read multi-metagenomic sequencing studies

Three New Stigmatellin Derivatives Reveal Biosynthetic Insights of Its Side Chain Decoration

Corallopyronin A: antimicrobial discovery to preclinical development

Corallococcus soli sp. Nov., a Soil Myxobacterium Isolated from Subtropical Climate, Chalus County, Iran, and Its Potential to Produce Secondary Metabolites

An Outer Membrane Vesicle-Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability

Transferring Microclusters of P. aeruginosa Biofilms to the Air-Liquid Interface of Bronchial Epithelial Cells for Repeated Deposition of Aerosolized Tobramycin

Synthesis and Biological Evaluation of Novel 2-Substituted Analogues of (–)-Pentenomycin I