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Dr. Mariia Nesterkina
Über
Mariia Nesterkina studierte Pharmazeutische Chemie an der Odesa Mechnikov National University in der Ukraine und schloss 2014 mit Auszeichnung (Honor’s degree) ab. Sie promovierte 2017 am Institute of Bioorganic Chemistry and Petrochemistry in Kyiv, Ukraine, und beschäftigte sich mit der Synthese und pharmakologischen Untersuchung neuartiger Terpenoid-Derivate mit antikonvulsiver, analgetischer und entzündungshemmender Wirkung. Seit 2019 ist sie Associate Professorin an der Odesа Polytechnic National University (Ukraine).
Im Jahr 2022 schloss sie sich der Gruppe von Prof. Anna Hirsch und Prof. Claus-Michael Lehr als Postdoktorandin am Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS), Abteilung für Wirkstoffdesign und Optimierung, sowie der Abteilung für Wirkstofftransport über Biologische Barrieren an. Ihre Forschungsinteressen konzentrieren sich auf Bioorganische/Medizinische Chemie sowie Arzneimittelabgabe.
Ihr eigenes Projekt mit dem Titel „Molekulare Mechanismen der transdermalen Penetration neuartiger Terpenoid-Prodrugs mit antiinfektiöser Aktivität“ erhielt finanzielle Unterstützung von der Alexander von Humboldt-Stiftung (Saarbrücken, Deutschland, 2023–2025). Sie arbeitet intensiv an innovativen Arzneimittelabgabesystemen für Hautanwendungen – thermotrope Flüssigkristalle. Das charakteristische Merkmal dieser Systeme ist ihre temperaturgesteuerte Schaltbarkeit der Wirkstofffreisetzung durch den Übergang in den Flüssigkristallzustand, abhängig von der Hauttemperatur.
Seit 2024 ist Nesterkina Habilitandin an der Universität des Saarlandes im Bereich Biopharmazie und Pharmazeutische Technologie.
2024
Behavioral and electrophysiological responses of the male medfly, Ceratitis capitata, to thymol and carvacrol ethers
Tabanca N, Cloonan K, Nesterkina M, Gill M, Montgomery W, Kravchenko I, Kendra P (2024)
Pest management scienceDOI: 10.1002/ps.8324
Synthesis and Structure of a Coordination Polymer of Ni(II) with 2-(4-Bromophenoxy)acetohydrazide
Martsynko ?, Nesterkina M, Finik ?, Tsymbaliuk K, Dyakonenko V, Shishkina S, Kravchenko I (2024)
Molbank 2024 (2)DOI: 10.3390/M1819
Design and evaluation of nanostructured lipid carrier of Bergenin isolated from Pentaclethra macrophylla for anti-inflammatory effect on lipopolysaccharide-induced inflammatory responses in macrophages
Nnamani P, Nwagwu C, Diovu E, Abonyi O, Nesterkina M, Neu T, Richter C, Loretz B, Lehr C (2024)
Eur J Pharm Biopharm 200DOI: 10.1016/j.ejpb.2024.114307
Thermotropic liquid crystals in drug delivery: A versatile carrier for controlled release
Nesterkina M, Kravchenko* I, Hirsch A, Lehr C (2024)
Eur. J. Pharm. Biopharm. 200DOI: 10.1016/j.ejpb.2024.114343
2023
Thermoresponsive cholesteric liquid-crystal systems doped with terpenoids as drug delivery systems for skin applications
Nesterkina M, Vashchenko O, Vashchenko P, Lisetski L, Kravchenko I, Hirsch A, Lehr C (2023)
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.VDOI: 10.1016/j.ejpb.2023.09.002
Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster
Nesterkina M, Bilokon S, Alieksieieva T, Kravchenko I, Hirsch A (2023)
Toxicol. Rep. 10DOI: 10.1016/j.toxrep.2023.02.009
2022
PHARMACOLOGICAL AND PHYSICO-CHEMICAL PROPERTIES OF COMPOSITIONS BASED ON BIOSURFACTANTS AND N-CONTAINING HETEROCYCLIC DERIVATIVES OF 1,4-NAPHTHOQUINONE
Polish N, Nesterkina M, Karkhut A, Marintsova N, Zhurakhivska L, Volianiuk K, Pokynbroda T, Kravchenko I, Karpenko E (2022)
J microb biotech food sci 12 (3)DOI: 10.55251/jmbfs.5956
(1 R ,2 S ,5 R )-5-Methyl-2-(propan-2-yl)cyclohexyl 4-amino-3-phenylbutanoate hydrochloride: Synthesis and anticonvulsant activity
Nesterkina M, Musatov V, Honcharova O, Kravchenko I (2022)
Open Chemistry 20 (1): 703-707DOI: 10.1515/chem-2022-0189
New Ketene Dithioacetals Generated from 2-Nitroperchlorobutadiene and Investigation of Their Antibacterial, Antifungal, Anticonvulsant and Antidepressant Activities
Aydinli S, Bulut E, Deniz N, Sayil C, Komarovska-Porokhnyavets O, Lubenets V, Zvarych V, Stasevych M, Nesterkina M, Kravchenko I (2022)
Chemistry & Biodiversity 19 (7)DOI: 10.1002/cbdv.202100931
2021
Synthesis and pharmacological evaluation of novel naphthoquinone derivatives containing 1,2,4-triazine and 1,2,4-triazole moieties of methylene blue on the surface of a "core–shell" type catalyst for the Fenton system
Polish N, Nesterkina M, Protunkevych M, Karkhut A, Marintsova N, Polovkovych S, IKravchenko I, Voskoboinik O, Kovalenko S, Karpenko O (2021)
Vopr. Khim. Khim. Tekhnol. (5): 97-104DOI: 10.32434/0321-4095-2021-138-5-97-104
Novel (‒)-carvone derivatives as potential anticonvulsant and analgesic agents
Nesterkina M, Barbalat D, Konovalova I, Shishkina S, Atakay M, Salih B, Kravchenko I (2021)
Natural product research 35 (23): 4978-4987DOI: 10.1080/14786419.2020.1756804
Simultaneous Complexation and Microextraction Using Verbenone Hydrazone as the Ligand with Slotted Quartz Tube-Flame Atomic Absorption Spectrometry (FAAS) for the Sensitive Determination of Copper
Özzeybek G, Borahan T, Nesterkina M, Kravchenko I, Bakirdere S (2021)
Analytical letters 54 (14): 2376-2386DOI: 10.1080/00032719.2020.1866594
Quantitative structure–activity relationship study on prolonged anticonvulsant activity of terpene derivatives in pentylenetetrazole test
Nesterkina M, Muratov V, Ognichenko L, Kravchenko I, Kuz’min V (2021)
Open Chemistry 19 (1): 1184-1192DOI: 10.1515/chem-2021-0108
Rheological Properties of Hyaluronic Acid Diluted Solutions as Components of Cosmetics
Svetlana Saitarly, Yuriy Pushkarev, Nesterkina M, Serhat Öztürk, Iryna Kravchenko (2021)
Biointerface Res Appl Chem 12 (2): 1907-1915DOI: 10.33263/BRIAC122.19071915
Terpenoid Hydrazones as Biomembrane Penetration Enhancers: FT-IR Spectroscopy and Fluorescence Probe Studies
Nesterkina M, Smola S, Rusakova N, Kravchenko I (2021)
Molecules (Basel, Switzerland) 27 (1)DOI: 10.3390/molecules27010206
2020
9,10-Anthraquinone Dithiocarbamates as Potential Pharmaceutical Substances with Pleiotropic Actions: Computerized Prediction of Biological Activity and Experimental Validation
Stasevich M, Zvarich V, Novikov V, Zagorodnyaya S, Povnitsa O, Chaika M, Nesterkina M, Kravchenko I, Druzhilovskii D, Poroikov V (2020)
Pharm Chem J 53 (10): 905-913DOI: 10.1007/s11094-020-02098-x
Phytochemical analysis and anti-inflammatory activity of Cladophora aegagropila extract
Aleksandrova A, Nesterkina M, Gvozdii S, Kravchenko I (2020)
J Herbmed Pharmacol 9 (1): 81-85DOI: 10.15171/jhp.2020.12
Design, synthesis and pharmacological profile of (−)-verbenone hydrazones
Nesterkina M, Barbalat D, Kravchenko I (2020)
Open Chemistry 18 (1): 943-950DOI: 10.1515/chem-2020-0103
Synthesis and Evaluation on Anticonvulsant and Antidepressant Activities of Naphthoquinone Derivatives Containing Pyrazole and Pyrimidine Fragments
Polish N, Nesterkina M, Marintsova N, Karkhut A, Kravchenko I, Novikov V, Khairulin A (2020)
ACSi 67 (3): 934-939DOI: 10.17344/acsi.2020.5938
Toxic effect and genotoxicity of carvacrol ethers in Drosophila melanogaster
Nesterkina M, Bilokon S, Alieksieieva T, Chebotar S, Kravchenko I (2020)
Mutat. Res. 821 (2)DOI: 10.1016/j.mrfmmm.2020.111713
QSAR models for analgesic activity prediction of terpenes and their derivatives
Nesterkina M, Ognichenko L, Shyrykalova A, Kravchenko I, Kuz’min V (2020)
Struct Chem 31 (3): 947-954DOI: 10.1007/s11224-019-01479-7
2-Propyl-N′-[1,7,7-trimethylbicyclo[2.2.1]hept-2-ylidene]pentanehydrazide
Nesterkina M, Barbalat D, Rakipov I, Kravchenko I (2020)
Molbank 2020 (4)DOI: 10.3390/M1164
2019
Anti-inflammatory and analgesic activity of ointment based on dense ginger extract (Zingiber officinale)
Kravchenko I, Eberle L, Nesterkina M, Kobernik A (2019)
J Herbmed Pharmacol 8 (2): 126-132DOI: 10.15171/jhp.2019.20
Pharmacotherapy of inflammatory process by ginger extract (Zingiber officinale) ointment
Kravchenko I, Eberle L, Nesterkina M, Kobernik A (2019)
J Herbmed Pharmacol 8 (2): 101-107DOI: 10.15171/jhp.2019.16
Analgesic and Anti-Inflammatory Activity of Vanillin Derivatives
Boiko Y, Nesterkina M, Shandra A, Kravchenko I (2019)
Pharm Chem J 53 (7): 650-654DOI: 10.1007/s11094-019-02056-2
Effect of esters based on terpenoids and GABA on fluidity of phospholipid membranes
Nesterkina M, Smola S, Kravchenko I (2019)
J. Liposome Res. 29 (3): 239-246DOI: 10.1080/08982104.2018.1538238
(2S,5R)-2-Isopropyl-5-methylcyclohexanone Hydrazones
Nesterkina M, Barbalat D, Zheltvay I, Rakipov I, Atakay M, Salih B, Kravchenko I (2019)
Molbank 2019 (2)DOI: 10.3390/M1062
2018
Repellent activity of monoterpenoid esters with neurotransmitter amino acids against yellow fever mosquito, Aedes aegypti
Nesterkina M, Bernier U, Tabanca N, Kravchenko I (2018)
Open Chemistry 16 (1): 95-98DOI: 10.1515/chem-2018-0015
The influence of monoterpenoids and phenol derivatives on Drosophila melanogaster viability
Nesterkina M, Bilokon S, Alieksieieva T, Chubyk I, Kravchenko I (2018)
Journal of Asia-Pacific Entomology 21 (3): 793-796DOI: 10.1016/j.aspen.2018.06.004
2017
Synthesis and Pharmacological Properties of Novel Esters Based on Monoterpenoids and Glycine
Nesterkina M, Kravchenko I (2017)
Pharmaceuticals (Basel, Switzerland) 10 (2)DOI: 10.3390/ph10020047
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 4-Aminobutyrate Hydrochloride
Nesterkina M, Shishkina S, Maltsev G, Rakipov I, Kravchenko I (2017)
Molbank 2017 (3)DOI: 10.3390/M956
2016
Synthesis and Anticonvulsant Activity of Menthyl γ-Aminobutyrate
Nesterkina M, Kravchenko I (2016)
Chem Nat Compd 52 (2): 237-239DOI: 10.1007/s10600-016-1604-9
Synthesis and Anticonvulsant Activity of New Calix[4]Arene Derivatives Containing Gamma-Aminobutyric Acid Moieties
Nesterkina M, Alekseeva E, Kravchenko I (2016)
Pharm Chem J 49 (12): 825-829DOI: 10.1007/s11094-016-1380-7
Synthesis and Pharmacological Properties of Novel Esters Based on Monocyclic Terpenes and GABA
Nesterkina M, Kravchenko I (2016)
Pharmaceuticals (Basel, Switzerland) 9 (2)DOI: 10.3390/ph9020032
Analgesic Activity of Novel GABA Esters after Transdermal Delivery
Nesterkina M, Kravchenko I (2016)
Nat. Prod. Commun. 11 (10)DOI: 10.1177/1934578X1601101001
2014
Synthesis, Physicochemical Properties, and Anticonvulsant Activity of the Gaba Complex with a Calix[4]Arene derivative
Nesterkina M, Alekseeva E, Kravchenko I (2014)
Pharm Chem J 48 (2): 82-84DOI: 10.1007/s11094-014-1052-4