Dr Mariia Nesterkina
About
Mariia Nesterkina studied Pharmaceutical Chemistry at Odesa Mechnikov National University in Ukraine, graduating with distinction (Honor’s degree) in 2014. She received her PhD from the Institute of Bioorganic Chemistry and Petrochemistry (Kyiv, Ukraine) in 2017 and worked at the synthesis and pharmacological investigation of novel terpenoid derivatives with anticonvulsant, analgesic and anti-inflammatory activity. Since 2019, she is Associate Professor at Odesа Polytechnic National University (Ukraine).
In 2022, she joined the group of Prof. Anna Hirsch and Prof. Claus-Michael Lehr as a postdoctoral researcher at Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Department of Drug Design and Optimization; Department of Drug Delivery across Biological Barriers. Her research interests are focused on Bioorganic/Medicinal Chemistry as well as Drug Delivery.
Her own project entitled “Molecular mechanisms of transdermal penetration of novel terpenoid prodrugs with anti-infective activity” received financial support from Alexander von Humboldt Foundation (Saarbrücken, Germany, 2023–2025).
She works extensively on innovative drug delivery system for skin applications – thermotropic liquid crystals. The distinctive feature of aforementioned systems is their temperature-induced switchability of drug release by transition to the liquid crystal state, depending on the skin temperature.
Since 2024, Nesterkina has been a habilitand at Saarland University in the area of Biopharmacy and Pharmaceutical Technology.
2024
Behavioral and electrophysiological responses of the male medfly, Ceratitis capitata, to thymol and carvacrol ethers
Tabanca N, Cloonan K, Nesterkina M, Gill M, Montgomery W, Kravchenko I, Kendra P (2024)
Pest management scienceDOI: 10.1002/ps.8324
Synthesis and Structure of a Coordination Polymer of Ni(II) with 2-(4-Bromophenoxy)acetohydrazide
Martsynko ?, Nesterkina M, Finik ?, Tsymbaliuk K, Dyakonenko V, Shishkina S, Kravchenko I (2024)
Molbank 2024 (2)DOI: 10.3390/M1819
Design and evaluation of nanostructured lipid carrier of Bergenin isolated from Pentaclethra macrophylla for anti-inflammatory effect on lipopolysaccharide-induced inflammatory responses in macrophages
Nnamani P, Nwagwu C, Diovu E, Abonyi O, Nesterkina M, Neu T, Richter C, Loretz B, Lehr C (2024)
Eur J Pharm Biopharm 200DOI: 10.1016/j.ejpb.2024.114307
Thermotropic liquid crystals in drug delivery: A versatile carrier for controlled release
Nesterkina M, Kravchenko* I, Hirsch A, Lehr C (2024)
Eur. J. Pharm. Biopharm. 200DOI: 10.1016/j.ejpb.2024.114343
2023
Thermoresponsive cholesteric liquid-crystal systems doped with terpenoids as drug delivery systems for skin applications
Nesterkina M, Vashchenko O, Vashchenko P, Lisetski L, Kravchenko I, Hirsch A, Lehr C (2023)
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.VDOI: 10.1016/j.ejpb.2023.09.002
Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster
Nesterkina M, Bilokon S, Alieksieieva T, Kravchenko I, Hirsch A (2023)
Toxicol. Rep. 10DOI: 10.1016/j.toxrep.2023.02.009
2022
PHARMACOLOGICAL AND PHYSICO-CHEMICAL PROPERTIES OF COMPOSITIONS BASED ON BIOSURFACTANTS AND N-CONTAINING HETEROCYCLIC DERIVATIVES OF 1,4-NAPHTHOQUINONE
Polish N, Nesterkina M, Karkhut A, Marintsova N, Zhurakhivska L, Volianiuk K, Pokynbroda T, Kravchenko I, Karpenko E (2022)
J microb biotech food sci 12 (3)DOI: 10.55251/jmbfs.5956
(1 R ,2 S ,5 R )-5-Methyl-2-(propan-2-yl)cyclohexyl 4-amino-3-phenylbutanoate hydrochloride: Synthesis and anticonvulsant activity
Nesterkina M, Musatov V, Honcharova O, Kravchenko I (2022)
Open Chemistry 20 (1): 703-707DOI: 10.1515/chem-2022-0189
New Ketene Dithioacetals Generated from 2-Nitroperchlorobutadiene and Investigation of Their Antibacterial, Antifungal, Anticonvulsant and Antidepressant Activities
Aydinli S, Bulut E, Deniz N, Sayil C, Komarovska-Porokhnyavets O, Lubenets V, Zvarych V, Stasevych M, Nesterkina M, Kravchenko I (2022)
Chemistry & Biodiversity 19 (7)DOI: 10.1002/cbdv.202100931
2021
Synthesis and pharmacological evaluation of novel naphthoquinone derivatives containing 1,2,4-triazine and 1,2,4-triazole moieties of methylene blue on the surface of a "core–shell" type catalyst for the Fenton system
Polish N, Nesterkina M, Protunkevych M, Karkhut A, Marintsova N, Polovkovych S, IKravchenko I, Voskoboinik O, Kovalenko S, Karpenko O (2021)
Vopr. Khim. Khim. Tekhnol. (5): 97-104DOI: 10.32434/0321-4095-2021-138-5-97-104
Novel (‒)-carvone derivatives as potential anticonvulsant and analgesic agents
Nesterkina M, Barbalat D, Konovalova I, Shishkina S, Atakay M, Salih B, Kravchenko I (2021)
Natural product research 35 (23): 4978-4987DOI: 10.1080/14786419.2020.1756804
Simultaneous Complexation and Microextraction Using Verbenone Hydrazone as the Ligand with Slotted Quartz Tube-Flame Atomic Absorption Spectrometry (FAAS) for the Sensitive Determination of Copper
Özzeybek G, Borahan T, Nesterkina M, Kravchenko I, Bakirdere S (2021)
Analytical letters 54 (14): 2376-2386DOI: 10.1080/00032719.2020.1866594
Quantitative structure–activity relationship study on prolonged anticonvulsant activity of terpene derivatives in pentylenetetrazole test
Nesterkina M, Muratov V, Ognichenko L, Kravchenko I, Kuz’min V (2021)
Open Chemistry 19 (1): 1184-1192DOI: 10.1515/chem-2021-0108
Rheological Properties of Hyaluronic Acid Diluted Solutions as Components of Cosmetics
Svetlana Saitarly, Yuriy Pushkarev, Nesterkina M, Serhat Öztürk, Iryna Kravchenko (2021)
Biointerface Res Appl Chem 12 (2): 1907-1915DOI: 10.33263/BRIAC122.19071915
Terpenoid Hydrazones as Biomembrane Penetration Enhancers: FT-IR Spectroscopy and Fluorescence Probe Studies
Nesterkina M, Smola S, Rusakova N, Kravchenko I (2021)
Molecules (Basel, Switzerland) 27 (1)DOI: 10.3390/molecules27010206
2020
9,10-Anthraquinone Dithiocarbamates as Potential Pharmaceutical Substances with Pleiotropic Actions: Computerized Prediction of Biological Activity and Experimental Validation
Stasevich M, Zvarich V, Novikov V, Zagorodnyaya S, Povnitsa O, Chaika M, Nesterkina M, Kravchenko I, Druzhilovskii D, Poroikov V (2020)
Pharm Chem J 53 (10): 905-913DOI: 10.1007/s11094-020-02098-x
Phytochemical analysis and anti-inflammatory activity of Cladophora aegagropila extract
Aleksandrova A, Nesterkina M, Gvozdii S, Kravchenko I (2020)
J Herbmed Pharmacol 9 (1): 81-85DOI: 10.15171/jhp.2020.12
Design, synthesis and pharmacological profile of (−)-verbenone hydrazones
Nesterkina M, Barbalat D, Kravchenko I (2020)
Open Chemistry 18 (1): 943-950DOI: 10.1515/chem-2020-0103
Synthesis and Evaluation on Anticonvulsant and Antidepressant Activities of Naphthoquinone Derivatives Containing Pyrazole and Pyrimidine Fragments
Polish N, Nesterkina M, Marintsova N, Karkhut A, Kravchenko I, Novikov V, Khairulin A (2020)
ACSi 67 (3): 934-939DOI: 10.17344/acsi.2020.5938
Toxic effect and genotoxicity of carvacrol ethers in Drosophila melanogaster
Nesterkina M, Bilokon S, Alieksieieva T, Chebotar S, Kravchenko I (2020)
Mutat. Res. 821 (2)DOI: 10.1016/j.mrfmmm.2020.111713
QSAR models for analgesic activity prediction of terpenes and their derivatives
Nesterkina M, Ognichenko L, Shyrykalova A, Kravchenko I, Kuz’min V (2020)
Struct Chem 31 (3): 947-954DOI: 10.1007/s11224-019-01479-7
2-Propyl-N′-[1,7,7-trimethylbicyclo[2.2.1]hept-2-ylidene]pentanehydrazide
Nesterkina M, Barbalat D, Rakipov I, Kravchenko I (2020)
Molbank 2020 (4)DOI: 10.3390/M1164
2019
Anti-inflammatory and analgesic activity of ointment based on dense ginger extract (Zingiber officinale)
Kravchenko I, Eberle L, Nesterkina M, Kobernik A (2019)
J Herbmed Pharmacol 8 (2): 126-132DOI: 10.15171/jhp.2019.20
Pharmacotherapy of inflammatory process by ginger extract (Zingiber officinale) ointment
Kravchenko I, Eberle L, Nesterkina M, Kobernik A (2019)
J Herbmed Pharmacol 8 (2): 101-107DOI: 10.15171/jhp.2019.16
Analgesic and Anti-Inflammatory Activity of Vanillin Derivatives
Boiko Y, Nesterkina M, Shandra A, Kravchenko I (2019)
Pharm Chem J 53 (7): 650-654DOI: 10.1007/s11094-019-02056-2
Effect of esters based on terpenoids and GABA on fluidity of phospholipid membranes
Nesterkina M, Smola S, Kravchenko I (2019)
J. Liposome Res. 29 (3): 239-246DOI: 10.1080/08982104.2018.1538238
(2S,5R)-2-Isopropyl-5-methylcyclohexanone Hydrazones
Nesterkina M, Barbalat D, Zheltvay I, Rakipov I, Atakay M, Salih B, Kravchenko I (2019)
Molbank 2019 (2)DOI: 10.3390/M1062
2018
Repellent activity of monoterpenoid esters with neurotransmitter amino acids against yellow fever mosquito, Aedes aegypti
Nesterkina M, Bernier U, Tabanca N, Kravchenko I (2018)
Open Chemistry 16 (1): 95-98DOI: 10.1515/chem-2018-0015
The influence of monoterpenoids and phenol derivatives on Drosophila melanogaster viability
Nesterkina M, Bilokon S, Alieksieieva T, Chubyk I, Kravchenko I (2018)
Journal of Asia-Pacific Entomology 21 (3): 793-796DOI: 10.1016/j.aspen.2018.06.004
2017
Synthesis and Pharmacological Properties of Novel Esters Based on Monoterpenoids and Glycine
Nesterkina M, Kravchenko I (2017)
Pharmaceuticals (Basel, Switzerland) 10 (2)DOI: 10.3390/ph10020047
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 4-Aminobutyrate Hydrochloride
Nesterkina M, Shishkina S, Maltsev G, Rakipov I, Kravchenko I (2017)
Molbank 2017 (3)DOI: 10.3390/M956
2016
Synthesis and Anticonvulsant Activity of Menthyl γ-Aminobutyrate
Nesterkina M, Kravchenko I (2016)
Chem Nat Compd 52 (2): 237-239DOI: 10.1007/s10600-016-1604-9
Synthesis and Anticonvulsant Activity of New Calix[4]Arene Derivatives Containing Gamma-Aminobutyric Acid Moieties
Nesterkina M, Alekseeva E, Kravchenko I (2016)
Pharm Chem J 49 (12): 825-829DOI: 10.1007/s11094-016-1380-7
Synthesis and Pharmacological Properties of Novel Esters Based on Monocyclic Terpenes and GABA
Nesterkina M, Kravchenko I (2016)
Pharmaceuticals (Basel, Switzerland) 9 (2)DOI: 10.3390/ph9020032
Analgesic Activity of Novel GABA Esters after Transdermal Delivery
Nesterkina M, Kravchenko I (2016)
Nat. Prod. Commun. 11 (10)DOI: 10.1177/1934578X1601101001
2014
Synthesis, Physicochemical Properties, and Anticonvulsant Activity of the Gaba Complex with a Calix[4]Arene derivative
Nesterkina M, Alekseeva E, Kravchenko I (2014)
Pharm Chem J 48 (2): 82-84DOI: 10.1007/s11094-014-1052-4