Dr. Daniel Krug
Über
2024
New myxobacteria of the Myxococcaceae clade produce angiolams with antiparasitic activities
Walesch S, Garcia R, Mahmoud A, Panter F, Bollenbach S, Mäser P, Kaiser M, Krug D, Müller R (2024)
Microbiology SpectrumDOI: 10.1128/spectrum.03689-23
2023
3D bioprinting ofE. coliMG1655 biofilms on human lung epithelial cells for building complexin vitroinfection models
Aliyazdi S, Frisch S, Hidalgo A, Frank N, Krug D, Müller R, Schaefer U, Vogt T, Loretz B, Lehr C (2023)
Biofabrication 15 (3)DOI: 10.1088/1758-5090/acd95e
New Genetically Engineered Derivatives of Antibacterial Darobactins Underpin Their Potential for Antibiotic Development
Seyfert C, Müller A, Walsh D, Birkelbach J, Kany A, Porten C, Yuan B, Krug D, Herrmann J, Marlovits T, Hirsch A, Müller R (2023)
J. Med. Chem.DOI: 10.1021/acs.jmedchem.3c01660
New Genetically Engineered Derivatives of Antibacterial Darobac-tins Underpin their Potential for Antibiotic Development
Seyfert C, Müller A, Walsh D, Birkelbach J, Kany A, Porten C, Yuan B, Krug D, Herrmann J, Marlovits T, Hirsch A, Müller R (2023)
BookDOI: 10.26434/chemrxiv-2023-24tmj
The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition
Koller T, Scheid U, Kösel T, Herrmann J, Krug D, Boshoff H, Beckert B, Evans J, Schlemmer J, Sloan B, …, Wilson D, Müller R (2023)
J. Am. Chem. Soc. 145 (2): 851-863DOI: 10.1021/jacs.2c08816
2022
Stereoselective Syntheses of Deuterated Pipecolic Acids as Tools to Investigate the Stereoselectivity of the Hydroxylase GetF
Neis N, Xie F, Krug D, Zhao H, Siebert A, Binz T, Fu C, Müller R, Kazmaier U (2022)
Liebigs Ann. 2022 (13)DOI: 10.1002/ejoc.202200162
Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes
Gavriilidou A, Kautsar S, Zaburannyi N, Krug D, Müller R, Medema M, Ziemert N (2022)
Nat. Microbiol. 7 (5): 726-735DOI: 10.1038/s41564-022-01110-2
Transferring Microclusters of P. aeruginosa Biofilms to the Air-Liquid Interface of Bronchial Epithelial Cells for Repeated Deposition of Aerosolized Tobramycin
Horstmann J, Laric A, Boese A, Yildiz D, Röhrig T, Empting M, Frank N, Krug D, Müller R, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2022)
ACS infectious diseases 8 (1): 137-149DOI: 10.1021/acsinfecdis.1c00444
Myxobacteria of the Cystobacterineae Suborder Are Producers of New Vitamin K2 Derived Myxoquinones
Panter F, Popoff A, Garcia R, Krug D, Müller R (2022)
Microorganisms 10 (3)DOI: 10.3390/microorganisms10030534
2021
Expanding the Scope of Detectable Microbial Natural Products by Complementary Analytical Methods and Cultivation Systems
Bader C, Haack P, Panter F, Krug D, Müller R (2021)
Journal of natural products 84 (2): 268-277DOI: 10.1021/acs.jnatprod.0c00942
2020
Leben und Überleben im Boden: Myxococcus xanthus ist Mikrobe des Jahres 2020
Volz C, Krug D, Müller R (2020)
Biol. Unserer Zeit 50 (6): 424-432DOI: 10.1002/biuz.202010721
Supercritical Fluid Extraction Enhances Discovery of Secondary Metabolites from Myxobacteria
Bader C, Neuber M, Panter F, Krug D, Müller R (2020)
Analytical chemistry 92 (23): 15403-15411DOI: 10.1021/acs.analchem.0c02995
Biosynthesis of Cittilins, Unusual Ribosomally Synthesized and Post-translationally Modified Peptides from Myxococcus xanthus
Hug J, Dastbaz J, Adam S, Revermann O, Koehnke J, Krug D, Müller R (2020)
ACS chemical biology 15 (8): 2221-2231DOI: 10.1021/acschembio.0c00430
Bacteria as genetically programmable producers of bioactive natural products
Hug J, Krug D, Müller R (2020)
Nat. rev. chem. 4 (4): 172-193DOI: 10.1038/s41570-020-0176-1
Myxobakterielle Naturstofffabriken
Krug D, Garcia R, Müller R (2020)
Biospektrum 26 (1): 32-36DOI: 10.1007/s12268-020-1334-1
2019
Production of a Dibrominated Aromatic Secondary Metabolite by a Planctomycete Implies Complex Interaction with a Macroalgal Host
Panter F, Garcia R, Thewes A, Zaburannyi N, Bunk B, Overmann J, Gutierrez M, Krug D, Müller R (2019)
ACS Chem. Biol. 14 (accepted // 12): 2713-2719DOI: 10.1021/acschembio.9b00641
Genome mining reveals uncommon alkylpyrones as type III PKS products from myxobacteria
Hug J, Panter F, Krug D, Müller R (2019)
J. Ind. Microbiol. Biotechnol. 46 (3-4): 319-334DOI: 10.1007/s10295-018-2105-6
Novel Methoxymethacrylate Natural Products Uncovered by Statistics-Based Mining of the Myxococcus fulvus Secondary Metabolome
Panter F, Krug D, Müller R (2019)
ACS Chem. Biol. 14 (1): 88-98DOI: 10.1021/acschembio.8b00948
2018
Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria
Panter F, Krug D, Baumann S, Müller R (2018)
Chem. Sci. 9 (21): 4898-4908DOI: 10.1039/C8SC01325J
Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria
Hoffmann T, Krug D, Bozkurt N, Duddela S, Jansen R, Garcia R, Gerth K, Steinmetz H, Müller R (2018)
Nat. Commun. 9 (1)DOI: 10.1038/s41467-018-03184-1
2016
Predicting the presence of uncommon elements in unknown biomolecules from isotope patterns
Meusel M, Hufsky F, Panter F, Krug D, Müller R, Böcker S (2016)
Anal. Chem. 88: 7556-7566DOI: 10.1021/acs.analchem.6b01015
2015
Two of a kind-The biosynthetic pathways of chlorotonil and anthracimycin
Jungmann K, Jansen R, Gerth K, Huch V, Krug D, Fenical W, Müller R (2015)
ACS Chem. Biol. 10 (11): 2480-2490DOI: 10.1021/acschembio.5b00523
2014
Improving natural products identification through targeted LC-MS/MS in an untargeted secondary metabolomics workflow
Hoffmann T, Krug D, Hüttel S, Müller R (2014)
Anal. Chem. 86 (21): 10780-10788DOI: 10.1021/ac502805w
Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products
Krug D, Müller R (2014)
Nat. Prod. Rep. 31 (6): 768-783DOI: 10.1039/c3np70127a
2012
Myxoprincomide: a natural product from Myxococcus xanthus discovered by comprehensive analysis of the secondary metabolome
Cortina N, Krug D, Plaza A, Revermann O, Müller R (2012)
Angew. Chem. Int. Ed. Engl. 51 (3): 811-816DOI: 10.1002/anie.201106305
2011
Identification and characterization of the althiomycin biosynthetic gene cluster in Myxococcus xanthus DK897
Cortina N, Revermann O, Krug D, Müller R (2011)
ChemBioChem 12 (9): 1411-1416DOI: 10.1002/cbic.201100154
2009
Genome mining in Sorangium cellulosum So ce56 - identification and characterization of the homologous electron transfer proteins of a myxobacterial cytochrome P450
Ewen K, Hannemann F, Khatri Y, Perlova O, Kappl R, Krug D, Hüttermann J, Müller R, Bernhardt R (2009)
J. Biol. Chem. 284 (42): 28590-28598DOI: 10.1074/jbc.M109.021717
Discovery of additional members of the tyrosine aminomutase enzyme family and the mutational analysis of CmdF
Krug D, Müller R (2009)
ChemBioChem 10 (4): 741-750DOI: 10.1002/cbic.200800748
2008
DKxanthene biosynthesis - understanding the basis for diversity-oriented synthesis in myxobacterial secondary metabolism
Meiser P, Weissman K, Bode H, Krug D, Dickschat J, Sandmann A, Müller R (2008)
Chem. Biol. 15 (8): 771-781DOI: 10.1016/j.chembiol.2008.06.005
Efficient mining of myxobacterial metabolite profiles enabled by liquid chromatography-electrospray ionization-time-of-flight mass spectrometry and compound-based principal component analysis
Krug D, Zurek G, Schneider B, Garcia R, Müller R (2008)
Anal. Chim. Acta 624 (1): 97-106DOI: 10.1016/j.aca.2008.06.036
Discovering the Hidden Secondary Metabolome of Myxococcus xanthus: a Study of Intraspecific Diversity
Krug D, Zurek G, Revermann O, Vos M, Velicer G, Müller R (2008)
Appl. Environ. Microbiol. 74 (10): 3058-3068DOI: 10.1128/AEM.02863-07
2007
Complete genome sequence of the myxobacterium Sorangium cellulosum
Schneiker S, Perlova O, Kaiser O, Gerth K, Alici A, Altmeyer M, Bartels D, Bekel T, Beyer S, Bode E, …, Pühler A, Müller R (2007)
Nat. Biotechnol. 25 (11): 1281-1289DOI: 10.1038/nbt1354
Mutasynthesis-derived myxalamids and origin of the isobutyryl-CoA starter unit of myxalamid B
Bode H, Meiser P, Klefisch T, Cortina N, Krug D, Göhring A, Schwär G, Mahmud T, Elnakady Y, Müller R (2007)
ChemBioChem 8 (17): 2139-2144DOI: 10.1002/cbic.200700401
Biosynthesis of (R)-beta-tyrosine and its incorporation into the highly cytotoxic chondramides produced by Chondromyces crocatus
Rachid S, Krug D, Weissman K, Müller R (2007)
J. Biol. Chem. 282 (30): 21810-21817DOI: 10.1074/jbc.M703439200
2006
Metabolic physiology of Pseudomonas putida for heterologous production of myxochromide
Stephan S, Heinzle E, Wenzel S, Krug D, Müller R, Wittmann C (2006)
Process Biochem. 41 (2006): 2146-2152DOI: 10.1016/j.procbio.2006.06.022
Reconstitution of myxothiazol biosynthetic gene cluster by Red/ET recombination and heterologous expression in Myxococcus xanthus
Perlova O, Fu J, Kuhlmann S, Krug D, Stewart F, Zhang Y, Müller R (2006)
Appl. Environ. Microbiol. 72 (12): 7485-7494DOI: 10.1128/AEM.01503-06
Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis
Berner M, Krug D, Bihlmaier C, Vente A, Müller R, Bechthold A (2006)
J. Bacteriol. 188 (7): 2666-2673DOI: 10.1128/JB.188.7.2666–2673.2006
Myxovirescin biosynthesis is directed by hybrid polyketide synthases/ nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl CoA synthases and trans-acting acyltransferases
Simunovic V, Zapp J, Rachid S, Krug D, Meiser P, Müller R (2006)
ChemBioChem 7 (8): 1206-1220DOI: 10.1002/cbic.200600075
Molecular and biochemical studies of chondramide formation - highly cytotoxic natural products from Chondromyces crocatus Cm c5
Rachid S, Krug D, Kochems I, Kunze B, Scharfe M, Blöcker H, Zabriski M, Müller R (2006)
Chem. Biol. 14: 667-681DOI: 10.1016/j.chembiol.2006.06.002