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Dr Daniel Krug

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2022

Myxobacteria of the Cystobacterineae Suborder Are Producers of New Vitamin K2 Derived Myxoquinones

Panter F, Popoff A, Garcia R, Krug D, Müller R (2022)

Microorganisms 10 (3)DOI: 10.3390/microorganisms10030534

2021

Expanding the Scope of Detectable Microbial Natural Products by Complementary Analytical Methods and Cultivation Systems

Bader C, Haack P, Panter F, Krug D, Müller R (2021)

Journal of natural products 84 (2): 268-277DOI: 10.1021/acs.jnatprod.0c00942

2020

Leben und Überleben im Boden: Myxococcus xanthus ist Mikrobe des Jahres 2020

Volz C, Krug D, Müller R (2020)

Biol. Unserer Zeit 50 (6): 424-432DOI: 10.1002/biuz.202010721

Supercritical Fluid Extraction Enhances Discovery of Secondary Metabolites from Myxobacteria

Bader C, Neuber M, Panter F, Krug D, Müller R (2020)

Analytical chemistry 92 (23): 15403-15411DOI: 10.1021/acs.analchem.0c02995

Biosynthesis of Cittilins, Unusual Ribosomally Synthesized and Post-translationally Modified Peptides from Myxococcus xanthus

Hug J, Dastbaz J, Adam S, Revermann O, Koehnke J, Krug D, Müller R (2020)

ACS chemical biology 15 (8): 2221-2231DOI: 10.1021/acschembio.0c00430

Bacteria as genetically programmable producers of bioactive natural products

Hug J, Krug D, Müller R (2020)

Nat. rev. chem. 4 (4): 172-193DOI: 10.1038/s41570-020-0176-1

Myxobakterielle Naturstofffabriken

Krug D, Garcia R, Müller R (2020)

Biospektrum 26 (1): 32-36DOI: 10.1007/s12268-020-1334-1

2019

Production of a Dibrominated Aromatic Secondary Metabolite by a Planctomycete Implies Complex Interaction with a Macroalgal Host

Panter F, Garcia R, Thewes A, Zaburannyi N, Bunk B, Overmann J, Gutierrez M, Krug D, Müller R (2019)

ACS Chem. Biol. 14 (accepted // 12): 2713-2719DOI: 10.1021/acschembio.9b00641

Genome mining reveals uncommon alkylpyrones as type III PKS products from myxobacteria

Hug J, Panter F, Krug D, Müller R (2019)

J. Ind. Microbiol. Biotechnol. 46 (3-4): 319-334DOI: 10.1007/s10295-018-2105-6

Novel Methoxymethacrylate Natural Products Uncovered by Statistics-Based Mining of the Myxococcus fulvus Secondary Metabolome

Panter F, Krug D, Müller R (2019)

ACS Chem. Biol. 14 (1): 88-98DOI: 10.1021/acschembio.8b00948

2018

Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria

Panter F, Krug D, Baumann S, Müller R (2018)

Chem. Sci. 9 (21): 4898-4908DOI: 10.1039/C8SC01325J

Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria

Hoffmann T, Krug D, Bozkurt N, Duddela S, Jansen R, Garcia R, Gerth K, Steinmetz H, Müller R (2018)

Nat. Commun. 9 (1)DOI: 10.1038/s41467-018-03184-1

2016

Predicting the presence of uncommon elements in unknown biomolecules from isotope patterns

Meusel M, Hufsky F, Panter F, Krug D, Müller R, Böcker S (2016)

Anal. Chem. 88: 7556-7566DOI: 10.1021/acs.analchem.6b01015

2015

Two of a kind-The biosynthetic pathways of chlorotonil and anthracimycin

Jungmann K, Jansen R, Gerth K, Huch V, Krug D, Fenical W, Müller R (2015)

ACS Chem. Biol. 10 (11): 2480-2490DOI: 10.1021/acschembio.5b00523

2014

Improving natural products identification through targeted LC-MS/MS in an untargeted secondary metabolomics workflow

Hoffmann T, Krug D, Hüttel S, Müller R (2014)

Anal. Chem. 86 (21): 10780-10788DOI: 10.1021/ac502805w

Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products

Krug D, Müller R (2014)

Nat. Prod. Rep. 31 (6): 768-783DOI: 10.1039/c3np70127a

2012

Myxoprincomide: a natural product from Myxococcus xanthus discovered by comprehensive analysis of the secondary metabolome

Cortina N, Krug D, Plaza A, Revermann O, Müller R (2012)

Angew. Chem. Int. Ed. Engl. 51 (3): 811-816DOI: 10.1002/anie.201106305

2011

Identification and characterization of the althiomycin biosynthetic gene cluster in Myxococcus xanthus DK897

Cortina N, Revermann O, Krug D, Müller R (2011)

ChemBioChem 12 (9): 1411-1416DOI: 10.1002/cbic.201100154

2009

Genome mining in Sorangium cellulosum So ce56 - identification and characterization of the homologous electron transfer proteins of a myxobacterial cytochrome P450

Ewen K, Hannemann F, Khatri Y, Perlova O, Kappl R, Krug D, Hüttermann J, Müller R, Bernhardt R (2009)

J. Biol. Chem. 284 (42): 28590-28598DOI: 10.1074/jbc.M109.021717

Discovery of additional members of the tyrosine aminomutase enzyme family and the mutational analysis of CmdF

Krug D, Müller R (2009)

ChemBioChem 10 (4): 741-750DOI: 10.1002/cbic.200800748

2008

DKxanthene biosynthesis - understanding the basis for diversity-oriented synthesis in myxobacterial secondary metabolism

Meiser P, Weissman K, Bode H, Krug D, Dickschat J, Sandmann A, Müller R (2008)

Chem. Biol. 15 (8): 771-781DOI: 10.1016/j.chembiol.2008.06.005

Efficient mining of myxobacterial metabolite profiles enabled by liquid chromatography-electrospray ionization-time-of-flight mass spectrometry and compound-based principal component analysis

Krug D, Zurek G, Schneider B, Garcia R, Müller R (2008)

Anal. Chim. Acta 624 (1): 97-106DOI: 10.1016/j.aca.2008.06.036

Discovering the Hidden Secondary Metabolome of Myxococcus xanthus: a Study of Intraspecific Diversity

Krug D, Zurek G, Revermann O, Vos M, Velicer G, Müller R (2008)

Appl. Environ. Microbiol. 74 (10): 3058-3068DOI: 10.1128/AEM.02863-07

2007

Complete genome sequence of the myxobacterium Sorangium cellulosum

Schneiker S, Perlova O, Kaiser O, Gerth K, Alici A, Altmeyer M, Bartels D, Bekel T, Beyer S, Bode E, …, Pühler A, Müller R (2007)

Nat. Biotechnol. 25 (11): 1281-1289DOI: 10.1038/nbt1354

Mutasynthesis-derived myxalamids and origin of the isobutyryl-CoA starter unit of myxalamid B

Bode H, Meiser P, Klefisch T, Cortina N, Krug D, Göhring A, Schwär G, Mahmud T, Elnakady Y, Müller R (2007)

ChemBioChem 8 (17): 2139-2144DOI: 10.1002/cbic.200700401

Biosynthesis of (R)-beta-tyrosine and its incorporation into the highly cytotoxic chondramides produced by Chondromyces crocatus

Rachid S, Krug D, Weissman K, Müller R (2007)

J. Biol. Chem. 282 (30): 21810-21817DOI: 10.1074/jbc.M703439200

2006

Metabolic physiology of Pseudomonas putida for heterologous production of myxochromide

Stephan S, Heinzle E, Wenzel S, Krug D, Müller R, Wittmann C (2006)

Process Biochem. 41 (2006): 2146-2152DOI: 10.1016/j.procbio.2006.06.022

Reconstitution of myxothiazol biosynthetic gene cluster by Red/ET recombination and heterologous expression in Myxococcus xanthus

Perlova O, Fu J, Kuhlmann S, Krug D, Stewart F, Zhang Y, Müller R (2006)

Appl. Environ. Microbiol. 72 (12): 7485-7494DOI: 10.1128/AEM.01503-06

Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis

Berner M, Krug D, Bihlmaier C, Vente A, Müller R, Bechthold A (2006)

J. Bacteriol. 188 (7): 2666-2673DOI: 10.1128/JB.188.7.2666–2673.2006

Myxovirescin biosynthesis is directed by hybrid polyketide synthases/ nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl CoA synthases and trans-acting acyltransferases

Simunovic V, Zapp J, Rachid S, Krug D, Meiser P, Müller R (2006)

ChemBioChem 7 (8): 1206-1220DOI: 10.1002/cbic.200600075

Molecular and biochemical studies of chondramide formation - highly cytotoxic natural products from Chondromyces crocatus Cm c5

Rachid S, Krug D, Kochems I, Kunze B, Scharfe M, Blöcker H, Zabriski M, Müller R (2006)

Chem. Biol. 14: 667-681DOI: 10.1016/j.chembiol.2006.06.002