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Anti-Infectives from Microbiota

Prof Dr Christine Beemelmanns

The spread of antibiotic-resistant human pathogenic microorganisms poses an increasing threat to human health, and the development of new anti-infective agents and a better understanding of their function and mode of action is urgently needed. Our department pursues a microbiota-based strategy to identify new active substances from microorganisms.

Our research and approach

The group of Prof. Christine Beemelmanns focuses on the identification and functional analysis of novel anti-infective natural products from microbial communities. Co-cultivation studies as well as cell-based assays in combination with chemical-analytical and molecular-biological methods are used to evaluate and prioritize novel natural product producers. The group uses established and innovative metabolomic-, activity and genome-based methods to identify and determine the structure of the secreted natural products. Based on the isolated novel natural substances, the functional analysis and evaluation of their range of effects is carried out.

Team members

Research projects

What does "microbiota" mean?

Microbial communities (microbiota) are composed of a large number of different bacteria, fungi and representatives of unicellular and few-celled eukaryotes, as well as viruses. Microbiota are found, among other things, on human, animal and plant tissue surfaces, where they can assume essential functions for the host. In many cases, the composition of the microbiota correlates with its localization and thus its function.

What role do natural substances play?

Microorganisms regulate and manipulate their coexistence by emitting bioactive natural substances. Microbial natural products can act as antibiotics to protect producers, but can also act as a cellular signal, act as a morphogen for the host organism, or being metabolized as a nutrient. However, the chemical structures of many of these modulating natural substances are unknown, and their natural function, as well as their influence on the microbiota and possible application potentials are only very little known to date.

How can we harvest the biosynthetic potential of microorganisms? 

Since natural products play important roles in microbial interactions, their production is closely linked to the composition of the microbiota. The Beemelmanns group analyzes representative microbial communities to unlock this chemical space.

Target-oriented bioassays based on bacteria-bacteria and bacteria-fungus interaction studies are being used to stimulate the production of bioactive natural products. The group uses established and innovative analytical methods to elucidate the structure of the secreted natural substances.

The resulting natural products are synthesized for their anti-infective mode of action and natural products with high potency to better understand their structure-activity relationships and advance the profiling of the most promising candidates. In addition, the influence of the characterized natural substances on symbiotic communities is investigated using microbiome studies. With the help of these studies, we hope to be able to make better statements about the stability and dynamics of microbial communities. The elucidation of the biosynthetic pathways of new natural products and their regulation is also an important part of our research in order to improve our biocatalytic understanding and advance the development of biotechnological approaches.

Members of the department have different scientific educational backgrounds, which includes analytical and synthetic chemistry as well as microbiology, biochemistry and pharmacy.

How can we harvest the biosynthetic potential of microorganisms?

Since natural products play important roles in microbial interactions, their production is closely linked to the composition of the microbiota. The Beemelmanns group analyzes representative microbial communities to unlock this chemical space.

Target-oriented bioassays based on bacteria-bacteria and bacteria-fungus interaction studies are being used to stimulate the production of bioactive natural products. The group uses established and innovative analytical methods to elucidate the structure of the secreted natural substances.

The resulting natural products are synthesized for their anti-infective mode of action and natural products with high potency to better understand their structure-activity relationships and advance the profiling of the most promising candidates. In addition, the influence of the characterized natural substances on symbiotic communities is investigated using microbiome studies. With the help of these studies, we hope to be able to make better statements about the stability and dynamics of microbial communities. The elucidation of the biosynthetic pathways of new natural products and their regulation is also an important part of our research in order to improve our biocatalytic understanding and advance the development of biotechnological approaches.

Members of the department have different scientific educational backgrounds, which includes analytical and synthetic chemistry as well as microbiology, biochemistry and pharmacy.

Publications

2022

The chemical ecology of the fungus-farming termite symbiosis

Schmidt S, Kildgaard S, Guo H, Beemelmanns C, Poulsen M (2022)

Nat. Prod. Rep. 39 (2): 231-248DOI: 10.1039/d1np00022e

A Modular Approach to the Antifungal Sphingofungin Family: Concise Total Synthesis of Sphingofungin A and C

Raguž L, Peng C, Kaiser M, Görls H, Beemelmanns C (2022)

Angewandte Chemie (International ed. in English) 61 (5)DOI: 10.1002/anie.202112616

Structural and Functional Analysis of Bacterial Sulfonosphingolipids and Rosette-Inducing Factor 2 (RIF-2) by Mass Spectrometry-Guided Isolation and Total Synthesis

Leichnitz D, Peng C, Raguž L, Rutaganira F, Jautzus T, Regestein L, King N, Beemelmanns C (2022)

Chem. Eur. J. 28 (8)DOI: 10.1002/chem.202103883

Signalling molecules inducing metamorphosis in marine organisms

Rischer M, Guo H, Beemelmanns C (2022)

Nat. Prod. Rep. 39 (9): 1833-1855DOI: 10.1039/d1np00073j

Application of pyrrolo-protected amino aldehydes in the stereoselective synthesis of anti-1,2-amino alcohols

Sauer M, Beemelmanns C (2022)

Chemical communications (Cambridge, England) 58 (64): 8990-8993DOI: 10.1039/d2cc02317b

Identification of the new prenyltransferase Ubi-297 from marine bacteria and elucidation of its substrate specificity

Amiri Moghaddam J, Guo H, Willing K, Wichard T, Beemelmanns C (2022)

Beilstein journal of organic chemistry 18: 722-731DOI: 10.3762/bjoc.18.72

GNPS-Guided Discovery of Madurastatin Siderophores from the Termite-Associated Actinomadura sp. RB99

Lee S, Schalk F, Schwitalla J, Guo H, Yu J, Song M, Jung W, Beer Z, Beemelmanns C, Kim K (2022)

Chem. Eur. J. 28 (36)DOI: 10.1002/chem.202200612

Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition

Hoefgen S, Bissell A, Huang Y, Gherlone F, Raguž L, Beemelmanns C, Valiante V (2022)

Microbiology Spectrum 10 (5)DOI: 10.1128/spectrum.01331-22

Insights into the Metabolomic Capacity of Podaxis and Isolation of Podaxisterols A-D, Ergosterol Derivatives Carrying Nitrosyl Cyanide-Derived Modifications

Guo H, Daniel J, Seibel E, Burkhardt I, Conlon B, Görls H, Vassão D, Dickschat J, Poulsen M, Beemelmanns C (2022)

Journal of natural products 85 (9): 2159-2167DOI: 10.1021/acs.jnatprod.2c00380

Synthesis of Functionalized δ-Hydroxy-β-keto Esters and Evaluation of Their Anti-inflammatory Properties

Grosse M, Günther K, Jordan P, Roman D, Werz O, Beemelmanns C (2022)

Chembiochem : a European journal of chemical biology 23 (9)DOI: 10.1002/cbic.202200073

Biosynthesis of the Sphingolipid Inhibitors Sphingofungins in Filamentous Fungi Requires Aminomalonate as a Metabolic Precursor

Bissell A, Rautschek J, Hoefgen S, Raguž L, Mattern D, Saeed N, Janevska S, Jojic K, Huang Y, Kufs J, …, Beemelmanns C, Valiante V (2022)

ACS chemical biology 17 (2): 386-394DOI: 10.1021/acschembio.1c00839

Total Synthesis and Functional Evaluation of IORs, Sulfonolipid-based Inhibitors of Cell Differentiation in Salpingoeca rosetta

Raguž L, Peng C, Rutaganira F, Krüger T, Stanišic A, Jautzus T, Kries H, Kniemeyer O, Brakhage A, King N, Beemelmanns C (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202209105

2021

Species- and Caste-Specific Gut Metabolomes in Fungus-Farming Termites

Vidkjær N, Schmidt S, Hu H, Bodawatta K, Beemelmanns C, Poulsen M (2021)

Metabolites 11 (12)DOI: 10.3390/metabo11120839

Targeted Isolation of Saalfelduracin B-D from Amycolatopsis saalfeldensis Using LC-MS/MS-Based Molecular Networking

Um S, Seibel E, Schalk F, Balluff S, Beemelmanns C (2021)

Journal of natural products 84 (4): 1002-1011DOI: 10.1021/acs.jnatprod.0c01027

Comparative Genomic and Metabolic Analysis of Streptomyces sp. RB110 Morphotypes Illuminates Genomic Rearrangements and Formation of a New 46-Membered Antimicrobial Macrolide

Um S, Guo H, Thiengmag S, Benndorf R, Murphy R, Rischer M, Braga D, Poulsen M, Beer Z, Lackner G, Beemelmanns C (2021)

ACS chemical biology 16 (8): 1482-1492DOI: 10.1021/acschembio.1c00357

A community resource for paired genomic and metabolomic data mining

Schorn M, Verhoeven S, Ridder L, Huber F, Acharya D, Aksenov A, Aleti G, Moghaddam J, Aron A, Aziz S, …, Medema M, van der Hooft J (2021)

Nat Chem Biol 17 (4): 363-368DOI: 10.1038/s41589-020-00724-z

The Termite Fungal Cultivar Termitomyces Combines Diverse Enzymes and Oxidative Reactions for Plant Biomass Conversion

Schalk F, Gostincar C, Kreuzenbeck N, Conlon B, Sommerwerk E, Rabe P, Burkhardt I, Krüger T, Kniemeyer O, Brakhage A, …, Poulsen M, Beemelmanns C (2021)

mBio 12 (3)DOI: 10.1128/mBio.03551-20

GNPS-guided discovery of xylacremolide C and D, evaluation of their putative biosynthetic origin and bioactivity studies of xylacremolide A and B

Schalk F, Fricke J, Um S, Conlon B, Maus H, Jäger N, Heinzel T, Schirmeister T, Poulsen M, Beemelmanns C (2021)

RSC Adv 11 (31): 18748-18756DOI: 10.1039/d1ra00997d

Applications of the Horner–Wadsworth–Emmons Olefination in Modern Natural Product Synthesis

Roman D, Sauer M, Beemelmanns C (2021)

Synthesis 53 (16): 2713-2739DOI: 10.1055/a-1493-6331

Comparative Genomics Reveals Prophylactic and Catabolic Capabilities of Actinobacteria within the Fungus-Farming Termite Symbiosis

Murphy R, Benndorf R, Beer Z, Vollmers J, Kaster A, Beemelmanns C, Poulsen M (2021)

mSphere 6 (2)DOI: 10.1128/mSphere.01233-20

An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness

Marfil-Sánchez A, Zhang L, Alonso-Pernas P, Mirhakkak M, Mueller M, Seelbinder B, Ni Y, Santhanam R, Busch A, Beemelmanns C, …, Bauer M, Panagiotou G (2021)

Gut microbes 13 (1)DOI: 10.1080/19490976.2021.1993598

DAnIEL: A User-Friendly Web Server for Fungal ITS Amplicon Sequencing Data

Loos D, Zhang L, Beemelmanns C, Kurzai O, Panagiotou G (2021)

Frontiers in microbiology 12DOI: 10.3389/fmicb.2021.720513

Two Distinct Bacterial Biofilm Components Trigger Metamorphosis in the Colonial Hydrozoan Hydractinia echinata

Guo H, Rischer M, Westermann M, Beemelmanns C (2021)

mBio 12 (3)DOI: 10.1128/mBio.00401-21

Intra and extracellular effects of benzo α pyrene on liver, gill and blood of Caspian White fish (Rutilus frissi kutum): Cyto-genotoxicity and histopathology approach

Esmaeilbeigi M, Kalbassi M, Seyedi J, Tayemeh M, Moghaddam J (2021)

Marine pollution bulletin 163DOI: 10.1016/j.marpolbul.2020.111942

Revised structural assignment of azalomycins based on genomic and chemical analysis

Lee S, Guo H, Yu J, Park M, Dahse H, Jung W, Beemelmanns C, Kim K (2021)

Org. Chem. Front. 8 (17): 4791-4798DOI: 10.1039/D1QO00610J

Genome reduction and relaxed selection is associated with the transition to symbiosis in the basidiomycete genus Podaxis

Conlon B, Gostincar C, Fricke J, Kreuzenbeck N, Daniel J, Schlosser M, Peereboom N, Aanen D, Beer Z, Beemelmanns C, Gunde-Cimerman N, Poulsen M (2021)

iScience 24 (6)DOI: 10.1016/j.isci.2021.102680

Recent highlights of biosynthetic studies on marine natural products

Amiri Moghaddam J, Jautzus T, Alanjary M, Beemelmanns C (2021)

Org. Biomol. Chem. 19 (1): 123-140DOI: 10.1039/d0ob01677b

2020

Streptomyces smaragdinus sp. nov., isolated from the gut of the fungus growing-termite Macrotermes natalensis

Schwitalla J, Benndorf R, Martin K, Vollmers J, Kaster A, Beer Z, Poulsen M, Beemelmanns C (2020)

Int J Syst Evol Microbiol 70 (11): 5806-5811DOI: 10.1099/ijsem.0.004478

Targeted Discovery of Tetrapeptides and Cyclic Polyketide-Peptide Hybrids from a Fungal Antagonist of Farming Termites

Schalk F, Um S, Guo H, Kreuzenbeck N, Görls H, Beer Z, Beemelmanns C (2020)

Chembiochem : a European journal of chemical biology 21 (20): 2991-2996DOI: 10.1002/cbic.202000331

Modular Solid-Phase Synthesis of Antiprotozoal Barnesin Derivatives

Roman D, Raguž L, Keiff F, Meyer F, Barthels F, Schirmeister T, Kloss F, Beemelmanns C (2020)

Org. Lett. 22 (10): 3744-3748DOI: 10.1021/acs.orglett.0c00723

Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99

Rak Lee S, Schalk F, Schwitalla J, Benndorf R, Vollmers J, Kaster A, Beer Z, Park M, Ahn M, Jung W, Beemelmanns C, Kim K (2020)

Journal of natural products 83 (10): 3102-3110DOI: 10.1021/acs.jnatprod.0c00676

Anti-adipogenic Pregnane Steroid from a Hydractinia-associated Fungus, Cladosporium sphaerospermum SW67

Lee S, Kang H, Yoo M, Yu J, Lee S, Yi S, Beemelmanns C, Lee J, Kim K (2020)

Natural Product Sciences 26 (3): 230-235DOI: 10.20307/nps.2020.26.3.230

Structure elucidation of the redox cofactor mycofactocin reveals oligo-glycosylation by MftF

Peña-Ortiz L, Graça A, Guo H, Braga D, Köllner T, Regestein L, Beemelmanns C, Lackner G (2020)

Chem. Sci. 11 (20): 5182-5190DOI: 10.1039/d0sc01172j

From Persian Gulf to Indonesia: interrelated phylogeographic distance and chemistry within the genus Peronia (Onchidiidae, Gastropoda, Mollusca)

Maniei F, Amiri Moghaddam J, Crüsemann M, Beemelmanns C, König G, Wägele H (2020)

Sci. Rep. 10 (1)DOI: 10.1038/s41598-020-69996-8

Absolute Configuration and Corrected NMR Assignment of 17-Hydroxycyclooctatin, a Fused 5-8-5 Tricyclic Diterpene

Lee S, Lee D, Park M, Lee J, Park H, Kang K, Kim C, Beemelmanns C, Kim K (2020)

Journal of natural products 83 (2): 354-361DOI: 10.1021/acs.jnatprod.9b00837

Xyloneside A: A New Glycosylated Incisterol Derivative from Xylaria sp. FB

Lee S, Kreuzenbeck N, Jang M, Oh T, Ko S, Ahn J, Beemelmanns C, Kim K (2020)

Chembiochem : a European journal of chemical biology 21 (16): 2253-2258DOI: 10.1002/cbic.202000065

Stereoselective Construction of ( E,Z )‐1,3‐Dienes and Its Application in Natural Product Synthesis

Hubert P, Seibel E, Beemelmanns C, Campagne J, Figueiredo R (2020)

Adv. Synth. Catal. 362 (24): 5532-5575DOI: 10.1002/adsc.202000730

Gene Cluster Activation in a Bacterial Symbiont Leads to Halogenated Angucyclic Maduralactomycins and Spirocyclic Actinospirols

Guo H, Schwitalla J, Benndorf R, Baunach M, Steinbeck C, Görls H, Beer Z, Regestein L, Beemelmanns C (2020)

Org. Lett. 22 (7): 2634-2638DOI: 10.1021/acs.orglett.0c00601

Immunomodulatory function of antimicrobial peptide EC-Hepcidin1 modulates the induction of inflammatory gene expression in primary cells of Caspian Trout (Salmo trutta caspius Kessler, 1877)

Ghodsi Z, Kalbassi M, Farzaneh P, Mobarez A, Beemelmanns C, Amiri Moghaddam J (2020)

Fish & shellfish immunology 104: 55-61DOI: 10.1016/j.fsi.2020.05.067

Nocardia macrotermitis sp. nov. and Nocardia aurantia sp. nov., isolated from the gut of the fungus-growing termite Macrotermes natalensis

Benndorf R, Schwitalla J, Martin K, Beer Z, Vollmers J, Kaster A, Poulsen M, Beemelmanns C (2020)

Int J Syst Evol Microbiol 70 (10): 5226-5234DOI: 10.1099/ijsem.0.004398

Actinomadura rubteroloni sp. nov. and Actinomadura macrotermitis sp. nov., isolated from the gut of the fungus growing-termite Macrotermes natalensis

Benndorf R, Martin K, Küfner M, Beer Z, Vollmers J, Kaster A, Beemelmanns C (2020)

Int J Syst Evol Microbiol 70 (10): 5255-5262DOI: 10.1099/ijsem.0.004403

2019

Fridamycin A, a Microbial Natural Product, Stimulates Glucose Uptake without Inducing Adipogenesis

Yoon S, Lee S, Hwang J, Benndorf R, Beemelmanns C, Chung S, Kim K (2019)

Nutrients 11 (4)DOI: 10.3390/nu11040765

Spirocyclic cladosporicin A and cladosporiumins I and J from a Hydractinia -associated Cladosporium sphaerospermum SW67

Rischer M, Lee S, Eom H, Park H, Vollmers J, Kaster A, Shin Y, Oh D, Kim K, Beemelmanns C (2019)

Org. Chem. Front. 6 (8): 1084-1093DOI: 10.1039/C8QO01104D

Ursprung und Funktionen der Sphingolipide

Raguz L, Beemelmanns C (2019)

Nachrichten aus der Chemie 67 (2): 66-70DOI: 10.1002/nadc.20194085913

Disease-free monoculture farming by fungus-growing termites

Otani S, Challinor V, Kreuzenbeck N, Kildgaard S, Krath Christensen S, Larsen L, Aanen D, Rasmussen S, Beemelmanns C, Poulsen M (2019)

Sci. Rep. 9 (1)DOI: 10.1038/s41598-019-45364-z

Stereoselective synthesis of unnatural (2S,3S)-6-hydroxy-4-sphingenine-containing sphingolipids

Leichnitz D, Pflanze S, Beemelmanns C (2019)

Org. Biomol. Chem. 17 (29): 6964-6969DOI: 10.1039/c9ob00990f

Hybrid Polyketides from a Hydractinia-Associated Cladosporium sphaerospermum SW67 and Their Putative Biosynthetic Origin

Lee S, Lee D, Eom H, Rischer M, Ko Y, Kang K, Kim C, Beemelmanns C, Kim K (2019)

Marine drugs 17 (11)DOI: 10.3390/md17110606

Beauvetetraones A–C, phomaligadione-derived polyketide dimers from the entomopathogenic fungus, Beauveria bassiana

Lee S, Küfner M, Park M, Jung W, Choi S, Beemelmanns C, Kim K (2019)

Org. Chem. Front. 6 (2): 162-166DOI: 10.1039/C8QO01009A

Efomycins K and L From a Termite-Associated Streptomyces sp. M56 and Their Putative Biosynthetic Origin

Klassen J, Lee S, Poulsen M, Beemelmanns C, Kim K (2019)

Frontiers in microbiology 10DOI: 10.3389/fmicb.2019.01739

Tropolone natural products

Guo H, Roman D, Beemelmanns C (2019)

Nat. Prod. Rep. 36 (8): 1137-1155DOI: 10.1039/c8np00078f

Reviewing the taxonomy of Podaxis: Opportunities for understanding extreme fungal lifestyles

Conlon B, Aanen D, Beemelmanns C, Beer Z, Fine Licht H, Gunde-Cimerman N, Schiøtt M, Poulsen M (2019)

Fungal Biology 123 (3): 183-187DOI: 10.1016/j.funbio.2019.01.001

Mechanistic characterization of three sesquiterpene synthases from the termite-associated fungus Termitomyces

Burkhardt I, Kreuzenbeck N, Beemelmanns C, Dickschat J (2019)

Org. Biomol. Chem. 17 (13): 3348-3355DOI: 10.1039/c8ob02744g

Metabolic Pathway Rerouting in Paraburkholderia rhizoxinica Evolved Long-Overlooked Derivatives of Coenzyme F420

Braga D, Last D, Hasan M, Guo H, Leichnitz D, Uzum Z, Richter I, Schalk F, Beemelmanns C, Hertweck C, Lackner G (2019)

ACS chemical biology 14 (9): 2088-2094DOI: 10.1021/acschembio.9b00605

Stereoselective Cascade Cyclizations with Samarium Diiodide to Tetracyclic Indolines: Precursors of Fluorostrychnines and Brucine

Beemelmanns C, Nitsch D, Bentz C, Reissig H (2019)

Chem. Eur. J. 25 (37): 8780-8789DOI: 10.1002/chem.201900087

2018

Role of Chemical Mediators in Aquatic Interactions across the Prokaryote-Eukaryote Boundary

Wichard T, Beemelmanns C (2018)

Journal of chemical ecology 44 (11): 1008-1021DOI: 10.1007/s10886-018-1004-7

Biosynthesis, Synthesis, and Activities of Barnesin A, a NRPS-PKS Hybrid Produced by an Anaerobic Epsilonproteobacterium

Rischer M, Raguž L, Guo H, Keiff F, Diekert G, Goris T, Beemelmanns C (2018)

ACS chemical biology 13 (8): 1990-1995DOI: 10.1021/acschembio.8b00445

The Inhibitory Effects of Cyclodepsipeptides from the Entomopathogenic Fungus Beauveria bassiana on Myofibroblast Differentiation in A549 Alveolar Epithelial Cells

Park Y, Lee S, Kim D, Yu J, Beemelmanns C, Chung K, Kim K (2018)

Molecules (Basel, Switzerland) 23 (10)DOI: 10.3390/molecules23102568

Chemical Identification of Isoflavonoids from a Termite-Associated Streptomyces sp. RB1 and Their Neuroprotective Effects in Murine Hippocampal HT22 Cell Line

Lee S, Song J, Song J, Ko H, Baek J, Trinh T, Beemelmanns C, Yamabe N, Kim K (2018)

International journal of molecular sciences 19 (9)DOI: 10.3390/ijms19092640

Natalenamides A⁻C, Cyclic Tripeptides from the Termite-Associated Actinomadura sp. RB99

Lee S, Lee D, Yu J, Benndorf R, Lee S, Lee D, Huh J, Beer Z, Kim Y, Beemelmanns C, Kang K, Kim K (2018)

Molecules (Basel, Switzerland) 23 (11)DOI: 10.3390/molecules23113003

Precursor-Directed Diversification of Cyclic Tetrapeptidic Pseudoxylallemycins

Guo H, Schmidt A, Stephan P, Raguž L, Braga D, Kaiser M, Dahse H, Weigel C, Lackner G, Beemelmanns C (2018)

Chembiochem : a European journal of chemical biology 19 (21): 2307-2311DOI: 10.1002/cbic.201800503

Expanding the Rubterolone Family: Intrinsic Reactivity and Directed Diversification of PKS-derived Pyrans

Guo H, Benndorf R, König S, Leichnitz D, Weigel C, Peschel G, Berthel P, Kaiser M, Steinbeck C, Werz O, Poulsen M, Beemelmanns C (2018)

Chem. Eur. J. 24 (44): 11319-11324DOI: 10.1002/chem.201802066

Iterative l-Tryptophan Methylation in Psilocybe Evolved by Subdomain Duplication

Blei F, Fricke J, Wick J, Slot J, Hoffmeister D (2018)

Chembiochem : a European journal of chemical biology 19 (20): 2160-2166DOI: 10.1002/cbic.201800336

Biocatalytic Production of Psilocybin and Derivatives in Tryptophan Synthase-Enhanced Reactions

Blei F, Baldeweg F, Fricke J, Hoffmeister D (2018)

Chem. Eur. J.DOI: 10.1002/chem.201801047

Natural Products from Actinobacteria Associated with Fungus-Growing Termites

Benndorf R, Guo H, Sommerwerk E, Weigel C, Garcia-Altares M, Martin K, Hu H, Küfner M, Beer Z, Poulsen M, Beemelmanns C (2018)

Antibiotics 7 (3)DOI: 10.3390/antibiotics7030083

2017

Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides

Wyche T, Ruzzini A, Beemelmanns C, Kim K, Klassen J, Cao S, Poulsen M, Bugni T, Currie C, Clardy J (2017)

Org. Lett. 19 (7): 1772-1775DOI: 10.1021/acs.orglett.7b00545

Bakterien-induzierte Morphogenese mariner Eukaryoten

Rischer M, Leichnitz D, Beemelmanns C (2017)

Biospektrum 23 (6): 634-637DOI: 10.1007/s12268-017-0848-7

Total synthesis and functional analysis of microbial signalling molecules

Leichnitz D, Raguž L, Beemelmanns C (2017)

Chem. Soc. Rev. 46 (20): 6330-6344DOI: 10.1039/c6cs00665e

Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata

Guo H, Rischer M, Sperfeld M, Weigel C, Menzel K, Clardy J, Beemelmanns C (2017)

Bioorg Med Chem 25 (22): 6088-6097DOI: 10.1016/j.bmc.2017.06.053

Isolation, Biosynthesis and Chemical Modifications of Rubterolones A-F: Rare Tropolone Alkaloids from Actinomadura sp. 5-2

Guo H, Benndorf R, Leichnitz D, Klassen J, Vollmers J, Görls H, Steinacker M, Weigel C, Dahse H, Kaster A, …, Poulsen M, Beemelmanns C (2017)

Chem. Eur. J. 23 (39): 9338-9345DOI: 10.1002/chem.201701005

Wie sich Bakterien schützen

Benndorf R, Leichnitz D, Rischer M, Beemelmanns C (2017)

Nachrichten aus der Chemie 65 (1): 21-25DOI: 10.1002/nadc.20174049020

Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39

Beemelmanns C, Ramadhar T, Kim K, Klassen J, Cao S, Wyche T, Hou Y, Poulsen M, Bugni T, Currie C, Clardy J (2017)

Org. Lett. 19 (5): 1000-1003DOI: 10.1021/acs.orglett.6b03831

2016

Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates

Woznica A, Cantley A, Beemelmanns C, Freinkman E, Clardy J, King N (2016)

Proc. Natl. Acad. Sci. U.S.A. 113 (28): 7894-9DOI: 10.1073/pnas.1605015113

Draft Genome Sequence of Shewanella sp. Strain P1-14-1, a Bacterial Inducer of Settlement and Morphogenesis in Larvae of the Marine Hydroid Hydractinia echinata

Rischer M, Klassen J, Wolf T, Guo H, Shelest E, Clardy J, Beemelmanns C (2016)

Genome announc. 4 (1)DOI: 10.1128/genomeA.00003-16

A New Diketopiperazine, Cyclo(D-trans-Hyp-L-Leu) from a Kenyan Bacterium Bacillus licheniformis LB 8CT

Lee S, Beemelmanns C, Tsuma L, Clardy J, Cao S, Kim K (2016)

Natural product communications 11 (4): 461-3

Termisoflavones A-C, Isoflavonoid Glycosides from Termite-Associated Streptomyces sp. RB1

Kang H, Lee D, Benndorf R, Jung W, Beemelmanns C, Kang K, Kim K (2016)

Journal of natural products 79 (12): 3072-3078DOI: 10.1021/acs.jnatprod.6b00738

Pseudoxylallemycins A-F, Cyclic Tetrapeptides with Rare Allenyl Modifications Isolated from Pseudoxylaria sp. X802: A Competitor of Fungus-Growing Termite Cultivars

Guo H, Kreuzenbeck N, Otani S, Garcia-Altares M, Dahse H, Weigel C, Aanen D, Hertweck C, Poulsen M, Beemelmanns C (2016)

Org. Lett. 18 (14): 3338-41DOI: 10.1021/acs.orglett.6b01437

Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates

Cantley A, Woznica A, Beemelmanns C, King N, Clardy J (2016)

J. Am. Chem. Soc. 138 (13): 4326-9DOI: 10.1021/jacs.6b01190

Natural products from microbes associated with insects

Beemelmanns C, Guo H, Rischer M, Poulsen M (2016)

Beilstein journal of organic chemistry 12: 314-27DOI: 10.3762/bjoc.12.34

2015

Draft Genome Sequences of Six Pseudoalteromonas Strains, P1-7a, P1-9, P1-13-1a, P1-16-1b, P1-25, and P1-26, Which Induce Larval Settlement and Metamorphosis in Hydractinia echinata

Klassen J, Wolf T, Rischer M, Guo H, Shelest E, Clardy J, Beemelmanns C (2015)

Genome announc. 3 (6)DOI: 10.1128/genomeA.01477-15

Genome Sequences of Three Pseudoalteromonas Strains (P1-8, P1-11, and P1-30), Isolated from the Marine Hydroid Hydractinia echinata

Klassen J, Rischer M, Wolf T, Guo H, Shelest E, Clardy J, Beemelmanns C (2015)

Genome announc. 3 (6)DOI: 10.1128/genomeA.01380-15

A new antibacterial octaketide and cytotoxic phenylethanoid glycosides from Pogostemon cablin (Blanco) Benth

Kim K, Beemelmanns C, Clardy J, Cao S (2015)

Bioorg Med Chem Lett 25 (14): 2834-6DOI: 10.1016/j.bmcl.2015.04.094

Strychnine as Target, Samarium Diiodide as Tool: A Personal Story

Beemelmanns C, Reissig H (2015)

Chemical record (New York, N.Y.) 15 (5): 872-85DOI: 10.1002/tcr.201500024

Evolution of a short route to strychnine by using the samarium-diiodide-induced cascade cyclization as a key step

Beemelmanns C, Reissig H (2015)

Chem. Eur. J. 21 (23): 8416-25DOI: 10.1002/chem.201500094

2014

Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery

Ramadhar T, Beemelmanns C, Currie C, Clardy J (2014)

J. Antibiot. 67 (1): 53-8DOI: 10.1038/ja.2013.77

Natalamycin A, an Ansamycin from a Termite-Associated Streptomyces sp

Kim K, Ramadhar T, Beemelmanns C, Cao S, Poulsen M, Currie C, Clardy J (2014)

Chem. Sci. 5 (11): 4333-4338DOI: 10.1039/C4SC01136H

Naphthalenones and Isocoumarins from a Costa Rican Fungus Xylariaceae sp. CR1546C

Kim K, Beemelmanns C, Murillo C, Guillén A, Umaña L, Tamayo-Castillo G, Kim S, Clardy J, Cao S (2014)

Journal of Chemical Research 38 (12): 722-725DOI: 10.3184/174751914X14175406270662

Synthesis of the rosette-inducing factor RIF-1 and analogs

Beemelmanns C, Woznica A, Alegado R, Cantley A, King N, Clardy J (2014)

J. Am. Chem. Soc. 136 (29): 10210-3DOI: 10.1021/ja5046692