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The role of mucus on drug transport and its potential to affect therapeutic outcomes
Publikation
Murgia X,
Loretz B,
Hartwig O,
Hittinger M,
Lehr C
(2018)
Advanced Drug Delivery Reviews, 124, 82-97, 10.1016/j.addr.2017.10.009, 29106910
Advanced Drug Delivery Reviews, 124, 82-97, 10.1016/j.addr.2017.10.009, 29106910
Directing Drugs to Bugs: Antibiotic-Carbohydrate Conjugates Targeting Biofilm-Associated Lectins of Pseudomonas aeruginosa
Publikation
Meiers J,
Zahorska E,
Röhrig T,
Hauck D,
Wagner S,
Titz A
(2020)
Journal of medicinal chemistry, 63, 20, 11707-11724, 10.1021/acs.jmedchem.0c00856, 32924479
Journal of medicinal chemistry, 63, 20, 11707-11724, 10.1021/acs.jmedchem.0c00856, 32924479
A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1
Publikation
van der Vlag R,
Guo H,
Hapko U,
Eleftheriadis N,
Monjas L,
Dekker F,
Hirsch A
(2019)
European journal of medicinal chemistry, 174, 45-55, 10.1016/j.ejmech.2019.04.021, 31026746
European journal of medicinal chemistry, 174, 45-55, 10.1016/j.ejmech.2019.04.021, 31026746
Epistatic Interactions in NS5A of Hepatitis C Virus Suggest Drug Resistance Mechanisms
Publikation
Knops E,
Sierra S,
Kalaghatgi P,
Heger E,
Kaiser R,
Kalinina O
(2018)
Genes, 9, 7, 10.3390/genes9070343, 29986475
Genes, 9, 7, 10.3390/genes9070343, 29986475
Design of Poly-Catechol Biodynamers for Potentiation of Antibiotic Efficacy against Drug-Resistant Bacteria
Publikation
Zeroug-Metz L,
Shehu K,
Bassil J,
Podlecki J,
Sonntag P,
Koch M,
Christoulaki A,
Buhler E,
Hirsch A,
Kraegeloh A,
Schneider M,
Lee S
(2026)
Biomacromolecules, 27, 3, 1949-1968, 10.1021/acs.biomac.5c02130, 41730198
Biomacromolecules, 27, 3, 1949-1968, 10.1021/acs.biomac.5c02130, 41730198
DVD-IgG1 antibody-drug conjugates: Expanding the landscape of targeted cancer therapy
Publikation
Kiefer A,
Steele A,
Rader C,
Shen B
(2026)
Current opinion in chemical biology, 92, 10.1016/j.cbpa.2026.102653, 41734646
Current opinion in chemical biology, 92, 10.1016/j.cbpa.2026.102653, 41734646
Targeting the Energy-Coupling Factor Transporters: A Novel Antibiotic Drug Target in Streptococcus pneumoniae
Publikation
Diamanti E,
Cremers A,
Li Y,
Exapicheidou I,
Baumann C,
Gibson P,
Shams A,
Martin L,
Becker R,
Setyawati I,
Zeimetz L,
Haupenthal J,
Witschel M,
Slotboom D,
Herrmann J,
Rox K,
Hamed M,
Veening J,
Hirsch A
(2026)
J. Med. Chem., 10.1021/acs.jmedchem.5c03638, 42284150
J. Med. Chem., 10.1021/acs.jmedchem.5c03638, 42284150
Raman microscopy for cellular investigations--From single cell imaging to drug carrier uptake visualization
Publikation
Kann B,
Offerhaus H,
Windbergs M,
Otto C
(2015)
Advanced Drug Delivery Reviews, 89, 71-90, 10.1016/j.addr.2015.02.006, 25728764
Advanced Drug Delivery Reviews, 89, 71-90, 10.1016/j.addr.2015.02.006, 25728764
The Non-Mevalonate Pathway to Isoprenoid Biosynthesis: A Potential Source of New Drug Targets
Publikation
Hirsch A,
Diederich F
(2008)
CHIMIA, 62, 4, 226-230, 10.2533/chimia.2008.226
CHIMIA, 62, 4, 226-230, 10.2533/chimia.2008.226
Human microbial metabolite mimicry as a strategy to expand the chemical space of potential drugs
Publikation
Li H,
Ranhotra H,
Mani S,
Dvorák Z,
Sokol H,
Müller R
(2020)
Drug Discov. Today, 25, 9, 1575-1579, 10.1016/j.drudis.2020.06.007, 32562605
Drug Discov. Today, 25, 9, 1575-1579, 10.1016/j.drudis.2020.06.007, 32562605