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Gesucht nach "drug". Zeige Ergebnisse 701 bis 710 von 712.

Point mutations in the ygiV promoter region lead to cystobactamid resistance and reduced virulence in E. coli

Publikation
Müller R, Risch T, Kolling D, Mostert D, Seedorf T, Heimann D, Kohnhäuser D, Deschner F, Fries F, Solga D, Hilgers J, Dastbaz J, Hirsch A, Brönstrup M, Kirschning A, Herrmann J, Sieber S (2024)
Book, 10.21203/rs.3.rs-3751821/v1

Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents

Publikation
Khalifa H, Rasheed S, Haupenthal J, Herrmann J, Mandour Y, Abadi A, Engel M, Müller R, Hirsch A, Abdel-Halim* M, Hamed* M (2024)
Archiv der Pharmazie, 10.1002/ardp.202300656, 38304944

Towards the sustainable discovery and development of new antibiotics

Publikation
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo P, Glaser P, Aigle B, Bode H, Moreira R, Li Y, Luzhetskyy A, Medema M, Pernodet J, Stadler M, Tormo J, Genilloud O, Truman A, Weissman K, Takano E, Sabatini S, Stegmann E, Brötz-Oesterhelt H, Wohlleben W, Seemann M, Empting M, Hirsch A, Loretz B, Lehr C, Titz A, Herrmann J, Jaeger T, Alt S, Hesterkamp T, Winterhalter M, Schiefer A, Pfarr K, Hoerauf A, Graz H, Graz M, Lindvall M, Ramurthy S, Karlén A, van Dongen M, Petkovic H, Keller A, Peyrane F, Donadio S, Fraisse L, Piddock L, Gilbert I, Moser H, Müller R (2021)
Nature reviews. Chemistry, 5, 10, 726-749, 10.1038/s41570-021-00313-1, 34426795

A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d -galactose pentaacetate

Publikation
Zahorska E, Kuhaudomlarp S, Minervini S, Yousaf S, Lepsik M, Kinsinger T, Hirsch A, Imberty A, Titz A (2020)
Chem. Commun., 56, 62, 8822-8825, 10.1039/d0cc03490h

Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters

Publikation
Kiefer A, Bousis S, Hamed M, Diamanti E, Haupenthal J, Hirsch A (2022)
J. Med. Chem., 10.1021/acs.jmedchem.1c02114

Innovative zinc-binding inhibitors of Legionella pneumophila ProA reduce collagen and flagellin degradation, TLR5 evasion, and human lung tissue inflammation

Publikation
Scheithauer L, Ornago C, Selmar J, Schütz C, Bianchi G, Kiefer A, Haupenthal J, Dellmann A, Huynh D, Zhang R, Blankenfeldt W, Hirsch A, Steinert M (2025)
European journal of medicinal chemistry, 296, 10.1016/j.ejmech.2025.117832, 40479898

Unlocking the Antiviral Arsenal: Structure-Guided Optimization of Small-Molecule Inhibitors against RSV and hCoV-229E

Publikation
Karhan C, Sake S, Gunesch A, Grethe C, Hellwinkel B, Köhler N, Kiefer A, Hapko U, Kany A, Pietschmann T, Hirsch A (2025)
European journal of medicinal chemistry, 10.1016/j.ejmech.2025.117282

Dual inhibitors of Pseudomonas aeruginosa virulence factors LecA and LasB

Publikation
Metelkina O, Konstantinovic J, Klein A, Shafiei R, Fares M, Alhayek A, Yahiaoui S, Elgaher W, Haupenthal J, Titz* A, Hirsch* A (2024)
Chem. Sci., 15, 10.1039/D4SC02703E

Dynamic Combinatorial Chemistry Unveils Nsp10 Inhibitors with Antiviral Potential Against SARS-CoV-2

Publikation
Jumde R, Jézéquel G, Saramago M, Frank N, Adam S, Cunha M, Bader C, Gunesch A, Köhler N, Johannsen S, Bousis S, Pietschmann T, Matos R, Müller R, Arraiano C, Hirsch A (2024)
Chem. - Eur. J., 10.1002/chem.202403390, 39676060

Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity

Publikation
Ropponen H, Bader C, Diamanti E, Illarionov B, Rottmann M, Fischer M, Witschel M, Müller R, Hirsch A (2021)
ChemMedChem, 16, 13, 2089-2093, 10.1002/cmdc.202100067, 33844432