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Gesucht nach "drug". Zeige Ergebnisse 701 bis 710 von 717.

Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections

Publikation
Konstantinovic J, Kany A, Alhayek A, Abdelsamie A, Sikandar A, Voos K, Yao Y, Andreas A, Shafiei R, Loretz B, Schönauer E, Bals R, Brandstetter H, Hartmann R, Ducho C, Lehr C, Beisswenger C, Müller R, Rox K, Haupenthal J, Hirsch A (2023)
ACS Cent. Sci., 9, 12, 2205-2215, 10.1021/acscentsci.3c01102, 38161367

Fighting antibiotic resistance-strategies and (pre)clinical developments to find new antibacterials

Publikation
Walesch S, Birkelbach J, Jézéquel G, Haeckl F, Hegemann J, Hesterkamp T, Hirsch A, Hammann P, Müller R (2023)
EMBO reports, 24, 1, 10.15252/embr.202256033, 36533629

Point mutations in the ygiV promoter region lead to cystobactamid resistance and reduced virulence in E. coli

Publikation
Müller R, Risch T, Kolling D, Mostert D, Seedorf T, Heimann D, Kohnhäuser D, Deschner F, Fries F, Solga D, Hilgers J, Dastbaz J, Hirsch A, Brönstrup M, Kirschning A, Herrmann J, Sieber S (2024)
Book, 10.21203/rs.3.rs-3751821/v1

Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents

Publikation
Khalifa H, Rasheed S, Haupenthal J, Herrmann J, Mandour Y, Abadi A, Engel M, Müller R, Hirsch A, Abdel-Halim* M, Hamed* M (2024)
Archiv der Pharmazie, 10.1002/ardp.202300656, 38304944

Genome Mining Guided Identification of the Metallophore Delftichelin A from Delftia deserti

Publikation
Kruijff M, Hiller L, Birkelbach J, Decker T, Götze S, Kochems R, Müller R, Hirsch A, Beemelmanns C (2026)
J. Nat. Prod., 10.1021/acs.jnatprod.6c00213

Advanced mutasynthesis studies on the natural α-pyrone antibiotic myxopyronin from Myxococcus fulvus

Publikation
Sahner J, Sucipto H, Wenzel S, Groh M, Hartmann R, Müller R (2015)
ChemBioChem, 16, 946-953, 10.1002/cbic.201402666, 25757034

Towards the sustainable discovery and development of new antibiotics

Publikation
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo P, Glaser P, Aigle B, Bode H, Moreira R, Li Y, Luzhetskyy A, Medema M, Pernodet J, Stadler M, Tormo J, Genilloud O, Truman A, Weissman K, Takano E, Sabatini S, Stegmann E, Brötz-Oesterhelt H, Wohlleben W, Seemann M, Empting M, Hirsch A, Loretz B, Lehr C, Titz A, Herrmann J, Jaeger T, Alt S, Hesterkamp T, Winterhalter M, Schiefer A, Pfarr K, Hoerauf A, Graz H, Graz M, Lindvall M, Ramurthy S, Karlén A, van Dongen M, Petkovic H, Keller A, Peyrane F, Donadio S, Fraisse L, Piddock L, Gilbert I, Moser H, Müller R (2021)
Nature reviews. Chemistry, 5, 10, 726-749, 10.1038/s41570-021-00313-1, 34426795

Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters

Publikation
Kiefer A, Bousis S, Hamed M, Diamanti E, Haupenthal J, Hirsch A (2022)
J. Med. Chem., 10.1021/acs.jmedchem.1c02114

A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d -galactose pentaacetate

Publikation
Zahorska E, Kuhaudomlarp S, Minervini S, Yousaf S, Lepsik M, Kinsinger T, Hirsch A, Imberty A, Titz A (2020)
Chem. Commun., 56, 62, 8822-8825, 10.1039/d0cc03490h

Dual inhibitors of Pseudomonas aeruginosa virulence factors LecA and LasB

Publikation
Metelkina O, Konstantinovic J, Klein A, Shafiei R, Fares M, Alhayek A, Yahiaoui S, Elgaher W, Haupenthal J, Titz* A, Hirsch* A (2024)
Chem. Sci., 15, 10.1039/D4SC02703E