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Gesucht nach "drug". Zeige Ergebnisse 641 bis 650 von 700.

Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain

Publikation
Gawriljuk V, Godoy A, Oerlemans R, Welker L, Hirsch A, Groves M (2024)
Nat. Commun., 15, 1, 10.1038/s41467-024-50671-9, 39103329

Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD

Publikation
Willocx D, D'Auria L, Walsh D, Scherer H, Alhayek A, Hamed M, Borel F, Diamanti E, Hirsch A (2024)
Angew. Chem., Int. Ed. Engl., 10.1002/anie.202414615, 39676054

Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE

Publikation
Braun-Cornejo M, Ornago C, Sonawane V, Haupenthal J, Kany A, Diamanti E, Jézéquel G, Reiling N, Blankenfeldt W, Maas P, Hirsch A (2024)
ACS omega, 10.1021/acsomega.4c05537

AI is a viable alternative to high throughput screening: a 318-target study

Publikation
Wallach I, Hirsch, Anna K. H. et al. (2024)
Sci. Rep., 14, 1, 10.1038/s41598-024-54655-z, 38565852

Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes

Publikation
Geißler A, Junca H, Kany A, Daumann L, Hirsch A, Pieper D, Sieber S (2024)
Chem. Sci., 15, 30, 11946-11955, 10.1039/D4SC01940G, 39092115

Overcoming the unexpected functional inversion of a PqsR antagonist in Pseudomonas aeruginosa: an in vivo potent antivirulence agent targeting pqs quorum sensing

Publikation
Lu C, Maurer C, Kirsch B, Steinbach A, Hartmann R (2014)
Angewandte Chemie (International ed. in English), 53, 4, 1109-12, 10.1002/anie.201307547, 24338917

Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry

Publikation
Mondal M, Radeva N, Köster H, Park A, Potamitis C, Zervou M, Klebe G, Hirsch A (2014)
Angewandte Chemie (International ed. in English), 53, 12, 3259-63, 10.1002/anie.201309682, 24532096

Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors

Publikation
Schmitt C, Kail D, Mariano M, Empting M, Weber N, Paul T, Hartmann R, Engel M (2014)
PLoS ONE, 9, 3, 10.1371/journal.pone.0087851, 24676346

A natural-product switch for a dynamic protein interface

Publikation
Scheepstra M, Nieto L, Hirsch A, Fuchs S, Leysen S, Lam C, het Panhuis L, van Boeckel C, Wienk H, Boelens R, Ottmann C, Milroy L, Brunsveld L (2014)
Angewandte Chemie (International ed. in English), 53, 25, 6443-8, 10.1002/anie.201403773, 24821627

Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker

Publikation
Abdelsamie A, Bey E, Hanke N, Empting M, Hartmann R, Frotscher M (2014)
European journal of medicinal chemistry, 82, 394-406, 10.1016/j.ejmech.2014.05.074, 24929290