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Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors
Publikation
Schmitt C,
Kail D,
Mariano M,
Empting M,
Weber N,
Paul T,
Hartmann R,
Engel M
(2014)
PLoS ONE, 9, 3, 10.1371/journal.pone.0087851, 24676346
PLoS ONE, 9, 3, 10.1371/journal.pone.0087851, 24676346
A natural-product switch for a dynamic protein interface
Publikation
Scheepstra M,
Nieto L,
Hirsch A,
Fuchs S,
Leysen S,
Lam C,
het Panhuis L,
van Boeckel C,
Wienk H,
Boelens R,
Ottmann C,
Milroy L,
Brunsveld L
(2014)
Angewandte Chemie (International ed. in English), 53, 25, 6443-8, 10.1002/anie.201403773, 24821627
Angewandte Chemie (International ed. in English), 53, 25, 6443-8, 10.1002/anie.201403773, 24821627
Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker
Publikation
Abdelsamie A,
Bey E,
Hanke N,
Empting M,
Hartmann R,
Frotscher M
(2014)
European journal of medicinal chemistry, 82, 394-406, 10.1016/j.ejmech.2014.05.074, 24929290
European journal of medicinal chemistry, 82, 394-406, 10.1016/j.ejmech.2014.05.074, 24929290
Theoretical and structural analysis of long C-C bonds in the adducts of polycyanoethylene and anthracene derivatives and their connection to the reversibility of Diels-Alder reactions
Publikation
Hirsch A,
Reutenauer P,
Le Moignan M,
Ulrich S,
Boul P,
Harrowfield J,
Jarowski P,
Lehn J
(2014)
Chemistry (Weinheim an der Bergstrasse, Germany), 20, 4, 1073-80, 10.1002/chem.201303276, 24339005
Chemistry (Weinheim an der Bergstrasse, Germany), 20, 4, 1073-80, 10.1002/chem.201303276, 24339005
PHIP-label: parahydrogen-induced polarization in propargylglycine-containing synthetic oligopeptides
Publikation
Körner M,
Sauer G,
Heil A,
Nasu D,
Empting M,
Tietze D,
Voigt S,
Weidler H,
Gutmann T,
Avrutina O,
Kolmar H,
Ratajczyk T,
Buntkowsky G
(2013)
Chemical communications (Cambridge, England), 49, 71, 7839-41, 10.1039/c3cc43978j, 23887355
Chemical communications (Cambridge, England), 49, 71, 7839-41, 10.1039/c3cc43978j, 23887355
Total synthesis, stereochemical elucidation and biological evaluation of Ac 2 SGL; a 1,3-methyl branched sulfoglycolipid from Mycobacterium tuberculosis
Publikation
Geerdink D,
Horst B,
Lepore M,
Mori L,
Puzo G,
Hirsch A,
Gilleron M,
Libero G,
Minnaard A
(2013)
, 10.1039/C2SC21620E
, 10.1039/C2SC21620E
Imidazole- and Benzimidazole-Based Inhibitors of the Kinase IspE: Targeting the Substrate-Binding Site and the Triphosphate-Binding Loop of the ATP Site
Publikation
Mombelli P,
Le Chapelain C,
Munzinger N,
Joliat E,
Illarionov B,
Schweizer W,
Hirsch A,
Fischer M,
Bacher A,
Diederich F
(2013)
, 10.1002/EJOC.201201467
, 10.1002/EJOC.201201467
The isoprenoid-precursor dependence of Plasmodium spp
Publikation
van der Meer J,
Hirsch A
(2012)
Natural product reports, 29, 7, 721-8, 10.1039/c2np20013a, 22555616
Natural product reports, 29, 7, 721-8, 10.1039/c2np20013a, 22555616
Metal-ion-induced shape switching: Stereoselective formation of a dinuclear Hg(II) double helicate from a hydrazonobis(acylhydrazone) ligand
Publikation
Schaeffer G,
Harrowfield J,
Lehn J,
Hirsch A
(2012)
, 10.1016/J.POLY.2012.04.013
, 10.1016/J.POLY.2012.04.013
Exploring the Ribose Sub-Pocket of the Substrate-Binding Site in Escherichia coli IspE: Structure-Based Design, Synthesis, and Biological Evaluation of Cytosines and Cytosine Analogues
Publikation
Schütz A,
Osawa S,
Mathis J,
Hirsch A,
Bernet B,
Illarionov B,
Fischer M,
Bacher A,
Diederich F
(2012)
, 10.1002/EJOC.201200296
, 10.1002/EJOC.201200296