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Imidazole- and Benzimidazole-Based Inhibitors of the Kinase IspE: Targeting the Substrate-Binding Site and the Triphosphate-Binding Loop of the ATP Site
Publikation
Mombelli P,
Le Chapelain C,
Munzinger N,
Joliat E,
Illarionov B,
Schweizer W,
Hirsch A,
Fischer M,
Bacher A,
Diederich F
(2013)
, 10.1002/EJOC.201201467
, 10.1002/EJOC.201201467
The isoprenoid-precursor dependence of Plasmodium spp
Publikation
van der Meer J,
Hirsch A
(2012)
Natural product reports, 29, 7, 721-8, 10.1039/c2np20013a, 22555616
Natural product reports, 29, 7, 721-8, 10.1039/c2np20013a, 22555616
Metal-ion-induced shape switching: Stereoselective formation of a dinuclear Hg(II) double helicate from a hydrazonobis(acylhydrazone) ligand
Publikation
Schaeffer G,
Harrowfield J,
Lehn J,
Hirsch A
(2012)
, 10.1016/J.POLY.2012.04.013
, 10.1016/J.POLY.2012.04.013
Exploring the Ribose Sub-Pocket of the Substrate-Binding Site in Escherichia coli IspE: Structure-Based Design, Synthesis, and Biological Evaluation of Cytosines and Cytosine Analogues
Publikation
Schütz A,
Osawa S,
Mathis J,
Hirsch A,
Bernet B,
Illarionov B,
Fischer M,
Bacher A,
Diederich F
(2012)
, 10.1002/EJOC.201200296
, 10.1002/EJOC.201200296
From pico to nano: biofunctionalization of cube-octameric silsesquioxanes by peptides and miniproteins
Publikation
Fabritz S,
Hörner S,
Könning D,
Empting M,
Reinwarth M,
Dietz C,
Glotzbach B,
Frauendorf H,
Kolmar H,
Avrutina O
(2012)
Org. Biomol. Chem., 10, 31, 6287-93, 10.1039/c2ob25728a, 22733169
Org. Biomol. Chem., 10, 31, 6287-93, 10.1039/c2ob25728a, 22733169
Between two worlds: a comparative study on in vitro and in silico inhibition of trypsin and matriptase by redox-stable SFTI-1 variants at near physiological pH
Publikation
Avrutina O,
Fittler H,
Glotzbach B,
Kolmar H,
Empting M
(2012)
Org. Biomol. Chem., 10, 38, 7753-62, 10.1039/c2ob26162f, 22903577
Org. Biomol. Chem., 10, 38, 7753-62, 10.1039/c2ob26162f, 22903577
Biodynamers: self-organization-driven formation of doubly dynamic proteoids
Publikation
Hirsch A,
Buhler E,
Lehn J
(2012)
Journal of the American Chemical Society, 134, 9, 4177-83, 10.1021/ja2099134, 22300496
Journal of the American Chemical Society, 134, 9, 4177-83, 10.1021/ja2099134, 22300496
Braces for the peptide backbone: insights into structure-activity relationships of protease inhibitor mimics with locked amide conformations
Publikation
Tischler M,
Nasu D,
Empting M,
Schmelz S,
Heinz D,
Rottmann P,
Kolmar H,
Buntkowsky G,
Tietze D,
Avrutina O
(2012)
Angewandte Chemie (International ed. in English), 51, 15, 3708-12, 10.1002/anie.201108983, 22374650
Angewandte Chemie (International ed. in English), 51, 15, 3708-12, 10.1002/anie.201108983, 22374650
Total synthesis of (-)-doliculide, structure-activity relationship studies and its binding to F-actin
Publikation
Matcha K,
Madduri A,
Roy S,
Ziegler S,
Waldmann H,
Hirsch A,
Minnaard A
(2012)
ChemBioChem, 13, 17, 2537-48, 10.1002/cbic.201200512, 23129522
ChemBioChem, 13, 17, 2537-48, 10.1002/cbic.201200512, 23129522
'Triazole bridge': disulfide-bond replacement by ruthenium-catalyzed formation of 1,5-disubstituted 1,2,3-triazoles
Publikation
Empting M,
Avrutina O,
Meusinger R,
Fabritz S,
Reinwarth M,
Biesalski M,
Voigt S,
Buntkowsky G,
Kolmar H
(2011)
Angewandte Chemie (International ed. in English), 50, 22, 5207-11, 10.1002/anie.201008142, 21544910
Angewandte Chemie (International ed. in English), 50, 22, 5207-11, 10.1002/anie.201008142, 21544910