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Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes
Publikation
Geißler A,
Junca H,
Kany A,
Daumann L,
Hirsch A,
Pieper D,
Sieber S
(2024)
Chem. Sci., 15, 30, 11946-11955, 10.1039/D4SC01940G, 39092115
Chem. Sci., 15, 30, 11946-11955, 10.1039/D4SC01940G, 39092115
Spray drying of a zinc complexing agent for inhalation therapy of pulmonary fibrosis
Publikation
Stella J,
Abdelaal M,
Kamal M,
Shehu K,
Alhayek A,
Haupenthal J,
Hirsch A,
Schneider M
(2024)
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 202, 10.1016/j.ejps.2024.106891, 39233259
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 202, 10.1016/j.ejps.2024.106891, 39233259
Targeting Plasmodium falciparum IspD in the Methyl-d-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity
Publikation
Willocx D,
Bizzarri L,
Alhayek A,
Kannan D,
Bravo P,
Illarionov B,
Rox K,
Lohse J,
Fischer M,
Kany A,
Hahne H,
Rottmann M,
Witschel M,
Odom John A,
Hamed M,
Diamanti E,
Hirsch A
(2024)
Journal of medicinal chemistry, 67, 19, 17070-17086, 10.1021/acs.jmedchem.4c00212, 39303294
Journal of medicinal chemistry, 67, 19, 17070-17086, 10.1021/acs.jmedchem.4c00212, 39303294
Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds
Publikation
Zender M,
Witzgall F,
Drees S,
Weidel E,
Maurer C,
Fetzner S,
Blankenfeldt W,
Empting M,
Hartmann R
(2016)
ACS chemical biology, 10.1021/acschembio.6b00156, 27082157
ACS chemical biology, 10.1021/acschembio.6b00156, 27082157
Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors
Publikation
Elgaher W,
Sharma K,
Haupenthal J,
Saladini F,
Pires M,
Real E,
Mely Y,
Hartmann R
(2016)
Journal of medicinal chemistry, 10.1021/acs.jmedchem.6b00730, 27339173
Journal of medicinal chemistry, 10.1021/acs.jmedchem.6b00730, 27339173
Structure-Activity Relationships of 2-Sufonylpyrimidines as Quorum-Sensing Inhibitors to Tackle Biofilm Formation and eDNA Release of Pseudomonas aeruginosa
Publikation
Thomann A,
Brengel C,
Börger C,
Kail D,
Steinbach A,
Empting M,
Hartmann R
(2016)
ChemMedChem, 11, 22, 2522-2533, 10.1002/cmdc.201600419, 27731921
ChemMedChem, 11, 22, 2522-2533, 10.1002/cmdc.201600419, 27731921
Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site
Publikation
Masini T,
Birkaya B,
van Dijk S,
Mondal M,
Hekelaar J,
Jäger M,
van Terwisscha Scheltinga A,
Patel M,
Hirsch A,
Moman E
(2016)
Journal of enzyme inhibition and medicinal chemistry, 31, sup4, 170-175, 10.1080/14756366.2016.1201812, 27435185
Journal of enzyme inhibition and medicinal chemistry, 31, sup4, 170-175, 10.1080/14756366.2016.1201812, 27435185
Synthesis and Anticonvulsant Activity of Menthyl γ-Aminobutyrate
Publikation
Nesterkina M,
Kravchenko I
(2016)
Chem Nat Compd, 52, 2, 237-239, 10.1007/s10600-016-1604-9
Chem Nat Compd, 52, 2, 237-239, 10.1007/s10600-016-1604-9
Synthesis and Pharmacological Properties of Novel Esters Based on Monocyclic Terpenes and GABA
Publikation
Nesterkina M,
Kravchenko I
(2016)
Pharmaceuticals (Basel, Switzerland), 9, 2, 10.3390/ph9020032, 27304960
Pharmaceuticals (Basel, Switzerland), 9, 2, 10.3390/ph9020032, 27304960
Analgesic Activity of Novel GABA Esters after Transdermal Delivery
Publikation
Nesterkina M,
Kravchenko I
(2016)
Nat. Prod. Commun., 11, 10, 10.1177/1934578X1601101001
Nat. Prod. Commun., 11, 10, 10.1177/1934578X1601101001