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Gesucht nach "drug". Zeige Ergebnisse 631 bis 640 von 705.

Dynamic combinatorial chemistry: a tool to facilitate the identification of inhibitors for protein targets

Publikation
Mondal M, Hirsch A (2015)
Chemical Society reviews, 44, 8, 2455-88, 10.1039/c4cs00493k, 25706945

De novo fragment-based design of inhibitors of DXS guided by spin-diffusion-based NMR spectroscopy

Publikation
Masini T, Pilger J, Kroezen B, Illarionov B, Lottmann P, Fischer M, Griesinger C, Hirsch A (2014)
Chem. Sci., 5, 9, 3543-3551, 10.1039/C4SC00588K

A doubly hermaphroditic chiral crown ether

Publikation
Hirsch A, Sirlin C, Harrowfield J, Lehn J (2014)
, 10.1039/C4CE00879K

Composing compound libraries for hit discovery--rationality-driven preselection or random choice by structural diversity?

Publikation
Weidel E, Negri M, Empting M, Hinsberger S, Hartmann R (2014)
Future medicinal chemistry, 6, 18, 2057-72, 10.4155/fmc.14.142, 25531968

Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections

Publikation
Hinsberger S, Jong J, Groh M, Haupenthal J, Hartmann R (2014)
European journal of medicinal chemistry, 76, 343-51, 10.1016/j.ejmech.2014.02.014, 24589489

Synthesis, Physicochemical Properties, and Anticonvulsant Activity of the Gaba Complex with a Calix[4]Arene derivative

Publikation
Nesterkina M, Alekseeva E, Kravchenko I (2014)
Pharm Chem J, 48, 2, 82-84, 10.1007/s11094-014-1052-4

Potent inhibitors of human matriptase-1 based on the scaffold of sunflower trypsin inhibitor

Publikation
Fittler H, Avrutina O, Empting M, Kolmar H (2014)
Journal of peptide science : an official publication of the European Peptide Society, 20, 6, 415-20, 10.1002/psc.2629, 24723440

Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents

Publikation
Masini T, Hirsch A (2014)
Journal of medicinal chemistry, 57, 23, 9740-63, 10.1021/jm5010978, 25210872

Overcoming the unexpected functional inversion of a PqsR antagonist in Pseudomonas aeruginosa: an in vivo potent antivirulence agent targeting pqs quorum sensing

Publikation
Lu C, Maurer C, Kirsch B, Steinbach A, Hartmann R (2014)
Angewandte Chemie (International ed. in English), 53, 4, 1109-12, 10.1002/anie.201307547, 24338917

Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry

Publikation
Mondal M, Radeva N, Köster H, Park A, Potamitis C, Zervou M, Klebe G, Hirsch A (2014)
Angewandte Chemie (International ed. in English), 53, 12, 3259-63, 10.1002/anie.201309682, 24532096