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Gesucht nach "drug". Zeige Ergebnisse 611 bis 620 von 672.

Targeting Plasmodium falciparum IspD in the Methyl-d-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity

Publikation
Willocx D, Bizzarri L, Alhayek A, Kannan D, Bravo P, Illarionov B, Rox K, Lohse J, Fischer M, Kany A, Hahne H, Rottmann M, Witschel M, Odom John A, Hamed M, Diamanti E, Hirsch A (2024)
Journal of medicinal chemistry, 67, 19, 17070-17086, 10.1021/acs.jmedchem.4c00212, 39303294

Integral Solvent-Induced Protein Precipitation for Target-Engagement Studies in Plasmodium falciparum

Publikation
Bravo P, Bizzarri L, Steinbrunn D, Lohse J, Hirsch A, Mäser P, Rottmann M, Hahne H (2024)
ACS Infect. Dis., 10, 12, 4073-4086, 10.1021/acsinfecdis.4c00418, 39631773

Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT

Publikation
Exapicheidou I, Shams A, Ibrahim H, Tsarenko A, Backenköhler M, Hamed M, Diamanti E, Volkamer A, slotboom d, Hirsch A (2024)
Chem. Commun., 60, 7, 870-873, 10.1039/D3CC04738E, 38164786

Identification of inhibitors targeting the energy-coupling factor (ECF) transporters

Publikation
Diamanti E, Souza P, Setyawati I, Bousis S, Monjas L, Swier L, Shams A, Tsarenko A, Stanek W, Jäger M, Marrink S, slotboom d, Hirsch A (2024)
Communications Biology, 7, 1, 10.1038/s42003-024-05770-0, 38195913

IspE kinase as an anti-infective target: Role of a hydrophobic pocket in inhibitor binding

Publikation
Hamid R, Walsh D, Diamanti E, Aguilar D, Lacour A, Hamed M, Hirsch A (2024)
Structure (London, England : 1993), 32, 12, 2390-2398, 10.1016/j.str.2024.10.009, 39510075

High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum

Publikation
Johannsen S, Gierse R, Krüger A, Edwards R, Nanna V, Fontana A, Di Zhu, Masini T, Carvalho L, Poizat M, Kieftenbelt B, Hodge D, Alvarez S, Bunt D, Lacour A, Shams A, Meissner K, Souza E, Dröge M, van Vliet B, Hartog J, Hutter M, Held J, Odom John A, Wrenger C, Hirsch* A (2024)
ACS Infect. Dis., 10.1021/acsinfecdis.3c00670, 38367280

Targeting the Plasmodium falciparum IspE Enzyme

Publikation
Diamanti E, Steinbach A, Carvalho L, Ropponen H, Lacour A, Hamid R, Eisa S, Bravo P, Bousis S, Illarionov B, Fischer M, Hamed M, Bach N, Rottmann M, Held J, Witschel M, Sieber S, Hirsch A (2024)
ACS omega, 9, 44, 44465-44473, 10.1021/acsomega.4c06038, 39524657

Behavioral and electrophysiological responses of the male medfly, Ceratitis capitata, to thymol and carvacrol ethers

Publikation
Tabanca N, Cloonan K, Nesterkina M, Gill M, Montgomery W, Kravchenko I, Kendra P (2024)
Pest management science, 10.1002/ps.8324, 39096116

Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes

Publikation
Chan A, Ho T, Fathoni I, Hamid R, Hirsch A, Saliba K, Leeper F (2024)
RSC Med. Chem., 15, 5, 1773-1781, 10.1039/D4MD00083H, 38784473

Studying Target-Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry

Publikation
Bizzarri L, Steinbrunn D, Quennesson T, Lacour A, Bianchino G, Bravo P, Chaignon P, Lohse J, Mäser P, Seemann M, van Calenbergh S, Hirsch A, Hahne H (2024)
ACS Infect. Dis., 10, 12, 4087-4102, 10.1021/acsinfecdis.4c00417, 39566904