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Design and Optimization of Simplified Inhibitors Targeting E. coli and K. pneumoniae IspE
Publikation
Walsh D,
Hamid R,
Giele T,
Rottmann M,
Hirsch A,
Hamed M,
Reiling N
(2026)
RSC Med. Chem., 17, 3, 10.1039/D5MD00874C
RSC Med. Chem., 17, 3, 10.1039/D5MD00874C
From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds
Publikation
Keddis P,
My Tu T,
Scherer H,
Kany A,
Hafez D,
Darwish S,
Abadi A,
Hirsch A,
Engel M,
Hamed M,
Horng J,
Abdel-Halim M
(2025)
Eur. J. Med. Chem., 287, 10.1016/j.ejmech.2025.117348, 39947051
Eur. J. Med. Chem., 287, 10.1016/j.ejmech.2025.117348, 39947051
Apo structure of Mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate synthase DXPS: Dynamics and implications for inhibitor design
Publikation
Gawriljuk V,
Alhayek A,
Hirsch A,
Groves M
(2025)
Biochemical and Biophysical Research Communications, 747, 10.1016/j.bbrc.2024.151246
Biochemical and Biophysical Research Communications, 747, 10.1016/j.bbrc.2024.151246
Targeting IspD for Anti-infective and Herbicide Development: Exploring Its Role, Mechanism, and Structural Insights
Publikation
Willocx D,
Diamanti E,
Hirsch A
(2025)
Journal of medicinal chemistry, 10.1021/acs.jmedchem.4c01146, 39749898
Journal of medicinal chemistry, 10.1021/acs.jmedchem.4c01146, 39749898
Lignin-derived guaiacols as platform chemicals for the modular synthesis of 1,2,3,4-tetrahydroquinolines and benzomorpholines
Publikation
Castillo-Garcia A,
Haupenthal J,
Hirsch A,
Barta K
(2025)
RSC sustainability, 3, 9, 4039-4048, 10.1039/d5su00151j, 40686926
RSC sustainability, 3, 9, 4039-4048, 10.1039/d5su00151j, 40686926
Role of Electrostatics in Metal–Organic Junctions on Surfaces: para -Hexaphenyl-dicarbonitrile on Au(111)
Publikation
Pérez Paz A,
Mowbray D,
Gottardi S,
Solianyk L,
Li J,
Monjas L,
Hirsch A,
Stöhr M,
Moreno-López J
(2025)
Chem. Mater., 37, 18, 7115-7124, 10.1021/acs.chemmater.5c01172
Chem. Mater., 37, 18, 7115-7124, 10.1021/acs.chemmater.5c01172
Targeting isoprenoid-precursor biosynthesis in Klebsiella pneumoniae: Design, synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) inhibitors
Publikation
Eisa S,
Lacour A,
Johannsen S,
Hamid R,
Raj P,
Heinz D,
Hamed M,
Diamanti E,
Hirsch A
(2025)
Bioorg. Chem., 164, 10.1016/j.bioorg.2025.108877, 40845551
Bioorg. Chem., 164, 10.1016/j.bioorg.2025.108877, 40845551
Design, Synthesis, and Biological Evaluation of Mono- and Diamino-Substituted Squaramide Derivatives as Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthase
Publikation
Palme P,
Grover S,
Abdelaziz R,
Mann L,
Kany A,
Ouologuem L,
Bartel K,
Sonnenkalb L,
Reiling N,
Hirsch A,
Schnappinger D,
Rubinstein J,
Imming P,
Richter A
(2025)
J. Med. Chem., 68, 23, 25274-25289, 10.1021/acs.jmedchem.5c02284, 41277442
J. Med. Chem., 68, 23, 25274-25289, 10.1021/acs.jmedchem.5c02284, 41277442
The influence of monoterpenoids and phenol derivatives on Drosophila melanogaster viability
Publikation
Nesterkina M,
Bilokon S,
Alieksieieva T,
Chubyk I,
Kravchenko I
(2018)
Journal of Asia-Pacific Entomology, 21, 3, 793-796, 10.1016/j.aspen.2018.06.004
Journal of Asia-Pacific Entomology, 21, 3, 793-796, 10.1016/j.aspen.2018.06.004
Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers
Publikation
Schütz C,
Empting M
(2018)
Beilstein journal of organic chemistry, 14, 2627-2645, 10.3762/bjoc.14.241, 30410625
Beilstein journal of organic chemistry, 14, 2627-2645, 10.3762/bjoc.14.241, 30410625