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From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds
Publikation
Keddis P,
My Tu T,
Scherer H,
Kany A,
Hafez D,
Darwish S,
Abadi A,
Hirsch A,
Engel M,
Hamed M,
Horng J,
Abdel-Halim M
(2025)
Eur. J. Med. Chem., 287, 10.1016/j.ejmech.2025.117348, 39947051
Eur. J. Med. Chem., 287, 10.1016/j.ejmech.2025.117348, 39947051
Apo structure of Mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate synthase DXPS: Dynamics and implications for inhibitor design
Publikation
Gawriljuk V,
Alhayek A,
Hirsch A,
Groves M
(2025)
Biochemical and Biophysical Research Communications, 747, 10.1016/j.bbrc.2024.151246
Biochemical and Biophysical Research Communications, 747, 10.1016/j.bbrc.2024.151246
Direct monitoring of intracellular polymer degradation via BODIPY dynamic dequenching
Publikation
Bassil J,
Kamal M,
Gabelmann A,
Christoulaki A,
Koch M,
Hamed M,
Loretz B,
Gallei M,
Buhler E,
Lehr C,
Hirsch A,
Lee S
(2025)
Mater. Des., 256, 10.1016/j.matdes.2025.114240
Mater. Des., 256, 10.1016/j.matdes.2025.114240
Targeting IspD for Anti-infective and Herbicide Development: Exploring Its Role, Mechanism, and Structural Insights
Publikation
Willocx D,
Diamanti E,
Hirsch A
(2025)
Journal of medicinal chemistry, 10.1021/acs.jmedchem.4c01146, 39749898
Journal of medicinal chemistry, 10.1021/acs.jmedchem.4c01146, 39749898
Lignin-derived guaiacols as platform chemicals for the modular synthesis of 1,2,3,4-tetrahydroquinolines and benzomorpholines
Publikation
Castillo-Garcia A,
Haupenthal J,
Hirsch A,
Barta K
(2025)
RSC sustainability, 3, 9, 4039-4048, 10.1039/d5su00151j, 40686926
RSC sustainability, 3, 9, 4039-4048, 10.1039/d5su00151j, 40686926
Role of Electrostatics in Metal–Organic Junctions on Surfaces: para -Hexaphenyl-dicarbonitrile on Au(111)
Publikation
Pérez Paz A,
Mowbray D,
Gottardi S,
Solianyk L,
Li J,
Monjas L,
Hirsch A,
Stöhr M,
Moreno-López J
(2025)
Chem. Mater., 37, 18, 7115-7124, 10.1021/acs.chemmater.5c01172
Chem. Mater., 37, 18, 7115-7124, 10.1021/acs.chemmater.5c01172
Targeting isoprenoid-precursor biosynthesis in Klebsiella pneumoniae: Design, synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) inhibitors
Publikation
Eisa S,
Lacour A,
Johannsen S,
Hamid R,
Raj P,
Heinz D,
Hamed M,
Diamanti E,
Hirsch A
(2025)
Bioorg. Chem., 164, 10.1016/j.bioorg.2025.108877, 40845551
Bioorg. Chem., 164, 10.1016/j.bioorg.2025.108877, 40845551
1-Deoxy-D-xylulose 5-phosphate synthase: structural perspectives on an essential enzyme in isoprenoid biosynthesis
Publikation
Gawriljuk V,
Oerlemans R,
Reddem E,
Gierse R,
Hirsch A,
Groves M
(2025)
J. Struct. Biol., 217, 3, 10.1016/j.jsb.2025.108236, 40784416
J. Struct. Biol., 217, 3, 10.1016/j.jsb.2025.108236, 40784416
Tobramycin crosslinking improves the colloidal stability of arginine chitosan biodynamers for safe and efficient siRNA delivery
Publikation
Liu Y,
Biesel A,
Kamal M,
Latta L,
Loretz B,
Hirsch A,
Lee S,
Lehr C
(2025)
Int. J. Biol. Macromol., 311, Pt 1, 10.1016/j.ijbiomac.2025.143420, 40274164
Int. J. Biol. Macromol., 311, Pt 1, 10.1016/j.ijbiomac.2025.143420, 40274164
Domain adaptable language modeling of chemical compounds identifies potent pathoblockers for Pseudomonas aeruginosa
Publikation
Kallergis G,
Asgari E,
Empting M,
Hirsch A,
Klawonn F,
McHardy A
(2025)
Commun. Chem., 8, 1, 10.1038/s42004-025-01484-4, 40216964
Commun. Chem., 8, 1, 10.1038/s42004-025-01484-4, 40216964