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Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD
Publikation
Willocx D,
D'Auria L,
Walsh D,
Scherer H,
Alhayek A,
Hamed M,
Borel F,
Diamanti E,
Hirsch A
(2024)
Angew. Chem., Int. Ed. Engl., 10.1002/anie.202414615, 39676054
Angew. Chem., Int. Ed. Engl., 10.1002/anie.202414615, 39676054
Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE
Publikation
Braun-Cornejo M,
Ornago C,
Sonawane V,
Haupenthal J,
Kany A,
Diamanti E,
Jézéquel G,
Reiling N,
Blankenfeldt W,
Maas P,
Hirsch A
(2024)
ACS omega, 10.1021/acsomega.4c05537
ACS omega, 10.1021/acsomega.4c05537
AI is a viable alternative to high throughput screening: a 318-target study
Publikation
Wallach I,
Hirsch,
Anna K. H. et al.
(2024)
Sci. Rep., 14, 1, 10.1038/s41598-024-54655-z, 38565852
Sci. Rep., 14, 1, 10.1038/s41598-024-54655-z, 38565852
Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes
Publikation
Geißler A,
Junca H,
Kany A,
Daumann L,
Hirsch A,
Pieper D,
Sieber S
(2024)
Chem. Sci., 15, 30, 11946-11955, 10.1039/D4SC01940G, 39092115
Chem. Sci., 15, 30, 11946-11955, 10.1039/D4SC01940G, 39092115
Spray drying of a zinc complexing agent for inhalation therapy of pulmonary fibrosis
Publikation
Stella J,
Abdelaal M,
Kamal M,
Shehu K,
Alhayek A,
Haupenthal J,
Hirsch A,
Schneider M
(2024)
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 202, 10.1016/j.ejps.2024.106891, 39233259
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 202, 10.1016/j.ejps.2024.106891, 39233259
Targeting Plasmodium falciparum IspD in the Methyl-d-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity
Publikation
Willocx D,
Bizzarri L,
Alhayek A,
Kannan D,
Bravo P,
Illarionov B,
Rox K,
Lohse J,
Fischer M,
Kany A,
Hahne H,
Rottmann M,
Witschel M,
Odom John A,
Hamed M,
Diamanti E,
Hirsch A
(2024)
Journal of medicinal chemistry, 67, 19, 17070-17086, 10.1021/acs.jmedchem.4c00212, 39303294
Journal of medicinal chemistry, 67, 19, 17070-17086, 10.1021/acs.jmedchem.4c00212, 39303294
Integral Solvent-Induced Protein Precipitation for Target-Engagement Studies in Plasmodium falciparum
Publikation
Bravo P,
Bizzarri L,
Steinbrunn D,
Lohse J,
Hirsch A,
Mäser P,
Rottmann M,
Hahne H
(2024)
ACS Infect. Dis., 10, 12, 4073-4086, 10.1021/acsinfecdis.4c00418, 39631773
ACS Infect. Dis., 10, 12, 4073-4086, 10.1021/acsinfecdis.4c00418, 39631773
Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT
Publikation
Exapicheidou I,
Shams A,
Ibrahim H,
Tsarenko A,
Backenköhler M,
Hamed M,
Diamanti E,
Volkamer A,
slotboom d,
Hirsch A
(2024)
Chem. Commun., 60, 7, 870-873, 10.1039/D3CC04738E, 38164786
Chem. Commun., 60, 7, 870-873, 10.1039/D3CC04738E, 38164786
Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor
Publikation
Drost M,
Diamanti E,
Fuhrmann K,
Goes A,
Shams A,
Haupenthal J,
Koch M,
Hirsch A,
Fuhrmann G
(2022)
Pharmaceutics, 14, 1, 10.3390/pharmaceutics14010004
Pharmaceutics, 14, 1, 10.3390/pharmaceutics14010004
Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors
Publikation
Wimmer S,
Hoff K,
Martin B,
Grewer M,
Denni L,
Lascorz Massanet R,
Raimondi M,
Bülbül E,
Melesina J,
Hotop S,
Haupenthal J,
Rohde H,
Heisig P,
Hirsch A,
Brönstrup M,
Sippl W,
Holl R
(2022)
Bioorganic chemistry, 131, 10.1016/j.bioorg.2022.106331, 36587505
Bioorganic chemistry, 131, 10.1016/j.bioorg.2022.106331, 36587505