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Design, synthesis and pharmacological profile of (−)-verbenone hydrazones
Publikation
Nesterkina M,
Barbalat D,
Kravchenko I
(2020)
Open Chemistry, 18, 1, 943-950, 10.1515/chem-2020-0103
Open Chemistry, 18, 1, 943-950, 10.1515/chem-2020-0103
1-Deoxy-D-xylulose 5-phosphate synthase: structural perspectives on an essential enzyme in isoprenoid biosynthesis
Publikation
Gawriljuk V,
Oerlemans R,
Reddem E,
Gierse R,
Hirsch A,
Groves M
(2025)
J. Struct. Biol., 217, 3, 10.1016/j.jsb.2025.108236, 40784416
J. Struct. Biol., 217, 3, 10.1016/j.jsb.2025.108236, 40784416
Tobramycin crosslinking improves the colloidal stability of arginine chitosan biodynamers for safe and efficient siRNA delivery
Publikation
Liu Y,
Biesel A,
Kamal M,
Latta L,
Loretz B,
Hirsch A,
Lee S,
Lehr C
(2025)
Int. J. Biol. Macromol., 311, Pt 1, 10.1016/j.ijbiomac.2025.143420, 40274164
Int. J. Biol. Macromol., 311, Pt 1, 10.1016/j.ijbiomac.2025.143420, 40274164
Domain adaptable language modeling of chemical compounds identifies potent pathoblockers for Pseudomonas aeruginosa
Publikation
Kallergis G,
Asgari E,
Empting M,
Hirsch A,
Klawonn F,
McHardy A
(2025)
Commun. Chem., 8, 1, 10.1038/s42004-025-01484-4, 40216964
Commun. Chem., 8, 1, 10.1038/s42004-025-01484-4, 40216964
Modular synthetic routes to biologically active indoles from lignin
Publikation
Castillo-Garcia A,
Haupenthal J,
Hirsch A,
Barta K
(2025)
Green Chem., 27, 25, 7506-7512, 10.1039/d5gc01003a, 40510740
Green Chem., 27, 25, 7506-7512, 10.1039/d5gc01003a, 40510740
Positive Charge in an Antimalarial Compound Unlocks Broad-Spectrum Antibacterial Activity
Publikation
Braun-Cornejo M,
Platteschorre M,
Vries V,
Bravo P,
Sonawane V,
Hamed M,
Haupenthal J,
Reiling N,
Rottmann M,
Piet D,
Maas P,
Diamanti E,
Hirsch A
(2025)
JACS Au, 5, 3, 1146-1156, 10.1021/jacsau.4c00935, 40151263
JACS Au, 5, 3, 1146-1156, 10.1021/jacsau.4c00935, 40151263
A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum
Publikation
Bravo P,
Diamanti E,
Hamed M,
Bizzarri L,
Wiedemar N,
Passecker A,
Brancucci N,
Albisetti A,
Gumpp C,
Illarionov B,
Fischer M,
Witschel M,
Schehl T,
Hahne H,
Mäser P,
Rottmann M,
Hirsch A
(2025)
Angew. Chem. Int. Ed., 64, 10.1002/anie.202514085, 41116297
Angew. Chem. Int. Ed., 64, 10.1002/anie.202514085, 41116297
Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity
Publikation
Mielniczuk S,
Hoff K,
Baselious F,
Li Y,
Haupenthal J,
Kany A,
Riedner M,
Rohde H,
Rox K,
Hirsch A,
Krimm I,
Sippl W,
Holl R
(2024)
Journal of medicinal chemistry, 67, 19, 17363-17391, 10.1021/acs.jmedchem.4c01262, 39303295
Journal of medicinal chemistry, 67, 19, 17363-17391, 10.1021/acs.jmedchem.4c01262, 39303295
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity
Publikation
Al-Saad O,
Gabr M,
Darwish S,
Rullo M,
Pisani L,
Miniero D,
Liuzzi G,
Kany A,
Hirsch A,
Abadi A,
Engel M,
Catto M,
Abdel-Halim M
(2024)
European journal of medicinal chemistry, 10.1016/j.ejmech.2024.116266
European journal of medicinal chemistry, 10.1016/j.ejmech.2024.116266
Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes
Publikation
Chen X,
Zhao H,
Wang C,
Hamed M,
Shang Q,
Yang Y,
Diao X,
Sun X,
Hu W,
Jiang X,
Zhang Y,
Hirsch A,
Wu D,
Zhuang J
(2024)
Int. J. Antimicrob. Agents, 63, 5, 10.1016/j.ijantimicag.2024.107160, 38537721
Int. J. Antimicrob. Agents, 63, 5, 10.1016/j.ijantimicag.2024.107160, 38537721