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Studying Target-Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry
Publikation
Bizzarri L,
Steinbrunn D,
Quennesson T,
Lacour A,
Bianchino G,
Bravo P,
Chaignon P,
Lohse J,
Mäser P,
Seemann M,
van Calenbergh S,
Hirsch A,
Hahne H
(2024)
ACS Infect. Dis., 10, 12, 4087-4102, 10.1021/acsinfecdis.4c00417, 39566904
ACS Infect. Dis., 10, 12, 4087-4102, 10.1021/acsinfecdis.4c00417, 39566904
Synthesis and Structure of a Coordination Polymer of Ni(II) with 2-(4-Bromophenoxy)acetohydrazide
Publikation
Martsynko ?,
Nesterkina M,
Finik ?,
Tsymbaliuk K,
Dyakonenko V,
Shishkina S,
Kravchenko I
(2024)
Molbank, 2024, 2, 10.3390/M1819
Molbank, 2024, 2, 10.3390/M1819
Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy-coupling factor transporters (ECFTs)
Publikation
Haupenthal J,
Rafehi M,
Kany A,
Lespine A,
Stefan K,
Hirsch* A,
Stefan* S
(2024)
Arch. Pharm., 10.1002/ardp.202400267, 38896404
Arch. Pharm., 10.1002/ardp.202400267, 38896404
Not Every Hit-Identification Technique Works on 1-Deoxy-d-Xylulose 5-Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign
Publikation
Johannsen S,
Gierse R,
Olshanova A,
Smerznak E,
Laggner C,
Eschweiler L,
Adeli Z,
Hamid R,
Alhayek A,
Reiling N,
Haupenthal J,
Hirsch A
(2023)
ChemMedChem, 10.1002/cmdc.202200590, 36896721
ChemMedChem, 10.1002/cmdc.202200590, 36896721
Identification of DksA as a novel pro-inflammatory mediator of Pseudomonas aeruginosa under conditions mimicking chronic cystic fibrosis lung infection
Publikation
Wauters M,
Bollé L,
Meester G,
van den Bossche S,
Grassi L,
van Haver D,
Dufour S,
Devos S,
Impens F,
van Braeckel E,
Hirsch A,
Whiteley M,
Saelens X,
Crabbé A
(2026)
Virulence, 17, 1, 10.1080/21505594.2026.2670050, 42117785
Virulence, 17, 1, 10.1080/21505594.2026.2670050, 42117785
Current methods and applications in the study of 1-Deoxy-D-xylulose 5-phosphate synthase (DXPS)
Publikation
Gawriljuk V,
Chen S,
Kramer L,
Smith N,
Diamanti E,
Hirsch A,
Freel Meyers C,
Groves M
(2026)
Methods in enzymology, 736, 61-94, 10.1016/bs.mie.2026.08.001, 42805709
Methods in enzymology, 736, 61-94, 10.1016/bs.mie.2026.08.001, 42805709
Hit-to-Lead Optimization of Energy-Coupling Factor (ECF) Transporter Inhibitors as Novel Antibiotic
Publikation
Exapicheidou I,
Tsarenko A,
Zeller L,
Ibrahim H,
Baumann C,
Shams A,
Hoffmann P,
Li Y,
Kany A,
Hermann J,
Slotboom D,
Müller R,
Volkamer A,
Hamed M,
Diamanti E,
Hirsch A
(2026)
Journal of medicinal chemistry, 69, 12, 14069-14084, 10.1021/acs.jmedchem.5c02721, 42249838
Journal of medicinal chemistry, 69, 12, 14069-14084, 10.1021/acs.jmedchem.5c02721, 42249838
An investigation of phosphinamides as a functional group for medicinal chemistry
Publikation
Meurillon V,
Blanchart P,
Ullah V,
Chan D,
Perry M
(2026)
Med Chem Res, 35, 1, 118-134, 10.1007/s00044-025-03498-y
Med Chem Res, 35, 1, 118-134, 10.1007/s00044-025-03498-y
Cytochrome P450-Mediated Metabolism of Antimycobacterial Nα-Aroyl-N-aryl-phenylalanine Amides
Publikation
Doering J,
Meerz E,
Seidel R,
Lang M,
Kany A,
Auriola S,
Juvonen R,
Raunio H,
Goddard R,
Zimmerman M,
Dartois V,
Hirsch A,
Dick T,
Richter A
(2026)
ACS Infect. Dis., 12, 6, 10.1021/acsinfecdis.6c00100, 42227659
ACS Infect. Dis., 12, 6, 10.1021/acsinfecdis.6c00100, 42227659
Identification of Natural-Product Inhibitors of the 2 C -Methyl- d -erythritol 4-Phosphate Pathway
Publikation
Diamanti E,
Alhayek A,
Lacour A,
Shahrour M,
Willocx D,
Illarionov B,
Fischer M,
Stadler M,
Reiling N,
Herrmann J,
Müller R,
Hirsch A
(2026)
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.6c00054
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.6c00054