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Double conjugate addition of dithiols to propargylic carbonyl systems to generate protected 1,3-dicarbonyl compounds
Publikation
Sneddon H,
van den Heuvel A,
Hirsch A,
Booth R,
Shaw D,
Gaunt M,
Ley S
(2006)
The Journal of organic chemistry, 71, 7, 2715-25, 10.1021/jo052514s, 16555825
The Journal of organic chemistry, 71, 7, 2715-25, 10.1021/jo052514s, 16555825
1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding
Publikation
Hamid R,
Adam S,
Lacour A,
Monjas L,
Köhnke J,
Hirsch A
(2023)
The Journal of biological chemistry, 10.1016/j.jbc.2023.105152, 37567475
The Journal of biological chemistry, 10.1016/j.jbc.2023.105152, 37567475
Identification of HuR–RNA Interfering Compounds by Dynamic Combinatorial Chemistry and Fluorescence Polarization
Publikation
Della Volpe S,
Listro R,
Ambrosio F,
Garbagnoli M,
Linciano P,
Rossi D,
Costa G,
Alcaro S,
Vasile F,
Hirsch A,
Collina S
(2023)
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.3c00303
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.3c00303
NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner
Publikation
Waqas F,
Shehata M,
Elgaher W,
Lacour A,
Kurmasheva N,
Begnini F,
Kiib A,
Dahlmann J,
Chen C,
Pavlou A,
Poulsen T,
Merkert S,
Martin U,
Olmer R,
Olagnier D,
Hirsch A,
Pleschka S,
Pessler F
(2023)
PLOS Pathogens, 19, 7, 10.1371/journal.ppat.1011506, 37459366
PLOS Pathogens, 19, 7, 10.1371/journal.ppat.1011506, 37459366
Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate
Publikation
Gawriljuk V,
Oerlemans R,
Gierse R,
Jotwani R,
Hirsch A,
Groves M
(2023)
Crystals, 13, 5, 10.3390/cryst13050737
Crystals, 13, 5, 10.3390/cryst13050737
The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB
Publikation
Camberlein V,
Jézéquel G,
Haupenthal J,
Hirsch A
(2022)
Antibiotics, 11, 8, 10.3390/antibiotics11081060
Antibiotics, 11, 8, 10.3390/antibiotics11081060
Design, Synthesis, Antimicrobial Activity, and Molecular Docking of Some New Diclofenac Derivatives
Publikation
Tolba M,
Hamed M,
Sayed M,
Kamal El-Dean A,
Abdel-Mohsen S,
Ibrahim O,
Elgaher W,
Hirsch A,
Saddik A
(2022)
Polycyclic Aromatic Compounds, 1-16, 10.1080/10406638.2022.2102661
Polycyclic Aromatic Compounds, 1-16, 10.1080/10406638.2022.2102661
N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases
Publikation
Kaya C,
Konstantinovic J,
Kany A,
Andreas A,
Kramer J,
Brunst S,
Weizel L,
Rotter M,
Frank D,
Yahiaoui S,
Müller R,
Hartmann R,
Haupenthal J,
Proschak E,
Wichelhaus T,
Hirsch A
(2022)
Journal of medicinal chemistry, 65, 5, 3913-3922, 10.1021/acs.jmedchem.1c01755, 35188771
Journal of medicinal chemistry, 65, 5, 3913-3922, 10.1021/acs.jmedchem.1c01755, 35188771
Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors
Publikation
Hamdy J,
Emadeldin N,
Hamed M,
Frakolaki E,
Katsamakas S,
Vassilaki N,
Zoidis G,
Hirsch A,
Abdel-Halim M,
Abadi A
(2022)
Pharmaceuticals, 15, 5, 10.3390/ph15050632, 35631457
Pharmaceuticals, 15, 5, 10.3390/ph15050632, 35631457
N-Aryl-2-iso-butylmercaptoacetamides: the discovery of highly potent and selective inhibitors of Pseudomonas aeruginosa virulence factor LasB and Clostridium histolyticum virulence factor ColH
Publikation
Voos K,
Yahiaoui S,
Konstantinovic J,
Schönauer E,
Alhayek A,
Sikandar A,
Si Chaib K,
Ramspoth T,
Rox K,
Haupenthal J,
Köhnke J,
Brandstetter H,
Ducho C,
Hirsch A
(2022)
ChemRxiv, 10.26434/chemrxiv-2022-fjrqr
ChemRxiv, 10.26434/chemrxiv-2022-fjrqr