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(1 R ,2 S ,5 R )-5-Methyl-2-(propan-2-yl)cyclohexyl 4-amino-3-phenylbutanoate hydrochloride: Synthesis and anticonvulsant activity
Publikation
Nesterkina M,
Musatov V,
Honcharova O,
Kravchenko I
(2022)
Open Chemistry, 20, 1, 703-707, 10.1515/chem-2022-0189
Open Chemistry, 20, 1, 703-707, 10.1515/chem-2022-0189
An Efficient Way to Screen Inhibitors of Energy-Coupling Factor (ECF) Transporters in a Bacterial Uptake Assay
Publikation
Bousis S,
Winkler S,
Haupenthal J,
Fulco F,
Diamanti E,
Hirsch A
(2022)
International journal of molecular sciences, 23, 5, 10.3390/ijms23052637, 35269783
International journal of molecular sciences, 23, 5, 10.3390/ijms23052637, 35269783
First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization
Publikation
Gierse R,
Oerlemans R,
Reddem E,
Gawriljuk V,
Alhayek A,
Baitinger D,
Jakobi H,
Laber B,
Lange G,
Hirsch A,
Groves M
(2022)
Sci. Rep., 12, 1, 10.1038/s41598-022-11205-9, 35508530
Sci. Rep., 12, 1, 10.1038/s41598-022-11205-9, 35508530
Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis
Publikation
Camberlein V,
Fléau C,
Sierocki P,
Li L,
Gealageas R,
Bosc D,
Guillaume V,
Warenghem S,
Leroux F,
Rosell M,
Cheng K,
Medve L,
Prigent M,
Decanter M,
Piveteau C,
Biela A,
Eveque M,
Dumont J,
Mpakali A,
Giastas P,
Herledan A,
Couturier C,
Haupenthal J,
Lesire L,
Hirsch A,
Deprez B,
Stratikos E,
Bouvier M,
Deprez-Poulain R
(2022)
Angew. Chemie, 134, 39, 10.1002/ange.202203560
Angew. Chemie, 134, 39, 10.1002/ange.202203560
Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa
Publikation
Kaya C,
Walter I,
Alhayek A,
Shafiei R,
Jézéquel G,
Andreas A,
Konstantinovic J,
Schönauer E,
Sikandar A,
Haupenthal J,
Müller R,
Brandstetter H,
Hartmann R,
Hirsch A
(2022)
ACS Infect. Dis., 10.1021/acsinfecdis.1c00628, 35451824
ACS Infect. Dis., 10.1021/acsinfecdis.1c00628, 35451824
PHARMACOLOGICAL AND PHYSICO-CHEMICAL PROPERTIES OF COMPOSITIONS BASED ON BIOSURFACTANTS AND N-CONTAINING HETEROCYCLIC DERIVATIVES OF 1,4-NAPHTHOQUINONE
Publikation
Polish N,
Nesterkina M,
Karkhut A,
Marintsova N,
Zhurakhivska L,
Volianiuk K,
Pokynbroda T,
Kravchenko I,
Karpenko E
(2022)
J microb biotech food sci, 12, 3, 10.55251/jmbfs.5956
J microb biotech food sci, 12, 3, 10.55251/jmbfs.5956
Multiparameter Optimization of Pseudomonas aeruginosa Elastase Inhibitors for Systemic Administration
Publikation
Abdelsamie A,
Konstantinovic J,
Kany A,
Schütz C,
Kolling D,
Speicher S,
Klein A,
Shafiei R,
Bouté M,
Mundry K,
Park Y,
Loretz B,
Müller R,
Sallenave J,
Lehr C,
Koehnke J,
Rox K,
Haupenthal J,
Hirsch A
(2026)
Journal of medicinal chemistry, 69, 4, 4160-4186, 10.1021/acs.jmedchem.5c02788, 41642952
Journal of medicinal chemistry, 69, 4, 4160-4186, 10.1021/acs.jmedchem.5c02788, 41642952
An investigation of phosphinamides as a functional group for medicinal chemistry
Publikation
Meurillon V,
Blanchart P,
Ullah V,
Chan D,
Perry M
(2026)
Med Chem Res, 35, 1, 118-134, 10.1007/s00044-025-03498-y
Med Chem Res, 35, 1, 118-134, 10.1007/s00044-025-03498-y
Identification of Natural-Product Inhibitors of the 2 C -Methyl- d -erythritol 4-Phosphate Pathway
Publikation
Diamanti E,
Alhayek A,
Lacour A,
Shahrour M,
Willocx D,
Illarionov B,
Fischer M,
Stadler M,
Reiling N,
Herrmann J,
Müller R,
Hirsch A
(2026)
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.6c00054
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.6c00054
Design and Optimization of Simplified Inhibitors Targeting E. coli and K. pneumoniae IspE
Publikation
Walsh D,
Hamid R,
Giele T,
Rottmann M,
Hirsch A,
Hamed M,
Reiling N
(2026)
RSC Med. Chem., 10.1039/D5MD00874C
RSC Med. Chem., 10.1039/D5MD00874C