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Energy-Coupling Factor Transporters as Novel Antimicrobial Targets
Publikation
Bousis S,
Setyawati I,
Diamanti E,
Slotboom D,
Hirsch A
(2019)
Advanced Therapeutics, 2, 1800066, 10.1002/ADTP.201800066
Advanced Therapeutics, 2, 1800066, 10.1002/ADTP.201800066
The Alkylquinolone Repertoire of Pseudomonas aeruginosa is Linked to Structural Flexibility of the FabH-like 2-Heptyl-3-hydroxy-4(1H)-quinolone (PQS) Biosynthesis Enzyme PqsBC
Publikation
Witzgall F,
Depke T,
Hoffmann M,
Empting M,
Brönstrup M,
Müller R,
Blankenfeldt W
(2018)
Chembiochem : a European journal of chemical biology, 19, 14, 1531-1544, 10.1002/cbic.201800153, 29722462
Chembiochem : a European journal of chemical biology, 19, 14, 1531-1544, 10.1002/cbic.201800153, 29722462
Exploration of ligand binding modes towards the identification of compounds targeting HuR: a combined STD-NMR and Molecular Modelling approach
Publikation
Vasile F,
Della Volpe S,
Ambrosio F,
Costa G,
Unver M,
Zucal C,
Rossi D,
Martino E,
Provenzani A,
Hirsch A,
Alcaro S,
Potenza D,
Collina S
(2018)
Sci. Rep., 8, 1, 10.1038/s41598-018-32084-z
Sci. Rep., 8, 1, 10.1038/s41598-018-32084-z
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity
Publikation
Al-Saad O,
Gabr M,
Darwish S,
Rullo M,
Pisani L,
Miniero D,
Liuzzi G,
Kany A,
Hirsch A,
Abadi A,
Engel M,
Catto M,
Abdel-Halim M
(2024)
European journal of medicinal chemistry, 10.1016/j.ejmech.2024.116266
European journal of medicinal chemistry, 10.1016/j.ejmech.2024.116266
Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes
Publikation
Chen X,
Zhao H,
Wang C,
Hamed M,
Shang Q,
Yang Y,
Diao X,
Sun X,
Hu W,
Jiang X,
Zhang Y,
Hirsch A,
Wu D,
Zhuang J
(2024)
Int. J. Antimicrob. Agents, 63, 5, 10.1016/j.ijantimicag.2024.107160, 38537721
Int. J. Antimicrob. Agents, 63, 5, 10.1016/j.ijantimicag.2024.107160, 38537721
Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain
Publikation
Gawriljuk V,
Godoy A,
Oerlemans R,
Welker L,
Hirsch A,
Groves M
(2024)
Nat. Commun., 15, 1, 10.1038/s41467-024-50671-9, 39103329
Nat. Commun., 15, 1, 10.1038/s41467-024-50671-9, 39103329
Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD
Publikation
Willocx D,
D'Auria L,
Walsh D,
Scherer H,
Alhayek A,
Hamed M,
Borel F,
Diamanti E,
Hirsch A
(2024)
Angew. Chem., Int. Ed. Engl., 10.1002/anie.202414615, 39676054
Angew. Chem., Int. Ed. Engl., 10.1002/anie.202414615, 39676054
Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE
Publikation
Braun-Cornejo M,
Ornago C,
Sonawane V,
Haupenthal J,
Kany A,
Diamanti E,
Jézéquel G,
Reiling N,
Blankenfeldt W,
Maas P,
Hirsch A
(2024)
ACS omega, 10.1021/acsomega.4c05537
ACS omega, 10.1021/acsomega.4c05537
AI is a viable alternative to high throughput screening: a 318-target study
Publikation
Wallach I,
Hirsch,
Anna K. H. et al.
(2024)
Sci. Rep., 14, 1, 10.1038/s41598-024-54655-z, 38565852
Sci. Rep., 14, 1, 10.1038/s41598-024-54655-z, 38565852
Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes
Publikation
Geißler A,
Junca H,
Kany A,
Daumann L,
Hirsch A,
Pieper D,
Sieber S
(2024)
Chem. Sci., 15, 30, 11946-11955, 10.1039/D4SC01940G, 39092115
Chem. Sci., 15, 30, 11946-11955, 10.1039/D4SC01940G, 39092115