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Gesucht nach "drug". Zeige Ergebnisse 561 bis 570 von 719.

Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain

Publikation
Gawriljuk V, Godoy A, Oerlemans R, Welker L, Hirsch A, Groves M (2024)
Nat. Commun., 15, 1, 10.1038/s41467-024-50671-9, 39103329

Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD

Publikation
Willocx D, D'Auria L, Walsh D, Scherer H, Alhayek A, Hamed M, Borel F, Diamanti E, Hirsch A (2024)
Angew. Chem., Int. Ed. Engl., 10.1002/anie.202414615, 39676054

Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE

Publikation
Braun-Cornejo M, Ornago C, Sonawane V, Haupenthal J, Kany A, Diamanti E, Jézéquel G, Reiling N, Blankenfeldt W, Maas P, Hirsch A (2024)
ACS omega, 10.1021/acsomega.4c05537

Identification of HuR–RNA Interfering Compounds by Dynamic Combinatorial Chemistry and Fluorescence Polarization

Publikation
Della Volpe S, Listro R, Ambrosio F, Garbagnoli M, Linciano P, Rossi D, Costa G, Alcaro S, Vasile F, Hirsch A, Collina S (2023)
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.3c00303

NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner

Publikation
Waqas F, Shehata M, Elgaher W, Lacour A, Kurmasheva N, Begnini F, Kiib A, Dahlmann J, Chen C, Pavlou A, Poulsen T, Merkert S, Martin U, Olmer R, Olagnier D, Hirsch A, Pleschka S, Pessler F (2023)
PLOS Pathogens, 19, 7, 10.1371/journal.ppat.1011506, 37459366

Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate

Publikation
Gawriljuk V, Oerlemans R, Gierse R, Jotwani R, Hirsch A, Groves M (2023)
Crystals, 13, 5, 10.3390/cryst13050737

The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB

Publikation
Camberlein V, Jézéquel G, Haupenthal J, Hirsch A (2022)
Antibiotics, 11, 8, 10.3390/antibiotics11081060

Design, Synthesis, Antimicrobial Activity, and Molecular Docking of Some New Diclofenac Derivatives

Publikation
Tolba M, Hamed M, Sayed M, Kamal El-Dean A, Abdel-Mohsen S, Ibrahim O, Elgaher W, Hirsch A, Saddik A (2022)
Polycyclic Aromatic Compounds, 1-16, 10.1080/10406638.2022.2102661

N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases

Publikation
Kaya C, Konstantinovic J, Kany A, Andreas A, Kramer J, Brunst S, Weizel L, Rotter M, Frank D, Yahiaoui S, Müller R, Hartmann R, Haupenthal J, Proschak E, Wichelhaus T, Hirsch A (2022)
Journal of medicinal chemistry, 65, 5, 3913-3922, 10.1021/acs.jmedchem.1c01755, 35188771

Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors

Publikation
Hamdy J, Emadeldin N, Hamed M, Frakolaki E, Katsamakas S, Vassilaki N, Zoidis G, Hirsch A, Abdel-Halim M, Abadi A (2022)
Pharmaceuticals, 15, 5, 10.3390/ph15050632, 35631457