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Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus-Based Wound Infection Model in SKH1 Mice
Publikation
Haupenthal J,
Kautz Y,
Elgaher W,
Pätzold L,
Röhrig T,
Laschke M,
Tschernig T,
Hirsch A,
Molodtsov V,
Murakami K,
Hartmann R,
Bischoff M
(2020)
ACS infectious diseases, 6, 10, 2573-2581, 10.1021/acsinfecdis.0c00034, 32886885
ACS infectious diseases, 6, 10, 2573-2581, 10.1021/acsinfecdis.0c00034, 32886885
1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding
Publikation
Hamid R,
Adam S,
Lacour A,
Monjas L,
Köhnke J,
Hirsch A
(2023)
The Journal of biological chemistry, 10.1016/j.jbc.2023.105152, 37567475
The Journal of biological chemistry, 10.1016/j.jbc.2023.105152, 37567475
Identification of HuR–RNA Interfering Compounds by Dynamic Combinatorial Chemistry and Fluorescence Polarization
Publikation
Della Volpe S,
Listro R,
Ambrosio F,
Garbagnoli M,
Linciano P,
Rossi D,
Costa G,
Alcaro S,
Vasile F,
Hirsch A,
Collina S
(2023)
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.3c00303
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.3c00303
NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner
Publikation
Waqas F,
Shehata M,
Elgaher W,
Lacour A,
Kurmasheva N,
Begnini F,
Kiib A,
Dahlmann J,
Chen C,
Pavlou A,
Poulsen T,
Merkert S,
Martin U,
Olmer R,
Olagnier D,
Hirsch A,
Pleschka S,
Pessler F
(2023)
PLOS Pathogens, 19, 7, 10.1371/journal.ppat.1011506, 37459366
PLOS Pathogens, 19, 7, 10.1371/journal.ppat.1011506, 37459366
Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate
Publikation
Gawriljuk V,
Oerlemans R,
Gierse R,
Jotwani R,
Hirsch A,
Groves M
(2023)
Crystals, 13, 5, 10.3390/cryst13050737
Crystals, 13, 5, 10.3390/cryst13050737
The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB
Publikation
Camberlein V,
Jézéquel G,
Haupenthal J,
Hirsch A
(2022)
Antibiotics, 11, 8, 10.3390/antibiotics11081060
Antibiotics, 11, 8, 10.3390/antibiotics11081060
Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes
Publikation
Chen X,
Zhao H,
Wang C,
Hamed M,
Shang Q,
Yang Y,
Diao X,
Sun X,
Hu W,
Jiang X,
Zhang Y,
Hirsch A,
Wu D,
Zhuang J
(2024)
Int. J. Antimicrob. Agents, 63, 5, 10.1016/j.ijantimicag.2024.107160, 38537721
Int. J. Antimicrob. Agents, 63, 5, 10.1016/j.ijantimicag.2024.107160, 38537721
Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain
Publikation
Gawriljuk V,
Godoy A,
Oerlemans R,
Welker L,
Hirsch A,
Groves M
(2024)
Nat. Commun., 15, 1, 10.1038/s41467-024-50671-9, 39103329
Nat. Commun., 15, 1, 10.1038/s41467-024-50671-9, 39103329
Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD
Publikation
Willocx D,
D'Auria L,
Walsh D,
Scherer H,
Alhayek A,
Hamed M,
Borel F,
Diamanti E,
Hirsch A
(2024)
Angew. Chem., Int. Ed. Engl., 10.1002/anie.202414615, 39676054
Angew. Chem., Int. Ed. Engl., 10.1002/anie.202414615, 39676054
Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE
Publikation
Braun-Cornejo M,
Ornago C,
Sonawane V,
Haupenthal J,
Kany A,
Diamanti E,
Jézéquel G,
Reiling N,
Blankenfeldt W,
Maas P,
Hirsch A
(2024)
ACS omega, 10.1021/acsomega.4c05537
ACS omega, 10.1021/acsomega.4c05537