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Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity
Publikation
Al-Saad O,
Gabr M,
Darwish S,
Rullo M,
Pisani L,
Miniero D,
Liuzzi G,
Kany A,
Hirsch A,
Abadi A,
Engel M,
Catto M,
Abdel-Halim M
(2024)
European journal of medicinal chemistry, 10.1016/j.ejmech.2024.116266
European journal of medicinal chemistry, 10.1016/j.ejmech.2024.116266
Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes
Publikation
Chen X,
Zhao H,
Wang C,
Hamed M,
Shang Q,
Yang Y,
Diao X,
Sun X,
Hu W,
Jiang X,
Zhang Y,
Hirsch A,
Wu D,
Zhuang J
(2024)
Int. J. Antimicrob. Agents, 63, 5, 10.1016/j.ijantimicag.2024.107160, 38537721
Int. J. Antimicrob. Agents, 63, 5, 10.1016/j.ijantimicag.2024.107160, 38537721
Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain
Publikation
Gawriljuk V,
Godoy A,
Oerlemans R,
Welker L,
Hirsch A,
Groves M
(2024)
Nat. Commun., 15, 1, 10.1038/s41467-024-50671-9, 39103329
Nat. Commun., 15, 1, 10.1038/s41467-024-50671-9, 39103329
Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD
Publikation
Willocx D,
D'Auria L,
Walsh D,
Scherer H,
Alhayek A,
Hamed M,
Borel F,
Diamanti E,
Hirsch A
(2024)
Angew. Chem., Int. Ed. Engl., 10.1002/anie.202414615, 39676054
Angew. Chem., Int. Ed. Engl., 10.1002/anie.202414615, 39676054
Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE
Publikation
Braun-Cornejo M,
Ornago C,
Sonawane V,
Haupenthal J,
Kany A,
Diamanti E,
Jézéquel G,
Reiling N,
Blankenfeldt W,
Maas P,
Hirsch A
(2024)
ACS omega, 10.1021/acsomega.4c05537
ACS omega, 10.1021/acsomega.4c05537
AI is a viable alternative to high throughput screening: a 318-target study
Publikation
Wallach I,
Hirsch,
Anna K. H. et al.
(2024)
Sci. Rep., 14, 1, 10.1038/s41598-024-54655-z, 38565852
Sci. Rep., 14, 1, 10.1038/s41598-024-54655-z, 38565852
Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster
Publikation
Nesterkina M,
Bilokon S,
Alieksieieva T,
Kravchenko I,
Hirsch A
(2023)
Toxicol. Rep., 10, 10.1016/j.toxrep.2023.02.009
Toxicol. Rep., 10, 10.1016/j.toxrep.2023.02.009
Selective Activation of TRPC6 Ion Channel by Metallated Type-B Polyprenylated Polycyclic Acylphloroglucinols
Publikation
Peslalz P,
Kraus F,
Izzo F,
Bleisch A,
El Hamdaoui Y,
Schulz I,
Kany A,
Hirsch A,
Friedland K,
Plietker B
(2023)
Manuscript, 10.26434/chemrxiv-2023-6w94r
Manuscript, 10.26434/chemrxiv-2023-6w94r
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle
Publikation
Hamed M,
Abdelsamie A,
Rox K,
Schütz C,
Kany A,
Röhrig T,
Schmelz S,
Blankenfeldt W,
Arce-Rodriguez A,
Borrero-de Acuña J,
Jahn D,
Rademacher J,
Ringshausen F,
Cramer N,
Tümmler B,
Hirsch A,
Hartmann R,
Empting M
(2023)
Adv. Sci., Online, 10.1002/advs.202204443
Adv. Sci., Online, 10.1002/advs.202204443
Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation
Publikation
Chan A,
Ho T,
Irfan R,
Hamid R,
Rudge E,
Iqbal A,
Turner A,
Hirsch A.,
Leeper F
(2023)
Bioorganic chemistry, 138, 10.1016/j.bioorg.2023.106602
Bioorganic chemistry, 138, 10.1016/j.bioorg.2023.106602