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Identification of inhibitors targeting the energy-coupling factor (ECF) transporters
Publikation
Diamanti E,
Souza P,
Setyawati I,
Bousis S,
Monjas L,
Swier L,
Shams A,
Tsarenko A,
Stanek W,
Jäger M,
Marrink S,
slotboom d,
Hirsch A
(2024)
Communications Biology, 7, 1, 10.1038/s42003-024-05770-0, 38195913
Communications Biology, 7, 1, 10.1038/s42003-024-05770-0, 38195913
IspE kinase as an anti-infective target: Role of a hydrophobic pocket in inhibitor binding
Publikation
Hamid R,
Walsh D,
Diamanti E,
Aguilar D,
Lacour A,
Hamed M,
Hirsch A
(2024)
Structure (London, England : 1993), 32, 12, 2390-2398, 10.1016/j.str.2024.10.009, 39510075
Structure (London, England : 1993), 32, 12, 2390-2398, 10.1016/j.str.2024.10.009, 39510075
High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum
Publikation
Johannsen S,
Gierse R,
Krüger A,
Edwards R,
Nanna V,
Fontana A,
Di Zhu,
Masini T,
Carvalho L,
Poizat M,
Kieftenbelt B,
Hodge D,
Alvarez S,
Bunt D,
Lacour A,
Shams A,
Meissner K,
Souza E,
Dröge M,
van Vliet B,
Hartog J,
Hutter M,
Held J,
Odom John A,
Wrenger C,
Hirsch* A
(2024)
ACS Infect. Dis., 10.1021/acsinfecdis.3c00670, 38367280
ACS Infect. Dis., 10.1021/acsinfecdis.3c00670, 38367280
Targeting the Plasmodium falciparum IspE Enzyme
Publikation
Diamanti E,
Steinbach A,
Carvalho L,
Ropponen H,
Lacour A,
Hamid R,
Eisa S,
Bravo P,
Bousis S,
Illarionov B,
Fischer M,
Hamed M,
Bach N,
Rottmann M,
Held J,
Witschel M,
Sieber S,
Hirsch A
(2024)
ACS omega, 9, 44, 44465-44473, 10.1021/acsomega.4c06038, 39524657
ACS omega, 9, 44, 44465-44473, 10.1021/acsomega.4c06038, 39524657
Behavioral and electrophysiological responses of the male medfly, Ceratitis capitata, to thymol and carvacrol ethers
Publikation
Tabanca N,
Cloonan K,
Nesterkina M,
Gill M,
Montgomery W,
Kravchenko I,
Kendra P
(2024)
Pest management science, 10.1002/ps.8324, 39096116
Pest management science, 10.1002/ps.8324, 39096116
Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes
Publikation
Chan A,
Ho T,
Fathoni I,
Hamid R,
Hirsch A,
Saliba K,
Leeper F
(2024)
RSC Med. Chem., 15, 5, 1773-1781, 10.1039/D4MD00083H, 38784473
RSC Med. Chem., 15, 5, 1773-1781, 10.1039/D4MD00083H, 38784473
Studying Target-Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry
Publikation
Bizzarri L,
Steinbrunn D,
Quennesson T,
Lacour A,
Bianchino G,
Bravo P,
Chaignon P,
Lohse J,
Mäser P,
Seemann M,
van Calenbergh S,
Hirsch A,
Hahne H
(2024)
ACS Infect. Dis., 10, 12, 4087-4102, 10.1021/acsinfecdis.4c00417, 39566904
ACS Infect. Dis., 10, 12, 4087-4102, 10.1021/acsinfecdis.4c00417, 39566904
Design and Optimization of Simplified Inhibitors Targeting E. coli and K. pneumoniae IspE
Publikation
Walsh D,
Hamid R,
Giele T,
Rottmann M,
Hirsch A,
Hamed M,
Reiling N
(2026)
RSC Med. Chem., 10.1039/D5MD00874C
RSC Med. Chem., 10.1039/D5MD00874C
From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds
Publikation
Keddis P,
My Tu T,
Scherer H,
Kany A,
Hafez D,
Darwish S,
Abadi A,
Hirsch A,
Engel M,
Hamed M,
Horng J,
Abdel-Halim M
(2025)
Eur. J. Med. Chem., 287, 10.1016/j.ejmech.2025.117348, 39947051
Eur. J. Med. Chem., 287, 10.1016/j.ejmech.2025.117348, 39947051
Apo structure of Mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate synthase DXPS: Dynamics and implications for inhibitor design
Publikation
Gawriljuk V,
Alhayek A,
Hirsch A,
Groves M
(2025)
Biochemical and Biophysical Research Communications, 747, 10.1016/j.bbrc.2024.151246
Biochemical and Biophysical Research Communications, 747, 10.1016/j.bbrc.2024.151246