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Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin‐Wound Infections
Publikation
Alhayek A,
Khan E,
Schönauer E,
Däinghaus T,
Shafiei R,
Voos K,
Han M,
Ducho C,
Posselt G,
Wessler S,
Brandstetter H,
Haupenthal J,
del Campo A,
Hirsch A
(2022)
Adv. Therap., 10.1002/adtp.202100222
Adv. Therap., 10.1002/adtp.202100222
Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor
Publikation
Drost M,
Diamanti E,
Fuhrmann K,
Goes A,
Shams A,
Haupenthal J,
Koch M,
Hirsch A,
Fuhrmann G
(2022)
Pharmaceutics, 14, 1, 10.3390/pharmaceutics14010004
Pharmaceutics, 14, 1, 10.3390/pharmaceutics14010004
Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors
Publikation
Wimmer S,
Hoff K,
Martin B,
Grewer M,
Denni L,
Lascorz Massanet R,
Raimondi M,
Bülbül E,
Melesina J,
Hotop S,
Haupenthal J,
Rohde H,
Heisig P,
Hirsch A,
Brönstrup M,
Sippl W,
Holl R
(2022)
Bioorganic chemistry, 131, 10.1016/j.bioorg.2022.106331, 36587505
Bioorganic chemistry, 131, 10.1016/j.bioorg.2022.106331, 36587505
New Ketene Dithioacetals Generated from 2-Nitroperchlorobutadiene and Investigation of Their Antibacterial, Antifungal, Anticonvulsant and Antidepressant Activities
Publikation
Aydinli S,
Bulut E,
Deniz N,
Sayil C,
Komarovska-Porokhnyavets O,
Lubenets V,
Zvarych V,
Stasevych M,
Nesterkina M,
Kravchenko I
(2022)
Chemistry & Biodiversity, 19, 7, 10.1002/cbdv.202100931, 35674435
Chemistry & Biodiversity, 19, 7, 10.1002/cbdv.202100931, 35674435
Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases
Publikation
Alhayek A,
Abdelsamie A,
Schönauer E,
Camberlein V,
Hutterer E,
Posselt G,
Serwanja J,
Blöchl C,
Huber C,
Haupenthal J,
Brandstetter H,
Wessler S,
Hirsch A
(2022)
Journal of medicinal chemistry, 65, 19, 12933-12955, 10.1021/acs.jmedchem.2c00785, 36154055
Journal of medicinal chemistry, 65, 19, 12933-12955, 10.1021/acs.jmedchem.2c00785, 36154055
(1 R ,2 S ,5 R )-5-Methyl-2-(propan-2-yl)cyclohexyl 4-amino-3-phenylbutanoate hydrochloride: Synthesis and anticonvulsant activity
Publikation
Nesterkina M,
Musatov V,
Honcharova O,
Kravchenko I
(2022)
Open Chemistry, 20, 1, 703-707, 10.1515/chem-2022-0189
Open Chemistry, 20, 1, 703-707, 10.1515/chem-2022-0189
Design and Optimization of Simplified Inhibitors Targeting E. coli and K. pneumoniae IspE
Publikation
Walsh D,
Hamid R,
Giele T,
Rottmann M,
Hirsch A,
Hamed M,
Reiling N
(2026)
RSC Med. Chem., 17, 3, 10.1039/D5MD00874C
RSC Med. Chem., 17, 3, 10.1039/D5MD00874C
From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds
Publikation
Keddis P,
My Tu T,
Scherer H,
Kany A,
Hafez D,
Darwish S,
Abadi A,
Hirsch A,
Engel M,
Hamed M,
Horng J,
Abdel-Halim M
(2025)
Eur. J. Med. Chem., 287, 10.1016/j.ejmech.2025.117348, 39947051
Eur. J. Med. Chem., 287, 10.1016/j.ejmech.2025.117348, 39947051
Apo structure of Mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate synthase DXPS: Dynamics and implications for inhibitor design
Publikation
Gawriljuk V,
Alhayek A,
Hirsch A,
Groves M
(2025)
Biochemical and Biophysical Research Communications, 747, 10.1016/j.bbrc.2024.151246
Biochemical and Biophysical Research Communications, 747, 10.1016/j.bbrc.2024.151246
Targeting IspD for Anti-infective and Herbicide Development: Exploring Its Role, Mechanism, and Structural Insights
Publikation
Willocx D,
Diamanti E,
Hirsch A
(2025)
Journal of medicinal chemistry, 10.1021/acs.jmedchem.4c01146, 39749898
Journal of medicinal chemistry, 10.1021/acs.jmedchem.4c01146, 39749898