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Rheological Properties of Hyaluronic Acid Diluted Solutions as Components of Cosmetics
Publikation
Svetlana Saitarly,
Yuriy Pushkarev,
Nesterkina M,
Serhat Öztürk,
Iryna Kravchenko
(2021)
Biointerface Res Appl Chem, 12, 2, 1907-1915, 10.33263/BRIAC122.19071915
Biointerface Res Appl Chem, 12, 2, 1907-1915, 10.33263/BRIAC122.19071915
Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties
Publikation
Gierse R,
Reddem E,
Alhayek A,
Baitinger D,
Hamid Z,
Jakobi H,
Laber B,
Lange G,
Hirsch A,
Groves
(2021)
Biochemical and Biophysical Research Communications, 539, 10.1016/j.bbrc.2020.12.069, 33421767
Biochemical and Biophysical Research Communications, 539, 10.1016/j.bbrc.2020.12.069, 33421767
Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors
Publikation
Kaya C,
Walter I,
Yahiaoui S,
Sikandar A,
Alhayek A,
Konstantinovic J,
Kany A,
Haupenthal J,
Köhnke J,
Hartmann R,
Hirsch A
(2021)
Angewandte Chemie (International ed. in English), 10.1002/anie.202112295, 34762767
Angewandte Chemie (International ed. in English), 10.1002/anie.202112295, 34762767
Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design
Publikation
Axer A,
Jumde R,
Adam S,
Faust A,
Schäfers M,
Fobker M,
Koehnke J,
Hirsch A,
Gilmour R
(2021)
Chem. Sci., 12, 4, 1286-1294, 10.1039/D0SC04297H
Chem. Sci., 12, 4, 1286-1294, 10.1039/D0SC04297H
N-Phenyl-3-Mercaptopropanamide Derivatives as Metallo-Beta-Lactamase Inhibitors for the Treatment of Bacterial Infections
Publikation
Hartmann R,
Konstantinovic J,
Haupenthal J,
Hirsch A,
Kany A,
Kaya C,
Yahiaoui S,
Wichelhaus T,
Proschak E
(2021)
Patent, A61K31/5375; A61P31/04; C07C233/15; C07C233/25; C07C233/33; C07C233/43; C07C233/54; C07C319/02; C07C323/52; C07D295/22;, WO2021191219A1
Patent, A61K31/5375; A61P31/04; C07C233/15; C07C233/25; C07C233/33; C07C233/43; C07C233/54; C07C319/02; C07C323/52; C07D295/22;, WO2021191219A1
Novel PqsR Inverse Agonists
Publikation
Hamed M,
Ahmed S,
Empting. M.,
Schütz C,
Hartmann R,
Röhrig T,
Kany A,
Hirsch A
(2021)
Patent, A61K31/4439; A61P31/04; C07D401/14; C07D417/14;, WO2021136805A1
Patent, A61K31/4439; A61P31/04; C07D401/14; C07D417/14;, WO2021136805A1
N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa
Publikation
Yahiaoui S,
Voos K,
Haupenthal J,
Wichelhaus T,
Frank D,
Weizel L,
Rotter M,
Brunst S,
Kramer J,
Proschak E,
Ducho C,
Hirsch A
(2021)
RSC Med. Chem., 10.1039/D1MD00187F
RSC Med. Chem., 10.1039/D1MD00187F
Hit-optimization using target-directed dynamic combinatorial chemistry: Development of inhibitors of the anti-infective target 1-deoxy-D-xylulose-5-phosphate synthase
Publikation
Jumde R,
Guadigni M,
Gierse R,
Alhayek A,
Di Zhu,
Hamid Z,
Johannsen S,
Elgaher W,
Neusens P,
Nehls C,
Haupenthal J,
Reiling N,
Hirsch A
(2021)
Chemical Science, 10.1039/D1SC00330E
Chemical Science, 10.1039/D1SC00330E
Citatronic Acid and Derivates thereof for use as a medicament
Publikation
Pessler F.,
Chen F.,
Winterhoff M.,
Büssow K.,
Blankenfeldt W.,
Hirsch A. K. H.,
Elgaher W
(2021)
Patent, WO2022223778, 2022
Patent, WO2022223778, 2022
Crystalline sponge affinity screening: A fast tool for soaking condition optimization without the need of X-ray diffraction analysis
Publikation
Rosenberger L,
Essen C,
Khutia A,
Kühn C,
Georgi K,
Hirsch A,
Hartmann R,
Badolo L
(2021)
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 164, 10.1016/j.ejps.2021.105884, 34161782
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 164, 10.1016/j.ejps.2021.105884, 34161782