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Structural analysis of 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding
Publikation
Hamid R,
Adam S,
Lacour A,
Gomez L,
Hirsch A
(2022)
bioRxiv, 10.1101/2022.07.04.498669
bioRxiv, 10.1101/2022.07.04.498669
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism
Publikation
Chen F,
Elgaher W,
Winterhoff M,
Büssow K,
Waqas F,
Graner E,
Pires-Afonso Y,
Casares Perez L,
La Vega L,
Sahini N,
Czichon L,
Zobl W,
Zillinger T,
Shehata M,
Pleschka S,
Bähre H,
Falk C,
Michelucci A,
Schuchardt S,
Blankenfeldt W,
Hirsch A,
Pessler F
(2022)
Nature metabolism, 4, 5, 534-546, 10.1038/s42255-022-00577-x, 35655026
Nature metabolism, 4, 5, 534-546, 10.1038/s42255-022-00577-x, 35655026
Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents
Publikation
Kaya C,
Hirsch A
(2022)
Chimia, 76, 5, 10.2533/chimia.2022.402
Chimia, 76, 5, 10.2533/chimia.2022.402
Screening of Natural Products and Small Molecules Uncovers Novel Coronavirus 1a/1b Frameshifting Inhibitors with Antiviral Properties
Publikation
Kibe A,
Elgaher W,
Rand U,
Zimmer M,
Kany A,
Hermann J,
Müller R,
Cicin-Sain L,
Hirsch A,
Caliskan N
(2022)
SSRN Journal, 10.2139/ssrn.4157446
SSRN Journal, 10.2139/ssrn.4157446
Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages
Publikation
Sake S,
Kosch C,
Blockus S,
Haid S,
Gunesch A,
Zhang X,
Friesland M,
Trummer S,
Grethe C,
Kühnel A,
Rückert J,
Duprex W,
Huang J,
Rameix-Welti M,
Empting M,
Fischer N,
Hirsch A,
Schulz T,
Pietschmann T
(2022)
Antimicrobial agents and chemotherapy, 10.1128/aac.01032-22, 36346232
Antimicrobial agents and chemotherapy, 10.1128/aac.01032-22, 36346232
Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry
Publikation
Bagnolini G,
Balboni B,
Schipani F,
Gioia D,
Veronesi M,
Franco F,
Kaya C,
Jumde R,
Ortega J,
Girotto S,
Hirsch A,
Roberti M,
Cavalli A
(2022)
ACS Med. Chem. Lett., 13, 8, 1262-1269, 10.1021/acsmedchemlett.2c00063, 35978685
ACS Med. Chem. Lett., 13, 8, 1262-1269, 10.1021/acsmedchemlett.2c00063, 35978685
Simultaneous Complexation and Microextraction Using Verbenone Hydrazone as the Ligand with Slotted Quartz Tube-Flame Atomic Absorption Spectrometry (FAAS) for the Sensitive Determination of Copper
Publikation
Özzeybek G,
Borahan T,
Nesterkina M,
Kravchenko I,
Bakirdere S
(2021)
Analytical letters, 54, 14, 2376-2386, 10.1080/00032719.2020.1866594
Analytical letters, 54, 14, 2376-2386, 10.1080/00032719.2020.1866594
Unveiling Adatoms in On-Surface Reactions: Combining Scanning Probe Microscopy with van't Hoff Plots
Publikation
Moreno-López J,
Pérez Paz A,
Gottardi S,
Solianyk L,
Li J,
Monjas L,
Hirsch A,
Mowbray D,
Stöhr M
(2021)
The journal of physical chemistry. C, Nanomaterials and interfaces, 125, 18, 9847-9854, 10.1021/acs.jpcc.1c03134, 34276856
The journal of physical chemistry. C, Nanomaterials and interfaces, 125, 18, 9847-9854, 10.1021/acs.jpcc.1c03134, 34276856
New PqsR Inverse Agonist
Publikation
Schütz C,
Empting M,
Ahmed S,
Hamed M,
Hartmann R,
Röhrig T,
Kany A,
Hirsch A
(2021)
Patent, A61K31/4439; A61K31/506; A61P31/04; C07D401/12; C07D403/12;, WO2021136803A1
Patent, A61K31/4439; A61K31/506; A61P31/04; C07D401/12; C07D403/12;, WO2021136803A1
Quantitative structure–activity relationship study on prolonged anticonvulsant activity of terpene derivatives in pentylenetetrazole test
Publikation
Nesterkina M,
Muratov V,
Ognichenko L,
Kravchenko I,
Kuz’min V
(2021)
Open Chemistry, 19, 1, 1184-1192, 10.1515/chem-2021-0108
Open Chemistry, 19, 1, 1184-1192, 10.1515/chem-2021-0108