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Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages
Publikation
Sake S,
Kosch C,
Blockus S,
Haid S,
Gunesch A,
Zhang X,
Friesland M,
Trummer S,
Grethe C,
Kühnel A,
Rückert J,
Duprex W,
Huang J,
Rameix-Welti M,
Empting M,
Fischer N,
Hirsch A,
Schulz T,
Pietschmann T
(2022)
Antimicrobial agents and chemotherapy, 10.1128/aac.01032-22, 36346232
Antimicrobial agents and chemotherapy, 10.1128/aac.01032-22, 36346232
Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry
Publikation
Bagnolini G,
Balboni B,
Schipani F,
Gioia D,
Veronesi M,
Franco F,
Kaya C,
Jumde R,
Ortega J,
Girotto S,
Hirsch A,
Roberti M,
Cavalli A
(2022)
ACS Med. Chem. Lett., 13, 8, 1262-1269, 10.1021/acsmedchemlett.2c00063, 35978685
ACS Med. Chem. Lett., 13, 8, 1262-1269, 10.1021/acsmedchemlett.2c00063, 35978685
Rheological Properties of Hyaluronic Acid Diluted Solutions as Components of Cosmetics
Publikation
Svetlana Saitarly,
Yuriy Pushkarev,
Nesterkina M,
Serhat Öztürk,
Iryna Kravchenko
(2021)
Biointerface Res Appl Chem, 12, 2, 1907-1915, 10.33263/BRIAC122.19071915
Biointerface Res Appl Chem, 12, 2, 1907-1915, 10.33263/BRIAC122.19071915
Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties
Publikation
Gierse R,
Reddem E,
Alhayek A,
Baitinger D,
Hamid Z,
Jakobi H,
Laber B,
Lange G,
Hirsch A,
Groves
(2021)
Biochemical and Biophysical Research Communications, 539, 10.1016/j.bbrc.2020.12.069, 33421767
Biochemical and Biophysical Research Communications, 539, 10.1016/j.bbrc.2020.12.069, 33421767
Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors
Publikation
Kaya C,
Walter I,
Yahiaoui S,
Sikandar A,
Alhayek A,
Konstantinovic J,
Kany A,
Haupenthal J,
Köhnke J,
Hartmann R,
Hirsch A
(2021)
Angewandte Chemie (International ed. in English), 10.1002/anie.202112295, 34762767
Angewandte Chemie (International ed. in English), 10.1002/anie.202112295, 34762767
Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design
Publikation
Axer A,
Jumde R,
Adam S,
Faust A,
Schäfers M,
Fobker M,
Koehnke J,
Hirsch A,
Gilmour R
(2021)
Chem. Sci., 12, 4, 1286-1294, 10.1039/D0SC04297H
Chem. Sci., 12, 4, 1286-1294, 10.1039/D0SC04297H
N-Phenyl-3-Mercaptopropanamide Derivatives as Metallo-Beta-Lactamase Inhibitors for the Treatment of Bacterial Infections
Publikation
Hartmann R,
Konstantinovic J,
Haupenthal J,
Hirsch A,
Kany A,
Kaya C,
Yahiaoui S,
Wichelhaus T,
Proschak E
(2021)
Patent, A61K31/5375; A61P31/04; C07C233/15; C07C233/25; C07C233/33; C07C233/43; C07C233/54; C07C319/02; C07C323/52; C07D295/22;, WO2021191219A1
Patent, A61K31/5375; A61P31/04; C07C233/15; C07C233/25; C07C233/33; C07C233/43; C07C233/54; C07C319/02; C07C323/52; C07D295/22;, WO2021191219A1
Novel PqsR Inverse Agonists
Publikation
Hamed M,
Ahmed S,
Empting. M.,
Schütz C,
Hartmann R,
Röhrig T,
Kany A,
Hirsch A
(2021)
Patent, A61K31/4439; A61P31/04; C07D401/14; C07D417/14;, WO2021136805A1
Patent, A61K31/4439; A61P31/04; C07D401/14; C07D417/14;, WO2021136805A1
N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa
Publikation
Yahiaoui S,
Voos K,
Haupenthal J,
Wichelhaus T,
Frank D,
Weizel L,
Rotter M,
Brunst S,
Kramer J,
Proschak E,
Ducho C,
Hirsch A
(2021)
RSC Med. Chem., 10.1039/D1MD00187F
RSC Med. Chem., 10.1039/D1MD00187F
Hit-optimization using target-directed dynamic combinatorial chemistry: Development of inhibitors of the anti-infective target 1-deoxy-D-xylulose-5-phosphate synthase
Publikation
Jumde R,
Guadigni M,
Gierse R,
Alhayek A,
Di Zhu,
Hamid Z,
Johannsen S,
Elgaher W,
Neusens P,
Nehls C,
Haupenthal J,
Reiling N,
Hirsch A
(2021)
Chemical Science, 10.1039/D1SC00330E
Chemical Science, 10.1039/D1SC00330E