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François Diederich – In Memoriam**
Publikation
Hof F,
Hirsch A
(2020)
ChemMedChem, 10.1002/cmdc.202000920
ChemMedChem, 10.1002/cmdc.202000920
BOPC1 Enantiomers Preparation and HuR Interaction Study. From Molecular Modeling to a Curious DEEP-STD NMR Application
Publikation
Della Volpe S,
Listro R,
Parafioriti M,
Di Giacomo M,
Rossi D,
Ambrosio F,
Costa G,
Alcaro S,
Ortuso F,
Hirsch A,
Vasile F,
Collina S
(2020)
ACS medicinal chemistry letters, 11, 5, 883-888, 10.1021/acsmedchemlett.9b00659, 32435400
ACS medicinal chemistry letters, 11, 5, 883-888, 10.1021/acsmedchemlett.9b00659, 32435400
Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach
Publikation
Konstantinidou M,
Magari F,
Sutanto F,
Haupenthal J,
Jumde R,
Ünver M,
Heine A,
Camacho C,
Hirsch A,
Klebe G,
Dömling A
(2020)
ChemMedChem, 15, 8, 680-684, 10.1002/cmdc.202000024
ChemMedChem, 15, 8, 680-684, 10.1002/cmdc.202000024
Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus-Based Wound Infection Model in SKH1 Mice
Publikation
Haupenthal J,
Kautz Y,
Elgaher W,
Pätzold L,
Röhrig T,
Laschke M,
Tschernig T,
Hirsch A,
Molodtsov V,
Murakami K,
Hartmann R,
Bischoff M
(2020)
ACS infectious diseases, 6, 10, 2573-2581, 10.1021/acsinfecdis.0c00034, 32886885
ACS infectious diseases, 6, 10, 2573-2581, 10.1021/acsinfecdis.0c00034, 32886885
Camelid and shark single domain antibodies: structural features and therapeutic potential
Publikation
Könning D,
Zielonka S,
Grzeschik J,
Empting M,
Valldorf B,
Krah S,
Schröter C,
Sellmann C,
Hock B,
Kolmar H
(2017)
Current opinion in structural biology, 45, 10-16, 10.1016/j.sbi.2016.10.019, 27865111
Current opinion in structural biology, 45, 10-16, 10.1016/j.sbi.2016.10.019, 27865111
Designed Spiroketal Protein Modulation
Publikation
Scheepstra M,
Andrei S,
Unver M,
Hirsch A,
Leysen S,
Ottmann C,
Brunsveld L,
Milroy L
(2017)
Angewandte Chemie (International ed. in English), 56, 20, 5480-5484, 10.1002/anie.201612504, 28407400
Angewandte Chemie (International ed. in English), 56, 20, 5480-5484, 10.1002/anie.201612504, 28407400
Design and synthesis of thiamine analogues to study their binding to the ECF transporter for thiamine in bacteria
Publikation
Monjas L,
Swier L,
Voogd A,
Oudshoorn R,
Hirsch A,
Slotboom D
(2016)
Med. Chem. Commun., 7, 5, 966-971, 10.1039/C6MD00022C
Med. Chem. Commun., 7, 5, 966-971, 10.1039/C6MD00022C
Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds
Publikation
Zender M,
Witzgall F,
Drees S,
Weidel E,
Maurer C,
Fetzner S,
Blankenfeldt W,
Empting M,
Hartmann R
(2016)
ACS chemical biology, 10.1021/acschembio.6b00156, 27082157
ACS chemical biology, 10.1021/acschembio.6b00156, 27082157
Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors
Publikation
Elgaher W,
Sharma K,
Haupenthal J,
Saladini F,
Pires M,
Real E,
Mely Y,
Hartmann R
(2016)
Journal of medicinal chemistry, 10.1021/acs.jmedchem.6b00730, 27339173
Journal of medicinal chemistry, 10.1021/acs.jmedchem.6b00730, 27339173
Structure-Activity Relationships of 2-Sufonylpyrimidines as Quorum-Sensing Inhibitors to Tackle Biofilm Formation and eDNA Release of Pseudomonas aeruginosa
Publikation
Thomann A,
Brengel C,
Börger C,
Kail D,
Steinbach A,
Empting M,
Hartmann R
(2016)
ChemMedChem, 11, 22, 2522-2533, 10.1002/cmdc.201600419, 27731921
ChemMedChem, 11, 22, 2522-2533, 10.1002/cmdc.201600419, 27731921