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Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors
Publikation
Hamdy J,
Emadeldin N,
Hamed M,
Frakolaki E,
Katsamakas S,
Vassilaki N,
Zoidis G,
Hirsch A,
Abdel-Halim M,
Abadi A
(2022)
Pharmaceuticals, 15, 5, 10.3390/ph15050632, 35631457
Pharmaceuticals, 15, 5, 10.3390/ph15050632, 35631457
N-Aryl-2-iso-butylmercaptoacetamides: the discovery of highly potent and selective inhibitors of Pseudomonas aeruginosa virulence factor LasB and Clostridium histolyticum virulence factor ColH
Publikation
Voos K,
Yahiaoui S,
Konstantinovic J,
Schönauer E,
Alhayek A,
Sikandar A,
Si Chaib K,
Ramspoth T,
Rox K,
Haupenthal J,
Köhnke J,
Brandstetter H,
Ducho C,
Hirsch A
(2022)
ChemRxiv, 10.26434/chemrxiv-2022-fjrqr
ChemRxiv, 10.26434/chemrxiv-2022-fjrqr
Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin‐Wound Infections
Publikation
Alhayek A,
Khan E,
Schönauer E,
Däinghaus T,
Shafiei R,
Voos K,
Han M,
Ducho C,
Posselt G,
Wessler S,
Brandstetter H,
Haupenthal J,
del Campo A,
Hirsch A
(2022)
Adv. Therap., 10.1002/adtp.202100222
Adv. Therap., 10.1002/adtp.202100222
Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor
Publikation
Drost M,
Diamanti E,
Fuhrmann K,
Goes A,
Shams A,
Haupenthal J,
Koch M,
Hirsch A,
Fuhrmann G
(2022)
Pharmaceutics, 14, 1, 10.3390/pharmaceutics14010004
Pharmaceutics, 14, 1, 10.3390/pharmaceutics14010004
1-Deoxy-D-xylulose 5-phosphate synthase: structural perspectives on an essential enzyme in isoprenoid biosynthesis
Publikation
Gawriljuk V,
Oerlemans R,
Reddem E,
Gierse R,
Hirsch A,
Groves M
(2025)
J. Struct. Biol., 217, 3, 10.1016/j.jsb.2025.108236, 40784416
J. Struct. Biol., 217, 3, 10.1016/j.jsb.2025.108236, 40784416
Domain adaptable language modeling of chemical compounds identifies potent pathoblockers for Pseudomonas aeruginosa
Publikation
Kallergis G,
Asgari E,
Empting M,
Hirsch A,
Klawonn F,
McHardy A
(2025)
Commun. Chem., 8, 1, 10.1038/s42004-025-01484-4, 40216964
Commun. Chem., 8, 1, 10.1038/s42004-025-01484-4, 40216964
Modular synthetic routes to biologically active indoles from lignin
Publikation
Castillo-Garcia A,
Haupenthal J,
Hirsch A,
Barta K
(2025)
Green Chem., 27, 25, 7506-7512, 10.1039/d5gc01003a, 40510740
Green Chem., 27, 25, 7506-7512, 10.1039/d5gc01003a, 40510740
Positive Charge in an Antimalarial Compound Unlocks Broad-Spectrum Antibacterial Activity
Publikation
Braun-Cornejo M,
Platteschorre M,
Vries V,
Bravo P,
Sonawane V,
Hamed M,
Haupenthal J,
Reiling N,
Rottmann M,
Piet D,
Maas P,
Diamanti E,
Hirsch A
(2025)
JACS Au, 5, 3, 1146-1156, 10.1021/jacsau.4c00935, 40151263
JACS Au, 5, 3, 1146-1156, 10.1021/jacsau.4c00935, 40151263
A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum
Publikation
Bravo P,
Diamanti E,
Hamed M,
Bizzarri L,
Wiedemar N,
Passecker A,
Brancucci N,
Albisetti A,
Gumpp C,
Illarionov B,
Fischer M,
Witschel M,
Schehl T,
Hahne H,
Mäser P,
Rottmann M,
Hirsch A
(2025)
Angew. Chem. Int. Ed., 64, 10.1002/anie.202514085, 41116297
Angew. Chem. Int. Ed., 64, 10.1002/anie.202514085, 41116297
Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity
Publikation
Mielniczuk S,
Hoff K,
Baselious F,
Li Y,
Haupenthal J,
Kany A,
Riedner M,
Rohde H,
Rox K,
Hirsch A,
Krimm I,
Sippl W,
Holl R
(2024)
Journal of medicinal chemistry, 67, 19, 17363-17391, 10.1021/acs.jmedchem.4c01262, 39303295
Journal of medicinal chemistry, 67, 19, 17363-17391, 10.1021/acs.jmedchem.4c01262, 39303295