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Selective Activation of TRPC6 Ion Channel by Metallated Type-B Polyprenylated Polycyclic Acylphloroglucinols
Publikation
Peslalz P,
Kraus F,
Izzo F,
Bleisch A,
El Hamdaoui Y,
Schulz I,
Kany A,
Hirsch A,
Friedland K,
Plietker B
(2023)
Manuscript, 10.26434/chemrxiv-2023-6w94r
Manuscript, 10.26434/chemrxiv-2023-6w94r
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle
Publikation
Hamed M,
Abdelsamie A,
Rox K,
Schütz C,
Kany A,
Röhrig T,
Schmelz S,
Blankenfeldt W,
Arce-Rodriguez A,
Borrero-de Acuña J,
Jahn D,
Rademacher J,
Ringshausen F,
Cramer N,
Tümmler B,
Hirsch A,
Hartmann R,
Empting M
(2023)
Adv. Sci., Online, 10.1002/advs.202204443
Adv. Sci., Online, 10.1002/advs.202204443
Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation
Publikation
Chan A,
Ho T,
Irfan R,
Hamid R,
Rudge E,
Iqbal A,
Turner A,
Hirsch A.,
Leeper F
(2023)
Bioorganic chemistry, 138, 10.1016/j.bioorg.2023.106602
Bioorganic chemistry, 138, 10.1016/j.bioorg.2023.106602
1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding
Publikation
Hamid R,
Adam S,
Lacour A,
Monjas L,
Köhnke J,
Hirsch A
(2023)
The Journal of biological chemistry, 10.1016/j.jbc.2023.105152, 37567475
The Journal of biological chemistry, 10.1016/j.jbc.2023.105152, 37567475
Identification of HuR–RNA Interfering Compounds by Dynamic Combinatorial Chemistry and Fluorescence Polarization
Publikation
Della Volpe S,
Listro R,
Ambrosio F,
Garbagnoli M,
Linciano P,
Rossi D,
Costa G,
Alcaro S,
Vasile F,
Hirsch A,
Collina S
(2023)
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.3c00303
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.3c00303
NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner
Publikation
Waqas F,
Shehata M,
Elgaher W,
Lacour A,
Kurmasheva N,
Begnini F,
Kiib A,
Dahlmann J,
Chen C,
Pavlou A,
Poulsen T,
Merkert S,
Martin U,
Olmer R,
Olagnier D,
Hirsch A,
Pleschka S,
Pessler F
(2023)
PLOS Pathogens, 19, 7, 10.1371/journal.ppat.1011506, 37459366
PLOS Pathogens, 19, 7, 10.1371/journal.ppat.1011506, 37459366
Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate
Publikation
Gawriljuk V,
Oerlemans R,
Gierse R,
Jotwani R,
Hirsch A,
Groves M
(2023)
Crystals, 13, 5, 10.3390/cryst13050737
Crystals, 13, 5, 10.3390/cryst13050737
The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB
Publikation
Camberlein V,
Jézéquel G,
Haupenthal J,
Hirsch A
(2022)
Antibiotics, 11, 8, 10.3390/antibiotics11081060
Antibiotics, 11, 8, 10.3390/antibiotics11081060
Design, Synthesis, Antimicrobial Activity, and Molecular Docking of Some New Diclofenac Derivatives
Publikation
Tolba M,
Hamed M,
Sayed M,
Kamal El-Dean A,
Abdel-Mohsen S,
Ibrahim O,
Elgaher W,
Hirsch A,
Saddik A
(2022)
Polycyclic Aromatic Compounds, 1-16, 10.1080/10406638.2022.2102661
Polycyclic Aromatic Compounds, 1-16, 10.1080/10406638.2022.2102661
N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases
Publikation
Kaya C,
Konstantinovic J,
Kany A,
Andreas A,
Kramer J,
Brunst S,
Weizel L,
Rotter M,
Frank D,
Yahiaoui S,
Müller R,
Hartmann R,
Haupenthal J,
Proschak E,
Wichelhaus T,
Hirsch A
(2022)
Journal of medicinal chemistry, 65, 5, 3913-3922, 10.1021/acs.jmedchem.1c01755, 35188771
Journal of medicinal chemistry, 65, 5, 3913-3922, 10.1021/acs.jmedchem.1c01755, 35188771