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Composing compound libraries for hit discovery--rationality-driven preselection or random choice by structural diversity?
Publikation
Weidel E,
Negri M,
Empting M,
Hinsberger S,
Hartmann R
(2014)
Future medicinal chemistry, 6, 18, 2057-72, 10.4155/fmc.14.142, 25531968
Future medicinal chemistry, 6, 18, 2057-72, 10.4155/fmc.14.142, 25531968
Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections
Publikation
Hinsberger S,
Jong J,
Groh M,
Haupenthal J,
Hartmann R
(2014)
European journal of medicinal chemistry, 76, 343-51, 10.1016/j.ejmech.2014.02.014, 24589489
European journal of medicinal chemistry, 76, 343-51, 10.1016/j.ejmech.2014.02.014, 24589489
Synthesis, Physicochemical Properties, and Anticonvulsant Activity of the Gaba Complex with a Calix[4]Arene derivative
Publikation
Nesterkina M,
Alekseeva E,
Kravchenko I
(2014)
Pharm Chem J, 48, 2, 82-84, 10.1007/s11094-014-1052-4
Pharm Chem J, 48, 2, 82-84, 10.1007/s11094-014-1052-4
Potent inhibitors of human matriptase-1 based on the scaffold of sunflower trypsin inhibitor
Publikation
Fittler H,
Avrutina O,
Empting M,
Kolmar H
(2014)
Journal of peptide science : an official publication of the European Peptide Society, 20, 6, 415-20, 10.1002/psc.2629, 24723440
Journal of peptide science : an official publication of the European Peptide Society, 20, 6, 415-20, 10.1002/psc.2629, 24723440
Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents
Publikation
Masini T,
Hirsch A
(2014)
Journal of medicinal chemistry, 57, 23, 9740-63, 10.1021/jm5010978, 25210872
Journal of medicinal chemistry, 57, 23, 9740-63, 10.1021/jm5010978, 25210872
Between two worlds: a comparative study on in vitro and in silico inhibition of trypsin and matriptase by redox-stable SFTI-1 variants at near physiological pH
Publikation
Avrutina O,
Fittler H,
Glotzbach B,
Kolmar H,
Empting M
(2012)
Org. Biomol. Chem., 10, 38, 7753-62, 10.1039/c2ob26162f, 22903577
Org. Biomol. Chem., 10, 38, 7753-62, 10.1039/c2ob26162f, 22903577
Biodynamers: self-organization-driven formation of doubly dynamic proteoids
Publikation
Hirsch A,
Buhler E,
Lehn J
(2012)
Journal of the American Chemical Society, 134, 9, 4177-83, 10.1021/ja2099134, 22300496
Journal of the American Chemical Society, 134, 9, 4177-83, 10.1021/ja2099134, 22300496
Braces for the peptide backbone: insights into structure-activity relationships of protease inhibitor mimics with locked amide conformations
Publikation
Tischler M,
Nasu D,
Empting M,
Schmelz S,
Heinz D,
Rottmann P,
Kolmar H,
Buntkowsky G,
Tietze D,
Avrutina O
(2012)
Angewandte Chemie (International ed. in English), 51, 15, 3708-12, 10.1002/anie.201108983, 22374650
Angewandte Chemie (International ed. in English), 51, 15, 3708-12, 10.1002/anie.201108983, 22374650
Total synthesis of (-)-doliculide, structure-activity relationship studies and its binding to F-actin
Publikation
Matcha K,
Madduri A,
Roy S,
Ziegler S,
Waldmann H,
Hirsch A,
Minnaard A
(2012)
ChemBioChem, 13, 17, 2537-48, 10.1002/cbic.201200512, 23129522
ChemBioChem, 13, 17, 2537-48, 10.1002/cbic.201200512, 23129522
'Triazole bridge': disulfide-bond replacement by ruthenium-catalyzed formation of 1,5-disubstituted 1,2,3-triazoles
Publikation
Empting M,
Avrutina O,
Meusinger R,
Fabritz S,
Reinwarth M,
Biesalski M,
Voigt S,
Buntkowsky G,
Kolmar H
(2011)
Angewandte Chemie (International ed. in English), 50, 22, 5207-11, 10.1002/anie.201008142, 21544910
Angewandte Chemie (International ed. in English), 50, 22, 5207-11, 10.1002/anie.201008142, 21544910