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Hit-optimization using target-directed dynamic combinatorial chemistry: Development of inhibitors of the anti-infective target 1-deoxy-D-xylulose-5-phosphate synthase
Publikation
Jumde R,
Guadigni M,
Gierse R,
Alhayek A,
Di Zhu,
Hamid Z,
Johannsen S,
Elgaher W,
Neusens P,
Nehls C,
Haupenthal J,
Reiling N,
Hirsch A
(2021)
Chemical Science, 10.1039/D1SC00330E
Chemical Science, 10.1039/D1SC00330E
Citatronic Acid and Derivates thereof for use as a medicament
Publikation
Pessler F.,
Chen F.,
Winterhoff M.,
Büssow K.,
Blankenfeldt W.,
Hirsch A. K. H.,
Elgaher W
(2021)
Patent, WO2022223778, 2022
Patent, WO2022223778, 2022
Crystalline sponge affinity screening: A fast tool for soaking condition optimization without the need of X-ray diffraction analysis
Publikation
Rosenberger L,
Essen C,
Khutia A,
Kühn C,
Georgi K,
Hirsch A,
Hartmann R,
Badolo L
(2021)
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 164, 10.1016/j.ejps.2021.105884, 34161782
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 164, 10.1016/j.ejps.2021.105884, 34161782
Terpenoid Hydrazones as Biomembrane Penetration Enhancers: FT-IR Spectroscopy and Fluorescence Probe Studies
Publikation
Nesterkina M,
Smola S,
Rusakova N,
Kravchenko I
(2021)
Molecules (Basel, Switzerland), 27, 1, 10.3390/molecules27010206, 35011438
Molecules (Basel, Switzerland), 27, 1, 10.3390/molecules27010206, 35011438
Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization
Publikation
Della Volpe S,
Linciano P,
Listro R,
Tumminelli E,
Amadio M,
Bonomo I,
Elgaher W,
Adam S,
Hirsch A,
Boeckler F,
Vasile F,
Rossi D,
Collina S
(2021)
Bioorganic chemistry, 116, 10.1016/j.bioorg.2021.105305, 34482166
Bioorganic chemistry, 116, 10.1016/j.bioorg.2021.105305, 34482166
Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier
Publikation
Abdallah M,
Hamed M,
Frakolaki E,
Katsamakas S,
Vassilaki N,
Bartenschlager R,
Zoidis G,
Hirsch A,
Abdel-Halim M,
Abadi A
(2021)
European journal of medicinal chemistry, 10.1016/j.ejmech.2021.114034
European journal of medicinal chemistry, 10.1016/j.ejmech.2021.114034
7-Hydroxycoumarins are Affinity-based Fluorescent Probes for Competitive Binding Studies of Macrophage Migration Inhibitory Factor
Publikation
Xiao Z,
Chen D,
Song S,
van der Vlag R,
van der Wouden P,
van Merkerk R,
Cool R,
Hirsch A,
Melgert B,
Quax W,
Poelarends G,
Dekker F
(2020)
Journal of medicinal chemistry, 10.1021/acs.jmedchem.0c01160, 32940040
Journal of medicinal chemistry, 10.1021/acs.jmedchem.0c01160, 32940040
Restriction-Free Construction of a Phage-Presented Very Short Macrocyclic Peptide Library
Publikation
Jakob V,
Helmsing S,
Hust M,
Empting M
(2020)
Methods in molecular biology (Clifton, N.J.), 2070, 95-113, 10.1007/978-1-4939-9853-1_6, 31625092
Methods in molecular biology (Clifton, N.J.), 2070, 95-113, 10.1007/978-1-4939-9853-1_6, 31625092
Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics
Publikation
Grandclaudon C,
Birudukota N,
Elgaher W,
Jumde R,
Yahiaoui S,
Arisetti N,
Hennessen F,
Hüttel S,
Stadler M,
Herrmann J,
Miethke M,
Hartmann R,
Müller R,
Hirsch A,
Brönstrup M
(2020)
European journal of medicinal chemistry, 188, 10.1016/j.ejmech.2019.112005, 31911294
European journal of medicinal chemistry, 188, 10.1016/j.ejmech.2019.112005, 31911294
Novel PqsR Inverse Agonists
Publikation
Hamed M,
Ahmed S,
Empting. M.,
Schütz C,
Hartmann R,
Röhrig T,
Kany A,
Hirsch A
(2020)
Patent, EP20150119/WO2021136805A1
Patent, EP20150119/WO2021136805A1