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Synthesis and Pharmacological Properties of Novel Esters Based on Monoterpenoids and Glycine
Publikation
Nesterkina M,
Kravchenko I
(2017)
Pharmaceuticals (Basel, Switzerland), 10, 2, 10.3390/ph10020047, 28524111
Pharmaceuticals (Basel, Switzerland), 10, 2, 10.3390/ph10020047, 28524111
Semi-synthetic vNAR libraries screened against therapeutic antibodies primarily deliver anti-idiotypic binders
Publikation
Könning D,
Rhiel L,
Empting M,
Grzeschik J,
Sellmann C,
Schröter C,
Zielonka S,
Dickgießer S,
Pirzer T,
Yanakieva D,
Becker S,
Kolmar H
(2017)
Sci. Rep., 7, 1, 10.1038/s41598-017-10513-9, 28852148
Sci. Rep., 7, 1, 10.1038/s41598-017-10513-9, 28852148
Pentapeptide‐rich peptidoglycan at the Bacillus subtilis cell‐division site
Publikation
Morales Angeles D,
Liu Y,
Hartman A,
Borisova M,
Sousa Borges A,
Kok N,
Beilharz K,
veening j,
Mayer C,
Hirsch A,
Scheffers D
(2017)
Molecular microbiology, 104, 2, 319-333, 10.1111/mmi.13629
Molecular microbiology, 104, 2, 319-333, 10.1111/mmi.13629
Camelid and shark single domain antibodies: structural features and therapeutic potential
Publikation
Könning D,
Zielonka S,
Grzeschik J,
Empting M,
Valldorf B,
Krah S,
Schröter C,
Sellmann C,
Hock B,
Kolmar H
(2017)
Current opinion in structural biology, 45, 10-16, 10.1016/j.sbi.2016.10.019, 27865111
Current opinion in structural biology, 45, 10-16, 10.1016/j.sbi.2016.10.019, 27865111
Designed Spiroketal Protein Modulation
Publikation
Scheepstra M,
Andrei S,
Unver M,
Hirsch A,
Leysen S,
Ottmann C,
Brunsveld L,
Milroy L
(2017)
Angewandte Chemie (International ed. in English), 56, 20, 5480-5484, 10.1002/anie.201612504, 28407400
Angewandte Chemie (International ed. in English), 56, 20, 5480-5484, 10.1002/anie.201612504, 28407400
Design and synthesis of thiamine analogues to study their binding to the ECF transporter for thiamine in bacteria
Publikation
Monjas L,
Swier L,
Voogd A,
Oudshoorn R,
Hirsch A,
Slotboom D
(2016)
Med. Chem. Commun., 7, 5, 966-971, 10.1039/C6MD00022C
Med. Chem. Commun., 7, 5, 966-971, 10.1039/C6MD00022C
Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds
Publikation
Zender M,
Witzgall F,
Drees S,
Weidel E,
Maurer C,
Fetzner S,
Blankenfeldt W,
Empting M,
Hartmann R
(2016)
ACS chemical biology, 10.1021/acschembio.6b00156, 27082157
ACS chemical biology, 10.1021/acschembio.6b00156, 27082157
Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors
Publikation
Elgaher W,
Sharma K,
Haupenthal J,
Saladini F,
Pires M,
Real E,
Mely Y,
Hartmann R
(2016)
Journal of medicinal chemistry, 10.1021/acs.jmedchem.6b00730, 27339173
Journal of medicinal chemistry, 10.1021/acs.jmedchem.6b00730, 27339173
Structure-Activity Relationships of 2-Sufonylpyrimidines as Quorum-Sensing Inhibitors to Tackle Biofilm Formation and eDNA Release of Pseudomonas aeruginosa
Publikation
Thomann A,
Brengel C,
Börger C,
Kail D,
Steinbach A,
Empting M,
Hartmann R
(2016)
ChemMedChem, 11, 22, 2522-2533, 10.1002/cmdc.201600419, 27731921
ChemMedChem, 11, 22, 2522-2533, 10.1002/cmdc.201600419, 27731921
Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site
Publikation
Masini T,
Birkaya B,
van Dijk S,
Mondal M,
Hekelaar J,
Jäger M,
van Terwisscha Scheltinga A,
Patel M,
Hirsch A,
Moman E
(2016)
Journal of enzyme inhibition and medicinal chemistry, 31, sup4, 170-175, 10.1080/14756366.2016.1201812, 27435185
Journal of enzyme inhibition and medicinal chemistry, 31, sup4, 170-175, 10.1080/14756366.2016.1201812, 27435185