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Dynamic combinatorial chemistry: a tool to facilitate the identification of inhibitors for protein targets
Publikation
Mondal M,
Hirsch A
(2015)
Chemical Society reviews, 44, 8, 2455-88, 10.1039/c4cs00493k, 25706945
Chemical Society reviews, 44, 8, 2455-88, 10.1039/c4cs00493k, 25706945
De novo fragment-based design of inhibitors of DXS guided by spin-diffusion-based NMR spectroscopy
Publikation
Masini T,
Pilger J,
Kroezen B,
Illarionov B,
Lottmann P,
Fischer M,
Griesinger C,
Hirsch A
(2014)
Chem. Sci., 5, 9, 3543-3551, 10.1039/C4SC00588K
Chem. Sci., 5, 9, 3543-3551, 10.1039/C4SC00588K
Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design
Publikation
Axer A,
Jumde R,
Adam S,
Faust A,
Schäfers M,
Fobker M,
Koehnke J,
Hirsch A,
Gilmour R
(2021)
Chem. Sci., 12, 4, 1286-1294, 10.1039/D0SC04297H
Chem. Sci., 12, 4, 1286-1294, 10.1039/D0SC04297H
N-Phenyl-3-Mercaptopropanamide Derivatives as Metallo-Beta-Lactamase Inhibitors for the Treatment of Bacterial Infections
Publikation
Hartmann R,
Konstantinovic J,
Haupenthal J,
Hirsch A,
Kany A,
Kaya C,
Yahiaoui S,
Wichelhaus T,
Proschak E
(2021)
Patent, A61K31/5375; A61P31/04; C07C233/15; C07C233/25; C07C233/33; C07C233/43; C07C233/54; C07C319/02; C07C323/52; C07D295/22;, WO2021191219A1
Patent, A61K31/5375; A61P31/04; C07C233/15; C07C233/25; C07C233/33; C07C233/43; C07C233/54; C07C319/02; C07C323/52; C07D295/22;, WO2021191219A1
Novel PqsR Inverse Agonists
Publikation
Hamed M,
Ahmed S,
Empting. M.,
Schütz C,
Hartmann R,
Röhrig T,
Kany A,
Hirsch A
(2021)
Patent, A61K31/4439; A61P31/04; C07D401/14; C07D417/14;, WO2021136805A1
Patent, A61K31/4439; A61P31/04; C07D401/14; C07D417/14;, WO2021136805A1
N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa
Publikation
Yahiaoui S,
Voos K,
Haupenthal J,
Wichelhaus T,
Frank D,
Weizel L,
Rotter M,
Brunst S,
Kramer J,
Proschak E,
Ducho C,
Hirsch A
(2021)
RSC Med. Chem., 10.1039/D1MD00187F
RSC Med. Chem., 10.1039/D1MD00187F
Hit-optimization using target-directed dynamic combinatorial chemistry: Development of inhibitors of the anti-infective target 1-deoxy-D-xylulose-5-phosphate synthase
Publikation
Jumde R,
Guadigni M,
Gierse R,
Alhayek A,
Di Zhu,
Hamid Z,
Johannsen S,
Elgaher W,
Neusens P,
Nehls C,
Haupenthal J,
Reiling N,
Hirsch A
(2021)
Chemical Science, 10.1039/D1SC00330E
Chemical Science, 10.1039/D1SC00330E
Citatronic Acid and Derivates thereof for use as a medicament
Publikation
Pessler F.,
Chen F.,
Winterhoff M.,
Büssow K.,
Blankenfeldt W.,
Hirsch A. K. H.,
Elgaher W
(2021)
Patent, WO2022223778, 2022
Patent, WO2022223778, 2022
Crystalline sponge affinity screening: A fast tool for soaking condition optimization without the need of X-ray diffraction analysis
Publikation
Rosenberger L,
Essen C,
Khutia A,
Kühn C,
Georgi K,
Hirsch A,
Hartmann R,
Badolo L
(2021)
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 164, 10.1016/j.ejps.2021.105884, 34161782
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 164, 10.1016/j.ejps.2021.105884, 34161782
Terpenoid Hydrazones as Biomembrane Penetration Enhancers: FT-IR Spectroscopy and Fluorescence Probe Studies
Publikation
Nesterkina M,
Smola S,
Rusakova N,
Kravchenko I
(2021)
Molecules (Basel, Switzerland), 27, 1, 10.3390/molecules27010206, 35011438
Molecules (Basel, Switzerland), 27, 1, 10.3390/molecules27010206, 35011438