Suche
Exploring the Role of Pseudomonas aeruginosa Elastase in Lung Epithelial Barrier Dysfunction: Advancing toward Antivirulence Therapies
Publikation
Shafiei R,
Alhayek A,
Hiller L,
Latta L,
Neu T,
Aljohmani A,
Abdollahibiroun S,
Schönborn E,
Yildiz D,
Schneider-Daum N,
Lehr C,
Haupenthal J,
Hirsch A
(2026)
ACS Infect. Dis., 10.1021/acsinfecdis.5c00915, 41960628
ACS Infect. Dis., 10.1021/acsinfecdis.5c00915, 41960628
Direct monitoring of intracellular polymer degradation via BODIPY dynamic dequenching
Publikation
Bassil J,
Kamal M,
Gabelmann A,
Christoulaki A,
Koch M,
Hamed M,
Loretz B,
Gallei M,
Buhler E,
Lehr C,
Hirsch A,
Lee S
(2025)
Mater. Des., 256, 10.1016/j.matdes.2025.114240
Mater. Des., 256, 10.1016/j.matdes.2025.114240
Toward Anti-Herpesviral PROTACs: Assessing the Challenges for Targeted Protein Degradation on the Example of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen
Publikation
Berwanger A,
Stein S,
Brandner S,
Kany A,
Heinz S,
Loretz B,
Lehr C,
Hirsch A,
Lermyte F,
Schulz T,
Empting* M
(2025)
ChemMedChem, 10.1002/cmdc.202500758, 41252598
ChemMedChem, 10.1002/cmdc.202500758, 41252598
Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape
Publikation
Lee S,
Nasr S,
Rasheed S,
Liu Y,
Hartwig O,
Kaya C,
Boese A,
Koch M,
Herrmann J,
Müller R,
Loretz B,
Buhler E,
Hirsch A,
Lehr C
(2022)
Journal of controlled release : official journal of the Controlled Release Society, 353, 915-929, 10.1016/j.jconrel.2022.12.018, 36521693
Journal of controlled release : official journal of the Controlled Release Society, 353, 915-929, 10.1016/j.jconrel.2022.12.018, 36521693
An Outer Membrane Vesicle-Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability
Publikation
Richter R,
Kamal M,
Koch M,
Niebuur B,
Huber A,
Goes A,
Volz C,
Vergalli J,
Kraus T,
Müller R,
Schneider-Daum N,
Fuhrmann G,
Pagès J,
Lehr C
(2022)
Advanced healthcare materials, 11, 5, 10.1002/adhm.202101180, 34614289
Advanced healthcare materials, 11, 5, 10.1002/adhm.202101180, 34614289
Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections
Publikation
Ho D,
Murgia X,
Rossi C,
Christmann R,
Hüfner de Mello Martins A,
Koch M,
Andreas A,
Herrmann J,
Müller R,
Empting M,
Hartmann R,
Desmaele D,
Loretz B,
Couvreur P,
Lehr C
(2020)
Angewandte Chemie (International ed. in English), 10.1002/anie.202001407, 32243047
Angewandte Chemie (International ed. in English), 10.1002/anie.202001407, 32243047
Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies
Publikation
Della Volpe S,
Nasti R,
Queirolo M,
Unver M,
Jumde V,
Dömling A,
Vasile F,
Potenza D,
Ambrosio F,
Costa G,
Alcaro S,
Zucal C,
Provenzani A,
Di Giacomo M,
Rossi D,
Hirsch A,
Collina S
(2019)
ACS Med. Chem. Lett., 10, 4, 615-620, 10.1021/acsmedchemlett.8b00600, 30996806
ACS Med. Chem. Lett., 10, 4, 615-620, 10.1021/acsmedchemlett.8b00600, 30996806
Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity
Publikation
Abdelsamie A,
Hamed M,
Schütz C,
Röhrig T,
Kany A,
Schmelz S,
Blankenfeldt W,
Hirsch A,
Hartmann R,
Empting M
(2024)
Eur. J. Med. Chem., 276, 10.1016/j.ejmech.2024.116685, 39042991
Eur. J. Med. Chem., 276, 10.1016/j.ejmech.2024.116685, 39042991
Identification of a new protein-RNA interaction inhibitor targeting the KH34 region of the insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2/IMP2)
Publikation
Berwanger A,
Wagner K,
Both S,
Kany A,
Mazlom K,
Hirsch A,
Kiemer A,
Empting M
(2026)
Eur. J. Med. Chem., 307, 10.1016/j.ejmech.2026.118624, 41687271
Eur. J. Med. Chem., 307, 10.1016/j.ejmech.2026.118624, 41687271
Tracheal tuft cell-released leukotrienes promote antibacterial immune responses
Publikation
Elhawy M,
Wadood N,
Grammer M,
Betzold P,
Herrmann E,
Lanzilli G,
Biradli F,
Klozenbücher C,
Klein A,
Alakkam N,
Hollenhorst M,
Gaini-Rahimi K,
Evers S,
Kusumakshi S,
Wyatt A,
Kany A,
Becker S,
Bischoff M,
Flockerzi V,
Gudermann T,
Chubanov V,
Empting M,
Hirsch A,
Schneider C,
Boehm U,
Krasteva-Christ G
(2026)
Cell Reports, 45, 9, 10.1016/j.celrep.2026.117863, 42632019
Cell Reports, 45, 9, 10.1016/j.celrep.2026.117863, 42632019