EN | DE
 info(at)helmholtz-hips.de
 Directions to Google
EN | DE
[Translate to Deutsch:]

Suche

Gesucht nach "drug". Zeige Ergebnisse 441 bis 450 von 717.

Application of Dual Inhibition Concept within Looped Autoregulatory Systems toward Antivirulence Agents against Pseudomonas aeruginosa Infections

Publikation
Thomann A, Mello Martins A, Brengel C, Empting M, Hartmann R (2016)
ACS chemical biology, 11, 5, 1279-86, 10.1021/acschembio.6b00117, 26882081

Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies

Publikation
Della Volpe S, Nasti R, Queirolo M, Unver M, Jumde V, Dömling A, Vasile F, Potenza D, Ambrosio F, Costa G, Alcaro S, Zucal C, Provenzani A, Di Giacomo M, Rossi D, Hirsch A, Collina S (2019)
ACS Med. Chem. Lett., 10, 4, 615-620, 10.1021/acsmedchemlett.8b00600, 30996806

Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity

Publikation
Abdelsamie A, Hamed M, Schütz C, Röhrig T, Kany A, Schmelz S, Blankenfeldt W, Hirsch A, Hartmann R, Empting M (2024)
Eur. J. Med. Chem., 276, 10.1016/j.ejmech.2024.116685, 39042991

Identification of a new protein-RNA interaction inhibitor targeting the KH34 region of the insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2/IMP2)

Publikation
Berwanger A, Wagner K, Both S, Kany A, Mazlom K, Hirsch A, Kiemer A, Empting M (2026)
Eur. J. Med. Chem., 307, 10.1016/j.ejmech.2026.118624, 41687271

Toward Anti-Herpesviral PROTACs: Assessing the Challenges for Targeted Protein Degradation on the Example of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen

Publikation
Berwanger A, Stein S, Brandner S, Kany A, Heinz S, Loretz B, Lehr C, Hirsch A, Lermyte F, Schulz T, Empting* M (2025)
ChemMedChem, 10.1002/cmdc.202500758, 41252598

Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosa

Publikation
Sahner J, Empting M, Kamal A, Weidel E, Groh M, Börger C, Hartmann R (2015)
European journal of medicinal chemistry, 96, 14-21, 10.1016/j.ejmech.2015.04.007, 25874327

From in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa

Publikation
Storz M, Allegretta G, Kirsch B, Empting M, Hartmann R (2014)
Organic & biomolecular chemistry, 12, 32, 6094-104, 10.1039/c4ob00707g, 24909330

The One-Step Synthesis of Biologically Active Isochromans from Lignin-Derived Aromatic Monomers in Tunable Deep Eutectic Solvents

Publikation
Kottayi A, Afanasenko A, Castillo-Garcia A, Elgaher W, Haupenthal J, Hirsch A, Barta K (2025)
Chem. Eur. J., 10.1002/chem.202502769, 41351205

Dynamic Proteoids Generated From Dipeptide-Based Monomers

Publikation
Liu Y, Stuart M, Buhler E, Hirsch A (2018)
Macromolecular rapid communications, 39, 13, 10.1002/marc.201800099, 29806088

Phage Display on the Anti-infective Target 1-Deoxy-d-xylulose-5-phosphate Synthase Leads to an Acceptor-Substrate Competitive Peptidic Inhibitor

Publikation
Marcozzi A, Masini T, Di Zhu, Pesce D, Illarionov B, Fischer M, Herrmann A, Hirsch A (2018)
ChemBioChem, 19, 1, 58-65, 10.1002/cbic.201700402, 29119720