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Identification of a new protein-RNA interaction inhibitor targeting the KH34 region of the insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2/IMP2)
Publikation
Berwanger A,
Wagner K,
Both S,
Kany A,
Mazlom K,
Hirsch A,
Kiemer A,
Empting M
(2026)
European journal of medicinal chemistry, 307, 10.1016/j.ejmech.2026.118624, 41687271
European journal of medicinal chemistry, 307, 10.1016/j.ejmech.2026.118624, 41687271
Toward Anti-Herpesviral PROTACs: Assessing the Challenges for Targeted Protein Degradation on the Example of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen
Publikation
Berwanger A,
Stein S,
Brandner S,
Kany A,
Heinz S,
Loretz B,
Lehr C,
Hirsch A,
Lermyte F,
Schulz T,
Empting* M
(2025)
ChemMedChem, 10.1002/cmdc.202500758, 41252598
ChemMedChem, 10.1002/cmdc.202500758, 41252598
Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity
Publikation
Abdelsamie A,
Hamed M,
Schütz C,
Röhrig T,
Kany A,
Schmelz S,
Blankenfeldt W,
Hirsch A,
Hartmann R,
Empting M
(2024)
Eur. J. Med. Chem., 276, 10.1016/j.ejmech.2024.116685, 39042991
Eur. J. Med. Chem., 276, 10.1016/j.ejmech.2024.116685, 39042991
Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosa
Publikation
Sahner J,
Empting M,
Kamal A,
Weidel E,
Groh M,
Börger C,
Hartmann R
(2015)
European journal of medicinal chemistry, 96, 14-21, 10.1016/j.ejmech.2015.04.007, 25874327
European journal of medicinal chemistry, 96, 14-21, 10.1016/j.ejmech.2015.04.007, 25874327
From in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa
Publikation
Storz M,
Allegretta G,
Kirsch B,
Empting M,
Hartmann R
(2014)
Organic & biomolecular chemistry, 12, 32, 6094-104, 10.1039/c4ob00707g, 24909330
Organic & biomolecular chemistry, 12, 32, 6094-104, 10.1039/c4ob00707g, 24909330
The One-Step Synthesis of Biologically Active Isochromans from Lignin-Derived Aromatic Monomers in Tunable Deep Eutectic Solvents
Publikation
Kottayi A,
Afanasenko A,
Castillo-Garcia A,
Elgaher W,
Haupenthal J,
Hirsch A,
Barta K
(2025)
Chem. Eur. J., 10.1002/chem.202502769, 41351205
Chem. Eur. J., 10.1002/chem.202502769, 41351205
Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement
Publikation
Zielinska A,
Savietto A,
Sousa Borges A,
Martinez D,
Berbon M,
Roelofsen J,
Hartman A,
Boer R,
van der Klei I,
Hirsch A,
Habenstein B,
Bramkamp M,
Scheffers D
(2020)
eLife, 9, 10.7554/eLife.57179
eLife, 9, 10.7554/eLife.57179
Synthesis and Evaluation on Anticonvulsant and Antidepressant Activities of Naphthoquinone Derivatives Containing Pyrazole and Pyrimidine Fragments
Publikation
Polish N,
Nesterkina M,
Marintsova N,
Karkhut A,
Kravchenko I,
Novikov V,
Khairulin A
(2020)
ACSi, 67, 3, 934-939, 10.17344/acsi.2020.5938
ACSi, 67, 3, 934-939, 10.17344/acsi.2020.5938
Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling
Publikation
Hollenhorst M,
Jurastow I,
Nandigama R,
Appenzeller S,
Li L,
Vogel J,
Wiederhold S,
Althaus M,
Empting M,
Altmüller J,
Hirsch A,
Flockerzi V,
Canning B,
Saliba A,
Krasteva-Christ G
(2020)
FASEB j., 34, 1, 316-332, 10.1096/fj.201901314RR
FASEB j., 34, 1, 316-332, 10.1096/fj.201901314RR
(2S,5R)-2-Isopropyl-5-methylcyclohexanone Hydrazones
Publikation
Nesterkina M,
Barbalat D,
Zheltvay I,
Rakipov I,
Atakay M,
Salih B,
Kravchenko I
(2019)
Molbank, 2019, 2, 10.3390/M1062
Molbank, 2019, 2, 10.3390/M1062