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The bacterial cell envelope as delimiter of anti-infective bioavailability – An in vitro permeation model of the Gram-negative bacterial inner membrane
Publikation
Graef F,
Vukosavljevic B,
Michel J,
Wirth M,
Ries O,
De Rossi C,
Windbergs M,
Rosilio V,
Ducho C,
Gordon S,
Lehr C
(2016)
Journal of Controlled Release, 243, 214-224, 10.1016/j.jconrel.2016.10.018
Journal of Controlled Release, 243, 214-224, 10.1016/j.jconrel.2016.10.018
Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus
Publikation
Kirch J,
Schneider A,
Abou B,
Hopf A,
Schaefer U,
Schneider M,
Schall C,
Wagner C,
Lehr C
(2012)
Proceedings of the National Academy of Sciences of the United States of America, 109, 45, 18355-18360, 10.1073/pnas.1214066109
Proceedings of the National Academy of Sciences of the United States of America, 109, 45, 18355-18360, 10.1073/pnas.1214066109
A three-dimensional coculture of enterocytes, monocytes and dendritic cells to model inflamed intestinal mucosa in vitro
Publikation
Leonard F,
Collnot E,
Lehr C
(2010)
Molecular pharmaceutics, 7, 6, 2103-2119, 10.1021/mp1000795
Molecular pharmaceutics, 7, 6, 2103-2119, 10.1021/mp1000795
A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms
Publikation
Schütz C,
Ho D,
Hamed M,
Abdelsamie A,
Röhrig T,
Herr C,
Kany A,
Rox K,
Schmelz S,
Siebenbürger L,
Wirth M,
Börger C,
Yahiaoui S,
Bals R,
Scrima A,
Blankenfeldt W,
Horstmann J,
Christmann R,
Murgia X,
Koch M,
Berwanger A,
Loretz B,
Hirsch A,
Hartmann R,
Lehr C,
Empting M
(2021)
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8, 12, 10.1002/advs.202004369, 34165899
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8, 12, 10.1002/advs.202004369, 34165899
pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers
Publikation
Lee S,
Kaya C,
Jang H,
Koch M,
Loretz B,
Buhler E,
Lehr C,
Hirsch A
(2020)
Mater. Chem. Front., 4, 3, 905-909, 10.1039/C9QM00651F
Mater. Chem. Front., 4, 3, 905-909, 10.1039/C9QM00651F
Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection
Publikation
Murgia X,
Kany A,
Herr C,
Ho D,
Rossi C,
Bals R,
Lehr C,
Hirsch A,
Hartmann R,
Empting M,
Röhrig T
(2020)
Scientific Reports, 10, 1, 10.1038/s41598-020-73459-5, 33020513
Scientific Reports, 10, 1, 10.1038/s41598-020-73459-5, 33020513
Transferring Microclusters of P. aeruginosa Biofilms to the Air-Liquid Interface of Bronchial Epithelial Cells for Repeated Deposition of Aerosolized Tobramycin
Publikation
Horstmann J,
Laric A,
Boese A,
Yildiz D,
Röhrig T,
Empting M,
Frank N,
Krug D,
Müller R,
Schneider-Daum N,
Souza Carvalho-Wodarz C,
Lehr C
(2022)
ACS infectious diseases, 8, 1, 137-149, 10.1021/acsinfecdis.1c00444, 34919390
ACS infectious diseases, 8, 1, 137-149, 10.1021/acsinfecdis.1c00444, 34919390
A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria
Publikation
Richter R,
Kamal M,
García-Rivera M,
Kaspar J,
Junk M,
Elgaher W,
Srikakulam S,
Gress A,
Beckmann A,
Grißmer A,
Meier C,
Vielhaber M,
Kalinina O,
Hirsch A,
Hartmann R,
Brönstrup M,
Schneider-Daum N,
Lehr C
(2020)
Materials today. Bio, 8, 10.1016/j.mtbio.2020.100084, 33313504
Materials today. Bio, 8, 10.1016/j.mtbio.2020.100084, 33313504
Starch-Chitosan Polyplexes
Publikation
Yasar H,
Ho D,
Rossi C,
Herrmann J,
Gordon S,
Loretz B,
Lehr C
(2018)
Polymers, 10, 3, 10.3390/polym10030252
Polymers, 10, 3, 10.3390/polym10030252
Towards Standardized Dissolution Techniques for In Vitro Performance Testing of Dry Powder Inhalers
Publikation
Floroiu A,
Klein M,
Krämer J,
Lehr C
(2018)
Dissolution Technologies, 25, 3, 6-18, 10.14227/DT250318P6
Dissolution Technologies, 25, 3, 6-18, 10.14227/DT250318P6