Dr. Jennifer Herrmann
Über
2025
A Chemo-Enzymatic Platform for Furanolide Synthesis and Functional Exploration
Ji X, Einsiedler M, D'Agostino P, Herrmann J, Müller R, Gulder T (2025)
ChemRxivDOI: 10.26434/chemrxiv-2025-90mp4
Natural products chlorotonils exert a complex antibacterial mechanism and address multiple targets
Deschner F, Mostert D, Daniel J, Voltz A, Schneider D, Khangholi N, Bartel J, Pessanha de Carvalho L, Brauer M, Gorelik T, …, Müller R, Herrmann J (2025)
Cell Chem. Biol.DOI: 10.1016/j.chembiol.2025.03.005
ClpP2 proteasomes and SpxA1 determine Listeria monocytogenes tartrolon B hyper-resistance
Engelgeh T, Wamp S, Rothe P, Herrmann J, Fischer M, Müller R, Halbedel S (2025)
PLOS Genetics 21 (4)DOI: 10.1371/journal.pgen.1011621
Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance
Rasheed S, Umstätter F, Mühlberg E, Beijer B, Hertlein T, Klika K, Kleist C, Werner J, Domhan C, Bingel M, …, Mier W, Uhl P (2025)
Adv. Therap.DOI: 10.1002/adtp.202400473
2024
Cystobactamid off-target profiling reveals favorable safety, superoxide reduction, and SCARB1 inhibition in eukaryotes
Risch T, Hellwinkel B, Mostert D, Kany A, Solga D, Seedorf T, Heimann D, Hoppstädter J, Kohnhäuser D, Hilgers J, …, Herrmann J, Müller R (2024)
BookDOI: 10.1101/2024.10.10.617689
Synthetic studies on the tetrasubstituted D-ring of cystobactamids lead to potent terephthalic acid antibiotics
Stappert M, Kohnhäuser D, Seedorf T, Coetzee J, Rox K, Fuchs H, Cirnski K, Leitner C, Herrmann J, Kirschning A, Müller R, Brönstrup M (2024)
Commun Chem 7 (1)DOI: 10.1038/s42004-024-01337-6
In Vivo Activity Profiling of Biosynthetic Darobactin D22 against Critical Gram-Negative Pathogens
Kany A, Fries F, Seyfert C, Porten C, Deckarm S, Chacón Ortiz M, Dubarry N, Vaddi S, Große M, Bernecker S, …, Herrmann J, Müller R (2024)
ACS Infect. Dis. 10 (12): 4337-4346DOI: 10.1021/acsinfecdis.4c00687
Autologous DNA mobilization and multiplication expedite natural products discovery from bacteria
Xie F, Zhao H, Liu J, Yang X, Neuber M, Agrawal A, Kaur A, Herrmann J, Kalinina O, Wei X, Müller R, Fu C (2024)
Science 386 (6727)DOI: 10.1126/science.abq7333
Interaction of the Atypical Tetracyclines Chelocardin and Amidochelocardin with Renal Drug Transporters
Rox K, Kühne A, Herrmann J, Jansen R, Hüttel S, Bernecker S, Hagos Y, Brönstrup M, Stadler M, Hesterkamp T, Müller R (2024)
ACS Pharmacol. Transl. Sci. 7 (7): 2093-2109DOI: 10.1021/acsptsci.4c00183
Optimization of the Central α-Amino Acid in Cystobactamids to the Broad-Spectrum, Resistance-Breaking Antibiotic CN-CC-861
Kohnhäuser D, Seedorf T, Cirnski K, Heimann D, Coetzee J, Sordello S, Richter J, Stappert M, Sabuco J, Corbett D, …, Kirschning A, Brönstrup M (2024)
J. Med. Chem.DOI: 10.1021/acs.jmedchem.4c00927&ref=pdf
Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application
Hofer W, Deschner F, Jézéquel G, Pessanha de Carvalho L, Abdel-Wadood N, Pätzold L, Bernecker S, Morgenstern B, Kany A, Große M, …, Herrmann J, Müller R (2024)
Angewandte Chemie (International ed. in English) 63 (19)DOI: 10.1002/anie.202319765
Identification by Synthesis: Imidacins, Urocanate-Derived Alkaloids from the Myxobacterium Stigmatella aurantiaca
Kostka M, Krug D, Herrmann J, Dickschat J, Meyer J, Müller R, Schulz S (2024)
Org. Lett.DOI: 10.1021/acs.orglett.4c02036
Point mutations in the ygiV promoter region lead to cystobactamid resistance and reduced virulence in E. coli
Müller R, Risch T, Kolling D, Mostert D, Seedorf T, Heimann D, Kohnhäuser D, Deschner F, Fries F, Solga D, …, Herrmann J, Sieber S (2024)
BookDOI: 10.21203/rs.3.rs-3751821/v1
The Peptide Antibiotic Corramycin Adopts a β-Hairpin-like Structure and Is Inactivated by the Kinase ComG
Adam S, Fries F, Tesmar A, Rasheed S, Deckarm S, Sousa C, Reberšek R, Risch T, Mancini S, Herrmann J, …, Kalinina O, Müller R (2024)
J. Am. Chem. Soc.DOI: 10.1021/jacs.3c13208
Inhibitory effect of sorangicin A against mutant DNA-dependent RNA polymerase in the obligate intracellular bacterium Chlamydia trachomatis
Li Q, Jansen H, Hansen G, Nurjadi D, Herrmann J, Stadler M, Brönstrup M, Müller R, He C, Graspeuntner S, Rupp J, Shima K (2024)
Int. J. Antimicrob. AgentsDOI: 10.1016/j.ijantimicag.2024.107132
Nitroxoline resistance is associated with significant fitness loss and diminishes in vivo virulence of Escherichia coli
Deschner F, Risch T, Baier C, Schlüter D, Herrmann J, Müller R (2024)
Microbiology Spectrum 12 (1)DOI: 10.1128/spectrum.03079-23
Is Simultaneous Binding to DNA and Gyrase Important for the Antibacterial Activity of Cystobactamids?
Solga D, Wieske L, Wilcox S, Zeilinger C, Jansen-Olliges L, Cirnski K, Herrmann J, Müller R, Erdelyi M, Kirschning A (2024)
Chem. Eur. J.DOI: 10.1002/chem.202303796
Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents
Khalifa H, Rasheed S, Haupenthal J, Herrmann J, Mandour Y, Abadi A, Engel M, Müller R, Hirsch A, Abdel-Halim* M, Hamed* M (2024)
Archiv der PharmazieDOI: 10.1002/ardp.202300656
2023
New Genetically Engineered Derivatives of Antibacterial Darobactins Underpin Their Potential for Antibiotic Development
Seyfert C, Müller A, Walsh D, Birkelbach J, Kany A, Porten C, Yuan B, Krug D, Herrmann J, Marlovits T, Hirsch A, Müller R (2023)
J. Med. Chem.DOI: 10.1021/acs.jmedchem.3c01660
Discovery and overproduction of novel highly bioactive pamamycins through transcriptional engineering of the biosynthetic gene cluster
Eckert N, Rebets Y, Horbal L, Zapp J, Herrmann J, Busche T, Müller R, Kalinowski J, Luzhetskyy A (2023)
Microb. Cell Fact. 22 (1)DOI: 10.1186/s12934-023-02231-x
Tartrolon sensing and detoxification by the Listeria monocytogenes timABR resistance operon
Engelgeh T, Herrmann J, Jansen R, Müller R, Halbedel S (2023)
BookDOI: 10.1101/2023.07.27.550809
New Genetically Engineered Derivatives of Antibacterial Darobac-tins Underpin their Potential for Antibiotic Development
Seyfert C, Müller A, Walsh D, Birkelbach J, Kany A, Porten C, Yuan B, Krug D, Herrmann J, Marlovits T, Hirsch A, Müller R (2023)
BookDOI: 10.26434/chemrxiv-2023-24tmj
Impact of Drug Administration Routes on the In Vivo Efficacy of the Natural Product Sorangicin a Using a Staphylococcus aureus Infection Model in Zebrafish Embryos
Fries F, Kany A, Rasheed S, Hirsch A, Müller R, Herrmann J (2023)
International journal of molecular sciences 24 (16)DOI: 10.3390/ijms241612791
Optimization of Mass Spectrometry Imaging for Drug Metabolism and Distribution Studies in the Zebrafish Larvae Model: A Case Study with the Opioid Antagonist Naloxone
Park Y, Meyer M, Müller R, Herrmann J (2023)
International journal of molecular sciences 24 (12)DOI: 10.3390/ijms241210076
In Vitro Activity of Two Novel Antimicrobial Compounds on MDR-Resistant Clinical Isolates
Rima M, Pfennigwerth N, Cremanns M, Cirnski K, Oueslati S, Gatermann S, d’Amélio N, Herrmann J, Müller R, Naas T (2023)
Antibiotics 12 (8)DOI: 10.3390/antibiotics12081265
The mycobacterial ImuA'-ImuB-DnaE2 mutasome: composition and recruitment in live cells
Gessner S, Martin Z, Reiche M, Santos J, Dinkele R, Ramudzuli A, Dhar N, Wet T, Anoosheh S, Lang D, …, Lamers M, Warner D (2023)
eLife 12DOI: 10.7554/eLife.75628
Quantification of Plasmodium falciparum HRP-2 as an alternative method to 3Hhypoxanthine incorporation to measure the parasite reduction ratio in vitro
Carvalho L, Niepoth E, Mavraj-Husejni A, Kreidenweiss A, Herrmann J, Müller R, Knaab T, Burckhardt B, Kurz T, Held J (2023)
Int. J. Antimicrob. Agents 62 (3)DOI: 10.1016/j.ijantimicag.2023.106894
The Disorazole Z Family of Highly Potent Anticancer Natural Products from Sorangium cellulosum: Structure, Bioactivity, Biosynthesis, and Heterologous Expression
Gao Y, Birkelbach J, Fu C, Herrmann J, Irschik H, Morgenstern B, Hirschfelder K, Li R, Zhang Y, Jansen R, Müller R (2023)
Microbiology SpectrumDOI: 10.1128/spectrum.00730-23
Evaluation of extraction methods for untargeted metabolomic studies for future applications in zebrafish larvae infection models
Schippers P, Rasheed S, Park Y, Risch T, Wagmann L, Hemmer S, Manier S, Müller R, Herrmann J, Meyer M (2023)
Sci. Rep. 13 (1)DOI: 10.1038/s41598-023-34593-y
Sorangicin A Is Active against Chlamydia in Cell Culture, Explanted Fallopian Tubes, and Topical In Vivo Treatment
Graspeuntner S, Koethke K, Scholz C, Semmler L, Lupatsii M, Kirchhoff L, Herrmann J, Rox K, Wittstein K, Käding N, …, Shima K, Rupp J (2023)
Antibiotics 12 (5)DOI: 10.3390/antibiotics12050795
The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection
Bublitz A, Brauer M, Wagner S, Hofer W, Müsken M, Deschner F, Lesker T, Neumann-Schaal M, Paul L, Nübel U, …, Fuchs T, Strowig T (2023)
Cell Host MicrobeDOI: 10.1016/j.chom.2023.04.003
The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition
Koller T, Scheid U, Kösel T, Herrmann J, Krug D, Boshoff H, Beckert B, Evans J, Schlemmer J, Sloan B, …, Wilson D, Müller R (2023)
J. Am. Chem. Soc. 145 (2): 851-863DOI: 10.1021/jacs.2c08816
2022
Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape
Lee S, Nasr S, Rasheed S, Liu Y, Hartwig O, Kaya C, Boese A, Koch M, Herrmann J, Müller R, …, Hirsch A, Lehr C (2022)
Journal of controlled release : official journal of the Controlled Release Society 353: 915-929DOI: 10.1016/j.jconrel.2022.12.018
Darobactins Exhibiting Superior Antibiotic Activity by Cryo-EM Structure Guided Biosynthetic Engineering
Seyfert C, Porten C, Yuan B, Deckarm S, Panter F, Bader C, Coetzee J, Deschner F, Tehrani K, Higgins P, …, Herrmann J, Müller R (2022)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202214094
Interference with lipoprotein maturation sensitizes methicillin-resistant Staphylococcus aureus to human group IIA secreted phospholipase A 2 and daptomycin
Kuijk M, Wu Y, van Hensbergen V, Shanlitourk G, Payré C, Lambeau G, Herrmann J, Müller R, van Strijp J, Pannekoek Y, Touqui L, van Sorge N (2022)
BookDOI: 10.1101/2022.02.06.476181
Natural products lysobactin and sorangicin A show in vitro activity against Mycobacterium abscessus complex
Sullivan J, Yao J, Courtine C, Lupien A, Herrmann J, Müller R, Behr M (2022)
BookDOI: 10.1101/2022.06.27.497873
Regio- and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives
Müller R, Hofer W, Oueis E, Abou Fayad A, Deschner F, Andreas A, Carvalho L, Hüttel S, Bernecker S, Pätzold L, …, Held J, Herrmann J (2022)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202202816
Induction of Liver Size Reduction in Zebrafish Larvae by the Emerging Synthetic Cannabinoid 4F-MDMB-BINACA and Its Impact on Drug Metabolism
Park Y, Dahlem C, Meyer M, Kiemer A, Müller R, Herrmann J (2022)
Molecules (Basel, Switzerland) 27 (4)DOI: 10.3390/molecules27041290
Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part
Megahed S, Rasheed S, Herrmann J, El-Hossary E, El-Shabrawy Y, Abadi A, Engel M, Müller R, Abdel-Halim M, Hamed M (2022)
Bioorg Med Chem Lett 59DOI: 10.1016/j.bmcl.2022.128531
2021
Towards the sustainable discovery and development of new antibiotics
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo P, Glaser P, Aigle B, Bode H, …, Moser H, Müller R (2021)
Nature reviews. Chemistry 5 (10): 726-749DOI: 10.1038/s41570-021-00313-1
Expanding the Myxochelin Natural Product Family by Nicotinic Acid Containing Congeners
Frank N, Széles M, Akone S, Rasheed S, Hüttel S, Frewert S, Hamed M, Herrmann J, Schuler S, Hirsch A, Müller R (2021)
Molecules 26 (16)DOI: 10.3390/molecules26164929
Improved broad-spectrum antibiotics against Gram-negative pathogens via darobactin biosynthetic pathway engineering
Groß S, Panter F, Pogorevc D, Seyfert C, Deckarm S, Bader C, Herrmann J, Müller R (2021)
Chem. Sci. 12 (35): 11882-11893DOI: 10.1039/d1sc02725e
Zebrafish: An Attractive Model to Study Staphylococcus aureus Infection and Its Use as a Drug Discovery Tool
Rasheed S, Fries F, Müller R, Herrmann J (2021)
Pharmaceuticals 14 (6)DOI: 10.3390/ph14060594
2020
Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics
Grandclaudon C, Birudukota N, Elgaher W, Jumde R, Yahiaoui S, Arisetti N, Hennessen F, Hüttel S, Stadler M, Herrmann J, …, Hirsch A, Brönstrup M (2020)
European journal of medicinal chemistry 188DOI: 10.1016/j.ejmech.2019.112005
Synthetic and Biological Studies on New Urea and Triazole Containing Cystobactamid Derivatives
Planke T, Cirnski K, Herrmann J, Müller R, Kirschning A (2020)
Chem. Eur. J. 26 (19): 4289-4296DOI: 10.1002/chem.201904073
The glucocorticoid-induced leucine zipper mediates statin-induced muscle damage
Hoppstädter J, Valbuena Perez J, Linnenberger R, Dahlem C, Legroux T, Hecksteden A, Tse W, Flamini S, Andreas A, Herrmann J, …, Bruscoli S, Kiemer A (2020)
FASEB j. 34 (3): 4684-4701DOI: 10.1096/fj.201902557RRR
Toxicokinetics and toxicodynamics of the fentanyl homologs cyclopropanoyl-1-benzyl-4´-fluoro-4-anilinopiperidine and furanoyl-1-benzyl-4-anilinopiperidine
Gampfer T, Wagmann L, Park Y, Cannaert A, Herrmann J, Fischmann S, Westphal F, Müller R, Stove C, Meyer M (2020)
Arch. Toxicol. 94 (6): 2009-2025DOI: 10.1007/s00204-020-02726-1
Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics
Elgaher W, Hamed M, Baumann S, Herrmann J, Siebenbürger L, Krull J, Cirnski K, Kirschning A, Brönstrup M, Müller R, Hartmann R (2020)
Chem. Eur. J. 26 (32): 7219-7225DOI: 10.1002/chem.202000117
Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin
Hennessen F, Miethke M, Zaburannyi N, Loose M, Lukežic T, Bernecker S, Hüttel S, Jansen R, Schmiedel J, Fritzenwanker M, …, Herrmann J, Müller R (2020)
Antibiotics 9 (9)DOI: 10.3390/antibiotics9090619
How to Study the Metabolism of New Psychoactive Substances for the Purpose of Toxicological Screenings-A Follow-Up Study Comparing Pooled Human Liver S9, HepaRG Cells, and Zebrafish Larvae
Wagmann L, Frankenfeld F, Park Y, Herrmann J, Fischmann S, Westphal F, Müller R, Flockerzi V, Meyer M (2020)
Frontiers in chemistry 8DOI: 10.3389/fchem.2020.00539
The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase
Lilic M, Chen J, Boyaci H, Braffman N, Hubin E, Herrmann J, Müller R, Mooney R, Landick R, Darst S, Campbell E (2020)
Proc. Natl. Acad. Sci. U.S.A.DOI: 10.1073/pnas.2013706117
Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry
Cirnski K, Coetzee J, Herrmann J, Müller R (2020)
Journal of visualized experiments : JoVE (164)DOI: 10.3791/61703
Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model
Park Y, Meyer M, Müller R, Herrmann J (2020)
Molecules 25 (19)DOI: 10.3390/molecules25194474
PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus
Anversa Dimer F, Souza Carvalho-Wodarz C, Goes A, Cirnski K, Herrmann J, Schmitt V, Pätzold L, Abed N, Rossi C, Bischoff M, …, Müller R, Lehr C (2020)
Nanomedicine : nanotechnology, biology, and medicine 24DOI: 10.1016/j.nano.2019.102125
Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections
Ho D, Murgia X, Rossi C, Christmann R, Hüfner de Mello Martins A, Koch M, Andreas A, Herrmann J, Müller R, Empting M, …, Couvreur P, Lehr C (2020)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202001407
Protein‐Templated Hit Identification via an Ugi Four‐Component Reaction
Mancini F, Unver M, Elgaher W, Jumde V, Alhayek A, Lukat P, Herrmann J, Witte M, Köck M, Blankenfeldt W, Müller R, Hirsch A (2020)
Chem. Eur. J.DOI: 10.1002/chem.202002250
Synthesis and Biological Evaluation of Novel 2-Substituted Analogues of (–)-Pentenomycin I
Zisopoulou S, Bousis S, Haupenthal J, Herrmann J, Müller R, Hirsch A, Komiotis D, Gallos J, Stathakis C (2020)
Synlett 31 (05): 475-481DOI: 10.1055/s-0039-1690772
Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy
Testolin G, Cirnski K, Rox K, Prochnow H, Fetz V, Grandclaudon C, Mollner T, Baiyoumy A, Ritter A, Leitner C, …, Müller R, Brönstrup M (2020)
Chemical Science 11 (5): 1316-1334DOI: 10.1039/C9SC04769G
2019
Engineering Atypical Tetracycline Formation in Amycolatopsis sulphurea for the Production of Modified Chelocardin Antibiotics
Lukežic T, Fayad A, Bader C, Harmrolfs K, Bartuli J, Groß S, Lešnik U, Hennessen F, Herrmann J, Pikl Š, Petkovic H, Müller R (2019)
ACS Chem. Biol. 14 (3): 468-477DOI: 10.1021/acschembio.8b01125
2018
Starch-Chitosan Polyplexes
Yasar H, Ho D, Rossi C, Herrmann J, Gordon S, Loretz B, Lehr C (2018)
Polymers 10 (3)DOI: 10.3390/polym10030252
Activation of the NLRP3 inflammasome by hyaboron, a new asymmetric boron-containing macrodiolide from the Myxobacterium Hyalangium minutum
Surup F, Chauhan D, Niggemann J, Bartok E, Herrmann J, Koeck M, Zander W, Stadler M, Hornung V, Müller R (2018)
ACS Chem. Biol. 13 (10): 2981-2988DOI: 10.1021/acschembio.8b00659
Octapeptins: lipopeptide antibiotics against multidrug-resistant superbugs
Abou Fayad A, Herrmann J, Müller R (2018)
Cell Chem. Biol. 25 (4): 351-353DOI: 10.1016/j.chembiol.2018.04.003
Biosynthesis of the Klebsiella oxytoca Pathogenicity Factor Tilivalline: Heterologous Expression, in Vitro Biosynthesis, and Inhibitor Development
Tesmar A, Hoffmann M, Abou Fayad A, Hüttel S, Schmitt V, Herrmann J, Müller R (2018)
ACS Chem. Biol. 13 (3): 812-819DOI: 10.1021/acschembio.7b00990
2017
Discovery and Total Synthesis of Natural Cystobactamid Derivatives with Superior Activity against Gram-Negative Pathogens
Hüttel S, Testolin G, Herrmann J, Planke T, Gille F, Moreno M, Stadler M, Brönstrup M, Kirschning A, Müller R (2017)
Angewandte Chemie (International ed. in English) 56 (41): 12760-12764DOI: 10.1002/anie.201705913
Novel and revisited approaches in antituberculosis drug discovery
Herrmann J, Rybniker J, Müller R (2017)
Current opinion in biotechnology 48: 94-101DOI: 10.1016/j.copbio.2017.03.023
Thioholgamides: Thioamide-Containing Cytotoxic RiPP Natural Products
Kjaerulff L, Sikandar A, Zaburannyi N, Adam S, Herrmann J, Koehnke J, Müller R (2017)
ACS Chem. Biol. 12 (11): 2837-2841DOI: 10.1021/acschembio.7b00676
Pyxipyrrolones: Structure elucidation and biosynthesis of cytotoxic myxobacterial metabolites
Kjaerulff L, Raju R, Panter F, Scheid U, Garcia R, Herrmann J, Müller R (2017)
Angew. Chem. Int. Ed. 56 (32): 9614-9618DOI: 10.1002/anie.201704790
The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
Fu C, Sikandar A, Donner J, Zaburannyi N, Herrmann J, Reck M, Wagner-Döbler I, Koehnke J, Müller R (2017)
Nat Commun 8 (1)DOI: 10.1038/s41467-017-01671-5
Structure and biosynthesis of crocagins: polycyclic postranslationally modified ribosomal peptides from Chondromyces crocatus
Viehrig K, Surup F, Volz C, Herrmann J, Abou Fayad A, Adam S, Kohnke J, Trauner D, Müller R (2017)
Angew. Chem. (56): 1-5DOI: 10.1002/anie.201612640
Natural products from myxobacteria: novel metabolites and bioactivities
Herrmann J, Fayad A, Müller R (2017)
Nat. Prod. Rep. 34 (2): 135-160DOI: 10.1039/C6NP00106H
2016
Strategies for the discovery and development of new antibiotics from natural products: Three case studies
Herrmann J, Lukezic T, Kling A, Baumann S, Hüttel S, Petkovic H, Müller R (2016)
Contribution: 1-25DOI: 10.1007/82_2016_498
Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies
Maurer C, Fruth M, Empting M, Avrutina O, Hossmann J, Nadmid S, Gorges J, Herrmann J, Kazmaier U, Dersch P, Muller R, Hartmann R (2016)
Future medicinal chemistry 8 (9): 931-47DOI: 10.4155/fmc-2016-0033
Isolation, structure elucidation, and (bio)synthesis of Haprolid, a cell-type-specific myxobacterial cytotoxin
Steinmetz H, Li J, Fu C, Zaburannyi N, Kunze B, Harmrolfs K, Schmitt V, Herrmann J, Reichenbach H, Hofle G, Kalesse M, Müller R (2016)
Angew. Chem. Int. Ed. Engl. 55 (34): 10113-7DOI: 10.1002/anie.201603288
Room temperature electrocompetent bacterial cells improve DNA transformation and recombineering efficiency
Tu Q, Yin J, Fu J, Herrmann J, Li Y, Yin Y, Stewart A, Müller R, Zhang Y (2016)
Sci. Rep. 6DOI: 10.1038/srep24648
Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering
Tu Q, Herrmann J, Hu S, Raju R, Bian X, Zhang Y, Müller R (2016)
Sci. Rep. 6DOI: 10.1038/srep21066
2015
Squalenoylation of Chitosan: A Platform for Drug Delivery?
Lepeltier E, Loretz B, Desmaele D, Zapp J, Herrmann J, Couvreur P, Lehr C (2015)
Biomacromolecules 16 (9): 2930-9DOI: 10.1021/acs.biomac.5b00840
Biosynthetic studies of telomycin reveal new lipopeptides with enhanced activity
Fu C, Keller L, Bauer A, Brönstrup M, Froidbise A, Hammann P, Herrmann J, Mondesert G, Kurz M, Schiell M, …, Wink J, Müller R (2015)
J. Am. Chem. Soc. 137 (24): 7692-7705DOI: 10.1021/jacs.5b01794
Targeting DnaN for tuberculosis therapy using novel griselimycins
Kling A, Lukat P, Almeida D, Bauer A, Fontaine E, Sordello S, Zaburannyi N, Herrmann J, Wenzel S, König C, …, Lagrange S, Müller R (2015)
Science 348 (6239): 1106-1112DOI: 10.1126/science.aaa4690
Synthesis and biological evaluation of cystobactamid 507: a bacterial topoisomerase inhibitor from Cystobacter sp
Moreno M, Elgaher W, Herrmann J, Schläger N, Hamed M, Baumann S, Müller R, Hartmann R, Kirschning A (2015)
Synlett 26 (9): 1175-1178DOI: 10.1055/s-0034-1380509
Cystodienoic acid: A new diterpene isolated from the myxobacterium Cystobacter sp.
Raju R, Mohr K, Bernecker S, Herrmann J, Müller R (2015)
J. Antibiot. 68: 473-475DOI: 10.1038/ja.2015.8
Heterologous expression of an orphan NRPS gene cluster from Paenibacillus larvae in Escherichia coli revealed production of sevadicin
Tang Y, Frewert S, Harmrolfs K, Herrmann J, Karmann L, Kazmaier U, Xia L, Zhang Y, Müller R (2015)
J. Biotechnol. 194: 112-114DOI: 10.1016/j.jbiotec.2014.12.008
2014
Cystobactamids: myxobacterial topoisomerase inhibitors exhibiting potent antibacterial activity
Baumann S, Herrmann J, Raju R, Steinmetz H, Mohr K, Hüttel S, Harmrolfs K, Stadler M, Müller R (2014)
Angew. Chem. Int. Ed. 53 (52): 14605-14609DOI: 10.1002/anie.201409964
Disciformycins A and B: 12-membered macrolide glycoside antibiotics from the myxobacterium Pyxidicoccus fallax active against multiresistant staphylococci
Surup F, Viehrig K, Mohr K, Herrmann J, Jansen R, Müller R (2014)
Angew. Chem. Int. Ed. Engl. 49 (53): 13588-13591DOI: 10.1002/anie.201406973
Cystobactamid und Derivate als Antibiotika
Baumann S, Herrmann J, Mohr K, Steinmetz H, Gerth K, Raju R, Müller R (2014)
Patent (1451)
2013
Discovery and biological activity of new chondramides from Chondromyces sp.
Herrmann J, Hüttel S, Müller R (2013)
ChemBioChem 14 (13): 1573-1580DOI: 10.1002/cbic.201300140
Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues
Li X, Herrmann J, Zang Y, Grellier P, Prado S, Müller R, Nay B (2013)
Beilstein J. Org. Chem. 9: 1551-1558DOI: 10.3762/bjoc.9.176
In vivo evidence for a prodrug activation mechanism during colibactin maturation
Bian X, Fu J, Plaza A, Herrmann J, Pistorius D, Stewart A, Zhang Y, Müller R (2013)
ChemBioChem 14 (10): 1194-1197DOI: 10.1002/cbic.201300208
Activity-guided screening of bioactive natural compounds implementing a new glucocorticoid-receptor-translocation assay and detection of new anti-inflammatory steroids from bacteria
Kaufmann K, Simmons L, Herrmann J, Schwär G, Luniak N, Müller R (2013)
Biotechnol. Lett. 35 (1): 11-20DOI: 10.1007/s10529-012-1042-0
2012
The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles
Ruge C, Schaefer U, Herrmann J, Kirch J, Cañadas O, Echaide M, Pérez-Gil J, Casals C, Müller R, Lehr C (2012)
PLoS ONE 7 (7)DOI: 10.1371/journal.pone.0040775
Rubimycinone A, a new anthraquinone from a terrestrial Streptomyces sp.
Raju R, Gromyko O, Fedorenko V, Herrmann J, Luzhetskyy A, Müller R (2012)
Tetrahedron Lett. 54 (8): 900-902DOI: 10.1016/j.tetlet.2012.11.130
Pretubulysin: From hypothetical biosynthetic intermediate to potential lead in tumor therapy
Herrmann J, Elnakady Y, Wiedmann R, Ullrich A, Rohde M, Kazmaier U, Vollmar A, Müller R (2012)
PLoS ONE 7 (5)DOI: 10.1371/journal.pone.0037416
2011
Mining the cinnabaramide biosynthetic pathway to generate novel proteasome inhibitors
Rachid S, Huo L, Herrmann J, Stadler M, Köpcke B, Bitzer J, Müller R (2011)
ChemBioChem 12 (6): 922-931DOI: 10.1002/cbic.201100024
2009
Pretubulysin, a potent and chemically accessible tubulysin precursor from Angiococcus disciformis
Ullrich A, Chai Y, Pistorius D, Elnakady Y, Herrmann J, Weissman K, Kazmaier U, Müller R (2009)
Angew. Chem. Int. Ed. Engl. 48 (24): 4422-4425DOI: 10.1002/anie.200900406
Synthesis and Biological Evaluation of Pretubulysin and Derivatives
Ullrich A, Herrmann J, Müller R, Kazmaier U (2009)
Eur. J. Org. Chem. 2009 (36): 6367-6378