The problem of antimicrobial resistance (AMR) is growing and endangers our health systems. In particular, multi-resistant Gram-negative bacteria such as E. coli are classified by the WHO as critical pathogens. In their search for effective compounds to combat antibiotic-resistant bacteria, researchers from the Department of Microbial Natural Products have discovered the natural product Corramycin, which is effective against even different strains of E. coli. In this video, Selina explains more about the project, which was published in the journal Angewandte Chemie.
New natural product against hospital germs
Corramycin is a new compound with activity against Gram-negative pathogens
The natural product Corramycin was isolated from the myxobacterium Corallococcus coralloides. In this paper, Rolf Müller's team describes the biosynthetic gene cluster and presents a biosynthesis model. In addition to the production of larger quantities of Corramycin, the team also describes a total synthesis approach with the help of which the absolute configuration of the active compound could be elucidated. Corramycin is active against the Gram-negative bacterium E. coli and has so far shown no toxicity - a promising starting position for further development into an antibiotic for human medicine.
Couturier, C, Groß, S., von Tesmar, A., Hoffmann, J., Deckarm, S., Fievet, A., Dubarry, N., Taillier, T., Pöverlein, C., Stump, H., Kurz, M., Toti, L., Haag Richter, S., Schummer, D., Sizun, P., Hoffmann, M., Awal, R.P., Zaburannyi, N., Harmrolfs, K., Wink, J., Lessoud, E., Vermat, T., Cazals, V., Silve, S., Bauer, A., Mourez, M., Fraisse, L., Leroi-Geissler, C., Rey, A., Versluys, S., Bacqué, E., Müller, R. and Renard, R. (2022) Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin, Angew. Chem. Int. Ed., 10.1002/anie.202210747
Graphic for the natural product Corramycin © HIPS