Dirk Hauck
Über
Dirk Hauck absolvierte eine Ausbildung zum Chemielaboranten bei Merck in Darmstadt und machte ein Vordiplom in Chemie an der Universität Frankfurt. Seit Februar 2011 arbeitet er als technischer Assistent bei der Titz-Gruppe.
Er führt organische Synthesen durch und analysiert deren Produkte, unterstützt die Arbeiten von Gruppenmitgliedern, organisiert den praktischen laufenden Betrieb im Labor und betreut das Equipment.
2023
The resuscitation-promoting factor (Rpf) from Micrococcus luteus and its putative reaction product 1,6-anhydro-MurNAc increase culturability of environmental bacteria
Guzman J, Raval D, Hauck D, Titz A, Poehlein A, Degenkolb T, Daniel R, Vilcinskas A (2023)
Access microbiology 5 (9)DOI: 10.1099/acmi.0.000647.v4
Pseudomonas aeruginosa LecB suppresses immune responses by inhibiting transendothelial migration
Sponsel J, Guo Y, Hamzam L, Lavanant A, Pérez-Riverón A, Partiot E, Muller Q, Rottura J, Gaudin R, Hauck D, …, Römer W, Mueller C (2023)
EMBO reports 24 (4)DOI: 10.15252/embr.202255971
Neutralizing the Impact of the Virulence Factor LecA from Pseudomonas aeruginosa on Human Cells with New Glycomimetic Inhibitors
Zahorska E, Rosato F, Stober K, Kuhaudomlarp S, Meiers J, Hauck D, Reith D, Gillon E, Rox K, Imberty A, Römer W, Titz A (2023)
Angewandte Chemie (International ed. in English) 62 (7)DOI: 10.1002/anie.202215535
2021
A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN
Wawrzinek R, Wamhoff E, Lefebre J, Rentzsch M, Bachem G, Domeniconi G, Schulze J, Fuchsberger F, Zhang H, Modenutti C, …, Ernst B, Rademacher C (2021)
J. Am. Chem. Soc. 143 (45): 18977-18988DOI: 10.1021/jacs.1c07235
2020
Directing Drugs to Bugs: Antibiotic-Carbohydrate Conjugates Targeting Biofilm-Associated Lectins of Pseudomonas aeruginosa
Meiers J, Zahorska E, Röhrig T, Hauck D, Wagner S, Titz A (2020)
Journal of medicinal chemistry 63 (20): 11707-11724DOI: 10.1021/acs.jmedchem.0c00856
2019
Anti-biofilm Agents against Pseudomonas aeruginosa: A Structure-Activity Relationship Study of C-Glycosidic LecB Inhibitors
Sommer R, Rox K, Wagner S, Hauck D, Henrikus S, Newsad S, Arnold T, Ryckmans T, Brönstrup M, Imberty A, …, Hartmann R, Titz A (2019)
Journal of medicinal chemistry 62 (20): 9201-9216DOI: 10.1021/acs.jmedchem.9b01120
2018
Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa
Sommer R, Wagner S, Rox K, Varrot A, Hauck D, Wamhoff E, Schreiber J, Ryckmans T, Brunner T, Rademacher C, …, Imberty A, Titz A (2018)
Journal of the American Chemical Society 140 (7): 2537-2545DOI: 10.1021/jacs.7b11133
2017
Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging
Wagner S, Hauck D, Hoffmann M, Sommer R, Joachim I, Müller R, Imberty A, Varrot A, Titz A (2017)
Angewandte Chemie (International ed. in English) 56 (52): 16559-16564DOI: 10.1002/anie.201709368
Photorhabdus luminescens lectin A (PllA): A new probe for detecting α-galactoside-terminating glycoconjugates
Beshr G, Sikandar A, Jemiller E, Klymiuk N, Hauck D, Wagner S, Wolf E, Koehnke J, Titz A (2017)
J Biol Chem 292 (48): 19935-19951DOI: 10.1074/jbc.M117.812792
Efficient Two Step β-Glycoside Synthesis from N-Acetyl d-Glucosamine: Scope and Limitations of Copper(II) Triflate-Catalyzed Glycosylation
Sommer R, Hauck D, Titz A (2017)
ChemistrySelect 2 (15)DOI: 10.1002/slct.201700161
2016
Development of a competitive binding assay for the Burkholderia cenocepacia lectin BC2L-A and structure activity relationship of natural and synthetic inhibitors
Beshr G, Sommer R, Hauck D, Siebert D, Hofmann A, Imberty A, Titz A (2016)
Med Chem Commun 7 (3): 519-530DOI: 10.1039/C5MD00557D
Development and optimization of a competitive binding assay for the galactophilic low affinity lectin LecA from Pseudomonas aeruginosa
Joachim I, Rikker S, Hauck D, Ponader D, Boden S, Sommer R, Hartmann L, Titz A (2016)
Org. Biomol. Chem. 14 (33): 7933-48DOI: 10.1039/c6ob01313a
O-Alkylated heavy atom carbohydrate probes for protein X-ray crystallography: Studies towards the synthesis of methyl 2-O-methyl-L-selenofucopyranoside
Sommer R, Hauck D, Varrot A, Imberty A, Künzler M, Titz A (2016)
Beilstein journal of organic chemistry 12: 2828-2833DOI: 10.3762/bjoc.12.282
2015
Cinnamide Derivatives of d-Mannose as Inhibitors of the Bacterial Virulence Factor LecB from Pseudomonas aeruginosa
Sommer R, Hauck D, Varrot A, Wagner S, Audfray A, Prestel A, Möller H, Imberty A, Titz A (2015)
ChemistryOpen 4 (6): 756-67DOI: 10.1002/open.201500162
Synthesis of mannoheptose derivatives and their evaluation as inhibitors of the lectin LecB from the opportunistic pathogen Pseudomonas aeruginosa
Hofmann A, Sommer R, Hauck D, Stifel J, Göttker-Schnetmann I, Titz A (2015)
Carbohydrate research 412: 34-42DOI: 10.1016/j.carres.2015.04.010
2014
Methylated glycans as conserved targets of animal and fungal innate defense
Wohlschlager T, Butschi A, Grassi P, Sutov G, Gauss R, Hauck D, Schmieder S, Knobel M, Titz A, Dell A, …, Aebi M, Künzler M (2014)
Proceedings of the National Academy of Sciences of the United States of America 111 (27): 2787-96DOI: 10.1073/pnas.1401176111
2013
Discovery of two classes of potent glycomimetic inhibitors of Pseudomonas aeruginosa LecB with distinct binding modes
Hauck D, Joachim I, Frommeyer B, Varrot A, Philipp B, Möller H, Imberty A, Exner T, Titz A (2013)
ACS chemical biology 8 (8): 1775-84DOI: 10.1021/cb400371r