Researcher in Laboratory © HIPS

Dirk Hauck


Dirk Hauck made an apprenticeship as Chemielaborant at Merck in Darmstadt and received a Vordiplom in Chemistry from the University of Frankfurt. Since February 2011 he is in the Titz group as lab technician. 
He is mainly involved in chemical synthesis and analysis, support of lab members, and organizes the lab routine and maintenance of the equipment.


The resuscitation-promoting factor (Rpf) from Micrococcus luteus and its putative reaction product 1,6-anhydro-MurNAc increase culturability of environmental bacteria

Guzman J, Raval D, Hauck D, Titz A, Poehlein A, Degenkolb T, Daniel R, Vilcinskas A (2023)

Access microbiology 5 (9)DOI: 10.1099/acmi.0.000647.v4

Pseudomonas aeruginosa LecB suppresses immune responses by inhibiting transendothelial migration

Sponsel J, Guo Y, Hamzam L, Lavanant A, Pérez-Riverón A, Partiot E, Muller Q, Rottura J, Gaudin R, Hauck D, …, Römer W, Mueller C (2023)

EMBO reports 24 (4)DOI: 10.15252/embr.202255971

Neutralizing the Impact of the Virulence Factor LecA from Pseudomonas aeruginosa on Human Cells with New Glycomimetic Inhibitors

Zahorska E, Rosato F, Stober K, Kuhaudomlarp S, Meiers J, Hauck D, Reith D, Gillon E, Rox K, Imberty A, Römer W, Titz A (2023)

Angewandte Chemie (International ed. in English) 62 (7)DOI: 10.1002/anie.202215535


A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN

Wawrzinek R, Wamhoff E, Lefebre J, Rentzsch M, Bachem G, Domeniconi G, Schulze J, Fuchsberger F, Zhang H, Modenutti C, …, Ernst B, Rademacher C (2021)

J. Am. Chem. Soc. 143 (45): 18977-18988DOI: 10.1021/jacs.1c07235


Directing Drugs to Bugs: Antibiotic-Carbohydrate Conjugates Targeting Biofilm-Associated Lectins of Pseudomonas aeruginosa

Meiers J, Zahorska E, Röhrig T, Hauck D, Wagner S, Titz A (2020)

Journal of medicinal chemistry 63 (20): 11707-11724DOI: 10.1021/acs.jmedchem.0c00856


Anti-biofilm Agents against Pseudomonas aeruginosa: A Structure-Activity Relationship Study of C-Glycosidic LecB Inhibitors

Sommer R, Rox K, Wagner S, Hauck D, Henrikus S, Newsad S, Arnold T, Ryckmans T, Brönstrup M, Imberty A, …, Hartmann R, Titz A (2019)

Journal of medicinal chemistry 62 (20): 9201-9216DOI: 10.1021/acs.jmedchem.9b01120


Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa

Sommer R, Wagner S, Rox K, Varrot A, Hauck D, Wamhoff E, Schreiber J, Ryckmans T, Brunner T, Rademacher C, …, Imberty A, Titz A (2018)

Journal of the American Chemical Society 140 (7): 2537-2545DOI: 10.1021/jacs.7b11133


Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging

Wagner S, Hauck D, Hoffmann M, Sommer R, Joachim I, Müller R, Imberty A, Varrot A, Titz A (2017)

Angewandte Chemie (International ed. in English) 56 (52): 16559-16564DOI: 10.1002/anie.201709368

Photorhabdus luminescens lectin A (PllA): A new probe for detecting α-galactoside-terminating glycoconjugates

Beshr G, Sikandar A, Jemiller E, Klymiuk N, Hauck D, Wagner S, Wolf E, Koehnke J, Titz A (2017)

J Biol Chem 292 (48): 19935-19951DOI: 10.1074/jbc.M117.812792

Efficient Two Step β-Glycoside Synthesis from N-Acetyl d-Glucosamine: Scope and Limitations of Copper(II) Triflate-Catalyzed Glycosylation

Sommer R, Hauck D, Titz A (2017)

ChemistrySelect 2 (15)DOI: 10.1002/slct.201700161


O-Alkylated heavy atom carbohydrate probes for protein X-ray crystallography: Studies towards the synthesis of methyl 2-O-methyl-L-selenofucopyranoside

Sommer R, Hauck D, Varrot A, Imberty A, Künzler M, Titz A (2016)

Beilstein journal of organic chemistry 12: 2828-2833DOI: 10.3762/bjoc.12.282

Development of a competitive binding assay for the Burkholderia cenocepacia lectin BC2L-A and structure activity relationship of natural and synthetic inhibitors

Beshr G, Sommer R, Hauck D, Siebert D, Hofmann A, Imberty A, Titz A (2016)

Med Chem Commun 7 (3): 519-530DOI: 10.1039/C5MD00557D

Development and optimization of a competitive binding assay for the galactophilic low affinity lectin LecA from Pseudomonas aeruginosa

Joachim I, Rikker S, Hauck D, Ponader D, Boden S, Sommer R, Hartmann L, Titz A (2016)

Org. Biomol. Chem. 14 (33): 7933-48DOI: 10.1039/c6ob01313a


Cinnamide Derivatives of d-Mannose as Inhibitors of the Bacterial Virulence Factor LecB from Pseudomonas aeruginosa

Sommer R, Hauck D, Varrot A, Wagner S, Audfray A, Prestel A, Möller H, Imberty A, Titz A (2015)

ChemistryOpen 4 (6): 756-67DOI: 10.1002/open.201500162

Synthesis of mannoheptose derivatives and their evaluation as inhibitors of the lectin LecB from the opportunistic pathogen Pseudomonas aeruginosa

Hofmann A, Sommer R, Hauck D, Stifel J, Göttker-Schnetmann I, Titz A (2015)

Carbohydrate research 412: 34-42DOI: 10.1016/j.carres.2015.04.010


Methylated glycans as conserved targets of animal and fungal innate defense

Wohlschlager T, Butschi A, Grassi P, Sutov G, Gauss R, Hauck D, Schmieder S, Knobel M, Titz A, Dell A, …, Aebi M, Künzler M (2014)

Proceedings of the National Academy of Sciences of the United States of America 111 (27): 2787-96DOI: 10.1073/pnas.1401176111


Discovery of two classes of potent glycomimetic inhibitors of Pseudomonas aeruginosa LecB with distinct binding modes

Hauck D, Joachim I, Frommeyer B, Varrot A, Philipp B, Möller H, Imberty A, Exner T, Titz A (2013)

ACS chemical biology 8 (8): 1775-84DOI: 10.1021/cb400371r