Researcher in Laboratory © HIPS

Dr Brigitta Loretz


Brigitta Loretz studied microbiology, did her diploma thesis at the Medical Chemistry and Biochemistry Department and her Ph.D. at the Pharmaceutical Technology Department, University of Innsbruck, Austria.
Her scientific interest is on carriers for intracellular delivery of biopharmaceutics, in particular, nucleotides, for the use in treatment/prevention of infectious diseases, and the development of new excipients, e.g. of new biodegradable polymers for this purpose. Her studies include delivery systems for antiinfectives, antigens or immune modulators as well as cell- or tissue-based models for the design/investigation of (nano)carrier-enabled delivery via non-invasive routes.


Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections

Konstantinovic J, Kany A, Alhayek A, Abdelsamie A, Sikandar A, Voos K, Yao Y, Andreas A, Shafiei R, Loretz B, …, Haupenthal J, Hirsch A (2023)

ACS Cent. Sci. 9 (12): 2205-2215DOI: 10.1021/acscentsci.3c01102

Disrupting Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latent Replication with a Small Molecule Inhibitor

Berwanger A, Stein S, Kany A, Gartner M, Loretz B, Lehr C, Hirsch A, Schulz T, Empting M (2023)

Journal of medicinal chemistry 66 (15): 10782-10790DOI: 10.1021/acs.jmedchem.3c00990

pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA

Liu Y, Ashmawy S, Latta L, Weiss A, Kiefer A, Nasr S, Loretz B, Hirsch A, Lee S, Lehr C (2023)

Biomacromolecules 24 (8): 3742-3754DOI: 10.1021/acs.biomac.3c00424

Inhibitors of the Elastase LasB for the treatment of Pseudomonas aeruginosa lung infections

Konstantinovic J, Kany A, Alhayek A, Abdelsamie A, Sikandar A, Voos K, Yao Y, Andreas A, Shafiei R, Loretz B, …, Haupenthal J, Hirsch A (2023)

DOI: 10.26434/chemrxiv-2023-bszcb


Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape

Lee S, Nasr S, Rasheed S, Liu Y, Hartwig O, Kaya C, Boese A, Koch M, Herrmann J, Müller R, …, Hirsch A, Lehr C (2022)

Journal of controlled release : official journal of the Controlled Release Society 353: 915-929DOI: 10.1016/j.jconrel.2022.12.018

Leaky gut model of the human intestinal mucosa for testing siRNA-based nanomedicine targeting JAK1

Hartwig O, Loretz B, Nougarede A, Jary D, Sulpice E, Gidrol X, Navarro F, Lehr C (2022)

J Control Release 345: 646-660DOI: 10.1016/j.jconrel.2022.03.037

Nano-in-Microparticles for Aerosol Delivery of Antibiotic-Loaded, Fucose-Derivatized, and Macrophage-Targeted Liposomes to Combat Mycobacterial Infections: In Vitro Deposition, Pulmonary Barrier Interactions, and Targeted Delivery

Huck B, Thiyagarajan D, Bali A, Boese A, Besecke K, Hozsa C, Gieseler R, Furch M, Carvalho-Wodarz C, Waldow F, …, Loretz B, Lehr C (2022)

Advanced healthcare materials 11 (11)DOI: 10.1002/adhm.202102117

Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: Composition, structure and barrier properties

Huck B, Murgia X, Frisch S, Hittinger M, Hidalgo A, Loretz B, Lehr C (2022)

Advanced Drug Delivery Reviews 183DOI: 10.1016/j.addr.2022.114141


Towards the sustainable discovery and development of new antibiotics

Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo P, Glaser P, Aigle B, Bode H, …, Moser H, Müller R (2021)

Nature reviews. Chemistry 5 (10): 726-749DOI: 10.1038/s41570-021-00313-1

Surfactant-Free Glibenclamide Nanoparticles: Formulation, Characterization and Evaluation of Interactions with Biological Barriers

Arrua E, Hartwig O, Ho D, Loretz B, Murgia X, Salomon C, Lehr C (2021)

Pharmaceutical research 38 (6): 1081-1092DOI: 10.1007/s11095-021-03056-2

Co-Delivery of mRNA and pDNA Using Thermally Stabilized Coacervate-Based Core-Shell Nanosystems

Nasr S, Lee S, Thiyagarajan D, Boese A, Loretz B, Lehr C (2021)

Pharmaceutics 13 (11)DOI: 10.3390/pharmaceutics13111924

A pulmonary mucus surrogate for investigating antibiotic permeation and activity against Pseudomonas aeruginosa biofilms

Frisch S, Boese A, Huck B, Horstmann J, Ho D, Schwarzkopf K, Murgia X, Loretz B, Souza Carvalho-Wodarz C, Lehr C (2021)

The Journal of antimicrobial chemotherapy 76 (6): 1472-1479DOI: 10.1093/jac/dkab068

Analysis and Optimization of Two Film-Coated Tablet Production Processes by Computer Simulation: A Case Study

Hering S, Schäuble N, Buck T, Loretz B, Rillmann T, Stieneker F, Lehr C (2021)

Processes 9 (1)DOI: 10.3390/pr9010067

Drug delivery for fighting infectious diseases: a global perspective

Loretz B, Oh Y, Hudson S, Gu Z, Lehr C (2021)

Drug delivery and translational research 11 (4): 1316-1322DOI: 10.1007/s13346-021-01009-1

Microbiota and cancer: In vitro and in vivo models to evaluate nanomedicines

Ladaycia A, Loretz B, Passirani C, Lehr C, Lepeltier E (2021)

Advanced Drug Delivery Reviews 170: 44-70DOI: 10.1016/j.addr.2020.12.015

A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms

Schütz C, Ho D, Hamed M, Abdelsamie A, Röhrig T, Herr C, Kany A, Rox K, Schmelz S, Siebenbürger L, …, Lehr C, Empting M (2021)

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8 (12)DOI: 10.1002/advs.202004369

Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals

Thiyagarajan D, Huck B, Nothdurft B, Koch M, Rudolph D, Rutschmann M, Feldmann C, Hozsa C, Furch M, Besecke K, …, Loretz B, Lehr C (2021)

Drug delivery and translational research 11 (4): 1766-1778DOI: 10.1007/s13346-021-01011-7


Synthesis and Biopharmaceutical Characterization of Amphiphilic Squalenyl Derivative Based Versatile Drug Delivery Platform

Ho D, Christmann R, Murgia X, Rossi C, Frisch S, Koch M, Schaefer U, Loretz B, Desmaele D, Couvreur P, Lehr C (2020)

Frontiers in chemistry 8DOI: 10.3389/fchem.2020.584242

Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases

Christmann R, Ho D, Wilzopolski J, Lee S, Koch M, Loretz B, Vogt T, Bäumer W, Schaefer U, Lehr C (2020)

Pharmaceutics 12 (12)DOI: 10.3390/pharmaceutics12121131

pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers

Lee S, Kaya C, Jang H, Koch M, Loretz B, Buhler E, Lehr C, Hirsch A (2020)

Mater. Chem. Front. 4 (3): 905-909DOI: 10.1039/C9QM00651F

Itaconic Acid Increases the Efficacy of Tobramycin against Pseudomonas aeruginosa Biofilms

Ho D, Rossi C, Loretz B, Murgia X, Lehr C (2020)

Pharmaceutics 12 (8)DOI: 10.3390/pharmaceutics12080691

Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections

Ho D, Murgia X, Rossi C, Christmann R, Hüfner de Mello Martins A, Koch M, Andreas A, Herrmann J, Müller R, Empting M, …, Couvreur P, Lehr C (2020)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202001407

Nanoparticle Targeting to Scalp Hair Follicles: New Perspectives for a Topical Therapy for Alopecia Areata

Christmann R, Thomas C, Jager N, Raber A, Loretz B, Schaefer U, Tschernig T, Vogt T, Lehr C (2020)

The Journal of investigative dermatology 140 (1): 243-246DOI: 10.1016/j.jid.2019.05.028


Macro- and Microrheological Properties of Mucus Surrogates in Comparison to Native Intestinal and Pulmonary Mucus

Huck B, Hartwig O, Biehl A, Schwarzkopf K, Wagner C, Loretz B, Murgia X, Lehr C (2019)

Biomacromolecules 20 (9): 3504-3512DOI: 10.1021/acs.biomac.9b00780

Challenges and Strategies in Drug Delivery Systems for Treatment of Pulmonary Infections

Ho D, Nichols B, Edgar K, Murgia X, Loretz B, Lehr C (2019)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.VDOI: 10.1016/j.ejpb.2019.09.002

Bioinspired Liposomes for Oral Delivery of Colistin to Combat Intracellular Infections by Salmonella enterica

Menina S, Eisenbeis J, Kamal M, Koch M, Bischoff M, Gordon S, Loretz B, Lehr C (2019)

Advanced healthcare materials 8 (17)DOI: 10.1002/adhm.201900564

Preferential uptake of chitosan-coated PLGA nanoparticles by primary human antigen presenting cells

Durán V, Yasar H, Becker J, Thiyagarajan D, Loretz B, Kalinke U, Lehr C (2019)

Nanomedicine : nanotechnology, biology, and medicine 21DOI: 10.1016/j.nano.2019.102073


Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles

Yasar H, Biehl A, Rossi C, Koch M, Murgia X, Loretz B, Lehr C (2018)

Journal of nanobiotechnology 16 (1)DOI: 10.1186/s12951-018-0401-y

Can lifecycle management safeguard innovation in the pharmaceutical industry?

Hering S, Loretz B, Friedli T, Lehr C, Stieneker F (2018)

Drug Discovery TodayDOI: 10.1016/j.drudis.2018.10.008

The role of mucus on drug transport and its potential to affect therapeutic outcomes

Murgia X, Loretz B, Hartwig O, Hittinger M, Lehr C (2018)

Advanced Drug Delivery Reviews 124: 82-97DOI: 10.1016/j.addr.2017.10.009

Oral delivery of macromolecular drugs

Savla R, Hartwig O, Lim Chin W, Loretz B, Lehr C (2018)

Pharm. Technol. Eur. 30 (7): 22-26

Farnesylated Glycol Chitosan as a Platform for Drug Delivery

Ho D, Frisch S, Biehl A, Terriac E, Rossi C, Schwarzkopf K, Lautenschläger F, Loretz B, Murgia X, Lehr C (2018)

Biomacromolecules 19 (8): 3489-3501DOI: 10.1021/acs.biomac.8b00795

Chemically modified h CFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis

Haque, A. K. M. Ashiqul, Dewerth A, Antony J, Riethmüller J, Schweizer G, Weinmann P, Latifi N, Yasar H, Pedemonte N, …, Handgretinger R, Kormann M (2018)

Scientific Reports 8 (1)DOI: 10.1038/s41598-018-34960-0

Polysaccharide Submicrocarrier for Improved Pulmonary Delivery of Poorly Soluble Anti-infective Ciprofloxacin

Ho D, Costa A, Rossi C, Souza Carvalho-Wodarz C, Loretz B, Lehr C (2018)

Molecular pharmaceutics 15 (3): 1081-1096DOI: 10.1021/acs.molpharmaceut.7b00967

A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes

Serr I, Scherm M, Zahm A, Schug J, Flynn V, Hippich M, Kälin S, Becker M, Achenbach P, Nikolaev A, …, Ziegler A, Daniel C (2018)

Science translational medicine 10 (422)DOI: 10.1126/scitranslmed.aag1782

Co-culture of human alveolar epithelial (hAELVi) and macrophage (THP-1) cell lines

Kletting S, Barthold S, Repnik U, Griffiths G, Loretz B, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2018)

ALTEX 35 (2): 211-222DOI: 10.14573/altex.1607191

Starch-Chitosan Polyplexes

Yasar H, Ho D, Rossi C, Herrmann J, Gordon S, Loretz B, Lehr C (2018)

Polymers 10 (3)DOI: 10.3390/polym10030252

Postmenopausaler Lichen planopilaris alias fibrosierende frontotemporale Alopezie Kossard

Vogt T, Thomas C, Reichrath J, Schilling L, Mawlood D, Christmann R, Loretz B, Schäfer U, Lehr C, Müller C (2018)

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 69 (2): 134-142DOI: 10.1007/s00105-017-4118-x


Permanent gene correction by means of nucleotide-modified messenger RNA

Kormann M, Lehr C, Loretz B, Malaeksefat E (2017)

Patent (DE/08.10.13/ DEA102013111099)

Modelling the bronchial barrier in pulmonary drug delivery

Murgia X, Yasar H, Carvalho-Wodarz C, Loretz B, Gordon S, Schwarzkopf K, Schaefer U, Lehr C (2017)

European Journal of Pharmaceutics and Biopharmaceutics 118: 79-88DOI: 10.1016/j.ejpb.2017.03.020

Biodegradable starch derivatives with tunable charge density-synthesis, characterization, and transfection efficiency

Thiele C, Loretz B, Lehr C (2017)

Drug delivery and translational research 7 (2): 252-258DOI: 10.1007/s13346-016-0333-8


Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities

Mostaghaci B, Loretz B, Lehr C (2016)

Current Pharmaceutical Design 22 (11): 1529-33

Self-Assembly and Shape Control of Hybrid Nanocarriers Based on Calcium Carbonate and Carbon Nanodots

Lauth V, Loretz B, Lehr C, Maas M, Rezwan K (2016)

Chemistry of Materials 28 (11): 3796-3803DOI: 10.1021/acs.chemmater.6b00769

Design of Polyamine-Grafted Starches for Nucleotide Analogue Delivery: In Vitro Evaluation of the Anticancer Activity

Kanber E, Yamada H, Loretz B, Lepeltier E, Lehr C (2016)

Bioconjugate chemistryDOI: 10.1021/acs.bioconjchem.6b00396

Autologous co-culture of primary human alveolar macrophages and epithelial cells for investigating aerosol medicines. Part II: evaluation of IL-10-loaded microparticles for the treatment of lung inflammation

Hittinger M, Mell N, Huwer H, Loretz B, Schneider-Daum N, Lehr C (2016)

Alternatives to laboratory animals : ATLA 44 (4): 349-360

miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity

Serr I, Furst R, Ott V, Scherm M, Nikolaev A, Gokmen F, Kalin S, Zillmer S, Bunk M, Weigmann B, …, Ziegler A, Daniel C (2016)

Proceedings of the National Academy of Sciences of the United States of America 113 (43): 6659-DOI: 10.1073/pnas.1606646113

Preparation of nanosized coacervates of positive and negative starch derivatives intended for pulmonary delivery of proteins

Barthold S, Kletting S, Taffner J, De Souza Carvalho-Wodarz C, Lepeltier E, Loretz B, Lehr C (2016)

Journal of Materials Chemistry B 4 (13): 2377-2386DOI: 10.1039/c6tb00178e


Overview of Inhaled Nanopharmaceuticals

Barthold S, Kunschke N, Murgia X, Loretz B, Carvalho Wodarz C, Lehr C (2015)


P-glycoprotein interactions of novel psychoactive substances - stimulation of ATP consumption and transport across Caco-2 monolayers

Meyer M, Wagmann L, Schneider-Daum N, Loretz B, Souza Carvalho C, Lehr C, Maurer H (2015)

Biochemical pharmacology 94 (3): 220-6DOI: 10.1016/j.bcp.2015.01.008

Enhanced uptake and siRNA-mediated knockdown of a biologically relevant gene using cyclodextrin polyrotaxane

Dandekar P, Jain R, Keil M, Loretz B, Koch M, Wenz G, Lehr C (2015)

Journal of Materials Chemistry B 3 (13): 2590-2598DOI: 10.1039/c4tb01821d

Transfection system of amino-functionalized calcium phosphate nanoparticles: in vitro efficacy, biodegradability, and immunogenicity study

Mostaghaci B, Susewind J, Kickelbick G, Lehr C, Loretz B (2015)

ACS applied materials & interfaces 7 (9): 5124-33DOI: 10.1021/am507193a

Cyclodextrin-based star polymers as a versatile platform for nanochemotherapeutics: Enhanced entrapment and uptake of idarubicin

Nafee N, Hirosue M, Loretz B, Wenz G, Lehr C (2015)

Colloids and surfaces. B, Biointerfaces 129: 30-8DOI: 10.1016/j.colsurfb.2015.03.014

Dimethylaminoethyl methacrylate copolymer-siRNA nanoparticles for silencing a therapeutically relevant gene in macrophages

Jain R, Dandekar P, Loretz B, Koch M, Lehr C (2015)

MedChemComm 6 (4): 691-701DOI: 10.1039/c4md00490f

Squalenoylation of Chitosan: A Platform for Drug Delivery?

Lepeltier E, Loretz B, Desmaele D, Zapp J, Herrmann J, Couvreur P, Lehr C (2015)

Biomacromolecules 16 (9): 2930-9DOI: 10.1021/acs.biomac.5b00840

In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency

Mahiny A, Dewerth A, Mays L, Alkhaled M, Mothes B, Malaeksefat E, Loretz B, Rottenberger J, Brosch D, Reautschnig P, …, Lehr C, Kormann M (2015)

Nature biotechnology 33 (6): 584-6DOI: 10.1038/nbt.3241


Design of starch-graft-PEI polymers: an effective and biodegradable gene delivery platform

Yamada H, Loretz B, Lehr C (2014)

Biomacromolecules 15 (5): 1753-61DOI: 10.1021/bm500128k

Polyester-idarubicin nanoparticles and a polymer-photosensitizer complex as potential drug formulations for cell-mediated drug delivery

Blaudszun A, Lian Q, Schnabel M, Loretz B, Steinfeld U, Lee H, Wenz G, Lehr C, Schneider M, Philippi A (2014)

International journal of pharmaceutics 474 (1-2): 70-9DOI: 10.1016/j.ijpharm.2014.07.048


Crossing biological barriers for advanced drug delivery

Schneider M, Windbergs M, Daum N, Loretz B, Collnot E, Hansen S, Schaefer U, Lehr C (2013)

European Journal of Pharmaceutics and Biopharmaceutics 84 (2): 239-241DOI: 10.1016/j.ejpb.2013.03.009

One-step synthesis of nanosized and stable amino-functionalized calcium phosphate particles for DNA transfection

Mostaghaci B, Loretz B, Haberkorn R, Kickelbick G, Lehr C (2013)

Chemistry of Materials 25 (18): 3667-3674DOI: 10.1021/cm401886u


Cellular delivery of polynucleotides by cationic cyclodextrin polyrotaxanes

Dandekar P, Jain R, Keil M, Loretz B, Muijs L, Schneider M, Auerbach D, Jung G, Lehr C, Wenz G (2012)

Journal of controlled release : official journal of the Controlled Release Society 164 (3): 387-93DOI: 10.1016/j.jconrel.2012.06.040

A hydrophobic starch polymer for nanoparticle-mediated delivery of docetaxel

Dandekar P, Jain R, Stauner T, Loretz B, Koch M, Wenz G, Lehr C (2012)

Macromolecular Bioscience 12 (2): 184-94DOI: 10.1002/mabi.201100244

Pulmonary delivery and tissue distribution of aerosolized antisense 2'-O-Methyl RNA containing nanoplexes in the isolated perfused and ventilated rat lung

Dong M, Murdter T, Philippi C, Loretz B, Schaefer U, Lehr C, Schwab M, Ammon-Treiber S (2012)

European Journal of Pharmaceutics and Biopharmaceutics 81 (3): 478-85DOI: 10.1016/j.ejpb.2012.04.022


Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2'-O-methyl-RNA

Dong M, Philippi C, Loretz B, Nafee N, Schaefer U, Friedel G, Ammon-Treiber S, Griese E, Lehr C, Klotz U, Murdter T (2011)

International journal of pharmaceutics 419 (1-2): 33-42DOI: 10.1016/j.ijpharm.2011.07.009

Enhanced cellular delivery of idarubicin by surface modification of propyl starch nanoparticles employing pteroic acid conjugated polyvinyl alcohol

Jain R, Dandekar P, Loretz B, Melero A, Stauner T, Wenz G, Koch M, Lehr C (2011)

International journal of pharmaceutics 420 (1): 147-55DOI: 10.1016/j.ijpharm.2011.08.030


Telomerase as an emerging target to fight cancer - Opportunities and challenges for nanomedicine

Philippi C, Loretz B, Schaefer U, Lehr C (2010)

Journal of Controlled Release 146 (2): 228-240DOI: 10.1016/j.jconrel.2010.03.025

Nanoparticles made from novel starch derivatives for transdermal drug delivery

Santander-Ortega M, Stauner T, Loretz B, Ortega-Vinuesa J, Bastos-Gonzalez D, Wenz G, Schaefer U, Lehr C (2010)

Journal of controlled release : official journal of the Controlled Release Society 141 (1): 85-92DOI: 10.1016/j.jconrel.2009.08.012