EN | DE

Dr Brigitta Loretz

About

Brigitta Loretz studied microbiology, did her diploma thesis at the Medical Chemistry and Biochemistry Department and her Ph.D. at the Pharmaceutical Technology Department, University of Innsbruck, Austria.
Her scientific interest is on carriers for intracellular delivery of biopharmaceutics, in particular, nucleotides, for the use in treatment/prevention of infectious diseases, and the development of new excipients, e.g. of new biodegradable polymers for this purpose. Her studies include delivery systems for antiinfectives, antigens or immune modulators as well as cell- or tissue-based models for the design/investigation of (nano)carrier-enabled delivery via non-invasive routes.


2021

Towards the sustainable discovery and development of new antibiotics

Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo P, Glaser P, Aigle B, Bode H, …, Moser H, Müller R (2021)

Nat Rev Chem: 1-24DOI: 10.1038/s41570-021-00313-1

Microbiota and cancer: In vitro and in vivo models to evaluate nanomedicines

Ladaycia A, Loretz B, Passirani C, Lehr C, Lepeltier E (2021)

Advanced Drug Delivery Reviews 170: 44-70DOI: 10.1016/j.addr.2020.12.015

Analysis and Optimization of Two Film-Coated Tablet Production Processes by Computer Simulation: A Case Study

Hering S, Schäuble N, Buck T, Loretz B, Rillmann T, Stieneker F, Lehr C (2021)

Processes 9 (1)DOI: 10.3390/pr9010067

A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms

Schütz C, Ho D, Hamed M, Abdelsamie A, Röhrig T, Herr C, Kany A, Rox K, Schmelz S, Siebenbürger L, …, Lehr C, Empting M (2021)

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8 (12)DOI: 10.1002/advs.202004369

A pulmonary mucus surrogate for investigating antibiotic permeation and activity against Pseudomonas aeruginosa biofilms

Frisch S, Boese A, Huck B, Horstmann J, Ho D, Schwarzkopf K, Murgia X, Loretz B, Souza Carvalho-Wodarz C, Lehr C (2021)

The Journal of antimicrobial chemotherapy 76 (6): 1472-1479DOI: 10.1093/jac/dkab068

Drug delivery for fighting infectious diseases: a global perspective

Loretz B, Oh Y, Hudson S, Gu Z, Lehr C (2021)

Drug delivery and translational research 11 (4): 1316-1322DOI: 10.1007/s13346-021-01009-1

Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals

Thiyagarajan D, Huck B, Nothdurft B, Koch M, Rudolph D, Rutschmann M, Feldmann C, Hozsa C, Furch M, Besecke K, …, Loretz B, Lehr C (2021)

Drug delivery and translational research 11 (4): 1766-1778DOI: 10.1007/s13346-021-01011-7

Surfactant-Free Glibenclamide Nanoparticles: Formulation, Characterization and Evaluation of Interactions with Biological Barriers

Arrua E, Hartwig O, Ho D, Loretz B, Murgia X, Salomon C, Lehr C (2021)

Pharmaceutical research 38 (6): 1081-1092DOI: 10.1007/s11095-021-03056-2

2020

Synthesis and Biopharmaceutical Characterization of Amphiphilic Squalenyl Derivative Based Versatile Drug Delivery Platform

Ho D, Christmann R, Murgia X, Rossi C, Frisch S, Koch M, Schaefer U, Loretz B, Desmaele D, Couvreur P, Lehr C (2020)

Frontiers in chemistry 8DOI: 10.3389/fchem.2020.584242

Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases

Christmann R, Ho D, Wilzopolski J, Lee S, Koch M, Loretz B, Vogt T, Bäumer W, Schaefer U, Lehr C (2020)

Pharmaceutics 12 (12)DOI: 10.3390/pharmaceutics12121131

Polymer-Cargo-Complexes compremising cross-linked copolymers and cargo molecules

Lee S, Loretz B, Lehr C, Hirsch A (2020)

Patent

Nanoparticle Targeting to Scalp Hair Follicles: New Perspectives for a Topical Therapy for Alopecia Areata

Christmann R, Thomas C, Jager N, Raber A, Loretz B, Schaefer U, Tschernig T, Vogt T, Lehr C (2020)

The Journal of investigative dermatology 140 (1): 243-246DOI: 10.1016/j.jid.2019.05.028

pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers

Lee S, Kaya C, Jang H, Koch M, Loretz B, Buhler E, Lehr C, Hirsch A (2020)

Mater. Chem. Front. 4 (3): 905-909DOI: 10.1039/C9QM00651F

Itaconic Acid Increases the Efficacy of Tobramycin against Pseudomonas aeruginosa Biofilms

Ho D, Rossi C, Loretz B, Murgia X, Lehr C (2020)

Pharmaceutics 12 (8)DOI: 10.3390/pharmaceutics12080691

Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections

Ho D, Murgia X, Rossi C, Christmann R, Hüfner de Mello Martins A, Koch M, Andreas A, Herrmann J, Müller R, Empting M, …, Couvreur P, Lehr C (2020)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202001407

2019

Macro- and Microrheological Properties of Mucus Surrogates in Comparison to Native Intestinal and Pulmonary Mucus

Huck B, Hartwig O, Biehl A, Schwarzkopf K, Wagner C, Loretz B, Murgia X, Lehr C (2019)

Biomacromolecules 20 (9): 3504-3512DOI: 10.1021/acs.biomac.9b00780

Challenges and Strategies in Drug Delivery Systems for Treatment of Pulmonary Infections

Ho D, Nichols B, Edgar K, Murgia X, Loretz B, Lehr C (2019)

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.VDOI: 10.1016/j.ejpb.2019.09.002

Bioinspired Liposomes for Oral Delivery of Colistin to Combat Intracellular Infections by Salmonella enterica

Menina S, Eisenbeis J, Kamal M, Koch M, Bischoff M, Gordon S, Loretz B, Lehr C (2019)

Advanced healthcare materials 8 (17)DOI: 10.1002/adhm.201900564

Preferential uptake of chitosan-coated PLGA nanoparticles by primary human antigen presenting cells

Durán V, Yasar H, Becker J, Thiyagarajan D, Loretz B, Kalinke U, Lehr C (2019)

Nanomedicine : nanotechnology, biology, and medicine 21DOI: 10.1016/j.nano.2019.102073

2018

Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles

Yasar H, Biehl A, Rossi C, Koch M, Murgia X, Loretz B, Lehr C (2018)

Journal of nanobiotechnology 16 (1)DOI: 10.1186/s12951-018-0401-y

The role of mucus on drug transport and its potential to affect therapeutic outcomes

Murgia X, Loretz B, Hartwig O, Hittinger M, Lehr C (2018)

Advanced Drug Delivery Reviews 124: 82-97DOI: 10.1016/j.addr.2017.10.009

Oral delivery of macromolecular drugs

Savla R, Hartwig O, Lim Chin W, Loretz B, Lehr C (2018)

Pharm. Technol. Eur. 30 (7): 22-26

Can lifecycle management safeguard innovation in the pharmaceutical industry?

Hering S, Loretz B, Friedli T, Lehr C, Stieneker F (2018)

Drug Discovery TodayDOI: 10.1016/j.drudis.2018.10.008

Farnesylated Glycol Chitosan as a Platform for Drug Delivery

Ho D, Frisch S, Biehl A, Terriac E, Rossi C, Schwarzkopf K, Lautenschläger F, Loretz B, Murgia X, Lehr C (2018)

Biomacromolecules 19 (8): 3489-3501DOI: 10.1021/acs.biomac.8b00795

Chemically modified h CFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis

Haque, A. K. M. Ashiqul, Dewerth A, Antony J, Riethmüller J, Schweizer G, Weinmann P, Latifi N, Yasar H, Pedemonte N, …, Handgretinger R, Kormann M (2018)

Scientific Reports 8 (1)DOI: 10.1038/s41598-018-34960-0

Polysaccharide Submicrocarrier for Improved Pulmonary Delivery of Poorly Soluble Anti-infective Ciprofloxacin

Ho D, Costa A, Rossi C, Souza Carvalho-Wodarz C, Loretz B, Lehr C (2018)

Molecular pharmaceutics 15 (3): 1081-1096DOI: 10.1021/acs.molpharmaceut.7b00967

A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes

Serr I, Scherm M, Zahm A, Schug J, Flynn V, Hippich M, Kälin S, Becker M, Achenbach P, Nikolaev A, …, Ziegler A, Daniel C (2018)

Science translational medicine 10 (422)DOI: 10.1126/scitranslmed.aag1782

Co-culture of human alveolar epithelial (hAELVi) and macrophage (THP-1) cell lines

Kletting S, Barthold S, Repnik U, Griffiths G, Loretz B, Schneider-Daum N, Souza Carvalho-Wodarz C, Lehr C (2018)

ALTEX 35 (2): 211-222DOI: 10.14573/altex.1607191

Starch-Chitosan Polyplexes

Yasar H, Ho D, Rossi C, Herrmann J, Gordon S, Loretz B, Lehr C (2018)

Polymers 10 (3)DOI: 10.3390/polym10030252

Postmenopausaler Lichen planopilaris alias fibrosierende frontotemporale Alopezie Kossard

Vogt T, Thomas C, Reichrath J, Schilling L, Mawlood D, Christmann R, Loretz B, Schäfer U, Lehr C, Müller C (2018)

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 69 (2): 134-142DOI: 10.1007/s00105-017-4118-x

2017

Permanent gene correction by means of nucleotide-modified messenger RNA

Kormann M, Lehr C, Loretz B, Malaeksefat E (2017)

Patent (DE/08.10.13/ DEA102013111099)

Modelling the bronchial barrier in pulmonary drug delivery

Murgia X, Yasar H, Carvalho-Wodarz C, Loretz B, Gordon S, Schwarzkopf K, Schaefer U, Lehr C (2017)

European Journal of Pharmaceutics and Biopharmaceutics 118: 79-88DOI: 10.1016/j.ejpb.2017.03.020

Biodegradable starch derivatives with tunable charge density-synthesis, characterization, and transfection efficiency

Thiele C, Loretz B, Lehr C (2017)

Drug delivery and translational research 7 (2): 252-258DOI: 10.1007/s13346-016-0333-8

2016

Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities

Mostaghaci B, Loretz B, Lehr C (2016)

Current Pharmaceutical Design 22 (11): 1529-33

Preparation of nanosized coacervates of positive and negative starch derivatives intended for pulmonary delivery of proteins

Barthold S, Kletting S, Taffner J, De Souza Carvalho-Wodarz C, Lepeltier E, Loretz B, Lehr C (2016)

Journal of Materials Chemistry B 4 (13): 2377-2386DOI: 10.1039/c6tb00178e

Self-Assembly and Shape Control of Hybrid Nanocarriers Based on Calcium Carbonate and Carbon Nanodots

Lauth V, Loretz B, Lehr C, Maas M, Rezwan K (2016)

Chemistry of Materials 28 (11): 3796-3803DOI: 10.1021/acs.chemmater.6b00769

Design of Polyamine-Grafted Starches for Nucleotide Analogue Delivery: In Vitro Evaluation of the Anticancer Activity

Kanber E, Yamada H, Loretz B, Lepeltier E, Lehr C (2016)

Bioconjugate chemistryDOI: 10.1021/acs.bioconjchem.6b00396

Autologous co-culture of primary human alveolar macrophages and epithelial cells for investigating aerosol medicines. Part II: evaluation of IL-10-loaded microparticles for the treatment of lung inflammation

Hittinger M, Mell N, Huwer H, Loretz B, Schneider-Daum N, Lehr C (2016)

Alternatives to laboratory animals : ATLA 44 (4): 349-360

miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity

Serr I, Furst R, Ott V, Scherm M, Nikolaev A, Gokmen F, Kalin S, Zillmer S, Bunk M, Weigmann B, …, Ziegler A, Daniel C (2016)

Proceedings of the National Academy of Sciences of the United States of America 113 (43): 6659-DOI: 10.1073/pnas.1606646113

2015

Overview of Inhaled Nanopharmaceuticals

Barthold S, Kunschke N, Murgia X, Loretz B, Carvalho Wodarz C, Lehr C (2015)

Book

P-glycoprotein interactions of novel psychoactive substances - stimulation of ATP consumption and transport across Caco-2 monolayers

Meyer M, Wagmann L, Schneider-Daum N, Loretz B, Souza Carvalho C, Lehr C, Maurer H (2015)

Biochemical pharmacology 94 (3): 220-6DOI: 10.1016/j.bcp.2015.01.008

Enhanced uptake and siRNA-mediated knockdown of a biologically relevant gene using cyclodextrin polyrotaxane

Dandekar P, Jain R, Keil M, Loretz B, Koch M, Wenz G, Lehr C (2015)

Journal of Materials Chemistry B 3 (13): 2590-2598DOI: 10.1039/c4tb01821d

Transfection system of amino-functionalized calcium phosphate nanoparticles: in vitro efficacy, biodegradability, and immunogenicity study

Mostaghaci B, Susewind J, Kickelbick G, Lehr C, Loretz B (2015)

ACS applied materials & interfaces 7 (9): 5124-33DOI: 10.1021/am507193a

Cyclodextrin-based star polymers as a versatile platform for nanochemotherapeutics: Enhanced entrapment and uptake of idarubicin

Nafee N, Hirosue M, Loretz B, Wenz G, Lehr C (2015)

Colloids and surfaces. B, Biointerfaces 129: 30-8DOI: 10.1016/j.colsurfb.2015.03.014

Dimethylaminoethyl methacrylate copolymer-siRNA nanoparticles for silencing a therapeutically relevant gene in macrophages

Jain R, Dandekar P, Loretz B, Koch M, Lehr C (2015)

MedChemComm 6 (4): 691-701DOI: 10.1039/c4md00490f

Squalenoylation of Chitosan: A Platform for Drug Delivery?

Lepeltier E, Loretz B, Desmaele D, Zapp J, Herrmann J, Couvreur P, Lehr C (2015)

Biomacromolecules 16 (9): 2930-9DOI: 10.1021/acs.biomac.5b00840

In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency

Mahiny A, Dewerth A, Mays L, Alkhaled M, Mothes B, Malaeksefat E, Loretz B, Rottenberger J, Brosch D, Reautschnig P, …, Lehr C, Kormann M (2015)

Nature biotechnology 33 (6): 584-6DOI: 10.1038/nbt.3241

2014

Design of starch-graft-PEI polymers: an effective and biodegradable gene delivery platform

Yamada H, Loretz B, Lehr C (2014)

Biomacromolecules 15 (5): 1753-61DOI: 10.1021/bm500128k

Polyester-idarubicin nanoparticles and a polymer-photosensitizer complex as potential drug formulations for cell-mediated drug delivery

Blaudszun A, Lian Q, Schnabel M, Loretz B, Steinfeld U, Lee H, Wenz G, Lehr C, Schneider M, Philippi A (2014)

International journal of pharmaceutics 474 (1-2): 70-9DOI: 10.1016/j.ijpharm.2014.07.048

2013

Crossing biological barriers for advanced drug delivery

Schneider M, Windbergs M, Daum N, Loretz B, Collnot E, Hansen S, Schaefer U, Lehr C (2013)

European Journal of Pharmaceutics and Biopharmaceutics 84 (2): 239-241DOI: 10.1016/j.ejpb.2013.03.009

One-step synthesis of nanosized and stable amino-functionalized calcium phosphate particles for DNA transfection

Mostaghaci B, Loretz B, Haberkorn R, Kickelbick G, Lehr C (2013)

Chemistry of Materials 25 (18): 3667-3674DOI: 10.1021/cm401886u

2012

Cellular delivery of polynucleotides by cationic cyclodextrin polyrotaxanes

Dandekar P, Jain R, Keil M, Loretz B, Muijs L, Schneider M, Auerbach D, Jung G, Lehr C, Wenz G (2012)

Journal of controlled release : official journal of the Controlled Release Society 164 (3): 387-93DOI: 10.1016/j.jconrel.2012.06.040

A hydrophobic starch polymer for nanoparticle-mediated delivery of docetaxel

Dandekar P, Jain R, Stauner T, Loretz B, Koch M, Wenz G, Lehr C (2012)

Macromolecular Bioscience 12 (2): 184-94DOI: 10.1002/mabi.201100244

Pulmonary delivery and tissue distribution of aerosolized antisense 2'-O-Methyl RNA containing nanoplexes in the isolated perfused and ventilated rat lung

Dong M, Murdter T, Philippi C, Loretz B, Schaefer U, Lehr C, Schwab M, Ammon-Treiber S (2012)

European Journal of Pharmaceutics and Biopharmaceutics 81 (3): 478-85DOI: 10.1016/j.ejpb.2012.04.022

2011

Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2'-O-methyl-RNA

Dong M, Philippi C, Loretz B, Nafee N, Schaefer U, Friedel G, Ammon-Treiber S, Griese E, Lehr C, Klotz U, Murdter T (2011)

International journal of pharmaceutics 419 (1-2): 33-42DOI: 10.1016/j.ijpharm.2011.07.009

Enhanced cellular delivery of idarubicin by surface modification of propyl starch nanoparticles employing pteroic acid conjugated polyvinyl alcohol

Jain R, Dandekar P, Loretz B, Melero A, Stauner T, Wenz G, Koch M, Lehr C (2011)

International journal of pharmaceutics 420 (1): 147-55DOI: 10.1016/j.ijpharm.2011.08.030

2010

Telomerase as an emerging target to fight cancer - Opportunities and challenges for nanomedicine

Philippi C, Loretz B, Schaefer U, Lehr C (2010)

Journal of Controlled Release 146 (2): 228-240DOI: 10.1016/j.jconrel.2010.03.025

Nanoparticles made from novel starch derivatives for transdermal drug delivery

Santander-Ortega M, Stauner T, Loretz B, Ortega-Vinuesa J, Bastos-Gonzalez D, Wenz G, Schaefer U, Lehr C (2010)

Journal of controlled release : official journal of the Controlled Release Society 141 (1): 85-92DOI: 10.1016/j.jconrel.2009.08.012