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Zebrafish Facility
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and importantly, we developed a number of infection models for early in vivo screening. As part of drug metabolism and pharmacokinetic (DMPK) studies, we recently established a method for studying the spatial
interesting enzymes usable in the lab, and applying them for efficient biocatalytic or chemo-enzymatic drug synthesis. Overall, our research not only enables efficient exploration of natural products, but also
Read moreAnna-Lisa Klein
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system for the zebrafish larvae toxicity model. This system aims to detect toxic side effects of drug candidates at an early stage. In the future, this should facilitate preclinical research on natural
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Monoclonal Human Alveolar Epithelial Cell Line (“Arlo”) with Pronounced Barrier Function for Studying Drug Permeability and Viral Infections Read more Persicamidines—Unprecedented Sesquarterpenoids with Potent
ICA2027
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advances in anti-infective discovery and development — from biosynthesis and microbiome research to drug design, computational approaches, and translation into industry. Invited Speakers Invited Speaker
therefore, lies in making smart, purposeful data splits. In a new study, Prof Olga Kalinina, head of the Drug Bioinformatics group at HIPS, her PhD student Roman Joeres, and Prof David Blumenthal from FAU demonstrate [...] It can also automatically…
Dr Carsten Volz
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exciting biological activities. Many of these compounds can potentially be developed into powerful drugs against a number of diseases. Nevertheless, biosynthesis of biologically active compounds is commonly
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explains Dr. Jörg Haupenthal, a scientist in the team of Professor Anna Hirsch, head of the department “Drug Design and Optimization” at HIPS. Haupenthal is leading a project focused on developing new treatments [...] controlling P. aeruginosa…
killing algae or even human cells. Furanolides thus offer a promising basis for the development of new drugs. In addition to cyanobacteria and myxobacteria, natural sources of furanolides include some marine [...] were able to kill human cancer cells…
The production process was established by Prof. Marc Stadler, head of the department “Microbial Drugs” at HZI, while orally available formulations were developed in Bonn under Prof. Karl Wagner (supported [...] partners, the GHIT Fund mobilizes…