Dr Judith Hoffmann
About
Judith studied Chemistry at Saarland University and passed her diploma degree in 2009. After an internship in 2010 at the Novartis Institute for BioMedical Research (NIBR) in Basel, she started her PhD thesis in organic chemistry in the group of Prof. Uli Kazmaier, (Saarland University) and got her degree in October 2014. Since July 2014, she works as a scientist in the HIPS-department Microbial Natural Products.
Her research focus concentrates on the isolation and structure elucidation of new myxobacterial secondary metabolites as well as the synthesis and semisynthesis of small molecules and new derivatives. She is the contact person and responsible for the NMR platforms and the NMR Software and Database.
2023
Adaptations of Pseudoxylaria towards a comb-associated lifestyle in fungus-farming termite colonies
Fricke J, Schalk F, Kreuzenbeck N, Seibel E, Hoffmann J, Dittmann G, Conlon B, Guo H, Wilhelm de Beer Z, Vassão D, …, Poulsen M, Beemelmanns C (2023)
ISME J.: 1-15DOI: 10.1038/s41396-023-01374-4
2022
Expanding the Ajudazol Cytotoxin Scaffold: Insights from Genome Mining, Biosynthetic Investigations, and Novel Derivatives
Zeng H, Birkelbach J, Hoffmann J, Popoff A, Volz C, Müller R (2022)
Journal of natural productsDOI: 10.1021/acs.jnatprod.2c00637
Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin
Couturier C, Groß S, Tesmar A, Hoffmann J, Deckarm S, Fievet A, Dubarry N, Taillier T, Pöverlein C, Stump H, …, Müller R, Renard S (2022)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202210747
2019
Armeniaspirol Antibiotic Biosynthesis: Chlorination and Oxidative Dechlorination Steps Affording Spiro4.4non-8-ene
Fu C, Xie F, Hoffmann J, Wang Q, Bauer A, Brönstrup M, Mahmud T, Müller R (2019)
ChemBioChem 20 (6): 764-769DOI: 10.1002/cbic.201800791
2017
AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus
Bock T, Luxenburger E, Hoffmann J, Schütza V, Feiler C, Müller R, Blankenfeldt W (2017)
Angewandte Chemie (International ed. in English) 56 (33): 9986-9989DOI: 10.1002/anie.201701992
2016
Isolation, Structure Elucidation, Biosynthesis, and Synthesis of Antalid, a Secondary Metabolite from Polyangium species
Tautz T, Hoffmann J, Hoffmann T, Steinmetz H, Washausen P, Kunze B, Huch V, Kitsche A, Reichenbach H, Höfle G, Müller R, Kalesse M (2016)
Org. Lett. 18 (11): 2560-3DOI: 10.1021/acs.orglett.6b00810
2015
Synthesis of pretubulysin-derivatives via the TubUgi-approach
Hoffmann J, Gorges J, Junk L, Kazmaier U (2015)
Org. Biomol. Chem. 13 (21): 6010-20DOI: 10.1039/C5OB00587F
Development of a New NPPOC-Derived Photolabile Protecting Group Suitable for Cyclizations via Ring Closing Metathesis
Hoffmann J, Kazmaier U (2015)
COS 12 (4): 475-483DOI: 10.2174/1570179412666150505185015
Synthesis of Cyclic Peptides through Ring-Closing Metathesis of Photolabile Protecting Groups
Hoffmann J, Kazmaier U (2015)
Synthesis 47 (03): 411-420DOI: 10.1055/s-0034-1378908
Pinensins: the first antifungal lantibiotics
Mohr K, Volz C, Jansen R, Wray V, Hoffmann J, Bernecker S, Wink J, Gerth K, Stadler M, Müller R (2015)
Angew. Chem. Int. Ed. Engl. 127 (38): 11254-11258DOI: 10.1002/anie.201500927
2014
Eine niedermolekulare Verbindung inhibiert die Proteindisulfidisomerase und sensibilisiert Krebszellen für die Chemotherapie
Eirich J, Braig S, Schyschka L, Servatius P, Hoffmann J, Hecht S, Fulda S, Zahler S, Antes I, Kazmaier U, Sieber S, Vollmar A (2014)
Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 126 (47): 13174-13179DOI: 10.1002/ange.201406577
Ein einfacher Zugang zu cyclischen photoaktivierbaren Tubulysin-Derivaten
Hoffmann J, Kazmaier U (2014)
Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 126 (42): 11538-11542DOI: 10.1002/ange.201405650
2013
Synthetic Approaches Towards Tubulysins and Derivatives Thereof
Kazmaier U, Hoffmann J (2013)
TONPJ 6 (1): 12-30DOI: 10.2174/1874848101306010012