Researcher in Laboratory © HIPS

Dr Judith Hoffmann


Judith studied Chemistry at Saarland University and passed her diploma degree in 2009. After an internship in 2010 at the Novartis Institute for BioMedical Research (NIBR) in Basel, she started her PhD thesis in organic chemistry in the group of Prof. Uli Kazmaier, (Saarland University) and got her degree in October 2014. Since July 2014, she works as a scientist in the HIPS-department Microbial Natural Products.
Her research focus concentrates on the isolation and structure elucidation of new myxobacterial secondary metabolites as well as the synthesis and semisynthesis of small molecules and new derivatives. She is the contact person and responsible for the NMR platforms and the NMR Software and Database.


Adaptations of Pseudoxylaria towards a comb-associated lifestyle in fungus-farming termite colonies

Fricke J, Schalk F, Kreuzenbeck N, Seibel E, Hoffmann J, Dittmann G, Conlon B, Guo H, Wilhelm de Beer Z, Vassão D, …, Poulsen M, Beemelmanns C (2023)

ISME J.: 1-15DOI: 10.1038/s41396-023-01374-4


Expanding the Ajudazol Cytotoxin Scaffold: Insights from Genome Mining, Biosynthetic Investigations, and Novel Derivatives

Zeng H, Birkelbach J, Hoffmann J, Popoff A, Volz C, Müller R (2022)

Journal of natural productsDOI: 10.1021/acs.jnatprod.2c00637

Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin

Couturier C, Groß S, Tesmar A, Hoffmann J, Deckarm S, Fievet A, Dubarry N, Taillier T, Pöverlein C, Stump H, …, Müller R, Renard S (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202210747


Armeniaspirol Antibiotic Biosynthesis: Chlorination and Oxidative Dechlorination Steps Affording Spiro4.4non-8-ene

Fu C, Xie F, Hoffmann J, Wang Q, Bauer A, Brönstrup M, Mahmud T, Müller R (2019)

ChemBioChem 20 (6): 764-769DOI: 10.1002/cbic.201800791


AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus

Bock T, Luxenburger E, Hoffmann J, Schütza V, Feiler C, Müller R, Blankenfeldt W (2017)

Angewandte Chemie (International ed. in English) 56 (33): 9986-9989DOI: 10.1002/anie.201701992


Isolation, Structure Elucidation, Biosynthesis, and Synthesis of Antalid, a Secondary Metabolite from Polyangium species

Tautz T, Hoffmann J, Hoffmann T, Steinmetz H, Washausen P, Kunze B, Huch V, Kitsche A, Reichenbach H, Höfle G, Müller R, Kalesse M (2016)

Org. Lett. 18 (11): 2560-3DOI: 10.1021/acs.orglett.6b00810


Synthesis of pretubulysin-derivatives via the TubUgi-approach

Hoffmann J, Gorges J, Junk L, Kazmaier U (2015)

Org. Biomol. Chem. 13 (21): 6010-20DOI: 10.1039/C5OB00587F

Development of a New NPPOC-Derived Photolabile Protecting Group Suitable for Cyclizations via Ring Closing Metathesis

Hoffmann J, Kazmaier U (2015)

COS 12 (4): 475-483DOI: 10.2174/1570179412666150505185015

Synthesis of Cyclic Peptides through Ring-Closing Metathesis of Photolabile Protecting Groups

Hoffmann J, Kazmaier U (2015)

Synthesis 47 (03): 411-420DOI: 10.1055/s-0034-1378908

Pinensins: the first antifungal lantibiotics

Mohr K, Volz C, Jansen R, Wray V, Hoffmann J, Bernecker S, Wink J, Gerth K, Stadler M, Müller R (2015)

Angew. Chem. Int. Ed. Engl. 127 (38): 11254-11258DOI: 10.1002/anie.201500927


Eine niedermolekulare Verbindung inhibiert die Proteindisulfidisomerase und sensibilisiert Krebszellen für die Chemotherapie

Eirich J, Braig S, Schyschka L, Servatius P, Hoffmann J, Hecht S, Fulda S, Zahler S, Antes I, Kazmaier U, Sieber S, Vollmar A (2014)

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 126 (47): 13174-13179DOI: 10.1002/ange.201406577

Ein einfacher Zugang zu cyclischen photoaktivierbaren Tubulysin-Derivaten

Hoffmann J, Kazmaier U (2014)

Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 126 (42): 11538-11542DOI: 10.1002/ange.201405650


Synthetic Approaches Towards Tubulysins and Derivatives Thereof

Kazmaier U, Hoffmann J (2013)

TONPJ 6 (1): 12-30DOI: 10.2174/1874848101306010012