Search
Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes
Publication
Chan A,
Ho T,
Fathoni I,
Hamid R,
Hirsch A,
Saliba K,
Leeper F
(2024)
RSC Med. Chem., 15, 5, 1773-1781, 10.1039/D4MD00083H, 38784473
RSC Med. Chem., 15, 5, 1773-1781, 10.1039/D4MD00083H, 38784473
Studying Target-Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry
Publication
Bizzarri L,
Steinbrunn D,
Quennesson T,
Lacour A,
Bianchino G,
Bravo P,
Chaignon P,
Lohse J,
Mäser P,
Seemann M,
van Calenbergh S,
Hirsch A,
Hahne H
(2024)
ACS Infect. Dis., 10, 12, 4087-4102, 10.1021/acsinfecdis.4c00417, 39566904
ACS Infect. Dis., 10, 12, 4087-4102, 10.1021/acsinfecdis.4c00417, 39566904
Synthesis and Structure of a Coordination Polymer of Ni(II) with 2-(4-Bromophenoxy)acetohydrazide
Publication
Martsynko ?,
Nesterkina M,
Finik ?,
Tsymbaliuk K,
Dyakonenko V,
Shishkina S,
Kravchenko I
(2024)
Molbank, 2024, 2, 10.3390/M1819
Molbank, 2024, 2, 10.3390/M1819
Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy-coupling factor transporters (ECFTs)
Publication
Haupenthal J,
Rafehi M,
Kany A,
Lespine A,
Stefan K,
Hirsch* A,
Stefan* S
(2024)
Arch. Pharm., 10.1002/ardp.202400267, 38896404
Arch. Pharm., 10.1002/ardp.202400267, 38896404
Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor
Publication
Drost M,
Diamanti E,
Fuhrmann K,
Goes A,
Shams A,
Haupenthal J,
Koch M,
Hirsch A,
Fuhrmann G
(2022)
Pharmaceutics, 14, 1, 10.3390/pharmaceutics14010004
Pharmaceutics, 14, 1, 10.3390/pharmaceutics14010004
Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors
Publication
Wimmer S,
Hoff K,
Martin B,
Grewer M,
Denni L,
Lascorz Massanet R,
Raimondi M,
Bülbül E,
Melesina J,
Hotop S,
Haupenthal J,
Rohde H,
Heisig P,
Hirsch A,
Brönstrup M,
Sippl W,
Holl R
(2022)
Bioorganic chemistry, 131, 10.1016/j.bioorg.2022.106331, 36587505
Bioorganic chemistry, 131, 10.1016/j.bioorg.2022.106331, 36587505
New Ketene Dithioacetals Generated from 2-Nitroperchlorobutadiene and Investigation of Their Antibacterial, Antifungal, Anticonvulsant and Antidepressant Activities
Publication
Aydinli S,
Bulut E,
Deniz N,
Sayil C,
Komarovska-Porokhnyavets O,
Lubenets V,
Zvarych V,
Stasevych M,
Nesterkina M,
Kravchenko I
(2022)
Chemistry & Biodiversity, 19, 7, 10.1002/cbdv.202100931, 35674435
Chemistry & Biodiversity, 19, 7, 10.1002/cbdv.202100931, 35674435
Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases
Publication
Alhayek A,
Abdelsamie A,
Schönauer E,
Camberlein V,
Hutterer E,
Posselt G,
Serwanja J,
Blöchl C,
Huber C,
Haupenthal J,
Brandstetter H,
Wessler S,
Hirsch A
(2022)
Journal of medicinal chemistry, 65, 19, 12933-12955, 10.1021/acs.jmedchem.2c00785, 36154055
Journal of medicinal chemistry, 65, 19, 12933-12955, 10.1021/acs.jmedchem.2c00785, 36154055
(1 R ,2 S ,5 R )-5-Methyl-2-(propan-2-yl)cyclohexyl 4-amino-3-phenylbutanoate hydrochloride: Synthesis and anticonvulsant activity
Publication
Nesterkina M,
Musatov V,
Honcharova O,
Kravchenko I
(2022)
Open Chemistry, 20, 1, 703-707, 10.1515/chem-2022-0189
Open Chemistry, 20, 1, 703-707, 10.1515/chem-2022-0189
An Efficient Way to Screen Inhibitors of Energy-Coupling Factor (ECF) Transporters in a Bacterial Uptake Assay
Publication
Bousis S,
Winkler S,
Haupenthal J,
Fulco F,
Diamanti E,
Hirsch A
(2022)
International journal of molecular sciences, 23, 5, 10.3390/ijms23052637, 35269783
International journal of molecular sciences, 23, 5, 10.3390/ijms23052637, 35269783