EN | DE
 info(at)helmholtz-hips.de +49681988063001
 Directions to Google
EN | DE
Researchers in HIPS Laboratory

Search

Searched for "drug". Displaying results 681 to 690 of 775.

Integral Solvent-Induced Protein Precipitation for Target-Engagement Studies in Plasmodium falciparum

Publication
Bravo P, Bizzarri L, Steinbrunn D, Lohse J, Hirsch A, Mäser P, Rottmann M, Hahne H (2024)
ACS Infect. Dis., 10, 12, 4073-4086, 10.1021/acsinfecdis.4c00418, 39631773

Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT

Publication
Exapicheidou I, Shams A, Ibrahim H, Tsarenko A, Backenköhler M, Hamed M, Diamanti E, Volkamer A, slotboom d, Hirsch A (2024)
Chem. Commun., 60, 7, 870-873, 10.1039/D3CC04738E, 38164786

Identification of inhibitors targeting the energy-coupling factor (ECF) transporters

Publication
Diamanti E, Souza P, Setyawati I, Bousis S, Monjas L, Swier L, Shams A, Tsarenko A, Stanek W, Jäger M, Marrink S, slotboom d, Hirsch A (2024)
Communications Biology, 7, 1, 10.1038/s42003-024-05770-0, 38195913

IspE kinase as an anti-infective target: Role of a hydrophobic pocket in inhibitor binding

Publication
Hamid R, Walsh D, Diamanti E, Aguilar D, Lacour A, Hamed M, Hirsch A (2024)
Structure (London, England : 1993), 32, 12, 2390-2398, 10.1016/j.str.2024.10.009, 39510075

High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum

Publication
Johannsen S, Gierse R, Krüger A, Edwards R, Nanna V, Fontana A, Di Zhu, Masini T, Carvalho L, Poizat M, Kieftenbelt B, Hodge D, Alvarez S, Bunt D, Lacour A, Shams A, Meissner K, Souza E, Dröge M, van Vliet B, Hartog J, Hutter M, Held J, Odom John A, Wrenger C, Hirsch* A (2024)
ACS Infect. Dis., 10.1021/acsinfecdis.3c00670, 38367280

Targeting the Plasmodium falciparum IspE Enzyme

Publication
Diamanti E, Steinbach A, Carvalho L, Ropponen H, Lacour A, Hamid R, Eisa S, Bravo P, Bousis S, Illarionov B, Fischer M, Hamed M, Bach N, Rottmann M, Held J, Witschel M, Sieber S, Hirsch A (2024)
ACS omega, 9, 44, 44465-44473, 10.1021/acsomega.4c06038, 39524657

Behavioral and electrophysiological responses of the male medfly, Ceratitis capitata, to thymol and carvacrol ethers

Publication
Tabanca N, Cloonan K, Nesterkina M, Gill M, Montgomery W, Kravchenko I, Kendra P (2024)
Pest management science, 10.1002/ps.8324, 39096116

Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes

Publication
Chan A, Ho T, Fathoni I, Hamid R, Hirsch A, Saliba K, Leeper F (2024)
RSC Med. Chem., 15, 5, 1773-1781, 10.1039/D4MD00083H, 38784473

Multiparameter Optimization of Pseudomonas aeruginosa Elastase Inhibitors for Systemic Administration

Publication
Abdelsamie A, Konstantinovic J, Kany A, Schütz C, Kolling D, Speicher S, Klein A, Shafiei R, Bouté M, Mundry K, Park Y, Loretz B, Müller R, Sallenave J, Lehr C, Koehnke J, Rox K, Haupenthal J, Hirsch A (2026)
Journal of medicinal chemistry, 69, 4, 4160-4186, 10.1021/acs.jmedchem.5c02788, 41642952

An investigation of phosphinamides as a functional group for medicinal chemistry

Publication
Meurillon V, Blanchart P, Ullah V, Chan D, Perry M (2026)
Med Chem Res, 35, 1, 118-134, 10.1007/s00044-025-03498-y