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Researcher in Laboratory © HIPS

Selina Deckarm

About

Selina Deckarm studied human- and molecular biology at the University of Saarland in Saarbrücken from October 2015 to April 2021. She did her bachelor thesis in the field of virology in the research group of Prof. Dr. med. Sigrun Smola and her master thesis in the field of microbial natural products in the research group of Prof. Dr. Rolf Müller at HIPS. In parallel to her studies, Selina Deckarm worked for 8 months as a student employee at HIPS and volunteered 2 years in the biology student council. Since November 2018, she is part of the Life Sciences Student Initiative (btS) and she organized the 1st HIPS Information Day for students in cooperation of the btS with HIPS.

In May 2021, Selina Deckarm continued her scientific career in Prof. Müller's group, where she is currently working as a PhD student. She focuses on heterologous expression and genetic modification of bacterial natural product biosynthetic pathways including the goals: to improve production yields, to elucidate the biosynthesis and to develop new promising myxobacterial antibiotics.


2024

The Peptide Antibiotic Corramycin Adopts a β-Hairpin-like Structure and Is Inactivated by the Kinase ComG

Adam S, Fries F, Tesmar A, Rasheed S, Deckarm S, Sousa C, Reberšek R, Risch T, Mancini S, Herrmann J, …, Kalinina O, Müller R (2024)

J. Am. Chem. Soc.DOI: 10.1021/jacs.3c13208

2022

Darobactins Exhibiting Superior Antibiotic Activity by Cryo-EM Structure Guided Biosynthetic Engineering

Seyfert C, Porten C, Yuan B, Deckarm S, Panter F, Bader C, Coetzee J, Deschner F, Tehrani K, Higgins P, …, Herrmann J, Müller R (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202214094

Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin

Couturier C, Groß S, Tesmar A, Hoffmann J, Deckarm S, Fievet A, Dubarry N, Taillier T, Pöverlein C, Stump H, …, Müller R, Renard S (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202210747

2021

Improved broad-spectrum antibiotics against Gram-negative pathogens via darobactin biosynthetic pathway engineering

Groß S, Panter F, Pogorevc D, Seyfert C, Deckarm S, Bader C, Herrmann J, Müller R (2021)

Chem. Sci. 12 (35): 11882-11893DOI: 10.1039/d1sc02725e