Dr Sebastian Walesch
About
Sebastian Walesch studied pharmacy at the University of Freiburg. He prepared his diploma thesis titled “A new Family of Enzymes providing Extender Units for Modular Polyketide Synthases” as a visiting student in the group of Prof. Peter Leadlay at the University of Cambridge and obtained his diploma degree from the University of Freiburg in 2016. After obtaining his license to practice pharmacy in June 2017, Sebastian worked as a pharmacist before joining Prof. Rolf Müllers group at HIPS for his PhD in October 2018.
Sebastian cultivates myxobacteria using different approaches to improve production of bioactive natural products. He then isolates, purifies and investigates those secondary metabolites for their structure, physico-chemical properties, bioactivities, and biosynthesis.
2024
New myxobacteria of the Myxococcaceae clade produce angiolams with antiparasitic activities
Walesch S, Garcia R, Mahmoud A, Panter F, Bollenbach S, Mäser P, Kaiser M, Krug D, Müller R (2024)
Microbiology SpectrumDOI: 10.1128/spectrum.03689-23
2023
Fighting antibiotic resistance-strategies and (pre)clinical developments to find new antibacterials
Walesch S, Birkelbach J, Jézéquel G, Haeckl F, Hegemann J, Hesterkamp T, Hirsch A, Hammann P, Müller R (2023)
EMBO reports 24 (1)DOI: 10.15252/embr.202256033
2022
Current Developments in Antibiotic Discovery – Global Microbial Diversity as Source for Evolutionary Optimized Anti-infectives
Hegemann J, Birkelbach J, Walesch S, Müller R (2022)
EMBO Rep. published concurrently
Current Developments in Antibiotic Discovery – Global Microbial Diversity as Source for Evolutionary Optimized Anti-infectives
Hegemann J, Birkelbach J, Walesch S, Müller R (2022)
EMBO Rep. published concurrently
2021
Structure and Biosynthesis of Myxofacyclines: Unique Myxobacterial Polyketides Featuring Varing and Rare Heterocycles *
Popoff A, Hug J, Walesch S, Garcia R, Keller L, Müller R (2021)
Chem. Eur. J. 27 (67): 16654-16661DOI: 10.1002/chem.202103095