Dr Ronald Garcia
About
Dr. Garcia studied Microbiology in his Bachelor and Masters at the University of Santo Tomas, Manila. After working in industry and academia in the Philippines for a couple of years, he decided to join Rolf Müller’s laboratory for doctoral studies in 2006 under the Department of Pharmaceutical Biotechnology at the Saarland University. When HIPS was founded in 2009, his position was changed under the Helmholtz Center for Infection Research. In 2011, he obtained his Doctor’s degree and since then, he continued his work on microbial natural products and anti-infective research of novel myxobacteria.
Dr. Garcia has shown interest and passion working on combining multidisciplinary fields in microbial diversity, ecology, metagenomics, systematics, phylogenetics, and microbial physiology to unravel the uncultured myxobacteria and their frontier. Through the years, he established a one of a kind strain collection that houses unique and rare myxobacteria for novel natural product discovery, which is primarily aimed at finding novel antibiotics. Currently, he is working on an anti-infective research project from untapped myxobacterial sources to help to combat the problem of human-threatening antibiotic resistance.
2024
New myxobacteria of the Myxococcaceae clade produce angiolams with antiparasitic activities
Walesch S, Garcia R, Mahmoud A, Panter F, Bollenbach S, Mäser P, Kaiser M, Krug D, Müller R (2024)
Microbiology SpectrumDOI: 10.1128/spectrum.03689-23
2023
Discovery and Characterization of a Myxobacterial Lanthipeptide with Unique Biosynthetic Features and Anti-inflammatory Activity
Wang X, Chen X, Wang Z, Zhuang M, Zhong L, Fu C, Garcia R, Müller R, Zhang Y, Yan J, Wu D, Huo L (2023)
J. Am. Chem. Soc. 145 (30): 16924-16937DOI: 10.1021/jacs.3c06014
Structure Elucidation and Biosynthesis of Nannosterols A and B, Myxobacterial Sterols from Nannocystis sp. MNa10993
Akone S, Hug J, Kaur A, Garcia R, Müller R (2023)
Journal of natural products 86 (4): 915-923DOI: 10.1021/acs.jnatprod.2c01143
2022
The inherent antibiotic activity of myxobacteria-derived autofluorescent outer membrane vesicles is switched on and off by light stimulation
Lapuhs P, Heinrich E, Garcia R, Goes A, Frank N, Bollenbach L, Stibane V, Kuhn T, Koch M, Kiemer A, …, Fuhrmann K, Fuhrmann G (2022)
NanoscaleDOI: 10.1039/d2nr02743g
Discovery, Biosynthesis and Biological Activity of a Succinylated Myxochelin from the Myxobacterial strain MSr12020
Okoth D, Hug J, Garcia R, Müller R (2022)
BookDOI: 10.20944/preprints202209.0147.v1
Thiamyxins: Structure and Biosynthesis of Myxobacterial RNA-Virus Inhibitors
Haack P, Harmrolfs K, Bader C, Garcia R, Gunesch A, Haid S, Popoff A, Voltz A, Kim H, Bartenschlager R, Pietschmann T, Müller R (2022)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202212946
Three New Stigmatellin Derivatives Reveal Biosynthetic Insights of Its Side Chain Decoration
Okoth D, Hug J, Garcia R, Müller R (2022)
Molecules (Basel, Switzerland) 27 (14)DOI: 10.3390/molecules27144656
Corallococcus soli sp. Nov., a Soil Myxobacterium Isolated from Subtropical Climate, Chalus County, Iran, and Its Potential to Produce Secondary Metabolites
Babadi Z, Garcia R, Ebrahimipour G, Risdian C, Kämpfer P, Jarek M, Müller R, Wink J (2022)
Microorganisms 10 (7)DOI: 10.3390/microorganisms10071262
Myxobacteria of the Cystobacterineae Suborder Are Producers of New Vitamin K2 Derived Myxoquinones
Panter F, Popoff A, Garcia R, Krug D, Müller R (2022)
Microorganisms 10 (3)DOI: 10.3390/microorganisms10030534
New Deoxyenhygrolides from Plesiocystis pacifica Provide Insights into Butenolide Core Biosynthesis
Hug J, Kjaerulff L, Garcia R, Müller R (2022)
Marine drugs 20 (1)DOI: 10.3390/md20010072
Sandacrabins - Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium
Bader C, Panter F, Garcia R, Tchesnokov E, Haid S, Walt C, Spröer C, Kiefer A, Götte M, Overmann J, Pietschmann T, Müller R (2022)
Chem. Eur. J. 28 (10)DOI: 10.1002/chem.202104484
2021
Structure and Biosynthesis of Myxofacyclines: Unique Myxobacterial Polyketides Featuring Varing and Rare Heterocycles *
Popoff A, Hug J, Walesch S, Garcia R, Keller L, Müller R (2021)
Chem. Eur. J. 27 (67): 16654-16661DOI: 10.1002/chem.202103095
Structure and biosynthesis of sorangipyranone - a new γ-dihydropyrone from the myxobacterial strain MSr12020
Okoth D, Hug J, Mándi A, Kurtán T, Garcia R, Müller R (2021)
Journal of Industrial Microbiology & Biotechnology 48 (3-4)DOI: 10.1093/jimb/kuab029
2020
Myxobacteria-Derived Outer Membrane Vesicles: Potential Applicability Against Intracellular Infections
Goes A, Lapuhs P, Kuhn T, Schulz E, Richter R, Panter F, Dahlem C, Koch M, Garcia R, Kiemer A, Müller R, Fuhrmann G (2020)
Cells 9 (1)DOI: 10.3390/cells9010194
2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene-Nucleoside
Okoth D, Hug J, Garcia R, Spröer C, Overmann J, Müller R (2020)
Molecules (Basel, Switzerland) 25 (11)DOI: 10.3390/molecules25112676
Myxobakterielle Naturstofffabriken
Krug D, Garcia R, Müller R (2020)
Biospektrum 26 (1): 32-36DOI: 10.1007/s12268-020-1334-1
2019
Corrigendum to biocompatible bacteria-derived vesicles show inherent antimicrobial activity (Journal of Controlled Release (2018) 290 (46–55), (S0168365918305698) (10.1016/j.jconrel.2018.09.030))
Schulz E, Goes A, Garcia R, Panter F, Koch M, Müller R, Fuhrmann K, Fuhrmann G (2019)
Journal of Controlled Release 293: 155-157DOI: 10.1016/j.jconrel.2018.11.027
Production of a Dibrominated Aromatic Secondary Metabolite by a Planctomycete Implies Complex Interaction with a Macroalgal Host
Panter F, Garcia R, Thewes A, Zaburannyi N, Bunk B, Overmann J, Gutierrez M, Krug D, Müller R (2019)
ACS Chem. Biol. 14 (accepted // 12): 2713-2719DOI: 10.1021/acschembio.9b00641
Two Biosynthetic Pathways in Jahnella thaxteri for Thaxteramides, Distinct Types of Lipopeptides
Oueis E, Klefisch T, Zaburannyi N, Garcia R, Plaza A, Müller R (2019)
Org. Lett. 21 (14): 5407-5412DOI: 10.1021/acs.orglett.9b01524
2018
Biocompatible bacteria-derived vesicles show inherent antimicrobial activity
Schulz E, Goes A, Garcia R, Panter F, Koch M, Müller R, Fuhrmann K, Fuhrmann G (2018)
Journal of Controlled Release 290: 46-55DOI: 10.1016/j.jconrel.2018.09.030
Metabolic and Biosynthetic Diversity in Marine Myxobacteria
Gemperlein K, Zaburannyi N, Garcia R, La Clair J, Müller R (2018)
Mar. Drugs 16 (9)DOI: 10.3390/md16090314
Future Directions of Marine Myxobacterial Natural Product Discovery Inferred from Metagenomics
Garcia R, La Clair J, Müller R (2018)
Mar. Drugs 16 (9)DOI: 10.3390/md16090303
Simulacricoccus ruber gen. nov., sp. nov., a microaerotolerant, non-fruiting, myxospore-forming soil myxobacterium and emended description of the family Myxococcaceae
Garcia R, Müller R (2018)
Int. J. Syst. Evol. Microbiol. 68 (10): 3101-3110DOI: 10.1099/ijsem.0.002936
Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria
Hoffmann T, Krug D, Bozkurt N, Duddela S, Jansen R, Garcia R, Gerth K, Steinmetz H, Müller R (2018)
Nat. Commun. 9 (1)DOI: 10.1038/s41467-018-03184-1
2017
Pyxipyrrolones: Structure elucidation and biosynthesis of cytotoxic myxobacterial metabolites
Kjaerulff L, Raju R, Panter F, Scheid U, Garcia R, Herrmann J, Müller R (2017)
Angew. Chem. Int. Ed. 56 (32): 9614-9618DOI: 10.1002/anie.201704790
Vitiosangium cumulatum gen. nov., sp. nov. and Vitiosangium subalbum sp. nov., soil myxobacteria, and emended descriptions of the genera Archangium and Angiococcus, and of the family Cystobacteraceae
Awal R, Garcia R, Gemperlein K, Wink J, Kunwar B, Parajuli N, Müller R (2017)
Int. J. Syst. Evol. Microbiol. 67 (5): 1422-1430DOI: 10.1099/ijsem.0.001829
Solving the puzzle of the one-carbon loss in ripostatin biosynthesis
Fu C, Auerbach D, Li Y, Scheid U, Luxenburger E, Garcia R, Irschik H, Müller R (2017)
Angew. Chem. Int. Ed. Engl. 56 (8): 2192-2197DOI: 10.1002/anie.201609950
2016
Racemicystis crocea gen. nov., sp. nov., a novel soil myxobacterium in Polyangiaceae
Awal R, Garcia R, Müller R (2016)
Int. J. Syst. Evol. Microbiol. (66)DOI: 10.1099/ijsem.0.001045
Aetherobacter fasciculatus gen. nov., sp. nov. and Aetherobacter rufus gen. nov., sp. nov., two novel myxobacteria with promising biotechnological applications
Garcia R, Stadler M, Gemperlein K, Müller R (2016)
Int. J. Syst. Evol. Microbiol. 66: 928-938DOI: 10.1099/ijsem.0.000813
2015
Synthetic pathway enzymes for the production of Argyrins
Müller R, Wenzel S, Garcia R (2015)
Patent (US9217169 B2)
Cystochromones, unusual chromone-containing polyketides from the myxobacterium Cystobacter sp. MCy9104
Nadmid S, Plaza A, Garcia R, Müller R (2015)
J. Nat. Prod. 78 (8): 2023-8DOI: 10.1021/acs.jnatprod.5b00343
Aggregicoccus edonensis gen. nov., sp. nov., an unusually aggregating myxobacterium isolated from a soil sample
Sood S, Awal R, Wink J, Mohr K, Rohde M, Stadler M, Kämpfer P, Glaeser S, Schumann P, Garcia R, Müller R (2015)
Int. J. Syst. Evol. Microbiol. 65 (Pt 3): 745-753DOI: 10.1099/ijs.0.061176-0
2014
Minicystis rosea gen. nov., sp. nov., a polyunsaturated fatty acid-rich and steroid-producing soil myxobacterium
Garcia R, Gemperlein K, Müller R (2014)
Int. J. Syst. Evol. Microbiol. 64 (Pt 11): 3733-3742DOI: 10.1099/ijs.0.068270-0
Hyalachelins A-C, unusual siderophores isolated from the terrestrial myxobacterium Hyalangium minutum
Nadmid S, Plaza A, Lauro G, Garcia R, Bifulco G, Müller R (2014)
Org. Lett. 16 (16): 4130-4133DOI: 10.1021/ol501826a
Cystomanamides: structure and biosynthetic pathway of a family of glycosylated lipopeptides from myxobacteria
Etzbach L, Plaza A, Garcia R, Baumann S, Müller R (2014)
Org. Lett. 16 (9): 2414-2417DOI: 10.1021/ol500779s
Angiolactone, a new Butyrolactone isolated from the terrestrial myxobacterium, Angiococcus sp.
Raju R, Garcia R, Müller R (2014)
J. Antibiot. epub ahead of printDOI: 10.1038/ja.2014.55
Polyunsaturated fatty acid biosynthesis in myxobacteria
Gemperlein K, Rachid S, Garcia R, Wenzel S, Müller R (2014)
Chem. Sci. 5 (5): 1733-1741DOI: 10.1039/C3SC53163E
2013
Jahnellamides, a-keto-ß-methionine-containing peptides from the terrestrial myxobacterium Jahnella sp.: structure and biosynthesis
Plaza A, Viehrig K, Garcia R, Müller R (2013)
Org. Lett. 15 (22): 5882-5885DOI: 10.1021/ol402967y
Microsclerodermins from terrestrial myxobacteria: An intriguing biosynthesis likely connected to a sponge symbiont
Hoffmann T, Müller S, Nadmid S, Garcia R, Müller R (2013)
J. Am. Chem. Soc. 45 (135): 16904-16911DOI: 10.1021/ja4054509
2012
Aetheramides A and B, potent HIV-inhibitory depsipeptides from a myxobacterium of the new genus 'Aetherobacter'
Plaza A, Garcia R, Bifulco G, Martinez J, Hüttel S, Sasse F, Meyerhans A, Stadler M, Müller R (2012)
Org. Lett. 14 (11): 2854-2857DOI: 10.1021/ol3011002
Sandaracinus amylolyticus gen. nov., sp. nov., a starch-degrading soil myxobacterium, and description of Sandaracinaceae fam. nov
Mohr K, Garcia R, Gerth K, Irschik H, Müller R (2012)
Int. J. Syst. Evol. Microbiol. 62 (Pt 5): 1191-1198DOI: 10.1099/ijs.0.033696-0
2011
Bendigoles D-F, bioactive sterols from the marine sponge-derived Actinomadura sp. SBMs009
Simmons L, Kaufmann K, Garcia R, Schwär G, Huch V, Müller R (2011)
Bioorganic & Medicinal Chemistry 19 (22): 6570-6575DOI: 10.1016/j.bmc.2011.05.044
A highly conjugated dihydroxylated C28 steroid from a myxobacterium
Gawas D, Garcia R, Huch V, Müller R (2011)
Journal of natural products 74 (5): 1281-1283DOI: 10.1021/np100682c
Fatty acid-related phylogeny of myxobacteria as an approach to discover polyunsaturated omega-3/6 fatty acids
Garcia R, Pistorius D, Stadler M, Müller R (2011)
J. Bacteriol. 193 (8): 1930-1942DOI: 10.1128/JB.01091-10
2010
Production of omega-3 fatty acids by myxobacteria International Patent
Stadler M, Roemer E, Müller R, Garcia R, Pistorius D, Brachmann A (2010)
Patent (International Patent WO 2010/063451 A2)
Expanded phylogeny of myxobacteria and evidence for cultivation of the 'unculturables'
Garcia R, Gerth K, Stadler M, Dogma Jr. I, Müller R (2010)
Mol. Phylogenet. Evol. 57 (2): 878-887DOI: 10.1016/j.ympev.2010.08.028
2009
Phaselicystis flava gen. nov., sp. nov., an arachidonic acid-containing soil myxobacterium, and the description of Phaselicystidaceae fam. nov
Garcia R, Reichenbach H, Ring M, Müller R (2009)
Int. J. Syst. Evol. Microbiol. 59 (6): 1524-1530DOI: 10.1099/ijs.0.003814-0
2008
Efficient mining of myxobacterial metabolite profiles enabled by liquid chromatography-electrospray ionization-time-of-flight mass spectrometry and compound-based principal component analysis
Krug D, Zurek G, Schneider B, Garcia R, Müller R (2008)
Anal. Chim. Acta 624 (1): 97-106DOI: 10.1016/j.aca.2008.06.036