EN | DE
 info(at)helmholtz-hips.de
 Directions to Google
EN | DE
Researchers in HIPS Laboratory

Search

Searched for "drug". Displaying results 771 to 780 of 784.

Synthesis and Biological Evaluation of Novel 2-Substituted ­Analogues of (–)-Pentenomycin I

Publication
Zisopoulou S, Bousis S, Haupenthal J, Herrmann J, Müller R, Hirsch A, Komiotis D, Gallos J, Stathakis C (2020)
Synlett, 31, 05, 475-481, 10.1055/s-0039-1690772

Advanced mutasynthesis studies on the natural α-pyrone antibiotic myxopyronin from Myxococcus fulvus

Publication
Sahner J, Sucipto H, Wenzel S, Groh M, Hartmann R, Müller R (2015)
ChemBioChem, 16, 946-953, 10.1002/cbic.201402666, 25757034

Towards the sustainable discovery and development of new antibiotics

Publication
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo P, Glaser P, Aigle B, Bode H, Moreira R, Li Y, Luzhetskyy A, Medema M, Pernodet J, Stadler M, Tormo J, Genilloud O, Truman A, Weissman K, Takano E, Sabatini S, Stegmann E, Brötz-Oesterhelt H, Wohlleben W, Seemann M, Empting M, Hirsch A, Loretz B, Lehr C, Titz A, Herrmann J, Jaeger T, Alt S, Hesterkamp T, Winterhalter M, Schiefer A, Pfarr K, Hoerauf A, Graz H, Graz M, Lindvall M, Ramurthy S, Karlén A, van Dongen M, Petkovic H, Keller A, Peyrane F, Donadio S, Fraisse L, Piddock L, Gilbert I, Moser H, Müller R (2021)
Nature reviews. Chemistry, 5, 10, 726-749, 10.1038/s41570-021-00313-1, 34426795

Innovative zinc-binding inhibitors of Legionella pneumophila ProA reduce collagen and flagellin degradation, TLR5 evasion, and human lung tissue inflammation

Publication
Scheithauer L, Ornago C, Selmar J, Schütz C, Bianchi G, Kiefer A, Haupenthal J, Dellmann A, Huynh D, Zhang R, Blankenfeldt W, Hirsch A, Steinert M (2025)
European journal of medicinal chemistry, 296, 10.1016/j.ejmech.2025.117832, 40479898

Unlocking the Antiviral Arsenal: Structure-Guided Optimization of Small-Molecule Inhibitors against RSV and hCoV-229E

Publication
Karhan C, Sake S, Gunesch A, Grethe C, Hellwinkel B, Köhler N, Kiefer A, Hapko U, Kany A, Pietschmann T, Hirsch A (2025)
European journal of medicinal chemistry, 10.1016/j.ejmech.2025.117282

Dual inhibitors of Pseudomonas aeruginosa virulence factors LecA and LasB

Publication
Metelkina O, Konstantinovic J, Klein A, Shafiei R, Fares M, Alhayek A, Yahiaoui S, Elgaher W, Haupenthal J, Titz* A, Hirsch* A (2024)
Chem. Sci., 15, 10.1039/D4SC02703E

Dynamic Combinatorial Chemistry Unveils Nsp10 Inhibitors with Antiviral Potential Against SARS-CoV-2

Publication
Jumde R, Jézéquel G, Saramago M, Frank N, Adam S, Cunha M, Bader C, Gunesch A, Köhler N, Johannsen S, Bousis S, Pietschmann T, Matos R, Müller R, Arraiano C, Hirsch A (2024)
Chem. - Eur. J., 10.1002/chem.202403390, 39676060

Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters

Publication
Kiefer A, Bousis S, Hamed M, Diamanti E, Haupenthal J, Hirsch A (2022)
J. Med. Chem., 10.1021/acs.jmedchem.1c02114

A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d -galactose pentaacetate

Publication
Zahorska E, Kuhaudomlarp S, Minervini S, Yousaf S, Lepsik M, Kinsinger T, Hirsch A, Imberty A, Titz A (2020)
Chem. Commun., 56, 62, 8822-8825, 10.1039/d0cc03490h

Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model

Publication
Kiefer A, Schütz C, Englisch C, Kolling D, Speicher S, Kany A, Shafiei R, Wadood N, Aljohmani A, Wirschem N, Jumde R, Klein A, Sikandar A, Park Y, Krasteva-Christ G, Yildiz D, Abdelsamie A, Rox K, Köhnke J, Müller R, Bischoff M, Haupenthal J, Hirsch A (2025)
Adv. Sci., 10.1002/advs.202411807, 39973061