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Researchers in HIPS Laboratory

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Searched for "drug". Displaying results 761 to 770 of 774.

Expanding the Myxochelin Natural Product Family by Nicotinic Acid Containing Congeners

Publication
Frank N, Széles M, Akone S, Rasheed S, Hüttel S, Frewert S, Hamed M, Herrmann J, Schuler S, Hirsch A, Müller R (2021)
Molecules, 26, 16, 10.3390/molecules26164929

Genome Mining Guided Identification of the Metallophore Delftichelin A from Delftia deserti

Publication
Kruijff M, Hiller L, Birkelbach J, Decker T, Götze S, Kochems R, Müller R, Hirsch A, Beemelmanns C (2026)
Journal of natural products, 10.1021/acs.jnatprod.6c00213

Advanced mutasynthesis studies on the natural α-pyrone antibiotic myxopyronin from Myxococcus fulvus

Publication
Sahner J, Sucipto H, Wenzel S, Groh M, Hartmann R, Müller R (2015)
ChemBioChem, 16, 946-953, 10.1002/cbic.201402666, 25757034

Towards the sustainable discovery and development of new antibiotics

Publication
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo P, Glaser P, Aigle B, Bode H, Moreira R, Li Y, Luzhetskyy A, Medema M, Pernodet J, Stadler M, Tormo J, Genilloud O, Truman A, Weissman K, Takano E, Sabatini S, Stegmann E, Brötz-Oesterhelt H, Wohlleben W, Seemann M, Empting M, Hirsch A, Loretz B, Lehr C, Titz A, Herrmann J, Jaeger T, Alt S, Hesterkamp T, Winterhalter M, Schiefer A, Pfarr K, Hoerauf A, Graz H, Graz M, Lindvall M, Ramurthy S, Karlén A, van Dongen M, Petkovic H, Keller A, Peyrane F, Donadio S, Fraisse L, Piddock L, Gilbert I, Moser H, Müller R (2021)
Nature reviews. Chemistry, 5, 10, 726-749, 10.1038/s41570-021-00313-1, 34426795

Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters

Publication
Kiefer A, Bousis S, Hamed M, Diamanti E, Haupenthal J, Hirsch A (2022)
J. Med. Chem., 10.1021/acs.jmedchem.1c02114

Dual inhibitors of Pseudomonas aeruginosa virulence factors LecA and LasB

Publication
Metelkina O, Konstantinovic J, Klein A, Shafiei R, Fares M, Alhayek A, Yahiaoui S, Elgaher W, Haupenthal J, Titz* A, Hirsch* A (2024)
Chem. Sci., 15, 10.1039/D4SC02703E

Dynamic Combinatorial Chemistry Unveils Nsp10 Inhibitors with Antiviral Potential Against SARS-CoV-2

Publication
Jumde R, Jézéquel G, Saramago M, Frank N, Adam S, Cunha M, Bader C, Gunesch A, Köhler N, Johannsen S, Bousis S, Pietschmann T, Matos R, Müller R, Arraiano C, Hirsch A (2024)
Chem. - Eur. J., 10.1002/chem.202403390, 39676060

A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d -galactose pentaacetate

Publication
Zahorska E, Kuhaudomlarp S, Minervini S, Yousaf S, Lepsik M, Kinsinger T, Hirsch A, Imberty A, Titz A (2020)
Chem. Commun., 56, 62, 8822-8825, 10.1039/d0cc03490h

Unlocking the Antiviral Arsenal: Structure-Guided Optimization of Small-Molecule Inhibitors against RSV and hCoV-229E

Publication
Karhan C, Sake S, Gunesch A, Grethe C, Hellwinkel B, Köhler N, Kiefer A, Hapko U, Kany A, Pietschmann T, Hirsch A (2025)
European journal of medicinal chemistry, 10.1016/j.ejmech.2025.117282

Innovative zinc-binding inhibitors of Legionella pneumophila ProA reduce collagen and flagellin degradation, TLR5 evasion, and human lung tissue inflammation

Publication
Scheithauer L, Ornago C, Selmar J, Schütz C, Bianchi G, Kiefer A, Haupenthal J, Dellmann A, Huynh D, Zhang R, Blankenfeldt W, Hirsch A, Steinert M (2025)
European journal of medicinal chemistry, 296, 10.1016/j.ejmech.2025.117832, 40479898