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Current methods and applications in the study of 1-Deoxy-D-xylulose 5-phosphate synthase (DXPS)
Publication
Gawriljuk V,
Chen S,
Kramer L,
Smith N,
Diamanti E,
Hirsch A,
Freel Meyers C,
Groves M
(2026)
Methods in enzymology, 736, 61-94, 10.1016/bs.mie.2026.08.001, 42805709
Methods in enzymology, 736, 61-94, 10.1016/bs.mie.2026.08.001, 42805709
Hit-to-Lead Optimization of Energy-Coupling Factor (ECF) Transporter Inhibitors as Novel Antibiotic
Publication
Exapicheidou I,
Tsarenko A,
Zeller L,
Ibrahim H,
Baumann C,
Shams A,
Hoffmann P,
Li Y,
Kany A,
Hermann J,
Slotboom D,
Müller R,
Volkamer A,
Hamed M,
Diamanti E,
Hirsch A
(2026)
Journal of medicinal chemistry, 69, 12, 14069-14084, 10.1021/acs.jmedchem.5c02721, 42249838
Journal of medicinal chemistry, 69, 12, 14069-14084, 10.1021/acs.jmedchem.5c02721, 42249838
An investigation of phosphinamides as a functional group for medicinal chemistry
Publication
Meurillon V,
Blanchart P,
Ullah V,
Chan D,
Perry M
(2026)
Med Chem Res, 35, 1, 118-134, 10.1007/s00044-025-03498-y
Med Chem Res, 35, 1, 118-134, 10.1007/s00044-025-03498-y
Cytochrome P450-Mediated Metabolism of Antimycobacterial Nα-Aroyl-N-aryl-phenylalanine Amides
Publication
Doering J,
Meerz E,
Seidel R,
Lang M,
Kany A,
Auriola S,
Juvonen R,
Raunio H,
Goddard R,
Zimmerman M,
Dartois V,
Hirsch A,
Dick T,
Richter A
(2026)
ACS Infect. Dis., 12, 6, 10.1021/acsinfecdis.6c00100, 42227659
ACS Infect. Dis., 12, 6, 10.1021/acsinfecdis.6c00100, 42227659
Identification of Natural-Product Inhibitors of the 2 C -Methyl- d -erythritol 4-Phosphate Pathway
Publication
Diamanti E,
Alhayek A,
Lacour A,
Shahrour M,
Willocx D,
Illarionov B,
Fischer M,
Stadler M,
Reiling N,
Herrmann J,
Müller R,
Hirsch A
(2026)
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.6c00054
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.6c00054
Design and Optimization of Simplified Inhibitors Targeting E. coli and K. pneumoniae IspE
Publication
Walsh D,
Hamid R,
Giele T,
Rottmann M,
Hirsch A,
Hamed M,
Reiling N
(2026)
RSC Med. Chem., 17, 3, 10.1039/D5MD00874C
RSC Med. Chem., 17, 3, 10.1039/D5MD00874C
From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds
Publication
Keddis P,
My Tu T,
Scherer H,
Kany A,
Hafez D,
Darwish S,
Abadi A,
Hirsch A,
Engel M,
Hamed M,
Horng J,
Abdel-Halim M
(2025)
Eur. J. Med. Chem., 287, 10.1016/j.ejmech.2025.117348, 39947051
Eur. J. Med. Chem., 287, 10.1016/j.ejmech.2025.117348, 39947051
Apo structure of Mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate synthase DXPS: Dynamics and implications for inhibitor design
Publication
Gawriljuk V,
Alhayek A,
Hirsch A,
Groves M
(2025)
Biochemical and Biophysical Research Communications, 747, 10.1016/j.bbrc.2024.151246
Biochemical and Biophysical Research Communications, 747, 10.1016/j.bbrc.2024.151246
The isoprenoid-precursor dependence of Plasmodium spp
Publication
van der Meer J,
Hirsch A
(2012)
Natural product reports, 29, 7, 721-8, 10.1039/c2np20013a, 22555616
Natural product reports, 29, 7, 721-8, 10.1039/c2np20013a, 22555616
Metal-ion-induced shape switching: Stereoselective formation of a dinuclear Hg(II) double helicate from a hydrazonobis(acylhydrazone) ligand
Publication
Schaeffer G,
Harrowfield J,
Lehn J,
Hirsch A
(2012)
, 10.1016/J.POLY.2012.04.013
, 10.1016/J.POLY.2012.04.013