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Hit-to-Lead Optimization of Energy-Coupling Factor (ECF) Transporter Inhibitors as Novel Antibiotic
Publication
Exapicheidou I,
Tsarenko A,
Zeller L,
Ibrahim H,
Baumann C,
Shams A,
Hoffmann P,
Li Y,
Kany A,
Hermann J,
Slotboom D,
Müller R,
Volkamer A,
Hamed M,
Diamanti E,
Hirsch A
(2026)
Journal of medicinal chemistry, 69, 12, 14069-14084, 10.1021/acs.jmedchem.5c02721, 42249838
Journal of medicinal chemistry, 69, 12, 14069-14084, 10.1021/acs.jmedchem.5c02721, 42249838
An investigation of phosphinamides as a functional group for medicinal chemistry
Publication
Meurillon V,
Blanchart P,
Ullah V,
Chan D,
Perry M
(2026)
Med Chem Res, 35, 1, 118-134, 10.1007/s00044-025-03498-y
Med Chem Res, 35, 1, 118-134, 10.1007/s00044-025-03498-y
Cytochrome P450-Mediated Metabolism of Antimycobacterial Nα-Aroyl-N-aryl-phenylalanine Amides
Publication
Doering J,
Meerz E,
Seidel R,
Lang M,
Kany A,
Auriola S,
Juvonen R,
Raunio H,
Goddard R,
Zimmerman M,
Dartois V,
Hirsch A,
Dick T,
Richter A
(2026)
ACS Infect. Dis., 12, 6, 10.1021/acsinfecdis.6c00100, 42227659
ACS Infect. Dis., 12, 6, 10.1021/acsinfecdis.6c00100, 42227659
Identification of Natural-Product Inhibitors of the 2 C -Methyl- d -erythritol 4-Phosphate Pathway
Publication
Diamanti E,
Alhayek A,
Lacour A,
Shahrour M,
Willocx D,
Illarionov B,
Fischer M,
Stadler M,
Reiling N,
Herrmann J,
Müller R,
Hirsch A
(2026)
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.6c00054
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.6c00054
Design and Optimization of Simplified Inhibitors Targeting E. coli and K. pneumoniae IspE
Publication
Walsh D,
Hamid R,
Giele T,
Rottmann M,
Hirsch A,
Hamed M,
Reiling N
(2026)
RSC Med. Chem., 17, 3, 10.1039/D5MD00874C
RSC Med. Chem., 17, 3, 10.1039/D5MD00874C
Exploring the Role of Pseudomonas aeruginosa Elastase in Lung Epithelial Barrier Dysfunction: Advancing toward Antivirulence Therapies
Publication
Shafiei R,
Alhayek A,
Hiller L,
Latta L,
Neu T,
Aljohmani A,
Abdollahibiroun S,
Schönborn E,
Yildiz D,
Schneider-Daum N,
Lehr C,
Haupenthal J,
Hirsch A
(2026)
ACS Infect. Dis., 10.1021/acsinfecdis.5c00915, 41960628
ACS Infect. Dis., 10.1021/acsinfecdis.5c00915, 41960628
From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds
Publication
Keddis P,
My Tu T,
Scherer H,
Kany A,
Hafez D,
Darwish S,
Abadi A,
Hirsch A,
Engel M,
Hamed M,
Horng J,
Abdel-Halim M
(2025)
Eur. J. Med. Chem., 287, 10.1016/j.ejmech.2025.117348, 39947051
Eur. J. Med. Chem., 287, 10.1016/j.ejmech.2025.117348, 39947051
'Triazole bridge': disulfide-bond replacement by ruthenium-catalyzed formation of 1,5-disubstituted 1,2,3-triazoles
Publication
Empting M,
Avrutina O,
Meusinger R,
Fabritz S,
Reinwarth M,
Biesalski M,
Voigt S,
Buntkowsky G,
Kolmar H
(2011)
Angewandte Chemie (International ed. in English), 50, 22, 5207-11, 10.1002/anie.201008142, 21544910
Angewandte Chemie (International ed. in English), 50, 22, 5207-11, 10.1002/anie.201008142, 21544910
Towards click bioconjugations on cube-octameric silsesquioxane scaffolds
Publication
Fabritz S,
Heyl D,
Bagutski V,
Empting M,
Rikowski E,
Frauendorf H,
Balog I,
Fessner W,
Schneider J,
Avrutina O,
Kolmar H
(2010)
Org. Biomol. Chem., 8, 9, 2212-8, 10.1039/b923393h, 20401398
Org. Biomol. Chem., 8, 9, 2212-8, 10.1039/b923393h, 20401398
Application of copper(I) catalyzed azide-alkyne 3+2 cycloaddition to the synthesis of template-assembled multivalent peptide conjugates
Publication
Avrutina O,
Empting M,
Fabritz S,
Daneschdar M,
Frauendorf H,
Diederichsen U,
Kolmar H
(2009)
Org. Biomol. Chem., 7, 20, 4177-85, 10.1039/b908261a, 19795056
Org. Biomol. Chem., 7, 20, 4177-85, 10.1039/b908261a, 19795056