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Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor
Publication
Drost M,
Diamanti E,
Fuhrmann K,
Goes A,
Shams A,
Haupenthal J,
Koch M,
Hirsch A,
Fuhrmann G
(2022)
Pharmaceutics, 14, 1, 10.3390/pharmaceutics14010004
Pharmaceutics, 14, 1, 10.3390/pharmaceutics14010004
Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors
Publication
Wimmer S,
Hoff K,
Martin B,
Grewer M,
Denni L,
Lascorz Massanet R,
Raimondi M,
Bülbül E,
Melesina J,
Hotop S,
Haupenthal J,
Rohde H,
Heisig P,
Hirsch A,
Brönstrup M,
Sippl W,
Holl R
(2022)
Bioorganic chemistry, 131, 10.1016/j.bioorg.2022.106331, 36587505
Bioorganic chemistry, 131, 10.1016/j.bioorg.2022.106331, 36587505
New Ketene Dithioacetals Generated from 2-Nitroperchlorobutadiene and Investigation of Their Antibacterial, Antifungal, Anticonvulsant and Antidepressant Activities
Publication
Aydinli S,
Bulut E,
Deniz N,
Sayil C,
Komarovska-Porokhnyavets O,
Lubenets V,
Zvarych V,
Stasevych M,
Nesterkina M,
Kravchenko I
(2022)
Chemistry & Biodiversity, 19, 7, 10.1002/cbdv.202100931, 35674435
Chemistry & Biodiversity, 19, 7, 10.1002/cbdv.202100931, 35674435
Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases
Publication
Alhayek A,
Abdelsamie A,
Schönauer E,
Camberlein V,
Hutterer E,
Posselt G,
Serwanja J,
Blöchl C,
Huber C,
Haupenthal J,
Brandstetter H,
Wessler S,
Hirsch A
(2022)
Journal of medicinal chemistry, 65, 19, 12933-12955, 10.1021/acs.jmedchem.2c00785, 36154055
Journal of medicinal chemistry, 65, 19, 12933-12955, 10.1021/acs.jmedchem.2c00785, 36154055
Targeting IspD for Anti-infective and Herbicide Development: Exploring Its Role, Mechanism, and Structural Insights
Publication
Willocx D,
Diamanti E,
Hirsch A
(2025)
Journal of medicinal chemistry, 10.1021/acs.jmedchem.4c01146, 39749898
Journal of medicinal chemistry, 10.1021/acs.jmedchem.4c01146, 39749898
Lignin-derived guaiacols as platform chemicals for the modular synthesis of 1,2,3,4-tetrahydroquinolines and benzomorpholines
Publication
Castillo-Garcia A,
Haupenthal J,
Hirsch A,
Barta K
(2025)
RSC sustainability, 3, 9, 4039-4048, 10.1039/d5su00151j, 40686926
RSC sustainability, 3, 9, 4039-4048, 10.1039/d5su00151j, 40686926
Role of Electrostatics in Metal–Organic Junctions on Surfaces: para -Hexaphenyl-dicarbonitrile on Au(111)
Publication
Pérez Paz A,
Mowbray D,
Gottardi S,
Solianyk L,
Li J,
Monjas L,
Hirsch A,
Stöhr M,
Moreno-López J
(2025)
Chem. Mater., 37, 18, 7115-7124, 10.1021/acs.chemmater.5c01172
Chem. Mater., 37, 18, 7115-7124, 10.1021/acs.chemmater.5c01172
Targeting isoprenoid-precursor biosynthesis in Klebsiella pneumoniae: Design, synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) inhibitors
Publication
Eisa S,
Lacour A,
Johannsen S,
Hamid R,
Raj P,
Heinz D,
Hamed M,
Diamanti E,
Hirsch A
(2025)
Bioorg. Chem., 164, 10.1016/j.bioorg.2025.108877, 40845551
Bioorg. Chem., 164, 10.1016/j.bioorg.2025.108877, 40845551
Design, Synthesis, and Biological Evaluation of Mono- and Diamino-Substituted Squaramide Derivatives as Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthase
Publication
Palme P,
Grover S,
Abdelaziz R,
Mann L,
Kany A,
Ouologuem L,
Bartel K,
Sonnenkalb L,
Reiling N,
Hirsch A,
Schnappinger D,
Rubinstein J,
Imming P,
Richter A
(2025)
J. Med. Chem., 68, 23, 25274-25289, 10.1021/acs.jmedchem.5c02284, 41277442
J. Med. Chem., 68, 23, 25274-25289, 10.1021/acs.jmedchem.5c02284, 41277442
1-Deoxy-D-xylulose 5-phosphate synthase: structural perspectives on an essential enzyme in isoprenoid biosynthesis
Publication
Gawriljuk V,
Oerlemans R,
Reddem E,
Gierse R,
Hirsch A,
Groves M
(2025)
J. Struct. Biol., 217, 3, 10.1016/j.jsb.2025.108236, 40784416
J. Struct. Biol., 217, 3, 10.1016/j.jsb.2025.108236, 40784416