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Researchers in HIPS Laboratory

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Searched for "drug". Displaying results 701 to 710 of 748.

Bioconjugates to specifically render inhibitors water-soluble

Publication
Hirsch A, Diederich F, Antonietti M, Börner H (2009)
Soft Matter, 6, 1, 88-91, 10.1039/B915928B

Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis

Publication
Hirsch A, Alphey M, Lauw S, Seet M, Barandun L, Eisenreich W, Rohdich F, Hunter W, Bacher A, Diederich F (2008)
Organic & biomolecular chemistry, 6, 15, 2719-30, 10.1039/b804375b, 18633530

Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis

Publication
Crane C, Hirsch A, Alphey M, Sgraja T, Lauw S, Illarionova V, Rohdich F, Eisenreich W, Hunter W, Bacher A, Diederich F (2008)
ChemMedChem, 3, 1, 91-101, 10.1002/cmdc.200700208, 18033714

Phosphate recognition in structural biology

Publication
Hirsch A, Fischer F, Diederich F (2007)
Angewandte Chemie (International ed. in English), 46, 3, 338-52, 10.1002/anie.200603420, 17154432

Nonphosphate inhibitors of IspE protein, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy

Publication
Hirsch A, Lauw S, Gersbach P, Schweizer W, Rohdich F, Eisenreich W, Bacher A, Diederich F (2007)
ChemMedChem, 2, 6, 806-10, 10.1002/cmdc.200700014, 17361977

Double conjugate addition of dithiols to propargylic carbonyl systems to generate protected 1,3-dicarbonyl compounds

Publication
Sneddon H, van den Heuvel A, Hirsch A, Booth R, Shaw D, Gaunt M, Ley S (2006)
The Journal of organic chemistry, 71, 7, 2715-25, 10.1021/jo052514s, 16555825

pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA

Publication
Liu Y, Ashmawy S, Latta L, Weiss A, Kiefer A, Nasr S, Loretz B, Hirsch A, Lee S, Lehr C (2023)
Biomacromolecules, 24, 8, 3742-3754, 10.1021/acs.biomac.3c00424, 37523746

Cancer cells have an Achilles heel: Saarbrücken pharmacy contributes to new therapy strategy

News
Alexandra K. Kiemer, Simon Both, Martin Empting

Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies

Publication
Maurer C, Fruth M, Empting M, Avrutina O, Hossmann J, Nadmid S, Gorges J, Herrmann J, Kazmaier U, Dersch P, Muller R, Hartmann R (2016)
Future medicinal chemistry, 8, 9, 931-47, 10.4155/fmc-2016-0033, 27253623

N -Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases

Publication
Konstantinovic J, Yahiaoui S, Alhayek A, Haupenthal J, Schönauer E, Andreas A, Kany A, Müller R, Koehnke J, Berger F, Bischoff M, Hartmann R, Brandstetter H, Hirsch A (2020)
J. Med. Chem., 63, 15, 8359-8368, 10.1021/acs.jmedchem.0c00584