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A natural-product switch for a dynamic protein interface
Publication
Scheepstra M,
Nieto L,
Hirsch A,
Fuchs S,
Leysen S,
Lam C,
het Panhuis L,
van Boeckel C,
Wienk H,
Boelens R,
Ottmann C,
Milroy L,
Brunsveld L
(2014)
Angewandte Chemie (International ed. in English), 53, 25, 6443-8, 10.1002/anie.201403773, 24821627
Angewandte Chemie (International ed. in English), 53, 25, 6443-8, 10.1002/anie.201403773, 24821627
Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker
Publication
Abdelsamie A,
Bey E,
Hanke N,
Empting M,
Hartmann R,
Frotscher M
(2014)
European journal of medicinal chemistry, 82, 394-406, 10.1016/j.ejmech.2014.05.074, 24929290
European journal of medicinal chemistry, 82, 394-406, 10.1016/j.ejmech.2014.05.074, 24929290
Theoretical and structural analysis of long C-C bonds in the adducts of polycyanoethylene and anthracene derivatives and their connection to the reversibility of Diels-Alder reactions
Publication
Hirsch A,
Reutenauer P,
Le Moignan M,
Ulrich S,
Boul P,
Harrowfield J,
Jarowski P,
Lehn J
(2014)
Chemistry (Weinheim an der Bergstrasse, Germany), 20, 4, 1073-80, 10.1002/chem.201303276, 24339005
Chemistry (Weinheim an der Bergstrasse, Germany), 20, 4, 1073-80, 10.1002/chem.201303276, 24339005
PHIP-label: parahydrogen-induced polarization in propargylglycine-containing synthetic oligopeptides
Publication
Körner M,
Sauer G,
Heil A,
Nasu D,
Empting M,
Tietze D,
Voigt S,
Weidler H,
Gutmann T,
Avrutina O,
Kolmar H,
Ratajczyk T,
Buntkowsky G
(2013)
Chemical communications (Cambridge, England), 49, 71, 7839-41, 10.1039/c3cc43978j, 23887355
Chemical communications (Cambridge, England), 49, 71, 7839-41, 10.1039/c3cc43978j, 23887355
Total synthesis, stereochemical elucidation and biological evaluation of Ac 2 SGL; a 1,3-methyl branched sulfoglycolipid from Mycobacterium tuberculosis
Publication
Geerdink D,
Horst B,
Lepore M,
Mori L,
Puzo G,
Hirsch A,
Gilleron M,
Libero G,
Minnaard A
(2013)
, 10.1039/C2SC21620E
, 10.1039/C2SC21620E
Imidazole- and Benzimidazole-Based Inhibitors of the Kinase IspE: Targeting the Substrate-Binding Site and the Triphosphate-Binding Loop of the ATP Site
Publication
Mombelli P,
Le Chapelain C,
Munzinger N,
Joliat E,
Illarionov B,
Schweizer W,
Hirsch A,
Fischer M,
Bacher A,
Diederich F
(2013)
, 10.1002/EJOC.201201467
, 10.1002/EJOC.201201467
The isoprenoid-precursor dependence of Plasmodium spp
Publication
van der Meer J,
Hirsch A
(2012)
Natural product reports, 29, 7, 721-8, 10.1039/c2np20013a, 22555616
Natural product reports, 29, 7, 721-8, 10.1039/c2np20013a, 22555616
Metal-ion-induced shape switching: Stereoselective formation of a dinuclear Hg(II) double helicate from a hydrazonobis(acylhydrazone) ligand
Publication
Schaeffer G,
Harrowfield J,
Lehn J,
Hirsch A
(2012)
, 10.1016/J.POLY.2012.04.013
, 10.1016/J.POLY.2012.04.013
Exploring the Ribose Sub-Pocket of the Substrate-Binding Site in Escherichia coli IspE: Structure-Based Design, Synthesis, and Biological Evaluation of Cytosines and Cytosine Analogues
Publication
Schütz A,
Osawa S,
Mathis J,
Hirsch A,
Bernet B,
Illarionov B,
Fischer M,
Bacher A,
Diederich F
(2012)
, 10.1002/EJOC.201200296
, 10.1002/EJOC.201200296
From pico to nano: biofunctionalization of cube-octameric silsesquioxanes by peptides and miniproteins
Publication
Fabritz S,
Hörner S,
Könning D,
Empting M,
Reinwarth M,
Dietz C,
Glotzbach B,
Frauendorf H,
Kolmar H,
Avrutina O
(2012)
Org. Biomol. Chem., 10, 31, 6287-93, 10.1039/c2ob25728a, 22733169
Org. Biomol. Chem., 10, 31, 6287-93, 10.1039/c2ob25728a, 22733169