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Identification of inhibitors targeting the energy-coupling factor (ECF) transporters
Publication
Diamanti E,
Souza P,
Setyawati I,
Bousis S,
Monjas L,
Swier L,
Shams A,
Tsarenko A,
Stanek W,
Jäger M,
Marrink S,
slotboom d,
Hirsch A
(2024)
Communications Biology, 7, 1, 10.1038/s42003-024-05770-0, 38195913
Communications Biology, 7, 1, 10.1038/s42003-024-05770-0, 38195913
IspE kinase as an anti-infective target: Role of a hydrophobic pocket in inhibitor binding
Publication
Hamid R,
Walsh D,
Diamanti E,
Aguilar D,
Lacour A,
Hamed M,
Hirsch A
(2024)
Structure (London, England : 1993), 32, 12, 2390-2398, 10.1016/j.str.2024.10.009, 39510075
Structure (London, England : 1993), 32, 12, 2390-2398, 10.1016/j.str.2024.10.009, 39510075
High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum
Publication
Johannsen S,
Gierse R,
Krüger A,
Edwards R,
Nanna V,
Fontana A,
Di Zhu,
Masini T,
Carvalho L,
Poizat M,
Kieftenbelt B,
Hodge D,
Alvarez S,
Bunt D,
Lacour A,
Shams A,
Meissner K,
Souza E,
Dröge M,
van Vliet B,
Hartog J,
Hutter M,
Held J,
Odom John A,
Wrenger C,
Hirsch* A
(2024)
ACS Infect. Dis., 10.1021/acsinfecdis.3c00670, 38367280
ACS Infect. Dis., 10.1021/acsinfecdis.3c00670, 38367280
Targeting the Plasmodium falciparum IspE Enzyme
Publication
Diamanti E,
Steinbach A,
Carvalho L,
Ropponen H,
Lacour A,
Hamid R,
Eisa S,
Bravo P,
Bousis S,
Illarionov B,
Fischer M,
Hamed M,
Bach N,
Rottmann M,
Held J,
Witschel M,
Sieber S,
Hirsch A
(2024)
ACS omega, 9, 44, 44465-44473, 10.1021/acsomega.4c06038, 39524657
ACS omega, 9, 44, 44465-44473, 10.1021/acsomega.4c06038, 39524657
Targeting IspD for Anti-infective and Herbicide Development: Exploring Its Role, Mechanism, and Structural Insights
Publication
Willocx D,
Diamanti E,
Hirsch A
(2025)
Journal of medicinal chemistry, 10.1021/acs.jmedchem.4c01146, 39749898
Journal of medicinal chemistry, 10.1021/acs.jmedchem.4c01146, 39749898
Lignin-derived guaiacols as platform chemicals for the modular synthesis of 1,2,3,4-tetrahydroquinolines and benzomorpholines
Publication
Castillo-Garcia A,
Haupenthal J,
Hirsch A,
Barta K
(2025)
RSC sustainability, 3, 9, 4039-4048, 10.1039/d5su00151j, 40686926
RSC sustainability, 3, 9, 4039-4048, 10.1039/d5su00151j, 40686926
Role of Electrostatics in Metal–Organic Junctions on Surfaces: para -Hexaphenyl-dicarbonitrile on Au(111)
Publication
Pérez Paz A,
Mowbray D,
Gottardi S,
Solianyk L,
Li J,
Monjas L,
Hirsch A,
Stöhr M,
Moreno-López J
(2025)
Chem. Mater., 37, 18, 7115-7124, 10.1021/acs.chemmater.5c01172
Chem. Mater., 37, 18, 7115-7124, 10.1021/acs.chemmater.5c01172
Targeting isoprenoid-precursor biosynthesis in Klebsiella pneumoniae: Design, synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) inhibitors
Publication
Eisa S,
Lacour A,
Johannsen S,
Hamid R,
Raj P,
Heinz D,
Hamed M,
Diamanti E,
Hirsch A
(2025)
Bioorg. Chem., 164, 10.1016/j.bioorg.2025.108877, 40845551
Bioorg. Chem., 164, 10.1016/j.bioorg.2025.108877, 40845551
1-Deoxy-D-xylulose 5-phosphate synthase: structural perspectives on an essential enzyme in isoprenoid biosynthesis
Publication
Gawriljuk V,
Oerlemans R,
Reddem E,
Gierse R,
Hirsch A,
Groves M
(2025)
J. Struct. Biol., 217, 3, 10.1016/j.jsb.2025.108236, 40784416
J. Struct. Biol., 217, 3, 10.1016/j.jsb.2025.108236, 40784416
Tobramycin crosslinking improves the colloidal stability of arginine chitosan biodynamers for safe and efficient siRNA delivery
Publication
Liu Y,
Biesel A,
Kamal M,
Latta L,
Loretz B,
Hirsch A,
Lee S,
Lehr C
(2025)
Int. J. Biol. Macromol., 311, Pt 1, 10.1016/j.ijbiomac.2025.143420, 40274164
Int. J. Biol. Macromol., 311, Pt 1, 10.1016/j.ijbiomac.2025.143420, 40274164