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Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents
Publication
Kaya C,
Hirsch A
(2022)
Chimia, 76, 5, 10.2533/chimia.2022.402
Chimia, 76, 5, 10.2533/chimia.2022.402
Screening of Natural Products and Small Molecules Uncovers Novel Coronavirus 1a/1b Frameshifting Inhibitors with Antiviral Properties
Publication
Kibe A,
Elgaher W,
Rand U,
Zimmer M,
Kany A,
Hermann J,
Müller R,
Cicin-Sain L,
Hirsch A,
Caliskan N
(2022)
SSRN Journal, 10.2139/ssrn.4157446
SSRN Journal, 10.2139/ssrn.4157446
Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages
Publication
Sake S,
Kosch C,
Blockus S,
Haid S,
Gunesch A,
Zhang X,
Friesland M,
Trummer S,
Grethe C,
Kühnel A,
Rückert J,
Duprex W,
Huang J,
Rameix-Welti M,
Empting M,
Fischer N,
Hirsch A,
Schulz T,
Pietschmann T
(2022)
Antimicrobial agents and chemotherapy, 10.1128/aac.01032-22, 36346232
Antimicrobial agents and chemotherapy, 10.1128/aac.01032-22, 36346232
Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry
Publication
Bagnolini G,
Balboni B,
Schipani F,
Gioia D,
Veronesi M,
Franco F,
Kaya C,
Jumde R,
Ortega J,
Girotto S,
Hirsch A,
Roberti M,
Cavalli A
(2022)
ACS Med. Chem. Lett., 13, 8, 1262-1269, 10.1021/acsmedchemlett.2c00063, 35978685
ACS Med. Chem. Lett., 13, 8, 1262-1269, 10.1021/acsmedchemlett.2c00063, 35978685
Rheological Properties of Hyaluronic Acid Diluted Solutions as Components of Cosmetics
Publication
Svetlana Saitarly,
Yuriy Pushkarev,
Nesterkina M,
Serhat Öztürk,
Iryna Kravchenko
(2021)
Biointerface Res Appl Chem, 12, 2, 1907-1915, 10.33263/BRIAC122.19071915
Biointerface Res Appl Chem, 12, 2, 1907-1915, 10.33263/BRIAC122.19071915
Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE
Publication
Braun-Cornejo M,
Ornago C,
Sonawane V,
Haupenthal J,
Kany A,
Diamanti E,
Jézéquel G,
Reiling N,
Blankenfeldt W,
Maas P,
Hirsch A
(2024)
ACS omega, 10.1021/acsomega.4c05537
ACS omega, 10.1021/acsomega.4c05537
AI is a viable alternative to high throughput screening: a 318-target study
Publication
Wallach I,
Hirsch,
Anna K. H. et al.
(2024)
Sci. Rep., 14, 1, 10.1038/s41598-024-54655-z, 38565852
Sci. Rep., 14, 1, 10.1038/s41598-024-54655-z, 38565852
Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes
Publication
Geißler A,
Junca H,
Kany A,
Daumann L,
Hirsch A,
Pieper D,
Sieber S
(2024)
Chem. Sci., 15, 30, 11946-11955, 10.1039/D4SC01940G, 39092115
Chem. Sci., 15, 30, 11946-11955, 10.1039/D4SC01940G, 39092115
Spray drying of a zinc complexing agent for inhalation therapy of pulmonary fibrosis
Publication
Stella J,
Abdelaal M,
Kamal M,
Shehu K,
Alhayek A,
Haupenthal J,
Hirsch A,
Schneider M
(2024)
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 202, 10.1016/j.ejps.2024.106891, 39233259
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 202, 10.1016/j.ejps.2024.106891, 39233259
Targeting Plasmodium falciparum IspD in the Methyl-d-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity
Publication
Willocx D,
Bizzarri L,
Alhayek A,
Kannan D,
Bravo P,
Illarionov B,
Rox K,
Lohse J,
Fischer M,
Kany A,
Hahne H,
Rottmann M,
Witschel M,
Odom John A,
Hamed M,
Diamanti E,
Hirsch A
(2024)
Journal of medicinal chemistry, 67, 19, 17070-17086, 10.1021/acs.jmedchem.4c00212, 39303294
Journal of medicinal chemistry, 67, 19, 17070-17086, 10.1021/acs.jmedchem.4c00212, 39303294