EN | DE
 info(at)helmholtz-hips.de +49681988063001
 Directions to Google
EN | DE
Researchers in HIPS Laboratory

Search

Searched for "drug". Displaying results 671 to 680 of 748.

Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis

Publication
Camberlein V, Fléau C, Sierocki P, Li L, Gealageas R, Bosc D, Guillaume V, Warenghem S, Leroux F, Rosell M, Cheng K, Medve L, Prigent M, Decanter M, Piveteau C, Biela A, Eveque M, Dumont J, Mpakali A, Giastas P, Herledan A, Couturier C, Haupenthal J, Lesire L, Hirsch A, Deprez B, Stratikos E, Bouvier M, Deprez-Poulain R (2022)
Angew. Chemie, 134, 39, 10.1002/ange.202203560

Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa

Publication
Kaya C, Walter I, Alhayek A, Shafiei R, Jézéquel G, Andreas A, Konstantinovic J, Schönauer E, Sikandar A, Haupenthal J, Müller R, Brandstetter H, Hartmann R, Hirsch A (2022)
ACS Infect. Dis., 10.1021/acsinfecdis.1c00628, 35451824

PHARMACOLOGICAL AND PHYSICO-CHEMICAL PROPERTIES OF COMPOSITIONS BASED ON BIOSURFACTANTS AND N-CONTAINING HETEROCYCLIC DERIVATIVES OF 1,4-NAPHTHOQUINONE

Publication
Polish N, Nesterkina M, Karkhut A, Marintsova N, Zhurakhivska L, Volianiuk K, Pokynbroda T, Kravchenko I, Karpenko E (2022)
J microb biotech food sci, 12, 3, 10.55251/jmbfs.5956

Structural analysis of 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding

Publication
Hamid R, Adam S, Lacour A, Gomez L, Hirsch A (2022)
bioRxiv, 10.1101/2022.07.04.498669

Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism

Publication
Chen F, Elgaher W, Winterhoff M, Büssow K, Waqas F, Graner E, Pires-Afonso Y, Casares Perez L, La Vega L, Sahini N, Czichon L, Zobl W, Zillinger T, Shehata M, Pleschka S, Bähre H, Falk C, Michelucci A, Schuchardt S, Blankenfeldt W, Hirsch A, Pessler F (2022)
Nature metabolism, 4, 5, 534-546, 10.1038/s42255-022-00577-x, 35655026

Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents

Publication
Kaya C, Hirsch A (2022)
Chimia, 76, 5, 10.2533/chimia.2022.402

Screening of Natural Products and Small Molecules Uncovers Novel Coronavirus 1a/1b Frameshifting Inhibitors with Antiviral Properties

Publication
Kibe A, Elgaher W, Rand U, Zimmer M, Kany A, Hermann J, Müller R, Cicin-Sain L, Hirsch A, Caliskan N (2022)
SSRN Journal, 10.2139/ssrn.4157446

Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages

Publication
Sake S, Kosch C, Blockus S, Haid S, Gunesch A, Zhang X, Friesland M, Trummer S, Grethe C, Kühnel A, Rückert J, Duprex W, Huang J, Rameix-Welti M, Empting M, Fischer N, Hirsch A, Schulz T, Pietschmann T (2022)
Antimicrobial agents and chemotherapy, 10.1128/aac.01032-22, 36346232

Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity

Publication
Mielniczuk S, Hoff K, Baselious F, Li Y, Haupenthal J, Kany A, Riedner M, Rohde H, Rox K, Hirsch A, Krimm I, Sippl W, Holl R (2024)
Journal of medicinal chemistry, 67, 19, 17363-17391, 10.1021/acs.jmedchem.4c01262, 39303295

Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity

Publication
Al-Saad O, Gabr M, Darwish S, Rullo M, Pisani L, Miniero D, Liuzzi G, Kany A, Hirsch A, Abadi A, Engel M, Catto M, Abdel-Halim M (2024)
European journal of medicinal chemistry, 10.1016/j.ejmech.2024.116266