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Integral Solvent-Induced Protein Precipitation for Target-Engagement Studies in Plasmodium falciparum
Publication
Bravo P,
Bizzarri L,
Steinbrunn D,
Lohse J,
Hirsch A,
Mäser P,
Rottmann M,
Hahne H
(2024)
ACS Infect. Dis., 10, 12, 4073-4086, 10.1021/acsinfecdis.4c00418, 39631773
ACS Infect. Dis., 10, 12, 4073-4086, 10.1021/acsinfecdis.4c00418, 39631773
Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT
Publication
Exapicheidou I,
Shams A,
Ibrahim H,
Tsarenko A,
Backenköhler M,
Hamed M,
Diamanti E,
Volkamer A,
slotboom d,
Hirsch A
(2024)
Chem. Commun., 60, 7, 870-873, 10.1039/D3CC04738E, 38164786
Chem. Commun., 60, 7, 870-873, 10.1039/D3CC04738E, 38164786
Identification of inhibitors targeting the energy-coupling factor (ECF) transporters
Publication
Diamanti E,
Souza P,
Setyawati I,
Bousis S,
Monjas L,
Swier L,
Shams A,
Tsarenko A,
Stanek W,
Jäger M,
Marrink S,
slotboom d,
Hirsch A
(2024)
Communications Biology, 7, 1, 10.1038/s42003-024-05770-0, 38195913
Communications Biology, 7, 1, 10.1038/s42003-024-05770-0, 38195913
IspE kinase as an anti-infective target: Role of a hydrophobic pocket in inhibitor binding
Publication
Hamid R,
Walsh D,
Diamanti E,
Aguilar D,
Lacour A,
Hamed M,
Hirsch A
(2024)
Structure (London, England : 1993), 32, 12, 2390-2398, 10.1016/j.str.2024.10.009, 39510075
Structure (London, England : 1993), 32, 12, 2390-2398, 10.1016/j.str.2024.10.009, 39510075
High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum
Publication
Johannsen S,
Gierse R,
Krüger A,
Edwards R,
Nanna V,
Fontana A,
Di Zhu,
Masini T,
Carvalho L,
Poizat M,
Kieftenbelt B,
Hodge D,
Alvarez S,
Bunt D,
Lacour A,
Shams A,
Meissner K,
Souza E,
Dröge M,
van Vliet B,
Hartog J,
Hutter M,
Held J,
Odom John A,
Wrenger C,
Hirsch* A
(2024)
ACS Infect. Dis., 10.1021/acsinfecdis.3c00670, 38367280
ACS Infect. Dis., 10.1021/acsinfecdis.3c00670, 38367280
Targeting the Plasmodium falciparum IspE Enzyme
Publication
Diamanti E,
Steinbach A,
Carvalho L,
Ropponen H,
Lacour A,
Hamid R,
Eisa S,
Bravo P,
Bousis S,
Illarionov B,
Fischer M,
Hamed M,
Bach N,
Rottmann M,
Held J,
Witschel M,
Sieber S,
Hirsch A
(2024)
ACS omega, 9, 44, 44465-44473, 10.1021/acsomega.4c06038, 39524657
ACS omega, 9, 44, 44465-44473, 10.1021/acsomega.4c06038, 39524657
Role of Electrostatics in Metal–Organic Junctions on Surfaces: para -Hexaphenyl-dicarbonitrile on Au(111)
Publication
Pérez Paz A,
Mowbray D,
Gottardi S,
Solianyk L,
Li J,
Monjas L,
Hirsch A,
Stöhr M,
Moreno-López J
(2025)
Chem. Mater., 37, 18, 7115-7124, 10.1021/acs.chemmater.5c01172
Chem. Mater., 37, 18, 7115-7124, 10.1021/acs.chemmater.5c01172
Targeting isoprenoid-precursor biosynthesis in Klebsiella pneumoniae: Design, synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) inhibitors
Publication
Eisa S,
Lacour A,
Johannsen S,
Hamid R,
Raj P,
Heinz D,
Hamed M,
Diamanti E,
Hirsch A
(2025)
Bioorg. Chem., 164, 10.1016/j.bioorg.2025.108877, 40845551
Bioorg. Chem., 164, 10.1016/j.bioorg.2025.108877, 40845551
1-Deoxy-D-xylulose 5-phosphate synthase: structural perspectives on an essential enzyme in isoprenoid biosynthesis
Publication
Gawriljuk V,
Oerlemans R,
Reddem E,
Gierse R,
Hirsch A,
Groves M
(2025)
J. Struct. Biol., 217, 3, 10.1016/j.jsb.2025.108236, 40784416
J. Struct. Biol., 217, 3, 10.1016/j.jsb.2025.108236, 40784416
Tobramycin crosslinking improves the colloidal stability of arginine chitosan biodynamers for safe and efficient siRNA delivery
Publication
Liu Y,
Biesel A,
Kamal M,
Latta L,
Loretz B,
Hirsch A,
Lee S,
Lehr C
(2025)
Int. J. Biol. Macromol., 311, Pt 1, 10.1016/j.ijbiomac.2025.143420, 40274164
Int. J. Biol. Macromol., 311, Pt 1, 10.1016/j.ijbiomac.2025.143420, 40274164