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Researchers in HIPS Laboratory

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Searched for "drug". Displaying results 661 to 670 of 748.

Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster

Publication
Nesterkina M, Bilokon S, Alieksieieva T, Kravchenko I, Hirsch A (2023)
Toxicol. Rep., 10, 10.1016/j.toxrep.2023.02.009

Selective Activation of TRPC6 Ion Channel by Metallated Type-B Polyprenylated Polycyclic Acylphloroglucinols

Publication
Peslalz P, Kraus F, Izzo F, Bleisch A, El Hamdaoui Y, Schulz I, Kany A, Hirsch A, Friedland K, Plietker B (2023)
Manuscript, 10.26434/chemrxiv-2023-6w94r

Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle

Publication
Hamed M, Abdelsamie A, Rox K, Schütz C, Kany A, Röhrig T, Schmelz S, Blankenfeldt W, Arce-Rodriguez A, Borrero-de Acuña J, Jahn D, Rademacher J, Ringshausen F, Cramer N, Tümmler B, Hirsch A, Hartmann R, Empting M (2023)
Adv. Sci., Online, 10.1002/advs.202204443

Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation

Publication
Chan A, Ho T, Irfan R, Hamid R, Rudge E, Iqbal A, Turner A, Hirsch A., Leeper F (2023)
Bioorganic chemistry, 138, 10.1016/j.bioorg.2023.106602

1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding

Publication
Hamid R, Adam S, Lacour A, Monjas L, Köhnke J, Hirsch A (2023)
The Journal of biological chemistry, 10.1016/j.jbc.2023.105152, 37567475

Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE

Publication
Braun-Cornejo M, Ornago C, Sonawane V, Haupenthal J, Kany A, Diamanti E, Jézéquel G, Reiling N, Blankenfeldt W, Maas P, Hirsch A (2024)
ACS omega, 10.1021/acsomega.4c05537

AI is a viable alternative to high throughput screening: a 318-target study

Publication
Wallach I, Hirsch, Anna K. H. et al. (2024)
Sci. Rep., 14, 1, 10.1038/s41598-024-54655-z, 38565852

Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes

Publication
Geißler A, Junca H, Kany A, Daumann L, Hirsch A, Pieper D, Sieber S (2024)
Chem. Sci., 15, 30, 11946-11955, 10.1039/D4SC01940G, 39092115

Spray drying of a zinc complexing agent for inhalation therapy of pulmonary fibrosis

Publication
Stella J, Abdelaal M, Kamal M, Shehu K, Alhayek A, Haupenthal J, Hirsch A, Schneider M (2024)
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 202, 10.1016/j.ejps.2024.106891, 39233259

Targeting Plasmodium falciparum IspD in the Methyl-d-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity

Publication
Willocx D, Bizzarri L, Alhayek A, Kannan D, Bravo P, Illarionov B, Rox K, Lohse J, Fischer M, Kany A, Hahne H, Rottmann M, Witschel M, Odom John A, Hamed M, Diamanti E, Hirsch A (2024)
Journal of medicinal chemistry, 67, 19, 17070-17086, 10.1021/acs.jmedchem.4c00212, 39303294