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Apo structure of Mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate synthase DXPS: Dynamics and implications for inhibitor design
Publication
Gawriljuk V,
Alhayek A,
Hirsch A,
Groves M
(2025)
Biochemical and Biophysical Research Communications, 747, 10.1016/j.bbrc.2024.151246
Biochemical and Biophysical Research Communications, 747, 10.1016/j.bbrc.2024.151246
Direct monitoring of intracellular polymer degradation via BODIPY dynamic dequenching
Publication
Bassil J,
Kamal M,
Gabelmann A,
Christoulaki A,
Koch M,
Hamed M,
Loretz B,
Gallei M,
Buhler E,
Lehr C,
Hirsch A,
Lee S
(2025)
Mater. Des., 256, 10.1016/j.matdes.2025.114240
Mater. Des., 256, 10.1016/j.matdes.2025.114240
Targeting IspD for Anti-infective and Herbicide Development: Exploring Its Role, Mechanism, and Structural Insights
Publication
Willocx D,
Diamanti E,
Hirsch A
(2025)
Journal of medicinal chemistry, 10.1021/acs.jmedchem.4c01146, 39749898
Journal of medicinal chemistry, 10.1021/acs.jmedchem.4c01146, 39749898
Lignin-derived guaiacols as platform chemicals for the modular synthesis of 1,2,3,4-tetrahydroquinolines and benzomorpholines
Publication
Castillo-Garcia A,
Haupenthal J,
Hirsch A,
Barta K
(2025)
RSC sustainability, 3, 9, 4039-4048, 10.1039/d5su00151j, 40686926
RSC sustainability, 3, 9, 4039-4048, 10.1039/d5su00151j, 40686926
Role of Electrostatics in Metal–Organic Junctions on Surfaces: para -Hexaphenyl-dicarbonitrile on Au(111)
Publication
Pérez Paz A,
Mowbray D,
Gottardi S,
Solianyk L,
Li J,
Monjas L,
Hirsch A,
Stöhr M,
Moreno-López J
(2025)
Chem. Mater., 37, 18, 7115-7124, 10.1021/acs.chemmater.5c01172
Chem. Mater., 37, 18, 7115-7124, 10.1021/acs.chemmater.5c01172
Targeting isoprenoid-precursor biosynthesis in Klebsiella pneumoniae: Design, synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) inhibitors
Publication
Eisa S,
Lacour A,
Johannsen S,
Hamid R,
Raj P,
Heinz D,
Hamed M,
Diamanti E,
Hirsch A
(2025)
Bioorg. Chem., 164, 10.1016/j.bioorg.2025.108877, 40845551
Bioorg. Chem., 164, 10.1016/j.bioorg.2025.108877, 40845551
Design, Synthesis, and Biological Evaluation of Mono- and Diamino-Substituted Squaramide Derivatives as Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthase
Publication
Palme P,
Grover S,
Abdelaziz R,
Mann L,
Kany A,
Ouologuem L,
Bartel K,
Sonnenkalb L,
Reiling N,
Hirsch A,
Schnappinger D,
Rubinstein J,
Imming P,
Richter A
(2025)
J. Med. Chem., 68, 23, 25274-25289, 10.1021/acs.jmedchem.5c02284, 41277442
J. Med. Chem., 68, 23, 25274-25289, 10.1021/acs.jmedchem.5c02284, 41277442
Fine-tuning Nanocarriers Specifically toward Cargo: A Competitive Study on Solubilizing Related Photosensitizers for Photodynamic Therapy
Publication
Wieczorek S,
Remmler D,
Masini T,
Kochovski Z,
Hirsch A,
Börner H
(2017)
Bioconjugate chemistry, 28, 3, 760-767, 10.1021/acs.bioconjchem.6b00549, 28002941
Bioconjugate chemistry, 28, 3, 760-767, 10.1021/acs.bioconjchem.6b00549, 28002941
Molecular insight into specific 14-3-3 modulators: Inhibitors and stabilisers of protein-protein interactions of 14-3-3
Publication
Hartman A,
Hirsch A
(2017)
European journal of medicinal chemistry, 136, 10.1016/j.ejmech.2017.04.058, 28549334
European journal of medicinal chemistry, 136, 10.1016/j.ejmech.2017.04.058, 28549334
Synthesis and Pharmacological Properties of Novel Esters Based on Monoterpenoids and Glycine
Publication
Nesterkina M,
Kravchenko I
(2017)
Pharmaceuticals (Basel, Switzerland), 10, 2, 10.3390/ph10020047, 28524111
Pharmaceuticals (Basel, Switzerland), 10, 2, 10.3390/ph10020047, 28524111