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1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding
Publication
Hamid R,
Adam S,
Lacour A,
Monjas L,
Köhnke J,
Hirsch A
(2023)
The Journal of biological chemistry, 10.1016/j.jbc.2023.105152, 37567475
The Journal of biological chemistry, 10.1016/j.jbc.2023.105152, 37567475
Identification of DksA as a novel pro-inflammatory mediator of Pseudomonas aeruginosa under conditions mimicking chronic cystic fibrosis lung infection
Publication
Wauters M,
Bollé L,
Meester G,
van den Bossche S,
Grassi L,
van Haver D,
Dufour S,
Devos S,
Impens F,
van Braeckel E,
Hirsch A,
Whiteley M,
Saelens X,
Crabbé A
(2026)
Virulence, 17, 1, 10.1080/21505594.2026.2670050, 42117785
Virulence, 17, 1, 10.1080/21505594.2026.2670050, 42117785
Multiparameter Optimization of Pseudomonas aeruginosa Elastase Inhibitors for Systemic Administration
Publication
Abdelsamie A,
Konstantinovic J,
Kany A,
Schütz C,
Kolling D,
Speicher S,
Klein A,
Shafiei R,
Bouté M,
Mundry K,
Park Y,
Loretz B,
Müller R,
Sallenave J,
Lehr C,
Koehnke J,
Rox K,
Haupenthal J,
Hirsch A
(2026)
J. Med. Chem., 69, 4, 4160-4186, 10.1021/acs.jmedchem.5c02788, 41642952
J. Med. Chem., 69, 4, 4160-4186, 10.1021/acs.jmedchem.5c02788, 41642952
An investigation of phosphinamides as a functional group for medicinal chemistry
Publication
Meurillon V,
Blanchart P,
Ullah V,
Chan D,
Perry M
(2026)
Med Chem Res, 35, 1, 118-134, 10.1007/s00044-025-03498-y
Med Chem Res, 35, 1, 118-134, 10.1007/s00044-025-03498-y
Hit-to-Lead Optimization of Energy-Coupling Factor (ECF) Transporter Inhibitors as Novel Antibiotic
Publication
Exapicheidou I,
Tsarenko A,
Zeller L,
Ibrahim H,
Baumann C,
Shams A,
Hoffmann P,
Li Y,
Kany A,
Hermann J,
Slotboom D,
Müller R,
Volkamer A,
Hamed M,
Diamanti E,
Hirsch A
(2026)
J. Med. Chem., 10.1021/acs.jmedchem.5c02721, 42249838
J. Med. Chem., 10.1021/acs.jmedchem.5c02721, 42249838
Cytochrome P450-Mediated Metabolism of Antimycobacterial Nα-Aroyl-N-aryl-phenylalanine Amides
Publication
Doering J,
Meerz E,
Seidel R,
Lang M,
Kany A,
Auriola S,
Juvonen R,
Raunio H,
Goddard R,
Zimmerman M,
Dartois V,
Hirsch A,
Dick T,
Richter A
(2026)
ACS Infect. Dis., 10.1021/acsinfecdis.6c00100, 42227659
ACS Infect. Dis., 10.1021/acsinfecdis.6c00100, 42227659
Identification of Natural-Product Inhibitors of the 2 C -Methyl- d -erythritol 4-Phosphate Pathway
Publication
Diamanti E,
Alhayek A,
Lacour A,
Shahrour M,
Willocx D,
Illarionov B,
Fischer M,
Stadler M,
Reiling N,
Herrmann J,
Müller R,
Hirsch A
(2026)
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.6c00054
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.6c00054
Design and Optimization of Simplified Inhibitors Targeting E. coli and K. pneumoniae IspE
Publication
Walsh D,
Hamid R,
Giele T,
Rottmann M,
Hirsch A,
Hamed M,
Reiling N
(2026)
RSC Med. Chem., 10.1039/D5MD00874C
RSC Med. Chem., 10.1039/D5MD00874C
Exploring the Role of Pseudomonas aeruginosa Elastase in Lung Epithelial Barrier Dysfunction: Advancing toward Antivirulence Therapies
Publication
Shafiei R,
Alhayek A,
Hiller L,
Latta L,
Neu T,
Aljohmani A,
Abdollahibiroun S,
Schönborn E,
Yildiz D,
Schneider-Daum N,
Lehr C,
Haupenthal J,
Hirsch A
(2026)
ACS Infect. Dis., 10.1021/acsinfecdis.5c00915, 41960628
ACS Infect. Dis., 10.1021/acsinfecdis.5c00915, 41960628
From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds
Publication
Keddis P,
My Tu T,
Scherer H,
Kany A,
Hafez D,
Darwish S,
Abadi A,
Hirsch A,
Engel M,
Hamed M,
Horng J,
Abdel-Halim M
(2025)
Eur. J. Med. Chem., 287, 10.1016/j.ejmech.2025.117348, 39947051
Eur. J. Med. Chem., 287, 10.1016/j.ejmech.2025.117348, 39947051