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Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa
Publication
Kaya C,
Walter I,
Alhayek A,
Shafiei R,
Jézéquel G,
Andreas A,
Konstantinovic J,
Schönauer E,
Sikandar A,
Haupenthal J,
Müller R,
Brandstetter H,
Hartmann R,
Hirsch A
(2022)
ACS Infect. Dis., 10.1021/acsinfecdis.1c00628, 35451824
ACS Infect. Dis., 10.1021/acsinfecdis.1c00628, 35451824
PHARMACOLOGICAL AND PHYSICO-CHEMICAL PROPERTIES OF COMPOSITIONS BASED ON BIOSURFACTANTS AND N-CONTAINING HETEROCYCLIC DERIVATIVES OF 1,4-NAPHTHOQUINONE
Publication
Polish N,
Nesterkina M,
Karkhut A,
Marintsova N,
Zhurakhivska L,
Volianiuk K,
Pokynbroda T,
Kravchenko I,
Karpenko E
(2022)
J microb biotech food sci, 12, 3, 10.55251/jmbfs.5956
J microb biotech food sci, 12, 3, 10.55251/jmbfs.5956
Structural analysis of 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding
Publication
Hamid R,
Adam S,
Lacour A,
Gomez L,
Hirsch A
(2022)
bioRxiv, 10.1101/2022.07.04.498669
bioRxiv, 10.1101/2022.07.04.498669
Behavioral and electrophysiological responses of the male medfly, Ceratitis capitata, to thymol and carvacrol ethers
Publication
Tabanca N,
Cloonan K,
Nesterkina M,
Gill M,
Montgomery W,
Kravchenko I,
Kendra P
(2024)
Pest management science, 10.1002/ps.8324, 39096116
Pest management science, 10.1002/ps.8324, 39096116
Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes
Publication
Chan A,
Ho T,
Fathoni I,
Hamid R,
Hirsch A,
Saliba K,
Leeper F
(2024)
RSC Med. Chem., 15, 5, 1773-1781, 10.1039/D4MD00083H, 38784473
RSC Med. Chem., 15, 5, 1773-1781, 10.1039/D4MD00083H, 38784473
Studying Target-Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry
Publication
Bizzarri L,
Steinbrunn D,
Quennesson T,
Lacour A,
Bianchino G,
Bravo P,
Chaignon P,
Lohse J,
Mäser P,
Seemann M,
van Calenbergh S,
Hirsch A,
Hahne H
(2024)
ACS Infect. Dis., 10, 12, 4087-4102, 10.1021/acsinfecdis.4c00417, 39566904
ACS Infect. Dis., 10, 12, 4087-4102, 10.1021/acsinfecdis.4c00417, 39566904
Synthesis and Structure of a Coordination Polymer of Ni(II) with 2-(4-Bromophenoxy)acetohydrazide
Publication
Martsynko ?,
Nesterkina M,
Finik ?,
Tsymbaliuk K,
Dyakonenko V,
Shishkina S,
Kravchenko I
(2024)
Molbank, 2024, 2, 10.3390/M1819
Molbank, 2024, 2, 10.3390/M1819
Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy-coupling factor transporters (ECFTs)
Publication
Haupenthal J,
Rafehi M,
Kany A,
Lespine A,
Stefan K,
Hirsch* A,
Stefan* S
(2024)
Arch. Pharm., 10.1002/ardp.202400267, 38896404
Arch. Pharm., 10.1002/ardp.202400267, 38896404
Not Every Hit-Identification Technique Works on 1-Deoxy-d-Xylulose 5-Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign
Publication
Johannsen S,
Gierse R,
Olshanova A,
Smerznak E,
Laggner C,
Eschweiler L,
Adeli Z,
Hamid R,
Alhayek A,
Reiling N,
Haupenthal J,
Hirsch A
(2023)
ChemMedChem, 10.1002/cmdc.202200590, 36896721
ChemMedChem, 10.1002/cmdc.202200590, 36896721
Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors
Publication
Ropponen H,
Diamanti E,
Johannsen S,
Illarionov B,
Hamid R,
Jaki M,
Sass P,
Fischer M,
Haupenthal J,
Hirsch A
(2023)
ChemMedChem, 10.1002/cmdc.202300346, 37718320
ChemMedChem, 10.1002/cmdc.202300346, 37718320