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NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner
Publication
Waqas F,
Shehata M,
Elgaher W,
Lacour A,
Kurmasheva N,
Begnini F,
Kiib A,
Dahlmann J,
Chen C,
Pavlou A,
Poulsen T,
Merkert S,
Martin U,
Olmer R,
Olagnier D,
Hirsch A,
Pleschka S,
Pessler F
(2023)
PLOS Pathogens, 19, 7, 10.1371/journal.ppat.1011506, 37459366
PLOS Pathogens, 19, 7, 10.1371/journal.ppat.1011506, 37459366
Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate
Publication
Gawriljuk V,
Oerlemans R,
Gierse R,
Jotwani R,
Hirsch A,
Groves M
(2023)
Crystals, 13, 5, 10.3390/cryst13050737
Crystals, 13, 5, 10.3390/cryst13050737
The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB
Publication
Camberlein V,
Jézéquel G,
Haupenthal J,
Hirsch A
(2022)
Antibiotics, 11, 8, 10.3390/antibiotics11081060
Antibiotics, 11, 8, 10.3390/antibiotics11081060
The Alkylquinolone Repertoire of Pseudomonas aeruginosa is Linked to Structural Flexibility of the FabH-like 2-Heptyl-3-hydroxy-4(1H)-quinolone (PQS) Biosynthesis Enzyme PqsBC
Publication
Witzgall F,
Depke T,
Hoffmann M,
Empting M,
Brönstrup M,
Müller R,
Blankenfeldt W
(2018)
Chembiochem : a European journal of chemical biology, 19, 14, 1531-1544, 10.1002/cbic.201800153, 29722462
Chembiochem : a European journal of chemical biology, 19, 14, 1531-1544, 10.1002/cbic.201800153, 29722462
Exploration of ligand binding modes towards the identification of compounds targeting HuR: a combined STD-NMR and Molecular Modelling approach
Publication
Vasile F,
Della Volpe S,
Ambrosio F,
Costa G,
Unver M,
Zucal C,
Rossi D,
Martino E,
Provenzani A,
Hirsch A,
Alcaro S,
Potenza D,
Collina S
(2018)
Sci. Rep., 8, 1, 10.1038/s41598-018-32084-z
Sci. Rep., 8, 1, 10.1038/s41598-018-32084-z
Lipid-DNAs as Solubilizers of m THPC
Publication
Liu Y,
de Vries J,
Liu Q,
Hartman A,
Wieland G,
Wieczorek S,
Börner H,
Wiehe A,
Buhler E,
Stuart M,
Browne W,
Herrmann A,
Hirsch A
(2018)
Chem. Eur. J., 24, 4, 798-802, 10.1002/chem.201705206
Chem. Eur. J., 24, 4, 798-802, 10.1002/chem.201705206
Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor
Publication
Kany A,
Sikandar A,
Yahiaoui S,
Haupenthal J,
Walter I,
Empting M,
Köhnke J,
Hartmann R
(2018)
ACS chemical biology, 13, 9, 2449-2455, 10.1021/acschembio.8b00257, 30088919
ACS chemical biology, 13, 9, 2449-2455, 10.1021/acschembio.8b00257, 30088919
Glucansucrase (mutant) enzymes from Lactobacillus reuteri 180 efficiently transglucosylate Stevia component rebaudioside A, resulting in a superior taste
Publication
Te Poele E,
Devlamynck T,
Jäger M,
Gerwig G,
van de Walle D,
Dewettinck K,
Hirsch A,
Kamerling J,
Soetaert W,
Dijkhuizen L
(2018)
Sci. Rep., 8, 1, 10.1038/s41598-018-19622-5, 29367749
Sci. Rep., 8, 1, 10.1038/s41598-018-19622-5, 29367749
The influence of monoterpenoids and phenol derivatives on Drosophila melanogaster viability
Publication
Nesterkina M,
Bilokon S,
Alieksieieva T,
Chubyk I,
Kravchenko I
(2018)
Journal of Asia-Pacific Entomology, 21, 3, 793-796, 10.1016/j.aspen.2018.06.004
Journal of Asia-Pacific Entomology, 21, 3, 793-796, 10.1016/j.aspen.2018.06.004
Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers
Publication
Schütz C,
Empting M
(2018)
Beilstein journal of organic chemistry, 14, 2627-2645, 10.3762/bjoc.14.241, 30410625
Beilstein journal of organic chemistry, 14, 2627-2645, 10.3762/bjoc.14.241, 30410625