EN | DE
 info(at)helmholtz-hips.de +49681988063001
 Directions to Google
EN | DE
Researchers in HIPS Laboratory

Search

Searched for "drug". Displaying results 651 to 660 of 748.

Selective Activation of TRPC6 Ion Channel by Metallated Type-B Polyprenylated Polycyclic Acylphloroglucinols

Publication
Peslalz P, Kraus F, Izzo F, Bleisch A, El Hamdaoui Y, Schulz I, Kany A, Hirsch A, Friedland K, Plietker B (2023)
Manuscript, 10.26434/chemrxiv-2023-6w94r

Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle

Publication
Hamed M, Abdelsamie A, Rox K, Schütz C, Kany A, Röhrig T, Schmelz S, Blankenfeldt W, Arce-Rodriguez A, Borrero-de Acuña J, Jahn D, Rademacher J, Ringshausen F, Cramer N, Tümmler B, Hirsch A, Hartmann R, Empting M (2023)
Adv. Sci., Online, 10.1002/advs.202204443

Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation

Publication
Chan A, Ho T, Irfan R, Hamid R, Rudge E, Iqbal A, Turner A, Hirsch A., Leeper F (2023)
Bioorganic chemistry, 138, 10.1016/j.bioorg.2023.106602

1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding

Publication
Hamid R, Adam S, Lacour A, Monjas L, Köhnke J, Hirsch A (2023)
The Journal of biological chemistry, 10.1016/j.jbc.2023.105152, 37567475

Identification of HuR–RNA Interfering Compounds by Dynamic Combinatorial Chemistry and Fluorescence Polarization

Publication
Della Volpe S, Listro R, Ambrosio F, Garbagnoli M, Linciano P, Rossi D, Costa G, Alcaro S, Vasile F, Hirsch A, Collina S (2023)
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.3c00303

NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner

Publication
Waqas F, Shehata M, Elgaher W, Lacour A, Kurmasheva N, Begnini F, Kiib A, Dahlmann J, Chen C, Pavlou A, Poulsen T, Merkert S, Martin U, Olmer R, Olagnier D, Hirsch A, Pleschka S, Pessler F (2023)
PLOS Pathogens, 19, 7, 10.1371/journal.ppat.1011506, 37459366

Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate

Publication
Gawriljuk V, Oerlemans R, Gierse R, Jotwani R, Hirsch A, Groves M (2023)
Crystals, 13, 5, 10.3390/cryst13050737

The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB

Publication
Camberlein V, Jézéquel G, Haupenthal J, Hirsch A (2022)
Antibiotics, 11, 8, 10.3390/antibiotics11081060

Design, Synthesis, Antimicrobial Activity, and Molecular Docking of Some New Diclofenac Derivatives

Publication
Tolba M, Hamed M, Sayed M, Kamal El-Dean A, Abdel-Mohsen S, Ibrahim O, Elgaher W, Hirsch A, Saddik A (2022)
Polycyclic Aromatic Compounds, 1-16, 10.1080/10406638.2022.2102661

N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases

Publication
Kaya C, Konstantinovic J, Kany A, Andreas A, Kramer J, Brunst S, Weizel L, Rotter M, Frank D, Yahiaoui S, Müller R, Hartmann R, Haupenthal J, Proschak E, Wichelhaus T, Hirsch A (2022)
Journal of medicinal chemistry, 65, 5, 3913-3922, 10.1021/acs.jmedchem.1c01755, 35188771